Chen Chen, Guan-Zhi Liu, Yue-Yuan Liao, Chao Chu, Wen-Ling Zheng, Yang Wang, Jia-Wen Hu, Qiong Ma, Ke-Ke Wang, Yu Yan, Yue Yuan, Jian-Jun Mu
In the current study, we aimed to identify potential biomarkers for salt sensitivity of blood pressure (SSBP), which may provide a novel insight into the pathogenic mechanisms of salt-sensitive hypertension. Firstly, we conducted weighted gene coexpression network analysis (WGCNA) and selected a gene module and 60 hub genes significantly correlated to SSBP. Then, GO function and KEGG signaling pathway enrichment analysis and protein-protein interaction (PPI) network analysis were performed. Furthermore, we identified a five-gene signature with high connectivity degree in the PPI network and high AUC of ROC curves, which may have high diagnosis value for SSBP...
2020: Frontiers in Genetics