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Kerstin Muders, Christian Pilat, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Frank-Christoph Mooren
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated...
2016: Mediators of Inflammation
Christian Pilat, Kerstin Muders, Vanessa Deuster, Torsten Frech, Karsten Krüger, Jörn Pons-Kühnemann, Christine Scheibelhut, Frank-Christoph Mooren
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Heike Niessner, Jennifer Schmitz, Ghazaleh Tabatabai, Andreas Schmid, Carsten Calaminus, Tobias Sinnberg, Benjamin Weide, Thomas K Eigentler, Claus Garbe, Birgit Schittek, Leticia Quintanilla-Fend, Benjamin Bender, Marion Mai, Christian Praetorius, Stefan Beissert, Gabriele Schackert, Michael Muders, Matthias Meinhardt, Gustavo B Baretton, Reinhard Dummer, Keith T Flaherty, Bernd J Pichler, Dagmar Kulms, Dana Westphal, Friedegund Meier
PURPOSE: Great advances have recently been made in treating patients with metastatic melanoma. However, existing therapies are less effective on cerebral than extracerebral metastases. This highlights the potential role of the brain environment on tumor progression and drug resistance and underlines the need for "brain-specific" therapies. We previously showed that the PI3K-AKT survival pathway is hyperactivated in brain but not extracerebral melanoma metastases and that astrocyte-conditioned medium activates AKT in melanoma cells in vitro...
June 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Brooke K Decker, Patricia L Harris, Robert R Muder, Jae H Hong, Nina Singh, Ali F Sonel, Cornelius J Clancy
RATIONALE: Legionella testing is not recommended for all patients with pneumonia, but rather for particular patient subgroups. As a result, the overall incidence of Legionella pneumonia may be underestimated. OBJECTIVES: To determine the incidence of Legionella pneumonia in a veteran population in an endemic area after introduction of a systematic infectious diseases consultation and testing program. METHODS: In response to a 2011-2012 outbreak, the VA Pittsburgh Healthcare System mandated infectious diseases consultations and testing for Legionella by urine antigen and sputum culture in all patients with pneumonia...
August 2016: Annals of the American Thoracic Society
T Stensitzki, Y Yang, V Muders, R Schlesinger, J Heberle, K Heyne
Vibrational dynamics of the retinal all-trans to 13-cis photoisomerization in channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by femtosecond visible pump mid-IR probe spectroscopy. After photoexcitation, the transient infrared absorption of C-C stretching modes was detected. The formation of the 13-cis photoproduct marker band at 1193 cm(-1) was observed within the time resolution of 0.3 ps. We estimated the photoisomerization yield to (60 ± 6) %. We found additional time constants of (0...
July 2016: Structural Dynamics (Melville, N.Y.)
Karsten Krüger, Katharina Alack, Robert Ringseis, Lena Mink, Elisabeth Pfeifer, Matthias Schinle, Katharina Gindler, Lena Kimmelmann, Rüdiger Walscheid, Kerstin Muders, Torsten Frech, Klaus Eder, Frank-Christoph Mooren
INTRODUCTION: High-intensity interval training (HIT) exercise has gained much interest in both performance and recreational sports. This study aims to compare the effect of HIT versus continuous (CONT) exercise with regard to changes of circulating T cells and progenitor cells. METHODS: Subjects (n = 23) completed an HIT test and an isocaloric CONT test. Blood samples were collected before, immediately after, and 3 and 24 h postexercise for the assessment of low differentiated (CD3CD28CD57), highly differentiated T cells (CD3CD28CD57), regulatory T cells (Tregs) (CD4CD25CD127), hematopoietic progenitor cells (CD45CD34), and endothelial progenitor cells (CD45CD34KDR) by flow cytometry...
October 2016: Medicine and Science in Sports and Exercise
Koch Visser, Oliver Zierau, Dana Macejová, Florian Goerl, Michael Muders, Gustavo B Baretton, Günter Vollmer, Ann Louw
SM6Met, a phytoestrogenic extract of Cyclopia subternata indigenous to the Western Cape province of South Africa, displays estrogenic attributes with potential for breast cancer chemoprevention. In this study, we report that SM6Met, in the presence of estradiol, induces a significant cell cycle G0/G1 phase arrest similar to the selective estrogen receptor modulator, tamoxifen. Furthermore, as a proof of concept, in the N-Methyl-N-nitrosourea induced rat mammary gland carcinogenesis model, SM6Met increases tumor latency by 7days and median tumor free survival by 42 days, while decreasing palpable tumor frequency by 32%, tumor mass by 40%, and tumor volume by 53%...
