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Pathology peer review

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https://www.readbyqxmd.com/read/29146647/initial-non-operative-management-of-uncomplicated-appendicitis-in-children-a-protocol-for-a-multicentre-randomised-controlled-trial-apac-trial
#1
Max Knaapen, Johanna H van der Lee, Roel Bakx, Sarah-May L The, Ernst W E van Heurn, Hugo A Heij, Ramon R Gorter
INTRODUCTION: Based on epidemiological, immunological and pathology data, the idea that appendicitis is not necessarily a progressive disease is gaining ground. Two types are distinguished: simple and complicated appendicitis. Non-operative treatment (NOT) of children with simple appendicitis has been investigated in several small studies. So far, it is deemed safe. However, its effectiveness and effect on quality of life (QoL) have yet to be established in an adequately powered randomised trial...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145783/ntp-niehs-global-contributions-to-toxicologic-pathology
#2
Robert Sills, Amy Brix, Mark Cesta, Sheba R Churchill, Michelle C Cora, Darlene Dixon, Michael Dykstra, Gordon Flake, Ron Herbert, Ramesh Kovi, Kyathanahalli Janardhan, Angela King-Herbert, David Malarkey, Arun Pandiri, Greg Travlos, Cynthia Willson, Susan A Elmore
National Toxicology Program (NTP) pathologists are engaged in important initiatives that have significant global impact. These initiatives build on its leadership in pathology peer review and publications in the areas of toxicologic pathology, clinical pathology, and laboratory animal medicine. Over the past decade, NTP/National Institute of Environmental Health Sciences research initiatives have focused on cancer and noncancer hazard identification, with the goal of understanding cellular and molecular mechanisms of disease...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29138215/physiology-undergraduate-degree-requirements-in-the-u-s
#3
Valerie S VanRyn, James M Poteracki, Erica A Wehrwein
Course-level learning objectives and core concepts for undergraduate physiology teaching exist. The next step is to consider how these resources fit into generalizable program-level guidelines for Bachelor of Science (BS) degrees in Physiology. In the absence of program-level guidelines for Physiology degree programs, we compiled a selective internal report to review degree requirements from 18 peer BS programs entitled "Physiology" in the United States (U.S.). There was a range of zero to three required semesters of math, physics, physics laboratory, general biology, biology laboratory, general chemistry, chemistry laboratory, organic chemistry, organic chemistry laboratory, biochemistry, biochemistry laboratory, anatomy, anatomy laboratory, core systems physiology, and physiology laboratory...
December 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/29138205/long-term-prognosis-of-young-breast-cancer-patients-%C3%A2-40-years-who-did-not-receive-adjuvant-systemic-treatment-protocol-for-the-paradigm-initiative-cohort-study
#4
Gwen Mhe Dackus, Natalie D Ter Hoeve, Mark Opdam, Willem Vreuls, Zsuzsanna Varga, Esther Koop, Stefan M Willems, Carolien Hm Van Deurzen, Emilie J Groen, Alicia Cordoba, Jos Bart, Antien L Mooyaart, Jan G van den Tweel, Vicky Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Frederic Amant, Annegien Broeks, Ron Kerkhoven, Nikolas Stathonikos, Mitko Veta, Adri Voogd, Katarzyna Jozwiak, Michael Hauptmann, Marlous Hoogstraat, Marjanka K Schmidt, Gabe Sonke, Elsken van der Wall, Sabine Siesling, Paul J van Diest, Sabine C Linn
INTRODUCTION: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered prognostically unfavourable, many treatment guidelines recommend adjuvant systemic treatment for all young patients. Patients cured by locoregional treatment alone are, therefore, overtreated. Lack of prognosticators for young breast cancer patients represents an unmet medical need and has led to the initiation of the PAtients with bReAst cancer DIaGnosed preMenopausally (PARADIGM) initiative...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29125941/epitranscriptomics-regulation-of-mrna-metabolism-through-modifications
#5
REVIEW
Eyal Peer, Gideon Rechavi, Dan Dominissini
Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N(6)-methyladenosine (m(6)A), paved the way for the deciphering of other types of mRNA modifications, such as N(1)-methyladenosine (m(1)A)...
November 7, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29114633/surgical-management-of-degenerative-meniscus-lesions-the-2016-esska-meniscus-consensus
#6
P Beaufils, R Becker, S Kopf, M Englund, R Verdonk, M Ollivier, R Seil
Purpose  A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscopic partial meniscectomy compared to non-operative treatment, sham surgery or sham arthroscopic partial meniscectomy...
