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Laura J Davidson, Charles J Davidson
Stroke leads to significant morbidity, disability, and mortality after TAVR. CKD and prior stroke are risk factors for stroke. Stratification of stroke risk would improve outcomes associated with TAVR. Ongoing prospective randomized trials on embolic protection and post implant anticoagulation are promising strategies to reduce stroke risk and new brain MRI lesions.
October 2016: Catheterization and Cardiovascular Interventions
Wen Zhou, John Thompson, Clifford Leznoff, Daniel Bernard Leznoff
The preparation and structural characterization of a series of chromium phthalocyanine complexes with multiple metal and ring oxidation states was achieved using PcCr(II) (1) (Pc = phthalocyanine) or PcCr(II)(THF)2 (1·THF2) as starting material. The reaction of soluble 1·THF2 with Br2 or I2 gave the PcCr(III) halide complexes PcCrX(THF) (X= I/I3, Br) (3, 4). Treatment of 1 with one-half equivalent of PhIO or air generated the dinuclear [PcCr(THF)]2(μ-O) (5), while the addition of one equivalent of AgSbF6 to 1 resulted in oxidation to THF-solvated octahedral [PcCr(III)(THF)2]SbF6 (6)...
October 17, 2016: Chemistry: a European Journal
Valmiki B Koli, Sagar D Delekar, Shivaji H Pawar
In this study, nanocomposites of Fe-doped TiO2 with multi-walled carbon nanotubes (0.1- 0.5 wt. %) were prepared by using sol-gel method. The structural and morphological analysis were carried out with using X-ray diffraction pattern and transmission electron microscopy, which confirm the presence of pure anatase phase and particle sizes in the range 15-20 nm. X-ray photoelectron spectroscopy was used to determine the surface compositions of the nanocomposites. UV-vis diffuse reflectance spectra confirm redshift in the optical absorption edge of nanocomposites with increasing amount of multi-walled carbon nanotubes...
December 2016: Journal of Materials Science. Materials in Medicine
X M Chen, F Q Li, S Yan, X C Wu, C L Tang
OBJECTIVE: To investigate the anti-inflammation effects by activation of the cholinergic anti-inflammatory pathway and its mechanisms in non-alcoholic steatohepatitis (NASH) model mice. METHODS: 6-week-old male C57BL/6J (B6) mice were randomly divided into four groups: the first group was normal mice, injected with saline; the second group was normal mice, injected with nicotine; the third group was NASH model mice, injected with saline; the fourth group was NASH model mice, injected with nicotine...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Madeleine Peschke, Clara Brieke, Max J Cryle
The glycopeptide antibiotics are peptide-based natural products with impressive antibiotic function that derives from their unique three-dimensional structure. Biosynthesis of the glycopeptide antibiotics centres of the combination of peptide synthesis, mediated by a non-ribosomal peptide synthetase, and the crosslinking of aromatic side chains of the peptide, mediated by the action of a cascade of Cytochrome P450s. Here, we report the first example of in vitro activity of OxyE, which catalyses the F-O-G ring formation reaction in teicoplanin biosynthesis...
October 18, 2016: Scientific Reports
Fumihiro Sanada, Yoshiaki Taniyama, Jun Muratsu, Rei Otsu, Masaaki Iwabayashi, Miguel Carracedo, Hiromi Rakugi, Ryuichi Morishita
Uncontrolled coagulation contributes to the pathophysiology of several chronic inflammatory diseases. In these conditions, senescent cells are often observed and is involved in the generation of inflammation. The coincidence of hyper-coagulation, cell senescence, and inflammation suggests the existence of a common underlying mechanism. Recent evidence indicates that activated coagulation factor X (FXa) plays a role in the processes beyond blood coagulation. This non-hematologic function entails the mediation of inflammation and tissue remodeling...
October 18, 2016: Scientific Reports
Nariyuki Saito, Nobuhisa Ishii, Teruto Kanai, Shuntaro Watanabe, Jiro Itatani
Long-wavelength lasers have great potential to become a new-generation drive laser for tabletop coherent light sources in the soft X-ray region. Because of the significantly low conversion efficiency from a long-wavelength light field to high-order harmonics, their pulse characterization has been carried out by measuring the carrier-envelope phase and/or spatial dependences of high harmonic spectra. However, these photon detection schemes, in general, have difficulty in obtaining information on the spectral phases, which is crucial to determine the temporal structures of high-order harmonics...
