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https://www.readbyqxmd.com/read/28734685/r-scan-cardiac-ct-angiography-for-acute-chest-pain
#1
Pamela K Woodard, Sebastian R McWilliams, Demetrios A Raptis, Judd E Hollander, Harold I Litt, Todd C Villines, Quynh A Truong
No abstract text is available yet for this article.
July 20, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28717030/intestinal-epithelial-ecto-5-nucleotidase-cd73-regulates-intestinal-colonization-and-infection-by-nontyphoidal-salmonella
#2
Daniel J Kao, Bejan J Saeedi, David Kitzenberg, Krista M Burney, Evgenia Dobrinskikh, Kayla D Battista, Andrés Vázquez-Torres, Sean P Colgan, Douglas J Kominsky
Ecto-5' -nucleotidase (CD73) is expressed abundantly on the apical surface of intestinal epithelial cells (IEC) and functions as the terminal enzyme in the generation of extracellular adenosine. Previous work has demonstrated that adenosine signaling in IECs results in a number of tissue-protective effects during inflammation; however, a rationale for its apical expression has been lacking. We hypothesized that the highly polarized expression of CD73 is indicative of an important role for extracellular adenosine as a mediator of host-microbe interactions...
July 17, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28711941/combination-of-cadherin-17-and-satb-homeobox-2-serves-as-potential-optimal-makers-for-the-differential-diagnosis-of-pulmonary-enteric-adenocarcinoma-and-metastatic-colorectal-adenocarcinoma
#3
Tingting Bian, Jinli Zhao, Jia Feng, Qing Zhang, Li Qian, Jian Liu, Daishan Jiang, Yifei Liu, Jianguo Zhang
BACKGROUND: Pulmonary enteric adenocarcinoma (PEAC), a rare type of non-small cell lung cancer, has similar histological and immunohistochemical morphology to colorectal adenocarcinoma. Cadherin-17 (CDH17) and SATB homeobox 2 (SATB2) immunoexpression have recently been demonstrated in colorectal adenocarcinoma. In this study, we evaluated the value of CDH17 and SATB2 in the diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. METHODS: A total of 13 PEAC cases and 27 metastatic colorectal adenocarcinoma cases were enrolled in our cohort study...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704336/plasmatic-villin-1-is-a-novel-in-vivo-marker-of-proximal-tubular-cell-injury-during-renal-ischemia-reperfusion
#4
Jean-Paul Decuypere, Laurens J Ceulemans, Tine Wylin, Martinet Wim, Diethard Monbaliu, Jacques Pirenne, Ina Jochmans
BACKGROUND: Early detection of acute kidney injury (AKI), a common condition with a high mortality risk, can be facilitated by specific and reliable biomarkers. Villin 1, a protein typically found in the brush borders of proximal tubular cells, has been detected in urine of patients with AKI, but its possible release in plasma remains unexplored. METHODS: We measured the presence of villin 1 by immunohistochemistry on kidney sections and by Western blotting in plasma samples from rats subjected to renal ischemia-reperfusion injury, pigs subjected to renal transplantation and liver transplantation patients that developed AKI...
July 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28647813/ghvln4-is-involved-in-cell-elongation-via-regulation-of-actin-organization
#5
Fenni Lv, Mingya Han, Dongdong Ge, Hui Dong, Xiaotong Zhang, Lifeng Li, Peipei Zhang, Zhongqi Zhang, Jing Sun, Kang Liu, Youlu Yuan
GhVLN4 exhibited activity of cross-linking actin filaments into bundles. Overexpression of GhVLN4 increased the abundance of thick actin bundles and resulted in longer cell phenotypes. Actin bundle is a dynamic, higher-order cytoskeleton structure that is essential for cell expansion. Villin is one of the major proteins responsible for crosslinking actin filaments into bundles. However, this kind of actin binding protein has rarely been investigated in cotton. In the present work, a cotton villin gene was molecularly cloned from Upland cotton and denominated as GhVLN4...
