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Nuclear medicine, cancer, oncology

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https://www.readbyqxmd.com/read/28750749/incidental-focal-colonic-uptake-in-studies-18-f-fdg-pet-ct
#1
L Servente, V Gigirey, M García Fontes, O Alonso
OBJECTIVES: To assess the frequency of focal colonic uptake as an incidental observation in (18)F-FDG PET/CT studies, and to correlate this finding with histopathological results. MATERIAL AND METHODS: Out of a total of 3,176 PET/CT studies with (18)F-FDG systematic analysis was carried out on 30 studies in which colonic focal uptake was observed. Patients with known colorectal neoplasia were excluded. The maximum standardised uptake values (SUVm) and the morphological findings provided by the CT were recorded...
July 24, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#2
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28690675/development-of-sentinel-node-biopsy-roll-and-iart-in-early-breast-cancer-at-the-european-institute-of-oncology-milan-ieo
#3
REVIEW
Giovanni Paganelli
The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689522/efficacy-and-toxicity-of-concurrent-chemoradiation-in-inoperable-oral-carcinoma-in-pakistani-population
#4
Abdul Rehman, Zafar Allaudin, Hasan Nisar, Irfan Ullah Khan, Ismat Fatima, Amira Shami, Misbah Masood, Abubaker Shahid
OBJECTIVE: To evaluate the efficacy of concurrent chemoradiation in patients with locally advanced inoperable squamous cell carcinoma of oral cavity in terms of local control and toxicity. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2008 to December 2013. METHODOLOGY: Sixty-nine patients with locally advanced inoperable oral cavity cancer, registered in INMOL hospital from January 2008 to December 2013 who fulfilled a pre-defined eligibility criteria, were enrolled in the study...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28624849/the-accuracy-of-68-ga-psma-pet-ct-in-primary-lymph-node-staging-in-high-risk-prostate-cancer
#5
Can Öbek, Tünkut Doğanca, Emre Demirci, Meltem Ocak, Ali Rıza Kural, Asıf Yıldırım, Uğur Yücetaş, Çetin Demirdağ, Sarper M Erdoğan, Levent Kabasakal
PURPOSE: To assess the diagnostic accuracy of (68)Ga-PSMA PET in predicting lymph node (LN) metastases in primary N staging in high-risk and very high-risk nonmetastatic prostate cancer in comparison with morphological imaging. METHODS: This was a multicentre trial of the Society of Urologic Oncology in Turkey in conjunction with the Nuclear Medicine Department of Cerrahpasa School of Medicine, Istanbul University. Patients were accrued from eight centres. Patients with high-risk and very high-risk disease scheduled to undergo surgical treatment with extended LN dissection between July 2014 and October 2015 were included...
June 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#6
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28550611/-18-f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-malignancy-in-patients-with-paraneoplastic-neurological-syndrome-a-systematic-review-and-meta-analysis
#7
REVIEW
Ana María García Vicente, Roberto C Delgado-Bolton, Mariano Amo-Salas, Jesús López-Fidalgo, Ana Paula Caresia Aróztegui, José Ramón García Garzón, Javier Orcajo Rincón, María José García Velloso, María de Arcocha Torres, Soledad Alvárez Ruíz
PURPOSE: The detection of occult cancer in patients suspected of having a paraneoplastic neurological syndrome (PNS) poses a diagnostic challenge. The aim of our study was to perform a systematic review and meta-analysis to assess the diagnostic performance of FDG PET for the detection of occult malignant disease responsible for PNS. METHODS: A systematic review of the literature (MEDLINE, EMBASE, Cochrane, and DARE) was undertaken to identify studies published in any language...
