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Claudia Peitzsch, Monica Cojoc, Linda Hein, Ina Kurth, Katrin Mäbert, Franziska Trautmann, Barbara Klink, Evelin Schröck, Manfred P Wirth, Mechthild Krause, Eduard A Stakhovsky, Gennady D Telegeev, Vladimir Novotny, Marieta Toma, Michael Muders, Gustavo B Baretton, Fiona M Frame, Norman J Maitland, Michael Baumann, Anna Dubrovska
Radiotherapy is a mainstay of curative prostate cancer treatment, but risks of recurrence after treatment remain significant in locally advanced disease. Given that tumor relapse can be attributed to a population of cancer stem cells (CSC) that survives radiotherapy, analysis of this cell population might illuminate tactics to personalize treatment. However, this direction remains challenging given the plastic nature of prostate cancers following treatment. We show here that irradiating prostate cancer cells stimulates a durable upregulation of stem cell markers that epigenetically reprogram these cells...
May 1, 2016: Cancer Research
Samikshan Dutta, Sohini Roy, Navatha S Polavaram, Marissa J Stanton, Heyu Zhang, Tanvi Bhola, Pia Hönscheid, Terrence M Donohue, Hamid Band, Surinder K Batra, Michael H Muders, Kaustubh Datta
Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor frequently overexpressed in various malignancies, where it has been implicated in promoting many protumorigenic behaviors, such as imparting therapeutic resistance to metastatic cancer cells. Here, we report a novel function of NRP2 as a regulator of endocytosis, which is enhanced in cancer cells and is often associated with increased metastatic potential and drug resistance. We found that NRP2 depletion in human prostate and pancreatic cancer cells resulted in the accumulation of EEA1/Rab5-positive early endosomes concomitant with a decrease in Rab7-positive late endosomes, suggesting a delay in early-to-late endosome maturation...
January 15, 2016: Cancer Research
Alicia Demirjian, Claressa E Lucas, Laurel E Garrison, Natalia A Kozak-Muiznieks, Stanley States, Ellen W Brown, Jonathan M Wortham, Amanda Beaudoin, Megan L Casey, Chandra Marriott, Alison M Ludwig, Ali F Sonel, Robert R Muder, Lauri A Hicks
BACKGROUND: Healthcare-associated Legionnaires' disease (LD) is a preventable pneumonia with a 30% case fatality rate. The Centers for Disease Control and Prevention guidelines recommend a high index of suspicion for the diagnosis of healthcare-associated LD. We characterized an outbreak and evaluated contributing factors in a hospital using copper-silver ionization for prevention of Legionella growth in water. METHODS: Through medical records review at a large, urban tertiary care hospital in November 2012, we identified patients diagnosed with LD during 2011-2012...
June 1, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Torsten Wenke, Kathrin M Seibt, Thomas Döbel, Katja Muders, Thomas Schmidt
The unambiguous differentiation of crop genotypes is often laborious or expensive. A rapid, robust, and cost-efficient marker system is required for routine genotyping in plant breeding and marker-assisted selection. We describe the Inter-SINE Amplified Polymorphism (ISAP) system that is based on standard molecular methods resulting in genotype-specific fingerprints at high resolution. These markers are derived from Short Interspersed Nuclear Elements (SINEs) which are dispersed repetitive sequences present in most if not all plant genomes and can be efficiently extracted from plant genome sequences...
2015: Methods in Molecular Biology
K Krüger, C Pilat, M Schild, N Lindner, T Frech, K Muders, F C Mooren
Different types of exercise are characterized by the ability to induce specific physiological stimuli that might be able to induce the mobilization of progenitor cells. The aim of the current study was to investigate the mobilization of hematopoietic progenitor cells (HPCs) and endothelial progenitor cells (EPCs) in response to endurance, resistance, and eccentric endurance exercise and their relation to markers of muscle damage and inflammation. Healthy male subjects performed acute bouts of either endurance exercise, resistance exercise, or eccentric endurance exercise...
June 2015: Scandinavian Journal of Medicine & Science in Sports
Ashima Singh, Sarah M Bartsch, Robert R Muder, Bruce Y Lee
BACKGROUND: While the persistence of high surgical site infection (SSI) rates has prompted the advent of more expensive sutures that are coated with antimicrobial agents to prevent SSIs, the economic value of such sutures has yet to be determined. METHODS: Using TreeAge Pro, we developed a decision analytic model to determine the cost-effectiveness of using antimicrobial sutures in abdominal incisions from the hospital, third-party payer, and societal perspectives...
August 2014: Infection Control and Hospital Epidemiology
B Keck, S Wach, H Taubert, S Zeiler, O J Ott, F Kunath, A Hartmann, S Bertz, C Weiss, P Hönscheid, S Schellenburg, C Rödel, G B Baretton, R Sauer, R Fietkau, B Wullich, F S Krause, K Datta, M H Muders
The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in therapy resistance. Therefore, we studied the prognostic impact of NRP2 and VEGF-C in 247 bladder cancer patients (cN0M0) treated with TURBT and RCT (n = 198) or RT (n = 49) and a follow-up time up to 15 years...
