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Postnatal anxiety

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https://www.readbyqxmd.com/read/29774754/effect-of-di-2-ethylhexyl-phthalate-on-the-neuroendocrine-regulation-of-reproduction-in-adult-male-rats-and-its-relationship-to-anxiogenic-behavior-participation-of-gabaergic-system
#1
S Carbone, O J Ponzo, N Gobetto, Y A Samaniego, R Reynoso, J A Moguilevsky, R A Cutrera
The endocrine disruptor di-(2-ethylhexyl) phthalate (DEHP) is used in a variety of consumer products made with polyvinyl chloride and also in the manufacture of medical devices. DEHP disrupts reproductive tract development in an antiandrogenic manner and also may induce neurobehavioral changes. The aim of this study was to investigate the effects of chronic postnatal exposure to DEHP (30 mg/kg body weight/day, orally from birth to day 60) on the neuroendocrine regulation of the gonadal axis and its impact on the anxiety-like behavior in adult male rats, as well as the probable participation of the GABAergic system in these effects...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29772261/maternal-immune-activation-with-staphylococcal-enterotoxin-a-produces-unique-behavioral-changes-in-c57bl-6-mouse-offspring
#2
Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W Kusnecov
Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like receptors. However, fewer studies have examined the role of direct activation of maternal T-cells during pregnancy using microbial agents...
May 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29772083/effects-of-prenatal-stress-on-anxiety-and-depressive-like-behaviors-are-sex-specific-in-prepubertal-rats
#3
Ann Mary Iturra-Mena, Marcia Arriagada-Solimano, Ariane Luttecke-Anders, Alexies Dagnino-Subiabre
The fetal brain is highly susceptible to stress in late pregnancy, with lifelong effects of stress on physiology and behavior. The aim of this study was to determine the physiological and behavioral effects of prenatal stress during the prepubertal period of female and male rats. We subjected pregnant Sprague-Dawley rats to a restraint stress protocol from gestational day 14 until 21, a critical period for fetal brain susceptibility to stress effects. Male and female offspring were subsequently assessed at postnatal day 24 for anxiety- and depressive-like behaviors, and spontaneous social interaction...
May 17, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29763437/postnatal-colonization-with-human-infant-type-bifidobacterium-species-alters-behavior-of-adult-gnotobiotic-mice
#4
Berkley Luk, Surabi Veeraragavan, Melinda Engevik, Miriam Balderas, Angela Major, Jessica Runge, Ruth Ann Luna, James Versalovic
Accumulating studies have defined a role for the intestinal microbiota in modulation of host behavior. Research using gnotobiotic mice emphasizes that early microbial colonization with a complex microbiota (conventionalization) can rescue some of the behavioral abnormalities observed in mice that grow to adulthood completely devoid of bacteria (germ-free mice). However, the human infant and adult microbiomes vary greatly, and effects of the neonatal microbiome on neurodevelopment are currently not well understood...
2018: PloS One
https://www.readbyqxmd.com/read/29754019/threatened-miscarriage-and-depressive-and-anxiety-symptoms-among-women-and-partners-in-early-pregnancy
#5
Cindy Shiqi Zhu, Thiam Chye Tan, Helen Yu Chen, Rahul Malhotra, John Carson Allen, Truls Østbye
BACKGROUND: Antenatal depression has been associated with poor maternal and fetal outcomes, and threatened miscarriage is often seen clinically to impact adversely on maternal wellbeing, notwithstanding the limited research evidence. Our study aims to examine the link between threatened miscarriage and antenatal depression and anxiety in an Asian obstetric population. METHODS: We recruited 121 women and 68 partners facing threatened miscarriage, and 241 women and 180 partners experiencing uncomplicated pregnancies from a tertiary maternity hospital in Singapore...
