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https://www.readbyqxmd.com/read/29560090/mutation-of-tgf%C3%AE-rii-eliminates-nsaid-cancer-chemoprevention
#1
Juana Martín-López, Pierluigi Gasparini, Kevin Coombes, Carlo M Croce, Gregory P Boivin, Richard Fishel
Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit anti-neoplastic (chemoprevention) activity for sporadic cancers and the hereditary cancer predisposition Lynch syndrome (LS/HNPCC). However, the mechanism of NSAID tumor suppression has remained enigmatic. Defects in the core mismatch repair (MMR) genes MSH2 and MLH1 are the principal drivers of LS/HNPCC. Previous work has demonstrated that the villin - Cre+/- Msh2flox/flox (VpC-Msh2) mouse is a reliable model for LS/HNPCC intestinal tumorigenesis, which is significantly suppressed by treatment with the NSAID aspirin (ASA) similar to human chemoprevention...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29545477/therapeutic-effect-of-quinacrine-an-anti-protozoan-drug-by-selective-suppression-of-p-chk1-2-in-p53-negative-malignant-cancers
#2
Soyoung Park, Ah-Young Oh, Jung-Hyun Cho, Min-Ho Yoon, Tae-Guen Woo, Somi Kang, Ho-Young Lee, Yunjin Jung, Bum-Joon Park
Quinacrine (QNC), anti-protozoan drug commonly used against Malaria and Giardiasis, has been recently tried for rheumatics and prion diseases via drug repositioning. In addition, several reports suggest anti-tumor effects of QNC through suppression of NF-κB and activation of p53. This study, demonstrates the anti-cancer effect of QNC via a novel pathway through the elimination of check point kinase 1/2 (Chk1/2) under p53 inactivated conditions. Inhibition of p53, by PFT-α or siRNA, promotes QNC-induced apoptosis in normal fibroblast and p53-intact cancer cells...
March 15, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29534357/-value-of-immunocytochemistry-in-differential-diagnosis-of-gastric-adenocarcinoma-reactive-mesothelial-cells-and-malignant-epithelial-mesothelioma-in-metastatic-effusion-fluid
#3
M Lyu, N Cha, Y F Zou, J H Leng, L Xu, Y Sun, Y Y Hao
Objective: To investigate the diagnostic value of some antibodies in peritoneal fluid of patients with gastric cancer and malignant epithelioid mesothelioma in serous effusion. Methods: One hundred and eighty-two cases of serous effusion were collected at Jilin Cancer Hospital, from July 2012 to July 2016. The expression of GLUT1, CDX2, Villin, calretinin and WT1 was evaluated using SP immunocytochemical technique in peritoneal fluid samples collected from 98 patients with gastric cancer and 74 patients with reactive mesothelial cells...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29521447/influence-of-symptom-typicality-for-predicting-mace-in-patients-without-obstructive-coronary-artery-disease-from-the-confirm-registry-coronary-computed-tomography-angiography-evaluation-for-clinical-outcomes-an-international-multicenter-registry
#4
Ji Hyun Lee, Donghee Han, Bríain Ó Hartaigh, Heidi Gransar, Yao Lu, Asim Rizvi, Mahn Won Park, Hadi Mirhedayati Roudsari, Wijnand J Stuijfzand, Daniel S Berman, Tracy Q Callister, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Mouaz H Al-Mallah, Matthew J Budoff, Philipp A Kaufmann, Gilbert Raff, Kavitha Chinnaiyan, Filippo Cademartiri, Erica Maffei, Todd C Villines, Yong-Jin Kim, Jonathon Leipsic, Gudrun Feuchtner, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Stephan Achenbach, Leslee J Shaw, Hyuk-Jae Chang, Jeroen Bax, Benjamin Chow, Ricardo C Cury, Millie Gomez, Erica C Jones, Fay Y Lin, James K Min, Jessica M Peña
OBJECTIVE: To assess the prognostic value of symptom typicality in patients without obstructive coronary artery disease (CAD), determined by coronary computed tomographic angiography (CCTA). METHODS: 4,215 patients without prior history of CAD and without obstructive CAD (<50% CCTA stenosis) were identified. CAD severity was categorized as non-obstructive (1%-49%) and none (0%). Based upon the Diamond-Forrester criteria for angina pectoris, symptom typicality was classified as: asymptomatic, non-anginal, atypical, and typical...
