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https://www.readbyqxmd.com/read/28537938/should-all-massively-transfused-patients-be-treated-equally-an-analysis-of-massive-transfusion-ratios-in-the-nontrauma-setting
#1
Eric W Etchill, Sara P Myers, Lauren M McDaniel, Matthew R Rosengart, Jay S Raval, Darrell J Triulzi, Andrew B Peitzman, Jason L Sperry, Matthew D Neal
OBJECTIVES: Although balanced resuscitation has become integrated into massive transfusion practice, there is a paucity of evidence supporting the delivery of high ratios of plasma and platelet to RBCs in the nontrauma setting. This study investigated the administration of blood component ratios in the massively transfused nontrauma demographic. DESIGN: Retrospective analysis of a prospective, observational cohort of massively bleeding patients. SETTING: Surgical and critically ill patients at a tertiary medical center between 2011 and 2015...
May 23, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28533998/ipilimumab-as-a-cause-of-severe-pan-colitis-and-colonic-perforation
#2
Raj Shah, Danielle Witt, Talal Asif, Fahad F Mir
Ipilimumab is a human monoclonal antibody that functions as a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor that is used to treat malignant melanoma. Due to ipilimumab's removal of immune regulation, specifically through the inactivation of CTLA-4, it is commonly associated with inflammatory and autoimmune events. Gastrointestinal (GI) related immune-related adverse events such as diarrhea occur in 29% of patients with 7.6% of patients specifically suffering from colitis. We describe a case of colonic perforation with ipilimumab use...
April 20, 2017: Curēus
https://www.readbyqxmd.com/read/28533916/pediatric-intensive-care-stress-ulcer-prevention-pic-up-a-protocol-for-a-pilot-randomized-trial
#3
Mark Duffett, Karen Choong, Jennifer Foster, Elaine Gilfoyle, Jacques Lacroix, Nikhil Pai, Lehana Thabane, Deborah J Cook
BACKGROUND: Despite sparse pediatric data on effectiveness, the majority of critically ill children receive medications to prevent gastrointestinal (GI) bleeding. Stress ulcer prophylaxis may have unintended consequences-increasing the risk of nosocomial infections-which may be more serious and common than the bleeding which these drugs are prescribed to prevent. Randomized controlled trials (RCTs) in pediatric critical care are exceptionally challenging to complete, thus a rigorous pilot RCT is crucial...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28520707/using-molecular-characterization-to-support-investigations-of-aquatic-facility-associated-outbreaks-of-cryptosporidiosis-alabama-arizona-and-ohio-2016
#4
Michele C Hlavsa, Dawn M Roellig, Matthew H Seabolt, Amy M Kahler, Jennifer L Murphy, Taishayla K McKitt, Evelyn F Geeter, Ron Dawsey, Sherri L Davidson, Thuy N Kim, Theresa H Tucker, Sally Ann Iverson, Brenna Garrett, Nicole Fowle, Jennifer Collins, Gregory Epperson, Scott Zusy, Joli R Weiss, Ken Komatsu, Edwin Rodriguez, J Gage Patterson, Rebecca Sunenshine, Brandi Taylor, Katie Cibulskas, Lynn Denny, Keoni Omura, Boris Tsorin, Kathleen E Fullerton, Lihua Xiao
Cryptosporidiosis is a nationally notifiable gastrointestinal illness caused by parasitic protozoa of the genus Cryptosporidium, which can cause profuse, watery diarrhea that can last up to 2-3 weeks in immunocompetent patients and can lead to life-threatening wasting and malabsorption in immunocompromised patients. Fecal-oral transmission of Cryptosporidium oocysts, the parasite's infectious life stage, occurs via ingestion of contaminated recreational water, drinking water, or food, or following contact with infected persons or animals, particularly preweaned bovine calves (1)...
