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https://www.readbyqxmd.com/read/28795135/male-and-female-mice-lacking-neuroligin-3-modify-the-behavior-of-their-wild-type-littermates
#1
Shireene Kalbassi, Sven O Bachmann, Ellen Cross, Victoria H Roberton, Stéphane J Baudouin
In most mammals, including humans, the postnatal acquisition of normal social and nonsocial behavior critically depends on interactions with peers. Here we explore the possibility that mixed-group housing of mice carrying a deletion of Nlgn3, a gene associated with autism spectrum disorders, and their wild-type littermates induces changes in each other's behavior. We have found that, when raised together, male Nlgn3 knockout mice and their wild-type littermates displayed deficits in sociability. Moreover, social submission in adult male Nlgn3 knockout mice correlated with an increase in their anxiety...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28780475/the-postpartum-partner-support-scale-development-psychometric-assessment-and-predictive-validity-in-a-canadian-prospective-cohort
#2
Cindy-Lee Dennis, Hilary K Brown, Sarah Brennenstuhl
BACKGROUND: postpartum depression is a significant public health issue with well-documented negative consequences. A strong risk factor that has been consistently identified in international samples is a poor partner relationship. However, no instrument exists to measure postpartum-specific partner support. OBJECTIVES: the objective of this methodological study was to develop and psychometrically test an instrument to assess the perception of postpartum partner support to guide interventions...
July 29, 2017: Midwifery
https://www.readbyqxmd.com/read/28776105/improving-help-seeking-for-postnatal-depression-and-anxiety-a-cluster-randomised-controlled-trial-of-motivational-interviewing
#3
Charlene Holt, Jeannette Milgrom, Alan W Gemmill
Low uptake of treatment by women with symptoms of postnatal depression and anxiety is consistently reported. This study examined whether a brief motivational interviewing (MI) intervention delivered by Maternal and Child Health Nurses (MCHNs) during routine emotional health assessments improves help-seeking following childbirth. In this parallel two-group cluster randomised controlled trial, MCHNs delivered a MI intervention ('PRIMER', n = 20) or Routine Care (n = 20) at women's (n = 541) postnatal consultations...
August 3, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28770342/subconstructs-of-the-edinburgh-postnatal-depression-scale-in-a-multi-ethnic-inner-city-population-in-the-u-s
#4
Yueh-Hsiu Mathilda Chiu, Perry E Sheffield, Hsiao-Hsien Leon Hsu, Jonathan Goldstein, Paul C Curtin, Rosalind J Wright
The ten-item Edinburgh Postnatal Depression Scale (EPDS) is one of the most widely used self-report measures of postpartum depression. Although originally described as a one-dimensional measure, the recognition that depressive symptoms may be differentially experienced across cultural and racial/ethnic groups has led to studies examining structural equivalence of the EPDS in different populations. Variation of the factor structure remains understudied across racial/ethnic groups of US women. We examined the factor structure of the EPDS assessed 6 months postpartum in 515 women (29% black, 53% Hispanic, 18% white) enrolled in an urban Boston longitudinal birth cohort...