October 18, 2016: Scientific Reports
Sarah L Smith, Christopher Boothman, Heather A Williams, Beverly L Ellis, Joanna Wragg, Julia M West, Jonathan R Lloyd
Geological disposal of intermediate level radioactive waste in the UK is planned to involve the use of cementitious materials, facilitating the formation of an alkali-disturbed zone within the host rock. The biogeochemical processes that will occur in this environment, and the extent to which they will impact on radionuclide migration, are currently poorly understood. This study investigates the impact of biogeochemical processes on the mobility of the radionuclide technetium, in column experiments designed to be representative of aspects of the alkali-disturbed zone...
October 14, 2016: Science of the Total Environment
Young Jin Sa, Dong-Jun Seo, Jinwoo Woo, Jung Tae Lim, Jae Yeong Cheon, Seung Yong Yang, Jae Myeong Lee, Dongwoo Kang, Tae Joo Shin, Hyeon Suk Shin, Hu Young Jeong, Chul Sung Kim, Min Gyu Kim, Tae-Young Kim, Sang Hoon Joo
Iron-nitrogen on carbon (Fe-N/C) catalysts have emerged as promising non-precious metal catalysts (NPMCs) for oxygen reduction reaction (ORR) in energy conversion and storage devices. It has been widely suggested that an active site structure for Fe-N/C catalysts contains Fe-Nx coordination. However, the preparation of high-performance Fe-N/C catalysts mostly involves a high-temperature pyrolysis step, which generates not only catalytically active Fe-Nx sites, but also less active large iron-based particles...
October 18, 2016: Journal of the American Chemical Society
Jingzi Zhong, Tiantian Xu, Gang Chen, Haixia Liao, Jiapeng Zhang, Dan Lan
Introduction Duchenne and Becker muscular dystrophies (DMD and BMD) are X-linked myopathies caused by mutations of the dystrophin gene. Methods Multiplex ligation-dependent probe amplification (MLPA) combined with next-generation sequencing (NGS) of the exons of the dystrophin gene were performed in 92 suspected DMD/BMD patients. Patients with negative results were subjected to additional muscle diseases panel tests. Results DNA rearrangements were detected in 65(70.65%) patients using MLPA. The deletions primarily clustered at exons 45-55, followed by exons 2-19...
October 17, 2016: Muscle & Nerve
Michael Dale Anderson, Brad Aitchison, David C Johnson
Atomic layer deposition (ALD) was used to prepare amorphous thin films of Al2O3, Nb2O5, and Ta2O5 on both silicon substrates and aluminum blocks. Etch rates in 10M NH4OH were determined from X-ray reflectometry data collected as a function of time. Amorphous Al2O3 thin films were found to have an etch rate of 0.5 nm min-1 and an increase in roughness of ~ 0.01 nm min-1. Electron microscopy data showed etch pits, consistent with the increase in roughness. Amorphous Nb2O5 and Ta2O5 films showed no appreciable etching or roughening over the course of a ~ 500 hour continuous immersion...
October 17, 2016: ACS Applied Materials & Interfaces
John Lee
The molecular mechanisms of the bioluminescence systems of the firefly, bacteria, and those utilizing imidazopyrazinone luciferins such as coelenterazine, are gradually being uncovered using modern biophysical methods such as dynamic (ns-ps) fluorescence spectroscopy, NMR, X-ray crystallography, and computational chemistry. The chemical structures of all reactants are well defined and the spatial structures of the luciferases are providing important insight into interactions within the active cavity. It is generally accepted that the firefly and coelenterazine systems, although proceeding by different chemistries, both generate a dioxetanone high energy species that undergoes decarboxylation to form directly the product in its S1 state, the bioluminescence emitter...
October 17, 2016: Photochemistry and Photobiology
Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chun
After carefully checking the original data of ROS generation experiment, we found that in Fig. 3E the x-axis was incorrently labeled. ISL should be substituted with CA. The corrected version of Fig. 3E is shown below. We apologize for the error and appreciate the opportunity to correct the scientific record. All authors agree with this correction. [the original article was published in the Oncology Reports 35: 2723-2732, 2016; DOI: 10.3892/or.2016.4642].
September 29, 2016: Oncology Reports
Ai-Shun Guo, Yi-Qun Huang, Xu-Dong Ma, Rui-Sheng Lin
The present study aimed to investigate the differential expression and clinical significance of histone methyltransferase G9a, histone H3K9me2 and histone H3K9me1 in human brain glioma and adjacent tissue samples. It also aimed to observe the effect and mechanism of BIX‑01294, as an inhibitor of methyltransferase G9a, on the proliferation, apoptosis, methylation of H3K9 and H3K27, and the acetylation in U251 glioma cells in vitro. The differential expression of methyltransferase G9a, histone H3K9me2 and histone H3K9me1 in in human brain glioma and adjacent tissues were analyzed by immunohistochemistry, a growth curve of U251 cells following treatment with BIX‑01294 was determined using the MTT assay...
