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https://www.readbyqxmd.com/read/28938744/an-improved-ivm-method-for-cumulus-oocyte-complexes-from-small-follicles-in-polycystic-ovary-syndrome-patients-enhances-oocyte-competence-and-embryo-yield
#1
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#2
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938721/the-draft-genome-sequence-of-a-desert-tree-populus-pruinosa
#3
Wenlu Yang, Kun Wang, Jian Zhang, Jianchao Ma, Jianquan Liu, Tao Ma
Populus pruinosa is a large tree that grows in deserts and shows distinct differences in both morphology and adaptation compared to its sister species, P. euphratica. Here we present a draft genome sequence for P. pruinosa and examine genomic variations between the 2 species. A total of 60 Gb of clean reads from whole-genome sequencing of a P. pruinosa individual were generated using the Illumina HiSeq2000 platform. The assembled genome is 479.3 Mb in length, with an N50 contig size of 14.0 kb and a scaffold size of 698...
September 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28938682/mental-health-of-the-old-and-new-generation-migrant-workers-in-china-who-are-at-greater-risk-for-psychological-distress
#4
Bao-Liang Zhong, Sandra S M Chan, Tie-Bang Liu, Dong Jin, Chi-Yi Hu, Helen F K Chiu
Rural-to-urban migrant workers (MWs) are a large vulnerable population in China and, recently, the new-generation MWs (those born in 1980 or later) have become the majority of this population. Examining difference in the epidemiology of poor mental health between the new- and old-generation (those born before 1980) MWs would facilitate mental health promotion efforts. However, very few related studies are available and they produced conflicting findings. This study investigated intergenerational difference in prevalence and correlates of psychological distress (PD) in MWs...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938604/inflammation-and-stem-markers-association-to-pim1-pim2-kinase-induced-tumors-in-breast-and-uterus
#5
Manuel-Pedro Jiménez-García, Antonio Lucena-Cacace, María-José Robles-Frías, Irene Ferrer, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of Ser/Thr kinase proteins has been implicated in tumorigenesis at different levels. PIM proteins are overexpressed in several tumor types and have been associated with chemoresistance. However, their role in hormone-dependent female tissues has not been explored, especially in the uterus, breast and ovary. We generated conditional transgenic mice with confined expression of human PIM1 or PIM2 genes in these tissues. We characterized the tumoral response to these genetic alterations corroborating their role as oncogenes since they induce hyperproliferation in all tissues and tumors in mammary gland and uterus...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938498/-loudness-optimized-registration-of-compound-action-potential-in-cochlear-implant-recipients
#6
Klaus Berger, Thomas Hocke, Horst Hessel
Background Postoperative measurements of compound action potentials are not always possible due to the insufficient acceptance of the CI-recipients. This study investigated the impact of different parameters on the acceptance of the measurements. Methods Compound action potentials of 16 CI recipients were measured with different pulse-widths. Recipients performed a loudness rating at the potential thresholds with the different sequences. Results Compound action potentials obtained with higher pulse-widths were rated softer than those obtained with smaller pulse-widths...
September 22, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28938475/modeling-the-sex-differences-and-inter-individual-variability-in-the-activity-of-the-hypothalamic-pituitary-adrenal-axis
#7
Rohit T Rao, Ioannis P Androulakis
Significant sex differences exist in the activity of the hypothalamic-pituitary-adrenal (HPA) axis. These differences are thought to contribute to the disparity in the prevalence of various autoimmune and infectious diseases between males and females. We use a mathematical model of the HPA axis to evaluate the hypothesis that differential sensitivity and negative feedback of the HPA axis network are causal factors for the observed sex differences in its activity. In doing so, we implicitly account for the differential influence of gonadal hormones on the HPA axis...
August 31, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938472/dopamine-neuron-restricted-leptin-receptor-lepr-signaling-reduces-some-aspects-of-food-reward-but-exacerbates-the-obesity-of-lepr-deficient-male-mice
#8
Maggie C Evans, Greg M Anderson
The contribution of leptin-induced modulation of dopamine neurons to feeding behavior and energy homeostasis remains unclear. Midbrain dopamine neurons regulate the reward value of food, and direct leptin administration to the midbrain reduces food intake. However, selective deletion of leptin receptors (Lepr) from dopamine neurons has no effect on body weight, food intake or hedonic responses, either suggesting leptin acts indirectly or demonstrating sufficient compensation occurs to mask any direct leptin-dopamine effects...
