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https://www.readbyqxmd.com/read/29708300/gaba-tea-attenuates-cardiac-apoptosis-in-spontaneously-hypertensive-rats-shr-by-enhancing-pi3k-akt-mediated-survival-pathway-and-suppressing-bax-bak-dependent-apoptotic-pathway
#1
Bih-Cheng Chen, Meng-Yu Hung, Hsueh-Fang Wang, Li-Jen Yeh, Sudhir Pandey, Ray-Jade Chen, Ruey-Lin Chang, Vijaya Padma Viswanadha, Kuan-Ho Lin, Chih-Yang Huang
Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male SHR at eight weeks of age, 200 g were divided into six groups. One group was fed water as a control group. Other rats were administered one of the following treatments: GABA tea at dose 150 and 300 mg/kg/day as low GABA tea (LGT) and high GABA tea (HGT) groups, respectively, pure GABA at dose 150 and 300 mg/kg/day as LG and HG groups, respectively, green tea (GT) as control of LGT and HGT groups...
April 30, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29705350/mirna-150-5p-associate-with-antihypertensive-effect-of-epigallocatechin-3-gallate-revealed-by-aorta-mirnome-analysis-of-spontaneously-hypertensive-rat
#2
Bing-Jun Qian, Chong-Chong Tian, Xiao-Hong Ling, Li-Li Yu, Feng-Yun Ding, Jiang-Hua Huo, Liu-Cun Zhu, Yao-Lin Wen, Jian-Hua Zhang, Pu Jing
AIMS: The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism. MAIN METHODS: The pharmacokinetic behaviors of EGCG and epigallocatechin (EGC) in Sprague-Dawley rats were analyzed by HPLC and DRUG AND STATISTICS software...
June 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29605251/protein-engineering-regulatory-perspectives-of-stearoyl-coa-desaturase
#3
REVIEW
Shagufta Kamal, Ayesha Saleem, Saima Rehman, Ismat Bibi, Hafiz M N Iqbal
Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological membrane. Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively. From the biological viewpoint, hyperexpression of SCD1 cause many metabolic disorders including obesity, insulin resistance, hypertension, and hypertriglyceridemia, etc...
July 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29225315/comparison-of-the-effects-of-three-tea-cultivars-camellia-sinensis-l-on-nitric-oxide-production-and-aortic-soluble-guanylate-cyclase-expression-in-high-salt-diet-fed-spontaneously-hypertensive-rats
#4
Sachiko Nomura, Manami Monobe, Kaori Ema, Mari Maeda-Yamamoto, Atsushi Nesumi
Studies have suggested that the consumption of green tea reduces the risk of cardiovascular diseases. Although epigallocatechin gallate (EGCG) is the best studied active substance characteristic of green tea, previous results on EGCG do not appear sufficient to explain completely the mechanism of cardiovascular protection by green tea. Therefore, we investigated the effect of three different tea cultivars, "Yabukita," "Sofu," and "Sunrouge," which have characteristic flavonoid compositions, on the nitric oxide (NO) production and the related protein expression in the aorta of spontaneously hypertensive rats (SHRs) fed a high-salt diet...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29204902/diet-and-risk-of-diabetic-retinopathy-a-systematic-review
#5
REVIEW
Courtney Dow, Francesca Mancini, Kalina Rajaobelina, Marie-Christine Boutron-Ruault, Beverley Balkau, Fabrice Bonnet, Guy Fagherazzi
Diabetic retinopathy is a microvascular complication of diabetes that threatens all individuals with diabetes, leading to vision loss or blindness if left untreated. It is frequently associated with diabetic macular edema, which can occur at any point during the development of diabetic retinopathy. The key factors known to lead to its development include hyperglycemia, hypertension, and the duration of diabetes. Though the diet is important in the development of diabetes, its role in diabetic retinopathy has not been clearly identified...
