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https://www.readbyqxmd.com/read/28726273/epigallocatechin-gallate-enhances-treatment-efficacy-of-oral-nifedipine-against-pregnancy-induced-severe-pre-eclampsia-a-double-blind-randomized-and-placebo-controlled-clinical-study
#1
D-D Shi, J-J Guo, L Zhou, N Wang
WHAT IS KNOWN AND OBJECTIVE: Oral nifedipine is commonly used to treat pre-eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre-eclampsia. METHODS: A total of 350 pregnant women with severe pre-eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG)...
July 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28586744/protective-effects-of-green-tea-on-olanzapine-induced-metabolic-syndrome-in-rats
#2
Bibi Marjan Razavi, Fariba Lookian, Hossein Hosseinzadeh
Atypical antipsychotics particularly olanzapine are associated with obesity and serious metabolic disturbances. As green tea (Camellia sinensis) is generally associated with beneficial effects on obesity and other metabolic disturbances, this study was undertaken to evaluate the effect of green tea aqueous extract (GTAE) on olanzapine induced weight gain and metabolic abnormalities in rats. Male Wistar rats were divided into eight groups: control, olanzapine (5mg/kg/day, IP.), GTAE (25, 50 and 100mg/kg/day, IP...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28584836/effect-of-green-tea-on-metabolic-and-hormonal-aspect-of-polycystic-ovarian-syndrome-in-overweight-and-obese-women-suffering-from-polycystic-ovarian-syndrome-a-clinical-trial
#3
Hatav Gasemi Tehrani, Maryam Allahdadian, Farzane Zarre, Hanie Ranjbar, Fateme Allahdadian
BACKGROUND AND OBJECTIVE: Polycystic ovarian syndrome (PCOS) is the common cause of Oligo-ovulation. This syndrome causes long-term metabolic issues as well as increase the risk of diabetes type 2, hypertension, dyslipidemia, and cardiovascular disease. The current research aimed to study the effect of green tea on weight and hormonal changes of women suffering from PCOS. METHODS: This two group, double-blind, randomized clinical trial was conducted in Isfahan city...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28541356/food-and-plant-bioactives-for-reducing-cardiometabolic-disease-risk-an-evidence-based-approach
#4
REVIEW
Arrigo F G Cicero, Federica Fogacci, Alessandro Colletti
Cardiovascular diseases (CVDs) are one of the major causes of mortality and disability in Western countries. Prevention is known to be the cornerstone to lessen the incidence of CVDs and also to reduce the economic burden of both the citizen and the healthcare system. "Interventional medicine" certainly puts lifestyle modification as the first therapeutic step, including a healthy diet and physical activity. Secondly, a large body of research individuated a number of food and plant bioactives, which are potentially efficacious in preventing and reducing some highly prevalent CV risk factors, such as hypercholesterolemia, hypertension, vascular inflammation and vascular compliance...
May 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28326006/effects-of-green-tea-supplementation-on-inflammation-markers-antioxidant-status-and-blood-pressure-in-nacl-induced-hypertensive-rat-model
#5
Monika Szulińska, Marta Stępień, Matylda Kręgielska-Narożna, Joanna Suliburska, Damian Skrypnik, Monika Bąk-Sosnowska, Magdalena Kujawska-Łuczak, Małgorzata Grzymisławska, Paweł Bogdański
Background: Recent studies indicate the important role of chronic inflammation and oxidative stress in the pathogenesis of hypertension. Green tea, due to the high content of catechins, shows high antioxidant activity. Objective: To determine the effect of supplementation with green tea extract on the blood pressure, on the concentration of selected parameters of inflammation and antioxidant status in the model of high-sodium-diet induced hypertension. Design: The study lasted 42 days. The experimental population consisted of 30 rats...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28251341/coffee-tea-caffeine-and-risk-of-hypertension-the-singapore-chinese-health-study
#6
Choy-Lye Chei, Julian Kenrick Loh, Avril Soh, Jian-Min Yuan, Woon-Puay Koh
PURPOSE: The relationship between coffee and tea, and risk of hypertension remains controversial in Western populations. We investigated these associations in an Asian population. METHODS: The Singapore Chinese Health Study is a population-based prospective cohort that recruited 63,257 Chinese aged 45-74 years and residing in Singapore from 1993 to 1998. Information on consumption of coffee, tea, and other lifestyle factors was collected at baseline, and self-reported physician-diagnosed hypertension was assessed during two follow-up interviews (1999-2004, 2006-2010)...
