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Anne E Kazak, Michele A Scialla, Andrea F Patenaude, Kimberly Canter, Anna C Muriel, Mary Jo Kupst, Fang Fang Chen, Lori Wiener
OBJECTIVE: This paper presents data on licensure/certification status, supervision of multidisciplinary pediatric psychosocial staff, and training opportunities in pediatric cancer programs in the United States (U.S.), data that is critical to provide care aligned with the Standards of Psychosocial Care in Pediatric Cancer (Psychosocial Standards). METHODS: An online survey of psychosocial care consistent with the Psychosocial Standards was completed from a national sample of pediatric cancer programs (144/200)...
September 22, 2018: Psycho-oncology
Ruiqi Zhu, Wenyi Lin, Weiwei Zhao, Fengjuan Fan, Liang Tang, Yu Hu
Acute myeloid leukemia (AML) is a hematologic malignancy with significant molecular heterogeneity. MicroRNAs (miRNAs) play a critical role in AML diagnosis, pathogenesis, and prognosis of AML. Little has been done to identify a miRNA signature in pediatric and adolescent patients for predicting overall survival. This study aims to identify a panel of miRNA signature that could predict the prognosis of all younger AML patients with all subtypes of AML by analyzing data from The Cancer Genome Atlas (TCGA). A total of 229 patients under 23 years with miRNA data and corresponding clinical data from TCGA database were enrolled in this study...
September 22, 2018: Journal of Cellular Biochemistry
Anava A Wren, K T Park
As clinicians have begun to provide targeted pharmacotherapy for children with inflammatory bowel disease (IBD), several ethical challenges have arisen. In this paper, we review 3 challenges related to applying a precision health approach to pediatric IBD populations: selection of a disease monitoring method, pharmacotherapy optimization, and economic considerations in clinical decision making.
September 1, 2018: AMA Journal of Ethics
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asthma Deeb, Kenneth W Strauss
INTRODUCTION: The 2015 Insulin Injection Technique Questionnaire survey involving 13,289 patients included 898 (6.8%) patients in the pediatric age range (≤ 18 years). METHODS: The younger patients included in the questionnaire survey were grouped according to age: Group 1 (G1), 0-6 years, n = 85; Group 2(G2), 7-13, n = 423; Group 3 (G3), 14-18, n = 390. The injection technique was evaluated by means of a questionnaire and nurse assessment. RESULTS: Nurses found lipohypertrophy at injection sites in 41...
September 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Julia Gesing, Julia Hoppmann, Roman Gebauer, Roland Pfäffle, Astrid Bertsche, Wieland Kiess
Amiodarone-induced hyperthyroidism is a known side effect of amiodarone treatment. In the pediatric population, long-term amiodarone treatment is rarely indicated because of its severe side effects including thyroid function impairment. Treatment is therefore restricted to therapy-resistant arrhythmias. In the literature, scarce data are available on the management and therapy of amiodarone-induced thyroid dysfunction at a young age. We present three adolescent patients developing amiodarone-induced thyrotoxicosis in the months after amiodarone therapy...
September 21, 2018: Pediatric Cardiology
Jonathan R Dillman, Andrew T Trout, Matthew S Davenport
The use of contrast materials as part of imaging examinations is common in children of all ages, as these compounds increase image contrast, lesion detection and lesion characterization. Though modern iodinated, gadolinium-based and ultrasound microbubble contrast materials generally are quite safe, acute physiological and allergic-like reactions are possible. The majority of acute contrast reactions in children are mild and self-limited; however, life-threatening reactions can occur. It is our obligation as radiologists to recognize and manage these adverse reactions...
September 21, 2018: Pediatric Radiology
Evelyn K Hsu, Simon P Horslen, Jorge D Reyes
No abstract text is available yet for this article.
September 17, 2018: JAMA Pediatrics
Nadim Mahmud, Melissa M Gadsden, David S Goldberg
No abstract text is available yet for this article.
