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https://www.readbyqxmd.com/read/28320130/spg2-mimicking-multiple-sclerosis-in-a-family-identified-using-next-generation-sequencing
#1
Anna Rubegni, Carla Battisti, Alessandra Tessa, Alfonso Cerase, Stefano Doccini, Alessandro Malandrini, Filippo M Santorelli, Antonio Federico
Several single gene disorders can potentially be overlooked in the differential diagnostic evaluation of patients with multiple sclerosis (MS). Pelizaeus-Merzbacher disease and spastic paraplegia type 2 are allelic X-linked disorders associated with defective myelination of the central nervous system and mutations in PLP1. Neurological symptoms are occasionally observed in female carriers of these mutations. Two women - the proposita (Pt1) and her mother (Pt2) - reported walking difficulties since adolescence and showed progressive cognitive decline...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319661/atomistic-insights-into-nucleation-and-formation-of-hexagonal-boron-nitride-on-ni-from-first-principles-based-reactive-molecular-dynamics-simulations
#2
Song Liu, Adri C T van Duin, Diana M van Duin, Bin Liu, James H Edgar
Atomistic-scale insights into the growth of a continuous, atomically thin hexagonal boron nitride (hBN) lattice from elemental boron and nitrogen on Ni substrates were obtained from multi-scale modeling combining density functional theory (DFT) and reactive molecular dynamics (rMD). The quantum mechanical calculations focused on the adsorption and reaction energetics for the hBN building-block species, i.e., atomic B, N, BxNy (x, y = 1-2), on Ni(111) and Ni(211), and the diffusion pathways of elemental B and N on these slab model surfaces and in the sublayer...
March 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28319324/future-of-robotic-surgery-in-urology
#3
Jens J Rassweiler, Riccardo Autorino, Jan Klein, Alex Mottrie, Ali Serdar Goezen, Jens-Uwe Stolzenburg, Koon H Rha, Marc Schurr, Jihad Kaouk, Vipul Patel, Prokar Dasgupta, Evangelos Liatsikos
OBJECTIVES: To provide a comprehensive overview of the current status and future perspectives in the field of robotic systems for urologic surgery. MATERIALS AND METHODS: A non-systematic literature review was performed by using PubMed / Medline search electronic engines. Existing patents for robotic devices were researched using the Google search machine. Findings were critically analyzed also by taking into account personal experience of the authors. RESULTS: Relevant patents of the first generation of the da Vinci platform will expire in 2019...
March 20, 2017: BJU International
https://www.readbyqxmd.com/read/28319294/activation-of-sf6-at-platinum-complexes-formation-of-sf3-derivatives-and-their-application-in-deoxyfluorination-reactions
#4
Claudia Berg, Thomas Braun, Mike Ahrens, Philipp Wittwer, Roy Herrmann
The activation of SF6 at [Pt(PR3 )2 ] R=Cy, iPr complexes in the presence of PR3 led selectively and in an unprecedented reaction route to the generation of the SF3 complexes trans-[Pt(F)(SF3 )(PR3 )2 ]. These can also be synthesized from SF4 and the SF2 derivative trans-[Pt(F)(SF2 )(PCy3 )2 ][BF4 ] was characterized by X-ray crystallography. trans-[Pt(F)(SF3 )(PR3 )2 ] complexes are useful tools for deoxyfluorination reactions and novel fluorido complexes bearing a SOF ligand are formed. Based on these studies a process for the deoxyfluorination of ketones was developed with SF6 as fluorinating agent...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28318195/-serratia-infections-should-we-think-about-primary-immunodeficiencies
#5
Alicia Montaner Ramón, Laura Murillo Sanjuán, Cristina Martínez Faci, Carmelo Guerrero Laleona, Carmen Rodríguez-Vigil Iturrate
Chronic granulomatous disease (CGD) is a primary immunodeficiency with an incidence of 1/200,000-250,000 live births. CGD affects mainly male patients, most of the mutations being X-linked, and autosomal recessive forms occur more frequently in communities with greater numbers of consanguineous marriages. CGD is characterized by sensitivity to recurrent and severe bacterial and fungal infections, with formation of granulomas due to the inability of phagocytes to generate reactive oxygen compounds, necessary for the intracellular death of phagocytic microorganisms...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317974/a-second-order-nonlinear-optical-material-with-a-5-fold-interpenetrating-diamondoid-framework-based-on-two-achiral-precursors-spontaneous-resolution-to-absolute-chiral-induction
