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Pathology peer review

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https://www.readbyqxmd.com/read/28913416/using-focused-laboratory-management-and-quality-improvement-projects-to-enhance-resident-training-and-foster-scholarship
#1
Matthew D Krasowski, Bradley A Ford, J Stacey Klutts, Chris S Jensen, Angela S Briggs, Robert A Robinson, Leslie A Bruch, Nitin J Karandikar
Training in patient safety, quality, and management is widely recognized as an important element of graduate medical education. These concepts have been intertwined in pathology graduate medical education for many years, although training programs face challenges in creating explicit learning opportunities in these fields. Tangibly involving pathology residents in management and quality improvement projects has the potential to teach and reinforce key concepts and further fulfill Accreditation Council for Graduate Medical Education goals for pursuing projects related to patient safety and quality improvement...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28910998/abnormal-uterine-bleeding
#2
Ying Cheong, Iain T Cameron, Hilary O D Critchley
Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised, taking into account the improvement of the woman's symptoms and quality of life. Sources of data: Peer-reviewed journals, governmental and professional society publications. Areas of agreement: There is now agreement on a structured, universal approach to the diagnosis of AUB, with the aide memoirs PALM (polyps, adenomyosis, leiomyoma, malignancy) and COEIN (coagulopathies, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified)...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28894688/current-diagnosis-and-management-of-cervical-spondylotic-myelopathy
#3
REVIEW
Joshua Bakhsheshian, Vivek A Mehta, John C Liu
STUDY DESIGN: Review. OBJECTIVES: Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28862431/the-medicinal-chemistry-of-natural-and-semisynthetic-compounds-against-parkinson-s-and-huntington-s-diseases
#4
Enrico Zanforlin, Giuseppe Zagotto, Giovanni Ribaudo
Among the diseases affecting the central nervous system (CNS), neurodegenerations attract the interest of both the clinician and the medicinal chemist. The increasing average age of population, the growing number of patients, and the lack of long-term effective remedies push ahead the quest for novel tools against this class of pathologies. We present a review on the state of the art of the molecules (or combination of molecules) of natural origin that are currently under study against two well-defined pathologies: Parkinson's disease (PD) and Huntington's disease (HD)...
September 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28851799/excisional-treatment-in-women-with-cervical-adenocarcinoma-in-situ-ais-a-prospective-randomised-controlled-non-inferiority-trial-to-compare-ais-persistence-recurrence-after-loop-electrosurgical-excision-procedure-with-cold-knife-cone-biopsy-protocol-for-a-pilot
#5
Paul A Cohen, Alison Brand, Peter Sykes, David C H Wrede, Orla McNally, Lois Eva, Archana Rao, Michael Campion, Martin Stockler, Aime Powell, Jim Codde, Max K Bulsara, Lyndal Anderson, Yee Leung, Louise Farrell, Pennie Stoyles
INTRODUCTION: Adenocarcinoma in situ (AIS) of the uterine cervix is the precursor to invasive endocervical adenocarcinoma. An excisional biopsy such as a cold knife cone biopsy (CKC) should be performed to exclude invasive adenocarcinoma. Loop electrosurgical excision procedure (LEEP) is an alternative modality to CKC but is controversial in AIS. There is a perception that there is a greater likelihood of incomplete excision of AIS with LEEP because the depth of excised tissue tends to be smaller and the tissue margins may show thermal artefact which can interfere with pathology assessment...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28815204/pathology-competencies-for-medical-education-and-educational-cases
#6
Barbara E C Knollmann-Ritschel, Donald P Regula, Michael J Borowitz, Richard Conran, Michael B Prystowsky
Current medical school curricula predominantly facilitate early integration of basic science principles into clinical practice to strengthen diagnostic skills and the ability to make treatment decisions. In addition, they promote life-long learning and understanding of the principles of medical practice. The Pathology Competencies for Medical Education (PCME) were developed in response to a call to action by pathology course directors nationwide to teach medical students pathology principles necessary for the practice of medicine...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28733189/systematic-review-of-serum-steroid-reference-intervals-developed-using-mass-spectrometry
#7
REVIEW
Nevada Tavita, Ronda F Greaves
The aim of this study was to perform a systematic review of the published literature to determine the available serum/plasma steroid reference intervals generated by mass spectrometry (MS) methods across all age groups in healthy subjects and to suggest recommendations to achieve common MS based reference intervals for serum steroids. MEDLINE, EMBASE and PubMed databases were used to conduct a comprehensive search for English language, MS-based reference interval studies for serum/plasma steroids. Selection of steroids to include was based on those listed in the Royal College of Pathologists of Australasia Quality Assurance Programs, Chemical Pathology, Endocrine Program...