September 17, 2018: JAMA Pediatrics
Chung-Chou H Chang, Cindy L Bryce, Benjamin L Shneider, Jonathan G Yabes, Yi Ren, Gabriel L Zenarosa, Heather Tomko, Drew M Donnell, Robert H Squires, Mark S Roberts
Importance: Fair allocation of livers between pediatric and adult recipients is critically dependent on the accuracy of mortality estimates afforded by the Pediatric End-stage Liver Disease (PELD) and Model for End-stage Liver Disease, respectively. Widespread reliance on exceptions for pediatric recipients suggests that the 2 systems may not be comparable. Objective: To evaluate the accuracy of the PELD score in estimating 90-day pretransplant mortality among pediatric patients on the United Network for Organ Sharing (UNOS) waiting list...
September 17, 2018: JAMA Pediatrics
Beth S Slomine, Faye S Silverstein, James R Christensen, Kent Page, Richard Holubkov, J Michael Dean, Frank W Moler
Importance: Little is known about neuropsychological outcomes of children who survived pediatric cardiac arrest (CA). Objective: To describe the neuropsychological outcomes of CA survivors enrolled in the Therapeutic Hypothermia After Pediatric Cardiac Arrest In-Hospital (THAPCA-IH) and Out-of-Hospital (THAPCA-OH) trials and compare the results with the primary outcome measure for these trials. Design, Setting, and Participants: Secondary analysis of 222 CA survivors aged 1 to 18 years who received chest compressions for 2 minutes or more, remained comatose and required mechanical ventilation after return of circulation, and were enrolled in targeted temperature-management trials from 41 pediatric intensive care units...
September 17, 2018: JAMA Neurology
Victoria A Jordan, Loren P Herrera Hernandez, Shelagh A Cofer, Brianne B Roby
No abstract text is available yet for this article.
September 13, 2018: JAMA Otolaryngology—Head & Neck Surgery
Mari Wilhelmsson, Heidi Glosli, Marianne Ifversen, Jonas Abrahamsson, Jacek Winiarski, Kirsi Jahnukainen, Henrik Hasle
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) improves event-free survival in acute myeloid leukemia (AML); however, the burden of late effects may be increased. We compared health-related outcomes in childhood AML survivors treated according to the NOPHO-AML protocols either with or without allo-HSCT at age < 21 years. Out of the 147 eligible AML survivors treated with allo-HSCT, 95 (65%) and 53 (75%) of their eligible siblings completed a questionnaire. Their data were compared to corresponding data collected previously from NOPHO-AML survivors treated with chemotherapy only (CT) (n = 101)...
September 21, 2018: Bone Marrow Transplantation
Guido Frosina, Jean Louis Ravetti, Renzo Corvò, Mauro Fella, Maria Luisa Garrè, Fabrizio Levrero, Diana Marcello, Daniela Marubbi, Giovanni Morana, Michele Mussap, Carlo Emanuele Neumaier, Aldo Profumo, Alessandro Raso, Francesca Rosa, Stefano Vagge, Donatella Vecchio, Antonio Verrico, Gianluigi Zona, Antonio Daga
It has been reported that the ATM kinase inhibitor KU60019 preferentially radiosensitizes orthotopic high grade gliomas (HGG) driven by established U87 and U1242 cell lines bearing specific TP53 mutations. We wished to determine whether those results could be extended to tumors driven by primary glioma initiating cells (GIC) that closely mimic clinical tumors. Orthotopic HGG were developed in immunodeficient non-obese diabetic-severe combined immunodeficient (NOD-SCID) mice by intracranial injection of primary GIC isolated from the adult glioblastoma COMI (acronym of patient's name) and the pediatric anaplastic astrocytoma 239/12...
September 21, 2018: Scientific Reports
Omar Alkandari, Lieuko Nguyen, Diane Hebert, Valerie Langlois, Natasha A Jawa, Rulan S Parekh, Lisa A Robinson
BACKGROUND AND OBJECTIVES: AKI is associated with progression of CKD. Little is known about AKI after kidney transplantation in pediatric recipients. We aim to describe the epidemiology, risk factors, consequences, and outcomes of AKI in this population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a retrospective longitudinal analysis of pediatric kidney transplant recipients followed at The Hospital for Sick Children (Toronto, Canada) from 2001 to 2012...
