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Postnatal anxiety

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https://www.readbyqxmd.com/read/29327281/effect-of-early-natal-supplementation-of-paracetamol-on-attenuation-of-exotoxin-endotoxin-induced-pyrexia-and-precipitation-of-autistic-like-features-in-albino-rats
#1
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29325791/the-therapeutic-effects-of-cannabis-and-cannabinoids-an-update-from-the-national-academies-of-sciences-engineering-and-medicine-report
#2
REVIEW
Donald I Abrams
The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committee's 11 prioritized health endpoints- therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances...
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29316996/a-randomised-trial-of-early-palliative-care-for-maternal-stress-in-infants-prenatally-diagnosed-with-single-ventricle-heart-disease
#3
Hayley S Hancock, Ken Pituch, Karen Uzark, Priya Bhat, Carly Fifer, Maria Silveira, Sunkyung Yu, Suzanne Welch, Janet Donohue, Ray Lowery, Ranjit Aiyagari
Children with single-ventricle disease experience high mortality and complex care. In other life-limiting childhood illnesses, paediatric palliative care may mitigate maternal stress. We hypothesised that early palliative care in the single-ventricle population may have the same benefit for mothers. In this pilot randomised trial of early palliative care, mothers of infants with prenatal single-ventricle diagnoses completed surveys measuring depression, anxiety, coping, and quality of life at a prenatal visit and neonatal discharge...
January 10, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29302206/maternal-separation-does-not-produce-a-significant-behavioral-change-in-mice
#4
Shawn Tan, Hin San Ho, Anna Yoonsu Song, Joey Low, Hyunsoo Shawn Je
Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29280981/%C3%AE-n-methylamino-l-alanine-bmaa-toxicity-is-gender-and-exposure-age-dependent-in-rats
#5
Laura Louise Scott, Timothy Grant Downing
Cyanobacterial β-N-methylamino-L-alanine (BMAA) has been suggested as a causative or contributory factor in the development of several neurodegenerative diseases. However, no BMAA animal model has adequately shown clinical or behavioral symptoms that correspond to those seen in either Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS) or Parkinson's Disease (PD). We present here the first data that show that when neonatal rats were exposed to BMAA on postnatal days 3, 4 and 5, but not on gestational day 14 or postnatally on days 7 or 10, several AD and/or PD-related behavioral, locomotor and cognitive deficits developed...
December 27, 2017: Toxins
https://www.readbyqxmd.com/read/29276976/behavioural-phenotypes-in-mice-after-prenatal-and-early-postnatal-exposure-to-intermediate-frequency-magnetic-fields
#6
Kajal Kumari, Hennariikka Koivisto, Capstick Myles, Naarala Jonne, Viluksela Matti, Tanila Heikki, Juutilainen Jukka
Electromagnetic fields are ubiquitous in the environment. Human exposure to intermediate frequency (IF) fields is increasing due to applications like electronic article surveillance systems, wireless power transfer, and induction heating cooking hobs. However, there are limited data on possible health effects of exposure to IF magnetic fields (MF). In the present study, we set out to assess cognitive and behavioural effects of IF MF in mice exposed during prenatal and early postnatal periods. Pregnant female mice were exposed continuously to 7...
December 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/29251222/dietary-polydextrose-and-galactooligosaccharide-increase-exploratory-behavior-improve-recognition-memory-and-alter-neurochemistry-in-the-young-pig
#7
Stephen A Fleming, Supida Monaikul, Alexander J Patsavas, Rosaline V Waworuntu, Brian M Berg, Ryan N Dilger
OBJECTIVES: Previous studies have shown that dietary prebiotics have the potential to improve memory, alter social behavior, and reduce anxiety-like behaviors in rodents. The present research sought to expand upon such results and describe the effects of feeding prebiotics early in life on cognition and neurochemistry using a translational piglet model. METHODS: Pigs were provided customized milk replacer containing 2 g/L each of polydextrose (PDX) and galactooligosaccharide (PDX/GOS) or 0 g/L (Control) from postnatal day (PND) 2-33...
December 18, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29247260/adolescent-cocaine-exposure-induces-prolonged-synaptic-modifications-in-medial-prefrontal-cortex-of-adult-rats
#8
Wei Zhu, Xuhui Ge, Peng Gao, Min Li, Yun Guan, Xiaowei Guan
Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long time, and these modifications may contribute to behavioral deficiencies in adulthood. To address this hypothesis, rats were exposed to cocaine hydrochloride from postnatal day 28 (P28) to P42. When reared to adulthood, rats were subjected to behavioral tests...