June 24, 2017: Planta
https://www.readbyqxmd.com/read/28628120/intestinal-cancer-progression-by-mutant-p53-through-the-acquisition-of-invasiveness-associated-with-complex-glandular-formation
#6
M Nakayama, E Sakai, K Echizen, Y Yamada, H Oshima, T-S Han, R Ohki, S Fujii, A Ochiai, S Robine, D C Voon, T Tanaka, M M Taketo, M Oshima
Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated Apc(Δ716) Trp53(LSL•R270H) villin-CreER compound mice, in which mutant p53(R270H) was expressed in the intestinal epithelia upon tamoxifen treatment, and examined the intestinal tumor phenotypes and tumor-derived organoids...
June 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28607128/relationship-of-hypertension-to-coronary-atherosclerosis-and-cardiac-events-in-patients-with-coronary-computed-tomographic-angiography
#7
Rine Nakanishi, Lohendran Baskaran, Heidi Gransar, Matthew J Budoff, Stephan Achenbach, Mouaz Al-Mallah, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Ricardo Cury, Gudrun Feuchtner, Yong-Jin Kim, Jonathon Leipsic, Philipp A Kaufmann, Erica Maffei, Gilbert Raff, Leslee J Shaw, Todd C Villines, Allison Dunning, Hugo Marques, Gianluca Pontone, Daniele Andreini, Ronen Rubinshtein, Jeroen Bax, Erica Jones, Niree Hindoyan, Millie Gomez, Fay Y Lin, James K Min, Daniel S Berman
Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease...
August 2017: Hypertension
https://www.readbyqxmd.com/read/28591806/quantitative-proteomics-of-intestinal-mucosa-from-male-mice-lacking-intestinal-epithelial-insulin-receptors
#8
Stina Rikke Jensen, Erwin M Schoof, Sarah E Wheeler, Henning Hvid, Jonas Ahnfelt-Rønne, Bo Falck Hansen, Erica Nishimura, Grith Skytte Olsen, Thomas Kislinger, Patricia L Brubaker
The goal of the present study was to determine whether loss of the insulin receptor alters the molecular landscape of the intestinal mucosa, using intestinal-epithelial insulin receptor knockout (IE-irKO) mice and both genetic (IRfl/fl and Villin-cre) controls. Quantitative proteomic analysis by Liquid Chromatography Mass Spectrometry (LC-MS) was applied to jejunal and colonic mucosa from mice fed a chow- or Western diet (WD). Jejunal mucosa from IE-irKO mice demonstrated alterations in all intestinal cell linages, Paneth, goblet, absorptive and enteroendocrine cells, whereas only goblet and absorptive cells were affected in the colon...
June 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/28582340/a-report-of-ovarian-sertoli-leydig-cell-tumors-with-heterologous-intestinal-type-glands-and-alpha-fetoprotein-elevation-and-review-of-the-literature
#9
Maysa Al-Hussaini, Yazan Al-Othman, Eman Hijazi, W Glenn McCluggage
Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon neoplasms that are occasionally associated with an elevated level of serum alpha fetoprotein (AFP), a marker of germ cell neoplasms, particularly yolk sac tumor (YST). We report 7 cases of ovarian SLCT (3 moderately differentiated, 2 poorly differentiated, 2 retiform) with heterologous intestinal-type glands, 6 of which were associated with elevated serum AFP. The intestinal-type mucinous glands were immunoreactive for SALL4 (4 cases), AFP (4 cases), glypican 3 (1 case), CDX2 (6 cases), and villin (7 cases), markers that are commonly expressed in YSTs, although the latter 2 markers would be expected to be positive in intestinal-type glands...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28579389/scct-president-s-page-2017-a-very-productive-year-setting-the-stage-for-future-success
#10
EDITORIAL
Leslee J Shaw, Todd C Villines
No abstract text is available yet for this article.
