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JOURNAL ARTICLE
Shaun O'Leary, Janelle Heine, Jacelle Warren, Tanya Smyth, Emma Ballard, Gary Mitchell, William See, Panos Barlas, Gustavo C Machado, Michelle Cottrell, Tracy Comans, Nadine E Foster
INTRODUCTION: Management guidelines for low back pain (LBP) recommend exclusion of serious pathology, followed by simple analgesics, superficial heat therapy, early mobilisation and patient education. An audit in a large metropolitan hospital emergency department (ED) revealed high rates of non-recommended medication prescription for LBP (65% of patients prescribed opioids, 17% prescribed benzodiazepines), high inpatient admission rates (20% of ED LBP patients), delayed patient mobilisation (on average 6 hours) and inadequate patient education (48% of patients)...
March 12, 2024: BMJ Open
#22
JOURNAL ARTICLE
Atilla P Kiraly, Corbin A Cunningham, Ryan Najafi, Zaid Nabulsi, Jie Yang, Charles Lau, Joseph R Ledsam, Wenxing Ye, Diego Ardila, Scott M McKinney, Rory Pilgrim, Yun Liu, Hiroaki Saito, Yasuteru Shimamura, Mozziyar Etemadi, David Melnick, Sunny Jansen, Greg S Corrado, Lily Peng, Daniel Tse, Shravya Shetty, Shruthi Prabhakara, David P Naidich, Neeral Beladia, Krish Eswaran
"Just Accepted" papers have undergone full peer review and have been accepted for publication in Radiology: Artificial Intelligence . This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content. Purpose To evaluate the impact of an artificial intelligence (AI) assistant for lung cancer screening (LCS) on multinational clinical workflows...
March 13, 2024: Radiology. Artificial intelligence
#23
REVIEW
Alberto Nogales, Manuel Rodríguez-Aragón, Álvaro J García-Tejedor
Physiotherapy is a critical area of healthcare that involves the assessment and treatment of physical disabilities and injuries. The use of Artificial Intelligence (AI) in physiotherapy has gained significant attention due to its potential to enhance the accuracy and effectiveness of clinical decision-making and treatment outcomes. Nevertheless, it is still a rather innovative field of application of these techniques and there is a need to find what aspects are highly developed and what possible job niches can be exploited...
January 29, 2024: Computers in Biology and Medicine
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JOURNAL ARTICLE
Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus H Sneve, Paulien Moyaert, Oliver Geier, Joost P A Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike A Buck, Daniel C Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette Tippett, Erin E Cawston, Esin Ozturk-Isik, Jennifer Linn, Moritz Brandt, Betty M Tijms, Elsmarieke M van de Giessen, Majon Muller, Anders Fjell, Kristine Walhovd, Atle Bjørnerud, Lene Pålhaugen, Per Selnes, Patricia Clement, Eric Achten, Udunna Anazodo, Frederik Barkhof, Saima Hilal, Tormod Fladby, Klaus Eickel, Catherine Morgan, David L Thomas, Jan Petr, Matthias Günther, Henk J M M Mutsaerts
INTRODUCTION: Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer's disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and pose limitations in terms of cost and logistics. Arterial spin labelling (ASL) perfusion MRI has been recently adapted to map the BBB permeability non-invasively. The DEveloping BBB-ASL as a non-Invasive Early biomarker (DEBBIE) consortium aims to develop this modified ASL-MRI technique for patient-specific and robust BBB permeability assessments...
March 8, 2024: BMJ Open
#25
JOURNAL ARTICLE
Sebastien Bailly, Alison Foote, Monique Mendelson, Andry Rakotovao, Jean Christian Borel, Jean Louis Pepin, Renaud Tamisier, Helena Revil
INTRODUCTION: Obstructive sleep apnoea syndrome (OSAS) is a chronic multiorgan pathology that has a negative impact on quality of life. Continuous positive airway pressure (CPAP) is the first-line treatment for OSAS. However, CPAP termination rates remain very high, and adherence to therapy is a major issue. To date, studies targeting predictive factors of CPAP adherence by OSAS patients mainly include clinical data. The social, socioeconomic, psychological, and home environment aspects have been far less studied and largely underestimated...
March 5, 2024: BMJ Open
#26
JOURNAL ARTICLE
Charlotte Keenan, Muthafar Al-Haddawi, Jean-Guy Bienvenu, Alys Elizabeth Bradley, Paul Brown, Hepei Chen, Karyn Colman, Michael Elwell, Nicholas Gatto, Dawn Goodman, Binod Jacob, Lynda Lanning, LuAnn McKinney, Erin Muhlbradt, Rick Perry, Alessandro Piaia, Daniel Potenta, Karen S Regan, Benjamin Sefing, Michael Thibodeau, Erin Tibbs-Slone, Jochen Woicke, Craig M Zwickl
The Tumor Combination Guide was created at the request of the U. S. Food and Drug Administration (FDA) by a Working Group of biopharmaceutical experts from international societies of toxicologic pathology, the Food and Drug Administration (FDA), and members of the Standard for Exchange of Nonclinical Data (SEND) initiative, to assist pharmacology/toxicology reviewers and biostatisticians in statistical analysis of nonclinical tumor data. The guide will also be useful to study and peer review pathologists in interpreting the tumor data...