June 2017: Joints
https://www.readbyqxmd.com/read/29101994/acr-appropriateness-criteria-%C3%A2-thoracic-aorta-interventional-planning-and-follow-up
#7
Gregory Bonci, Michael L Steigner, Michael Hanley, Aaron R Braun, Benoit Desjardins, Ron C Gaba, Kenneth L Gage, Jon S Matsumura, Eric E Roselli, David M Sella, Richard Strax, Nupur Verma, Clifford R Weiss, Karin E Dill
Thoracic endovascular aortic repair (TEVAR) has undergone rapid evolution and is now applied to a range of aortic pathologies. Imaging plays a vital role in the pre- and postintervention assessment of TEVAR patients. Accurate characterization of pathology and evaluation for high-risk anatomic features are necessary in the planning phase, and careful assessment for graft stability, aortic lumen diameter, and presence of endoleak are paramount in the follow-up period. CTA is the imaging modality of choice for pre- and postintervention assessment, and MRA is an acceptable alternative depending on patient stability and graft composition...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101992/acr-appropriateness-criteria-%C3%A2-sinonasal-disease
#8
Claudia F E Kirsch, Julie Bykowski, Joseph M Aulino, Kevin L Berger, Asim F Choudhri, David B Conley, Michael D Luttrull, Diego Nunez, Lubdha M Shah, Aseem Sharma, Vilaas S Shetty, Rathan M Subramaniam, Sophia C Symko, Rebecca S Cornelius
Imaging of sinonasal pathology may occur for assessment of rhinosinusitis or mass lesions. Rhinosinusitis is prevalent in up to 16% of the US population with annual economic burdens estimated at 22 billion dollars. Rhinosinusitis is characterized as acute or chronic based on symptom duration; if four or more episodes occur annually, the term recurrent acute rhinosinusitis (RARS) is used. In acute uncomplicated rhinosinusitis when inflammatory change remains in the paranasal sinuses and nasal cavity, imaging may not be required...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101582/most-cited-publications-in-oral-and-maxillofacial-surgery-a-bibliometric-analysis
#9
Nawaf Aslam-Pervez, Joshua E Lubek
BACKGROUND: Citation is one of the most important forms of acknowledgment and recognition received by our peers in academia. This study identifies and characterizes the current topmost highly cited publications in journals specifically dedicated to the specialty. The purpose of this study is to identify, using the citation count, works that have made key contributions in the field and to provide insight into the direction the specialty has taken in the last 30 years. METHODS: Four journals that were dedicated to the field of oral and maxillofacial surgery (OMFS) were selected...
November 4, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29061632/neoadjuvant-s-1-with-concurrent-radiotherapy-followed-by-surgery-for-borderline-resectable-pancreatic-cancer-study-protocol-for-an-open-label-multicentre-prospective-phase-ii-trial-jaspac05
#10
Shinichiro Takahashi, Izumi Ohno, Masafumi Ikeda, Tatsushi Kobayashi, Tetsuo Akimoto, Motohiro Kojima, Masaru Konishi, Katsuhiko Uesaka
INTRODUCTION: Borderline resectable pancreatic cancer (BRPC) can involve the portal vein, superior mesenteric vein, superior mesenteric artery, coeliac axis or hepatic artery, and has a high probability of positive surgical margins and poor prognosis after resection. Neoadjuvant chemoradiation is expected to provide substantial local control and prolong survival in patients with BRPC. METHODS AND ANALYSIS: This open-label, multicentre, prospective phase II trial will assess S-1 with concurrent radiotherapy as preoperative treatment for BRPC...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29043847/smoking-related-interstitial-fibrosis-evidence-of-radiologic-regression-with-advancing-age-and-smoking-cessation
#11
Aurélie Fabre, Ann Treacy, Lisa P Lavelle, Maciek Narski, Nazia Faheem, David Healy, Jonathan D Dodd, Michael P Keane, James J Egan, Gilles Jebrak, Hervé Mal, Marcus W Butler
More data are needed regarding the radiology, co-morbidities and natural history of smoking-related interstitial fibrosis (SRIF), a common pathological finding, mainly described heretofore in association with lung cancer, where respiratory bronchiolitis (RB) usually co-exists. We prospectively acquired high resolution CT scan data (edge-enhancing lung reconstructions) to detect any radiologic interstitial lung abnormality (ILA) in individuals who ultimately underwent surgical lobectomy for lung cancer (n = 20), for radiologic/pathologic correlation...
October 18, 2017: COPD
https://www.readbyqxmd.com/read/29030263/the-role-of-endemic-plants-in-mauritian-traditional-medicine-potential-therapeutic-benefits-or-placebo-effect
#12
REVIEW
Nawraj Rummun, Vidushi S Neergheen-Bhujun, Kersley B Pynee, Cláudia Baider, Theeshan Bahorun
ETHNOPHARMACOLOGICAL RELEVANCE: The Mauritian endemic flora has been recorded to be used as medicines for nearly 300 years. Despite acceptance of these endemic plants among the local population, proper documentation of their therapeutic uses is scarce. This review aims at summarising documented traditional uses of Mauritian endemic species with existing scientific data of their alleged bioactivities, in a view to appeal for more stringent validations for their ethnomedicinal uses. MATERIAL AND METHODS: A comprehensive bibliographic investigation was carried out by analysing published books on ethnopharmacology and international peer-reviewed papers via scientific databases namely ScienceDirect and PubMed...
