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https://www.readbyqxmd.com/read/28449491/characteristics-and-provision-of-care-of-patients-with-the-acute-respiratory-distress-syndrome-descriptive-findings-from-the-dacapo-cohort-baseline-and-comparison-with-international-findings
#1
Frank Dodoo-Schittko, Susanne Brandstetter, Magdalena Brandl, Sebastian Blecha, Michael Quintel, Steffen Weber-Carstens, Stefan Kluge, Patrick Meybohm, Caroline Rolfes, Björn Ellger, Friedhelm Bach, Tobias Welte, Thomas Muders, Kathrin Thomann-Hackner, Thomas Bein, Christian Apfelbacher
BACKGROUND: Little is known about the characteristics and real world life circumstances of ARDS (acute respiratory distress syndrome) patient populations. This knowledge is essential for transferring evidence-based therapy into routine healthcare. The aim of this study was to report socio-demographic and clinical characteristics in an unselected population of ARDS patients and to compare these results to findings from other large ARDS cohorts. METHODS: A German based cross-sectional observational study was carried out...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28395697/psychometric-properties-of-the-extended-nursing-stress-scale-measuring-stress-in-workplace
#2
Muder Alkrisat, Manal Alatrash
BACKGROUND: Despite its popularity, the psychometric properties of the Extended Nursing Stress Scale (ENSS) in working adults are yet to be evaluated in different settings. METHODS: This study examined the ENSS in acute care settings among licensed nurses through a questionnaire survey. The sample responses were examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). RESULTS: A response rate of 37% was achieved; 199 licensed nurses completed the questionnaire...
April 1, 2017: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28274938/sex-specific-differences-in-age-dependent-progression-of-aortic-dysfunction-and-related-cardiac-remodeling-in-spontaneously-hypertensive-rats
#3
Suzan Al-Gburi, Andreas Johannes Deussen, Roberta Galli, Michael H Muders, Birgit Zatschler, Anja Neisser, Bianca Müller, Irakli Kopaliani
Sex-specific differences in renin-angiotensin-system (RAS) and arterial pressure have been evidenced in many mammals including spontaneously hypertensive rats (SHRs). Although SHRs have been used extensively as a leading experimental model of hypertension, effects of sex-specific differences in RAS on aortic function and related cardiac remodeling during aging and hypertension have not been documented in detail. We examined structural and functional changes in aorta and heart of female and male SHRs at ages of 5, 14, 29 and 36-weeks...
March 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28224232/effects-of-traumeel-tr14-on-recovery-and-inflammatory-immune-response-after-repeated-bouts-of-exercise-a-double-blind-rct
#4
RANDOMIZED CONTROLLED TRIAL
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
PURPOSE: The purpose of this double-blind, randomized, placebo-controlled clinical trial was to investigate the effects of the natural combination medicine Traumeel (Tr14) consisting of 14 diluted biological and mineral components on the inflammatory immune response and recovery up to 72 h after repetitive bouts of bicycle tests. METHODS: Antigen-stimulated IL-1ra and IL-6 were defined as primary outcome measures. Moreover, various immunological and serum muscle damage markers were investigated...
March 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28191009/defective-il-23-il-17-axis-protects-p47phox-mice-from-colon-cancer
#5
Cornelia Richter, Martina Herrero San Juan, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H Muders, Gustavo B Baretton, Josef Martin Pfeilschifter, Halvard Bonig, Sebastian Brenner, Heinfried H Radeke
In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28079607/mapping-regional-differences-of-local-pressure-volume-curves-with-electrical-impedance-tomography
#6
Alessandro Beda, Alysson R Carvalho, Nadja C Carvalho, Sören Hammermüller, Marcelo B P Amato, Thomas Muders, Claudia Gittel, Katharina Noreikat, Hermann Wrigge, Andreas W Reske
OBJECTIVES: Lung-protective mechanical ventilation aims to prevent alveolar collapse and overdistension, but reliable bedside methods to quantify them are lacking. We propose a quantitative descriptor of the shape of local pressure-volume curves derived from electrical impedance tomography, for computing maps that highlight the presence and location of regions of presumed tidal recruitment (i.e., elastance decrease during inflation, pressure-volume curve with upward curvature) or overdistension (i...
April 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28063356/nanoparticles-for-radiooncology-mission-vision-challenges
#7
REVIEW
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner, Samuel Schellenburg, Michael H Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma, Rainer Tietze, Christoph Alexiou, Holger Stephan, Kristof Zarschler, Orazio Vittorio, Maria Kavallaris, Wolfgang J Parak, Lutz Mädler, Suman Pokhrel
Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells...
