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https://www.readbyqxmd.com/read/29786864/testing-the-roles-of-vertical-transmission-and-drought-stress-in-the-prevalence-of-heritable-fungal-endophytes-in-annual-grass-populations
#1
Brittany R Cavazos, Teresa F Bohner, Marion L Donald, Michelle E Sneck, Alan Shadow, Marina Omacini, Jennifer A Rudgers, Tom E X Miller
Beneficial inherited symbionts are expected to reach high prevalence in host populations, yet many are observed at intermediate prevalence. Theory predicts that a balance of fitness benefits and efficiency of vertical transmission may interact to stabilize intermediate prevalence. We established populations of grass hosts (Lolium multiflorum) that varied in prevalence of a heritable fungal endophyte (Epichloё occultans), allowing us to infer long-term equilibria by tracking change in prevalence over one generation...
May 22, 2018: New Phytologist
https://www.readbyqxmd.com/read/29786746/luteolin-induces-myelodysplastic-syndrome%C3%A2-derived-cell-apoptosis-via-the-p53%C3%A2-dependent-mitochondrial-signaling-pathway-mediated-by-reactive-oxygen-species
#2
Weimin Dong, Yan Lin, Yang Cao, Yue Liu, Xiaobao Xie, Weiying Gu
Luteolin, a common dietary flavonoid, induces the apoptosis of cells in several types of cancer. However, its role in myelodysplastic syndrome (MDS) and the potential underlying mechanisms remain to be elucidated. To evaluate the potential benefit and underlying mechanisms of luteolin in MDS cells, the viability of SKM‑1 cells and primary bone marrow (PBM) mononuclear cells from patients with intermediate‑ or high‑risk MDS were assessed using a Cell Counting Kit‑8 assay. The apoptotic features of cell morphology were assessed using Wright‑Giemsa staining, DNA fragmentation was analyzed by agarose gel electrophoresis, and the extent of apoptosis was quantified by flow cytometry (FCM)...
May 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29785320/iron-catalyzed-direct-olefin-diazidation-via-peroxyester-activation-promoted-by-nitrogen-based-ligands
#3
Shou-Jie Shen, Cheng-Liang Zhu, Deng-Fu Lu, Hao Xu
We herein report an iron-catalyzed direct diazidation method via activation of bench-stable peroxyesters promoted by nitrogen-based ligands. This method is effective for a broad range of olefins and N -heterocycles, including those that are difficult substrates for the existing olefin diamination and diazidation methods. Notably, nearly a stoichiometric amount of oxidant and TMSN3 are sufficient for high-yielding diazidation for most substrates. Preliminary mechanistic studies elucidated the similarities and differences between this method and the benziodoxole-based olefin diazidation method previously developed by us...
May 4, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29785078/detection-of-hyper-conserved-regions-in-hepatitis-b-virus-x-gene-potentially-useful-for-gene-therapy
#4
Carolina González, David Tabernero, Maria Francesca Cortese, Josep Gregori, Rosario Casillas, Mar Riveiro-Barciela, Cristina Godoy, Sara Sopena, Ariadna Rando, Marçal Yll, Rosa Lopez-Martinez, Josep Quer, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías
AIM: To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene ( HBX ) 5' region that could be candidates for gene therapy. METHODS: The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/mL, the HBX 5' end region [nucleotide (nt) 1255-1611] was PCR-amplified and submitted to next-generation sequencing (NGS)...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29784860/molecular-and-functional-characterization-of-fc%C3%AE-riiib-receptor-ligand-interaction-implications-for-neutrophil-mediated-immune-mechanisms-in-malaria
#5
Piyapong Simtong, Amornrat V Romphruk, Annalena Traum, Monika Burg-Roderfeld, Gregor Bein, Konstantin Jakubowski, Andreas Dominik, Michael Theisen, Ikhlaq Hussain Kana, Ulrich J Sachs, Sentot Santoso
The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing HNA-1aa, -1bb, and -1bc. Of these, cells expressing HNA-1bc interacted significantly stronger (2.277 versus 0.743) with human IgG than cells expressing the HNA-1aa or -1bb alloforms. The higher affinity of IgG towards the HNA-1c alloform was confirmed using neutrophils derived from German blood donors...