#6
Zhenzhen Shi, Ling Qin, Hegen Zheng
A pair of new enantiomeric Zn(ii) complexes with 5-fold interpenetrating diamondoid frameworks have been synthesized using two achiral tritopic and V-shaped ligands through spontaneous resolution, which crystallize in orthorhombic crystal systems with chiral P212121 space groups, showing a strong second harmonic generation response. In the presence of enantiopure propane-1,2-diol as a chiral inducing agent, they are driven to controllable homochiral crystallization of the desired enantiomorph, confirmed by single crystal X-ray diffraction and circular dichroism spectroscopy...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28317966/ethylene-polymerization-catalyzed-by-bridging-ni-zn-heterobimetallics
#7
Hsin-Chun Chiu, Arijit Koley, Peter L Dunn, Ryan J Hue, Ian A Tonks
The effect of proximal Zn halides on Ni-catalyzed ethylene polymerization is reported in this work. A series of (NON)NiLX (NON = 2,6-bis-((2,6-diisopropylphenyl)imino)methyl phenoxide; LX = methallyl or L = py, X = tolyl, 2-4) ethylene polymerization precatalysts have been synthesized, as well as a heterobimetallic Ni/Zn complex, (NON)Ni(C4H7)ZnBr2 (5). Each precatalyst could be activated (or promoted) by ZnX2 (X = Cl, Br, Et) to polymerize ethylene. In situ recruitment of ZnX2 by the free imine binding pocket of the NON complexes results in the generation of heterobimetallic active species that produce lower Mn polyethylene than monometallic controls...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28317911/chimeric-viruses-between-rocio-and-west-nile-the-role-for-rocio-prm-e-proteins-in-virulence-and-inhibition-of-interferon-%C3%AE-%C3%AE-signaling
#8
Alberto A Amarilla, Yin X Setoh, Parthiban Periasamy, Nias Y Peng, Gabor Pali, Luiz T Figueiredo, Alexander A Khromykh, Victor H Aquino
Mosquito-transmitted flavivirus Rocio (ROCV) was responsible for an outbreak of encephalitis in the Ribeira Valley, located in the south coast of Sao Paulo State, Brazil, in 1975-1976. ROCV also causes fatal encephalitis in adult mice. Seroprevalence studies in humans, horses and water buffaloes in different regions of Brazil have suggested that ROCV is still circulating in the country, indicating the risk of re-emergence of this virus. West Nile virus (WNV) is also a mosquito-transmitted encephalitic flavivirus, however, WNV strains circulating in Australia have not been associated with outbreaks of disease in humans and exhibit low virulence in adult mice...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317853/terbium-ion-doping-in-ca3co4o9-a-step-towards-high-performance-thermoelectric-materials
#9
Shrikant Saini, Haritha Sree Yaddanapudi, Kun Tian, Yinong Yin, David Magginetti, Ashutosh Tiwari
The potential of thermoelectric materials to generate electricity from the waste heat can play a key role in achieving a global sustainable energy future. In order to proceed in this direction, it is essential to have thermoelectric materials that are environmentally friendly and exhibit high figure of merit, ZT. Oxide thermoelectric materials are considered ideal for such applications. High thermoelectric performance has been reported in single crystals of Ca3Co4O9. However, for large scale applications single crystals are not suitable and it is essential to develop high-performance polycrystalline thermoelectric materials...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317311/novel-pathogenic-variants-in-foxp3-in-fetuses-with-echogenic-bowel-and-skin-desquamation-identified-by-ultrasound
#10
Raymond J Louie, Queenie K-G Tan, Jennifer B Gilner, R Curtis Rogers, Noelle Younge, Stephanie B Wechsler, Marie T McDonald, Barbara Gordon, Christopher A Saski, Julie R Jones, Shelley J Chapman, Roger E Stevenson, John W Sleasman, Michael J Friez
Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome is a rare, X-linked recessive disease that affects regulatory T cells (Tregs) resulting in diarrhea, enteropathy, eczema, and insulin-dependent diabetes mellitus. IPEX syndrome is caused by pathogenic alterations in FOXP3 located at Xp11.23. FOXP3 encodes a transcription factor that interacts with several partners, including NFAT and NF-κB, and is necessary for the proper cellular differentiation of Tregs. Although variable, the vast majority of IPEX syndrome patients have onset of disease during infancy with severe enteropathy...
