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Gastrointestinal illness

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https://www.readbyqxmd.com/read/29155976/description-of-a-mass-poisoning-in-a-rural-district-in-mozambique-the-first-documented-bongkrekic-acid-poisoning-in-africa
#1
Eduardo Samo Gudo, Kyla Cook, Amelia M Kasper, Alfredo Vergara, Cristolde Salomão, Fernanda Oliveira, Hamida Ismael, Cristovão Saeze, Carla Mosse, Quinhas Fernandes, Sofia Omar Viegas, Cynthia S Baltazar, Timothy J Doyle, Ellen Yard, Alaina Steck, Mayda Serret, Travis M Falconer, Sara E Kern, Jennifer L Brzezinski, James A Turner, Brian L Boyd, Ilesh V Jani
Background: On January 9, 2015, in a rural town in Mozambique, over 230 people became sick and 75 died from an illness linked to drinking pombe, a traditional alcoholic beverage. Methods: An investigation was conducted to identify cases and determine the cause of the outbreak. A case was defined as any resident of Chitima who developed any new or unexplained neurologic, gastrointestinal, or cardiovascular symptom from January 9 at 6:00 a.m. through January 12. We conducted medical record reviews; healthcare worker and community surveys; anthropological and toxicological investigations of local medicinal plants and commercial pesticides; and laboratory testing of the suspect and control pombe...
November 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29154521/cryptosporidiosis-outbreak-associated-with-a-single-hotel
#2
Mary-Margaret A Fill, Jennifer Lloyd, Tamal Chakraverty, David Sweat, Judy Manners, Katie Garman, Michele C Hlavsa, Dawn M Roellig, John R Dunn, William Schaffner, Timothy F Jones
We investigated a gastrointestinal illness cluster among persons who attended a baseball tournament (>200 teams) during July 2015. We interviewed representatives of 19 teams; illness was reported among only the 9 (47%) teams that stayed at Hotel A (p < .01). We identified 55 primary cases. A case-control study demonstrated that pool exposure at Hotel A was significantly associated with illness (odds ratio: 7.3; 95% confidence interval: 3.6, 15.2). Eight out of nine (89%) stool specimens tested were positive for Cryptosporidium, with C...
May 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29150304/are-the-estrogenic-hormonal-effects-of-environmental-toxins-affecting-small-intestinal-bacterial-and-microfilaria-overgrowth
#3
Edward Lichten
The important role of microfilaria (worms) in human and animal disease remains an area of key disagreement between the naturopathic and allopathic physicians. While microfilaria infections are rampart in undeveloped countries, they rarely rise to identification as a cause of disease in Western countries. New research studies in the diagnosis and treatment of SIBO (Small Intestinal Bacterial Overgrowth) and (IBD) Inflammatory Bowel Diseases of ulcerative colitis, Crohn's Disease and microcytic colitis may make both sides equally correct...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29147653/health-status-and-the-demand-for-healthcare-among-the-elderly-in-the-rural-quoc-oai-district-of-hanoi-in-vietnam
#4
Kyung-Sook Bang, Sunghee H Tak, Juhwan Oh, Jinseon Yi, Soo-Young Yu, Truong Quang Trung
Background: Vietnam is experiencing an unprecedented demographic transition. Its proportion of elderly people is growing rapidly. Objective: This study explored the health status and health-related quality of life (HRQoL) of rural elderly Vietnamese and assessed their needs for healthcare services. Design: This study used a survey with stratified proportion sampling and quota assignment. In 2016, data was collected from 713 people in the rural Quoc-Oai district of Hanoi aged 60 or older...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29143891/in-search-of-the-ideal-promotility-agent-optimal-use-of-currently-available-promotility-agents-for-nutrition-therapy-of-the-critically-ill-patient
#5
REVIEW
Sarah J Diamond, Endashaw Omer, Laszlo Kiraly
PURPOSE OF REVIEW: Enteral nutrition therapy is essential in the management of critically ill patients. Prokinetic agents have been used successfully to aid in the delivery of nutrition and improve feeding tolerance in patients in the intensive care unit (ICU). The aim of this report is to review the existing promotility agents available for use in the critically ill as well as outline the role of potential investigative drugs in order to provide a guide to the management of this difficult and important clinical dilemma...