May 21, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29784357/a-sensitively-non-enzymatic-amperometric-sensor-and-its-application-in-living-cell-superoxide-anion-radical-detection
#6
Xinhe Liu, Miaomiao Ran, Guoan Liu, Xiuhui Liu, Zhonghua Xue, Xiaoquan Lu
Here, we report a nanocomposite composed of silver nanoparticles and multi-walled carbon nanotubes (AgNPs/MWNTs) utilized as an efficient electrode material for sensitive detection superoxide anion (O2 •- ). The procedure to synthesize AgNPs/MWNTs nanocomposites was green and facile. In the presence of functionalized multi-wall carbon nanotubes (MWNTs), silver nanoparticles (AgNPs) were in situ generated by chemical reduction of silver nitrate with glucose as a reducing and stabilizing agent to give the desired AgNPs/MWNTs nanocomposites...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784340/quantitative-study-of-the-mineralogical-composition-of-mineral-dust-aerosols-by-x-ray-diffraction
#7
Sophie Nowak, Sandra Lafon, Sandrine Caquineau, Emilie Journet, Benoit Laurent
Mineral dust aerosols, produced by wind erosion in arid regions and semi-arid surfaces, are important components of the atmosphere that affect the Earth radiative budget, atmospheric chemistry and biogeochemical cycles. Dust aerosol particles are composed of a complex mixture of various minerals, mainly clays, calcite, quartz, feldspars and iron oxides. The nature and the relative abundance of the minerals are key parameters to evaluate mineral dust environmental impacts. Strong limitations remain to quantify the mineralogical composition of dust particles, mainly due to the low mass of in-situ collected dust particle samples...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783823/-phenotypic-and-genotypic-spectra-of-patients-with-glucose-6-phosphate-dehydrogenase-deficiency-gene-known-pathogenic-variants-a-single-center-study
#8
X Chen, L Yang, H J Wang, B B Wu, Y L Lu, X R Dong, W H Zhou
Objective: To analyze the hotspots of known pathogenic disease-causing variants of glucose-6-phosphate dehydrogenase (G6PD) and the phenotype spectrum of neonatal patients with known pathogenic disease-causing variants of G6PD. Methods: The known pathogenic disease-causing variants of G6PD were collected from Human Gene Mutation Database. Screening was performed for these variants among the 7 966 cases (2 357 neonatal, 5 609 non-neonatal) in the database of sequencing at Molecular Diagnosis Center, Children's Hospital of Fudan University...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783668/a-comprehensive-characterization-of-a-10-at-yb-ysag-laser-ceramic-sample
#9
Angela Pirri, Guido Toci, Jiang Li, Yagang Feng, Tengfei Xie, Zhaoxiang Yang, Barbara Patrizi, Matteo Vannini
We report a comprehensive characterization of a 10 at.% Yb3+ -doped YSAG (Yb:Y₃Scx Al(5-x) O12 , x = 1.5) ceramic, including microstructural, spectroscopic and laser properties. Moreover, we illustrate and discuss the fabrication technique. Yb3+ in YSAG features a broader absorption and emission band than in traditional YAG, which is advantageous for laser applications (i.e., tunable laser sources, ultrafast pulse generation). Pumping in a quasi continuous wave regime at 936 nm, the ceramic has shown good laser performance as the maximum output power was 6...
May 18, 2018: Materials
https://www.readbyqxmd.com/read/29782667/synergies-of-electrochemical-metallization-and-valance-change-in-all-inorganic-perovskite-quantum-dots-for-resistive-switching
#10
Yan Wang, Ziyu Lv, Qiufan Liao, Haiquan Shan, Jinrui Chen, Ye Zhou, Li Zhou, Xiaoli Chen, Vellaisamy A L Roy, Zhanpeng Wang, Zongxiang Xu, Yu-Jia Zeng, Su-Ting Han
The in-depth understanding of ions' generation and movement inside all-inorganic perovskite quantum dots (CsPbBr3 QDs), which may lead to a paradigm to break through the conventional von Neumann bottleneck, is strictly limited. Here, it is shown that formation and annihilation of metal conductive filaments and Br- ion vacancy filaments driven by an external electric field and light irradiation can lead to pronounced resistive-switching effects. Verified by field-emission scanning electron microscopy as well as energy-dispersive X-ray spectroscopy analysis, the resistive switching behavior of CsPbBr3 QD-based photonic resistive random-access memory (RRAM) is initiated by the electrochemical metallization and valance change...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782494/ubiquitin-dependent-proteolysis-of-cxcl7-leads-to-posterior-longitudinal-ligament-ossification
#11
Michiyo Tsuru, Atsushi Ono, Hideaki Umeyama, Masahiro Takeuchi, Kensei Nagata
Ossification of the posterior longitudinal ligament (OPLL), a spinal ligament, reduces the range of motion in limbs. No treatment is currently available for OPLL, which is why therapies are urgently needed. OPLL occurs in obesity, is more common in men, and has an onset after 40 years of age. The mechanisms underlying OPLL remain unclear. In this study, we performed a serum proteomic analysis in both OPLL patients and healthy subjects to identify factors potentially involved in the development of OPLL, and found reduced levels of a protein that might underlie the pathology of OPLL...
