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https://www.readbyqxmd.com/read/29902643/a-rare-case-of-hyperplastic-proximal-esophageal-polyps-with-foveolar-dysplasia
#1
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29797058/prognostic-value-of-age-adjusted-segment-involvement-score-as-measured-by-coronary-computed-tomography-a-potential-marker-of-vascular-age
#2
Chadi Ayoub, Leonard Kritharides, Yeung Yam, Li Chen, Alomgir Hossain, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Ricardo C Cury, Augustin Delago, Allison Dunning, Gudrun Feuchtner, Millie Gomez, Heidi Gransar, Martin Hadamitzky, Joerg Hausleiter, Niree Hindoyan, Philipp A Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, James K Min, Benjamin J W Chow
Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study...
May 24, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29790602/folding-with-a-protein-s-native-shortcut-network
#3
Susan Khor
A complex network approach to protein folding is proposed, wherein a protein's contact map is re-conceptualized as a network of shortcut edges, and folding is steered by a structural characteristic of this network. Shortcut networks are generated by a known message passing algorithm operating on protein residue networks. It is found that the shortcut networks of native structures (SCN0s) are relevant graph objects with which to study protein folding at a formal level. The logarithm form of their contact order (SCN0_lnCO) correlates significantly with folding rate of two-state and non-two-state proteins...
May 23, 2018: Proteins
https://www.readbyqxmd.com/read/29789376/optogenetic-activation-of-colon-epithelium-of-the-mouse-produces-high-frequency-bursting-in-extrinsic-colon-afferents-and-engages-visceromotor-responses
#4
Payal A Makadia, Sarah A Najjar, Jami L Saloman, Peter Adelman, Bin Feng, Joseph F Margiotta, Kathryn M Albers, Brian M Davis
Epithelial cells of the colon provide a vital interface between the internal environment (lumen of the colon) and colon parenchyma. To examine epithelial-neuronal signaling at this interface, we analyzed mice in which channelrhodopsin (ChR2) was targeted to either TRPV1-positive afferents or to villin expressing colon epithelial cells. Expression of a ChR2-EYFP fusion protein was directed to either primary sensory neurons or to colon epithelial cells by crossing Ai32 mice with TRPV1-Cre or villin-Cre mice, respectively...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29772553/establishment-of-a-porcine-model-of-indomethacin-induced-intestinal-injury
#5
Dan Yi, Wenkai Liu, Yongqing Hou, Lei Wang, Di Zhao, Tao Wu, Binying Ding, Guoyao Wu
A useful animal model of intestinal injury is pivotal for studying its pathogenesis and developing nutritional interventions (e.g., amino acid supplementation). Here, we propose the use of indomethacin (IDMT) to induce intestinal inflammation in neonatal pigs. Fourteen-day-old piglets fed a milk replacer diet receive intraperitoneal administration of IDMT (5 mg/kg body weight) for 3 consecutive days. On day 4, blood and intestinal samples are obtained for physiological and biochemical analyses. IDMT increases blood DAO activity, I-FABP concentration, neutrophil and eosinophil numbers; intestinal MMP3 mRNA levels, MPO activity, and MDA concentration; but reduces the plasma concentration of citrulline (synthesized exclusively by enterocytes of the small intestine), intestinal GSH-Px activity, and mRNA levels for villin , I-FABP , TRPV6 , AQP10 , and KCNJ13 ...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29766313/correction-to-long-term-prognostic-value-of-coronary-computed-tomography-angiography
#6
Takor B Arrey-Mbi, Seth M Klusewitz, Todd C Villines
The authors would like to note that this article published in Current Treatment Options in Cardiovascular Medicine journal is not showing Open Access on the website. Thus, the paper is still not available for free online.
May 16, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29759895/cardiovascular-computed-tomographic-angiography-entering-into-the-5th-stage
#7
EDITORIAL
James K Min, Gudrun M Feuchtner, Todd C Villines
No abstract text is available yet for this article.
May 5, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29753765/maximization-of-the-usage-of-coronary-cta-derived-plaque-information-using-a-machine-learning-based-algorithm-to-improve-risk-stratification-insights-from-the-confirm-registry
#8
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29753764/scct-advocacy-in-2018-progress-towards-improving-patient-access-to-imaging-care
#9
EDITORIAL
Todd C Villines
No abstract text is available yet for this article.
May 5, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29747947/myocardium-in-jeopardy-the-hemodynamic-implications-of-stenosis-proximity-and-severity-on-coronary-cta
#10
EDITORIAL
Todd C Villines
No abstract text is available yet for this article.