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28515790/comparative-genomic-analysis-reveals-genetic-features-related-to-the-virulence-of-bacillus-cereus-forc_013
#5
Hyun-Jin Koo, Sojin Ahn, Han Young Chung, Suyeon Kim, Kwondo Kim, Sangryeol Ryu, Ju-Hoon Lee, Sang Ho Choi, Heebal Kim
BACKGROUND: Bacillus cereus is well known as a gastrointestinal pathogen that causes food-borne illness. In the present study, we sequenced the complete genome of B. cereus FORC_013 isolated from fried eel in South Korea. To extend our understanding of the genomic characteristics of FORC_013, we conducted a comparative analysis with the published genomes of other B. cereus strains. RESULTS: We fully assembled the single circular chromosome (5,418,913 bp) and one plasmid (259,749 bp); 5511 open reading frames (ORFs) and 283 ORFs were predicted for the chromosome and plasmid, respectively...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28515291/differential-disease-susceptibility-in-experimentally-reptarenavirus-infected-boa-constrictors-and-ball-pythons
#6
Mark D Stenglein, David Sanchez-Migallon Guzman, Valentina E Garcia, Marylee L Layton, Laura L Hoon-Hanks, Scott M Boback, M Kevin Keel, Tracy Drazenovich, Michelle G Hawkins, Joseph L DeRisi
Inclusion body disease (IBD) is an infectious disease originally described in captive snakes. It has traditionally been diagnosed by the presence of large eosinophilic cytoplasmic inclusions, and is associated with neurological, gastrointestinal and lymphoproliferative disorders. Previously, we identified and established a culture system for a novel lineage of arenaviruses isolated from boa constrictors diagnosed with IBD. Although ample circumstantial evidence suggested that these viruses, now known as reptarenaviruses, cause IBD, there has been no formal demonstration of disease causality since their discovery...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513822/abdominal-pressure-and-gastrointestinal-function-an-inseparable-couple
#7
Annika Reintam Blaser, Manu Lng Malbrain, Adrian Regli
Evaluating the degree of organ dysfunction is a cornerstone in distinguishing patients with critical illness from those without. However, evaluation of the gastrointestinal (GI) function in critically ill patients is not unified, and is still largely based on subjective clinical evaluation. Intra-abdominal pressure (IAP) has been proposed as a parameter to facilitate monitoring of abdominal compartment in critical illness, but the interactions between IAP and GI function are poorly clarified.The aim of this current review is to describe interactions and associations between GI dysfunction and IAP from a pathophysiological and clinical point of view...
May 17, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28511732/outbreak-of-diarrhoea-among-participants-of-a-triathlon-and-a-duathlon-on-12-july-2015-in-utrecht-the-netherlands
#8
S Parkkali, R Joosten, E Fanoy, R Pijnacker, J VAN Beek, D Brandwagt, W VAN Pelt
On 12 July 2015, a triathlon competition with 900 participants took place in Utrecht, the Netherlands. An outbreak investigation was initiated after 56 participants reported health complaints. An online questionnaire was sent to 700 participants. Stool specimens from six participants and four water specimens were collected from the swimming location. A total of 239 participants completed the questionnaire (response rate: 34%), 73 (31%) of them met the case definition for acute gastrointestinal illness (AGI)...
May 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28509764/environmental-and-physiological-factors-affect-football-head-impact-biomechanics
#9
Jason P Mihalik, Adam Z Sumrall, Susan W Yeargin, Kevin M Guskiewicz, Kevin B King, Scott C Trulock, Edgar W Shields
PURPOSE: Recent anecdotal trends suggest a disproportionate number of head injuries in collegiate football players occur during preseason football camp. In warmer climates, this season also represents the highest risk for heat-related illness among collegiate football players. Since concussion and heat illnesses share many common symptoms, we need 1) to understand if environmental conditions, body temperature, and hydration status affect head impact biomechanics; and 2) to determine if an in-helmet thermistor could provide a valid measure of gastrointestinal temperature...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28507906/a-case-of-a-positive-coccidioides-stool-culture-in-an-immunocompetent-patient-with-disseminated-coccidioidomycosis
#10
Majd Alfreijat, Brian Wilhelmi
Coccidioidomycosis (CM) is an infection caused by the coccidioides fungus. The spectrum of the disease ranges from a mild upper respiratory illness to severe disseminated infection that could affects the bones, joints, skin, central nervous system, and the gastrointestinal tract. Previous reports of a positive stool culture in the setting of disseminated CM are extremely rare. Herein, we describe a case of a 43-year-old immunocompetent patient with disseminated CM and evidence of positive coccidioides stool culture...