2018: PloS One
https://www.readbyqxmd.com/read/29781267/highly-regular-uniform-k-3-scf-6-mn-4-phosphors-facile-synthesis-microstructures-photo-luminescence-properties-and-application-in-led-devices
#12
Hong Ming, Shuifu Liu, Lili Liu, Jiaqing Peng, Junxiang Fu, Fu Du, Xinyu Ye
A new generation of red phosphors of complex fluoride matrices activated with Mn4+ , has gained a broad interest in getting high color rendering index (CRI), low correlated color temperature (CCT) of white light-emitting diodes(WLEDs). However, besides their instability towards moisture, the extremely irregular and nonuniform morphologies of these phosphors have limited their practical industry applications. In the present study, a novel type of K3 ScF6 :Mn4+ red phosphor with highly regular, uniform and high color purity was synthesized successfully via a facile two-step co-precipitation method under mild conditions...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29781019/complex-strain-induced-structural-changes-observed-in-fibrin-assembled-in-human-plasma
#13
G Portale, J Torbet
The structure of the core scaffold of blood clots, the interlinked 3-dimensional network of fibrin fibers, is modified by mechanical forces generated by platelet driven clot retraction, wound repair and shear stress through blood flow. Here X-ray diffraction is used to investigate how uniaxial strain, ε (ε = extension/original length), alters fiber structure in highly aligned human plasma clots covalently cross-linked by Factor XIIIa. Three stretch sensitive axially repeating structures are identified. Firstly, the foundation structure with an initial ≈22 nm axial repeat stretches, fades then disappears at ε ≈ 0...
May 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29780802/exploring-the-potential-of-generative-adversarial-networks-for-synthesizing-radiological-images-of-the-spine-to-be-used-in-in-silico-trials
#14
Fabio Galbusera, Frank Niemeyer, Maike Seyfried, Tito Bassani, Gloria Casaroli, Annette Kienle, Hans-Joachim Wilke
In silico trials recently emerged as a disruptive technology, which may reduce the costs related to the development and marketing approval of novel medical technologies, as well as shortening their time-to-market. In these trials, virtual patients are recruited from a large database and their response to the therapy, such as the implantation of a medical device, is simulated by means of numerical models. In this work, we propose the use of generative adversarial networks to produce synthetic radiological images to be used in in silico trials...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29780503/a-high-throughput-screening-method-for-the-nano-crystallization-of-salts-of-organic-cations
#15
Philipp P Nievergelt, Martin Babor, Jan Čejka, Bernhard Spingler
The generation of solid salts of organic molecules is important to the chemical and pharmaceutical industry. Commonly used salt screening methods consume a lot of resources. We employed a combination of ion exchange screening and vapour diffusion for crystallization. This technique is semi-automatic and requires just nanoliters of the solution of the analyte to be crystallized. This high throughput screening yielded single crystals of sufficient size and quality for single-crystal X-ray structure determination using an in-house X-ray diffractometer...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780501/a-bi-terminal-protein-ligation-strategy-to-probe-chromatin-structure-during-dna-damage
#16
Sinan Kilic, Iuliia Boichenko, Carolin C Lechner, Beat Fierz
The cellular response to DNA damage results in a signaling cascade that primes chromatin for repair. Combinatorial post-translational modifications (PTMs) play an important role in this process by altering the physical properties of chromatin and recruiting downstream factors. One key signal integrator is the histone variant H2A.X, which is phosphorylated at a C-terminal serine (S139ph), and ubiquitylated within its N-terminal tail at lysines 13 and 15 (K13/15ub). How these PTMs directly impact chromatin structure and thereby facilitate DNA repair is not well understood...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780453/-cis-oxoruthenium-complexes-supported-by-chiral-tetradentate-amine-n-4-ligands-for-hydrocarbon-oxidations
