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insuline at hone

Martin de Kort, Bas Gianotten, Jeffry A J Wisse, Ebo S Bos, Michel H M Eppink, Ellen Mattaar, Gerard M T Vogel, Wim H A Dokter, Maarten Honing, Stanislava Vonsovic, Martin-Jan Smit, Jac C H M Wijkmans, Constant A A van Boeckel
No abstract text is available yet for this article.
August 2008: ChemMedChem
Anthony P Furnary, David B Cheek, Steven C Holmes, W Lyall Howell, Stephen P Kelly
Intensive insulin therapy to control perioperative hyperglycemia has become the new standard of care for cardiac surgery patients. Although there are several published protocols for achieving tight glycemic control in the postoperative period, there are no such published protocols or even suggested methods for intraoperative control. At Providence St. Vincent Hospital in Portland, Oregon, we have been using postoperative insulin infusions under study protocol since 1992 and have been using intravenous insulin to control intraoperative glucose levels since 1995...
2006: Seminars in Thoracic and Cardiovascular Surgery
S Grimme, S Höning, K von Figura, B Schmidt
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF-II receptor) plays an important role in controlling the extracellular level of the insulin-like growth factor II (IGF-II) by mediating its binding at the cell surface and delivery to lysosomes. Loss of the receptor is associated with an accumulation of IGF-II, which can cause perinatal lethality if it is systemic, or local proliferation and tumorgenesis if it is spatially restricted. The extracytoplasmic domain of the receptor consists of 15 homologous repeats, of which repeat 11 carries the IGF-II-binding site of the multifunctional receptor...
October 27, 2000: Journal of Biological Chemistry
L Ständker, T Braulke, S Mark, H Mostafavi, M Meyer, S Höning, G Giménez-Gallego, W G Forssmann
Within the IGF axis, the insulin-like growth factor-binding proteins (IGFBPs) are known to play a pivotal role in cell proliferation and differentiation. Defined proteolysis of the IGFBPs is proposed to be an essential mechanism for regulating IGF bioavailability. The generated IGFBP fragments in part exhibit different IGF-dependent and -independent biological activities. Characterizing naturally occurring forms of IGFBPs in human plasma, we identified both a N- and a C-terminal fragment of IGFBP-4 by means of immunoreactivity screening...
May 2, 2000: Biochemistry
S I Taylor, D Accili, C R Haft, J Hone, Y Imai, R Levy-Toledano, M J Quon, Y Suzuki, E Wertheimer
Hormones are secreted by endocrine glands and transported to the target cell at which the hormone acts. The hormone binds to its receptor, thereby eliciting various biological responses within the target cell. Examples of disease mechanisms that function at the different stages in the development of the insulin receptor, and result in insulin resistance, are discussed in this review. Antibodies to insulin can impair delivery of the hormone to the target cell, and can desensitize that target cell to insulin action...
April 1994: Acta Paediatrica. Supplement
J Hone, D Accili, L I al-Gazali, G Lestringant, T Orban, S I Taylor
Mutations in the insulin receptor gene can cause genetic syndromes such as leprechaunism that are associated with extreme insulin resistance. We have investigated a patient with leprechaunism born of a consanguineous marriage. All 22 exons of the insulin receptor gene were screened for mutations using denaturing gradient gel electrophoresis. Thereafter, the nucleotide sequences of selected exons were determined directly. The patient was homozygous for a point mutation in exon 2 of the insulin receptor gene which results in the substitution of methionine for isoleucine at codon 119...
September 1994: Journal of Medical Genetics
J Hone, D Accili, H Psiachou, J Alghband-Zadeh, S Mitton, E Wertheimer, L Sinclair, S I Taylor
Mutations in the insulin receptor gene can cause genetic syndromes associated with extreme insulin resistance. We have investigated a patient with leprechaunism (leprechaun/Qatar-1) born of a consanguineous marriage. Postnatally, the proband had episodes of severe hypoglycemia and hyperinsulinernia, with blood glucose levels ranging from 0.9 to 9.9 mmol/L. The C peptide concentration with 1880 nmol/L, and the total insulin concentration was 1409 mU/L. The patient died outside the hospital at the age of four months...
1995: Human Mutation
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