February 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29188858/modest-overweight-and-healthy-dietary-habits-reduce-risk-of-dementia-a-nationwide-survey-in-taiwan
#6
C-Y Lee, Y Sun, H-J Lee, T-F Chen, P-N Wang, K-N Lin, L-Y Tang, C-C Lin, M-J Chiu
BACKGROUND: Evidence of the associations of dietary habits and body mass index with dementia is inconsistent and limited in East Asian countries. OBJECTIVE: We aim to explore the associations of dietary habits and body mass index with the odds of dementia. DESIGN: Cross-sectional observational study. SETTING: A nationwide, population-based, door-to-door, in-person survey. PARTICIPANTS: Selected by computerized random sampling from all 19 counties in Taiwan...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29080460/chlorogenic-acid-cga-a-pharmacological-review-and-call-for-further-research
#7
REVIEW
Muhammad Naveed, Veghar Hejazi, Muhammad Abbas, Asghar Ali Kamboh, Ghulam Jilany Khan, Muhammad Shumzaid, Fawwad Ahmad, Daryoush Babazadeh, Xia FangFang, Faezeh Modarresi-Ghazani, Li WenHua, Zhou XiaoHui
Phenolic acids have recently gained substantial attention due to their various practical, biological and pharmacological effects. Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-CQA as per guidelines of IUPAC. It is one of the most available acids among phenolic acid compounds which can be naturally found in green coffee extracts and tea. CGA is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension, free radicals scavenger and a central nervous system (CNS) stimulator...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28990942/-herbal-supplement-usage-in-cardiac-patients
#8
Neslihan Pınar, Meyli Topaloğlu, Cahit Özer, Harun Alp
OBJECTIVE: Complementary and alternative medicine (CAM) has become more and more widespread around the world. CAM is a broad term that refers to all medical healthcare services, methods, and practices that are not part of standard medical care, as well as the accompanying theories and beliefs. The aim of the present study was to investigate the use of herbal medicinal products in cardiac patients, as well as the methods of administration of the products. METHODS: This descriptive cross-sectional study included 199 patients aged over 18 years who were hospitalized in the Defne Hospital department of cardiology and volunteered to participate in a 20-item survey between April 2016 and June 2016...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28726273/epigallocatechin-gallate-enhances-treatment-efficacy-of-oral-nifedipine-against-pregnancy-induced-severe-pre-eclampsia-a-double-blind-randomized-and-placebo-controlled-clinical-study
#9
D-D Shi, J-J Guo, L Zhou, N Wang
WHAT IS KNOWN AND OBJECTIVE: Oral nifedipine is commonly used to treat pre-eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre-eclampsia. METHODS: A total of 350 pregnant women with severe pre-eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG)...
February 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28586744/protective-effects-of-green-tea-on-olanzapine-induced-metabolic-syndrome-in-rats
#10
Bibi Marjan Razavi, Fariba Lookian, Hossein Hosseinzadeh
Atypical antipsychotics particularly olanzapine are associated with obesity and serious metabolic disturbances. As green tea (Camellia sinensis) is generally associated with beneficial effects on obesity and other metabolic disturbances, this study was undertaken to evaluate the effect of green tea aqueous extract (GTAE) on olanzapine induced weight gain and metabolic abnormalities in rats. Male Wistar rats were divided into eight groups: control, olanzapine (5mg/kg/day, IP.), GTAE (25, 50 and 100mg/kg/day, IP...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28584836/effect-of-green-tea-on-metabolic-and-hormonal-aspect-of-polycystic-ovarian-syndrome-in-overweight-and-obese-women-suffering-from-polycystic-ovarian-syndrome-a-clinical-trial
#11
Hatav Gasemi Tehrani, Maryam Allahdadian, Farzane Zarre, Hanie Ranjbar, Fateme Allahdadian
BACKGROUND AND OBJECTIVE: Polycystic ovarian syndrome (PCOS) is the common cause of Oligo-ovulation. This syndrome causes long-term metabolic issues as well as increase the risk of diabetes type 2, hypertension, dyslipidemia, and cardiovascular disease. The current research aimed to study the effect of green tea on weight and hormonal changes of women suffering from PCOS. METHODS: This two group, double-blind, randomized clinical trial was conducted in Isfahan city...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28541356/food-and-plant-bioactives-for-reducing-cardiometabolic-disease-risk-an-evidence-based-approach
#12
REVIEW
Arrigo F G Cicero, Federica Fogacci, Alessandro Colletti
Cardiovascular diseases (CVDs) are one of the major causes of mortality and disability in Western countries. Prevention is known to be the cornerstone to lessen the incidence of CVDs and also to reduce the economic burden of both the citizen and the healthcare system. "Interventional medicine" certainly puts lifestyle modification as the first therapeutic step, including a healthy diet and physical activity. Secondly, a large body of research individuated a number of food and plant bioactives, which are potentially efficacious in preventing and reducing some highly prevalent CV risk factors, such as hypercholesterolemia, hypertension, vascular inflammation and vascular compliance...