#17
Chun-Wai Tse, Yungen Liu, Toby Wai-Shan Chow, Chaoqun Ma, Wing-Ping Yip, Xiao-Yong Chang, Kam-Hung Low, Jie-Sheng Huang, Chi-Ming Che
We report the first examples of ruthenium complexes cis -[(N4 )RuIII Cl2 ]+ and cis -[(N4 )RuII (OH2 )2 ]2+ supported by chiral tetradentate amine ligands (N4 ), together with a high-valent cis -dioxo complex cis -[(N4 )RuVI (O)2 ]2+ supported by the chiral N4 ligand mcp (mcp = N , N '-dimethyl- N , N '-bis(pyridin-2-ylmethyl)cyclohexane-1,2-diamine). The X-ray crystal structures of cis -[(mcp)RuIII Cl2 ](ClO4 ) ( 1a ), cis -[(Me2 mcp)RuIII Cl2 ]ClO4 ( 2a ) and cis -[(pdp)RuIII Cl2 ](ClO4 ) ( 3a ) (Me2 mcp = N , N '-dimethyl- N , N '-bis((6-methylpyridin-2-yl)methyl)cyclohexane-1,2-diamine, pdp = 1,1'-bis(pyridin-2-ylmethyl)-2,2'-bipyrrolidine)) show that the ligands coordinate to the ruthenium centre in a cis -α configuration...
March 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780339/your-co-author-received-150-citations-pride-but-not-envy-mediates-the-effect-of-system-generated-achievement-messages-on-motivation
#18
Sonja Utz, Nicole L Muscanell
ResearchGate, a social network site for academics, prominently displays the achievements of people one follows ("With 150 new reads, X was the most read author from their institute"). The goal of this paper was to examine the emotional and motivational effects of these system-generated messages, thereby extending prior research on envy-evoking status updates on Facebook to a professional context. We also extend the research on social comparisons and more broadly, on emotional responses elicited by social media...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29779660/in-vitro-analysis-of-cyanobacterial-nonheme-iron-dependent-aliphatic-halogenases-welo5-and-ambo5
#19
Xinyu Liu
Aliphatic carbon-halogen (C-X) bonds are prevalent in modern pharmaceuticals and bioactive natural products. Three distinct chemical strategies are known in Nature to generate these structural motifs. The first is via the nucleophilic substitution at a prefunctionalized electrophilic carbon center with a halide anion (X- ), known for the S-adenosyl-l-methionine-dependent halogenases. The second is via the electrophilic activation of an alkene or its equivalent by a halenium ion (X+ ) donor, known for the haloperoxidases and flavin-dependent halogenases...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29779353/-using-target-next-generation-sequencing-assay-in-diagnosing-of-46-patients-with-suspected-congenital-anemias
#20
Y Li, G X Peng, Q Y Gao, Y Li, L Ye, J P Li, L Song, H H Fan, Y Yang, Y Z Xiong, Z J Wu, W R Yang, K Zhou, X Zhao, L P Jing, F K Zhang, L Zhang
Objective: To evaluate the impact of the targeted next-generation sequencing (NGS) assay for difficult congenital anemias. Methods: Blood Disease Hospital Anemia Panel 2014 (BDHAP-2014) including 217 known genes of congenital anemias was developed. NGS and parental verification were performed for patients who were suspected diagnosed with congenital anaemia from August 2014 to July 2017. Results: A total of 46 patients were enrolled in this study, the clinical suspection were 11 cases Fanconi anemia (FA), 8 cases congenital dyserythropoietic anemia (CDA), 6 cases congenital sideroblast anemia (CSA), 12 cases congenital hemolytic anemia (CHA), 1 case dyskeratosis congenital (DC), 4 cases iron-refractory iron deficiency anemia and 4 cases unexplained cytopenia (Uc), respectively...
May 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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