March 9, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29512170/importance-of-baseline-heart-rate-as-a-predictor-of-cardiac-functional-recovery-in-newly-diagnosed-heart-failure-with-reduced-ejection-fraction
#5
Ali Valika, Kim Paprockas, Dana Villines, Maria Rosa Costanzo
BACKGROUND: Left ventricular ejection fraction (LVEF) has shown to predict outcomes in patients with heart failure (HF). Left ventricular recovery (LVR) has shown to improve prognosis. HYPOTHESIS: Guideline directed medical therapy (GDMT) will predict LVR in patients with HF and reduced EF. METHODS: 244 patients with newly diagnosed HF and a LVEF ≤ 35% were studied. LVR was defined as an increase in LVEF ≥ 40%. Patients who experienced LVR were compared to those who had persistent left ventricular dysfunction (LVD)...
March 7, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29490628/variance-component-analysis-to-assess-protein-quantification-in-biomarker-validation-application-to-selected-reaction-monitoring-mass-spectrometry
#6
Amna Klich, Catherine Mercier, Laurent Gerfault, Pierre Grangeat, Corinne Beaulieu, Elodie Degout-Charmette, Tanguy Fortin, Pierre Mahé, Jean-François Giovannelli, Jean-Philippe Charrier, Audrey Giremus, Delphine Maucort-Boulch, Pascal Roy
BACKGROUND: In the field of biomarker validation with mass spectrometry, controlling the technical variability is a critical issue. In selected reaction monitoring (SRM) measurements, this issue provides the opportunity of using variance component analysis to distinguish various sources of variability. However, in case of unbalanced data (unequal number of observations in all factor combinations), the classical methods cannot correctly estimate the various sources of variability, particularly in presence of interaction...
March 1, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29489510/clinicopathologic-significance-of-intestinal-type-molecules-expression-and-different-egfr-gene-status-in-pulmonary-adenocarcinoma
#7
Chang Feng, Man Feng, Yujun Gao, Xiaogang Zhao, Chuanliang Peng, Xiangshan Yang, Jing Zhang
Variant pulmonary adenocarcinoma with intestinal-type molecules shares similar molecular expression with colorectal carcinoma. However, expression of such molecules and their association with survival time with clinicopathologic parameters, such as epidermal growth factor receptor (EGFR) gene status in other types of pulmonary adenocarcinoma, has been rarely demonstrated. Sixty patients with resected pulmonary adenocarcinoma were divided into the enteric differentiation group (I group, n=30) and the usual group (U group, n=30)...
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29488037/severe-intestinal-inflammation-in-the-small-intestine-of-mice-induced-by-controllable-deletion-of-claudin-7
#8
Wen-Jing Li, Chang Xu, Kun Wang, Teng-Yan Li, Xiao-Nan Wang, Hui Yang, Tiaosi Xing, Wen-Xia Li, Yan-Hua Chen, Hong Gao, Lei Ding
BACKGROUND: As a potential tumor suppressor gene, Claudin-7 (Cldn7), which is a component of tight junctions, may play an important role in colorectal cancer occurrence and development. AIMS: To generate a knockout mouse model of inducible conditional Cldn7 in the intestine and analyze the phenotype of the mice after induction with tamoxifen. METHODS: We constructed Cldn7-flox transgenic mice and crossed them with Villin-CreERT2 mice. The Cldn7 inducible conditional knockout mice appeared normal and were well developed at birth...