April 12, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29753050/sex-specific-differences-in-corticosterone-secretion-behavioral-phenotypes-and-expression-of-trkb-t1-and-trkb-fl-receptor-isoforms-impact-of-systemic-trkb-inhibition-and-combinatory-stress-exposure-in-adolescence
#6
Idu Azogu, Jacky Liang, Helene Plamondon
Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal day (PND) 26 to 35), we examined sex-specific impact of adolescent stress and inhibition of tyrosine-related kinase B (TrkB) receptor (ANA-12; 0.5 mg/kg, i.p.) on 1) adolescent blood corticosterone levels, 2) adult locomotion and anxiety behavior, and 3) region-specific differences in endogenous TrkB full-length (TrkB...
May 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29752970/repeated-cycles-of-binge-like-ethanol-exposure-induce-immediate-and-delayed-neurobehavioral-changes-and-hippocampal-dysfunction-in-adolescent-female-rats
#7
Luanna M P Fernandes, Sabrina C Cartágenes, Mayara A Barros, Taiana C V S Carvalheiro, Nair Correia de Freitas Castro, Marissa G Schamne, Rafael R Lima, Rui D Prediger, Marta C Monteiro, A F Enéas, Rodrigo A Cunha, Cristiane S F Maia
Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. We now submitted female Wistar rats to repeated cycles of binge-like ethanol treatment by intragastrically administering ethanol (3.0 g/kg/day, 20% w/v ethanol; 3 days on/4 days off) starting at postnatal day 35 (PND35). To investigate the short-term effects of BEI during adolescence, rats underwent 1 or 4 cycles of BEI, being evaluated at PND37 and PND58, respectively: both groups displayed anxiety-like behavior in the open field and elevated plus-maze tests, as well as short-term memory deficits in the object recognition task; this was associated with transient decreases of BDNF levels and increases of GFAP levels in the hippocampus...
May 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29749116/neonatal-pain-and-stress-disrupts-later-life-pavlovian-fear-conditioning-and-sensory-function-in-rats-evidence-for-a-two-hit-model
#8
Seth M Davis, Makaela Rice, Jacob Rudlong, Victoria Eaton, Tamara King, Michael A Burman
Early life trauma has been linked to increased risks for anxiety, depression, and chronic pain. We used rodent models of acute and inflammatory neonatal pain to explore effects on fear conditioning and somatosensory function. Hindpaw needle pricks or handling on postnatal days (PNDs) 1-7 caused lasting impacts on affective and somatosensory function when assessed at later ages, PNDs 24 (postweaning), 45 (adolescence), or 66 (adulthood). First, auditory, but not contextual, freezing was mildly disrupted regardless of age...
May 10, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29730512/the-pregnancy-related-anxiety-scale-a-validity-examination-using-rasch-analysis
#9
Robyn J Brunton, Rachel Dryer, Chris Krägeloh, Anthony Saliba, Jane Kohlhoff, Oleg Medvedev
BACKGROUND: Pregnancy-related anxiety is increasingly recognised as a common condition that is associated with many deleterious outcomes for both the mother and infant (e.g., preterm birth, postnatal depression). Limitations in the psychometric properties and/or breadth of existing scales for pregnancy-related anxiety highlight the need for a psychometrically sound measure to facilitate effective screening and possible early interventions. The recently developed Pregnancy-related Anxiety Scale (PrAS) was evaluated using Rasch analysis to explore how the scale's psychometric properties could be fine-tuned...
April 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29730511/do-mothers-who-are-anxious-during-pregnancy-have-inattentive-children
#10
Blanca Bolea-Alamañac, Simon Jc Davies, Jonathan Evans, Carol Joinson, Rebecca Pearson, Petros Skapinakis, Alan Emond
BACKGROUND: Maternal somatic anxiety during pregnancy may affect neural foetal development via corticoid pathways. Using a large epidemiological cohort, this study explores the relationship between maternal somatic anxiety in pregnancy and child scores on the Test of Everyday Attention in Children (TEA-Ch). METHODS: Linear regression was used to analyse the association of maternal somatic anxiety during pregnancy and performance of children on three subtests of the TEA-Ch at age 8...
