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https://www.readbyqxmd.com/read/29455300/patterns-of-oral-and-dental-care-education-and-utilization-in-head-and-neck-cancer-patients
#1
Joel B Epstein, Derek K Smith, Dana Villines, Ira Parker, Jeff Hameroff, Brian R Hill, Barbara A Murphy
PURPOSE: The purpose of this study was to examine patterns of oral health care among patients undergoing oral cancer therapy in order to better understand how oral care is being utilized, what types of providers are being utilized at various stages of cancer therapy, and assessing patients' satisfaction with the care they received at these stages. METHODS: An online survey was conducted via the Oral Cancer Foundation's support group message board. Participants were asked about their oral care immediately prior to cancer therapy, during cancer therapy, and post cancer therapy...
February 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29444403/plant-villin-headpiece-domain-demonstrates-a-novel-surface-charge-pattern-and-high-affinity-for-f-actin
#2
Heather L Miears, David R Gruber, Nicholas M Horvath, John M Antos, Jeff Young, Johann P Sigurjonsson, Maya L Klem, Erin A Rosenkranz, Mark Okon, Christopher James McKnight, Liliya Vugmeyster, Serge L Smirnov
Plants utilize multiple isoforms of villin, an F-actin regulating protein with an N-terminal gelsolin-like core and a distinct C-terminal headpiece domain. Unlike their vertebrate homologs, plant villins have a much longer linker polypeptide connecting the core and headpiece. Moreover, the linker-headpiece connection region in plant villins lack sequence homology to the vertebrate villin sequences. It is unknown to what extent the plant villin headpiece structure and function resemble those of the well-studied vertebrate counterparts...
February 14, 2018: Biochemistry
https://www.readbyqxmd.com/read/29415989/sphingolipid-de-novo-biosynthesis-is-essential-for-intestine-cell-survival-and-barrier-function
#3
Zhiqiang Li, Inamul Kabir, Gladys Tietelman, Chongmin Huan, Jianglin Fan, Tilla Worgall, Xian-Cheng Jiang
Serine palmitoyltransferase (SPT) is the rate-limiting enzyme for sphingolipid biosynthesis. SPT has two major subunits, SPTLC1 and SPTLC2. We previously found that liver Sptlc2 deficiency in early life impairs the development of adherens junctions. Here, we investigated the role of Sptlc2 deficiency in intestine. We treated Sptlc2-Flox/villin-Cre-ERT2 mice with tamoxifen (days 1, 2, and 3) to ablate Sptlc2 specifically in the intestine. At day 6 after tamoxifen treatment, Sptlc2-deficient mice had significantly decreased body weight with concurrent diarrhea and rectal bleeding...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29401328/implications-of-new-cholesterol-treatment-guidelines-on-statin-utilization-intensity-and-costs-in-active-duty-service-members
#4
Michael S Cahill, Rebecca M Seifried, Julia H Cheringal, Nicholas R Fiacco, Patrick S Moon, Michael K Cheezum, Todd C Villines
Background: The recommendations in the 2013 American College of Cardiology/American Heart Association (ACC/AHA) blood cholesterol guidelines expanded the indications and level of intensity of statin therapy for the primary prevention of cardiovascular disease. We assessed the treatment and cost implications of theseguidelines within a cohort of active duty service members. Methods: Using the military electronic medical record system, the Armed Forces Health Longitudinal Technology Application, we randomly selected 1,000 active duty persons aged 40 yr or older and reviewed their lipid profiles and medical records to identify risk factors for atherosclerotic cardiovascular disease...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29396193/prone-patient-positioning-to-exclude-left-atrial-appendage-thrombus-using-cardiac-ct
#5
Hampton A Crimm, Justin R Taylor, Brian T Fogarty, Todd C Villines
No abstract text is available yet for this article.
