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Endothelial progenitor cell

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https://www.readbyqxmd.com/read/28103599/evaluations-of-intravenous-administration-of-cd34-human-umbilical-cord-blood-cells-in-a-mouse-model-of-neonatal-hypoxic-ischemic-encephalopathy
#1
Makiko Ohshima, Akihiko Taguchi, Yoshiaki Sato, Yuko Ogawa, Satoshi Saito, Kenichi Yamahara, Masafumi Ihara, Mariko Harada-Shiba, Tomoaki Ikeda, Tomohiro Matsuyama, Masahiro Tsuji
Several cell therapies have been explored as novel therapeutic strategies for neonatal encephalopathy because the benefits of current treatments are limited. We previously reported that intravenous administration of human umbilical cord blood (hUCB) CD34+ cells (hematopoietic stem cells/endothelial progenitor cells) at 48 h after insult exerts therapeutic effects in neonatal mice with stroke, i.e., permanent middle cerebral artery occlusion. Although neonatal stroke and hypoxic-ischemic encephalopathy (HIE) are grouped under the term "neonatal encephalopathy," their pathogenesis differs...
January 20, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28100488/kinetic-analyses-of-vasculogenesis-inform-mechanistic-studies
#2
Kaela M Varberg, Seth Winfree, Chenghao Chu, Wanzhu Tu, Emily K Blue, Cassandra R Gohn, Kenneth W Dunn, Laura S Haneline
Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell (EPC) functionality. However, current assays lack kinetic measurements. To address this issue, new approaches were developed to quantitatively assess in vitro endothelial colony forming cell (ECFC) network formation in real time. Eight parameters of network structure were quantified using novel Kinetic Analysis of Vasculogenesis (KAV) software...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28100233/the-role-of-the-endothelium-in-asthma-and-chronic-obstructive-pulmonary-disease-copd
#3
REVIEW
Clara E Green, Alice M Turner
COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its' progenitor cells behave in a dysfunctional manner...
January 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28100035/stromal-cells-act-as-guardians-for-endothelial-progenitors-by-reducing-their-immunogenicity-after-co-transplantation
#4
Naima Souidi, Meaghan Stolk, Juliane Rudeck, Dirk Strunk, Katharina Schallmoser, Hans-Dieter Volk, Martina Seifert
Regeneration of injured tissues requires effective therapeutic strategies supporting vasculogenesis. The lack of instantly available autologous cell sources and immunogenicity of allogeneic endothelial (progenitor) cells limits clinical progress. Based on the immunosuppressive potency of mesenchymal strem/progenitor cells (MSCs), we investigated whether crosstalk between endothelial colony-forming progenitor cells (ECFCs) and MSCs during vasculogenesis could lower allogeneic T cell responses against ECFCs allowing long-term engraftment in vivo...
January 18, 2017: Stem Cells
https://www.readbyqxmd.com/read/28096213/endothelial-cell-regulation-of-salivary-gland-epithelial-patterning
#5
Hae Ryong Kwon, Deirdre A Nelson, Kara A DeSantis, Jennifer M Morrissey, Melinda Larsen
Perfusion-independent regulation of epithelial pattern formation by the vasculature during organ development and regeneration is of considerable interest for application in restoring organ function. During murine submandibular salivary gland development, the vasculature co-develops with the epithelium during branching morphogenesis; however, it is not known whether the vasculature has instructive effects on the epithelium. Using pharmacological inhibitors and siRNA knockdown in embryonic organ explants, we determined that VEGFR2-dependent signaling is required for salivary gland epithelial patterning...
January 15, 2017: Development
https://www.readbyqxmd.com/read/28095743/adult-murine-pancreatic-progenitors-require-egf-and-nicotinamide-for-self-renewal-and-differentiation-in-a-serum-and-conditioned-medium-free-culture
#6
Lena Wedeken, Angela Luo, Jacob R Tremblay, Jeffrey Rawson, Liang Jin, Dan Gao, Janine Quijano, Hsun Teresa Ku
Adult pancreatic stem and progenitor cells may serve as an alternative source of insulin-secreting endocrine cells in cell replacement therapy for type 1 diabetes, but much remained unknown about these cells. We previously identified adult murine pancreatic progenitor-like cells that displayed in vitro self-renewal and tri-lineage differentiation activities in a 3-dimensional colony/organoid assay containing 1% methylcellulose and 5% Matrigel. However, the presence of other undefined culture components, such as serum and conditioned medium, has prevented a complete understanding of the signals required for progenitor cell growth...
January 17, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28093678/changes-in-serum-vascular-endothelial-growth-factor-and-endostatin-concentrations-associated-with-circulating-endothelial-progenitor-cells-after-acute-ischemic-stroke
#7
Lixia Xue, Hao Chen, Ting Zhang, Jingjiong Chen, Zhi Geng, Yuwu Zhao
Angiogenesis is an important pathophysiological response to cerebral ischemia, and can be modulated by vascular endothelial growth factor (VEGF) and endostatin. Circulating endothelial progenitor cells (EPCs) also play an important role as an endogenous repair mechanism for ischemic injury. We sought to investigate early changes in the expression of VEGF and endostatin in serum and the circulating EPCs in patients with acute ischemic stroke (AIS) and analyzed the relations between them. The peripheral blood and serum samples were obtained from 30 patients at 1, 3, 5 and 7 d after AIS...