October 2016: Journal of Steroid Biochemistry and Molecular Biology
Stefan Zwingenberger, Robert Langanke, Corina Vater, Geoffrey Lee, Eik Niederlohmann, Markus Sensenschmidt, Angela Jacobi, Ricardo Bernhardt, Michael Muders, Stefan Rammelt, Sven Knaack, Michael Gelinsky, Klaus-Peter Günther, Stuart B Goodman, Maik Stiehler
The treatment of critical size bone defects represents a challenge. The growth factor bone morphogenetic protein 2 (BMP-2) is clinically established but has potentially adverse effects when used at high doses. The aim of this study was to evaluate if stromal derived factor-1 alpha (SDF-1α) and BMP-2 released from heparinized mineralized collagen type I matrix (MCM) scaffolds have a cumulative effect on bone regeneration. MCM scaffolds were functionalized with heparin, loaded with BMP-2 and/or SDF-1α and implanted into a murine critical size femoral bone defect (control group, low dose BMP-2 group, low dose BMP-2 + SDF-1α group, and high dose BMP-2 group)...
September 2016: Journal of Biomedical Materials Research. Part A
Samikshan Dutta, Sohini Roy, Navatha S Polavaram, Gustavo B Baretton, Michael H Muders, Surinder Batra, Kaustubh Datta
Neuropilins (NRPs) are cell surface glycoproteins that often act as co-receptors for plexins and VEGF family receptors. Neuropilin-2 (NRP2), a family member of NRPs, was shown to regulate autophagy and endocytic trafficking in cancer cells, a function distinctly different from its role as a co-receptor. WD Repeat and FYVE domain containing 1 (WDFY1)-protein acts downstream of NRP2 for this function. Our results indicated that NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression...
2016: Scientific Reports
Christoph Schnedermann, Vera Muders, David Ehrenberg, Ramona Schlesinger, Philipp Kukura, Joachim Heberle
Channelrhodopsins are light-gated ion channels with extensive applications in optogenetics. Channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) exhibits a red-shifted absorption spectrum as compared to Channelrhodopsin-2, which is highly beneficial for optogenetic application. The primary event in the photocycle of CaChR1 involves an isomerization of the protein-bound retinal chromophore. Here, we apply highly time-resolved vibronic spectroscopy to reveal the electronic and structural dynamics associated with the first step of the photocycle of CaChR1...
April 13, 2016: Journal of the American Chemical Society
Kathrin M Seibt, Torsten Wenke, Katja Muders, Bernd Truberg, Thomas Schmidt
Short interspersed nuclear elements (SINEs) are highly abundant non-autonomous retrotransposons that are widespread in plants. They are short in size, non-coding, show high sequence diversity, and are therefore mostly not or not correctly annotated in plant genome sequences. Hence, comparative studies on genomic SINE populations are rare. To explore the structural organization and impact of SINEs, we comparatively investigated the genome sequences of the Solanaceae species potato (Solanum tuberosum), tomato (Solanum lycopersicum), wild tomato (Solanum pennellii), and two pepper cultivars (Capsicum annuum)...
May 2016: Plant Journal: for Cell and Molecular Biology
Claudia Peitzsch, Monica Cojoc, Linda Hein, Ina Kurth, Katrin Mäbert, Franziska Trautmann, Barbara Klink, Evelin Schröck, Manfred P Wirth, Mechthild Krause, Eduard A Stakhovsky, Gennady D Telegeev, Vladimir Novotny, Marieta Toma, Michael Muders, Gustavo B Baretton, Fiona M Frame, Norman J Maitland, Michael Baumann, Anna Dubrovska
Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to a population of cancer stem cells (CSC) that survives radiotherapy, analysis of this cell population might illuminate tactics to personalize treatment. However, this direction remains challenging given the plastic nature of prostate cancers following treatment. We show here that irradiating prostate cancer cells stimulates a durable upregulation of stem cell markers that epigenetically reprogram these cells...
May 1, 2016: Cancer Research
Sebastian Muders
One of the widely recognized facts about human dignity is its vastly divergent applicability-from highly controversial issues in bioethics to broader topics in political philosophy. A group of theories that this article subsumes under the header "natural good theories" appears to be especially fitted for normatively multifaceted notions like dignity. However, the heavy normative weight the concept of dignity has to bear due to the central position it occupies within these theories creates its own difficulties...
April 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
Frank Josef Möller, Daniela Pemp, Sebastian T Soukup, Kathleen Wende, Xiajie Zhang, Oliver Zierau, Michael H Muders, Maarten C Bosland, Sabine E Kulling, Leane Lehmann, Günter Vollmer
There is an ongoing debate whether the intake of soy-derived isoflavones (sISO) mediates beneficial or adverse effects with regard to breast cancer risk. Therefore, we investigated whether nutritional exposure to a sISO-enriched diet from conception until adulthood impacts on 17β-estradiol (E2)-induced carcinogenesis in the rat mammary gland (MG). August-Copenhagen-Irish (ACI) rats were exposed to dietary sISO from conception until postnatal day 285. Silastic tubes containing E2 were used to induce MG tumorigenesis...