August 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938464/sex-differences-in-steroid-receptor-co-expression-and-circadian-timed-activation-of-kisspeptin-and-rfrp-3-neurons-may-contribute-to-the-sexually-dimorphic-basis-of-the-lh-surge
#9
Matthew C Poling, Elena Y Luo, Alexander S Kauffman
In rodents, the ovulation-inducing LH surge is sexually dimorphic, occurring only in females, but the reasons for this sex difference are unclear. Two neuropeptides, kisspeptin and RFRP-3, are hypothesized to regulate the GnRH/LH surge. In females, both these systems show circadian changes coincident with the LH surge, but whether males show similar temporal changes under comparable hormonal conditions is unknown. Here, we evaluated circadian time (CT)-dependent changes in gene expression and neuronal activation of Kiss1 and Rfrp neurons of female and male mice given identical LH surge-inducing estrogen regimens...
August 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938238/impact-of-diabetes-mellitus-on-5-year-clinical-outcomes-in-patients-with-chronic-total-occlusion-lesions
#10
Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Min Suk Shim, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Diabetes mellitus (DM) is a major predictor of cardiovascular morbidity and mortality. However, there are limited data on the impact of DM in patients who have chronic total occlusion (CTO) lesion on long-term outcomes. PATIENTS AND METHODS: A total of 822 CTO patients who underwent coronary angiography, treated by either percutaneous coronary intervention or optimal medical therapy, were enrolled and divided into two groups: (i) diabetic group (n=363) and (ii) nondiabetic group (n=459)...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28938171/behavior-of-radioactive-cesium-during-incineration-of-radioactively-contaminated-wastes-from-decontamination-activities-in-fukushima
#11
Hiroshi Fujiwara, Hidetoshi Kuramochi, Kazutaka Nomura, Tomoharu Maeseto, Masahiro Osako
Large volumes of decontamination wastes (DW) generated by off-site decontamination activities in Fukushima Prefecture have been incinerated since 2015. The behavior of radioactive cesium during incineration of DW was investigated at a working incineration plant. The incineration discharged bottom ash (BA) and fly ash (FA) with similar levels of radiocesium, and the leachability of the radiocesium from both types of ash was very low (<1%). These results are significantly different from those obtained for the incineration of contaminated municipal solid waste (CMSW) reported in earlier studies...
September 18, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28938032/efficacy-of-sealing-agents-on-preload-maintenance-of-screw-retained-implant-supported-prostheses
#12
Camila Berbel Seloto, Henrico Badaoui Strazzi Sahyon, Paulo Henrique Dos Santos, Juliana Aparecida Delben, Wirley Gonçalves Assunção
PURPOSE: The aim of this study was to evaluate the effect of sealing agents on preload maintenance of screw joints. MATERIALS AND METHODS: A total of four groups (n = 10 in each group) of abutment/implant systems, including external hexagon implants and antirotational UCLA abutments with a metallic collar in cobalt-chromium alloy, were assessed. In the control group (CG), no sealing agent was used at the abutment screw/implant interface. In the other groups, three different sealing agents were used at the abutment screw/implant interface: anaerobic sealing agent for medium torque (ASMT), anaerobic sealing agent for high torque (ASHT), and cyanoacrylate-based bonding agent (CYAB)...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937992/efficient-generation-of-mutations-mediated-by-crispr-cas9-in-the-hairy-root-transformation-system-of-brassica-carinata
#13
Thomas W Kirchner, Markus Niehaus, Thomas Debener, Manfred K Schenk, Marco Herde
A protocol for the induction of site-directed deletions and insertions in the genome of Brassica carinata with CRISPR is described. The construct containing the Cas9 nuclease and the guide RNA (gRNA) was delivered by the hairy root transformation technique, and a successful transformation was monitored by GFP fluorescence. PAGE analysis of an amplified region, presumably containing the deletions and insertions, demonstrated up to seven different indels in one transgenic root and in all analyzed roots a wildtype allele of the modified gene was not detectable...
2017: PloS One
https://www.readbyqxmd.com/read/28937977/phase-changes-in-neuronal-postsynaptic-spiking-due-to-short-term-plasticity
#14
Mark D McDonnell, Bruce P Graham
In the brain, the postsynaptic response of a neuron to time-varying inputs is determined by the interaction of presynaptic spike times with the short-term dynamics of each synapse. For a neuron driven by stochastic synapses, synaptic depression results in a quite different postsynaptic response to a large population input depending on how correlated in time the spikes across individual synapses are. Here we show using both simulations and mathematical analysis that not only the rate but the phase of the postsynaptic response to a rhythmic population input varies as a function of synaptic dynamics and synaptic configuration...