January 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28093175/re-treatment-of-diabetes-mellitus-induced-erectile-dysfunction-using-endothelial-progenitor-cells-genetically-modified-with-human-telomerase-reverse-transcriptase
#8
https://www.readbyqxmd.com/read/28091913/regenerative-potential-of-stem-and-progenitor-cells-from-ischemic-testes-of-c57bl-6-mice-in-culture-and-in-the-model-of-spermatogenesis-suppression-caused-by-busulfan
#9
E G Skurikhin, A V Pakhomova, O V Pershina, L A Ermolaeva, N N Ermakova, V A Krupin, E S Pan, A I Kudryashova, O Yu Rybalkina, V V Zhdanov, V E Goldberg, A M Dygai
The regenerative potential of stem and progenitor cells from ischemic testes of C57Bl/6 mice was studied in vitro (cell culture) and in vivo (mouse model of busulfan-induced suppression of spermatogenesis). Spermatogonial stem cells with phenotypes CD117(-)CD90(+) and CD51(-)CD24(+)CD52(+) from ischemic testes demonstrated 33-fold and 7-fold increments of cell mass and generated colonies in vitro. Epithelial (CD45(-)CD31(-)Sca-1(+)CD49f(+)) and endothelial (CD45(-)CD31(+)) precursors exhibited lower self-renewal capacity...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28090699/modelling-irf8-deficient-human-hematopoiesis-and-dendritic-cell-development-with-engineered-ips-cells
#10
Stephanie Sontag, Malrun Förster, Jie Qin, Paul Wanek, Saskia Mitzka, Herdit M Schüler, Steffen Koschmieder, Stefan Rose-John, Kristin Seré, Martin Zenke
Human induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers, including hematopoietic stem cells and their progeny. Interferon regulatory factor 8 (IRF8) is a transcription factor, which acts in hematopoiesis as lineage determining factor for myeloid cells, including dendritic cells (DC). Autosomal recessive or dominant IRF8 mutations occurring in patients cause severe monocytic and DC immunodeficiency. To study IRF8 in human hematopoiesis we generated human IRF8-/- iPS cells and IRF8-/- embryonic stem (ES) cells using RNA guided CRISPR/Cas9n genome editing...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28090691/peg3-pw1-is-a-marker-of-a-subset-of-vessel-associated-endothelial-progenitors
#11
Matteo Malinverno, Monica Corada, Luca Ferrarini, Luigi Formicola, Giovanna Marazzi, David Sassoon, Elisabetta Dejana
Vascular associated endothelial cell progenitors are still poorly studied and their role in the newly forming vasculature at embryonic or postnatal stage remains elusive. In the present work we first defined a set of genes highly expressed during embryo development and strongly down regulated in the adult mouse. In this group we then concentrated on the progenitor cell marker Peg3/PW1. By in vivo staining of the vasculature we found that only a subset of cells co-expressed endothelial markers and PW1. These cells were quite abundant in the embryo vasculature but declined in number at postnatal and adult stages...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28089145/effect-of-exercise-training-on-endothelial-function-in-heart-failure-patients-a-systematic-review-meta-analysis
#12
M J Pearson, N A Smart
OBJECTIVE: Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure. BACKGROUND: A large number of studies now exist that have examined endothelial function in patients with heart failure...
December 28, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28078807/traumatized-muscle-derived-multipotent-progenitor-cells-recruit-endothelial-cells-through-vascular-endothelial-growth-factor-a-action
#13
Heidi R H Supanc, Shannon Gorman, Rocky S Tuan
Traumatized muscle, such as that debrided from blast injury sites, is considered a promising and convenient tissue source for multipotent progenitor cells (MPCs), a population of adult mesenchymal stem cell (MSC)-like cells. The present study aimed to assess the regenerative therapeutic potential of human traumatized muscle-derived MPCs, e.g., for injury repair in the blast-traumatized extremity, by comparing their pro-angiogenic potential in vitro and capillary recruitment activity in vivo to those of MSCs isolated from human bone marrow, a widely-used tissue source...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28078527/circulating-endothelial-progenitor-cells-in-crohn-s-disease-an-epic-in-the-making
#14
EDITORIAL
Catharine Dietrich, Shree Ram Singh
No abstract text is available yet for this article.
January 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28074532/pathogenesis-of-developmental-anomalies-of-the-central-nervous-system-induced-by-congenital-cytomegalovirus-infection
#15
REVIEW
Hideya Kawasaki, Isao Kosugi, Shiori Meguro, Toshihide Iwashita
In humans, the herpes virus family member cytomegalovirus (CMV) is the most prevalent mediator of intrauterine infection-induced congenital defect. Central nervous system (CNS) dysfunction is a distinguishing symptom of CMV infection, and characterized by ventriculoencephalitis and microglial nodular encephalitis. Reports on the initial distribution of CMV particles and its receptors on the blood brain barrier (BBB) are rare. Nevertheless, several factors are suggested to affect CMV etiology. Viral particle size is the primary factor in determining the pattern of CNS infections, followed by the expression of integrin β1 in endothelial cells, pericytes, meninges, choroid plexus, and neural stem progenitor cells (NSPCs), which are the primary targets of CMV infection...