November 16, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29142080/human-parechovirus-an-increasingly-recognized-cause-of-sepsis-like-illness-in-young-infants
#6
REVIEW
Laudi Olijve, Lance Jennings, Tony Walls
Human parechovirus (HPeV) is increasingly being recognized as a potentially severe viral infection in neonates and young infants. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. HPeV-1 is the most prevalent genotype and most commonly causes gastrointestinal and respiratory disease. HPeV-3 is clinically the most important genotype due to its association with severe disease in younger infants, which may partly be explained by its distinct virological properties. In young infants, the typical clinical presentation includes fever, severe irritability, and rash, often leading to descriptions of "hot, red, angry babies...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29141526/the-in-pancia-study-clinical-evaluation-of-gastrointestinal-dysfunction-and-failure-multiple-organ-failure-and-levels-of-citrulline-in-critically-ill-patients
#7
Nazzareno Fagoni, Simone Piva, Rosella Marino, Giovanni Chiarini, Daniela Ferrari, Eleonora Grespi, Rita Bertuetti, Silvia Barbieri, Nicola Latronico, Frank Rasulo
PURPOSE: Gastrointestinal dysfunction and failure (GID and GIF) in critically ill patients are a common, relevant, and underestimated complications in ICU patients. The aims of this study were (1) to determine plasmatic levels of citrulline, glutamine, and arginine as markers of GID/GIF in critically ill patients with or without GID/GIF with or without multiple organ failure (MOF) and (2) to assess the role of intra-abdominal hypertension in these patient groups. MATERIALS AND METHODS: This is a 1-year, monocentric (Italian hospital), prospective observational study...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29141376/-clinical-significance-of-acute-gastrointestinal-injury-grades-in-inflammatory-response-of-critically-ill-patients
#8
J Wang, Y L Gao, W W Yu, Y H Xia, Y Z Sun
Objective: To explore the value of acute gastrointestinal injury (AGI) grades in inflammatory response of critically ill patients. Methods: Ptients with AGI severity from Ⅰ to Ⅳ were randomly selected(20 for each)from July 2014 to June 2015 in ICU of Yantai Yuhuangding Hospital. The expression of NF-κB were detected by immunofluorescence. The expression of TNF-α and IL-6 were detected by enzyme linked immunosorbent assay (ELISA). Procalcitonin (PCT) and C reactive protein (CRP) were measured. Statistical analysis was carried out...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138194/the-costs-of-functional-gastrointestinal-disorders-and-related-signs-and-symptoms-in-infants-a-systematic-literature-review-and-cost-calculation-for-england
#9
James Mahon, Carlos Lifschitz, Thomas Ludwig, Nikhil Thapar, Julie Glanville, Mohamad Miqdady, Miguel Saps, Seng Hock Quak, Irene Lenoir Wijnkoop, Mary Edwards, Hannah Wood, Hania Szajewska
OBJECTIVES: To estimate the cost of functional gastrointestinal disorders (FGIDs) and related signs and symptoms in infants to the third party payer and to parents. STUDY DESIGN: To estimate the cost of illness (COI) of infant FGIDs, a two-stage process was applied: a systematic literature review and a COI calculation. As no pertinent papers were found in the systematic literature review, a 'de novo' analysis was performed. For the latter, the potential costs for the third party payer (the National Health Service (NHS) in England) and for parents/carers for the treatment of FGIDs in infants were calculated, by using publicly available data...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137032/non-hodgkin-lymphoma-of-multiple-extranodal-involvement-seen-on-mri-fdg-pet-ct-scans-a-case-report
#10
Shan Wang, Meng Meng, Qiuhu Wang, Kai Xu
RATIONALE: Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the whole body skeletal muscles, with the aim to share the imaging features of the ALCL including magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134359/anxiety-depression-and-the-microbiome-a-role-for-gut-peptides
#11
REVIEW
Gilliard Lach, Harriet Schellekens, Timothy G Dinan, John F Cryan
The complex bidirectional communication between the gut and the brain is finely orchestrated by different systems, including the endocrine, immune, autonomic, and enteric nervous systems. Moreover, increasing evidence supports the role of the microbiome and microbiota-derived molecules in regulating such interactions; however, the mechanisms underpinning such effects are only beginning to be resolved. Microbiota-gut peptide interactions are poised to be of great significance in the regulation of gut-brain signaling...
November 13, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29132794/saccharomyces-cerevisiae-fungemia-after-probiotic-treatment-in-an-intensive-care-unit-patient
#12
I Kara, F Yıldırım, Ö Özgen, S Erganiş, M Aydoğdu, M Dizbay, G Gürsel, A Kalkanci
Saccharomyces cerevisiae is a common colonizer of the human gastrointestinal system as a benign organism. Enteral supplementation of this yeast as a probiotic product is effective in the treatment of antibiotic associated diarrhae. In rare occasions it can cause invasive infections. We present two fungemia cases in an intensive care unit following probiotic treatment containing S. boulardii. We are warning the safety of probiotic treatment in critically ill patients.
November 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29132517/surgical-critical-care-gastrointestinal-complications
#13
REVIEW
Rowan Sheldon, Matthew Eckert
Critical illness and injury affect the gastrointestinal tract almost uniformly. Complications include the sequelae of direct intestinal injury and repair, impaired motility, intra-abdominal hypertension, and ulceration, among others. Contemporary clinical practice has incorporated many advances in the prevention and treatment of gastrointestinal complications during critical illness. This article discusses the epidemiology, risk factors, means of diagnosis, treatment, and prevention of some of these compilations...
December 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29132246/phage-derived-protein-mediated-targeted-chemotherapy-of-pancreatic-cancer
#14
Tao Wang, Radhika Narayanaswamy, Huilan Ren, James W Gillespie, Valery A Petrenko, Vladimir P Torchilin
Pancreatic cancer has been a life-threatening illness associated with high incidence and mortality rates. Paclitaxel that causes mitotic arrest in cancer cells disrupting microtubule function is used for pancreatic cancer treatment[1]. Nausea, anorexia and abdominal pain are some of the typical dose-limiting toxicity associated gastrointestinal side effects of the drug[2]. Here we present the use of polymeric mixed micelles to enable a targeted delivery of Paclitaxel and to provide additional advantages such as enhanced drug solubility, bioavailability and minimal dose-limiting toxicity...