February 27, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29475623/scct-president-s-page-exceeding-expectations-and-delivering-excellence-from-london-to-dallas-in-2018
#9
EDITORIAL
Todd C Villines
No abstract text is available yet for this article.
February 14, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29471325/dual-stain-with-satb2-and-ck20-villin-is-useful-to-distinguish-colorectal-carcinomas-from-other-tumors
#10
Zaibo Li, Jonathan B Rock, Rachel Roth, Amy Lehman, William L Marsh, Adrian Suarez, Wendy L Frankel
Objectives: Small sample size limits the number of immunostains that may be attempted in colorectal carcinoma (CRC) biopsy specimens. We investigated the utility of dual stain with special AT-rich sequence binding protein 2 (SATB2) or caudal-type homeobox 2 (CDX2) and cytokeratin 20 (CK20) or villin in identifying CRC. Methods: Tissue microarrays with 222 CRCs and 375 other carcinomas were built. Dual stain was performed pairing nuclear stains CDX2 or SATB2 with CK20 or villin...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29455300/patterns-of-oral-and-dental-care-education-and-utilization-in-head-and-neck-cancer-patients
#11
Joel B Epstein, Derek K Smith, Dana Villines, Ira Parker, Jeff Hameroff, Brian R Hill, Barbara A Murphy
PURPOSE: The purpose of this study was to examine patterns of oral health care among patients undergoing oral cancer therapy in order to better understand how oral care is being utilized, what types of providers are being utilized at various stages of cancer therapy, and assessing patients' satisfaction with the care they received at these stages. METHODS: An online survey was conducted via the Oral Cancer Foundation's support group message board. Participants were asked about their oral care immediately prior to cancer therapy, during cancer therapy, and post cancer therapy...
February 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29444403/plant-villin-headpiece-domain-demonstrates-a-novel-surface-charge-pattern-and-high-affinity-for-f-actin
#12
Heather L Miears, David R Gruber, Nicholas M Horvath, John M Antos, Jeff Young, Johann P Sigurjonsson, Maya L Klem, Erin A Rosenkranz, Mark Okon, Christopher James McKnight, Liliya Vugmeyster, Serge L Smirnov
Plants utilize multiple isoforms of villin, an F-actin regulating protein with an N-terminal gelsolin-like core and a distinct C-terminal headpiece domain. Unlike their vertebrate homologs, plant villins have a much longer linker polypeptide connecting the core and headpiece. Moreover, the linker-headpiece connection region in plant villins lack sequence homology to the vertebrate villin sequences. It is unknown to what extent the plant villin headpiece structure and function resemble those of the well-studied vertebrate counterparts...
February 14, 2018: Biochemistry
https://www.readbyqxmd.com/read/29415989/sphingolipid-de-novo-biosynthesis-is-essential-for-intestine-cell-survival-and-barrier-function
#13
Zhiqiang Li, Inamul Kabir, Gladys Tietelman, Chongmin Huan, Jianglin Fan, Tilla Worgall, Xian-Cheng Jiang
Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis. SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 deficiency in early life impairs the development of adherens junctions. Here, we investigated the role of Sptlc2 deficiency in intestine. We treated Sptlc2-Flox/villin-Cre-ERT2 mice with tamoxifen (days 1, 2, and 3) to ablate Sptlc2 specifically in the intestine. At day 6 after tamoxifen treatment, Sptlc2-deficient mice had significantly decreased body weight with concurrent diarrhea and rectal bleeding...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29401328/implications-of-new-cholesterol-treatment-guidelines-on-statin-utilization-intensity-and-costs-in-active-duty-service-members
#14
Michael S Cahill, Rebecca M Seifried, Julia H Cheringal, Nicholas R Fiacco, Patrick S Moon, Michael K Cheezum, Todd C Villines
Background: The recommendations in the 2013 American College of Cardiology/American Heart Association (ACC/AHA) blood cholesterol guidelines expanded the indications and level of intensity of statin therapy for the primary prevention of cardiovascular disease. We assessed the treatment and cost implications of theseguidelines within a cohort of active duty service members. Methods: Using the military electronic medical record system, the Armed Forces Health Longitudinal Technology Application, we randomly selected 1,000 active duty persons aged 40 yr or older and reviewed their lipid profiles and medical records to identify risk factors for atherosclerotic cardiovascular disease...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29396193/prone-patient-positioning-to-exclude-left-atrial-appendage-thrombus-using-cardiac-ct
#15
Hampton A Crimm, Justin R Taylor, Brian T Fogarty, Todd C Villines
No abstract text is available yet for this article.
