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https://www.readbyqxmd.com/read/29173230/water-cultures-are-more-sensitive-than-swab-cultures-for-the-detection-of-environmental-legionella
#1
Brooke K Decker, Patricia L Harris, Diana L Toy, Robert R Muder, Ali F Sonel, Cornelius J Clancy
Water cultures were significantly more sensitive than concurrently collected swab cultures (n=2,147 each) in detecting Legionella pneumophila within a Veterans Affairs healthcare system. Sensitivity for water versus swab cultures was 90% versus 30% overall, 83% versus 48% during a nosocomial Legionnaires' disease outbreak, and 93% versus 22% post outbreak. Infect Control Hosp Epidemiol 2017;1-3.
November 27, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29060676/gamma-variate-modeling-of-indicator-dilution-curves-in-electrical-impedance-tomography
#2
Benjamin Hentze, Thomas Muders, Henning Luepschen, Steffen Leonhardt, Christian Putensen, Marian Walter
Electrical impedance tomography (EIT) is a non-invasive imaging technique, that can be used to monitor regional lung ventilation (V̇) in intensive care units (ICU) at bedside. This work introduces a method to extract regional lung perfusion (Q̇) from EIT image streams in order to quantify regional gas exchange in the lungs. EIT data from a single porcine animal trial, recorded during injection of a contrast agent (NaCl 10%) into a central venous catheter (CVC), are used for evaluation. Using semi-negative matrix factorization (Semi-NMF) a set of source signals is extracted from the data...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28979098/metal-organic-frameworks-as-a-drug-delivery-system-for-flurbiprofen
#3
Muder Al Haydar, Hussein Rasool Abid, Bruce Sunderland, Shaobin Wang
BACKGROUND: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28964928/evaluation-of-estrogenic-potency-of-a-standardized-hops-extract-on-mammary-gland-biology-and-on-mnu-induced-mammary-tumor-growth-in-rats
#4
Annekathrin M Keiler, Dana Macejova, Birgit M Dietz, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Richard B van Breemen, Dejan Nikolic, Florian Goerl, Michael H Muders, Oliver Zierau, Günter Vollmer
Supplements with estrogenic activities are intensively investigated as potential alternatives for the treatment of menopausal symptoms. These investigations include studies on their safety regarding potential breast cancer risks. Therefore, the aim of this study was to assess whether or not a standardized hops (Humulus lupulus) extract, containing 0.42% of the estrogenic flavanone, 8-prenylnaringenin, would stimulate growth of methyl-nitrosourea (MNU) induced mammary cancer in ovariectomized (OVX) Sprague-Dawley (SD) rats or would impact on the proliferative activity within the normal mammary gland of Wistar rats...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28843905/role-of-neuropilin-2-in-the-immune-system
#5
REVIEW
S Schellenburg, A Schulz, D M Poitz, M H Muders
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They are up to 44 % homologous and conserved in all vertebrates. High levels of NRP2 are found on immune cells. Current research is very limited regarding the functions of NRP2 on these cells...
October 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28715385/a-genetically-engineered-mouse-model-of-sporadic-colorectal-cancer
#6
Alexander M Betzler, Susan Kochall, Linda Blickensdörfer, Sebastian A Garcia, May-Linn Thepkaysone, Lahiri K Nanduri, Michael H Muders, Jürgen Weitz, Christoph Reissfelder, Sebastian Schölch
Despite the advantages of easy applicability and cost-effectiveness, colorectal cancer mouse models based on tumor cell injection have severe limitations and do not accurately simulate tumor biology and tumor cell dissemination. Genetically engineered mouse models have been introduced to overcome these limitations; however, such models are technically demanding, especially in large organs such as the colon in which only a single tumor is desired. As a result, an immunocompetent, genetically engineered mouse model of colorectal cancer was developed which develops highly uniform tumors and can be used for tumor biology studies as well as therapeutic trials...
July 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714452/predict-moral-distress-using-workplace-stress-stress-of-conscience-mediated-by-coping-using-roy-adaptation-model-a-path-analysis
#7
Muder Alkrisat
BACKGROUND: Moral distress can be predisposed when nurses are exposed to ambiguous moral situations. PURPOSE: Is to test a conceptual model based on Roy adaptation model (RAM) to examine the relationship among workplace stress, conscience stress, and moral distress mediated by coping. DESIGN: A correlational, cross sectional. RESULTS: Data were collected from 199 licensed nurses. The findings indicated that workplace stress was related negatively to coping processes (β = -...