January 27, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29394067/integrating-multiple-accelerated-molecular-dynamics-to-improve-accuracy-of-free-energy-calculation
#6
Xiangda Peng, Yuebin Zhang, Yan Li, Qinglong Liu, Huiying Chu, Dinglin Zhang, Guohui Li
Accelerated Molecular Dynamics (aMD) is a promising enhanced sampling method to explore the conformational space of biomolecules. However, the large statistical noise in reweighting limits its accuracy to recover the original free energy profile. In this work, we propose an Integrated accelerated Molecule Dynamics (IaMD) method by integrating a series of aMD sub-terms with different acceleration parameters to improve the sampling efficiency and maintain the reweighting accuracy simultaneously. We use Alanine Dipeptide and three fast-folded proteins (Chignolin, Trp-cage, and Villin Headpiece) as the test objects to compare our IaMD method with aMD systematically...
February 2, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29375717/diagnosis-clinicopathological-characteristics-and-prognosis-of-pulmonary-mucinous-adenocarcinoma
#7
Fei Sun, Pengcheng Wang, Yiming Zheng, Weiguang Jia, Fuxing Liu, Wei Xiao, Jingjing Bao, Song Wang, Kaijin Lu
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of the tumours expressed CK7 and 5 cases exhibited co-expression with CK20...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29365193/prognostic-value-of-coronary-computed-tomographic-angiography-findings-in-asymptomatic-individuals-a-6-year-follow-up-from-the-prospective-multicentre-international-confirm-study
#8
Iksung Cho, Subhi J Al'Aref, Adam Berger, Bríain Ó Hartaigh, Heidi Gransar, Valentina Valenti, Fay Y Lin, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathon Leipsic, Leslee J Shaw, Philipp A Kaufmann, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Hyuk-Jae Chang, James K Min
Aim: The long-term prognostic benefit of coronary computed tomographic angiography (CCTA) findings of coronary artery disease (CAD) in asymptomatic populations is unknown. Methods and results: From the prospective multicentre international CONFIRM long-term study, we evaluated asymptomatic subjects without known CAD who underwent both coronary artery calcium scoring (CACS) and CCTA (n = 1226). Coronary computed tomographic angiography findings included the severity of coronary artery stenosis, plaque composition, and coronary segment location...
January 20, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29322087/the-endosomal-protein-endotubin-is-required-for-enterocyte%C3%A2-differentiation
#9
Christopher M Cox, Ruifeng Lu, Kaan Salcin, Jean M Wilson
Background & Aims: During late embryonic development and through weaning, enterocytes of the ileum are highly endocytic. Defects in endocytosis and trafficking are implicated in neonatal disease, however, the mechanisms regulating trafficking during the developmental period are incompletely understood. The apical endosomal protein endotubin (EDTB) is highly expressed in the late embryonic and neonatal ileum. In epithelial cells in vitro, EDTB regulates both trafficking of tight junction proteins and proliferation through modulation of YAP activity...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29306630/scct-president-s-page-scct-in-2018-new-year-resolutions
#10
EDITORIAL
Todd C Villines, Joanne Olson
No abstract text is available yet for this article.
