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https://www.readbyqxmd.com/read/29192364/liver-metastases-from-prostate-cancer-at-11c-choline-pet-ct-a-multicenter-retrospective-analysis
#1
Pietro Ghedini, I Bossert, L Zanoni, F Ceci, T Graziani, P Castellucci, V Ambrosini, F Massari, E Nobili, B Melotti, A Musto, S Zoboli, L Antunovic, M Kirienko, A Chiti, C Mosconi, A Ardizzoni, R Golfieri, S Fanti, C Nanni
AIM: During our daily clinical practice using 11C-Choline PET/CT for restaging patients affected by relapsing prostate cancer (rPCa) we noticed an unusual but significant occurrence of hypodense hepatic lesions with a different tracer uptake. Thus, we decided to evaluate the possible correlation between rPCa and these lesions as possible hepatic metastases. MATERIALS AND METHODS: We retrospectively enrolled 542 patients diagnosed with rPCa in biochemical relapse after a radical treatment (surgery and/or radiotherapy)...
November 30, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29170516/metabolic-differences-in-glutamine-utilization-lead-to-metabolic-vulnerabilities-in-prostate-cancer
#2
Niki Marie Zacharias, Christopher McCullough, Sriram Shanmugavelandy, Jaehyuk Lee, Youngbok Lee, Prasanta Dutta, James McHenry, Linda Nguyen, William Norton, Lawrence W Jones, Pratip K Bhattacharya
The new oncologic paradigm of precision medicine is focused on identifying metabolic, proteomic, transcriptomic and genomic variabilities in tumors that can be exploited to tailor treatments and improve patient outcomes. Metabolic changes are a hallmark of cancer, and inhibition of metabolic pathways is now a major strategy in medicinal chemistry for targeting cancers. However, non-invasive biomarkers to categorize metabolic subtypes are in short supply. The purpose of this study was to characterize the intracellular and extracellular metabolic profiles of four prostate cancer cell lines with varying degrees of aggressiveness...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#3
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29123013/-68-ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#4
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography ((68)Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with (68)Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover (68)Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of (68)Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29097926/advanced-functional-tumor-imaging-and-precision-nuclear-medicine-enabled-by-digital-pet-technologies
#5
REVIEW
Chadwick L Wright, Katherine Binzel, Jun Zhang, Michael V Knopp
The purpose of this article is to provide a brief overview of the background, basic principles, technological evolution, clinical capabilities, and future directions for functional tumor imaging as PET evolves from the conventional photomultiplier tube-based platform into a fully digital detector acquisition platform. The recent introduction of solid-state digital photon counting PET detector is the latest evolution of clinical PET which enables faster time-of-flight timing resolution that leads to more precise localization of the annihilation events and further contributes to reduction in partial volume and thus makes high definition and ultrahigh definition PET imaging feasible with current standard acquisition procedures...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29075832/-68-ga-psma-11-ligand-pet-imaging-in-patients-with-biochemical-recurrence-after-radical-prostatectomy-diagnostic-performance-and-impact-on-therapeutic-decision-making
#6
B Grubmüller, P Baltzer, D D'Andrea, S Korn, A R Haug, M Hacker, K H Grubmüller, G M Goldner, W Wadsak, S Pfaff, J Babich, C Seitz, H Fajkovic, M Susani, P Mazal, G Kramer, S F Shariat, Markus Hartenbach
OBJECTIVE: To evaluate the diagnostic performance of [(68)Ga]Ga-PSMA(HBED-CC) conjugate 11 positron emission tomography (PSMA-PET) in the early detection of metastases in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) for clinically non-metastatic prostate cancer, to compare it to CT/MRI alone and to assess its impact on further therapeutic decisions. MATERIAL AND METHODS: We retrospectively assessed 117 consecutive hormone-naïve BCR patients who had (68)Ga-PSMA 11 PET/CT (n = 46) or PET/MRI (n = 71) between May 2014 and January 2017...