October 6, 2016: Molecular Medicine Reports
Vincent Rampazzi, Julien Roger, Régine Amardeil, Marie-José Penouilh, Philippe Richard, Paul Fleurat-Lessard, Jean-Cyrille Hierso
A smart steric control of the metallocene backbone in bis- and poly(phosphino)ferrocene ligands favors intramolecular aurophilic interactions between [AuCl] fragments in polynuclear gold(I) complexes. We synthesized and characterized by multinuclear NMR and X-ray diffraction analysis mono-, di-, and polynuclear gold complexes of constrained ferrocenyl diphosphines, which bear either bulky tert-butyl groups or more flexible siloxane substituents at the cyclopentadienyl rings. The complexes meso-1,1'-bis(diphenylphosphino)-3,3'-di-tert-butylferrocene (4-m), rac-1,1'-bis[bis(5-methyl-2-furyl)phosphino]-3,3'-di-tert-butylferrocene (5-r), and rac-1,1'-bis(diphenylphosphino)-3,3'-bis[(tri-iso-propylsilyl)oxy]ferrocene (6-r) were used to form dinuclear gold complexes...
October 17, 2016: Inorganic Chemistry
R J Cassidy, X Yang, T Liu, M Thomas, S G Nour, A B Jani
PURPOSE: Sexual dysfunction after radiotherapy for prostate cancer remains an important late adverse toxicity. The neurovascular bundles (NVB) that lie posterolaterally to the prostate are typically spared during prostatectomy, but in traditional radiotherapy planning they are not contoured as an organ-at-risk with dose constraints. Our goal was to determine the dosimetric feasibility of "NVB-sparing" prostate radiotherapy while still delivering adequate dose to the prostate. METHODS: Twenty-five consecutive patients with prostate cancer (with no extraprostatic disease on pelvic magnetic resonance imaging [MRI]) who that were treated with external beam radiotherapy, with the same primary planning target volume margins, to a dose of 79...
October 13, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Kerstin Mueller, Rebecca Fahrig, Michael Manhart, Yu Deuerling-Zheng, Jarrett Rosenberg, Teri Moore, Arundhuti Ganguly, Nishita Kothary
RATIONALE AND OBJECTIVES: Intra-procedural measurement of hepatic perfusion following liver embolization continues to be a challenge. Blood volume imaging before and after interventional procedures would allow identifying the treatment end point or even allow predicting treatment outcome. Recent liver oncology studies showed the feasibility of parenchymal blood volume (PBV) imaging using an angiographic C-arm system. This study was done to evaluate the reproducibility of PBV measurements using cone beam computed tomography (CBCT) before and after embolization of the liver in a swine model...
October 10, 2016: Academic Radiology
Dong Jin Lee, G Mohan Kumar, P Ilanchezhiyan, Jae-Chul Lee, Sung Ryong Ryu, Tae Won Kang
Nowadays, solid-state inorganic-organic hybrid solar cells based on one-dimensional (1D) inorganic semiconducting nanostructures and organic polymers are believed to offer convincing solutions for the realm of next generation solar cells. In this regard, 1D ZnCdS nanowire (NW) arrays were fabricated on transparent conducting substrates through a catalyst free co-evaporation method and their wurtzite structural characteristics, 1D morphological layout and valence state/composition were studied in detail using X-ray diffraction, high-resolution electron microscopy and X-ray photoelectron spectroscopy, respectively...
October 5, 2016: Journal of Colloid and Interface Science
M X Rodrigues, S F Lima, C H Higgins, S G Canniatti-Brazaca, R C Bicalho
The bacterium Lactococcus lactis is widely used in food production and in medical applications, and is considered safe for human and animal use. However, studies have also linked Lactococcus bacteria to infection. For example, certain variants of Lactococcus species have been associated with bovine mastitis (e.g., Lactococcus lactis and Lactococcus garvieae). In this study, we investigated an outbreak of bovine mastitis thought to be associated with Lactococcus bacteria by using microbiological and molecular techniques...
October 13, 2016: Journal of Dairy Science
David Baca-Carrasco, Jorge X Velasco-Hernández
Since the first major outbreak reported on the island Yap in 2007, the Zika virus spread has alerted the scientific community worldwide. Zika is an arbovirus transmitted by Aedes mosquitoes; particularly in Central and South America, the main vector is the same mosquito that transmits dengue and chikungunya, Aedes aegypti. Seeking to understand the dynamics of spread of the Zika, in this paper, three mathematical models are presented, in which vector transmission of the virus, sexual contact transmission and migration are considered...
October 14, 2016: Bulletin of Mathematical Biology
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