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https://www.readbyqxmd.com/read/27906736/an-exploratory-descriptive-study-of-registered-nurse-innovation-implications-for-levels-of-adoption
#1
Debra Polster, Dana Villines
PURPOSE: The aims of this study were to describe registered nurses' levels of personal innovativeness and registered nurses' perceived organizational innovativeness and determine the relationship between these 2 variables. BACKGROUND: There is limited research to describe the levels of innovation of nurses within a hospital. The levels of innovation can determine the likelihood of adoption of evidence-based practices at the bedside. As change agents, clinical nurse specialists can determine successful implementation strategies tailored to nurse levels of innovation...
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27893642/comparison-of-nonoperative-and-surgial-management-of-renal-trauma-can-we-predict-when-nonoperative-management-fails
#2
Marc A Bjurlin, Richard Jacob Fantus, Richard Joseph Fantus, Dana Villines
BACKGROUND: Limited data exists on risk factors for the failure of nonoperative management of renal trauma. Our study objective was to determine the incidence, salvage procedure, and risk factors for failure of nonoperative management of renal trauma. METHODS: The National Trauma Data Bank research datasets admission year 2010 - 2014 were queried for renal injury by Abbreviated Injury Score (AIS) code. Patients were stratified by interventional therapy (renal procedure code <24 hrs from admission) and nonoperative management (no surgical renal procedure <24 hrs)...
November 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27876863/intestinal-tuft-cells-regulate-the-atm-mediated-dna-damage-response-via-dclk1-dependent-mechanism-for-crypt-restitution-following-radiation-injury
#3
Parthasarathy Chandrakesan, Randal May, Nathaniel Weygant, Dongfeng Qu, William L Berry, Sripathi M Sureban, Naushad Ali, Chinthalapally Rao, Mark Huycke, Michael S Bronze, Courtney W Houchen
Crypt epithelial survival and regeneration after injury require highly coordinated complex interplay between resident stem cells and diverse cell types. The function of Dclk1 expressing tuft cells regulating intestinal epithelial DNA damage response for cell survival/self-renewal after radiation-induced injury is unclear. Intestinal epithelial cells (IECs) were isolated and purified and utilized for experimental analysis. We found that small intestinal crypts of Villin(Cre);Dclk1(f/f) mice were hypoplastic and more apoptotic 24 h post-total body irradiation, a time when stem cell survival is p53-independent...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876580/management-of-dry-mouth-assessment-of-oral-symptoms-after-use-of-a-polysaccharide-based-oral-rinse
#4
Joel B Epstein, Dana C Villines, Mabi Singh, Athena Papas
OBJECTIVE: Salivary dysfunction is associated with a range of oral/dental issues, and management of oral symptoms may improve oral function and overall quality of life. The purpose of this pilot study was to evaluate oral symptoms and function in a xerostomic population after use of a proprietary topical for dry mouth, Moisyn (Synedgen Inc., Claremont, CA), which is a polysaccharide-based product. STUDY DESIGN: A pre- and post-test survey was completed by 57 patients with xerostomia...
September 28, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27875772/hnf4%C3%AE-is-a-key-gene-that-can-generate-columnar-metaplasia-in-oesophageal-epithelium
#5
Benjamin J Colleypriest, Zoë D Burke, Leonard P Griffiths, Yu Chen, Wei-Yuan Yu, Ramiro Jover, Michael Bock, Leigh Biddlestone, Jonathan M Quinlan, Stephen G Ward, J Mark Farrant, Jonathan M W Slack, David Tosh
Barrett's metaplasia is the only known morphological precursor to oesophageal adenocarcinoma and is characterized by replacement of stratified squamous epithelium by columnar epithelium. The cell of origin is uncertain and the molecular mechanisms responsible for the change in cellular phenotype are poorly understood. We therefore explored the role of two transcription factors, Cdx2 and HNF4α in the conversion using primary organ cultures. Biopsy samples from cases of human Barrett's metaplasia were analysed for the presence of CDX2 and HNF4α...
November 19, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27856416/regulation-and-function-of-bone-morphogenetic-protein-signaling-in-colonic-injury-and-inflammation
#6
Tuo Ji, Hidehiko Takabayashi, Maria Mao, Xu Han, Xiang Xue, Jennifer C Brazil, Kathryn A Eaton, Yatrik M Shah, Andrea Todisco
The bone morphogenetic proteins (BMPs) regulate gastrointestinal homeostasis. We investigated the expression of BMP-4 and the localization and function of BMP signaling during colonic injury and inflammation. Wild type mice and mice expressing the β-galactosidase (β-gal) gene under the control of a BMP responsive element (BRE), BMP-4-β-gal/+ mice, and animals generated by crossing villin-Cre mice to mice with floxed alleles of BMP receptor 1A (villin-Cre;Bmpr1a(flox/flox)), were treated with DSS to induce colonic injury and inflammation...
November 17, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27810052/serving-to-heal-and-honored-to-serve-an-insight-into-military-cardiovascular-fellowship
#7
EDITORIAL
Emilio Fentanes, Dylan Wessman, Todd C Villines, Kevin E Steel
No abstract text is available yet for this article.