April 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29729302/neonatal-immune-activation-by-lipopolysaccharide-causes-inadequate-emotional-responses-to-novel-situations-but-no-changes-in-anxiety-or-cognitive-behavior-in-wistar-rats
#11
Iveta Vojtechova, Tomas Petrasek, Kristyna Maleninska, Hana Brozka, Hana Tejkalova, Jiri Horacek, Ales Stuchlik, Karel Vales
Infection during the prenatal or neonatal stages of life is considered one of the major risk factors for the development of mental diseases such as schizophrenia or autism. However, the impacts of such an immune challenge on adult behavior are still not clear. In our study, we used a model of early postnatal immune activation by the application of bacterial endotoxin lipopolysaccharide (LPS) to rat pups at a dose of 2 mg/kg from postnatal day (PD) 5 to PD 9. In adulthood, the rats were tested in a battery of tasks probing various aspects of behavior: spontaneous activity (open field test), social behavior (social interactions and female bedding exploration), anxiety (elevated plus maze), cognition (active place avoidance in Carousel) and emotional response (ultrasonic vocalization recording)...
May 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29723593/sex-dependent-impact-of-different-degrees-of-maternal-separation-experience-on-oft-behavioral-performances-after-adult-chronic-unpredictable-mild-stress-exposure-in-rats
#12
Yanyan Wei, Gaohua Wang, Huiling Wang, Jing He, Nan Zhang, Zuotian Wu, Ling Xiao, Can Yang
Early-life social-environmental factors are important for normal development, and different degrees of early-life stress experience have different impacts on adult behaviors and stress responsiveness. The aim of present study was to investigate the long-term effects of different degrees of maternal separation (MS) on male and female rats and subsequent responsiveness to chronic unpredictable mild stress (CUMS) exposure in adults. Sprague-Dawley (SD) newborn pups were exposed to either 15 min/day of MS (MS15), 360 min/day of MS (MS360) or no separation (NS) during postnatal day (PND)4-PND10...
April 30, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29715609/the-impact-of-pre-and-perinatal-factors-on-psychopathology-in-adulthood
#13
Cecilia A Essau, Satoko Sasagawa, Peter M Lewinsohn, Paul Rohde
BACKGROUND: There is considerable evidence that pre- and post-natal factors are associated with a wide range of psychopathology in offspring during childhood and adolescence. OBJECTIVE: The main aims of the present study were to examine the associations between pre- and perinatal factors and psychopathology in offspring during adulthood, and to explore whether family factors (i.e., family cohesion, mother's social support, and father's social support) mediate these relationships...
April 21, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29696603/reappraising-preclinical-models-of-separation-anxiety-disorder-panic-disorder-and-co-2-sensitivity-implications-for-methodology-and-translation-into-new-treatments
#14
Marco Battaglia, Waqas Ullah Khan
Separation anxiety applies to multiple forms of distress responses seen in mammals during postnatal development, including separation from a caregiver. Childhood separation anxiety disorder is an important risk factor for developing panic disorder in early adulthood, and both conditions display an increased sensitivity to elevated CO2 concentrations inhaled from the air. By interfacing epidemiological, genetic, and physiological knowledge with preclinical animal research models, it is possible to decipher the mechanisms that are central to separation anxiety and panic disorders while also suggesting possible therapies...
April 26, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29695386/the-relationship-between-intimate-partner-violence-reported-at-the-first-antenatal-booking-visit-and-obstetric-and-perinatal-outcomes-in-an-ethnically-diverse-group-of-australian-pregnant-women-a-population-based-study-over-10-years
#15
Hannah Grace Dahlen, Ana Maria Munoz, Virginia Schmied, Charlene Thornton
OBJECTIVES: Intimate partner violence (IPV) is a global health issue affecting mainly women and is known to escalate during pregnancy and impact negatively on obstetric and perinatal outcomes. The aim of this study is to determine the incidence of IPV in a pregnant multicultural population and to determine the relationship between IPV reported at booking interview and maternal and perinatal outcomes. DESIGN: This is a retrospective population-based data study. We analysed routinely collected data (2006-2016) from the ObstetriX system on a cohort of pregnant women...
