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https://www.readbyqxmd.com/read/28170260/efficient-conformational-search-based-on-structural-dissimilarity-sampling-applications-for-reproducing-structural-transitions-of-proteins
#1
Ryuhei Harada, Yasuteru Shigeta
Structural Dissimilarity Sampling (SDS) is proposed as an efficient conformational search method to promote structural transitions essential for the biological functions of proteins. In SDS, initial structures are selected based on structural dissimilarity, and conformational resampling is repeated. Conformational resampling is performed as follows: (I) arrangement of initial structures for a diverse distribution at the edge of a conformational subspace, and (II) promotion of the structural transitions with multiple short-time molecular dynamics (MD) simulations restarting from the diversely distributed initial structures...
February 7, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28139876/mild-binding-of-protein-to-c2-n-monolayer-reveals-its-suitable-biocompatibility
#2
Baoyu Li, Weifeng Li, Jose Manuel Perez-Aguilar, Ruhong Zhou
The development of biocompatible nanomaterials for smart drug delivery and bioimaging has attracted great interest in recent years in biomedical fields. Here, the interaction between the recently reported nitrogenated graphene (C2 N) and a prototypical protein (villin headpiece HP35) utilizing atomistic molecular dynamics simulations is studied. The simulations reveal that HP35 can form a stable binding with the C2 N monolayer. Although the C2 N-HP35 attractive interactions are constantly preserved, the binding strength between C2 N and the protein is mild and does not cause significant distortion in the protein's structural integrity...
January 31, 2017: Small
https://www.readbyqxmd.com/read/28124181/drosophila-dunc-115-mediates-axon-projection-through-actin-binding
#3
Christopher Roblodowski, Qi He
A central step in organizing the central nervous system development is the growth cone of an axon navigating through guidance cues to reach its specific target. While a great deal of this process has been understood especially in identifying the extracellular guidance cues and their membrane receptors, much less is known about how guidance signals are further relayed to the actin filaments that are central to the mobility of the growth cone. The previous results from our laboratory have shown that Drosophila gene dunc-115 regulates axon projection in the eye and the central nervous system...
March 2017: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/28095874/clinicopathological-study-of-9-cases-of-prostate-cancer-involving-the-rectal-wall
#4
Tao Tang, Zhengduo Yang, Dan Zhang, Jie Qu, Guang Liu, Shiwu Zhang
BACKGROUND: Prostate cancer involving the rectal wall is rare and may lead to diagnostic pitfalls. CASE PRESENTATION: Out of 9504 patients with rectal tumors between January 2003 and January 2015, 9 patients (elderly with a mean age of 74 years) with prostate cancer involving the rectal wall were clinically misdiagnosed with rectal cancer. The lesions were located in the rectum, and included 3 circumferential rectal masses, 1 ulceration lesion, 1 crater-like mass, and 4 protruding lesions...
January 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28017553/coronary-computed-tomographic-angiography-the-evidence-dominates
#5
EDITORIAL
Leslee J Shaw, Todd Villines, Ron Blankstein, Suhny Abbara, Guy Weigold, Ahmad Slim, Jonathon Leipsic
No abstract text is available yet for this article.
January 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27999620/effects-of-escherichia-coli-nissle-1917-and-ciprofloxacin-on-small-intestinal-epithelial-cell-mrna-expression-in-the-neonatal-piglet-model-of-human-rotavirus-infection
#6
Francine C Paim, Stephanie N Langel, David D Fischer, Sukumar Kandasamy, Lulu Shao, Moyasar A Alhamo, Huang-Chi Huang, Anand Kumar, Gireesh Rajashekara, Linda J Saif, Anastasia N Vlasova
We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We analyzed mRNA levels of IEC genes for enteroendocrine cells [chromogranin A (CgA)], goblet cells [mucin 2 (MUC2)], transient amplifying progenitor cell [proliferating cell nuclear antigen (PCNA)], intestinal epithelial stem cell (SOX9) and enterocytes (villin)...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27993385/association-of-tobacco-use-and-cessation-with-coronary-atherosclerosis
#7
Michael K Cheezum, Alexander Kim, Marcio S Bittencourt, David Kassop, Alexander Nissen, Dustin M Thomas, Binh Nguyen, Robert J Glynn, Nishant R Shah, Todd C Villines
BACKGROUND AND AIMS: The impact of tobacco use and cessation on atherogenesis remains unclear. We aimed to study the association of tobacco use and prior cessation with the presence, extent and severity of atherosclerosis on coronary computed tomographic angiography (CTA). METHODS: We examined 1798 consecutive symptomatic patients without known coronary artery disease (CAD) referred for CTA, stratified by smoking status (never, current [within 30 days], or former [>30 days before CTA])...
