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https://www.readbyqxmd.com/read/29137551/environmental-manipulations-as-an-effective-alternative-treatment-to-reduce-endometriosis-progression
#1
Annelyn Torres-Reverón, Leslie L Rivera, Idhaliz Flores, Caroline B Appleyard
Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplantation rat model. Female rats were exposed to EE (endo-EE: toys and nesting materials, 4 rats per cage, larger area enclosure) or no enrichment (endo-NE: 2 rats per cage) starting on postnatal day 21. After 8 weeks, sham surgery or surgical endometriosis was induced by suturing uterine horn tissue next to the intestinal mesentery, then allowed to progress for 60 days during which EE or NE continued...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29127070/an-early-experience-of-mild-adversity-involving-temporary-denial-of-maternal-contact-affects-the-serotonergic-system-of-adult-male-rats-and-leads-to-a-depressive-like-phenotype-and-inability-to-adapt-to-a-chronic-social-stress
#2
Anastasia Diamantopoulou, Theodora Kalpachidou, Georgios Aspiotis, Ioannis Gampierakis, Fotini Stylianopoulou, Antonios Stamatakis
Adverse early life experiences can affect adaptability to chronic stressors and lead to depressive-like behaviors in animal models. We employed an early experience model in which rat pups during postnatal days 10-13 are exposed to a T-maze in which they learn the location of their mother motivated by the rewarding stimulus of maternal contact; one group of rats receives the expected reward, by being allowed contact with the mother upon finding her, while the other group is temporarily denied this contact (Denied Expected Reward, DER), thus experiencing mild adversity...
November 7, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29125056/monosodium-glutamate-and-treadmill-exercise-anxiety-like-behavior-and-spreading-depression-features-in-young-adult-rats
#3
Suênia Marcele Vitor-de-Lima, Larissa de Brito Medeiros, Regina de Deus Lira Benevides, Catarina Nicácio Dos Santos, Nahara Oliveira Lima da Silva, Rubem Carlos Araújo Guedes
OBJECTIVES: The route of administration is an important factor in determining the action of some drugs. We previously demonstrated that subcutaneous monosodium glutamate (MSG) accelerated cortical spreading depression (CSD) in the rat and that treadmill exercise attenuated this effect. This study evaluated whether other routes of administration exert the same action by testing orogastric (gavage) and topical cortical MSG administration in treadmill-exercised and sedentary rats. Additionally, in the orogastric treatment we tested anxiety-like behavior...
November 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29116368/n-acetyl-cysteine-reverses-bio-behavioural-changes-induced-by-prenatal-inflammation-adolescent-methamphetamine-exposure-and-combined-challenges
#4
Twanette Swanepoel, Marisa Möller, Brian Herbert Harvey
RATIONALE: Schizophrenia is associated with prenatal inflammation and/or postnatal stressors such as drug abuse, resulting in immune-redox dysfunction. Antioxidants may offer therapeutic benefits. OBJECTIVES: The objective of this study is to investigate N-acetyl cysteine (NAC) as a therapeutic antioxidant to reverse schizophrenia-like bio-behavioural changes in rats exposed to maternal immune activation (MIA), adolescent methamphetamine (MA) or a combination thereof...
November 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29107975/trajectories-of-maternal-ante-and-postpartum-depressive-symptoms-and-their-association-with-child-and-mother-related-characteristics-in-a-west-african-birth-cohort-study
#5
Dana Barthel, Levente Kriston, Daniel Fordjour, Yasmin Mohammed, Esther Doris Kra-Yao, Carine Esther Bony Kotchi, Ekissi Jean Koffi Armel, Kirsten Alexandra Eberhardt, Torsten Feldt, Rebecca Hinz, Koffi Mathurin, Stefanie Schoppen, Carola Bindt, Stephan Ehrhardt
BACKGROUND: The vast majority of research on mental health has been undertaken in high income countries. This study aimed at investigating the long-term course of maternal depressive symptoms and its association with various mother- and child-related characteristics in two West African lower middle income countries with focus on the relationship with long-term anxiety symptoms. METHODS: In the Child Development Study, a prospective birth cohort study in Côte d'Ivoire and Ghana, the 9-item Patient Health Questionnaire (PHQ-9) was answered by N = 776 women 3 months antepartum, and 3, 12, and 24 months postpartum between April 2010 and March 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29103314/using-the-epds-to-identify-anxiety-in-mothers-of-infants-on-the-neonatal-intensive-care-unit
#6
Sara M Stasik-O'Brien, Jennifer E McCabe-Beane, Lisa S Segre
Despite the prevalence of postpartum depression and anxiety, current screening recommendations are limited to depression symptoms. Screening using the Edinburgh Postnatal Depression Scale-Anxiety subscale (EPDS-A) may enhance ability to detect distress in postpartum women. We aimed to replicate the EPDS-A in 200 mothers with infants hospitalized in the neonatal intensive care unit (NICU) and examine its incremental utility in identifying emotional distress. Presence of the EPDS-A was identified using exploratory factor analysis...