August 2, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28769788/association-between-cyp2d6-genotypes-and-the-risk-of-antidepressant-discontinuation-dosage-modification-and-the-occurrence-of-maternal-depression-during-pregnancy
#5
Anick Bérard, Andrea Gaedigk, Odile Sheehy, Christina Chambers, Mark Roth, Pina Bozzo, Diana Johnson, Kelly Kao, Sharon Lavigne, Lori Wolfe, Dee Quinn, Kristen Dieter, Jin-Ping Zhao
Importance: Polymorphic expression of drug metabolizing enzymes affects the metabolism of antidepressants, and thus can contribute to drug response and/or adverse events. Pregnancy itself can affect CYP2D6 activity with profound variations determined by CYP2D6 genotype. Objective: To investigate the association between CYP2D6 genotype and the risk of antidepressant discontinuation, dosage modification, and the occurrence of maternal CYP2D6, Antidepressants, Depression during pregnancy. Setting: Data from the Organization of Teratology Information Specialists (OTIS) Antidepressants in Pregnancy Cohort, 2006-2010, were used...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28767135/phenotypic-outcomes-in-adolescence-and-adulthood-in-the-scarcity-adversity-model-of-low-nesting-resources-outside-the-home-cage
#6
Tiffany S Doherty, Jennifer Blaze, Samantha M Keller, Tania L Roth
Early life adversity is known to disrupt behavioral trajectories and many rodent models have been developed to characterize these stress-induced outcomes. One example is the scarcity-adversity model of low nesting resources. This model employs resource scarcity (i.e., low nesting materials) to elicit adverse caregiving conditions (including maltreatment) toward rodent neonates. Our lab utilizes a version of this model wherein caregiving exposures occur outside the home cage during the first postnatal week. The aim of this study was to determine adolescent and adult phenotypic outcomes associated with this model, including assessment of depressive- and anxiety-like behaviors and performance in different cognitive domains...
August 2, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28755859/systemic-inflammation-combined-with-neonatal-cerebellar-haemorrhage-aggravates-long-term-structural-and-functional-outcomes-in-a-mouse-model
#7
Sophie Tremblay, Alex Pai, Lindsay Richter, Rod Vafaei, Praneetha Potluri, Jacob Ellegood, Jason P Lerch, Daniel Goldowitz
BACKGROUND: Despite the increased recognition of cerebellar injury in survivors of preterm birth, the neurodevelopmental consequences of isolated cerebellar injury have been largely unexplored and our current understanding of the functional deficits requires further attention in order to translate knowledge to best practices. Preterm infants are exposed to multiple stressors during their postnatal development including perinatal cerebellar haemorrhage (CBH) and postnatal infection, two major risk factors for neurodevelopmental impairments...
July 27, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28755039/differential-predictors-of-postpartum-depression-and-anxiety-the-edinburgh-postnatal-depression-scale-hebrew-version-two-factor-structure-construct-validity
#8
Rena Bina, Donna Harrington
Objectives Postpartum anxiety (PPA) is as prevalent and disruptive as postpartum depression (PPD), although less commonly addressed. The Edinburgh Postnatal Depression Scale (EPDS), originally created to screen for PPD, was found to include anxiety and depression subscales. This study examined the construct validity of the EPDS PPD and PPA subscales by examining differential predictors of both in a structural regression model. Methods Women (n = 969) were recruited from a maternity ward in Jerusalem, Israel and completed a demographic survey; 715 (74%) women were screened for PPD and PPA at 6 weeks postpartum using the EPDS...
July 28, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28751351/intrusive-thoughts-and-images-of-intentional-harm-to-infants-in-the-context-of-maternal-postnatal-depression-anxiety-and-ocd
#9
Peter J Lawrence, Michelle G Craske, Claire Kempton, Anne Stewart, Alan Stein
No abstract text is available yet for this article.
August 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28749705/associations-between-postpartum-depression-breastfeeding-and-oxytocin-levels-in-latina-mothers
#10
Sandraluz Lara-Cinisomo, Kathryn McKenney, Arianna Di Florio, Samantha Meltzer-Brody
BACKGROUND: Postpartum depression (PPD), often comorbid with anxiety, is the leading medical complication among new mothers. Latinas have elevated risk of PPD, which has been associated with early breastfeeding cessation. Lower plasma oxytocin (OT) levels have also been associated with PPD in non-Latinas. This pilot study explores associations between PPD, anxiety, breastfeeding, and OT in Latinas. MATERIALS AND METHODS: Thirty-four Latinas were enrolled during their third trimester of pregnancy and followed through 8 weeks postpartum...