January 27, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29394067/integrating-multiple-accelerated-molecular-dynamics-to-improve-accuracy-of-free-energy-calculation
#16
Xiangda Peng, Yuebin Zhang, Yan Li, Qinglong Liu, Huiying Chu, Dinglin Zhang, Guohui Li
Accelerated Molecular Dynamics (aMD) is a promising enhanced sampling method to explore the conformational space of biomolecules. However, the large statistical noise in reweighting limits its accuracy to recover the original free energy profile. In this work, we propose an Integrated accelerated Molecule Dynamics (IaMD) method by integrating a series of aMD sub-terms with different acceleration parameters to improve the sampling efficiency and maintain the reweighting accuracy simultaneously. We use Alanine Dipeptide and three fast-folded proteins (Chignolin, Trp-cage, and Villin Headpiece) as the test objects to compare our IaMD method with aMD systematically...
February 2, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29375717/diagnosis-clinicopathological-characteristics-and-prognosis-of-pulmonary-mucinous-adenocarcinoma
#17
Fei Sun, Pengcheng Wang, Yiming Zheng, Weiguang Jia, Fuxing Liu, Wei Xiao, Jingjing Bao, Song Wang, Kaijin Lu
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of the tumours expressed CK7 and 5 cases exhibited co-expression with CK20...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29365193/prognostic-value-of-coronary-computed-tomographic-angiography-findings-in-asymptomatic-individuals-a-6-year-follow-up-from-the-prospective-multicentre-international-confirm-study
#18
Iksung Cho, Subhi J Al'Aref, Adam Berger, Bríain Ó Hartaigh, Heidi Gransar, Valentina Valenti, Fay Y Lin, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathon Leipsic, Leslee J Shaw, Philipp A Kaufmann, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Hyuk-Jae Chang, James K Min
Aim: The long-term prognostic benefit of coronary computed tomographic angiography (CCTA) findings of coronary artery disease (CAD) in asymptomatic populations is unknown. Methods and results: From the prospective multicentre international CONFIRM long-term study, we evaluated asymptomatic subjects without known CAD who underwent both coronary artery calcium scoring (CACS) and CCTA (n = 1226). Coronary computed tomographic angiography findings included the severity of coronary artery stenosis, plaque composition, and coronary segment location...
January 20, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29322087/the-endosomal-protein-endotubin-is-required-for-enterocyte-differentiation
#19
Christopher M Cox, Ruifeng Lu, Kaan Salcin, Jean M Wilson
Background & Aims: During late embryonic development and through weaning, enterocytes of the ileum are highly endocytic. Defects in endocytosis and trafficking are implicated in neonatal disease, however, the mechanisms regulating trafficking during the developmental period are incompletely understood. The apical endosomal protein endotubin (EDTB) is highly expressed in the late embryonic and neonatal ileum. In epithelial cells in vitro, EDTB regulates both trafficking of tight junction proteins and proliferation through modulation of YAP activity...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29306630/scct-president-s-page-scct-in-2018-new-year-resolutions
#20
EDITORIAL
Todd C Villines, Joanne Olson
No abstract text is available yet for this article.
January 2018: Journal of Cardiovascular Computed Tomography
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