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Postnatal anxiety

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https://www.readbyqxmd.com/read/28229105/early-life-adversity-lasting-consequences-for-emotional-learning
#1
REVIEW
Harm J Krugers, J Marit Arp, Hui Xiong, Sofia Kanatsou, Sylvie L Lesuis, Aniko Korosi, Marian Joels, Paul J Lucassen
The early postnatal period is a highly sensitive time period for the developing brain, both in humans and rodents. During this time window, exposure to adverse experiences can lastingly impact cognitive and emotional development. In this review, we briefly discuss human and rodent studies investigating how exposure to adverse early life conditions - mainly related to quality of parental care - affects brain activity, brain structure, cognition and emotional responses later in life. We discuss the evidence that early life adversity hampers later hippocampal and prefrontal cortex functions, while increasing amygdala activity, and the sensitivity to stressors and emotional behavior later in life...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28219765/maternal-dipyrone-treatment-during-lactation-in-mice-reduces-maternal-behavior-and-increases-anxiety-like-behavior-in-offspring
#2
Vanessa Barbosa Veronesi, Tatiane Helena Batista, Ana Cláudia Alves Freire Ribeiro, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9...
February 17, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28212519/early-calibration-of-the-hpa-axis-by-maternal-psychopathology
#3
Heidemarie Laurent
Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories...
February 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28197749/the-effect-of-life-style-based-education-on-the-fathers-anxiety-and-depression-during-pregnancy-and-postpartum-periods-a-randomized-controlled-trial
#4
Sakineh Mohammad-Alizadeh Charandabi, Mojgan Mirghafourvand, Fovzieh Sanaati
Due to the harmful effects of prenatal and postnatal anxiety and depression on fathers, the aim of this study was to determine the impact of lifestyle-based training on paternal depression and anxiety (primary outcomes) during the prenatal and postnatal periods. This single-blind randomized controlled clinical trial was conducted on 126 spouses of pregnant women with gestational ages of 24-28 weeks. They were followed up until 6 weeks after childbirth. Using the block randomization method and stratified based on the number of children, the eligible samples were divided into two groups (one receiving two weekly group lifestyle-based training session (lasting 60-90 min) and a control group)...
February 14, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28192175/increased-anxiety-like-phenotype-in-female-guinea-pigs-following-reduced-neurosteroid-exposure-in-utero
#5
Angela L Cumberland, Hannah K Palliser, Gabrielle K Crombie, David W Walker, Jonathan J Hirst
Neurosteroids are essential for aiding proper fetal neurodevelopment. Pregnancy compromises such as preterm birth, prenatal stress and intrauterine growth restriction are associated with an increased risk of developing behavioural and mood disorders, particularly during adolescence. These pathologies involve the premature loss or alteration of trophic steroid hormones reaching the fetus leading to impaired neurodevelopment. While the specific programming mechanisms are yet to be fully elucidated, in adult life, dysfunctions of allopregnanolone action are prevalent in individuals with depression, post-traumatic stress disorder and anxiety disorders...
February 9, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28188472/the-effect-of-postpartum-depression-and-current-mental-health-problems-of-the-mother-on-child-behaviour-at-eight-years
#6
R Closa-Monasterolo, M Gispert-Llaurado, J Canals, V Luque, M Zaragoza-Jordana, B Koletzko, V Grote, M Weber, D Gruszfeld, K Szott, E Verduci, A ReDionigi, J Hoyos, G Brasselle, J Escribano Subías
Background Maternal postpartum depression (PPD) could affect children's emotional development, increasing later risk of child psychological problems. The aim of our study was to assess the association between child's emotional and behavioural problems and mother's PPD, considering maternal current mental health problems (CMP). Methods This is a secondary analysis from the EU-Childhood Obesity Project (NCT00338689). Women completed the Edinburgh Postnatal Depression Scale (EPDS) at, 2, 3 and 6 months after delivery and the General Health Questionnaire (GHQ-12) to assess CMP once the children reached the age of 8 years...
February 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28185885/behavioral-effects-in-adolescence-and-early-adulthood-in-two-length-models-of-maternal-separation-in-male-rats
#7
María Banqueri, Marta Méndez, Jorge L Arias
Maternal separation (MS) is an extensively used early life stress model. There is some variability in the MS lengths used. Maternal separation leads to emotional and behavioral alterations such as anxiety, despair, or memory problems. We performed MS in Wistar rats with two length models from postnatal day 1 until day 10 and from postnatal day 1 until day 21 during 4h per day in both groups. We performed a test battery of a wide range of behaviors to measure anxiety, despair, prepulse inhibition, recognition memory, and associative memory both in adolescent and adult subjects...
February 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28182483/characterization-of-vocalizations-emitted-in-isolation-by-california-mouse-peromyscus-californicus-pups-throughout-the-postnatal-period
#8
Sarah A Johnson, Michele S Painter, Angela B Javurek, Claire R Murphy, Emily C Howald, Zoya Z Khan, Caroline M Conard, Kristal L Gant, Mark R Ellersieck, Frauke Hoffmann, A Katrin Schenk, Cheryl S Rosenfeld
Rodent species, such as monogamous and biparental California mice, produce vocalizations as a means of communication. A temporal examination of vocalizations produced by California mice pups in isolation was performed. Pup recordings were performed for 3 min at ∼10.00 and 14.00 hrs on early postnatal days (PND) 2-4, 7, 21, and 28. Once initial recordings were finished, pups were returned to the home cage with parents and any siblings for 5 minutes to determine if active biparental responses resulted in an enhanced vocalization response when pups were isolated and retested...