July 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28719442/social-media-and-pathology-where-are-we-now-and-why-does-it-matter
#8
James Isom, Meggen Walsh, Jerad M Gardner
Social media has exploded in popularity in recent years. It is a powerful new tool for networking, collaborating, and for the communication and evolution of ideas. It has been increasingly used for business purposes and is now being embraced by physicians including pathologists. Pathology professional organizations and even peer-reviewed pathology journals are now beginning to use social media, as well. There are multiple social media platforms, including Twitter, Facebook, Instagram, LinkedIn, and others. Each platform has different audiences and different ways to share content and interact with other users...
September 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28714184/research-review-what-have-we-learned-about-adolescent-substance-use
#9
REVIEW
Kevin M Gray, Lindsay M Squeglia
BACKGROUND: Adolescence is a critical biological, psychological, and social developmental stage involving heightened risk for substance use and associated adverse consequences. This review, synthesizing emerging findings on this complex topic, is intended to inform research and clinical care focused on adolescents. METHODS: Literature searches were conducted using PubMed, yielding a cross-section of observational and interventional studies focused on adolescent substance use...
July 17, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28713575/wildlife-hosts-for-oie-listed-diseases-considerations-regarding-global-wildlife-trade-and-host-pathogen-relationships
#10
Kristine M Smith, Catherine M Machalaba, Hilary Jones, Paula Cáceres, Marija Popovic, Kevin J Olival, Karim Ben Jebara, William B Karesh
The expanding international wildlife trade, combined with a lack of surveillance for key animal diseases in most countries, represents a potential pathway for transboundary disease movement. While the international wildlife trade represents over US $300 billion per year industry involving exchange of billions of individual animals, animal products, and plants as traditional medicines, meat from wild animals, trophies, live exotic pets, commercial products and food, surveillance and reporting of OIE-Listed diseases in wildlife are often opportunistic...
May 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/28707586/an-overview-of-new-possible-treatments-of-alzheimer-s-disease-based-on-natural-products-and-semi-synthetic-compounds
#11
Enrico Zanforlin, Giuseppe Zagotto, Giovanni Ribaud
BACKGROUND: Dementias and all related neurodegenerative diseases of the Central Nervous System (CNS) are a current issue arousing a great deal of interest in the international scientific community. This is due to the increasing number of patients suffering from these diseases. These pathologies represent a serious problem, not only concerning the quality of life of the patient, but in addition, the enormous economic efforts that society has to do for their treatment. There are currently a few strategies that are available in order to prevent the progression or to mitigate symptoms of the aforementioned diseases...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28697739/effects-of-transcutaneous-electrical-nerve-stimulation-tens-on-proinflammatory-cytokines-protocol-for-systematic-review
#12
Tábata Cristina do Carmo Almeida, Francisco Winter Dos Santos Figueiredo, Valter Cordeiro Barbosa Filho, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami
BACKGROUND: Pain reduction can be achieved by lowering proinflammatory cytokine levels in the blood. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physiotherapeutic resource for pain management, but evidence on the effectiveness of this device at reducing proinflammatory cytokines in the blood is unclear. This study systematically reviews the literature on the effect of TENS on proinflammatory cytokines. METHODS: A systematic review protocol was developed based on searches of articles in six electronic databases and references of retrieved articles, contact with authors, and repositories of clinical trials...
July 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28686500/guidelines-for-pathologic-diagnosis-of-malignant-mesothelioma-2017-update-of-the-consensus-statement-from-the-international-mesothelioma-interest-group
#13
Aliya Noor Husain, Thomas V Colby, Nelson G Ordóñez, Timothy Craig Allen, Richard Luther Attanoos, Mary Beth Beasley, Kelly Jo Butnor, Lucian R Chirieac, Andrew M Churg, Sanja Dacic, Françoise Galateau-Sallé, Allen Gibbs, Allen M Gown, Thomas Krausz, Leslie Anne Litzky, Alberto Marchevsky, Andrew G Nicholson, Victor Louis Roggli, Anupama K Sharma, William D Travis, Ann E Walts, Mark R Wick
CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks. CONCLUSIONS: - There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM...
July 7, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28676008/repurposing-pharmaceuticals-as-neuroprotective-agents-for-cerebral-malaria
#14
Hannah M Brooks, Michael T Hawkes
BACKGROUND: Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection which may result in death or developmental disability. The pathologic processes leading to CM are not fully elucidated; however, widely accepted mechanisms include parasite sequestration, release of infected red blood cell contents, activation of endothelial cells, increased inflammatory responses, and ultimately dysfunction of the neurovascular unit (NVU). The endothelium plays a central role in these processes as the site of parasitized erythrocyte sequestration and as the regulator of fluid extravasation into the central nervous system...