November 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29098186/chronic-adolescent-%C3%AE-9-tetrahydrocannabinol-treatment-of-male-mice-leads-to-long-term-cognitive-and-behavioral-dysfunction-which-are-prevented-by-concurrent-cannabidiol-treatment
#7
Michelle Murphy, Sierra Mills, Joanna Winstone, Emma Leishman, Jim Wager-Miller, Heather Bradshaw, Ken Mackie
Introduction: The high prevalence of adolescent cannabis use, the association between this use and later psychiatric disease, and increased access to high-potency cannabis highlight the need for a better understanding of the long-term effects of adolescent cannabis use on cognitive and behavioral outcomes. Furthermore, increasing Δ(9)-tetrahydrocannabinol (THC) in high-potency cannabis is accompanied by a decrease in cannabidiol (CBD), thus an understanding of the interactions between CBD and THC in the neurodevelopmental effects of THC is also important...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29096641/acute-in-utero-exposure-to-lipopolysaccharide-induces-inflammation-in-the-pre-and-postnatal-brain-and-alters-the-glial-cytoarchitecture-in-the-developing-amygdala
#8
Elaine O'Loughlin, Janelle M P Pakan, Deniz Yilmazer-Hanke, Kieran W McDermott
BACKGROUND: Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of emotions, and amygdalar maldevelopment due to infection-induced MIA may lead to amygdala-related disorders. MIA priming of glial cells during development has been linked to abnormalities seen in later life; however, little is known about its effects on amygdalar biochemical and cytoarchitecture integrity...
November 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29096280/paternal-postnatal-depression-in-ireland-prevalence-and-associated-factors
#9
Lloyd Frank Philpott, Paul Corcoran
BACKGROUND: it is well established that fatherhood has a long term positive and protective effect on men's health. However, there is also evidence that the transition to fatherhood can be complex and demanding and can lead to distress, anxiety and increased risk of depression. OBJECTIVE: this study aimed to investigate the prevalence of paternal postnatal depression, and to examine associations with a range of demographic and clinical factors. METHODS: a cross-sectional study design was used to collect primary data from 100 fathers, whose partner gave birth to an infant in the previous 12 months...
October 20, 2017: Midwifery
https://www.readbyqxmd.com/read/29092785/effects-of-cb1-receptor-antagonism-and-stress-exposures-in-adolescence-on-socioemotional-behaviours-neuroendocrine-stress-responses-and-expression-of-relevant-proteins-in-the-hippocampus-and-prefrontal-cortex-in-rats
#10
Jonathan J Simone, Jennet L Baumbach, Cheryl M McCormick
Little is known about the consequences of altered endocannabinoid signalling in adolescence. We hypothesized that CB1 receptor antagonism (AM251, 1 mg/kg) and stress exposures (1 h confinement stress) in adolescence (daily, postnatal days 30-44) would interact to increase neuroendocrine stress responses and anxiety when investigated a minimum of 24 h after drug and stress treatments; these treatment effects were independent of each other. Changes in homecage behaviour and in weight gain confirmed that both males and females were sensitive to the treatments...
