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nigella sativa hypertension

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https://www.readbyqxmd.com/read/28625957/studies-on-antihyperlipidemic-and-endothelium-modulatory-activities-of-polyherbal-formulation-pol4-and-its-ingredients-in-high-fat-diet-fed-rats
#1
Abdul Malik, Malik Hassan Mehmood, Muhammad Shoaib Akhtar, Ghulam Haider, Anwarul Hassan Gilani
A compound herbal formulation (POL4) is used traditionally in interior parts (Distt. Badin) of Sindh, Pakistan, for the treatment of metabolic disorders like diabetes and hyperlipidemia. This study is aimed to determine the effectiveness of POL4 and its ingredients in hyperlipidemia and associated endothelial dysfunction and hypertension. POL4 is composed of equal proportion of Nigella sativa, Cichorium intybus, Trigonella foenum graecum and Gymnema sylvestre mixed in powdered form. Chronic (6 to 7 weeks) administration of POL4 and its ingredients mixed in diet caused a notable attenuation in total cholesterol, low density lipoprotein cholesterol, triglycerides, atherogenic index, C-reactive protein and glucose, while it has increased high density lipoprotein levels...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28270141/pharmacological-basis-for-the-medicinal-use-of-polyherbal-formulation-and-its-ingredients-in-cardiovascular-disorders-using-rodents
#2
Abdul Malik, Malik Hassan Mehmood, Hajra Channa, Muhammad Shoaib Akhtar, Anwarul-Hassan Gilani
BACKGROUND: A compound herbal formulation (POL4) has been used in the indigenous system of medicine to treat cardiometabolic disorders like diabetes and associated hypertension. POL4 and most of its constituents have not been studied widely for its therapeutic use in hypertension. This study is aimed to determine the efficacy and possible insight into mechanism(s) for the medicinal use of POL4 and its ingredients in hypertension. METHODS: The aqueous methanolic extracts of POL4 (POL4...
March 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28236403/phytochemistry-pharmacology-and-therapeutic-uses-of-black-seed-nigella-sativa
#3
REVIEW
Wesam Kooti, Zahra Hasanzadeh-Noohi, Naim Sharafi-Ahvazi, Majid Asadi-Samani, Damoon Ashtary-Larky
Black seed (Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheumatoid arthritis, asthma, inflammatory diseases, diabetes and digestive diseases. The purpose of this study was to provide a comprehensive review on the scientific reports that have been published about N. sativa. The facts and statistics presented in this review article were gathered from the journals accessible in creditable databases such as Science Direct, Medline, PubMed, Scopus, EBSCO, EMBASE, SID and IranMedex...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28195061/overview-of-the-preclinical-pharmacological-properties-of-nigella-sativa-black-seeds-a-complementary-drug-with-historical-and-clinical-significance
#4
E Z Dajani, T G Shahwan, N E Dajani
Nigella sativa (N. sativa, black seeds; or sometimes known by many other names such as the blessed seed by the Arabs, black cumin in the Holy Bible, black caraway and Kalonji in South Asia) has been traditionally used for many years not only as a food but also as complementary drug. It is the objective of this communication to review the evidence-based pre-clinical pharmacological actions of N. sativa as a basis of its existing and potential new human clinical uses. Primary PubMed literature searches and secondary Medline searches were conducted to define N...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28151458/effect-of-nigella-sativa-supplementation-over-a-one-year-period-on-lipid-levels-blood-pressure-and-heart-rate-in-type-2-diabetic-patients-receiving-oral-hypoglycemic-agents-nonrandomized-clinical-trial
#5
Ahmed Badar, Huda Kaatabi, Abdullah Bamosa, Abdulmohsen Al-Elq, Bodour Abou-Hozaifa, Fatma Lebda, Akram Alkhadra, Sameeh Al-Almaie
BACKGROUND: Diabetic patients with hypertension and dyslipidemia are at a high risk of cardiovascular complications. OBJECTIVES: To determine the effect of Nigella sativa supplementation on the lipid profile, mean arterial pressure, and heart rate in persons with type 2 diabetes on oral hypoglycemic agents (OHA). DESIGN: Single-blind, nonrandomized. SETTING: Diabetes clinic of a university hospital in Saudi Arabia. PATIENTS AND METHODS: Type-2 diabetic patients were recruited by purposive sampling and assigned to treatment or control at the discretion of the investigator with the patient blinded to treatment...