November 16, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27935584/ketogenesis-contributes-to-intestinal-cell-differentiation
#8
Qingding Wang, Yuning Zhou, Piotr Rychahou, Teresa W-M Fan, Andrew N Lane, Heidi L Weiss, B Mark Evers
The intestinal epithelium undergoes a continual process of proliferation, differentiation and apoptosis. Previously, we have shown that the PI3K/Akt/mTOR pathway has a critical role in intestinal homeostasis. However, the downstream targets mediating the effects of mTOR in intestinal cells are not known. Here, we show that the ketone body β-hydroxybutyrate (βHB), an endogenous inhibitor of histone deacetylases (HDACs) induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21(Waf1))...
December 9, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27906736/an-exploratory-descriptive-study-of-registered-nurse-innovation-implications-for-levels-of-adoption
#9
Debra Polster, Dana Villines
PURPOSE: The aims of this study were to describe registered nurses' levels of personal innovativeness and registered nurses' perceived organizational innovativeness and determine the relationship between these 2 variables. BACKGROUND: There is limited research to describe the levels of innovation of nurses within a hospital. The levels of innovation can determine the likelihood of adoption of evidence-based practices at the bedside. As change agents, clinical nurse specialists can determine successful implementation strategies tailored to nurse levels of innovation...
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27893642/comparison-of-nonoperative-and-surgical-management-of-renal-trauma-can-we-predict-when-nonoperative-management-fails
#10
Marc A Bjurlin, Richard Jacob Fantus, Richard Joseph Fantus, Dana Villines
BACKGROUND: Limited data exist on risk factors for the failure of nonoperative management of renal trauma. Our study objective was to determine the incidence, salvage procedure, and risk factors for failure of nonoperative management of renal trauma. METHODS: The National Trauma Data Bank research data sets for admission years 2010-2014 were queried for renal injury by Abbreviated Injury Score code. Patients were stratified by interventional therapy (renal procedure code <24 hours from admission) and nonoperative management (no surgical renal procedure <24 hours)...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27876863/intestinal-tuft-cells-regulate-the-atm-mediated-dna-damage-response-via-dclk1-dependent-mechanism-for-crypt-restitution-following-radiation-injury
#11
Parthasarathy Chandrakesan, Randal May, Nathaniel Weygant, Dongfeng Qu, William L Berry, Sripathi M Sureban, Naushad Ali, Chinthalapally Rao, Mark Huycke, Michael S Bronze, Courtney W Houchen
Crypt epithelial survival and regeneration after injury require highly coordinated complex interplay between resident stem cells and diverse cell types. The function of Dclk1 expressing tuft cells regulating intestinal epithelial DNA damage response for cell survival/self-renewal after radiation-induced injury is unclear. Intestinal epithelial cells (IECs) were isolated and purified and utilized for experimental analysis. We found that small intestinal crypts of Villin(Cre);Dclk1(f/f) mice were hypoplastic and more apoptotic 24 h post-total body irradiation, a time when stem cell survival is p53-independent...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876580/management-of-dry-mouth-assessment-of-oral-symptoms-after-use-of-a-polysaccharide-based-oral-rinse
#12
Joel B Epstein, Dana C Villines, Mabi Singh, Athena Papas
OBJECTIVE: Salivary dysfunction is associated with a range of oral/dental issues, and management of oral symptoms may improve oral function and overall quality of life. The purpose of this pilot study was to evaluate oral symptoms and function in a xerostomic population after use of a proprietary topical for dry mouth, Moisyn (Synedgen Inc., Claremont, CA), which is a polysaccharide-based product. STUDY DESIGN: A pre- and post-test survey was completed by 57 patients with xerostomia...
January 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27875772/hnf4%C3%AE-is-a-key-gene-that-can-generate-columnar-metaplasia-in-oesophageal-epithelium
#13
Benjamin J Colleypriest, Zoë D Burke, Leonard P Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M Quinlan, Stephen G Ward, J Mark Farrant, Jonathan M W Slack, David Tosh
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms responsible for the change in cellular phenotype are poorly understood. We therefore explored the role of two transcription factors, Cdx2 and HNF4α in the conversion using primary organ cultures. Biopsy samples from cases of human Barrett's metaplasia were analysed for the presence of CDX2 and HNF4α...