January 15, 2015: International Journal of Cancer. Journal International du Cancer
M Stier, S Muders, M Rüther, B Schöne-Seifert
Current biological psychiatry, it is frequently claimed by its opponents, is "biologistic" and unduly narrows psychological disorders to neurobiology and molecular biology. They deem a complete neuroscientific reduction of the mental phenomena to be impossible because of the impossibility of reducing certain phenomena, such as the individual subjective experience. If such a reduction is nevertheless undertaken it is ultimately to the disadvantage of the patients. We argue in this article that the very term "biologism" has to be put under scrutiny in the first place...
October 2013: Der Nervenarzt
Yuriko Fukuta, Robert R Muder, Mounzer E Agha, Lloyd G Clarke, Marilyn M Wagener, Amelia M Hensler, Yohei Doi
BACKGROUND: Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited. METHODS: We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii. RESULTS: A total of 31 case patients were matched with 62 control patients...
December 2013: American Journal of Infection Control
Kristin Franke, Joanna Kalucka, Soulafa Mamlouk, Rashim Pal Singh, Antje Muschter, Alexander Weidemann, Vasuprada Iyengar, Steffen Jahn, Kathrin Wieczorek, Kathrin Geiger, Michael Muders, Alex M Sykes, David M Poitz, Tatsiana Ripich, Teresa Otto, Sybille Bergmann, Georg Breier, Gustavo Baretton, Guo-Hua Fong, David R Greaves, Stefan Bornstein, Triantafyllos Chavakis, Joachim Fandrey, Max Gassmann, Ben Wielockx
Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible factor (HIF). Accumulating evidence suggests that oxygen-sensitive prolyl hydroxylases (PHDs) are important regulators of this entire system. Here, we describe a novel mouse line with conditional PHD2 inactivation (cKO P2) in renal EPO producing cells, neurons, and astrocytes that displayed excessive erythrocytosis because of severe overproduction of EPO, exclusively driven by HIF-2α...
February 21, 2013: Blood
Judith A Gilbert, Laura J Adhikari, Ricardo V Lloyd, Thorvardur R Halfdanarson, Michael H Muders, Matthew M Ames
OBJECTIVES: Pancreatic endocrine tumors (PETs) share numerous features with gastrointestinal neuroendocrine (carcinoid) tumors. Targets of novel therapeutic strategies previously assessed in carcinoid tumors were analyzed in PETs (44 cases). METHODS: Activating mutations in EGFR, KIT, and PDGFRA and nonresponse mutations in KRAS were evaluated. Copy number of EGFR and HER-2/neu was quantified by fluorescence in situ hybridization. Expression of EGFR, PDGFRA, VEGFR1, TGFBR1, Hsp90, SSTR2A, SSTR5, IGF1R, mTOR, and MGMT was measured immunohistochemically...
April 2013: Pancreas
Yuriko Fukuta, Candace A Cunningham, Patricia L Harris, Marilyn M Wagener, Robert R Muder
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen in hospital-acquired infections. MRSA-colonized inpatients who may benefit from undergoing decolonization have not been identified. OBJECTIVE: To identify risk factors for MRSA infection among patients who are colonized with MRSA at hospital admission. DESIGN: A case-control study. SETTING: A 146-bed Veterans Affairs hospital. PARTICIPANTS: Case patients were those patients admitted from January 2003 to August 2011 who were found to be colonized with MRSA on admission and then developed MRSA infection...
December 2012: Infection Control and Hospital Epidemiology
A Singer, Y Deuse, U Koch, T Hölscher, D Pfitzmann, C Jakob, S Hehlgans, G B Baretton, A Rentsch, M Baumann, M H Muders, M Krause
PURPOSE: Studies have shown that GIPC1/Synectin is an essential adaptor protein of receptors that play an important role in cancer progression and therapy resistance. This is the first study to explore the role of GIPC1/Synectin in radioresistance of prostate cancer and as a possible predictive marker for outcome of primary radiation therapy. MATERIALS AND METHODS: The effect of RNA interference-mediated GIPC1/Synectin depletion on clonogenic cell survival after irradiation with 0, 2, 4, or 6 Gy was assayed in two different GIPC1/Synectin-expressing human prostate cancer cell lines...
December 2012: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Yeohan Song, Julie H Y Tai, Sarah M Bartsch, Richard K Zimmerman, Robert R Muder, Bruce Y Lee
Staphylococcus aureus infections are a substantial problem for hemodialysis patients. Several vaccine candidates are currently under development, with hemodialysis patients being one possible target population. To determine the potential economic value of an S. aureus vaccine among hemodialysis patients, we developed a Markov decision analytic computer simulation model. When S. aureus colonization prevalence was 1%, the incremental cost-effectiveness ratio (ICER) of vaccination was ≤$25,217/quality-adjusted life year (QALY)...
