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Oxicodone/naloxone

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https://www.readbyqxmd.com/read/7824069/dihydrocodeinone-hydrazone-dihydrocodeinone-oxime-naloxone-3-ome-oxime-and-clocinnamox-fail-to-irreversibly-inhibit-opioid-kappa-receptor-binding
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Q Ni, H Xu, J S Partilla, B R de Costa, K C Rice, A Borsodi, S Hosztafi, R B Rothman
Previous work from our lab identified two subtypes of the opioid kappa receptor. Whereas the kappa1 receptor can be labeled by [3H]U69,593 (5 alpha,7 alpha,8 beta-(-)- N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl]-phenyl- benzeneacetamide), the kappa2 receptor can be labeled by [125I]OXY (6 beta-125iodo-3,14-dihydroxy-17-cyclopropylmethyl-4,5 alpha-epoxymorphinan). Other data demonstrate that [125I]IOXY, like [3H]bremazocine, labels two populations of kappa2 receptors in guinea pig brain: kappa2a and kappa2b binding sites...
September 1994: Neurochemical Research
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