October 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29077529/postnatal-melatonin-treatment-protects-against-affective-disorders-induced-by-early-life-immune-stimulation-by-reducing-the-microglia-cell-activation-and-oxidative-stress
#11
I Berkiks, H Benmhammed, A Mesfioui, A Elhasnaoui, S Mouden, T Touil, Y Bahbiti, R Nakache, A Ouichou, A El Hessni
Systemic inflammation induced by neonatal infection may result as long-term hyperactivation of microglial cells followed by an overproduction of pro-inflammatory cytokines, such as tumor necrosis factor (TNF-α), nitric oxide (NO), and lipid peroxidation. Those inflammation mediators can trigger behavioral disruption and/or cognitive disorders. The present work aims to evaluate the effect of melatonin (a cytokine release modulator and antioxidant agent) in the reduction of the prefrontal microglia activation and depressive-like behaviors induced by LPS injection in adult rats...
October 27, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29075574/perinatal-western-type-diet-and-associated-gestational-weight-gain-alter-postpartum-maternal-mood
#12
Jessica L Bolton, Melanie G Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y Yang, Olga Ilkayeva, Thomas M O'Connell, Shelley W Wroth, Cristina L Sánchez, Geeta Swamy, Christopher Newgard, Cynthia Kuhn, Staci D Bilbo, Leigh Ann Simmons
INTRODUCTION: The role of perinatal diet in postpartum maternal mood disorders, including depression and anxiety, remains unclear. We investigated whether perinatal consumption of a Western-type diet (high in fat and branched-chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A). METHODS: Mouse dams were fed one of four diets (high-fat/high BCAA, low-fat/high BCAA, high-fat, and low-fat) prior to mating and throughout gestation and lactation...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29072385/-medical-clowns-the-triple-value-clown-parent-premature-neonate
#13
REVIEW
Hagit Friedman, Shay Barak, Yelena Chulsky, Shoshi Ofir, Amir Kushnir
The infant's brain develops rapidly during the prenatal and early postnatal period. Temporary new neural circuits appear, such as the sub-cortical plate (SCP). SCP links the thalamus and cortex in a time window of sensory circuits' intensive development, creating the basis for the infant's bonding interactions. SCP activity in premature neonates is vulnerable and hypoxic injury may have a long lasting influence on brain development. Preterm birth is an emotional trauma for the parents and may lead to depression, anxiety and stress...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29067549/relationship-of-bipolar-disorder-with-psychiatric-comorbidity-in-the-postpartum-period-a-scoping-review
#14
REVIEW
Verinder Sharma
Childbirth can trigger a variety of psychiatric disorders; however, no disorder is as profoundly affected by childbirth as bipolar disorder. Rates of psychiatric comorbidity especially anxiety disorders, obsessive compulsive disorder, and substance use disorders are quite high in individuals with bipolar disorder. The purpose of this scoping review is to ascertain the effect of childbirth on the relationship between the onset of bipolar disorder and comorbid psychiatric disorders. On June 27, 2017, a search of the Medline, PsycINFO, CINHAL, EMBASE, SCOPUS, COCHRANE, and ISI-Web of Science (WOS) databases was performed using the terms mental disorders, mental disease, major depressive disorder, major depression, depression, panic disorder, bipolar disorder, comorbidity, anxiety disorders, obsessive compulsive disorder, post-traumatic stress disorder, schizophrenia, eating disorders, reactive attachment disorder, childbirth, parturition, puerperium, postpartum, postpartum period and postnatal period...
October 24, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29065375/cryptorchidism-and-increased-risk-of-neurodevelopmental-disorders
#15
Jianping Chen, Henrik Toft Sørensen, Maohua Miao, Hong Liang, Vera Ehrenstein, Ziliang Wang, Wei Yuan, Jiong Li
Male congenital malformations as cryptorchidism may contribute to the development of neurodevelopmental disorders directly or via shared familial genetic and/or environmental factors, but the evidence is sparse. Using population-based health registries, we conducted a cohort study of all liveborn singleton boys in Denmark during 1979-2008. Boys with a diagnosis of cryptorchidism were categorized into the exposed cohort and the other boys into the unexposed comparison cohort. The outcomes were diagnoses of any neurodevelopmental disorders and their subtypes...