May 21, 2012: Vaccine
Kathrin M Seibt, Torsten Wenke, Cora Wollrab, Holger Junghans, Katja Muders, Klaus J Dehmer, Kerstin Diekmann, Thomas Schmidt
Potato variety discrimination based on morphological traits is laborious and influenced by the environment, while currently applied molecular markers are either expensive or time-consuming in development or application. SINEs, short interspersed nuclear elements, are retrotransposons with a high copy number in plant genomes representing a potential source for new markers. We developed a marker system for potato genotyping, designated inter-SINE amplified polymorphism (ISAP). Based on nine potato SINE families recently characterized (Wenke et al...
June 2012: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
C Jilek, J Gebauer, F Muders, M Arzt, G Riegger, M Pfeifer, R Wensel
BACKGROUND: Repetitive nocturnal sympathetic activation during episodes of apnea and postapneic hyperventilation increases cardiovascular risk. The effects of hypopnea and non-apneic, non-hypopneic intervals before and after hypopnea/apnea on sympathico-vagal balance have not been assessed yet. HYPOTHESIS: Hypopnea and non-apneic, non-hypopneic intervals before and after hypopnea/apnea cause increased sympathetic activity when compared to normal respiration in nonREM stages 2–4...
March 2012: Herzschrittmachertherapie & Elektrophysiologie
D Schwan, P A R Ade, K Basu, A N Bender, F Bertoldi, H-M Cho, G Chon, John Clarke, M Dobbs, D Ferrusca, R Güsten, N W Halverson, W L Holzapfel, C Horellou, D Johansson, B R Johnson, J Kennedy, Z Kermish, R Kneissl, T Lanting, A T Lee, M Lueker, J Mehl, K M Menten, D Muders, F Pacaud, T Plagge, C L Reichardt, P L Richards, R Schaaf, P Schilke, M W Sommer, H Spieler, C Tucker, A Weiss, B Westbrook, O Zahn
The Atacama pathfinder experiment Sunyaev-Zel'dovich (APEX-SZ) instrument is a millimeter-wave cryogenic receiver designed to observe galaxy clusters via the Sunyaev-Zel'dovich effect from the 12 m APEX telescope on the Atacama plateau in Chile. The receiver contains a focal plane of 280 superconducting transition-edge sensor (TES) bolometers instrumented with a frequency-domain multiplexed readout system. The bolometers are cooled to 280 mK via a three-stage helium sorption refrigerator and a mechanical pulse-tube cooler...
September 2011: Review of Scientific Instruments
S M McGlone, R R Bailey, S M Zimmer, M J Popovich, Y Tian, P Ufberg, R R Muder, B Y Lee
Although Clostridium difficile (C. difficile) is the leading cause of infectious diarrhoea in hospitalized patients, the economic burden of this major nosocomial pathogen for hospitals, third-party payers and society remains unclear. We developed an economic computer simulation model to determine the costs attributable to healthcare-acquired C. difficile infection (CDI) from the hospital, third-party payer and societal perspectives. Sensitivity analyses explored the effects of varying the cost of hospitalization, C...
March 2012: Clinical Microbiology and Infection
B Y Lee, Y Song, S M McGlone, R R Bailey, J M Feura, J H Y Tai, G J Lewis, A E Wiringa, K J Smith, R R Muder, L H Harrison, B Piraino
Methicillin-resistant Staphylococcus aureus (MRSA) can cause severe infections in patients undergoing haemodialysis. Routine periodic testing of haemodialysis patients and attempting to decolonize those who test positive may be a strategy to prevent MRSA infections. The economic value of such a strategy has not yet been estimated. We constructed a Markov computer simulation model to evaluate the economic value of employing routine testing (agar-based or PCR) at different MRSA prevalence, spontaneous clearance, costs of decolonization and decolonization success rates, performed every 3, 6 or 12 months...
November 2011: Clinical Microbiology and Infection
Rachel R Bailey, Dianna R Stuckey, Bryan A Norman, Andrew P Duggan, Kristina M Bacon, Diana L Connor, Ingi Lee, Robert R Muder, Bruce Y Lee
OBJECTIVE: To estimate the economic value of dispensing preoperative home-based chlorhexidine bathing cloth kits to orthopedic patients to prevent surgical site infection (SSI). METHODS: A stochastic decision-analytic computer simulation model was developed from the hospital's perspective depicting the decision of whether to dispense the kits preoperatively to orthopedic patients. We varied patient age, cloth cost, SSI-attributable excess length of stay, cost per bed-day, patient compliance with the regimen, and cloth antimicrobial efficacy to determine which variables were the most significant drivers of the model's outcomes...
May 2011: Infection Control and Hospital Epidemiology
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