November 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27780758/scct-guidelines-for-the-performance-and-acquisition-of-coronary-computed-tomographic-angiography-a-report-of-the-society-of-cardiovascular-computed-tomography-guidelines-committee-endorsed-by-the-north-american-society-for-cardiovascular-imaging-nasci
#8
Suhny Abbara, Philipp Blanke, Christopher D Maroules, Michael Cheezum, Andrew D Choi, B Kelly Han, Mohamed Marwan, Chris Naoum, Bjarne L Norgaard, Ronen Rubinshtein, Paul Schoenhagen, Todd Villines, Jonathon Leipsic
In response to recent technological advancements in acquisition techniques as well as a growing body of evidence regarding the optimal performance of coronary computed tomography angiography (coronary CTA), the Society of Cardiovascular Computed Tomography Guidelines Committee has produced this update to its previously established 2009 "Guidelines for the Performance of Coronary CTA" (1). The purpose of this document is to provide standards meant to ensure reliable practice methods and quality outcomes based on the best available data in order to improve the diagnostic care of patients...
November 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27769115/molecular-mechanism-behind-the-fast-folding-unfolding-transitions-of-villin-headpiece-subdomain-hierarchy-and-heterogeneity
#9
Toshifumi Mori, Shinji Saito
Proteins involve motions over a wide range of spatial and temporal scales. While the large conformational changes, such as folding and functioning, are slow and appear to occur in a highly cooperative manner, how the hierarchical dynamics over different time scales play a role during these slow transitions has been of great interest over the decades. Here we study the folding mechanism of the villin headpiece subdomain (HP35) to understand the molecular mechanism behind this prototypical fast-folding protein...
November 3, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27765954/both-the-anti-and-pro-apoptotic-functions-of-villin-regulate-cell-turnover-and-intestinal-homeostasis
#10
Yaohong Wang, Sudeep P George, Swati Roy, Eric Pham, Amin Esmaeilniakooshkghazi, Seema Khurana
In the small intestine, epithelial cells are derived from stem cells in the crypts, migrate up the villus as they differentiate and are ultimately shed from the villus tips. This process of proliferation and shedding is tightly regulated to maintain the intestinal architecture and tissue homeostasis. Apoptosis regulates both the number of stem cells in the crypts as well as the sloughing of cells from the villus tips. Previously, we have shown that villin, an epithelial cell-specific actin-binding protein functions as an anti-apoptotic protein in the gastrointestinal epithelium...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754204/apsh-yi-03-essential-role-of-intestinal-epithelial-mineralocorticoid-receptor-in-the-regulation-of-sodium-absorption-and-blood-pressure
#11
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
OBJECTIVE: Recent studies have unveiled cardiovascular pathological roles of mineralocorticoid receptor (MR) in many types of cells. Although we have confirmed high expression of MR in intestinal epithelial cells (IEC), that role in progression of cardiovascular diseases is yet to be elucidated. As intestine is the first gate sensing sodium intake, MR of this organ is expected to have essential roles in blood pressure (BP) regulation. This study investigated the role of MR in IEC by using IEC-specific MR knockout mice (IEC-MR KO)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27744434/comparative-proteomics-analysis-of-mouse-habu-nephritis-models-with-and-without-unilateral-nephrectomy
#12
Lei Chen, Yang Lu, Jun Wen, Xu Wang, Lingling Wu, Di Wu, Xuefeng Sun, Bo Fu, Zhong Yin, Hongli Jiang, Xiangmei Chen
BACKGROUND/AIMS: Individuals possessing a single kidney are at greater risk of renal injury upon exposure to harmful stimuli. This study aimed to explore the pathogenesis of renal injury in glomerulonephritis with versus without unilateral nephrectomy (UNX). METHODS: Histological analysis and label-free quantitative proteomics were performed on two models-the Habu snake venom-induced glomerulonephritis model with versus without UNX (HabuU and Habu models, respectively)...
October 17, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27730620/isolation-of-actin-and-actin-binding-proteins
#13
Etsuo Yokota
Actin-binding proteins mediate and regulate the dynamics of actin and the organization of highly ordered structures of F-actin. Villin is generally expressed in plant cells and is associated with G-actin or F-actin dependent on Ca(2+) concentrations. Using a DNase I affinity column chromatography approach, the villin and the G-actin can be isolated from plant material. An outline of this method including the preparation of crude protein extract from plant material, its application on the affinity column, and the successive elution of villin with a solution containing EGTA and then of G-actin with denatured reagents is presented...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27715398/survivin-is-a-guardian-of-the-intestinal-stem-cell-niche-and-its-expression-is-regulated-by-tgf-%C3%AE
#14
Eva Martini, Evelyn Schneider, Clemens Neufert, Markus F Neurath, Christoph Becker
As an inhibitor of apoptosis (IAP) family member, Survivin is known for its role during regulation of apoptosis. More recently its function as a cell cycle regulator has become evident. Survivin was shown to play a pivotal role during embryonic development and is highly expressed in regenerative tissue as well as in many cancer types. We examined the function of Survivin during mouse intestinal organogenesis and in gut pathophysiology. We found high expression of Survivin in experimentally induced colon cancer in mice but also in colon tumors of humans...