June 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28326006/effects-of-green-tea-supplementation-on-inflammation-markers-antioxidant-status-and-blood-pressure-in-nacl-induced-hypertensive-rat-model
#13
Monika Szulińska, Marta Stępień, Matylda Kręgielska-Narożna, Joanna Suliburska, Damian Skrypnik, Monika Bąk-Sosnowska, Magdalena Kujawska-Łuczak, Małgorzata Grzymisławska, Paweł Bogdański
Background: Recent studies indicate the important role of chronic inflammation and oxidative stress in the pathogenesis of hypertension. Green tea, due to the high content of catechins, shows high antioxidant activity. Objective: To determine the effect of supplementation with green tea extract on the blood pressure, on the concentration of selected parameters of inflammation and antioxidant status in the model of high-sodium-diet induced hypertension. Design: The study lasted 42 days. The experimental population consisted of 30 rats...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28251341/coffee-tea-caffeine-and-risk-of-hypertension-the-singapore-chinese-health-study
#14
Choy-Lye Chei, Julian Kenrick Loh, Avril Soh, Jian-Min Yuan, Woon-Puay Koh
PURPOSE: The relationship between coffee and tea, and risk of hypertension remains controversial in Western populations. We investigated these associations in an Asian population. METHODS: The Singapore Chinese Health Study is a population-based prospective cohort that recruited 63,257 Chinese aged 45-74 years and residing in Singapore from 1993 to 1998. Information on consumption of coffee, tea, and other lifestyle factors was collected at baseline, and self-reported physician-diagnosed hypertension was assessed during two follow-up interviews (1999-2004, 2006-2010)...
June 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/28013477/inhibition-of-pro-active-mmp-2-by-green-tea-catechins-and-prediction-of-their-interaction-by-molecular-docking-studies
#15
Animesh Chowdhury, Suman Kumar Nandy, Jaganmay Sarkar, Tapati Chakraborti, Sajal Chakraborti
Matrix metalloproteinases (MMPs) play a crucial role in developing different types of lung diseases, e.g., pulmonary arterial hypertension (PAH). Green tea polyphenolic catechins such as EGCG and ECG have been shown to ameliorate various types of diseases including PAH. Our present study revealed that among the four green tea catechins (EGCG, ECG, EC, and EGC), EGCG and ECG inhibit pro-/active MMP-2 activities in pulmonary artery smooth muscle cell (PASMC) culture supernatant. Based on the above, we investigated the interactions of pro-/active MMP-2 with the green tea catechins by computational methods...
March 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28005704/the-antioxidant-effects-of-green-tea-reduces-blood-pressure-and-sympathoexcitation-in-an-experimental-model-of-hypertension
#16
Michelle L Garcia, Roberto B Pontes, Erika E Nishi, Flávia K Ibuki, Vanessa Oliveira, Alexandra C H Sawaya, Patrícia O Carvalho, Fernando N Nogueira, Maria do Carmo Franco, Ruy R Campos, Lila M Oyama, Cássia T Bergamaschi
BACKGROUND: Oxidative stress is a key mediator in the maintenance of sympathoexcitation and hypertension in human and experimental models. Green tea is widely known to be potent antioxidant. OBJECTIVE: We aimed to evaluate the effects of green tea in a model of hypertension. METHODS: Hypertension was induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks] in male Wistar rats...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27941615/mechanisms-of-body-weight-reduction-by-black-tea-polyphenols
#17
REVIEW
Haibo Pan, Ying Gao, Youying Tu
Obesity is one of the most common nutritional diseases worldwide. This disease causes health problems, such as dyslipidemia, hyperglycemia, hypertension and inflammation. There are drugs used to inhibit obesity. However, they have serious side effects outweighing their beneficial effects. Black tea, commonly referred to as "fermented tea", has shown a positive effect on reducing body weight in animal models. Black tea polyphenols are the major components in black tea which reduce body weight. Black tea polyphenols are more effective than green tea polyphenols...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#18
REVIEW
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27797683/short-term-effects-of-green-tea-on-blood-pressure-endothelial-function-and-metabolic-profile-in-obese-prehypertensive-women-a-crossover-randomized-clinical-trial
#19
Lívia de P Nogueira, José Firmino Nogueira Neto, Márcia R S T Klein, Antonio F Sanjuliani
BACKGROUND: Green tea consumption has been inversely associated with cardiovascular disease (CVD) in epidemiological studies. Although some interventional trials suggest that green tea has beneficial effects on CVD risk factors, such as hypertension and obesity, others have failed to show such benefits. AIMS: To evaluate the short-term effects of green tea on blood pressure, endothelial function, metabolic profile, and inflammatory activity in obese prehypertensive women...
February 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27777793/visual-impairment-among-older-adults-in-a-rural-community-in-eastern-china
#20
Chen-Wei Pan, Deng-Juan Qian, Hong-Peng Sun, Qinghua Ma, Yong Xu, E Song
Purpose. To determine the prevalence, causes, and associations of visual impairment (VI) among participants aged 60 years or older in a rural community in China. Methods. A community-based survey was undertaken in a rural town located in Eastern China and 4579 people aged 60 years or older participated in the study. Presenting visual acuity was assessed using a Snellen chart with tumbling-E optotypes and anterior segment was examined using a slit-lamp. VI was defined as presenting VA <6/18 and it included moderate VI (<6/18 to 6/60) and blindness (<6/60)...
2016: Journal of Ophthalmology
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