January 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27856416/regulation-and-function-of-bone-morphogenetic-protein-signaling-in-colonic-injury-and-inflammation
#14
Tuo Ji, Hidehiko Takabayashi, Maria Mao, Xu Han, Xiang Xue, Jennifer C Brazil, Kathryn A Eaton, Yatrik M Shah, Andrea Todisco
: The bone morphogenetic proteins (BMPs) regulate gastrointestinal homeostasis. We investigated the expression of BMP-4 and the localization and function of BMP signaling during colonic injury and inflammation. Mice expressing the β-galactosidase (β-gal) gene under the control of a BMP-responsive element (BRE), BMP-4-β-gal/ mice, and animals generated by crossing villin-Cre mice to mice with floxed alleles of BMP receptor 1A (villin-Cre;Bmpr1a(flox/flox)) were treated with dextran sodium sulfate (DSS) to induce colonic injury and inflammation...
January 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27810052/serving-to-heal-and-honored-to-serve-an-insight-into-military-cardiovascular-fellowship
#15
EDITORIAL
Emilio Fentanes, Dylan Wessman, Todd C Villines, Kevin E Steel
No abstract text is available yet for this article.
November 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27780758/scct-guidelines-for-the-performance-and-acquisition-of-coronary-computed-tomographic-angiography-a-report-of-the-society-of-cardiovascular-computed-tomography-guidelines-committee-endorsed-by-the-north-american-society-for-cardiovascular-imaging-nasci
#16
Suhny Abbara, Philipp Blanke, Christopher D Maroules, Michael Cheezum, Andrew D Choi, B Kelly Han, Mohamed Marwan, Chris Naoum, Bjarne L Norgaard, Ronen Rubinshtein, Paul Schoenhagen, Todd Villines, Jonathon Leipsic
In response to recent technological advancements in acquisition techniques as well as a growing body of evidence regarding the optimal performance of coronary computed tomography angiography (coronary CTA), the Society of Cardiovascular Computed Tomography Guidelines Committee has produced this update to its previously established 2009 "Guidelines for the Performance of Coronary CTA" (1). The purpose of this document is to provide standards meant to ensure reliable practice methods and quality outcomes based on the best available data in order to improve the diagnostic care of patients...
November 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27769115/molecular-mechanism-behind-the-fast-folding-unfolding-transitions-of-villin-headpiece-subdomain-hierarchy-and-heterogeneity
#17
Toshifumi Mori, Shinji Saito
Proteins involve motions over a wide range of spatial and temporal scales. While the large conformational changes, such as folding and functioning, are slow and appear to occur in a highly cooperative manner, how the hierarchical dynamics over different time scales play a role during these slow transitions has been of great interest over the decades. Here we study the folding mechanism of the villin headpiece subdomain (HP35) to understand the molecular mechanism behind this prototypical fast-folding protein...
November 17, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27765954/both-the-anti-and-pro-apoptotic-functions-of-villin-regulate-cell-turnover-and-intestinal-homeostasis
#18
Yaohong Wang, Sudeep P George, Swati Roy, Eric Pham, Amin Esmaeilniakooshkghazi, Seema Khurana
In the small intestine, epithelial cells are derived from stem cells in the crypts, migrate up the villus as they differentiate and are ultimately shed from the villus tips. This process of proliferation and shedding is tightly regulated to maintain the intestinal architecture and tissue homeostasis. Apoptosis regulates both the number of stem cells in the crypts as well as the sloughing of cells from the villus tips. Previously, we have shown that villin, an epithelial cell-specific actin-binding protein functions as an anti-apoptotic protein in the gastrointestinal epithelium...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754204/apsh-yi-03-essential-role-of-intestinal-epithelial-mineralocorticoid-receptor-in-the-regulation-of-sodium-absorption-and-blood-pressure
#19
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
OBJECTIVE: Recent studies have unveiled cardiovascular pathological roles of mineralocorticoid receptor (MR) in many types of cells. Although we have confirmed high expression of MR in intestinal epithelial cells (IEC), that role in progression of cardiovascular diseases is yet to be elucidated. As intestine is the first gate sensing sodium intake, MR of this organ is expected to have essential roles in blood pressure (BP) regulation. This study investigated the role of MR in IEC by using IEC-specific MR knockout mice (IEC-MR KO)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744434/comparative-proteomics-analysis-of-mouse-habu-nephritis-models-with-and-without-unilateral-nephrectomy
#20
COMPARATIVE STUDY
Lei Chen, Yang Lu, Jun Wen, Xu Wang, Lingling Wu, Di Wu, Xuefeng Sun, Bo Fu, Zhong Yin, Hongli Jiang, Xiangmei Chen
BACKGROUND/AIMS: Individuals possessing a single kidney are at greater risk of renal injury upon exposure to harmful stimuli. This study aimed to explore the pathogenesis of renal injury in glomerulonephritis with versus without unilateral nephrectomy (UNX). METHODS: Histological analysis and label-free quantitative proteomics were performed on two models-the Habu snake venom-induced glomerulonephritis model with versus without UNX (HabuU and Habu models, respectively)...
2016: Cellular Physiology and Biochemistry
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