November 13, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29123834/inhaled-hydrogen-ameliorates-endotoxin-induced-bowel-dysfunction
#15
Hiroyuki Sakata, Ayana Okamoto, Michiko Aoyama-Ishikawa, Hayato Yamashita, Keisuke Kohama, Noritomo Fujisaki, Taihei Yamada, Joji Kotani, Kohei Tsukahara, Atsuyoshi Iida, Atsunori Nakao
Aim: Gastrointestinal dysmotility frequently occurs during sepsis and multiple organ failure, remaining a major cause of morbidity and mortality in critically ill patients. Previous studies have shown that hydrogen, a new therapeutic gas, can improve various organ damage associated with sepsis. In this study, we investigated the protective efficacies of inhaled hydrogen against lipopolysaccharide (LPS)-induced ileus. Methods: Sepsis was induced in rats and mice by a single i...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29118868/efficacy-of-video-capsule-endoscopy-in-the-management-of-suspected-small-bowel-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#16
Thomas A Zikos, Jennifer Pan, Berkeley Limketkai, Dipanjan Banerjee, Nielsen Fernandez-Becker
Background: Continuous flow left ventricular assist device (CF-LVAD) patients have a high prevalence of gastrointestinal bleeding from the small bowel. Video capsule endoscopy (VCE) is often used for diagnosis in these patients, but efficacy has yet to be determined. In this study, we evaluated the efficacy of VCE in the management of CF-LVAD patients with suspected small bowel bleeding by comparing to a non-VCE CF-LVAD control group. Methods: We retrospectively reviewed the charts of all patients with CF-LVADs implanted at Stanford Hospital from January 2010 to October 2015...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29114142/gastrointestinal-parasitic-infections-in-indian-gaddi-goat-breed-bucks-clinical-hemato-biochemical-parasitological-and-chemotherapeutic-studies
#17
Aman Dev Moudgil, Ankur Sharma, Madan Singh Verma, Ravindra Kumar, Pradeep Kumar Dogra, Pallavi Moudgil
The present study was envisaged with an aim to evaluate gastrointestinal parasitic infections in a herd of conserved Gaddi (goat) breed bucks (6-9 months of age) kept on semi-intensive feeding management. The individuals (n = 20) representing the herd were selected and divided into two groups; group I (n = 10), clinically ill and group II (n = 10), sub clinically infected individuals. The clinical examination revealed anemia, emaciation and rise in body temperature of the individuals of group I as compared to group II...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29107449/risk-of-gastrointestinal-hypomotility-in-schizophrenia-and-schizoaffective-disorder-treated-with-antipsychotics-a-retrospective-cohort-study
#18
Hsing-Kang Chen, Chia-Jung Hsieh
OBJECTIVE: The risk of gastrointestinal hypomotility (GIHM) with the use of antipsychotic medications in patients with schizophrenia remains inadequately recognized. The aim of this study was to explore the incidence of GIHM and its risks in patients with schizophrenia treated with antipsychotics. METHODS: We conducted a retrospective cohort study using the National Health Insurance Research Database. We identified adult (≥ 20years of age) patients with a first-time diagnosis of schizophrenia or schizoaffective disorder in the Registry for Catastrophic Illness Patients during the period from 2001 to 2011...
October 27, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29099778/upper-gastrointestinal-bleeding-in-children-a-tertiary-united-kingdom-children-s-hospital-experience
#19
Omar Nasher, David Devadason, Richard J Stewart
The aim of this study was to review the aetiology, presentation and management of these patients with upper gastrointestinal bleeding (UGIB) at a tertiary children's unit in the United Kingdom. This was a retrospective single-institution study on children (<16 years) who presented with acute UGIB over a period of 5 years using known International Classification of Diseases (ICD) codes. A total of 32 children (17 males, 15 females) were identified with a total median age at presentation of 5.5 years. The majority (24/32) of patients presented as an emergency...
November 3, 2017: Children
https://www.readbyqxmd.com/read/29098118/gut-microbiota-and-salivary-diagnostics-the-mouth-is-salivating-to-tell-us-something
#20
REVIEW
Krishna Kodukula, Douglas V Faller, David N Harpp, Iphigenia Kanara, Julie Pernokas, Mark Pernokas, Whitney R Powers, Nikolaos S Soukos, Kosta Steliou, Walter H Moos
The microbiome of the human body represents a symbiosis of microbial networks spanning multiple organ systems. Bacteria predominantly represent the diversity of human microbiota, but not to be forgotten are fungi, viruses, and protists. Mounting evidence points to the fact that the "microbial signature" is host-specific and relatively stable over time. As our understanding of the human microbiome and its relationship to the health of the host increases, it is becoming clear that many and perhaps most chronic conditions have a microbial involvement...
2017: BioResearch Open Access
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