September 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28937972/a-risk-factor-analysis-of-cognitive-impairment-in-elderly-patients-with-chronic-diseases-in-a-chinese-population
#15
Ye Li, Xiang Fang, Wei-Gang Zhao, Yan Chen, Shi-Lian Hu
BACKGROUND This study analyzed the risk factors of cognitive impairment (CI) in elderly patients with chronic diseases. MATERIAL AND METHODS In total of 385 elderly patients with chronic diseases were selected and assigned into CI and normal groups. The activities of daily living (ADL), global deterioration scale (GDS), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA), patient-generated subjective global assessment (PG-SGA), and mini nutritional assessment (MNA) were performed to analyze the differences between the 2 groups...
September 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28937832/aberrant-plasticity-in-the-hippocampus-after-neonatal-seizures
#16
Xiaoqian Zhang, Huiling Qu, Ying Wang, Shanshan Zhao, Ting Xiao, Chuansheng Zhao, Weiyu Teng
Neonatal seizures are the most frequent type of neurological disorder and those newborn babies that experience seizures carry an increased risk of epileptogenesis and other long-term morbidities. The newly generated dentate granule cells (DGCs) integrate functionally into the mature hippocampal network by continuously forming connections with their targets but this process of adult neurogenesis can be influenced by seizures. When compared to adult seizures, neonatal seizures may exert different effects on neurogenesis due to the high resistance of the newborn's neurons to cell death combined with the inherent high sensitivity to seizures in the immature brain...
September 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28937814/comparative-analyses-of-phenotypic-trait-covariation-within-and-among-populations
#17
Kathryn S Peiman, Beren W Robinson
Many morphological, behavioral, physiological, and life-history traits covary across the biological scales of individuals, populations, and species. However, the processes that cause traits to covary also change over these scales, challenging our ability to use patterns of trait covariance to infer process. Trait relationships are also widely assumed to have generic functional relationships with similar evolutionary potentials, and even though many different trait relationships are now identified, there is little appreciation that these may influence trait covariation and evolution in unique ways...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937754/bi-functional-elastin-like-polypeptide-nanoparticles-bind-rapamycin-and-integrins-and-suppress-tumor-growth-in-vivo
#18
Jugal P Dhandhukia, Pu Shi, Santosh Peddi, Zhe Li, Suhaas Rayudu Aluri, Yaping Ju, Dab Brill, Wan Wang, Siti Janib, Yi-An Lin, Shuanglong Liu, Honggang Cui, John Andrew MacKay
Recombinant protein-polymer scaffolds such as Elastin-Like Polypeptides (ELPs) offer drug delivery opportunities including biocompatibility, monodispersity, and multi-functionality. We recently reported that fusion of FK-506 binding protein 12 (FKBP) to an ELP nanoparticle (FSI) increases rapamycin (Rapa) solubility, suppresses growth of breast cancer xenografts, and reduces side-effects observed with free drug controls. This new report significantly advances this carrier strategy by demonstrating the co-assembly of two different ELP diblock copolymers containing drug-loading and tumor-targeting domains...
September 22, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28937663/a-metallo-dna-nanowire-with-uninterrupted-one-dimensional-silver-array
#19
Jiro Kondo, Yoshinari Tada, Takenori Dairaku, Yoshikazu Hattori, Hisao Saneyoshi, Akira Ono, Yoshiyuki Tanaka
The double-helix structure of DNA, in which complementary strands reversibly hybridize to each other, not only explains how genetic information is stored and replicated, but also has proved very attractive for the development of nanomaterials. The discovery of metal-mediated base pairs has prompted the generation of short metal-DNA hybrid duplexes by a bottom-up approach. Here we describe a metallo-DNA nanowire-whose structure was solved by high-resolution X-ray crystallography-that consists of dodecamer duplexes held together by four different metal-mediated base pairs (the previously observed C-Ag-C, as well as G-Ag-G, G-Ag-C and T-Ag-T) and linked to each other through G overhangs involved in interduplex G-Ag-G...
October 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28937646/effects-of-liposomes-contained-in-thermosensitive-hydrogels-as-biomaterials-useful-in-neural-tissue-engineering
#20
Yusser Olguín, Cristian Campos, Javiera Catalán, Luís Velásquez, Fernando Osorio, Iván Montenegro, Alejandro Madrid, Cristian Acevedo
Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes...
September 22, 2017: Materials
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