July 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28575164/genetic-mouse-models-with-intestinal-specific-tight-junction-deletion-resemble-an-ulcerative-colitis-phenotype
#11
Wolfgang Stremmel, Simone Staffer, Mathias Jochen Schneider, Hongying Gan-Schreier, Andreas Wannhoff, Nicole Stuhrmann, Annika Gauss, Hartwig Wolburg, Anne Mahringer, Alexander Swidsinski, Thomas Efferth
Background and Aims: A key pathogenetic feature of ulcerative colitis(UC) is an intrinsic low mucus phosphatidylcholine(PC) content. Recently, a paracellular transport for PC across tight junctions(TJ) was described, suggesting TJ disturbance as cause of diminished luminal PC transport. Therefore we aimed to generate mutant mice with TJ deletion to evaluate whether an UC phenotype developed. Methods: CL57BL/6 control wild-type mice were compared to mutant mice with tamoxifen-induced villin-Cre dependent intestinal deletion of kindlin 1 and 2...
May 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28556957/increased-frequency-of-bronchiolar-histotypes-in-lung-carcinomas-associated-with-idiopathic-pulmonary-fibrosis
#12
Anna Caliò, Veronica Lever, Andrea Rossi, Eliana Gilioli, Matteo Brunelli, Alessandra Dubini, Sara Tomassetti, Sara Piciucchi, Alessia Nottegar, Giulio Rossi, Marianne Kambouchner, Alessandra Cancellieri, Mattia Barbareschi, Giuseppe Pelosi, Claudio Doglioni, Alberto Cavazza, Rodolfo Carella, Paolo Graziano, Bruno Murer, Venerino Poletti, Marco Chilosi
AIMS: The association between lung cancer and idiopathic pulmonary fibrosis (IPF) is well-known, however the significance of this association is poorly understood. Bronchiolar honeycomb cysts have been proposed as possible precursors for development of carcinoma, but limited evidence of this hypothesis is available. METHODS AND RESULTS: Thirty-three lung carcinomas arising in patients with IPF have been analyzed using a panel of immunohistochemical markers. The antibodies included pneumocyte markers (TTF1, Napsin-A, SPA1), the goblet cell marker MUC5AC, markers of basal/squamous cell differentiation (CK5/6, ΔN-p63) and markers related to enteric differentiation (CDX2, MUC2, CK20, villin)...
May 30, 2017: Histopathology
https://www.readbyqxmd.com/read/28552621/intestinal-epithelial-sirtuin-1-regulates-intestinal-inflammation-during-aging-in-mice-by-altering-the-intestinal-microbiota
#13
Alicia S Wellman, Mallikarjuna R Metukuri, Nevzat Kazgan, Xiaojiang Xu, Qing Xu, Natalie S X Ren, Agnieszka Czopik, Michael T Shanahan, Ashley Kang, Willa Chen, M Andrea Azcarate-Peril, Ajay S Gulati, David C Fargo, Leonard Guarente, Xiaoling Li
BACKGROUND & AIMS: Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD), but the mechanisms of this process are not clear. We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-dependent protein deacetylase, senses environmental stress to alter intestinal integrity. METHODS: We performed studies of mice with disruption of Sirt1 specifically in the intestinal epithelium (SIRT1 iKO, villin-Cre+, Sirt1(flox/flox) mice) and control mice (villin-Cre-, Sirt1(flox/flox)) on a C57BL/6 background...
May 26, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28541151/morphological-evaluation-of-merkel-cells-and-small-lamellated-sensory-receptors-in-the-equine-foot
#14
Robert M Bowker, Lisa S Lancaster, Diane A Isbell
OBJECTIVE To examine the equine foot for the presence of sensory receptors including Merkel cells and small lamellated Pacinian-like corpuscles (SLPCs). SAMPLE Forefeet obtained from 7 horses following euthanasia for reasons other than foot disease. PROCEDURES Disarticulated feet were cut into either sagittal sections or cross sections and immersed in neutral-buffered 4% formalin. Following fixation, samples were obtained from the midline of the dorsal aspect of the hoof wall and from the frog (cuneus ungulae) between the apex and central sulcus...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28473526/modeling-renal-cell-carcinoma-in-mice-bap1-and-pbrm1-inactivation-drive-tumor-grade
#15
Yi-Feng Gu, Shannon Cohn, Alana Christie, Tiffani McKenzie, Nicholas C Wolff, Quyen N Do, Ananth Madhuranthakam, Ivan Pedrosa, Tao Wang, Anwesha Dey, Meinrad Busslinger, Xian-Jin Xie, Robert E Hammer, Renée M McKay, Payal Kapur, James Brugarolas
Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutation, which are associated with tumors of different grade and prognosis. However, whether BAP1 and PBRM1 loss causes ccRCC and determines tumor grade is unclear. We conditionally targeted Bap1 and Pbrm1 (with Vhl) in the mouse using several Cre drivers. Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of ccRCC origins. In contrast, targeting with Pax8, a developmental lineage-specific transcription factor, led to ccRCC of different grade...