December 1, 2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28449491/characteristics-and-provision-of-care-of-patients-with-the-acute-respiratory-distress-syndrome-descriptive-findings-from-the-dacapo-cohort-baseline-and-comparison-with-international-findings
#8
Frank Dodoo-Schittko, Susanne Brandstetter, Magdalena Brandl, Sebastian Blecha, Michael Quintel, Steffen Weber-Carstens, Stefan Kluge, Patrick Meybohm, Caroline Rolfes, Björn Ellger, Friedhelm Bach, Tobias Welte, Thomas Muders, Kathrin Thomann-Hackner, Thomas Bein, Christian Apfelbacher
BACKGROUND: Little is known about the characteristics and real world life circumstances of ARDS (acute respiratory distress syndrome) patient populations. This knowledge is essential for transferring evidence-based therapy into routine healthcare. The aim of this study was to report socio-demographic and clinical characteristics in an unselected population of ARDS patients and to compare these results to findings from other large ARDS cohorts. METHODS: A German based cross-sectional observational study was carried out...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28395697/psychometric-properties-of-the-extended-nursing-stress-scale-measuring-stress-in-workplace
#9
Muder Alkrisat, Manal Alatrash
BACKGROUND: Despite its popularity, the psychometric properties of the Extended Nursing Stress Scale (ENSS) in working adults are yet to be evaluated in different settings. METHODS: This study examined the ENSS in acute care settings among licensed nurses through a questionnaire survey. The sample responses were examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). RESULTS: A response rate of 37% was achieved; 199 licensed nurses completed the questionnaire...
April 1, 2017: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28274938/sex-specific-differences-in-age-dependent-progression-of-aortic-dysfunction-and-related-cardiac-remodeling-in-spontaneously-hypertensive-rats
#10
Suzan Al-Gburi, Andreas J Deussen, Roberta Galli, Michael H Muders, Birgit Zatschler, Anja Neisser, Bianca Müller, Irakli Kopaliani
Evidence of sex-specific differences in renin-angiotensin-system (RAS) and arterial pressure has been shown in many mammals, including spontaneously hypertensive rats (SHRs). Although SHRs have been used extensively as a leading experimental model of hypertension, the effects of sex-specific differences in RAS on aortic function and related cardiac remodeling during aging and hypertension have not been documented in detail. We examined structural and functional changes in aorta and heart of female and male SHRs at the ages of 5, 14, 29, and 36 wk...
May 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28224232/effects-of-traumeel-tr14-on-recovery-and-inflammatory-immune-response-after-repeated-bouts-of-exercise-a-double-blind-rct
#11
RANDOMIZED CONTROLLED TRIAL
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
PURPOSE: The purpose of this double-blind, randomized, placebo-controlled clinical trial was to investigate the effects of the natural combination medicine Traumeel (Tr14) consisting of 14 diluted biological and mineral components on the inflammatory immune response and recovery up to 72 h after repetitive bouts of bicycle tests. METHODS: Antigen-stimulated IL-1ra and IL-6 were defined as primary outcome measures. Moreover, various immunological and serum muscle damage markers were investigated...
March 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28191009/defective-il-23-il-17-axis-protects-p47phox-mice-from-colon-cancer
#12
Cornelia Richter, Martina Herrero San Juan, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H Muders, Gustavo B Baretton, Josef Martin Pfeilschifter, Halvard Bonig, Sebastian Brenner, Heinfried H Radeke
In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28079607/mapping-regional-differences-of-local-pressure-volume-curves-with-electrical-impedance-tomography
#13
Alessandro Beda, Alysson R Carvalho, Nadja C Carvalho, Sören Hammermüller, Marcelo B P Amato, Thomas Muders, Claudia Gittel, Katharina Noreikat, Hermann Wrigge, Andreas W Reske
OBJECTIVES: Lung-protective mechanical ventilation aims to prevent alveolar collapse and overdistension, but reliable bedside methods to quantify them are lacking. We propose a quantitative descriptor of the shape of local pressure-volume curves derived from electrical impedance tomography, for computing maps that highlight the presence and location of regions of presumed tidal recruitment (i.e., elastance decrease during inflation, pressure-volume curve with upward curvature) or overdistension (i...