January 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27904549/effects-of-nigella-sativa-supplementation-on-blood-parameters-and-anthropometric-indices-in-adults-a-systematic-review-on-clinical-trials
#6
REVIEW
Alireza Mohtashami, Mohammad Hasan Entezari
BACKGROUND: Nigella sativa (N. sativa) has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension, and obesity. We evaluated the effects of N. sativa supplementation on lipid profiles, glycemic control, blood pressure (BP), and some anthropometric indices in humans. MATERIALS AND METHODS: A search on published studies was done by using databases including PubMed, Google Scholar, Thomas Reuters Web of Science, and Cochrane...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27852303/the-effects-of-nigella-sativa-on-thyroid-function-serum-vascular-endothelial-growth-factor-vegf-1-nesfatin-1-and-anthropometric-features-in-patients-with-hashimoto-s-thyroiditis-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri, Mehran Mesgari Abbasi
BACKGROUND: Hashimoto's thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment of several chronic diseases including hyperlipidemia, hypertension and type 2 diabetes mellitus (T2DM). The aim of the current study was to evaluate the effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis...
November 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27512971/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-investigating-the-effects-of-supplementation-with-nigella-sativa-black-seed-on-blood-pressure
#8
REVIEW
Amirhossein Sahebkar, Davide Soranna, Xiaoqiu Liu, Costas Thomopoulos, Luis E Simental-Mendia, Giuseppe Derosa, Pamela Maffioli, Gianfranco Parati
Several reports suggest a beneficial effect of Nigella sativa on cardiometabolic risk factors, including blood pressure (BP). However, the magnitude of the BP-lowering effect of N. sativa remains controversial. We aimed to calculate this effect size of N. sativa through a systematic review and meta-analysis of randomized controlled trials (RCTs). PubMed, Cochrane Collaboration Library, and SCOPUS were used as data sources of RCTs published before 30 August 2015 (in English only) comparing N. sativa treatment with placebo or standard treatment...
November 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27247918/gastrointestinal-effects-of-nigella-sativa-and-its-main-constituent-thymoquinone-a-review
#9
REVIEW
Farzaneh Shakeri, Zahra Gholamnezhad, Bruno Mégarbane, Ramin Rezaee, Mohammad Hosein Boskabady
Gastrointestinal (GI) diseases affect a large number of people all over the world. Uncontrolled acid secretion and occurrence of gastric ulcers are common disorders of GI tract which pose serious problems to human health. Many synthetic drugs have been used to treat GI disorders but a definite cure has not been discovered so far and the available medications cause several side effects. Nigella sativa (N. sativa) (Ranunculacea) has several therapeutic effects which are attributed to its constituents like nigellicine, nigellidine, thymoquinone, dithymoquinone, thymol and carvacrol...
January 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/26602523/mechanisms-of-the-antihypertensive-effects-of-nigella-sativa-oil-in-l-name-induced-hypertensive-rats
#10
Kamsiah Jaarin, Wai Dic Foong, Min Hui Yeoh, Zaman Yusoff Nik Kamarul, Haji Mohd Saad Qodriyah, Abdullah Azman, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Yusof Kamisah
OBJECTIVES: This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers. METHODS: Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups. One group served as the control (group 1), whereas the other three groups (groups 2-4) were administered L-NAME (25 mg/kg, intraperitoneally)...
November 2015: Clinics
https://www.readbyqxmd.com/read/26366755/black-cumin-nigella-sativa-and-its-active-constituent-thymoquinone-an-overview-on-the-analgesic-and-anti-inflammatory-effects
#11
REVIEW
Bahareh Amin, Hossein Hosseinzadeh
For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the Ranunculaceae family, have been used as a seasoning spice and food additive in the Middle East and Mediterranean areas. Traditionally, the plant is used for asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness, and gastrointestinal disturbances. The literature regarding the biological activities of seeds of this plant is extensive, citing bronchodilative, anti-inflammatory, antinociceptive, antibacterial, hypotensive, hypolipidemic, cytotoxic, antidiabetic, and hepatoprotective effects...
January 2016: Planta Medica
https://www.readbyqxmd.com/read/25859298/thymoquinone-an-emerging-natural-drug-with-a-wide-range-of-medical-applications
#12
REVIEW
Mohannad Khader, Peter M Eckl
Nigella sativa has attracted healers in ancient civilizations and researchers in recent times. Traditionally, it has been used in different forms to treat many diseases including asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness and influenza. Experimentally, it has been demonstrated that N. sativa extracts and the main constituent of their volatile oil, thymoquinone, possess antioxidant, anti-inflammatory and hepatoprotective properties. In this review we aimed at summarizing the most recent investigations related to a few and most important effects of thymoquinone...
December 2014: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/25859297/the-relaxant-effect-of-nigella-sativa-on-smooth-muscles-its-possible-mechanisms-and-clinical-applications
#13
REVIEW
Rana Keyhanmanesh, Zahra Gholamnezhad, Mohammad Hossien Boskabady
Nigella sativa (N. sativa) is a spice plant which has been traditionally used for culinary and medicinal purposes. Different therapeutic properties including the beneficial effects on asthma and dyspnea, digestive and gynecology disorders have been described for the seeds of N. sativa. There is evidence of the relaxant effects of this plant and some of its constituents on different types of smooth muscle including rabbit aorta, rabbit jejunum and trachea. The relaxant effect of N. sativa could be of therapeutic importance such as bronchodilation in asthma, vasodilation in hypertension and therapeutic effect on digestive or urogenital disorders...