March 20, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28317268/enhanced-surface-charge-transport-and-stability-of-cds-1d-zr-fe2o3-nanorod-arrays-with-al2o3-passivation-layer-for-photoelectrochemical-solar-hydrogen-generation
#11
Jum Suk Jang, Mahadeo A Mahadik, Arunprabaharan Subramanian, Min Cho, Hee-Suk Chung
CdS sensitized 1D Zr:Fe2O3 nanorod arrays have been synthesized on fluorine-doped tin oxide substrates via a two-step hydrothermal method. The photoelectrochemical results demonstrate that the current density (4.2 mA.cm-2 at 0 V (vs. Ag/AgCl) recorded under illumination for the CdS/1D Zr:Fe2O3 photoanodes is 2.8 time higher than the bare 1D Zr:Fe2O3. The extended absorbance spectrum, the reduced recombination, and the effective transport of photogenerated holes in CdS to the electrolyte facilitate enhancement in photoelectrochemical performance...
March 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28317151/design-synthesis-and-evaluation-of-the-kinase-inhibition-potential-of-pyridylpyrimidinylaminophenyl-derivatives
#12
Priyanka Manchanda, Badri Parshad, Amit Kumar, Rakesh K Tiwari, Amir N Shirazi, Keykavous Parang, Sunil K Sharma
In view of potent kinase inhibitors for the treatment of myriad human disorders, we synthesized some structurally variant amide/cyclic amide derivatives based on pyridylpyrimidinylaminophenyl amine, the key pharmacophore of the kinase inhibitor drug molecule, imatinib, and evaluated their kinase inhibition potency. Among the various synthesized amides, compound 20, a cyclic amide/pyridin-2(1H)-one derivative, exhibited an IC50 value comparable to that of the drug imatinib against c-Src kinase, and another compound (14) containing a 2-((4-methyl-2-oxo-2H-chromen-6-yl)oxy)acetamide demonstrated an IC50 value of 8...
March 20, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28316174/-efficacy-and-safety-analysis-of-ivabradine-hydrochloride-treatment-of-chinese-patients-with-chronic-heart-failure-subgroup-analysis-of-chinese-patients-in-the-shift-study
#13
D Y Hu, D J Huang, Z Y Yuan, R P Zhao, X W Yan, M H Wang
Objective: To evaluate the efficacy and safety of ivabradine for the treatment of Chinese patients with chronic heart failure based on the Chinese subgroup data of the systolic heart failure treatment with the I(f) inhibitor ivabradine trial (SHIFT). Method: A total of 6 558 stable outpatients who presented symptoms of heart failure, with a left ventricular ejection fraction (LVEF) ≤35%, sinus rhythms with a heart rate ≥70 bpm participated in the randomized, double-blind, placebo-controlled, international multicenter clinical study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28315689/in-silico-prediction-of-hpxr-activators-using-structure-based-pharmacophore-modeling
#14
Nao Torimoto-Katori, Ruili Huang, Harutoshi Kato, Rikiya Ohashi, Menghang Xia
The activation of pregnane X receptor (PXR), a member of the nuclear receptor superfamily, can mediate potential drug-drug interactions by regulating the expression of several drug- mediated enzymes and transporters, resulting in reduced therapeutic efficacy or increased toxicity by producing reactive metabolites. Therefore, in the early stage of drug development, it is important to predict these risks using an in silico approach. We constructed a human PXR (hPXR) pharmacophore model based on known structural information of compounds that activate PXR...
March 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28315303/neuroprotective-effect-of-2-hydroxy-arachidonic-acid-in-a-rat-model-of-transient-middle-cerebral-artery-occlusion
#15
I F Ugidos, M Santos-Galdiano, D Pérez-Rodríguez, B Anuncibay-Soto, E Font-Belmonte, D J López, M Ibarguren, X Busquets, A Fernández López
Stroke modifies the composition of cell membranes by eliciting the breakdown of membrane phospholipids whose products, such as arachidonic acid (AA), are released in the cytosol. The action of enzymes such as cyclooxygenases on AA leads to inflammatory stimuli and increases the cell oxidative stress. We report here the neuroprotective effect of 2-hydroxyarachidonic acid (2OAA), a cyclooxygenase inhibitor derived from AA, as a promising neuroprotective therapy against stroke. The effect of a single dose of 2OAA, administered intragastrically 1 hour after the ischaemic insult, in a rat model of transient middle cerebral artery occlusion (tMCAO) was tested after 24 hours of reperfusion...