April 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29694970/repetitive-negative-thinking-and-its-role-in-perinatal-mental-health
#16
Michelle L Moulds, Melissa J Black, Jill M Newby, Colette R Hirsch
BACKGROUND: There is evidence that anxiety is common, perhaps even more prevalent than depression, in the post-partum period. In this review we propose adopting a transdiagnostic approach to perinatal mental health: to delineate psychopathology and identify potential underlying cognitive mechanisms such as repetitive negative thinking (RNT). SAMPLING AND METHODS: We provide an overview of key studies of RNT in perinatal mental health and suggest directions for future work...
April 25, 2018: Psychopathology
https://www.readbyqxmd.com/read/29694295/psychological-functioning-of-women-taking-illicit-drugs-during-pregnancy-and-the-growth-and-development-of-their-offspring-in-early-childhood
#17
Dana Serino, Bradley S Peterson, Tove S Rosen
OBJECTIVE: Assess psychosocial history and psychological functioning in women who use drugs during pregnancy and determine how drug exposure affects child development. METHODS: Pregnant marijuana (n = 38), cocaine (n = 35), methadone-maintained (n = 24), and control (n = 49) group women were enrolled and followed every 6 months through 18-24 months postnatally. RESULTS: There was a significantly higher incidence of mental illness in mothers in the drug groups...
April 25, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29691979/the-bdnf-val68met-polymorphism-modulates-how-developmental-ethanol-exposure-impacts-the-hippocampus
#18
Clark W Bird, Brian C Baculis, Jacob J Mayfield, Glenna J Chavez, Tiahna Ontiveros, Dana J Paine, Aaron J Marks, Alicia L Gonzales, Dorit Ron, C Fernando Valenzuela
Prenatal exposure to alcohol causes a wide range of deficits known as Fetal Alcohol Spectrum Disorders (FASDs). Many factors determine vulnerability to developmental alcohol exposure including timing and pattern of exposure, nutrition, and genetics. Here, we characterized how a prevalent single nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (val66met) modulates FASDs severity. This polymorphism disrupts BDNF's intracellular trafficking and activity dependent secretion, and has been linked to increased incidence of neuropsychiatric disorders such as depression and anxiety...
April 24, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29684795/screening-for-postpartum-anxiety-a-quality-improvement-project-to-promote-the-screening-of-women-suffering-in-silence
#19
Sarah Toler, Susan Stapleton, Kim Kertsburg, Tiffany J Callahan, Marie Hastings-Tolsma
BACKGROUND: Postpartum anxiety is a mental health problem that has largely been ignored by maternity care providers despite an estimated incidence as high as 28.9%. Though postpartum anxiety may or may not be accompanied by depression, and while screening for postpartum depression has become more common place, postpartum anxiety is often not assessed or addressed. PURPOSE: The purpose of this pilot quality improvement project was to implement a screening, treatment and referral program for postpartum anxiety in the birth centre environment...
April 3, 2018: Midwifery
https://www.readbyqxmd.com/read/29678562/effects-of-postnatal-handling-on-adult-behavior-and-brain-mrna-expression-of-serotonin-receptor-brain-derived-neurotrophic-factor-and-gaba-a-receptor-subunit
#20
Haiyan Li, Chihiro Ishikawa, Takashi Shiga
Development of brain and behavior is influenced by the interaction of genetic and environmental factors. Postnatal handling, a manipulation that briefly separates mouse offspring from their mother during the postnatal period, has been reported to yield beneficial effects on the behavior of adult offspring. However, brain mechanisms underlying the effects on the behavior have not been well understood. Here we first examined effects of postnatal handling on the behavior of adult male BALB/c mice. Offspring were separated for 15 min every day between postnatal day 1 (P1) and P14 and then various behaviors were tested in the adulthood...
April 17, 2018: International Journal of Developmental Neuroscience
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