February 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28176274/microglial-function-during-glucose-deprivation-inflammatory-and-neuropsychiatric-implications
#9
Matthew A Churchward, Devan R Tchir, Kathryn G Todd
Inflammation is increasingly recognized as a contributor to the pathophysiology of neuropsychiatric disorders, including depression, anxiety disorders and autism, though the factors leading to contextually inappropriate or sustained inflammation in pathological conditions are yet to be elucidated. Microglia, as the key mediators of inflammation in the CNS, serve as likely candidates in initiating pathological inflammation and as an ideal point of therapeutic intervention. Glucose deprivation, as a component of the pathophysiology of ischemia or occurring transiently in diabetes, may serve to modify microglial function contributing to inflammatory injury...
February 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28167438/a-more-rational-theory-driven-approach-to-analysing-the-factor-structure-of-the-edinburgh-postnatal-depression-scale
#10
Zoltan Kozinszky, Annamária Töreki, Emőke A Hompoth, Robert B Dudas, Gábor Németh
We endeavoured to analyze the factor structure of the Edinburgh Postnatal Depression Scale (EPDS) during a screening programme in Hungary, using exploratory (EFA) and confirmatory factor analysis (CFA), testing both previously published models and newly developed theory-driven ones, after a critical analysis of the literature. Between April 2011 and January 2015, a sample of 2967 pregnant women (between 12th and 30th weeks of gestation) and 714 women 6 weeks after delivery completed the Hungarian version of the EPDS in South-East Hungary...
January 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28164167/neonatal-maternal-separation-increases-susceptibility-to-experimental-colitis-and-acute-stress-exposure-in-male-mice
#11
Isabella M Fuentes, Natalie K Walker, Angela N Pierce, Briana R Holt, Elizabeth R Di Silvestro, Julie A Christianson
Experiencing early life stress can result in maladjusted stress response via dysregulation of the hypothalamic-pituitary-adrenal axis and serves as a risk factor for developing chronic pelvic pain disorders. We investigated whether neonatal maternal separation (NMS) would increase susceptibility to experimental colitis or exposure to acute or chronic stress. Male mice underwent NMS from postnatal day 1-21 and as adults were assessed for open field behavior, hindpaw sensitivity, and visceromotor response (VMR) to colorectal distension (CRD)...
December 2016: IBRO Rep
https://www.readbyqxmd.com/read/28163104/age-dependent-regulation-of-gaba-transmission-by-kappa-opioid-receptors-in-the-basolateral-amygdala-of-sprague-dawley-rats
#12
K R Przybysz, D F Werner, M R Diaz
Anxiety disorders are one of the most common and debilitating mental illnesses worldwide. Growing evidence indicates an age-dependent rise in the incidence of anxiety disorders from adolescence through adulthood, suggestive of underlying neurodevelopmental mechanisms. Kappa opioid receptors (KORs) are known to contribute to the development and expression of anxiety; however, the functional role of KORs in the basolateral amygdala (BLA), a brain structure critical in mediating anxiety, particularly across ontogeny, are unknown...
February 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28150086/morphological-structural-and-functional-alterations-of-the-prefrontal-cortex-and-the-basolateral-amygdala-after-early-lesion-of-the-rat-mediodorsal-thalamus
#13
Zakaria Ouhaz, Saadia Ba-M'hamed, Mohamed Bennis
Early postnatal damage to the mediodorsal thalamus (MD) produces deficits in cognition and behavior believed to be associated with early prefrontal cortical maldevelopment. We assessed the role of MD afferents during development on the morphological and functional maturation of the prefrontal cortex (PFC) and the basolateral amygdala (BLA). Sprague-Dawley rat pups (n = 56) received a bilateral electrolytic lesion of the MD or a MD Sham lesion on postnatal day 4. 7 weeks later, all rats were tested in anxiety-related and cognitive paradigms using the elevated plus maze and novel object recognition tests...
February 1, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28135275/validity-and-acceptability-of-kimberley-mum-s-mood-scale-to-screen-for-perinatal-anxiety-and-depression-in-remote-aboriginal-health-care-settings
#14
Julia V Marley, Jayne Kotz, Catherine Engelke, Melissa Williams, Donna Stephen, Sudha Coutinho, Stephanie K Trust
BACKGROUND: The Edinburgh Postnatal Depression Scale (EPDS) is widely recommended for perinatal anxiety and depression screening. However, many Aboriginal women find EPDS language complex and confusing, and providers find using it with Aboriginal women challenging. The two part Kimberley Mum's Mood Scale (KMMS) was developed to improve screening: Part 1 is a Kimberley version of EPDS; Part 2 is a psychosocial tool that enables contextualisation of Part 1 scores. We aimed to determine if KMMS is a valid and acceptable method of identifying Kimberley Aboriginal perinatal women at risk of anxiety or depressive disorders compared to a semi-structured clinical interview...