March 6, 2024: Toxicologic Pathology
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JOURNAL ARTICLE
Qixin Li, Jie Tan, He Xie, Xiaoyu Zhang, Qi Dai, Zhongwen Li, Lijing L Yan, Wei Chen
INTRODUCTION: Early eye screening and treatment can reduce the incidence of blindness by detecting and addressing eye diseases at an early stage. The Ophthalmologist Robot is an automated device that can simultaneously capture ocular surface and fundus images without the need for ophthalmologists, making it highly suitable for primary application. However, the accuracy of the device's screening capabilities requires further validation. This study aims to evaluate and compare the screening accuracies of ophthalmologists and deep learning models using images captured by the Ophthalmologist Robot, in order to identify a screening method that is both highly accurate and cost-effective...
March 1, 2024: BMJ Open
#28
JOURNAL ARTICLE
Wujianhong Liu, Aimaitiaji Kadier, Danjing Shen, Yanyan He, Shengrong Dong, Kun Zhu, Guang Xu, Binghui Zhao, Shiyu Mao, Changcheng Guo, Xudong Yao, Qin Wei, Dongyan Han, Bin Yang
INTRODUCTION: The classic way of diagnosing prostate cancer (PCa) is by conducting the 12-core systematic biopsy (SB). However, it has a low detection rate for clinically significant PCa (csPCa) and can lead to the detection of clinically insignificant PCa (cisPCa). Although MRI-transrectal ultrasound (MRI-TRUS) fusion targeted biopsy (TB) can effectively improve the detection rate of csPCa, it may still miss some cases. Therefore, we propose using a combination of TB and SB methods to enhance the detection rate of csPCa while minimising the detection rate of cisPCa...
March 1, 2024: BMJ Open
#29
JOURNAL ARTICLE
Tianlong Wang, Mingru Zhang, Wenhao Dong, Jing Wang, Han Zhang, Yuefu Wang, Bingyang Ji
Septic shock, a global health concern, boasts high mortality rates. Research exploring the efficacy of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in septic shock remains limited. Our study aimed to establish a rodent model employing VA-ECMO in septic shock rats, assessing the therapeutic impact of VA-ECMO on septic shock. Nineteen Sprague-Dawley rats were randomly assigned to sham, septic shock, and (septic shock + VA-ECMO; SSE) groups. Septic shock was induced by intravenous lipopolysaccharides, confirmed by a mean arterial pressure drop to 25-30% of baseline...
February 20, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#30
EDITORIAL
József Tímár, Andrea Ladányi, Anna Sebestyén, László Kopper
No abstract text is available yet for this article.
2024: Pathology Oncology Research: POR
#31
JOURNAL ARTICLE
Maohui Chen, Yizhou Huang, Shuliang Zhang, Yixiong Zheng, Taidui Zeng, Chun Chen, Bin Zheng
INTRODUCTION: Oesophageal cancer (OC) has higher morbidity and mortality rate than most other malignancies. The standard treatment for unresectable locally advanced oesophageal squamous cell carcinoma (OSCC) is concurrent chemoradiotherapy, with tumour regression observed in a proportion of patients after treatment, but prognostic improvement remains limited. Immunotherapy in combination with chemotherapy (CT) has been shown to be efficacious as the first-line treatment of advanced OC and neoadjuvant therapy...
February 28, 2024: BMJ Open
#32
REVIEW
Arshia Javidan, Muralie Vignarajah, Matthew W Nelms, Fangwen Zhou, Yung Lee, Faysal Naji, Ahmed Kayssi
OBJECTIVE: Due to its video based approach, YouTube has become a widely accessed educational resource for patients and trainees. This systematic review characterised and evaluated the peer reviewed literature investigating YouTube as a source of patient or trainee education in vascular surgery. DATA SOURCES: A comprehensive literature search was conducted using EMBASE, MEDLINE, and Ovid HealthStar from inception until 19 January 2023. All primary studies and conference abstracts evaluating YouTube as a source of vascular surgery education were included...
2024: EJVES vascular forum
#33
REVIEW
Eelco F M Wijdicks
BACKGROUND: The history of the development of acute neurologic disease as a biologic mechanism is of interest. Equally important is how it translated to the bedside and how the clinical examination differentiated itself. METHODS: This paper reviews primary sources pertaining to acute neurologic conditions described mostly in the 19th and 20th century. A review of monographs, treatises, textbooks, and peer-reviewed articles was conducted. RESULTS: The evolution of clinical signs and syndromes associated with dynamic intracranial pathologies was predicated on the idea that animal studies informed clinicians, who then linked clinical signs to these observations...