October 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#7
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025377/18f-fdg-pet-ct-in-breast-cancer-evidence-based-recommendations-in-initial-staging
#8
REVIEW
Ana Paula Caresia Aroztegui, Ana María García Vicente, Soledad Alvarez Ruiz, Roberto Carlos Delgado Bolton, Javier Orcajo Rincon, Jose Ramon Garcia Garzon, Maria de Arcocha Torres, Maria Jose Garcia-Velloso
Current guidelines do not systematically recommend 18F-FDG PET/CT for breast cancer staging; and the recommendations and level of evidence supporting its use in different groups of patients vary among guidelines. This review summarizes the evidence about the role of 18F-FDG PET/CT in breast cancer staging and the therapeutic and prognostic impact accumulated in the last decade. Other related aspects, such as the association of metabolic information with biology and prognosis are considered and evidence-based recommendations for the use of 18F-FDG PET/CT in breast cancer staging are offered...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28941866/-68-ga-psma-pet-ct-in-prostate-cancer
#9
J R García Garzón, M de Arcocha Torres, R Delgado-Bolton, F Ceci, S Alvarez Ruiz, J Orcajo Rincón, A P Caresia Aróztegui, M J García Velloso, A M García Vicente
Positron emission tomography/computed tomography (PET/CT) with (68)Ga-PSMA is a non-invasive diagnostic technique to image prostate cancer with increased prostate-specific membrane antigen (PSMA) expression. PSMA is a transmembrane protein present in all prostatic tissues. Increased PSMA expression is seen in several malignancies, although prostate cancer is the tumour where it presents higher concentrations. Almost all prostate adenocarcinomas show PSMA expression in most of lesions, primary and metastatic...
September 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28864620/individualized-dosimetry-for-theranostics-necessary-nice-to-have-or-counterproductive
#10
REVIEW
Uta Eberlein, Marta Cremonesi, Michael Lassmann
In 2005, the term theragnostics (theranostics) was introduced for describing the use of imaging for therapy planning in radiation oncology. In nuclear medicine, this expression describes the use of tracers for predicting the absorbed doses in molecular radiotherapy and, thus, the safety and efficacy of a treatment. At present, the most successful groups of isotopes for this purpose are (123)I/(124)I/(131)I, (68)Ga/(177)Lu, and (111)In/(86)Y/(90)Y. The purpose of this review is to summarize available data on the dosimetry and dose-response relationships of several theranostic compounds, with a special focus on radioiodine therapy for differentiated thyroid cancer and peptide receptor radionuclide therapy...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28864612/clinical-history-of-the-theranostic-radionuclide-approach-to-neuroendocrine-tumors-and-other-types-of-cancer-historical-review-based-on-an-interview-of-eric-p-krenning-by-rachel-levine
#11
Rachel Levine, Eric P Krenning
In nuclear medicine, the term theranostics describes the combination of therapy and diagnostic imaging. In practice, this concept dates back more than 50 years; however, among the most successful examples of theranostics are peptide receptor scintigraphy and peptide receptor radionuclide therapy of neuroendocrine tumors. The development of these modalities through the radiolabeling of somatostatin analogs with various radionuclides has led to a revolution in patient management and established a foundation for expansion of the theranostic principle into other oncology indications...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28750749/incidental-focal-colonic-uptake-in-studies-18-f-fdg-pet-ct
#12
L Servente, V Gigirey, M García Fontes, O Alonso
OBJECTIVES: To assess the frequency of focal colonic uptake as an incidental observation in (18)F-FDG PET/CT studies, and to correlate this finding with histopathological results. MATERIAL AND METHODS: Out of a total of 3,176 PET/CT studies with (18)F-FDG systematic analysis was carried out on 30 studies in which colonic focal uptake was observed. Patients with known colorectal neoplasia were excluded. The maximum standardised uptake values (SUVm) and the morphological findings provided by the CT were recorded...