May 3, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29740018/examining-a-thermodynamic-order-parameter-of-protein-folding
#11
Song-Ho Chong, Sihyun Ham
Dimensionality reduction with a suitable choice of order parameters or reaction coordinates is commonly used for analyzing high-dimensional time-series data generated by atomistic biomolecular simulations. So far, geometric order parameters, such as the root mean square deviation, fraction of native amino acid contacts, and collective coordinates that best characterize rare or large conformational transitions, have been prevailing in protein folding studies. Here, we show that the solvent-averaged effective energy, which is a thermodynamic quantity but unambiguously defined for individual protein conformations, serves as a good order parameter of protein folding...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736317/klf5-mediates-the-hyper-proliferative-phenotype-of-the-intestinal-epithelium-in-mice-with-intestine-specific-endogenous-k-ras-g12d-expression
#12
Mandayam O Nandan, Agnieszka B Bialkowska, Vincent W Yang
Oncogenic K-Ras activation is a common mutational event in colorectal cancer. We previously showed that transcription factor, Krüppel-like factor 5 (KLF5), contributes to intestinal polyposis in mice with K-Ras activation. At 14 months of age, Villin-Cre/LSL-K-RasG12D mice developed small intestinal and colonic hyperplastic polyps while LSL-K-RasG12D had none. The intestinal crypts of Villin-Cre/LSL-K-RasG12D mice contained a higher number of mitotic figures and increased crypt heights compared to controls...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29693599/dietary-supplementation-with-oleum-cinnamomi-improves-intestinal-functions-in-piglets
#13
Dan Yi, Qiuhong Fang, Yongqing Hou, Lei Wang, Haiwang Xu, Tao Wu, Joshua Gong, Guoyao Wu
The present study was to determine the efficacy of dietary supplementation with oleum cinnamomi (OCM) on growth performance and intestinal functions in piglets. Sixteen piglets (24-day-old) were randomly assigned to the control or OCM groups. Piglets in the control group were fed a basal diet, whereas piglets in the OCM group were fed the basal diet supplemented with 50 mg/kg OCM. On day 20 of the trial, blood samples and intestinal tissues were obtained from piglets. Compared with the control group, dietary OCM supplementation increased ( p < 0...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29667891/diagnostic-performance-of-a-novel-coronary-ct-angiography-algorithm-prospective-multicenter-validation-of-an-intracycle-ct-motion-correction-algorithm-for-diagnostic-accuracy
#14
Daniele Andreini, Fay Y Lin, Asim Rizvi, Iksung Cho, Ran Heo, Gianluca Pontone, Antonio L Bartorelli, Saima Mushtaq, Todd C Villines, Patricia Carrascosa, Byoung Wook Choi, Stephen Bloom, Han Wei, Yan Xing, Dan Gebow, Heidi Gransar, Hyuk-Jae Chang, Jonathon Leipsic, James K Min
OBJECTIVE: Motion artifact can reduce the diagnostic accuracy of coronary CT angiography (CCTA) for coronary artery disease (CAD). The purpose of this study was to compare the diagnostic performance of an algorithm dedicated to correcting coronary motion artifact with the performance of standard reconstruction methods in a prospective international multicenter study. SUBJECTS AND METHODS: Patients referred for clinically indicated invasive coronary angiography (ICA) for suspected CAD prospectively underwent an investigational CCTA examination free from heart rate-lowering medications before they underwent ICA...
June 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667261/apple-s-rnase-interacts-with-an-actin-binding-protein-mdmvg-to-reduce-pollen-tube-growth-by-inhibiting-its-actin-severing-activity-at-the-early-stage-of-self-pollination-induction
#15
Qing Yang, Dong Meng, Zhaoyu Gu, Wei Li, Qiuju Chen, Yang Li, Hui Yuan, Jie Yu, Chunsheng Liu, Tianzhong Li
In S-RNase-mediated self-incompatibility, S-RNase secreted from the style destroys the actin cytoskeleton of the self-pollen tubes, eventually halting their growth, but the mechanism of this process remains unclear. In vitro biochemical assays revealed that S-RNase does not bind or sever filamentous actin (F-actin). In apple (Malus domestica), we identified an actin-binding protein containing myosin, villin and GRAM (MdMVG), that physically interacts with S-RNase and directly binds and severs F-actin. Immunofluorescence assays and total internal reflection fluorescence microscopy indicated that S-RNase inhibits the F-actin-severing activity of MdMVG in vitro...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29666926/segmental-reversal-of-distal-small-intestine-in-short-bowel-syndrome-a-study-on-the-influence-on-postoperative-weight-and-intestinal-topography-in-piglets
#16
Pernille Kock Grave, Sabrina Valentin Thomsen, Pia Susanne Clark, Gunvor Iben Madsen, Niels Qvist, Mark Bremholm Ellebæk
PURPOSE: The objective of the present study was to investigate the effect of segmental reversal of the distal 20 cm of the small intestine in piglets with induced SBS compared to controls with SBS alone. Primary endpoint was postoperative weight change over a period of 1 month. Secondary endpoints were the influence on cell proliferation and mucosal architecture shown by histological analysis. METHODS: Sixteen piglets underwent a 60% resection of the distal small intestine and were randomized into two groups...