July 4, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28666443/the-effect-of-health-literacy-and-self-management-efficacy-on-the-health-related-quality-of-life-of-hypertensive-patients-in-a-western-rural-area-of-china-a-cross-sectional-study
#15
Chenli Wang, Juntao Lang, Lixia Xuan, Xuemei Li, Liang Zhang
BACKGROUND: Hypertension is a common and frequently occurring chronic disease of the cardiovascular system. Besides the pathological factors, the occurrence and exacerbation of hypertension are also associated with many factors of lifestyle and behaviors. Thus hypertensive patients' Health-related quality of life (HRQL) is not only influenced by the disease itself but also by many subjective factors such as health literacy and self-management efficacy, especially in the deeper part of southwestern China and thus is less developed compared to the other places...
July 1, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28664572/the-use-of-contact-lenses-in-low-vision-rehabilitation-optical-and-therapeutic-applications
#16
REVIEW
Stephen J Vincent
Ocular pathology that manifests at an early age has the potential to alter the vision-dependent emmetropisation mechanism, which co-ordinates ocular growth throughout childhood. The disruption of this feedback mechanism in children with congenital or early-onset visual impairment often results in the development of significant ametropia, including high levels of spherical refractive error, astigmatism and anisometropia. This review examines the use of contact lenses as a refractive correction, low vision aid and therapeutic intervention in the rehabilitation of patients with bilateral, irreversible visual loss due to congenital ocular disease...
June 29, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28647679/factors-impacting-on-psychological-wellbeing-of-international-students-in-the-health-professions-a-scoping-review
#17
REVIEW
Lisa McKenna, Eddie Robinson, Joy Penman, Danny Hills
BACKGROUND: There are increasing numbers of international students undertaking health professional courses, particularly in Western countries. These courses not only expose students to the usual stresses and strains of academic learning, but also require students to undertake clinical placements and practice-based learning. While much is known about general issues facing international students, less is known about factors that impact on those studying in the health professions. OBJECTIVES: To explore what is known about factors that influence the psychological wellbeing of international students in the health professions...
June 17, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28644684/c-cell-and-follicular-epithelial-cell-precursor-lesions-of-the-thyroid
#18
Theresa Scognamiglio
CONTEXT: - The identification of precursor or dysplastic lesions in the thyroid is difficult. Pathology of the C cell has been extensively studied, and the preneoplastic nature of C-cell hyperplasia in the setting of familial medullary thyroid carcinomas is well established. However, the distinction between neoplastic and physiologic/reactive C-cell hyperplasia remains a challenge. Unlike C cells, the existence of a precursor lesion of follicular cell-derived tumors is less well established, and a dysplastic or preneoplastic follicular lesion has not been well defined...
June 23, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28640307/healthy-properties-of-green-and-white-teas-an-update
#19
S Pastoriza, M Mesías, C Cabrera, J A Rufián-Henares
Green tea has been consumed for centuries in Japan, China and Morocco. White tea, which is considered a variety of green tea, is mostly consumed in China and is very appreciated for its flavor. Currently the consumption of both types of tea has been extended to the western countries even as a functional ingredient. A group of polyphenols called catechins stands out among their bioactive components, the most abundant being the (-) epigallocatechin gallate, with high antioxidant power. Teas also contain other phenolic compounds such as gallic, caffeic, chlorogenic or cinnamic acids, quercetin and proanthocyanidols, caffeine, theophylline, l-theanine and minerals such as fluorine, manganese or chromium...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28619773/herbal-medicine-hyeolbuchukeo-tang-or-xuefu-zhuyu-decoction-for-treating-primary-dysmenorrhoea-protocol-for-a-systematic-review-of-randomised-controlled-trials
#20
Junyoung Jo, Jungtae Leem, Jin Moo Lee, Kyoung Sun Park
INTRODUCTION: Primary dysmenorrhoea is menstrual pain without pelvic pathology and is the most common gynaecological condition in women. Xuefu Zhuyudecoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, has been used as a treatment for primary dysmenorrhoea. The purpose of this study is to assess the current published evidence regarding XZD as treatment for primary dysmenorrhoea. MATERIALS AND METHODS: The following databases will be searched from their inception until April 2017: MEDLINE (via PubMed), Allied and Complementary Medicine Database (AMED), EMBASE, The Cochrane Library, six Korean medical databases (Korean Studies Information Service System, DBPia, Oriental Medicine Advanced Searching Integrated System, Research Information Service System, Korea Med and the Korean Traditional Knowledge Portal), three Chinese medical databases (China National Knowledge Infrastructure (CNKI), Wan Fang Database and Chinese Scientific Journals Database (VIP)) and one Japanese medical database (CiNii)...
June 15, 2017: BMJ Open
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