July 24, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#13
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28690675/development-of-sentinel-node-biopsy-roll-and-iart-in-early-breast-cancer-at-the-european-institute-of-oncology-milan-ieo
#14
REVIEW
Giovanni Paganelli
The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689522/efficacy-and-toxicity-of-concurrent-chemoradiation-in-inoperable-oral-carcinoma-in-pakistani-population
#15
Abdul Rehman, Zafar Allaudin, Hasan Nisar, Irfan Ullah Khan, Ismat Fatima, Amira Shami, Misbah Masood, Abubaker Shahid
OBJECTIVE: To evaluate the efficacy of concurrent chemoradiation in patients with locally advanced inoperable squamous cell carcinoma of oral cavity in terms of local control and toxicity. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2008 to December 2013. METHODOLOGY: Sixty-nine patients with locally advanced inoperable oral cavity cancer, registered in INMOL hospital from January 2008 to December 2013 who fulfilled a pre-defined eligibility criteria, were enrolled in the study...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28624849/the-accuracy-of-68-ga-psma-pet-ct-in-primary-lymph-node-staging-in-high-risk-prostate-cancer
#16
Can Öbek, Tünkut Doğanca, Emre Demirci, Meltem Ocak, Ali Rıza Kural, Asıf Yıldırım, Uğur Yücetaş, Çetin Demirdağ, Sarper M Erdoğan, Levent Kabasakal
PURPOSE: To assess the diagnostic accuracy of (68)Ga-PSMA PET in predicting lymph node (LN) metastases in primary N staging in high-risk and very high-risk nonmetastatic prostate cancer in comparison with morphological imaging. METHODS: This was a multicentre trial of the Society of Urologic Oncology in Turkey in conjunction with the Nuclear Medicine Department of Cerrahpasa School of Medicine, Istanbul University. Patients were accrued from eight centres. Patients with high-risk and very high-risk disease scheduled to undergo surgical treatment with extended LN dissection between July 2014 and October 2015 were included...
June 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#17
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28550611/-18-f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-malignancy-in-patients-with-paraneoplastic-neurological-syndrome-a-systematic-review-and-meta-analysis
#18
REVIEW
Ana María García Vicente, Roberto C Delgado-Bolton, Mariano Amo-Salas, Jesús López-Fidalgo, Ana Paula Caresia Aróztegui, José Ramón García Garzón, Javier Orcajo Rincón, María José García Velloso, María de Arcocha Torres, Soledad Alvárez Ruíz
PURPOSE: The detection of occult cancer in patients suspected of having a paraneoplastic neurological syndrome (PNS) poses a diagnostic challenge. The aim of our study was to perform a systematic review and meta-analysis to assess the diagnostic performance of FDG PET for the detection of occult malignant disease responsible for PNS. METHODS: A systematic review of the literature (MEDLINE, EMBASE, Cochrane, and DARE) was undertaken to identify studies published in any language...
August 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28541775/cellular-response-to-exponentially-increasing-and-decreasing-dose-rates-implications-for-treatment-planning-in-targeted-radionuclide-therapy
#19
Jay H Solanki, Thomas Tritt, Jordan B Pasternack, Julia J Kim, Calvin N Leung, Jason D Domogauer, Nicholas W Colangelo, Venkat R Narra, Roger W Howell
The treatment of cancer using targeted radionuclide therapy is of interest to nuclear medicine and radiation oncology because of its potential for killing tumor cells while minimizing dose-limiting toxicities to normal tissue. The ionizing radiations emitted by radiopharmaceuticals deliver radiation absorbed doses over protracted periods of time with continuously varying dose rates. As targeted radionuclide therapy becomes a more prominent part of cancer therapy, accurate models for estimating the biologically effective dose (BED) or equieffective dose (EQD2α/β) will become essential for treatment planning...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28476712/prevalence-and-diagnostic-of-head-and-neck-cancer-in-pakistan
#20
Azeem Akhtar, Ijaz Hussain, Muhammad Talha, Muhammad Shakeel, Muhammad Faisal, Muhammad Ameen, Tajammal Hussain
Head and Neck (HN) cancer is the most frequently identified cancer across the globe and is considered as 8-10 % of all cancers in Southeast Asia. The social and cultural habits are the main cause of the remarkable increase in HN cancer in Pakistan. HN cancers are more prevalent in men as compared to women. The HN cancer in Pakistan is mainly attributed to discrete demographic profile, risk elements, eating patterns and family history. The foremost factors of risk are linked with cigarette smoking, alcoholic drinks and tobacco chewing like paan, gutka, etc...
September 2016: Pakistan Journal of Pharmaceutical Sciences
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