December 2014: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/25859296/black-cumin-nigella-sativa-and-its-constituent-thymoquinone-a-review-on-antimicrobial-effects
#14
REVIEW
Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz, Hossein Hosseinzadeh
Nigella sativa seeds have wide therapeutic effects and have been reported to have significant effects against many ailments such as skin diseases, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza and eczema. Thymoquinone (TQ) is one of the most active constituent and has different beneficial properties. Focus on antimicrobial effects, different extracts of N...
December 2014: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/23533459/nigella-sativa-and-its-protective-role-in-oxidative-stress-and-hypertension
#15
Xin-Fang Leong, Mohd Rais Mustafa, Kamsiah Jaarin
Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/23436437/blood-pressure-lowering-effect-of-nigella-sativa-l-seed-oil-in-healthy-volunteers-a-randomized-double-blind-placebo-controlled-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
H Fallah Huseini, M Amini, R Mohtashami, M E Ghamarchehre, Z Sadeqhi, S Kianbakht, A Fallah Huseini
Nigella sativa L. seeds (N. sativa) have been used as a traditional remedy for a wide range of diseases including hypertension. The present study was performed to explore the effects of N. sativa oil on blood pressure (BP) in healthy volunteers. In a double-blind, randomized study, 70 healthy volunteers aged 34 to 63 years with systolic BP from 110 to 140 mmHg and diastolic BP from 60 to 90 mmHg were randomly allocated to receive 2.5 mL N. sativa oil or placebo two times a day for 8 weeks. The systolic and diastolic BPs, body mass index and blood levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, creatinine and blood urea nitrogen were determined at baseline and endpoint...
December 2013: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/22526469/thymoquinone-improves-aging-related-endothelial-dysfunction-in-the-rat-mesenteric-artery
#17
Noureddine Idris-Khodja, Valérie Schini-Kerth
Aging-related endothelial dysfunction is characterized by blunted nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations in arteries, which may be due, at least in part, to increased oxidative stress. Endothelial dysfunction will promote the initiation and development of major cardiovascular diseases such as atherosclerosis and hypertension. Thymoquinone (TQ) is the most active constituent of the volatile oil of Nigella sativa seeds with well-documented antioxidative properties and vasodilator effects...
July 2012: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/21767529/oleic-and-linoleic-acids-are-active-principles-in-nigella-sativa-and-stabilize-an-e-2-p-conformation-of-the-na-k-atpase-fatty-acids-differentially-regulate-cardiac-glycoside-interaction-with-the-pump
#18
Yasser A Mahmmoud, S Brøgger Christensen
Nigella sativa seed oil was found to contain a modulator of Na,K-ATPase. Separation analyses combined with (1)H NMR and GCMS identified the inhibitory fraction as a mixture of oleic and linoleic acids. These two fatty acids are specifically concentrated in several medicinal plant oils, and have particularly been implicated in decreasing high blood pressure. The ouabain binding site on Na,K-ATPase has also been implicated in blood pressure regulation. Thus, we aimed to determine how these two molecules modify pig kidney Na,K-ATPase...
October 2011: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/19500003/effectiveness-safety-and-tolerability-of-powdered-nigella-sativa-kalonji-seed-in-capsules-on-serum-lipid-levels-blood-sugar-blood-pressure-and-body-weight-in-adults-results-of-a-randomized-double-blind-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Waris Qidwai, Hasan Bin Hamza, Riaz Qureshi, Anwar Gilani
OBJECTIVE: The seed extracts from Nigella sativa is used by Unani physicians of traditional medicine (Hakims or Tabibs) and Ayurvedic practitioners (Vaids) in the treatment of several medical disorders including dyslipidemia, obesity, and hypertension. It is, therefore, important to prove or disprove the effectiveness, safety, and tolerability of powdered N. sativa (Kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults. DESIGN: The study design was a randomized, double-blind trial...
June 2009: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/18705755/antihypertensive-effect-of-nigella-sativa-seed-extract-in-patients-with-mild-hypertension
#20
RANDOMIZED CONTROLLED TRIAL
Farshad Roghani Dehkordi, Amir Farhad Kamkhah
Hypertension (HT) is a lifestyle-related disease and dietary modifications are effective for its management and prevention. We conducted a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of treatment with an oral Nigella sativa (NS) seed extract supplement in patients with mild HT. Subjects were randomized into three groups: a placebo and two test groups that received 100 and 200 mg of NS extract twice a day. After 8 weeks, systolic blood pressure (SBP) values in both case groups were found to be significantly reduced when compared with the baseline values for each group...
August 2008: Fundamental & Clinical Pharmacology
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