August 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28541775/cellular-response-to-exponentially-increasing-and-decreasing-dose-rates-implications-for-treatment-planning-in-targeted-radionuclide-therapy
#8
Jay H Solanki, Thomas Tritt, Jordan B Pasternack, Julia J Kim, Calvin N Leung, Jason D Domogauer, Nicholas W Colangelo, Venkat R Narra, Roger W Howell
The treatment of cancer using targeted radionuclide therapy is of interest to nuclear medicine and radiation oncology because of its potential for killing tumor cells while minimizing dose-limiting toxicities to normal tissue. The ionizing radiations emitted by radiopharmaceuticals deliver radiation absorbed doses over protracted periods of time with continuously varying dose rates. As targeted radionuclide therapy becomes a more prominent part of cancer therapy, accurate models for estimating the biologically effective dose (BED) or equieffective dose (EQD2α/β) will become essential for treatment planning...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28476712/prevalence-and-diagnostic-of-head-and-neck-cancer-in-pakistan
#9
Azeem Akhtar, Ijaz Hussain, Muhammad Talha, Muhammad Shakeel, Muhammad Faisal, Muhammad Ameen, Tajammal Hussain
Head and Neck (HN) cancer is the most frequently identified cancer across the globe and is considered as 8-10 % of all cancers in Southeast Asia. The social and cultural habits are the main cause of the remarkable increase in HN cancer in Pakistan. HN cancers are more prevalent in men as compared to women. The HN cancer in Pakistan is mainly attributed to discrete demographic profile, risk elements, eating patterns and family history. The foremost factors of risk are linked with cigarette smoking, alcoholic drinks and tobacco chewing like paan, gutka, etc...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28441368/skeletal-scintigraphy
#10
Jaime L Montilla-Soler, Rikesh Makanji
BACKGROUND: Skeletal scintigraphy remains a valuable tool in the initial and subsequent evaluation of the skeletal system in patients with a diagnosis of primary or metastatic neoplasms. METHODS: We discuss radiopharmaceuticals, nuclear medicine imaging techniques, and current as well as future oncological applications in the adult population. Pertinent literature was reviewed to describe the advantages and limitations of available technologies for the evaluation of skeletal metastatic disease...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28438082/radioimmunoconjugates-for-treating-cancer-recent-advances-and-current-opportunities
#11
Mickaël Bourgeois, Clément Bailly, Mathieu Frindel, François Guerard, Michel Chérel, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré, Caroline Bodet-Milin
Radioimmunoconjugates have been used for 30 years to diagnose and treat cancer. For many years, the use of these therapeutic tools has been limited to haematological disorders, such as non-Hodgkin's lymphoma, given that they have only had a moderate effect on solid tumours. Areas covered: Recently, several strategies have revived the potential therapeutic application for radioimmunoconjugates. In this review, the authors review the advances in immunological engineering to develop new tools like monoclonal antibodies and their derivatives...
July 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28396911/molecularly-targeted-therapies-in-cancer-a-guide-for-the-nuclear-medicine-physician
#12
REVIEW
S Lheureux, C Denoyelle, P S Ohashi, J S De Bono, F M Mottaghy
Molecular imaging continues to influence every aspect of cancer care including detection, diagnosis, staging and therapy response assessment. Recent advances in the understanding of cancer biology have prompted the introduction of new targeted therapy approaches. Precision medicine in oncology has led to rapid advances and novel approaches optimizing the use of imaging modalities in cancer care, research and development. This article focuses on the concept of targeted therapy in cancer and the challenges that exist for molecular imaging in cancer care...
August 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28391026/radiopharmaceuticals-in-the-elderly-cancer-patient-practical-considerations-with-a-focus-on-prostate-cancer-therapy-a-position-paper-from-the-international-society-of-geriatric-oncology-task-force
#13
John O Prior, Silke Gillessen, Manfred Wirth, William Dale, Matti Aapro, Wim J G Oyen
Molecular imaging using radiopharmaceuticals has a clear role in visualising the presence and extent of tumour at diagnosis and monitoring response to therapy. Such imaging provides prognostic and predictive information relevant to management, e.g. by quantifying active tumour mass using positron emission tomography/computed tomography (PET/CT). As these techniques require only pharmacologically inactive doses, age and potential frailty are generally not important. However, this may be different for therapy involving radionuclides because the radiation can impact normal bodily function (e...