May 4, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28470013/pyogenic-pericarditis-and-cardiac-tamponade-due-to-streptococcus-anginosus-in-a-combat-theater
#16
Ryan C Maves, Michael S Tripp, Tracy Franzos, Scott C Wallace, Benjamin J Drinkwine, Todd C Villines
Streptococcus anginosus group pericarditis is rare. A 24-year-old male soldier presented for care at a military clinic in Afghanistan with shock and cardiac tamponade requiring emergent pericardial drainage and aeromedical evacuation. We review the patient's case, the need for serial pericardial drainage, and the available literature on this disorder.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28452892/re-comparison-of-nonoperative-and-surgical-management-of-renal-trauma
#17
Marc A Bjurlin, Richard Jacob Fantus, Richard Joseph Fantus, Dana Villines
No abstract text is available yet for this article.
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422069/protein-stability-and-unfolding-following-glycine-radical-formation
#18
Michael C Owen, Imre G Csizmadia, Béla Viskolcz, Birgit Strodel
Glycine (Gly) residues are particularly susceptible to hydrogen abstraction; which results in the formation of the capto-dative stabilized Cα-centered Gly radical (GLR) on the protein backbone. We examined the effect of GLR formation on the structure of the Trp cage; tryptophan zipper; and the villin headpiece; three fast-folding and stable miniproteins; using all-atom (OPLS-AA) molecular dynamics simulations. Radicalization changes the conformation of the GLR residue and affects both neighboring residues but did not affect the stability of the Trp zipper...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28385693/expression-and-localization-of-vpac1-the-major-receptor-of-vasoactive-intestinal-peptide-along-the-length-of-the-intestine
#19
Dulari Jayawardena, Grace Guzman, Ravinder K Gill, Waddah A Alrefai, Hayat Onyuksel, Pradeep K Dudeja
Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide with a broad array of physiological functions in many organs including the intestine. Its actions are mediated via G protein-coupled receptors, and vasoactive intestinal peptide receptor 1 (VPAC1) is the key receptor responsible for majority of VIP's biological activity. The distribution of VPAC1 along the length of the gastrointestinal tract and its subcellular localization in intestinal epithelial cells have not been fully characterized. The current studies were undertaken to determine VPAC1 distribution and localization so that VIP-based therapies can be targeted to specific regions of the intestine...
July 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28385391/prognostic-implications-of-coronary-artery-calcium-in-the-absence-of-coronary-artery-luminal-narrowing
#20
Iksung Cho, Bríain Ó Hartaigh, Heidi Gransar, Valentina Valenti, Fay Y Lin, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J W Chow, Allison M Dunning, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathon Leipsic, Leslee J Shaw, Philipp A Kaufmann, Ricardo C Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, James K Min
BACKGROUND AND AIMS: Coronary artery calcium (CAC) scoring is a predictor of future adverse clinical events, and a surrogate measure of overall coronary artery plaque burden. Coronary computed tomographic angiography (CCTA) is a contrast-enhanced method that allows for visualization of plaque as well as whether that plaque causes luminal narrowing. To date, the prognosis of individuals with CAC but without stenosis has not been reported. We explored the prevalence of CAC>0 and its prognostic utility for future mortality for patients without luminal narrowing by CCTA...
July 2017: Atherosclerosis
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