February 25, 2024: European Journal of Neurology
#34
JOURNAL ARTICLE
Rijul Gupta, Dhanshree R Gunjawate, Duy Duong Nguyen, Craig Jin, Catherine Madill
INTRODUCTION: Over the past decade, several machine learning (ML) algorithms have been investigated to assess their efficacy in detecting voice disorders. Literature indicates that ML algorithms can detect voice disorders with high accuracy. This suggests that ML has the potential to assist clinicians in the analysis and treatment outcome evaluation of voice disorders. However, despite numerous research studies, none of the algorithms have been sufficiently reliable to be used in clinical settings...
February 24, 2024: BMJ Open
#35
REVIEW
Gessica Giusto, Anna Cerullo, Marco Gandini
BACKGROUND: Small bowel obstruction (SBO) is a significant cause of surgery in adult horses presenting with colic pain. SBOs often require resection and anastomosis. While various techniques for intestinal anastomoses have been developed, it remains uncertain if any fully meet our clinical needs. OBJECTIVE: To conduct a scoping review of publications on anastomosis techniques and outcomes for the treatment of SBO. STUDY DESIGN: Scoping review...
February 20, 2024: Equine Veterinary Journal
#36
REVIEW
Joshua Engle, Parastoo Saberi, Paul Bain, Asad Ikram, Magdy Selim, Salil Soman
One of the goals of this systematic review is to provide a meta-analysis-derived mean OEF of healthy volunteers. Another aim of this study is to indicate the OEF ranges of various neurological pathologies. Potential clinical applications of OEF metrics are presented. Peer-reviewed studies reporting OEF metrics derived from computed tomography (CT)/positron emission tomography (PET) and/or magnetic resonance imaging (MRI) were considered. Databases utilized included MEDLINE, PubMed, EMBASE, Web of Science, and Google Scholar...
February 17, 2024: Neurological Sciences
#37
JOURNAL ARTICLE
Wei Xia, Dandan Li, Wenguang He, Perry J Pickhardt, Junming Jian, Rui Zhang, Junjie Zhang, Ruirui Song, Tong Tong, Xiaotang Yang, Xin Gao, Yanfen Cui
"Just Accepted" papers have undergone full peer review and have been accepted for publication in Radiology: Artificial Intelligence . This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content. Purpose To develop a Weakly supervISed model DevelOpment fraMework (WISDOM) to construct a lymph node (LN) diagnosis model for patients with rectal cancer (RC) that uses preoperative MRI data coupled with postoperative patient-level pathologic information...
February 14, 2024: Radiology. Artificial intelligence
#38
JOURNAL ARTICLE
Howell Fu, Alex Novak, Dennis Robert, Shamie Kumar, Swetha Tanamala, Jason Oke, Kanika Bhatia, Ruchir Shah, Andrea Romsauerova, Tilak Das, Abdalá Espinosa, Mariusz Tadeusz Grzeda, Mariapaola Narbone, Rahul Dharmadhikari, Mark Harrison, Kavitha Vimalesvaran, Jane Gooch, Nicholas Woznitza, Nabeeha Salik, Alan Campbell, Farhaan Khan, David J Lowe, Haris Shuaib, Sarim Ather
INTRODUCTION: A non-contrast CT head scan (NCCTH) is the most common cross-sectional imaging investigation requested in the emergency department. Advances in computer vision have led to development of several artificial intelligence (AI) tools to detect abnormalities on NCCTH. These tools are intended to provide clinical decision support for clinicians, rather than stand-alone diagnostic devices. However, validation studies mostly compare AI performance against radiologists, and there is relative paucity of evidence on the impact of AI assistance on other healthcare staff who review NCCTH in their daily clinical practice...
February 12, 2024: BMJ Open
#39
JOURNAL ARTICLE
Michelle O'Donoghue, Norelee Kennedy, John Forbes, Carol-Anne Murphy
PURPOSE: Qualitative engagement with stakeholders in the development of interventions can provide insight into strategies to maximize feasibility in real-life settings. We engaged stakeholders (autistic adults, early childhood educators, early childhood sector leaders and policy influencers, parents of autistic children, and speech-language pathologists) to inform the development of an educator-led peer-mediated intervention (PMI) for autistic preschoolers who use minimal speech that is feasible to implement in inclusive early childhood education and care (ECEC) settings...
February 12, 2024: American Journal of Speech-language Pathology
#40
JOURNAL ARTICLE
Benjamin Gerhardy, Shanthosh Sivapathan, Sam Orde, Lucy Morgan
BACKGROUND: Cardiopulmonary dysfunction is a complex process with a broad range of etiologies. Investigations performed either at rest or those that only assess the function of a single organ (heart or lungs) are often insufficient. A simultaneous cardiopulmonary exercise test with stress echocardiography is a new approach to assessing cardiopulmonary dysfunction as it provides anatomical and functional imaging simultaneously while under increasing stress. To date, the application of cardiopulmonary exercise test-stress echocardiography (CPET-SE) has been broad and without structure, and its effect on patient outcomes is unclear...
February 12, 2024: JMIR Research Protocols
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