December 13, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29303613/cellular-differentiation-of-non-transformed-intestinal-epithelial-cells-is-regulated-by-lactobacillus-rhamnosus-and-l-casei-strains
#11
J Kolinska, M Zakostelecka, Z Zemanova, V Lisa, J Golias, H Kozakova, B Dvorak
The aim of this study was to characterize an in vitro modulating effect of three commensal Lactobacillus strains on cellular differentiation of non-transformed crypt-like rat small intestinal cell line IEC-18. IEC-18 was grown on extracellular matrix (ECM), with or without presence of Lactobacillus strains. Gene expression of IEC-18 bacterial detection system - such as Toll-like receptors TLR-2, TLR-4, signal adapter MyD88, cytoplasmic NOD2 receptor, inflammatory cytokines IL-18, IL-1beta, chemokine IL-8 and enzyme caspase-1 - was evaluated using real-time PCR...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29301713/the-coronary-artery-disease-reporting-and-data-system-cad-rads-prognostic-and-clinical-implications-associated-with-standardized-coronary-computed-tomography-angiography-reporting
#12
Joe X Xie, Ricardo C Cury, Jonathon Leipsic, Matthew T Crim, Daniel S Berman, Heidi Gransar, Matthew J Budoff, Stephan Achenbach, Bríain Ó Hartaigh, Tracy Q Callister, Hugo Marques, Ronen Rubinshtein, Mouaz H Al-Mallah, Daniele Andreini, Gianluca Pontone, Filippo Cademartiri, Erica Maffei, Kavitha Chinnaiyan, Gilbert Raff, Martin Hadamitzky, Joerg Hausleiter, Gudrun Feuchtner, Allison Dunning, Augustin DeLago, Yong-Jin Kim, Philipp A Kaufmann, Todd C Villines, Benjamin J W Chow, Niree Hindoyan, Millie Gomez, Fay Y Lin, Erica Jones, James K Min, Leslee J Shaw
OBJECTIVES: This study sought to assess clinical outcomes associated with the novel Coronary Artery Disease-Reporting and Data System (CAD-RADS) scores used to standardize coronary computed tomography angiography (CTA) reporting and their potential utility in guiding post-coronary CTA care. BACKGROUND: Clinical decision support is a major focus of health care policies aimed at improving guideline-directed care. Recently, CAD-RADS was developed to standardize coronary CTA reporting and includes clinical recommendations to facilitate patient management after coronary CTA...
January 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29289136/principal-component-analysis-on-a-torus-theory-and-application-to-protein-dynamics
#13
Florian Sittel, Thomas Filk, Gerhard Stock
A dimensionality reduction method for high-dimensional circular data is developed, which is based on a principal component analysis (PCA) of data points on a torus. Adopting a geometrical view of PCA, various distance measures on a torus are introduced and the associated problem of projecting data onto the principal subspaces is discussed. The main idea is that the (periodicity-induced) projection error can be minimized by transforming the data such that the maximal gap of the sampling is shifted to the periodic boundary...
December 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29274870/villin-1-and-gelsolin-regulate-changes-in-actin-dynamics-that-affect-cell-survival-signaling-pathways-and-intestinal-inflammation
#14
Swati Roy, Amin Esmaeilniakooshkghazi, Srinivas Patnaik, Yaohong Wang, Sudeep P George, Afzal Ahrorov, Jason K Hou, Allan J Herron, Hiromi Sesaki, Seema Khurana
BACKGROUND & AIMS: Cell stress signaling pathways result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), which affects regulation of protein translation. Translation reprogramming mitigates stress by activating pathways that result in autophagy and cell death, to eliminate damaged cells. Actin is modified during stress and EIF2A is dephosphorylated to restore homeostasis. It is not clear how actin affects EIF2A signaling. We studied the actin-binding proteins villin 1 (VIL1) and gelsolin (GSN) in intestinal epithelial cells (IECs) to determine whether they respond to cell stress response and affect signaling pathways...
December 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29228157/gut-epithelial-vitamin-d-receptor-regulates-microbiota-dependent-mucosal-inflammation-by-suppressing-intestinal-epithelial-cell-apoptosis
#15
Lei He, Tianjing Liu, Yongyan Shi, Feng Tian, Huiyuan Hu, Dilip K Deb, Yinyin Chen, Marc Bissonnette, Yan Chun Li
Recent studies show that colonic vitamin D receptor (VDR) signaling protects the mucosal epithelial barrier and suppresses colonic inflammation, but the underlying molecular mechanism remains to be fully understood. To investigate the implication of colonic VDR down-regulation seen in patients with inflammatory bowel disease, we assessed the effect of gut epithelial VDR deletion on colonic inflammatory responses in an experimental colitis model. In 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model, mice carrying VDR deletion in gut epithelial cells (VDRf/f;Villin-Cre or VDRΔIEC) or in colonic epithelial cells (VDRf/f;CDX2-Cre or VDRΔCEC) developed more severe clinical colitis than VDRf/f control mice, characterized by more robust TH1 and TH17 responses, with greater increases in mucosal IFN-γ+, IL-17+ and IFN-γ+IL-17+ T cells...