December 15, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29246185/early-life-adversity-and-long-term-neurobehavioral-outcomes-epigenome-as-a-bridge
#9
REVIEW
Alexander M Vaiserman, Alexander K Koliada
Accumulating evidence suggests that adversities at critical periods in early life, both pre- and postnatal, can lead to neuroendocrine perturbations, including hypothalamic-pituitary-adrenal axis dysregulation and inflammation persisting up to adulthood. This process, commonly referred to as biological embedding, may cause abnormal cognitive and behavioral functioning, including impaired learning, memory, and depressive- and anxiety-like behaviors, as well as neuropsychiatric outcomes in later life. Currently, the regulation of gene activity by epigenetic mechanisms is suggested to be a key player in mediating the link between adverse early-life events and adult neurobehavioral outcomes...
December 16, 2017: Human Genomics
https://www.readbyqxmd.com/read/29243289/examining-the-content-and-moderators-of-women-s-fears-for-giving-birth-a-meta-synthesis
#10
REVIEW
Kayleigh Sheen, Pauline Slade
AIMS AND OBJECTIVES: This meta-synthesis aimed to identify key elements contributing to FOC derived from women's own reports. BACKGROUND: Fear of childbirth (FOC) encompasses fear or anxiety about giving birth, which can resemble a phobic response. FOC holds implications for women's antenatal and postnatal wellbeing, and decisions made about the birth but a clear definition of the construct does not exist. METHOD: A meta-synthesis was conducted by searching databases (Web of Knowledge, CINAHL, EBSCO, Medline, PsychInfo, and PsychArticles) for qualitative studies describing women's perspectives with respect to fear, anxiety, concerns, phobia or stress about birth...
December 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29241049/prenatal-maternal-mood-patterns-predict-child-temperament-and-adolescent-mental-health
#11
Laura M Glynn, Mariann A Howland, Curt A Sandman, Elysia P Davis, Michael Phelan, Tallie Z Baram, Hal S Stern
BACKGROUND: This study quantifies the dynamics of maternal mood focusing on unpredictability, and to assess if greater unpredictability of prenatal maternal mood predicts child temperament and internalizing symptoms through early adolescence. METHODS: The association between prenatal mood predictability and child internalizing symptoms were assessed in two longitudinal cohorts (N's = 227 and 180). Maternal mood was assessed repeatedly during pregnancy as early as 15 weeks' gestation...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29239949/labor-analgesia-as-a-predictor-for-reduced-postpartum-depression-scores-a-retrospective-observational-study
#12
Grace Lim, Lia M Farrell, Francesca L Facco, Michael S Gold, Ajay D Wasan
BACKGROUND: Using labor, epidural analgesia has been linked to a reduced risk of postpartum depression, but the role of labor pain relief in this association remains unclear. The goal of this study was to test the hypothesis that effective epidural analgesia during labor is associated with reduced postpartum depression symptomatology. METHODS: A single, institutional, retrospective, observational cohort design was chosen. The primary outcome was Edinburgh postnatal depression scale (EPDS) score, measured at the 6-week postpartum visit...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29237385/systemic-administrations-of-antipsychotic-asenapine-pre-or-postnatal-does-not-induce-anxiety-like-behaviors-in-mice
#13
Maria Silvia Oliveira, Thais Souza Barbosa de Souza, Daniela Miranda Farias, Rozimeri Fatima Coletti, Jorge Aparecido de Barros, Carolina Gomes Carrilho, Susana Elisa Moreno, Eric Murillo Murillo Rodriguez, Sergio Machado, Andre Barciela Veras
Asenapine is an atypical antipsychotic approved by US Food and Drug Administration in 2009 and by European Medicines Agency in 2010 for schizophrenia and bipolar disorder treatment. Currently, many studies have been developed in an attempt to clarify and minimize the risks related to the use of psychotropic during pre/postnatal period on patients with a history of mental disorders. To this finality, the purpose of the following work was to test on animal models the impact of being exposed to this medication during perinatal period upon anxiety and exploration/emotionality of female mice's descendants submitting them, in adulthood, to the Open Field and Elevated Plus Maze test...
