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Nuclear medicine, cancer, oncology

Markus Luster, Andreas Pfestroff, Frederik A Verburg
PURPOSE OF REVIEW: The purpose is to review recent advances concerning the role of nuclear medicine in endocrine oncology. RECENT FINDINGS: For I therapy of thyroid cancer a thyrotropin (TSH) more than 30 mU/l has for many years been deemed a condition sine qua non. However, new data show that patients with lower TSH levels at the time of ablation have the same rate of successful ablation as those with TSH more than 30 mU/l.I-124 combined integrated positron emission tomography and computed X-ray tomography was shown to be highly accurate in predicting findings on posttherapy radioiodine scanning and was shown to have a high prognostic power...
January 2017: Current Opinion in Oncology
Michael S Hofman, Rodney J Hicks
(18)F-fluorodeoxyglucose (FDG) PET/CT is a pivotal imaging modality for cancer imaging, assisting diagnosis, staging of patients with newly diagnosed malignancy, restaging following therapy and surveillance. Interpretation requires integration of the metabolic and anatomic findings provided by the PET and CT components which transcend the knowledge base isolated in the worlds of nuclear medicine and radiology, respectively. In the manuscript we detail our approach to reviewing and reporting a PET/CT study using the most commonly used radiotracer, FDG...
October 18, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Anish Khalil, Muhammad Faheem, Ammad Fahim, Haran Innocent, Zainab Mansoor, Shehrbano Rizvi, Hizra Farrukh
Background. The biomedical care for cancer has not been complemented by psychosocial progressions in cancer care. Objectives. To find the prevalence of anxiety and depression amongst cancer patients in a hospital setting. Design and Setting. This cross-sectional study was conducted at the tertiary care hospitals Shifa International Hospital Islamabad and Nuclear Medicine, Oncology, and Radiotherapy Institute [NORI]. Patients and Methods. 300 patients were interviewed from both the outpatient and inpatient department using The Aga Khan University Anxiety and Depression Scale (AKUADS)...
2016: Psychiatry Journal
Steven P Rowe, Alexander Drzezga, Bernd Neumaier, Markus Dietlein, Michael A Gorin, Michael R Zalutsky, Martin G Pomper
Radiohalogenated agents are often the first line of pursuit in the development of new radiopharmaceuticals-whether antibodies, peptides, or small molecules-because of their ease of synthesis, lack of substantial steric perturbation of the original affinity agent (in some cases, providing enhanced affinity), and capacity to be transformed into therapeutics (in some cases, with a mere switch of an isotope). They often provide proof of a principle before optimization for pharmacokinetics or generation of radiometallated agents, when the latter are necessary...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Clasina M Venema, Giulia Apollonio, Geke A P Hospers, Carolina P Schröder, Rudi A J O Dierckx, Erik F J de Vries, Andor W J M Glaudemans
The estrogen derivative 16α-F-fluoro-17β-estradiol (FES) is a PET tracer that has been used in a variety of preclinical and clinical studies to detect estrogen receptor (ER) expression, mainly in breast cancer, but also for other oncological indications. As a result of the success of these studies and the potential applications of the tracer, FES starts to be implemented in routine clinical practice. However, the number of centers using this tracer is still limited and many nuclear medicine physicians and medical oncologists are still unaware of the possibilities FES PET imaging offers...
November 2016: Clinical Nuclear Medicine
Anna Gasinska
Marie Sklodowska-Curie, an extraordinary woman, a Polish scientist who lived and worked in France, led to the development of nuclear energy and the treatment of cancer. She was the laureate of two Nobel Prizes, the first woman in Europe who obtained the degree of Doctor of Science and opened the way for women to enter fields which had been previously reserved for men only. As a result of her determination and her love of freedom, she has become an icon for many female scientists active in radiation sciences...
May 2016: Reports of Practical Oncology and Radiotherapy
Leonardo G Ferreira, Glaucius Oliva, Adriano D Andricopulo
INTRODUCTION: Pocket-based drug design has contributed to major scientific breakthroughs in pharmaceutical research and development (R&D). The integrated use of experimental and computational methods, primarily during the early phases of drug discovery, has enabled the development of highly potent and selective small-molecule ligands. In this scenario, the targeting of protein-protein interactions (PPIs) has emerged as an attractive strategy for designing innovative drugs for highly complex diseases, such as cancer...