August 2016: Archives of Toxicology
Samikshan Dutta, Sohini Roy, Navatha S Polavaram, Marissa J Stanton, Heyu Zhang, Tanvi Bhola, Pia Hönscheid, Terrence M Donohue, Hamid Band, Surinder K Batra, Michael H Muders, Kaustubh Datta
Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor frequently overexpressed in various malignancies, where it has been implicated in promoting many protumorigenic behaviors, such as imparting therapeutic resistance to metastatic cancer cells. Here, we report a novel function of NRP2 as a regulator of endocytosis, which is enhanced in cancer cells and is often associated with increased metastatic potential and drug resistance. We found that NRP2 depletion in human prostate and pancreatic cancer cells resulted in the accumulation of EEA1/Rab5-positive early endosomes concomitant with a decrease in Rab7-positive late endosomes, suggesting a delay in early-to-late endosome maturation...
January 15, 2016: Cancer Research
Till Stensitzki, Vera Muders, Ramona Schlesinger, Joachim Heberle, Karsten Heyne
The primary photodynamics of channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by VIS-pump supercontinuum probe experiments from femtoseconds to 100 picoseconds. In contrast to reported experiments on channelrhodopsin-2 from Chlamydomonas reinhardtii (CrChR2), we found a clear dependence of the photoreaction dynamics on varying the excitation wavelength. Upon excitation at 500 and at 550 nm we detected different bleaching bands, and spectrally distinct photoproduct absorptions in the first picoseconds...
2015: Frontiers in Molecular Biosciences
U Guenther, F Koegl, N Theuerkauf, J Maylahn, U Andorfer, J Weykam, T Muders, C Putensen
BACKGROUND: Financial resources for the treatment of ICU patients requiring high nursing workload are allocated within the German diagnostic-related groups (DRG) system in part through the Therapeutic Intervention Scoring System-10 (TISS-10). TISS-10, however, has never been validated. This study evaluated whether delirium and agitation in ICU were reflected by TISS-10, and also by the established workload indices TISS-28 and Nine Equivalents of Nursing Manpower (NEMS). Secondary aims were if indices correlated, and what effects delirium and agitation had on financial balances...
February 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Athanasios Ziogas, Michael H Muders, Matina Economopoulou, David Sprott, Sylvia Grossklaus, Gabriele Siegert, Gustavo B Baretton, Ioannis Mitroulis, Triantafyllos Chavakis
OBJECTIVE: Endothelial cell activation by tumor necrosis factor (TNF) and associated leukocyte infiltration are hallmarks of vasculitis. The aim of this study was to investigate the potential role of the cellular stress-associated endothelial X-box binding protein 1 (XBP-1) transcription factor in TNF-induced endothelial cell inflammation and vasculitis. METHODS: Mice with an endothelial cell-specific XBP-1 deficiency were used in a modified local Shwartzman reaction (LSR) model of TNF-induced small vessel vasculitis...
December 2015: Arthritis & Rheumatology
Alicia Demirjian, Claressa E Lucas, Laurel E Garrison, Natalia A Kozak-Muiznieks, Stanley States, Ellen W Brown, Jonathan M Wortham, Amanda Beaudoin, Megan L Casey, Chandra Marriott, Alison M Ludwig, Ali F Sonel, Robert R Muder, Lauri A Hicks
BACKGROUND: Healthcare-associated Legionnaires' disease (LD) is a preventable pneumonia with a 30% case fatality rate. The Centers for Disease Control and Prevention guidelines recommend a high index of suspicion for the diagnosis of healthcare-associated LD. We characterized an outbreak and evaluated contributing factors in a hospital using copper-silver ionization for prevention of Legionella growth in water. METHODS: Through medical records review at a large, urban tertiary care hospital in November 2012, we identified patients diagnosed with LD during 2011-2012...
June 1, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Víctor A Lórenz-Fonfría, Vera Muders, Ramona Schlesinger, Joachim Heberle
Water plays an essential role in the structure and function of proteins, particularly in the less understood class of membrane proteins. As the first of its kind, channelrhodopsin is a light-gated cation channel and paved the way for the new and vibrant field of optogenetics, where nerve cells are activated by light. Still, the molecular mechanism of channelrhodopsin is not understood. Here, we applied time-resolved FT-IR difference spectroscopy to channelrhodopsin-1 from Chlamydomonas augustae. It is shown that the (conductive) P2(380) intermediate decays with τ ≈ 40 ms and 200 ms after pulsed excitation...
December 14, 2014: Journal of Chemical Physics
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