2017: PloS One
https://www.readbyqxmd.com/read/28132000/computerised-cognitive-behavioural-therapy-for-depression-in-adolescents-feasibility-results-and-4-month-outcomes-of-a-uk-randomised-controlled-trial
#15
Barry Wright, Lucy Tindall, Elizabeth Littlewood, Victoria Allgar, Paul Abeles, Dominic Trépel, Shehzad Ali
OBJECTIVES: Computer-administered cognitive-behavioural therapy (CCBT) may be a promising treatment for adolescents with depression, particularly due to its increased availability and accessibility. The feasibility of delivering a randomised controlled trial (RCT) comparing a CCBT program (Stressbusters) with an attention control (self-help websites) for adolescent depression was evaluated. DESIGN: Single centre RCT feasibility study. SETTING: The trial was run within community and clinical settings in York, UK...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28128679/early-life-stress-links-5-hydroxymethylcytosine-to-anxiety-related-behaviors
#16
Ligia A Papale, Andy Madrid, Sisi Li, Reid S Alisch
Environmental stress contributes to the development of psychiatric disorders, including post-traumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-hydroxymethylcytosine (5hmC) is a novel environmentally sensitive DNA modification that is highly enriched in the brain and is associated with active transcription of neuronal genes. Here we examined behavioral and molecular alterations in adult mice that experienced an early-life stress prior to weaning (postnatal day 12 to 18) and found anxiety-like behaviors in adult female mice that were accompanied by correlated disruptions of hypothalamic 5hmC and gene expression in 118 genes, revealing potentially functional 5hmC (i...
January 27, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28125983/fathers-views-and-experiences-of-their-own-mental-health-during-pregnancy-and-the-first-postnatal-year-a-qualitative-interview-study-of-men-participating-in-the-uk-born-and-bred-in-yorkshire-baby-cohort
#17
Z Darwin, P Galdas, S Hinchliff, E Littlewood, D McMillan, L McGowan, S Gilbody
BACKGROUND: The prevalence of fathers' depression and anxiety in the perinatal period (i.e. from conception to 1 year after birth) is approximately 5-10%, and 5-15%, respectively; their children face increased risk of adverse emotional and behavioural outcomes, independent of maternal mental health. Critically, fathers can be protective against the development of maternal perinatal mental health problems and their effects on child outcomes. Preventing and treating paternal mental health problems and promoting paternal psychological wellbeing may therefore benefit the family as a whole...
January 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28122520/postnatal-depression-screening-in-a-paediatric-primary-care-setting-in-italy
#18
Antonio Clavenna, Elena Seletti, Massimo Cartabia, Anna Didoni, Filomena Fortinguerra, Teresa Sciascia, Luca Brivio, Daniela Malnis, Maurizio Bonati
BACKGROUND: Postnatal depression is a non-psychotic depressive disorder that begins within 4 weeks of childbirth and occurs in 13% of mothers and 10% of fathers. A prospective study with the aim to evaluate the prevalence of postnatal depression by screening parents with the Edinburgh Postnatal Depression Scale (EPDS) in the Italian paediatric primary care setting was performed. METHODS: Mothers and fathers of infants born between 1 February and 31 July 2012, living in Italy's Milan-1 local health unit area, represented the target population of this pilot study...
January 25, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28120519/mercy-pregnancy-and-emotional-well-being-study-mpews-understanding-maternal-mental-health-fetal-programming-and-child-development-study-design-and-cohort-profile
#19
Megan Galbally, Marinus van IJzendoorn, Michael Permezel, Richard Saffery, Martha Lappas, Joanne Ryan, Elisabeth van Rossum, Andrew R Johnson, Douglas Teti, Andrew J Lewis
Maternal mental health represents a significant global health burden. The Mercy Pregnancy and Emotional Well-being Study (MPEWS) was established to provide a comprehensive investigation of early developmental mechanisms and modifiers for maternal, fetal and child emotional well-being. MPEWS is a prospective, longitudinal study from pregnancy to 36 months postpartum that includes diagnostic measures of maternal mental health, observational measures of the mother-infant relationship, measures of child development, and repeat biological sampling...
January 25, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28111254/neonatal-blockade-of-gaba-a-receptors-alters-behavioral-and-physiological-phenotypes-in-adult-mice
#20
Ali-Akbar Salari, Mohammad Amani
Gamma-aminobutyric acid (GABA) plays an inhibitory role in the mature brain, and has a complex and bidirectional effect in different parts of the immature brain which affects proliferation, migration and differentiation of neurons during development. There is also increasing evidence suggesting that activation or blockade of the GABA-A receptors during early life can induce brain and behavioral abnormalities in adulthood. We investigated whether neonatal blockade of the GABA-A receptors by bicuculline can alter anxiety- and depression-like behaviors, body weight, food intake, corticosterone and testosterone levels in adult mice (postnatal days 80-95)...
January 19, 2017: International Journal of Developmental Neuroscience
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