December 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/27478305/effects-of-traumeel-tr14-on-exercise-induced-muscle-damage-response-in-healthy-subjects-a-double-blind-rct
#8
RANDOMIZED CONTROLLED TRIAL
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27360382/effects-of-a-natural-combination-medicine-on-exercise-induced-muscle-soreness-1463-board-116-june-2-8-00-am-9-30-am
#9
Christian Pilat, Kerstin Muders, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Christine Scheibelhut, Frank-Christoph Mooren
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27307593/pi3k-pathway-inhibition-achieves-potent-antitumor-activity-in-melanoma-brain-metastases-in-vitro-and-in-vivo
#10
Heike Niessner, Jennifer Schmitz, Ghazaleh Tabatabai, Andreas M Schmid, Carsten Calaminus, Tobias Sinnberg, Benjamin Weide, Thomas K Eigentler, Claus Garbe, Birgit Schittek, Leticia Quintanilla-Fend, Benjamin Bender, Marion Mai, Christian Praetorius, Stefan Beissert, Gabriele Schackert, Michael H Muders, Matthias Meinhardt, Gustavo B Baretton, Reinhard Dummer, Keith Flaherty, Bernd J Pichler, Dagmar Kulms, Dana Westphal, Friedegund Meier
PURPOSE: Great advances have recently been made in treating patients with metastatic melanoma. However, existing therapies are less effective on cerebral than extracerebral metastases. This highlights the potential role of the brain environment on tumor progression and drug resistance and underlines the need for "brain-specific" therapies. We previously showed that the PI3K-AKT survival pathway is hyperactivated in brain but not extracerebral melanoma metastases and that astrocyte-conditioned medium activates AKT in melanoma cells in vitro We therefore tested the PI3K inhibitor buparlisib as an antitumor agent for melanoma brain metastases...
December 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27243279/improving-the-diagnosis-of-legionella-pneumonia-within-a-healthcare-system-through-a-systematic-consultation-and-testing-program
#11
Brooke K Decker, Patricia L Harris, Robert R Muder, Jae H Hong, Nina Singh, Ali F Sonel, Cornelius J Clancy
RATIONALE: Legionella testing is not recommended for all patients with pneumonia, but rather for particular patient subgroups. As a result, the overall incidence of Legionella pneumonia may be underestimated. OBJECTIVES: To determine the incidence of Legionella pneumonia in a veteran population in an endemic area after introduction of a systematic infectious diseases consultation and testing program. METHODS: In response to a 2011-2012 outbreak, the VA Pittsburgh Healthcare System mandated infectious diseases consultations and testing for Legionella by urine antigen and sputum culture in all patients with pneumonia...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27191011/femtosecond-infrared-spectroscopy-of-channelrhodopsin-1-chromophore-isomerization
#12
T Stensitzki, Y Yang, V Muders, R Schlesinger, J Heberle, K Heyne
Vibrational dynamics of the retinal all-trans to 13-cis photoisomerization in channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by femtosecond visible pump mid-IR probe spectroscopy. After photoexcitation, the transient infrared absorption of C-C stretching modes was detected. The formation of the 13-cis photoproduct marker band at 1193 cm(-1) was observed within the time resolution of 0.3 ps. We estimated the photoisomerization yield to (60 ± 6) %. We found additional time constants of (0...
July 2016: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/27183117/apoptosis-of-t-cell-subsets-after-acute-high-intensity-interval-exercise
#13
Karsten Krüger, Katharina Alack, Robert Ringseis, Lena Mink, Elisabeth Pfeifer, Matthias Schinle, Katharina Gindler, Lena Kimmelmann, Rüdiger Walscheid, Kerstin Muders, Torsten Frech, Klaus Eder, Frank-Christoph Mooren
INTRODUCTION: High-intensity interval training (HIT) exercise has gained much interest in both performance and recreational sports. This study aims to compare the effect of HIT versus continuous (CONT) exercise with regard to changes of circulating T cells and progenitor cells. METHODS: Subjects (n = 23) completed an HIT test and an isocaloric CONT test. Blood samples were collected before, immediately after, and 3 and 24 h postexercise for the assessment of low differentiated (CD3CD28CD57), highly differentiated T cells (CD3CD28CD57), regulatory T cells (Tregs) (CD4CD25CD127), hematopoietic progenitor cells (CD45CD34), and endothelial progenitor cells (CD45CD34KDR) by flow cytometry...
October 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27142456/the-phytoestrogenic-cyclopia-extract-sm6met-increases-median-tumor-free-survival-and-reduces-tumor-mass-and-volume-in-chemically-induced-rat-mammary-gland-carcinogenesis
#14
Koch Visser, Oliver Zierau, Dana Macejová, Florian Goerl, Michael Muders, Gustavo B Baretton, Günter Vollmer, Ann Louw
SM6Met, a phytoestrogenic extract of Cyclopia subternata indigenous to the Western Cape province of South Africa, displays estrogenic attributes with potential for breast cancer chemoprevention. In this study, we report that SM6Met, in the presence of estradiol, induces a significant cell cycle G0/G1 phase arrest similar to the selective estrogen receptor modulator, tamoxifen. Furthermore, as a proof of concept, in the N-Methyl-N-nitrosourea induced rat mammary gland carcinogenesis model, SM6Met increases tumor latency by 7days and median tumor free survival by 42 days, while decreasing palpable tumor frequency by 32%, tumor mass by 40%, and tumor volume by 53%...