September 21, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Caroline Dutil, Jeremy J Walsh, Ryan B Featherstone, Katie E Gunnell, Mark S Tremblay, Reut Gruber, Shelly K Weiss, Kimberly A Cote, Margaret Sampson, Jean-Philippe Chaput
This systematic review examined the associations between sleep and brain functions and structures in children and adolescents aged 1-17 ys. Included studies (n = 24) were peer-reviewed and met the a priori determined population (apparently healthy children and adolescents aged 1 y to 17 ys), intervention/exposure/comparator (various sleep characteristics including duration, architecture, quality, timing), and outcome criteria (brain functions and/or brain structures, excluding cognitive function outcomes)...
August 15, 2018: Sleep Medicine Reviews
David Mo, Nathan N O'Hara, Ross Hengel, Alexander R Cheong, Ash Singhal
OBJECTIVE: Leaders of a pediatric trauma team are tasked with managing rapidly changing diagnostic and treatment challenges, while ensuring the entire team functions effectively to produce optimal patient outcomes. An effective trauma team leader is often thought to be self-evident, and there is little formal literature identifying the leadership characteristics and attributes associated with optimal trauma team performance. The purpose of this study was to elicit the trauma team leader traits and characteristics deemed of greatest utility by members of the pediatric trauma team...
September 18, 2018: Journal of Surgical Education
Sharman P Tan Tanny, Minjung Yoo, John M Hutson, Jacob C Langer, Sebastian K King
BACKGROUND: Surgical management of adult ulcerative colitis (UC) is well-studied, but not readily applicable to children. Restorative proctocolectomy with ileal pouch-anal anastomosis (RPC-IPAA), performed as one-, two-, or three-stage procedure, is preferred in pediatric patients with adequate anal sphincter function. PURPOSE: METHODS: Systematic review of Cochrane Register of Controlled Trials, PubMed, and EMBASE databases was conducted (January 1987-December 2016), in accordance with PRISMA...
September 7, 2018: Journal of Pediatric Surgery
K Tinsley Anderson, Marisa A Bartz-Kurycki, Dalya M Ferguson, Akemi L Kawaguchi, Mary T Austin, Lillian S Kao, Kevin P Lally, KuoJen Tsao
BACKGROUND: Opioid misuse is a public health crisis in the United States. This study aimed to evaluate the discharge opioid prescription practices for pediatric simple appendectomy patients. METHODS: A retrospective review of pediatric appendectomy patients at a tertiary children's hospital was conducted from October 2016 to January 2018. Only patients with simple appendicitis were included. Written opioid prescriptions were found in the electronic medical record (EMR) or through a statewide prescription monitoring database...
September 2, 2018: Journal of Pediatric Surgery
Gia Chodzen, Marco A Hidalgo, Diane Chen, Robert Garofalo
PURPOSE: Transgender and gender-nonconforming (TGNC) adolescents and young adults experience mental health problems, including anxiety and depression, at an elevated rate as compared to their cisgender counterparts. A growing literature suggests that vulnerability to psychiatric problems in TGNC individuals results from social discrimination and minority stress. METHODS: The sample consisted of adolescent TGNC patients (N = 109) who completed behavior health screening questionnaires as standard of care at their first clinical visit to an interdisciplinary gender program within a pediatric academic medical center in a metropolitan Midwestern city...
September 18, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Robert Steffen
Tick-borne encephalitis (TBE) vaccination recommendations for children residing in high-endemicity countries in Europe vary from universal recommendations to none at all. Such differences may result in uncertainty about the value of such prevention among public health authorities, healthcare professionals and parents. We conducted a systematic review of publications and data from the European Centres for Disease Prevention and Control focusing on the epidemiology, clinical characteristics, and outcomes of TBE in a pediatric population...
September 1, 2018: Ticks and Tick-borne Diseases
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