March 1, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28013477/inhibition-of-pro-active-mmp-2-by-green-tea-catechins-and-prediction-of-their-interaction-by-molecular-docking-studies
#7
Animesh Chowdhury, Suman Kumar Nandy, Jaganmay Sarkar, Tapati Chakraborti, Sajal Chakraborti
Matrix metalloproteinases (MMPs) play a crucial role in developing different types of lung diseases, e.g., pulmonary arterial hypertension (PAH). Green tea polyphenolic catechins such as EGCG and ECG have been shown to ameliorate various types of diseases including PAH. Our present study revealed that among the four green tea catechins (EGCG, ECG, EC, and EGC), EGCG and ECG inhibit pro-/active MMP-2 activities in pulmonary artery smooth muscle cell (PASMC) culture supernatant. Based on the above, we investigated the interactions of pro-/active MMP-2 with the green tea catechins by computational methods...
March 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28005704/the-antioxidant-effects-of-green-tea-reduces-blood-pressure-and-sympathoexcitation-in-an-experimental-model-of-hypertension
#8
Michelle L Garcia, Roberto B Pontes, Erika E Nishi, Flávia K Ibuki, Vanessa Oliveira, Alexandra C H Sawaya, Patrícia O Carvalho, Fernando N Nogueira, Maria do Carmo Franco, Ruy R Campos, Lila M Oyama, Cássia T Bergamaschi
BACKGROUND: Oxidative stress is a key mediator in the maintenance of sympathoexcitation and hypertension in human and experimental models. Green tea is widely known to be potent antioxidant. OBJECTIVE: We aimed to evaluate the effects of green tea in a model of hypertension. METHODS: Hypertension was induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks] in male Wistar rats...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27941615/mechanisms-of-body-weight-reduction-by-black-tea-polyphenols
#9
REVIEW
Haibo Pan, Ying Gao, Youying Tu
Obesity is one of the most common nutritional diseases worldwide. This disease causes health problems, such as dyslipidemia, hyperglycemia, hypertension and inflammation. There are drugs used to inhibit obesity. However, they have serious side effects outweighing their beneficial effects. Black tea, commonly referred to as "fermented tea", has shown a positive effect on reducing body weight in animal models. Black tea polyphenols are the major components in black tea which reduce body weight. Black tea polyphenols are more effective than green tea polyphenols...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27852126/traditional-chinese-medicine-food-therapy-and-hypertension-control-a-narrative-review-of-chinese-literature
#10
REVIEW
Ping Zou
Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27797683/short-term-effects-of-green-tea-on-blood-pressure-endothelial-function-and-metabolic-profile-in-obese-prehypertensive-women-a-crossover-randomized-clinical-trial
#11
Lívia de P Nogueira, José Firmino Nogueira Neto, Márcia R S T Klein, Antonio F Sanjuliani
BACKGROUND: Green tea consumption has been inversely associated with cardiovascular disease (CVD) in epidemiological studies. Although some interventional trials suggest that green tea has beneficial effects on CVD risk factors, such as hypertension and obesity, others have failed to show such benefits. AIMS: To evaluate the short-term effects of green tea on blood pressure, endothelial function, metabolic profile, and inflammatory activity in obese prehypertensive women...
February 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27777793/visual-impairment-among-older-adults-in-a-rural-community-in-eastern-china
#12
Chen-Wei Pan, Deng-Juan Qian, Hong-Peng Sun, Qinghua Ma, Yong Xu, E Song
Purpose. To determine the prevalence, causes, and associations of visual impairment (VI) among participants aged 60 years or older in a rural community in China. Methods. A community-based survey was undertaken in a rural town located in Eastern China and 4579 people aged 60 years or older participated in the study. Presenting visual acuity was assessed using a Snellen chart with tumbling-E optotypes and anterior segment was examined using a slit-lamp. VI was defined as presenting VA <6/18 and it included moderate VI (<6/18 to 6/60) and blindness (<6/60)...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27668533/inhibition-of-mmp-9-by-green-tea-catechins-and-prediction-of-their-interaction-by-molecular-docking-analysis
#13
Jaganmay Sarkar, Suman Kumar Nandy, Animesh Chowdhury, Tapati Chakraborti, Sajal Chakraborti
Green tea polyphenolic catechins have been shown to prevent various types of diseases such as pulmonary hypertension (PAH), cancer and cardiac and neurological disorders. Matrix metalloproteinases (MMPs) play an important role in the development of PAH. The present study demonstrated that among the four green tea catechins (EGCG, ECG, EC and EGC), EGCG and ECG inhibit pro-/active MMP-9 activities in pulmonary artery smooth muscle cell culture supernatant. Based on the above, we investigated the interactions of pro-/active MMP-9 with the green tea catechins by computational methods...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27659729/chronic-infusion-of-epigallocatechin-3-o-gallate-into-the-hypothalamic-paraventricular-nucleus-attenuates-hypertension-and-sympathoexcitation-by-restoring-neurotransmitters-and-cytokines
#14
Qiu-Yue Yi, Hong-Bao Li, Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang
Reactive oxygen species (ROS) in the brain are involved in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG), one of the active compounds in green tea, has anti-oxidant, anti-inflammatory and vascular protective properties. This study was designed to determine whether chronic infusion of EGCG into the hypothalamic paraventricular nucleus (PVN) attenuates ROS and sympathetic activity and delays the progression of hypertension by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs) and decreasing nuclear factor-kappa B (NF-κB) activity, as well as restoring the neurotransmitters balance in the PVN of spontaneously hypertensive rats (SHR)...