January 10, 2017: Pathology International
https://www.readbyqxmd.com/read/28072843/chemokine-ligand-5-ccl5-derived-from-endothelial-colony-forming-cells-ecfcs-mediates-recruitment-of-smooth-muscle-progenitor-cells-spcs-toward-critical-vascular-locations-in-moyamoya-disease
#16
Ji Hoon Phi, Naoko Suzuki, Youn Joo Moon, Ae Kyung Park, Kyu-Chang Wang, Ji Yeoun Lee, Seung-Ah Choi, Sangjoon Chong, Reizo Shirane, Seung-Ki Kim
The etiology and pathogenesis of moyamoya disease (MMD) are still obscure. Previous studies indicated that angiogenic chemokines may play an important role in the pathogenesis of the disease. Recently, it was discovered that peripheral blood-derived endothelial colony-forming cells (ECFCs) and smooth muscle progenitor cells (SPCs) have defective functions in MMD patients. Therefore, the interaction of ECFCs and SPCs, the precursors of two crucial cellular components of vascular walls, with some paracrine molecules is an intriguing subject...
2017: PloS One
https://www.readbyqxmd.com/read/28070997/involvement-of-endothelial-progenitor-cells-in-the-formation-of-plexiform-lesions-in-broiler-chickens-possible-role-of-local-immune-inflammatory-response
#17
Xun Tan, Fan-Guo Juan, Ali Q Shah
Plexiform lesions (PLs), which are often accompanied by perivascular infiltrates of mononuclear cells, represent the hallmark lesions of pulmonary arteries in humans suffering from severe pulmonary arterial hypertension (PAH). Endothelial progenitor cells (EPCs) have been recently implicated in the formation of PLs in human patients. PLs rarely develop in rodent animal models of PAH but can develop spontaneously in broiler chickens. The aim of the present study was to confirm the presence of EPCs in the PLs in broilers...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28070752/absence-of-macrophage-migration-inhibitory-factor-reduces-proliferative-retinopathy-in-a-mouse-model
#18
Jing Wang, Jihong Lin, Ulrike Kaiser, Paulus Wohlfart, Hans-Peter Hammes
AIMS: Ischemia-induced neovascularization is the key feature of proliferative diabetic retinopathy. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory and proangiogenic cytokine, and its levels are elevated in the vitreous of patients with proliferative diabetic retinopathy. In this study, we aimed at investigating the relative potential of MIF in the ischemia-induced retinal neovascularization. METHODS: Both WT and MIF-knockout mice were subjected to the retinopathy of prematurity (ROP) model...
January 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28066993/developing-a-biomimetic-tooth-bud-model
#19
Elizabeth E Smith, Weibo Zhang, Nathan R Schiele, Ali Khademhosseini, Catherine K Kuo, Pamela C Yelick
A long-term goal is to bioengineer, fully functional, living teeth for regenerative medicine and dentistry applications. Biologically based replacement teeth would avoid insufficiencies of the currently used dental implants. Using natural tooth development as a guide, a model was fabricated using post-natal porcine dental epithelial (pDE), porcine dental mesenchymal (pDM) progenitor cells, and human umbilical vein endothelial cells (HUVEC) encapsulated within gelatin methacrylate (GelMA) hydrogels. Previous publications have shown that post-natal DE and DM cells seeded onto synthetic scaffolds exhibited mineralized tooth crowns composed of dentin and enamel...
January 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28062497/increased-proangiogenic-activity-of-mobilized-cd34-progenitor-cells-of-patients-with-acute-st-segment-elevation-myocardial-infarction-role-of-differential-micro-rna-378-expression
#20
Christian Templin, Julia Volkmann, Maximilian Y Emmert, Pavani Mocharla, Maja Müller, Nicolle Kraenkel, Jelena R Ghadri, Martin Meyer, Beata Styp-Rekowska, Sylvie Briand, Roland Klingenberg, Milosz Jaguszewski, Christian M Matter, Valentin Djonov, Francois Mach, Stephan Windecker, Simon P Hoerstrup, Thomas Thum, Thomas F Lüscher, Ulf Landmesser
OBJECTIVE: Proangiogenic effects of mobilized bone marrow-derived stem/progenitor cells are essential for cardiac repair after myocardial infarction. Micro-RNAs (miRNA/miR) are key regulators of angiogenesis. We investigated the differential regulation of angio-miRs, that is, miRNAs regulating neovascularization, in mobilized CD34(+) progenitor cells obtained from patients with an acute ST-segment-elevation myocardial infarction (STEMI) as compared with those with stable coronary artery disease or healthy subjects...
December 29, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
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