March 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28314697/demeanor-of-rivaroxaban-in-activated-inactivated-fxa
#16
Kaname Seki, Yosuke Mizuno, Toku Sakashita, Shintaro Nakano, Jun Tanno, Yasushi Okazaki, Toshihiro Muramatsu, Shigeyuki Nishimura, Takaaki Senbonmatsu
Activated factor X (FXa) plays an important role in thrombin generation and inflammation. Factor X is not converted constitutively to FXa, but only after intrinsic clotting factors are activated and/or cellular injury occurs. Although rivaroxaban is one of direct FXa inhibitors, its function in the inactivated coagulation cascade is unclear. In human umbilical vein endothelial cells that natively express protease-activated receptor-1 and -2, high dose rivaroxaban did not alter gene transcripts including pro-inflammatory genes in DNA microarray...
February 24, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28314192/one-pot-preparation-of-conductive-composite-containing-boronic-acid-derivative-for-non-enzymatic-glucose-detection
#17
Wen Wang, Liyan Kong, Jiaming Zhu, Liang Tan
The composite consisting of poly(azure A), gold nanoparticles and 4-mercaptophenylboronic acid (PAA-AuNPs-MPBA) was prepared on the glassy carbon electrode surface by using a one-pot electropolymerization protocol. The generation of poly(azure A) film, the reduction of HAuCl4 and the binding of MPBA on metallic gold were simultaneously achieved in the cyclic voltammetric scan process, which was verified by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy measurements...
March 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28306533/ros-mediated-induction-of-apoptosis-by-benzoquinone-embelin-in-human-colon-adenocarcinoma-cells-ht-29
#18
Kodandaram Sumalatha, Mohan Gowda, Sreepriya Meenakshisundaram
Background Embelin is a benzoquinone reported to possess anticancer activity in several in vivo and in vitro models of carcinogenesis, especially hematopoietic and prostate malignancy. A detailed investigation on the influence of embelin on epithelial malignancy model system, especially colon adenocarcinoma, is lacking. The objective of the current study is to investigate the antiproliferative, antiinvasive and proapoptotic potential of embelin on colon adenocarcinoma cell line HT-29. Methods The effect of embelin (35 µg/mL for 24 h) on cell proliferation was assessed by Sulforhodamine B assay and bromodeoxyuridine incorporation test, antiinvasive effect by Boyden chamber assay and scratch assay...
March 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28306309/thermal-fluctuations-of-ferroelectric-nanodomains-in-a-ferroelectric-dielectric-pbtio_-3-srtio_-3-superlattice
#19
Qingteng Zhang, Eric M Dufresne, Pice Chen, Joonkyu Park, Margaret P Cosgriff, Mohammed Yusuf, Yongqi Dong, Dillon D Fong, Hua Zhou, Zhonghou Cai, Ross J Harder, Sara J Callori, Matthew Dawber, Paul G Evans, Alec R Sandy
Ferroelectric-dielectric superlattices consisting of alternating layers of ferroelectric PbTiO_{3} and dielectric SrTiO_{3} exhibit a disordered striped nanodomain pattern, with characteristic length scales of 6 nm for the domain periodicity and 30 nm for the in-plane coherence of the domain pattern. Spatial disorder in the domain pattern gives rise to coherent hard x-ray scattering patterns exhibiting intensity speckles. We show here using variable-temperature Bragg-geometry x-ray photon correlation spectroscopy that x-ray scattering patterns from the disordered domains exhibit a continuous temporal decorrelation due to spontaneous domain fluctuations...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303893/changes-in-mirna-in-the-lung-and-whole-blood-after-whole-thorax-irradiation-in-rats
#20
Feng Gao, Pengyuan Liu, Jayashree Narayanan, Meiying Yang, Brian L Fish, Yong Liu, Mingyu Liang, Elizabeth R Jacobs, Meetha Medhora
We used a rat model of whole thorax x-ray irradiation to profile the microRNA (miRNA) in lung and blood up to 4 weeks after radiation. MiRNA from normal and irradiated Wistar rat lungs and whole blood were analyzed by next-generation sequencing and the changes by radiation were identified by differential deRNA-seq 1, 2, 3 and 4 weeks after irradiation. The average total reads/library was 2,703,137 with a mean of 88% mapping to the rat genome. Detailed profiles of 100 of the most abundant miRNA in rat blood and lung are described...
March 17, 2017: Scientific Reports
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