October 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27060915/the-effect-of-sdf-1%C3%AE-on-low-dose-bmp-2-mediated-bone-regeneration-by-release-from-heparinized-mineralized-collagen-type-i-matrix-scaffolds-in-a-murine-critical-size-bone-defect-model
#15
Stefan Zwingenberger, Robert Langanke, Corina Vater, Geoffrey Lee, Eik Niederlohmann, Markus Sensenschmidt, Angela Jacobi, Ricardo Bernhardt, Michael Muders, Stefan Rammelt, Sven Knaack, Michael Gelinsky, Klaus-Peter Günther, Stuart B Goodman, Maik Stiehler
The treatment of critical size bone defects represents a challenge. The growth factor bone morphogenetic protein 2 (BMP-2) is clinically established but has potentially adverse effects when used at high doses. The aim of this study was to evaluate if stromal derived factor-1 alpha (SDF-1α) and BMP-2 released from heparinized mineralized collagen type I matrix (MCM) scaffolds have a cumulative effect on bone regeneration. MCM scaffolds were functionalized with heparin, loaded with BMP-2 and/or SDF-1α and implanted into a murine critical size femoral bone defect (control group, low dose BMP-2 group, low dose BMP-2 + SDF-1α group, and high dose BMP-2 group)...
September 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27026195/nrp2-transcriptionally-regulates-its-downstream-effector-wdfy1
#16
Samikshan Dutta, Sohini Roy, Navatha S Polavaram, Gustavo B Baretton, Michael H Muders, Surinder Batra, Kaustubh Datta
Neuropilins (NRPs) are cell surface glycoproteins that often act as co-receptors for plexins and VEGF family receptors. Neuropilin-2 (NRP2), a family member of NRPs, was shown to regulate autophagy and endocytic trafficking in cancer cells, a function distinctly different from its role as a co-receptor. WD Repeat and FYVE domain containing 1 (WDFY1)-protein acts downstream of NRP2 for this function. Our results indicated that NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression...
March 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26999496/vibronic-dynamics-of-the-ultrafast-all-trans-to-13-cis-photoisomerization-of-retinal-in-channelrhodopsin-1
#17
Christoph Schnedermann, Vera Muders, David Ehrenberg, Ramona Schlesinger, Philipp Kukura, Joachim Heberle
Channelrhodopsins are light-gated ion channels with extensive applications in optogenetics. Channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) exhibits a red-shifted absorption spectrum as compared to Channelrhodopsin-2, which is highly beneficial for optogenetic application. The primary event in the photocycle of CaChR1 involves an isomerization of the protein-bound retinal chromophore. Here, we apply highly time-resolved vibronic spectroscopy to reveal the electronic and structural dynamics associated with the first step of the photocycle of CaChR1...
April 13, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/26996788/short-interspersed-nuclear-elements-sines-are-abundant-in-solanaceae-and-have-a-family-specific-impact-on-gene-structure-and-genome-organization
#18
COMPARATIVE STUDY
Kathrin M Seibt, Torsten Wenke, Katja Muders, Bernd Truberg, Thomas Schmidt
Short interspersed nuclear elements (SINEs) are highly abundant non-autonomous retrotransposons that are widespread in plants. They are short in size, non-coding, show high sequence diversity, and are therefore mostly not or not correctly annotated in plant genome sequences. Hence, comparative studies on genomic SINE populations are rare. To explore the structural organization and impact of SINEs, we comparatively investigated the genome sequences of the Solanaceae species potato (Solanum tuberosum), tomato (Solanum lycopersicum), wild tomato (Solanum pennellii), and two pepper cultivars (Capsicum annuum)...
May 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/26984757/an-epigenetic-reprogramming-strategy-to-resensitize-radioresistant-prostate-cancer-cells
#19
Claudia Peitzsch, Monica Cojoc, Linda Hein, Ina Kurth, Katrin Mäbert, Franziska Trautmann, Barbara Klink, Evelin Schröck, Manfred P Wirth, Mechthild Krause, Eduard A Stakhovsky, Gennady D Telegeev, Vladimir Novotny, Marieta Toma, Michael Muders, Gustavo B Baretton, Fiona M Frame, Norman J Maitland, Michael Baumann, Anna Dubrovska
Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to a population of cancer stem cells (CSC) that survives radiotherapy, analysis of this cell population might illuminate tactics to personalize treatment. However, this direction remains challenging given the plastic nature of prostate cancers following treatment. We show here that irradiating prostate cancer cells stimulates a durable upregulation of stem cell markers that epigenetically reprogram these cells...
May 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26957449/natural-good-theories-and-the-value-of-human-dignity
#20
Sebastian Muders
One of the widely recognized facts about human dignity is its vastly divergent applicability-from highly controversial issues in bioethics to broader topics in political philosophy. A group of theories that this article subsumes under the header "natural good theories" appears to be especially fitted for normatively multifaceted notions like dignity. However, the heavy normative weight the concept of dignity has to bear due to the central position it occupies within these theories creates its own difficulties...
April 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
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