2017: IDCases
https://www.readbyqxmd.com/read/28507260/reprogramming-cells-from-gulf-war-veterans-into-neurons-to-study-gulf-war-illness
#11
Liang Qiang, Anand N Rao, Gustavo Mostoslavsky, Marianne F James, Nicole Comfort, Kimberly Sullivan, Peter W Baas
Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990-1991 war in the Persian Gulf, is thought to be caused by deployment exposures to various neurotoxicants, including pesticides, anti-nerve gas pills, and low-level nerve agents including sarin/cyclosarin. GWI is a multisymptom disorder characterized by fatigue, joint pain, cognitive problems, and gastrointestinal complaints. The most prominent symptoms of GWI (memory problems, poor attention/concentration, chronic headaches, mood alterations, and impaired sleep) suggest that the disease primarily affects the CNS...
May 16, 2017: Neurology
https://www.readbyqxmd.com/read/28505469/the-association-between-immune-markers-and-recent-suicide-attempts-in-patients-with-serious-mental-illness-a-pilot-study
#12
Faith Dickerson, Maria Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina Savage, Lucy Schweinfurth, Cassie Stallings, Kevin Sweeney, Armin Alaedini, Melanie Uhde, Emily Severance, Holly C Wilcox, Robert Yolken
Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP)...
May 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28502447/the-transition-of-the-gastrointestinal-patient-from-pediatric-to-adult-care
#13
REVIEW
Punyanganie S A de Silva, Laurie N Fishman
Transition is the long process of developing independent self-management skills whereas transfer is the actual move from pediatric to adult-centered provider. Structured anticipated transition works best with timelines of tasks to master and discussion of the stylistic differences between pediatric and adult practices. Disease-specific issues need to be addressed, such as earlier timelines for diet-based therapies, parental support for critical illnesses, and differences in therapeutic strategies.
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28498895/acute-illness-among-surfers-after-exposure-to-seawater-in-dry-and-wet-weather-conditions
#14
Benjamin F Arnold, Kenneth C Schiff, Ayse Ercumen, Jade Benjamin-Chung, Joshua A Steele, John F Griffith, Steven J Steinberg, Paul Smith, Charles D McGee, Richard Wilson, Chad Nelsen, Stephen B Weisberg, John M Colford
Rainstorms increase levels of fecal indicator bacteria in urban coastal waters, but it is unknown whether exposure to seawater after rainstorms increases rates of acute illness. Our objective was to provide the first estimates of rates of acute illness after seawater exposure during both dry- and wet-weather periods and to determine the relationship between levels of indicator bacteria and illness among surfers, a population with a high potential for exposure after rain. We enrolled 654 surfers in San Diego, California, and followed them longitudinally during the 2013-2014 and 2014-2015 winters (33,377 days of observation, 10,081 surf sessions)...
May 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28498220/patient-presentations-and-medical-logistics-at-full-and-half-ironman-distance-triathlons
#15
Sheila A Turris, Adam Lund, Ron R Bowles, Michael Camporese, Tom Green
We describe logistical challenges, illness/injury rates, as well as medical and ambulance transfer rates (ATR) at an annual large-scale half/full triathlon in a remote location. Prospective observational study; registry data. Data on patient presentation rates, percentage of patients transferred by ambulance, transfer to hospital rates (TTHR), ATR, and medical usage rates were collected and analyzed. In total, 1923 athletes participated in the 2016 triathlon (1404 in the full-length race and 519 in the half) and 181 patient encounters were documented...
