Sayantani Chatterjee, Ling Y Lee, Rebeca Kawahara, Jodie L Abrahams, Barbara Adamczyk, Merrina Anugraham, Christopher Ashwood, Zeynep Sumer-Bayraktar, Matthew T Briggs, Jenny H L Chik, Arun Everest-Dass, Sarah Förster, Hannes Hinneburg, Katia R M Leite, Ian Loke, Uwe Möginger, Edward S X Moh, Miyako Nakano, Saulo Recuero, Manveen K Sethi, Miguel Srougi, Kathrin Stavenhagen, Vignesh Venkatakrishnan, Katherine Wongtrakul-Kish, Simone Diestel, Peter Hoffmann, Niclas G Karlsson, Daniel Kolarich, Mark P Molloy, Michael H Muders, Martin K Oehler, Nicolle H Packer, Giuseppe Palmisano, Morten Thaysen-Andersen
While aberrant protein glycosylation is a recognised characteristic of human cancers, advances in glycoanalytics continue to discover new associations between glycoproteins and tumourigenesis. This glycomics-centric study investigates a possible link between protein paucimannosylation, an under-studied class of human N-glycosylation [Man1-3 GlcNAc2 Fuc0-1 ], and human cancers. The paucimannosidic glycans (PMGs) of 34 cancer cell lines and 133 tissue samples spanning 11 cancer types and matching non-cancerous specimens were profiled from 467 published and unpublished PGC-LC-MS/MS N-glycome datasets collected over a decade within our laboratories...
August 16, 2019: Proteomics