December 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/29216297/skn-1a-pou2f3-functions-as-a-master-regulator-to-generate-trpm5-expressing-chemosensory-cells-in-mice
#16
Junpei Yamashita, Makoto Ohmoto, Tatsuya Yamaguchi, Ichiro Matsumoto, Junji Hirota
Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami, and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the nasal respiratory epithelium, and tuft cells in the small intestine, that express taste-related genes function as chemosensory cells. Previous studies demonstrated that Skn-1a/Pou2f3, a POU homeodomain transcription factor is expressed in these Trpm5-expressing chemosensory cells, and is necessary for their generation. Trpm5-expressing cells have recently been found in trachea, auditory tube, urethra, thymus, pancreatic duct, stomach, and large intestine...
2017: PloS One
https://www.readbyqxmd.com/read/29212456/helicobacter-induced-gastric-inflammation-alters-the-properties-of-gastric-tissue-stem-progenitor-cells
#17
Wataru Shibata, Soichiro Sue, Sachiko Tsumura, Yasuaki Ishii, Takeshi Sato, Eri Kameta, Makoto Sugimori, Hiroaki Yamada, Hiroaki Kaneko, Tomohiko Sasaki, Tomohiro Ishii, Toshihide Tamura, Masaaki Kondo, Shin Maeda
BACKGROUND: Although Helicobacter-induced gastric inflammation is the major predisposing factor for gastric carcinogenesis, the precise mechanism by which chronic gastritis causes gastric cancer remains unclear. Intestinal and spasmolytic polypeptide-expressing metaplasia (SPEM) is considered as precancerous lesions, changes in epithelial tissue stem/progenitor cells after chronic inflammation has not been clarified yet. In this study, we utilized three-dimensional gastric epithelial cell culture systems that could form organoids, mimicking gastric epithelial layer, and characterized the changes in epithelial cells after chronic Helicobacter felis infection...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29198708/knockdown-of-laminin-%C3%AE-5-stimulates-intestinal-cell-differentiation
#18
Manon Lepage, Amira Seltana, Marie-Pier Thibault, Éric Tremblay, Jean-François Beaulieu
Interactions between cells and the extracellular matrix regulate a wide range of cell processes such as proliferation and differentiation. Laminins are major components of the basement membrane that actively participate in most biological functions via their interactions with a variety of specific cell receptors. The α5-containing laminins (LAMA5) are one of the three main types of laminins identified at the epithelial basal lamina in the adult intestine. The aim of the present study was to investigate the role of α5-containing laminins on intestinal cell proliferation and differentiation...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29196853/immunohistochemical-characterization-of-brush-cells-in-the-rat-larynx
#19
Yoshio Yamamoto, Yuko Ozawa, Takuya Yokoyama, Nobuaki Nakamuta
The immunohistochemical characteristics of brush cells in the laryngeal mucosa were examined using immunohistochemistry for various immunohistochemical cell markers including villin at the light and electron microscopic levels. Cells that were immunoreactive to villin were barrel-shaped with thick cytoplasmic processes extending toward the lumen of the laryngeal cavity. Immunoelectron microscopic observations revealed thick and short microvilli with long rootlets of microfilaments. Numerous small clear vesicles and small finger-like cytoplasmic processes were observed in the apical process and lateral membrane, respectively...
December 1, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29174217/highlights-of-the-twelfth-annual-scientific-meeting-of-the-society-of-cardiovascular-computed-tomography
#20
REVIEW
Jonathan R Weir-McCall, Todd C Villines, Leslee J Shaw, Suhny Abbara, Maros Ferencik, Koen Nieman, Stephan Achenbach, Edward Nicol
The 12th Annual Scientific Meeting of the SCCT, held from July 6 to July 9 in Washington, DC, was one of the largest to date with 724 attendants from 34 countries, 130 invited talks, 4 "Read with the Experts" sessions, 42 oral abstracts presented, 20 rapid fire posters and 164 poster presentations with the abstracts of all of these published in the JCCT. This article summarises the many themes and topics of presentation and discussion in this meeting, and the many technical advances that are likely to impact future clinical practice and feature in future meetings...
January 2018: Journal of Cardiovascular Computed Tomography
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