October 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28964742/umbilical-cord-mesenchymal-stromal-cell-transplantations-a-systemic-analysis-of-clinical-trials
#13
REVIEW
Alp Can, Ferda Topal Celikkan, Ozgur Cinar
The advances and success of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in experimental disease animal models have fueled the development of targeted therapies in humans. The therapeutic potential of allogeneic transplantation of UC-MSCs has been under examination since 2009. The purpose of this systematic analysis was to review the published results, limitations and obstacles for UC-MSC transplantation. An extensive search strategy was applied to the published literature, 93 peer-reviewed full-text articles and abstracts were found published by early August 2017 that investigated the safety, efficacy and feasibility of UC-MSCs in 2001 patients with 53 distinct pathologies including many systemic/local, acute/chronic conditions...
September 28, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28913416/using-focused-laboratory-management-and-quality-improvement-projects-to-enhance-resident-training-and-foster-scholarship
#14
Matthew D Krasowski, Bradley A Ford, J Stacey Klutts, Chris S Jensen, Angela S Briggs, Robert A Robinson, Leslie A Bruch, Nitin J Karandikar
Training in patient safety, quality, and management is widely recognized as an important element of graduate medical education. These concepts have been intertwined in pathology graduate medical education for many years, although training programs face challenges in creating explicit learning opportunities in these fields. Tangibly involving pathology residents in management and quality improvement projects has the potential to teach and reinforce key concepts and further fulfill Accreditation Council for Graduate Medical Education goals for pursuing projects related to patient safety and quality improvement...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28910998/abnormal-uterine-bleeding
#15
Ying Cheong, Iain T Cameron, Hilary O D Critchley
Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised, taking into account the improvement of the woman's symptoms and quality of life. Sources of data: Peer-reviewed journals, governmental and professional society publications. Areas of agreement: There is now agreement on a structured, universal approach to the diagnosis of AUB, with the aide memoirs PALM (polyps, adenomyosis, leiomyoma, malignancy) and COEIN (coagulopathies, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified)...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28894688/current-diagnosis-and-management-of-cervical-spondylotic-myelopathy
#16
REVIEW
Joshua Bakhsheshian, Vivek A Mehta, John C Liu
STUDY DESIGN: Review. OBJECTIVES: Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28862431/the-medicinal-chemistry-of-natural-and-semisynthetic-compounds-against-parkinson-s-and-huntington-s-diseases
#17
Enrico Zanforlin, Giuseppe Zagotto, Giovanni Ribaudo
Among the diseases affecting the central nervous system (CNS), neurodegenerations attract the interest of both the clinician and the medicinal chemist. The increasing average age of population, the growing number of patients, and the lack of long-term effective remedies push ahead the quest for novel tools against this class of pathologies. We present a review on the state of the art of the molecules (or combination of molecules) of natural origin that are currently under study against two well-defined pathologies: Parkinson's disease (PD) and Huntington's disease (HD)...
September 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28851799/excisional-treatment-in-women-with-cervical-adenocarcinoma-in-situ-ais-a-prospective-randomised-controlled-non-inferiority-trial-to-compare-ais-persistence-recurrence-after-loop-electrosurgical-excision-procedure-with-cold-knife-cone-biopsy-protocol-for-a-pilot
#18
Paul A Cohen, Alison Brand, Peter Sykes, David C H Wrede, Orla McNally, Lois Eva, Archana Rao, Michael Campion, Martin Stockler, Aime Powell, Jim Codde, Max K Bulsara, Lyndal Anderson, Yee Leung, Louise Farrell, Pennie Stoyles
INTRODUCTION: Adenocarcinoma in situ (AIS) of the uterine cervix is the precursor to invasive endocervical adenocarcinoma. An excisional biopsy such as a cold knife cone biopsy (CKC) should be performed to exclude invasive adenocarcinoma. Loop electrosurgical excision procedure (LEEP) is an alternative modality to CKC but is controversial in AIS. There is a perception that there is a greater likelihood of incomplete excision of AIS with LEEP because the depth of excised tissue tends to be smaller and the tissue margins may show thermal artefact which can interfere with pathology assessment...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28815204/pathology-competencies-for-medical-education-and-educational-cases
#19
Barbara E C Knollmann-Ritschel, Donald P Regula, Michael J Borowitz, Richard Conran, Michael B Prystowsky
Current medical school curricula predominantly facilitate early integration of basic science principles into clinical practice to strengthen diagnostic skills and the ability to make treatment decisions. In addition, they promote life-long learning and understanding of the principles of medical practice. The Pathology Competencies for Medical Education (PCME) were developed in response to a call to action by pathology course directors nationwide to teach medical students pathology principles necessary for the practice of medicine...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28733189/systematic-review-of-serum-steroid-reference-intervals-developed-using-mass-spectrometry
#20
REVIEW
Nevada Tavita, Ronda F Greaves
The aim of this study was to perform a systematic review of the published literature to determine the available serum/plasma steroid reference intervals generated by mass spectrometry (MS) methods across all age groups in healthy subjects and to suggest recommendations to achieve common MS based reference intervals for serum steroids. MEDLINE, EMBASE and PubMed databases were used to conduct a comprehensive search for English language, MS-based reference interval studies for serum/plasma steroids. Selection of steroids to include was based on those listed in the Royal College of Pathologists of Australasia Quality Assurance Programs, Chemical Pathology, Endocrine Program...
July 19, 2017: Clinical Biochemistry
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