May 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28496350/intravenous-citrulline-generation-test-to-assess-intestinal-function-in-intensive-care-unit-patients
#16
Job Hc Peters, Nicolette J Wierdsma, Albertus Beishuizen, Tom Teerlink, Ad A van Bodegraven
BACKGROUND: Assessment of a quantifiable small intestinal function test is cumbersome. Fasting citrulline concentrations have been proposed as a measure of enterocyte function and elaborated into a citrulline generation test (CGT), which is applicable only when glutamine is administered orally. CGT is an oral test, limiting its use, for example, in critically ill patients. OBJECTIVE: Assessment of normative values and feasibility of an intravenously performed CGT in intensive care unit (ICU) patients with presumed gastrointestinal motility disturbances, especially when performed intravenously...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28490564/association-between-serum-osmolarity-and-mortality-in-patients-who-are-critically-ill-a-retrospective-cohort-study
#17
Yanfei Shen, Xuping Cheng, Manzhen Ying, Hao-Tang Chang, Weimin Zhang
OBJECTIVES: This research aims to explore the association between serum osmolarity and mortality in patients who are critically ill with specific categories of disease. DESIGN: A retrospective cohort study. SETTING AND PARTICIPANTS: Data were extracted from an online database named 'Multiparameter Intelligent Monitoring in Intensive Care II'. 16 598 patients were included. METHODS: Patients were divided into six disease subgroups based on the diagnosis at admission: cardiac, cerebral, vascular, gastrointestinal, respiratory and non-respiratory...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28489717/coliphages-and-gastrointestinal-illness-in-recreational-waters-pooled-analysis-of-six-coastal-beach-cohorts
#18
Jade Benjamin-Chung, Benjamin F Arnold, Timothy J Wade, Kenneth Schiff, John F Griffith, Alfred P Dufour, Stephen B Weisberg, John M Colford
BACKGROUND: Coliphages have been proposed as indicators of fecal contamination in recreational waters because they better mimic the persistence of pathogenic viruses in the environment and wastewater treatment than fecal indicator bacteria. We estimated the association between coliphages and gastrointestinal illness and compared it to the association with culturable enterococci. METHODS: We pooled data from six prospective cohort studies that enrolled coastal beachgoers in California, Alabama, and Rhode Island...
May 9, 2017: Epidemiology
https://www.readbyqxmd.com/read/28488835/incidence-of-injury-and-illness-in-south-african-professional-male-football-players-a-prospective-cohort-study
#19
Helen Bayne, Martin Schwellnus, Dina Janse Van Rensburg, Jhano Botha, Lervasen Pillay
BACKGROUND: Medical illnesses and sports-related injuries both have an effect on athlete health and performance. Epidemiology of injury and illness has been extensively researched during international football tournaments and the European football season. Reports on injury location and severity differ across geographical regions, and there is limited information on injury epidemiology in African football leagues. No studies have investigated the illness burden in football in Africa. METHODS: This was a prospective cohort study involving two football teams over the 10- month duration of the 2015/16 Premier Soccer League in South Africa...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28482432/-quick-confirmation-of-nasointestinal-tube-placed-below-pylorus-in-critically-ill-patients-by-duodenal-bulb-ultrasonic-anatomy-locating-method
#20
R Z Ye, X M Fan, R H Sun, F Zhang, L G Wang, Z Zeng, Y Liu, B C Hu, Y X Tu
Objective: To investigate the value of duodenal bulb ultrasonic anatomy locating method quickly confirm nasointestinal tube placed below pylorus in critically ill patients. Methods: A total of 56 critically ill patients with nasointestinal tube posting surgery by blindly inserting method were collected from March 1 st, 2016 to August 1 st, 2016 in the Department of Critical Care Medicine of Zhejiang Provincial People's Hospital.In these patients, the duodenal bulbs were rapidly detected and located by ultrasonic anatomy locating method and at the same time observed whether nasointestinal tube echogram were in them or not...
May 9, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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