July 27, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28748744/prevalence-incidence-and-persistence-of-postpartum-depression-anxiety-and-comorbidity-among-chinese-immigrant-and-nonimmigrant-women-a-longitudinal-cohort-study
#11
Cindy-Lee Dennis, Hilary K Brown, Susitha Wanigaratne, Kenneth Fung, Simone N Vigod, Sophie Grigoriadis, Flavia Marini, Sarah Brennenstuhl
OBJECTIVE: Our objectives were to examine the prevalence and incidence of postpartum depressive, anxiety, and comorbid symptoms over the first postpartum year; the persistence of these symptoms; and the prevalence stratified by immigration status. METHOD: We conducted a longitudinal cohort study in Ontario, Canada. Participants were 571 Chinese recent immigrant, nonrecent immigrant, and Canadian-born women with live births in 2011 to 2014. Participants were assessed at 4, 12, and 52 weeks postpartum for the presence of possible and high depressive symptomatology (Edinburgh Postnatal Depression Scale [EPDS] >9 and >12, respectively), anxiety symptomatology (State-Trait Anxiety Inventory [STAI] >40), and comorbid symptomatology (EPDS >9 and STAI >40)...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28737195/-maternal-postnatal-depression-and-its-impact-on-child-neurodevelopment-a-cohort-study
#12
Gabriel González, Mario Moraes, Claudio Sosa, Eleuterio Umpierrez, María Duarte, José Cal, Andrea Ghione
Post partum depresion (DPP) is the most frequent psquiatric disorder in pregnant woman and it may affect the neurodevelopment of their offspring. Our goal was to analyze the association between maternal depressive symptoms at 6 months after birth and child’s neurodevelopmental disorders at 18 months-old, in a homogeneous population characterized by low socioeconomic and cultural level. PATIENTS AND METHODS: A prospective cohort study was conducted. There were included 127 healthy postpartum women and their infants...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28709777/fear-of-childbirth-in-primiparous-italian-pregnant-women-the-role-of-anxiety-depression-and-couple-adjustment
#13
Sara Molgora, Valentina Fenaroli, Laura Elvira Prino, Luca Rollè, Cristina Sechi, Annamaria Trovato, Laura Vismara, Barbara Volpi, Piera Brustia, Loredana Lucarelli, Renata Tambelli, Emanuela Saita
BACKGROUND: The prevalence of fear of childbirth in pregnant women is described to be about 20-25%, while 6-10% of expectant mothers report a severe fear that impairs their daily activities as well as their ability to cope with labour and childbirth. Research on fear of childbirth risk factors has produced heterogeneous results while being mostly done with expectant mothers from northern Europe, northern America, and Australia. AIMS: The present research investigates whether fear of childbirth can be predicted by socio-demographic variables, distressing experiences before pregnancy, medical-obstetric factors and psychological variables with a sample of 426 Italian primiparous pregnant women...
July 11, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28707502/appraisal-of-the-psychiatric-diagnostic-screening-questionnaire-in-a-perinatal-cohort-the-apron-study
#14
Brenda Leung, Nicole Letourneau, Katherine Bright, Gerald F Giesbrecht, Henry Ntanda, Lisa Gagnon
BACKGROUND: Depression and anxiety are routinely screened as part of perinatal care. However, other Axis 1 disorders and specific anxiety disorders are less likely to be screened or assessed as part of obstetric care. The objective of this study was to determine whether the Psychiatric Diagnostic Screening Questionnaire (PDSQ) is a potentially useful tool to screen for psychiatric conditions in pregnant and postpartum women in a community setting. METHODS: We compared the prevalence of DSM Axis I disorders obtained on the PDSQ with: (1) the prevalence of these disorders reported in previous studies of pregnant and postpartum women, and (2) scores obtained on the Edinburgh Postpartum Depression Scale (EPDS) and the Symptom Checklist-90-Revised (SCL-90R) anxiety scale...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28705472/adolescent-social-isolation-affects-schizophrenia-like-behavior-and-astrocyte-biomarkers-in-the-pfc-of-adult-rats
#15
Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao, Weiwen Wang
Social isolation is regarded as a cause of schizophrenia spectrum disorders. Animal models of schizophrenia are constructed by repeated early environment deprivation as an important paradigm to reveal its pathological mechanism. Male Sprague Dawley rats were assigned to either social-rearing (SR) or isolated-rearing (IR) groups during postnatal days (PNDs) 21-34. On PND 56, all rats underwent behavioral testing including locomotor activity, anxiety-related behaviors in an open field and prepulse inhibition (PPI)...