October 2016: Expert Opinion on Drug Discovery
Yoshiharu Ohno, Hisanobu Koyama, Ho Yun Lee, Sachiko Miura, Takeshi Yoshikawa, Kazuro Sugimura
Assessment of regional pulmonary perfusion as well as nodule and tumor perfusions in various pulmonary diseases are currently performed by means of nuclear medicine studies requiring radioactive macroaggregates, dual-energy computed tomography (CT), and dynamic first-pass contrast-enhanced perfusion CT techniques and unenhanced and dynamic first-pass contrast enhanced perfusion magnetic resonance imaging (MRI), as well as time-resolved three-dimensional or four-dimensional contrast-enhanced magnetic resonance angiography (MRA)...
September 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Samanta Taurone, Filippo Galli, Alberto Signore, Enzo Agostinelli, Rudi A J O Dierckx, Antonio Minni, Marcella Pucci, Marco Artico
Following the publication of this article, after having re-examined our manuscript, we noted an error in the acknowledgements section, as regards the funding of our study. The correct version of acknowledgements section is shown below: Acknowledgements This study was supported by the Ministry of Health and Fondazione Roma and by NOBILE S.p.A. Thanks are also due to REGIONE LAZIO Prot. FILAS-RU-2014 - 1020 (E.A.). [the original article was published in the International Journal of Oncology 49: 437-447, 2016; DOI: 10...
October 2016: International Journal of Oncology
Ulf Lützen, Carsten Maik Naumann, Jens Dischinger, Marlies Marx, René Baumann, Yi Zhao, Michael Jüptner, Daniar Osmonov, Katrin Bothe, Klaus-Peter Jünemann, Maaz Zuhayra
BACKGROUND: The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB) for lymph node staging in penile cancer with non-palpable inguinal lymph nodes as one diagnostic method. Despite this, the method is neither widely nor regularly applied in Germany - the same applies to many other countries, which may be due to insecurity in dealing with open radioactive tracers...
2016: BMC Urology
Ahmed Essmat Shouman, Nahla Fawzy Abou El Ezz, Nivine Gado, Amal Mahmoud Ibrahim Goda
Purpose - The purpose of this paper is to measure health-related quality of life (QOL) among patients with early stage cancer breast under curative treatment at department of oncology and nuclear medicine at Ain Shams University Hospitals. Identify factors affecting QOL among these patients. Design/methodology/approach - A cross-sectional study measured QOL among early stage female breast cancer (BC) patients and determined the main factors affecting their QOL. Three interviewer administered questionnaires were used...
August 8, 2016: International Journal of Health Care Quality Assurance
Yi-Chao Zheng, Jin-Lian Ma, Ying Liu, Hong M Liu
Histone lysine methylation can be modified by various writers and erasers. Different from other epigenetic modifications, mono-, di, and tri- methylation distinctly modulate chromatin structure and thereby contribute to the regulation of DNA-based nuclear processes such as transcription, replication and repair on their target genes depending on different sites. Modulators with opposing catalytic activities dynamically and precisely control levels of histone lysine methylation, and individual enzymes within these families have become candidate oncology targets in recent years...
July 15, 2016: Current Pharmaceutical Design
Carla Abreu, Ana Grilo, Filipa Lucena, Elisabete Carolino
The purpose of this study was to investigate the subjective perception of anxiety pre- and post-procedure, and explore the relationship between demographic, clinical variables and cancer patients' anxiety during a positron emission tomography/computed tomography (PET/CT) scan. Two hundred and thirty-two oncological out patients, with clinical indication for performing an (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT scan and attending a nuclear medicine (NM) department, participated in the study. Patients' anxiety and subjective experience of PET/CT were examined using two self-report questionnaires...
July 2, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Pınar Özgen Kiratli, Murat Tuncel, Zvi Bar-Sever
Nuclear medicine has an important role in the management of many cancers in pediatric age group with multiple imaging modalities and radiopharmaceuticals targeting various biological uptake mechanisms. 18-Flourodeoxyglucose is the radiotracer of choice especially in patients with sarcoma and lymphoma. (18)FDG-PET, for sarcoma and lymphomas, is proved to be superior to conventional imaging in staging and therapy response. Although studies are limited in pediatric population, (18)FDG-PET/CT has found its way through international guidelines...
July 2016: Seminars in Nuclear Medicine
Hina Hashmi, Amir Maqbool, Saeed Ahmed, Adeel Ahmed, Kulsoom Sheikh, Akhtar Ahmed
OBJECTIVE: To evaluate the efficacy of cisplatin-based concurrent chemoradiation in squamous cell carcinoma of cervix and the frequency of acute toxicity. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Department of Clinical Oncology, Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN), Karachi, from September 2010 to September 2011. METHODOLOGY: Eighty patients with histologically proven squamous cell carcinoma of cervix were included...