November 16, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27651256/role-of-quercetin-benefits-in-neurodegeneration
#15
Preetham Elumalai, Sreeja Lakshmi
Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27451102/estrogens-and-coronary-artery-disease-new-clinical-perspectives
#16
M R Meyer, M Barton
In premenopausal women, endogenous estrogens are associated with reduced prevalence of arterial hypertension, coronary artery disease, myocardial infarction, and stroke. Clinical trials conducted in the 1990s such as HERS, WHI, and WISDOM have shown that postmenopausal treatment with horse hormone mixtures (so-called conjugated equine estrogens) and synthetic progestins adversely affects female cardiovascular health. Our understanding of rapid (nongenomic) and chronic (genomic) estrogen signaling has since advanced considerably, including identification of a new G protein-coupled estrogen receptor (GPER), which like the "classical" receptors ERα and ERβ is highly abundant in the cardiovascular system...
2016: Advances in Pharmacology
https://www.readbyqxmd.com/read/27384581/excessive-consumption-of-green-tea-as-a-risk-factor-for-periodontal-disease-among-korean-adults
#17
Kyungdo Han, Eunkyung Hwang, Jun-Beom Park
This study was performed to assess the relationship between the amount of green tea that is consumed and periodontitis. It is based on data obtained from the Korea National Health and Nutrition Examination Survey, conducted between 2008 and 2010. A community periodontal index equal to code 3 was defined as moderate periodontitis, and code 4 was defined as severe periodontitis (n = 16,726). Consumption of green tea less than one cup per day was associated with a decreased prevalence of periodontal disease among Korean adults...
July 2, 2016: Nutrients
https://www.readbyqxmd.com/read/27353642/green-tea-extract-catechin-improves-internal-cardiac-muscle-relaxation-in-rcm-mice
#18
Xiaoqin Wang, Zhengyu Zhang, Gang Wu, Changlong Nan, Wen Shen, Yimin Hua, Xupei Huang
BACKGROUND: Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart's filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed in patients with primary hypertension, diabetes and cardiomyopathies such as hypertrophic cardiomyopathy or restrictive cardiomyopathy. We have generated a restrictive cardiomyopathy (RCM) mouse model with troponin mutations in the heart to mimic the human RCM patients carrying the same mutations...
June 28, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27260124/mitochondrial-dna-5178-c-a-polymorphism-modulates-the-effects-of-coffee-consumption-on-elevated-levels-of-serum-liver-enzymes-in-male-japanese-health-check-up-examinees-an-exploratory-cross-sectional-study
#19
Akatsuki Kokaze, Masao Yoshida, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Hirotaka Ochiai, Takako Shirasawa, Hinako Nanri, Kiyomi Mitsui, Hiromi Hoshimo, Yutaka Takashima
BACKGROUND: Longevity-associated mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia, and abnormal glucose tolerance. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on abnormally elevated levels of serum liver enzymes in male Japanese health check-up examinees. METHODS: A total of 421 male subjects (mean age ± SD, 54...
June 4, 2016: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/26974893/potential-of-food-and-natural-products-to-promote-endothelial-and-vascular-health
#20
Cyril Auger, Amissi Said, Phuong Nga Nguyen, Philippe Chabert, Noureddine Idris-Khodja, Valérie B Schini-Kerth
Endothelial dysfunction is now well established as a pivotal early event in the development of major cardiovascular diseases including hypertension, atherosclerosis, and diabetes. The alteration of the endothelial function is often triggered by an imbalance between the endothelial formation of vasoprotective factors including nitric oxide (NO) and endothelium-dependent hyperpolarization, and an increased level of oxidative stress involving several prooxidant enzymes such as NADPH oxidase and, often also, the appearance of cyclooxygenase-derived vasoconstrictors...
July 2016: Journal of Cardiovascular Pharmacology
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