May 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28368988/diagnostic-value-of-technetium-99m-bone-scintigraphy-in-the-detection-of-cervical-spine-metastases-in-oncological-patients
#14
Sang-Min Park, Jae-Woo Park, Hui-Jong Lee, Ja-Young Choi, Hye Jin Yoo, Choon-Ki Lee, Bong-Soon Chang, Hyoungmin Kim
STUDY DESIGN: A retrospective cohort, radiographic study. OBJECTIVE: To assess the diagnostic accuracy of bone scintigraphy (BS) for the detection of cervical spine metastases in oncological patients. SUMMARY OF BACKGROUND DATA: BS remains the modality of choice for the screening of bone metastases, because of its feasibility in whole-body scanning and its widespread availability at low cost. Current practice guidelines for patients with malignant diseases recommend BS imaging as the primary screening method for detecting both axial and appendicular skeletal metastases...
March 31, 2017: Spine
https://www.readbyqxmd.com/read/28300723/nuclear-medicine-for-photodynamic-therapy-in-cancer-planning-monitoring-and-nuclear-pdt
#15
REVIEW
Dris Kharroubi Lakouas, Damien Huglo, Serge Mordon, Maximilien Vermandel
Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of light delivered to photosensitized cells. At different stages of delivery, PDT requires imaging to plan, evaluate and monitor treatment. The contribution of molecular imaging in this context is important and continues to increase. In this article, we review the contribution of nuclear medicine imaging in oncology to PDT for planning and therapeutic monitoring purposes...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28237001/radioiodine-therapy
#16
REVIEW
Markus Luster, Andreas Pfestroff, Heribert Hänscheid, Frederik A Verburg
Radioiodine therapy for benign and malignant thyroid disease rose at the birth of nuclear medicine. Since then, this procedure has been performed countless of times in adult and in pediatric patients alike, and has contributed to a normalization of life expectancy in all but I-131 refractory differentiated thyroid cancer (DTC) cases. As (131)I therapy in children is almost exclusively given for DTC, this review of radioiodine therapy in children focuses on patients with malignant thyroid disease. The aim of the present review is to provide an overview of the indications, practical execution, and controversies surrounding (131)I therapy for malignant tumors in pediatric patients...
March 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28179691/impact-of-brachytherapy-applicators-geometry-on-dose-distribution-in-gynaecological-cancer
#17
Ateeque Ur Rehman, Saeed Ahmad Buzdar, Muhammad Hassan, Asghar Gadi, Muhammad Afzal Khan, Muhammad Naeem Anjum
OBJECTIVE: To evaluate the efficacy of suitable applicators for intracavitary brachytherapy to treat cervical cancer. METHODS: This study was conducted at the Bahawalpur Institute of Nuclear Medicine and Oncology, Bahawalpur, Pakistan, in February 2014. Dose distributions for Fletcher and ring applicators were analysed at target points according to recommended protocols using Abacus software. The doses to the organs at risk, i.e. bladder and rectum, were also focused...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28102961/assessing-the-use-of-4dct-ventilation-in-pre-operative-surgical-lung-cancer-evaluation
#18
Yevgeniy Vinogradskiy, Matthew Jackson, Leah Schubert, Bernard Jones, Richard Castillo, Edward Castillo, Thomas Guerrero, John Mitchell, Chad Rusthoven, Moyed Miften, Brian Kavanagh
PURPOSE: A primary treatment option for lung cancer patients is surgical resection. Patients who have poor lung function prior to surgery are at increased risk of developing serious and life-threatening complications after surgical resection. Surgeons use nuclear medicine ventilation-perfusion (VQ) scans along with pulmonary function test (PFT) information to assess a patient's pre-surgical lung function. The nuclear medicine images and pre-surgery PFTs are used to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung tissue that would be lost with surgical resection...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28048542/we-ab-bra-06-4dct-ventilation-a-novel-imaging-modality-for-thoracic-surgical-evaluation
#19
Y Vinogradskiy, M Jackson, L Schubert, B Jones, R Castillo, E Castillo, T Guerrero, J Mitchell, B Kavanagh, M Miften
PURPOSE: The current standard-of-care imaging used to evaluate lung cancer patients for surgical resection is nuclear-medicine ventilation. Surgeons use nuclear-medicine images along with pulmonary function tests (PFT) to calculate percent predicted postoperative (%PPO) PFT values by estimating the amount of functioning lung that would be lost with surgery. 4DCT-ventilation is an emerging imaging modality developed in radiation oncology that uses 4DCT data to calculate lung ventilation maps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047744/we-a-201-01-memorial-introduction
#20
C Marshall
Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
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