June 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29560090/mutation-of-tgf%C3%AE-rii-eliminates-nsaid-cancer-chemoprevention
#17
Juana Martín-López, Pierluigi Gasparini, Kevin Coombes, Carlo M Croce, Gregory P Boivin, Richard Fishel
Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit anti-neoplastic (chemoprevention) activity for sporadic cancers and the hereditary cancer predisposition Lynch syndrome (LS/HNPCC). However, the mechanism of NSAID tumor suppression has remained enigmatic. Defects in the core mismatch repair (MMR) genes MSH2 and MLH1 are the principal drivers of LS/HNPCC. Previous work has demonstrated that the villin - Cre+/- Msh2flox/flox (VpC-Msh2) mouse is a reliable model for LS/HNPCC intestinal tumorigenesis, which is significantly suppressed by treatment with the NSAID aspirin (ASA) similar to human chemoprevention...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29545477/therapeutic-effect-of-quinacrine-an-antiprotozoan-drug-by-selective-suppression-of-p-chk1-2-in-p53-negative-malignant-cancers
#18
Soyoung Park, Ah-Young Oh, Jung-Hyun Cho, Min-Ho Yoon, Tae-Gyun Woo, So-Mi Kang, Ho-Young Lee, Youn-Jin Jung, Bum-Joon Park
Quinacrine (QNC), antiprotozoan drug commonly used against Malaria and Giardiasis , has been recently tried for rheumatics and prion diseases via drug repositioning. In addition, several reports suggest antitumor effects of QNC through suppression of NF-κB and activation of p53. This study demonstrates the anticancer effect of QNC via a novel pathway through the elimination of checkpoint kinase 1/2 (Chk1/2) under p53-inactivated conditions. Inhibition of p53 by PFT-α or siRNA promotes QNC-induced apoptosis in normal fibroblast and p53-intact cancer cells...
March 15, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29534357/-value-of-immunocytochemistry-in-differential-diagnosis-of-gastric-adenocarcinoma-reactive-mesothelial-cells-and-malignant-epithelial-mesothelioma-in-metastatic-effusion-fluid
#19
M Lyu, N Cha, Y F Zou, J H Leng, L Xu, Y Sun, Y Y Hao
Objective: To investigate the diagnostic value of some antibodies in peritoneal fluid of patients with gastric cancer and malignant epithelioid mesothelioma in serous effusion. Methods: One hundred and eighty-two cases of serous effusion were collected at Jilin Cancer Hospital, from July 2012 to July 2016. The expression of GLUT1, CDX2, Villin, calretinin and WT1 was evaluated using SP immunocytochemical technique in peritoneal fluid samples collected from 98 patients with gastric cancer and 74 patients with reactive mesothelial cells...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29521447/influence-of-symptom-typicality-for-predicting-mace-in-patients-without-obstructive-coronary-artery-disease-from-the-confirm-registry-coronary-computed-tomography-angiography-evaluation-for-clinical-outcomes-an-international-multicenter-registry
#20
Ji Hyun Lee, Donghee Han, Bríain Ó Hartaigh, Heidi Gransar, Yao Lu, Asim Rizvi, Mahn Won Park, Hadi Mirhedayati Roudsari, Wijnand J Stuijfzand, Daniel S Berman, Tracy Q Callister, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Mouaz H Al-Mallah, Matthew J Budoff, Philipp A Kaufmann, Gilbert Raff, Kavitha Chinnaiyan, Filippo Cademartiri, Erica Maffei, Todd C Villines, Yong-Jin Kim, Jonathon Leipsic, Gudrun Feuchtner, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Stephan Achenbach, Leslee J Shaw, Hyuk-Jae Chang, Jeroen Bax, Benjamin Chow, Ricardo C Cury, Millie Gomez, Erica C Jones, Fay Y Lin, James K Min, Jessica M Peña
Our objective was to assess the prognostic value of symptom typicality in patients without obstructive coronary artery disease (CAD), determined by coronary computed tomographic angiography (CCTA). We identified 4215 patients without prior history of CAD and without obstructive CAD (<50% CCTA stenosis). CAD severity was categorized as nonobstructive (1%-49%) and none (0%). Based upon the Diamond-Forrester criteria for angina pectoris, symptom typicality was classified as asymptomatic, nonanginal, atypical, and typical...
March 9, 2018: Clinical Cardiology
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