December 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29234279/long-term-effects-of-intermittent-adolescent-alcohol-exposure-in-male-and-female-rats
#14
Eva M Marco, Sara Peñasco, María-Donina Hernández, Anabel Gil, Erika Borcel, Marta Moya, Elena Giné, José Antonio López-Moreno, Consuelo Guerri, Meritxell López-Gallardo, Fernando Rodríguez de Fonseca
Alcohol is a serious public health concern that has a differential impact on individuals depending upon age and sex. Patterns of alcohol consumption have recently changed: heavy episodic drinking-known as binge-drinking-has become most popular among the youth. Herein, we aimed to investigate the consequences of intermittent adolescent alcohol consumption in male and female animals. Thus, Wistar rats were given free access to ethanol (20% in drinking water) or tap water for 2-h sessions during 3 days, and for an additional 4-h session on the 4th day; every week during adolescence, from postnatal day (pnd) 28-52...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29230623/depression-and-anxiety-lack-of-associations-with-an-inadequate-diet-in-a-sample-of-pregnant-women-with-a-history-of-bariatric-surgery-a-multicenter-prospective-controlled-cohort-study
#15
Goele Jans, Christophe Matthys, Annick Bogaerts, Lieveke Ameye, Frank Delaere, Kristien Roelens, Anne Loccufier, Hilde Logghe, Ben De Becker, Johan Verhaeghe, Roland Devlieger
BACKGROUND: Anxiety and depression levels are higher in obese compared to those in normal weight pregnant women. The aims of this study are to examine anxiety and depression in pregnancy following bariatric surgery and to compare with obese pregnant controls considering the dietary intake of polyunsaturated fatty acids (PUFA), folate, and vitamin B12. METHODS: Anxiety (State-Trait Anxiety Inventory) and depression (Edinburgh Postnatal Depression Scale) were examined in the first (T1) and third (T3) pregnancy trimester in 54 women with bariatric surgery and 25 obese...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29229409/postpartum-depression-screening-and-pelvic-floor-symptoms-among-women-referred-to-a-specialty-postpartum-perineal-clinic
#16
Carolyn W Swenson, Julia A DePorre, Jessica K Haefner, Mitchell B Berger, Dee E Fenner
BACKGROUND: Postpartum depression (PPD) and pelvic floor disorders are both common conditions that affect women; however, the association between the two has yet to be determined. OBJECTIVE: The aims of our study are to: 1) determine the prevalence of a positive postpartum depression screen (PPD) in a specialty postpartum perineal clinic, and 2) identify risk factors for postpartum depression in this population. STUDY DESIGN: A retrospective chart review was performed of 294 women referred to a specialty postpartum perineal clinic at the University of Michigan between March 30, 2012 and May 3, 2016...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229361/a-literature-review-on-maternal-fetal-and-reproductive-disorders-of-toxoplasma-gondii-infection
#17
REVIEW
Shirzad Fallahi, Ali Rostami, Malihe Nourollahpour Shiadeh, Hamed Behniafar, Shahrokh Paktinat
BACKGROUND: Toxoplasma gondii infection is one of the most prevalent infectious disease with worldwide distribution. Congenital toxoplasmosis is annually responsible for 1.20 million disability-adjusted life years around the world, but often it is overlooked many countries. METHODS: We performed an updated review to summarize the current researches on fetal, neonatal and maternal consequences of T. gondii infection and also adverse effects of toxoplasmosis on women reproductive organs...
December 8, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29229141/neurodevelopment-impact-of-co2-pneumoperitoneum-in-neonates-experimental-study-in-a-rat-model
#18
Alice Miranda, Susana Roque, José M Pêgo, Jorge Correia-Pinto
BACKGROUND: Laparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes. MATERIALS AND METHODS: Rats were subjected to a systematic assessment of neurodevelopmental milestones between postnatal day 1 (PND 1) and PND 21...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29223527/low-doses-of-prenatal-ethanol-exposure-and-maternal-separation-alter-hpa-axis-function-and-ethanol-consumption-in-adult-male-rats
#19
F Biggio, G Talani, V Locci, M G Pisu, G Boero, B Ciarlo, D R Grayson, M Serra
Adverse maternal behaviors during pregnancy and unfavorable postnatal experiences during development are associated with an increased risk of developing psychiatric disorders, as well as, a vulnerability to alcohol addiction in adulthood. Here, we examined the effects of combined ethanol exposure during late pregnancy and postnatal maternal separation (MS) on HPA responsiveness, anxiety behavior and preference for alcohol consumption in adult male rats. Animals exposed to both conditions revealed a decrease in blood levels of allopregnanolone accompanied by increased anxiety behavior...
December 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29221334/minimally-invasive-multi-disciplinary-approach-for-surgical-management-of-a-mediastinal-congenital-bronchogenic-cyst-in-a-6-month-old-infant
#20
Xiao-Hua Li, Tao Zhang, Sheng Wang, Biao-Chuan He, Xue-Ning Yang, Wen-Zhao Zhong, Ji-Mei Chen
We present a case of prenatal diagnosis of a mediastinal cyst by ultrasound, confirmed during infancy through computed tomography (CT) and magnetic resonance imaging (MRI). A 6-month-old male infant was admitted to the hospital. A mid-mediastinal cyst was detected through a province-wide fetal ultrasonography screening program. During the infancy stage, the CT scan and the MRI confirmed the finding of a mediastinal cyst. Based on the findings on prenatal ultrasonography and postnatal imaging studies (CT, MRI), a benign mediastinal cyst was suspected...
September 2017: Journal of Thoracic Disease
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