April 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28063356/nanoparticles-for-radiooncology-mission-vision-challenges
#14
REVIEW
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner, Samuel Schellenburg, Michael H Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma, Rainer Tietze, Christoph Alexiou, Holger Stephan, Kristof Zarschler, Orazio Vittorio, Maria Kavallaris, Wolfgang J Parak, Lutz Mädler, Suman Pokhrel
Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/27478305/effects-of-traumeel-tr14-on-exercise-induced-muscle-damage-response-in-healthy-subjects-a-double-blind-rct
#15
RANDOMIZED CONTROLLED TRIAL
Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27360382/effects-of-a-natural-combination-medicine-on-exercise-induced-muscle-soreness-1463-board-116-june-2-8-00-am-9-30-am
#16
Christian Pilat, Kerstin Muders, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Christine Scheibelhut, Frank-Christoph Mooren
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27307593/pi3k-pathway-inhibition-achieves-potent-antitumor-activity-in-melanoma-brain-metastases-in-vitro-and-in-vivo
#17
Heike Niessner, Jennifer Schmitz, Ghazaleh Tabatabai, Andreas M Schmid, Carsten Calaminus, Tobias Sinnberg, Benjamin Weide, Thomas K Eigentler, Claus Garbe, Birgit Schittek, Leticia Quintanilla-Fend, Benjamin Bender, Marion Mai, Christian Praetorius, Stefan Beissert, Gabriele Schackert, Michael H Muders, Matthias Meinhardt, Gustavo B Baretton, Reinhard Dummer, Keith Flaherty, Bernd J Pichler, Dagmar Kulms, Dana Westphal, Friedegund Meier
PURPOSE: Great advances have recently been made in treating patients with metastatic melanoma. However, existing therapies are less effective on cerebral than extracerebral metastases. This highlights the potential role of the brain environment on tumor progression and drug resistance and underlines the need for "brain-specific" therapies. We previously showed that the PI3K-AKT survival pathway is hyperactivated in brain but not extracerebral melanoma metastases and that astrocyte-conditioned medium activates AKT in melanoma cells in vitro We therefore tested the PI3K inhibitor buparlisib as an antitumor agent for melanoma brain metastases...
December 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27243279/improving-the-diagnosis-of-legionella-pneumonia-within-a-healthcare-system-through-a-systematic-consultation-and-testing-program
#18
Brooke K Decker, Patricia L Harris, Robert R Muder, Jae H Hong, Nina Singh, Ali F Sonel, Cornelius J Clancy
RATIONALE: Legionella testing is not recommended for all patients with pneumonia, but rather for particular patient subgroups. As a result, the overall incidence of Legionella pneumonia may be underestimated. OBJECTIVES: To determine the incidence of Legionella pneumonia in a veteran population in an endemic area after introduction of a systematic infectious diseases consultation and testing program. METHODS: In response to a 2011-2012 outbreak, the VA Pittsburgh Healthcare System mandated infectious diseases consultations and testing for Legionella by urine antigen and sputum culture in all patients with pneumonia...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27191011/femtosecond-infrared-spectroscopy-of-channelrhodopsin-1-chromophore-isomerization
#19
T Stensitzki, Y Yang, V Muders, R Schlesinger, J Heberle, K Heyne
Vibrational dynamics of the retinal all-trans to 13-cis photoisomerization in channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by femtosecond visible pump mid-IR probe spectroscopy. After photoexcitation, the transient infrared absorption of C-C stretching modes was detected. The formation of the 13-cis photoproduct marker band at 1193 cm(-1) was observed within the time resolution of 0.3 ps. We estimated the photoisomerization yield to (60 ± 6) %. We found additional time constants of (0...
July 2016: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/27183117/apoptosis-of-t-cell-subsets-after-acute-high-intensity-interval-exercise
#20
Karsten Krüger, Katharina Alack, Robert Ringseis, Lena Mink, Elisabeth Pfeifer, Matthias Schinle, Katharina Gindler, Lena Kimmelmann, Rüdiger Walscheid, Kerstin Muders, Torsten Frech, Klaus Eder, Frank-Christoph Mooren
INTRODUCTION: High-intensity interval training (HIT) exercise has gained much interest in both performance and recreational sports. This study aims to compare the effect of HIT versus continuous (CONT) exercise with regard to changes of circulating T cells and progenitor cells. METHODS: Subjects (n = 23) completed an HIT test and an isocaloric CONT test. Blood samples were collected before, immediately after, and 3 and 24 h postexercise for the assessment of low differentiated (CD3CD28CD57), highly differentiated T cells (CD3CD28CD57), regulatory T cells (Tregs) (CD4CD25CD127), hematopoietic progenitor cells (CD45CD34), and endothelial progenitor cells (CD45CD34KDR) by flow cytometry...
October 2016: Medicine and Science in Sports and Exercise
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