October 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29064265/pregnancy-complications-and-wheezing-and-asthma-in-childhood
#16
Franca Rusconi, Luigi Gagliardi
This review focuses on recent advances in the field of several frequent maternal complications in pregnancy and asthma and wheezing in childhood, for which large birth cohort studies have recently provided clues. Within the framework of epidemiologic studies, we discuss potential mechanisms, mediators and confounders involved in associations, in an attempt to discern causal pathways. Preeclampsia, a pregnancy-specific multiorgan disease that affects 2-4% of women in developed countries, is characterized by placental dysfunction and is associated with preterm delivery, fetal growth restriction and vascular and lung effects in the fetus...
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29057552/children-prenatally-exposed-to-maternal-anxiety-devote-more-attentional-resources-to-neutral-pictures
#17
Marion I van den Heuvel, Jens Henrichs, Franc C L Donkers, Bea R H Van den Bergh
Maternal anxiety during pregnancy can negatively affect fetal neurodevelopment, predisposing the offspring to a higher risk of behavioral and emotional problems later in life. The current study investigates the association between maternal anxiety during pregnancy and child affective picture processing using event-related brain potentials (ERPs). Mothers reported anxiety during the second trimester using the anxiety subscale of the Symptom Checklist (SCL-90). At age 4 years, child affective picture processing (N = 86) was measured by recording ERPs during viewing of neutral, pleasant, and unpleasant pictures selected from the International Affective Pictures System...
October 22, 2017: Developmental Science
https://www.readbyqxmd.com/read/29055123/disruption-of-behavior-and-brain-metabolism-in-artificially-reared-rats
#18
Elsa L Aguirre-Benítez, Mercedes G Porras, Leticia Parra, Jacquelina González-Ríos, Dafne F Garduño-Torres, Damaris Albores-García, Arturo Avendaño, Miguel A Ávila-Rodríguez, Angel I Melo, Ismael Jiménez-Estrada, Ma Eugenia Mendoza-Garrido, César Toriz, Daniel Diaz, Elizabeth Ibarra-Coronado, Karina Mendoza-Ángeles, Jesús Hernández-Falcón
Early adverse life stress has been associated to behavioral disorders that can manifest as inappropriate or aggressive responses to social challenges. In this study, we analyzed the effects of artificial rearing on the open field and burial behavioral tests and on GFAP, c-Fos immunoreactivity, and glucose metabolism measured in anxiety-related brain areas. Artificial rearing of male rats was performed by supplying artificial milk through a cheek cannula and tactile stimulation, mimicking the mother's licking to rat pups from the fourth postnatal day until weaning...
December 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29054833/pregnant-women-s-perceptions-of-the-risks-and-benefits-of-disclosure-during-web-based-mental-health-e-screening-versus-paper-based-screening-randomized-controlled-trial
#19
Dawn Kingston, Anne Biringer, Sander Veldhuyzen van Zanten, Rebecca Giallo, Sarah McDonald, Glenda MacQueen, Lydia Vermeyden, Marie-Paule Austin
BACKGROUND: Pregnant women's perceptions of the risks and benefits during mental health screening impact their willingness to disclose concerns. Early research in violence screening suggests that such perceptions may vary by mode of screening, whereby women view the anonymity of e-screening as less risky than other approaches. Understanding whether mode of screening influences perceptions of risk and benefit of disclosure is important in screening implementation. OBJECTIVE: The objective of this randomized controlled trial was to compare the perceptions of pregnant women randomized to a Web-based screening intervention group and a paper-based screening control group on the level of risk and benefit they perceive in disclosing mental health concerns to their prenatal care provider...
October 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29053978/patterns-of-change-in-anxiety-and-depression-during-pregnancy-predict-preterm-birth
#20
Chelsea Doktorchik, Shahirose Premji, Donna Slater, Tyler Williamson, Suzanne Tough, Scott Patten
BACKGROUND: To determine whether changes in anxiety and depression during pregnancy influence the risk of having a preterm birth (PTB), and whether chronic stress modifies this relationship. METHODS: The data source for the current study is the All Our Babies prospective cohort (AOB). Anxiety and depression were measured at 17-24 weeks and again at 32-36 weeks' gestation using the Spielberg State Anxiety Scale and the Edinburgh Postnatal Depression Scale, respectively...
October 2, 2017: Journal of Affective Disorders
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