April 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Andrew B Rosenkrantz, Abimbola Ayoola
RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the trends in the impact factor (IF) of radiological journals over a recent 12-year period, including associations between IF and journal topic. MATERIALS AND METHODS: Journal Citation Reports (JCR) was used to identify all biomedical journals and all radiological journals (assigned a JCR category of "Radiology, Nuclear Medicine, & Medical Imaging"), along with journal IF, in 2003 and 2014. Radiological journals were manually classified by topic...
June 2016: Academic Radiology
Muhammad Mansha, Maryam Saleem, Muhammad Wasim, Muhammad Tariq
BACKGROUND: Breast cancer is the most prevalent cancer in women worldwide and its frequency is increasing gradually in many countries. Over the last three decades an increase in the breast cancer has been witnessed in the earlier low-risk Asian countries including Pakistan. PURPOSE: The objective of the current study was to assess the prevalence of known risk factors like early menarche, late menopause, socio economic, reproductive and demographic factors, among women diagnosed with breast cancer at INMOL hospital, Lahore, Punjab, as little information exists in this regard...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Barbara Jarząb, Marek Dedecjus, Daria Handkiewicz-Junak, Dariusz Lange, Andrzej Lewiński, Anna Nasierowska-Guttmejer, Marek Ruchała, Dorota Słowińska-Klencka, Janusz Nauman, Zbigniew Adamczewski, Maciej Bagłaj, Agata Bałdys-Waligórska, Marcin Barczyński, Tomasz Bednarczuk, Andrzej Cichocki, Agnieszka Czarniecka, Rafał Czepczyński, Aneta Gawlik, Alicja Hubalewska-Dydejczyk, Krystian Jażdżewski, Grzegorz Kamiński, Małgorzata Karbownik-Lewińska, Beata Kos-Kudła, Andrzej Kułakowski, Krzysztof Kuzdak, Katarzyna Łącka, Ewa Małecka-Tendera, Marek Niedziela, Lech Pomorski, Stanisław Sporny, Zoran Stojcev, Anhelli Syrenicz, Jan Włoch, Jolanta Krajewska, Sylwia Szpak-Ulczok, Michal Kalemba, Monika Buziak-Bereza
Revised Guidelines of Polish National Societies Prepared on the initiative of the Polish Group for Endocrine Tumours approved in their final version between November 16th and 28th, 2015 by the Scientific Committee of the V Conference "Thyroid Cancer and other malignancies of endocrine glands" organised between November 14th and 17th, 2015 in Wisla, Poland; called by the following Societies: Polish Endocrine Society, Polish Society of Oncology, Polish Thyroid Association, Polish Society of Pathologists, Society of Polish Surgeons, Polish Society of Surgical Oncology, Polish Society of Clinical Oncology, Polish Society of Radiation Oncology, Polish Society of Nuclear Medicine, Polish Society of Paediatric Endocrinology, Polish Society of Paediatric Surgeons, Polish Society of Ultrasonography Gliwice-Wisła, 2015 DECLARATION: These recommendations are created by the group of delegates of the National Societies, which declare their willingness to participate in the preparation of the revised version of the Polish Guidelines...
2016: Endokrynologia Polska
Laura Evangelista, Alberto Briganti, Stefano Fanti, Stephen Joniau, Sven Reske, Riccardo Schiavina, Christian Stief, George N Thalmann, Maria Picchio
CONTEXT: Radiolabelled choline positron emission tomography has changed the management of prostate cancer patients. However, new emerging radiopharmaceutical agents, like radiolabelled prostate specific membrane antigen, and new promising hybrid imaging will begin new challenges in the diagnostic field. OBJECTIVE: The continuous evolution in nuclear medicine has led to the improvement in the detection of recurrent prostate cancer (PCa), particularly distant metastases...
July 2016: European Urology
Mike Sathekge, James M Warwick, Alex Doruyter, Mariza Vorster
Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed tomography (PET/CT). PET is a non-invasive tool that provides tomographic images and quantitative parameters of perfusion, cell viability, and proliferation and/or metabolic activity of tissues. Fusion of the functional information with the morphological detail provided by CT as PET/CT can provide clinicians with a sensitive and accurate one-step whole-body diagnostic and prognostic tool, which directs and changes patient management...
November 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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