November 2016: Cell Cycle
https://www.readbyqxmd.com/read/27697441/safety-of-direct-oral-anticoagulants-insights-from-postmarketing-studies
#15
Todd C Villines, W Frank Peacock
Direct oral anticoagulants (DOACs) have been marketed in the United States since 2010. While numerous large-scale prospective phase 3 outcomes studies have documented the effectiveness of DOACs for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, the primary safety concern with all of these drugs-as it is with the more established oral anticoagulant warfarin-is the risk of major bleeding. Postmarketing surveillance studies (PMSS) provide the opportunity to evaluate the safety of these recently approved drugs across a spectrum of patients that may be broader than those included in randomized controlled trials...
September 28, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27648810/interleukin-15-promotes-intestinal-dysbiosis-with-butyrate-deficiency-associated-with-increased-susceptibility-to-colitis
#16
Marlies Meisel, Toufic Mayassi, Hannah Fehlner-Peach, Jason C Koval, Sarah L O'Brien, Reinhard Hinterleitner, Kathryn Lesko, Sangman Kim, Romain Bouziat, Li Chen, Christopher R Weber, Sarkis K Mazmanian, Bana Jabri, Dionysios A Antonopoulos
Dysbiosis resulting in gut-microbiome alterations with reduced butyrate production are thought to disrupt intestinal immune homeostasis and promote complex immune disorders. However, whether and how dysbiosis develops before the onset of overt pathology remains poorly defined. Interleukin-15 (IL-15) is upregulated in distressed tissue and its overexpression is thought to predispose susceptible individuals to and have a role in the pathogenesis of celiac disease and inflammatory bowel disease (IBD). Although the immunological roles of IL-15 have been largely studied, its potential impact on the microbiota remains unexplored...
September 20, 2016: ISME Journal
https://www.readbyqxmd.com/read/27643161/apsh-yi-03-essential-role-of-intestinal-epithelial-mineralocorticoid-receptor-in-the-regulation-of-sodium-absorption-and-blood-pressure
#17
Toshifumi Nakamura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, Ayano Murai-Takeda, Yuko Mitsuishi, Mitsuha Morisaki, Nao Kohata, Yosuke Oshima, Gunther Schutz, Hirotaka Shibata, Hiroshi Itoh
OBJECTIVE: Recent studies have unveiled cardiovascular pathological roles of mineralocorticoid receptor (MR) in many types of cells. Although we have confirmed high expression of MR in intestinal epithelial cells (IEC), that role in progression of cardiovascular diseases is yet to be elucidated. As intestine is the first gate sensing sodium intake, MR of this organ is expected to have essential roles in blood pressure (BP) regulation. This study investigated the role of MR in IEC by using IEC-specific MR knockout mice (IEC-MR KO)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642299/myocardial-infarction-and-aortic-root-mycotic-aneurysm-complicating-aortic-valve-endocarditis-utility-of-cardiac-ct
#18
Aimee E Moores, Michael S Cahill, Todd C Villines
Aortic mycotic aneurysms are a rare but life-threatening potential complication of infective endocarditis. Rapid deterioration of the vascular wall in highly focal areas makes these pseudoaneurysms particularly prone to rupture, resulting in uncontrolled aortic hemorrhage. While computed tomography angiography (CTA) is the imaging modality of choice for the evaluation of mycotic aneurysms, it is not routinely performed in patients with known or suspected infective endocarditis (IE). However, current valvular heart disease guidelines support the use of cardiac CTA in cases of IE and suspected perivalvular extension when there is inadequate or ambiguous visualization on echocardiography...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27633532/studying-the-role-of-cooperative-hydration-in-stabilizing-folded-protein-states
#19
David J Huggins
Understanding and modelling protein folding remains a key scientific and engineering challenge. Two key questions in protein folding are (1) why many proteins adopt a folded state and (2) how these proteins transition from the random coil ensemble to a folded state. In this paper we employ molecular dynamics simulations to address the first of these questions. Computational methods are well-placed to address this issue due to their ability to analyze systems at atomic-level resolution. Traditionally, the stability of folded proteins has been ascribed to the balance of two types of intermolecular interactions: hydrogen-bonding interactions and hydrophobic contacts...
December 2016: Journal of Structural Biology
https://www.readbyqxmd.com/read/27617340/refined-parameterization-of-nonbonded-interactions-improves-conformational-sampling-and-kinetics-of-protein-folding-simulations
#20
Jejoong Yoo, Aleksei Aksimentiev
Recent advances in computational technology have enabled brute-force molecular dynamics (MD) simulations of protein folding using physics-based molecular force fields. The extensive sampling of protein conformations afforded by such simulations revealed, however, considerable compaction of the protein conformations in the unfolded state, which is inconsistent with experiment. Here, we show that a set of surgical corrections to nonbonded interactions between amine nitrogen-carboxylate oxygen and aliphatic carbon-carbon atom pairs can considerably improve the realism of protein folding simulations...
October 6, 2016: Journal of Physical Chemistry Letters
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