July 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28695280/effect-of-post-weaning-isolation-on-anxiety-and-depressive-like-behaviors-of-c57bl-6j-mice
#16
Qian Huang, Ying Zhou, Lin-Yun Liu
Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field...
July 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28686282/early-maternal-separation-induces-preference-for-sucrose-and-aspartame-associated-with-increased-blood-glucose-and-hyperactivity
#17
L Aya-Ramos, C Contreras-Vargas, J L Rico, Z Dueñas
Early life stress and exposure to sweeteners lead to physiological and behavioral alterations in adulthood. Nevertheless, many genetic and environmental factors as well as the neurobiological mechanisms that contribute to the development of these disorders are not fully understood. Similarly, evidence about the long-term metabolic effects of exposure to sweeteners in early life is limited and inconsistent. This study used an animal model of maternal separation during breastfeeding (MS) to analyze the effects of early life stress on consumption of sweeteners, weight gain, blood glucose and locomotion...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28680154/the-adverse-effects-of-auditory-stress-on-mouse-uterus-receptivity-and-behaviour
#18
Zahra Jafari, Jamshid Faraji, Behroo Mirza Agha, Gerlinde A S Metz, Bryan E Kolb, Majid H Mohajerani
Stress during gestation has harmful effects on pregnancy outcome and can lead to spontaneous abortion. Few studies, however, have addressed the impact of gestational stress, particularly auditory stress, on behavioural performance and pregnancy outcome in mice. This study aimed to examine the effect of two types of gestational stress on uterus receptivity and behavioural performance. Pregnant C57BL/6 mice were randomly assigned to either auditory or physical stress conditions or a control condition from gestational days 12-16...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28667832/effect-of-previous-posttraumatic-stress-in-the-perinatal-period
#19
Pamela A Geller, Emily C Stasko
OBJECTIVE: To review the extant literature on the effect of traumatic experiences that pre-date conception, pregnancy, and the postpartum period (perinatal period) and present a thematic overview of current issues in this relatively new area of inquiry. DATA SOURCES: Electronic databases CINAHL, PsychINFO, and PubMed were searched. Manual searches of bibliographies supplemented the electronic search. STUDY SELECTION: Peer-reviewed articles written in English on the role of posttraumatic stress disorder during the perinatal period were included...
June 28, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28662698/mov10-suppresses-retroelements-and-regulates-neuronal-development-and-function-in-the-developing-brain
#20
Geena Skariah, Joseph Seimetz, Miles Norsworthy, Monica C Lannom, Phillip J Kenny, Mohamed Elrakhawy, Craig Forsthoefel, Jenny Drnevich, Auinash Kalsotra, Stephanie Ceman
BACKGROUND: Moloney leukemia virus 10 (Mov10) is an RNA helicase that mediates access of the RNA-induced silencing complex to messenger RNAs (mRNAs). Until now, its role as an RNA helicase and as a regulator of retrotransposons has been characterized exclusively in cell lines. We investigated the role of Mov10 in the mouse brain by examining its expression over development and attempting to create a Mov10 knockout mouse. Loss of both Mov10 copies led to early embryonic lethality. RESULTS: Mov10 was significantly elevated in postnatal murine brain, where it bound retroelement RNAs and mRNAs...
June 29, 2017: BMC Biology
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