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KAT G tuberculosis

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https://www.readbyqxmd.com/read/23677159/-mycobacterium-tuberculosis-infection-in-a-pediatric-patient-who-underwent-a-hematopoietic-stem-cell-transplant
#1
Julia Palma, Paula Catalán, Patricia Mardones, M Elena Santolaya
We report the case of a 10 year old girl with a relapsed acute lymphoblastic leukemia, who underwent a haploidentical hematopoietic stem cell transplant (HSCT), with grade II skin and digestive graft versus host disease, treated with corticosteroids and cyclosporine. On day + 54, she presented fever, with no other remarkable clinical findings. Imaging study showed the presence of lung and liver nodules, liver biopsy was performed. The study included histology, staining and culture for bacteria and fungi, and the preservation of a piece of tissue at -20°C for future prospective studies...
April 2013: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/22118179/molecular-characterisation-of-isoniazid-and-rifampicin-resistant-mycobacterium-tuberculosis-in-central-tunisia
#2
I Ben Kahla, M Marzouk, M Henry, M Bedotto, S Cohen-Bacrie, W Ben Selma, J Boukadida, M Drancourt
The aim of our study was to genotypically characterise isoniazid (INH) and rifampicin (RMP) resistant Mycobacterium tuberculosis isolates in Sousse, Central Tunisia, using DNA sequencing and multispacer sequence typing (MST). The results show that 27/28 (96.4%) and 1/28 (3.6%) INH-resistant isolates yielded respectively the kat G S315T and the inh A - 15C → T mutations. Two-thirds of RMP-resistant isolates yielded the rpo B D516V mutation and one sixth yielded either H526D or S531L mutations. Genotyping analysis revealed the multiclonal spread of drug-resistant isolates in Central Tunisia...
December 2011: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/19183459/genotypic-detection-of-rifampicin-and-isoniazid-resistant-mycobacterium-tuberculosis-strains-by-dna-sequencing-a-randomized-trial
#3
COMPARATIVE STUDY
Amina Abdelaal, Hassan Abd El-Ghaffar, Mohammad Hosam Eldeen Zaghloul, Noha El Mashad, Ehab Badran, Amal Fathy
BACKGROUND: Tuberculosis is a growing international health concern. It is the biggest killer among the infectious diseases in the world today. Early detection of drug resistance allows starting of an appropriate treatment. Resistance to drugs is due to particular genomic mutations in specific genes of Mycobacterium tuberculosis(MTB). The aim of this study was to identify the presence of Isoniazid (INH) and Rifampicin(RIF) drug resistance in new and previously treated tuberculosis (TB) cases using DNA sequencing...
2009: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/16872043/molecular-characterization-of-mutation-associated-with-rifampicin-and-isoniazid-resistance-in-mycobacterium-tuberculosis-isolates
#4
Sanjay Singh Negi, Ranjana Anand, S T Pasha, Sunil Gupta, Seemi Farhat Basir, Shashi Khare, Shiv Lal
Nucleotide changes in catalase peroxidase (Kat G) gene and gene encoding the beta subunit of RNA polymerase (rpo B), responsible for isoniazid and rifampicin drug resistance were determined in the clinical isolates of Mycobacterium tuberculosis by PCR-RFLP, Line probe assay and DNA sequencing. PCR-RFLP test was performed by HapII cleavage of an amplified fragment of Kat G gene to detect the transversion 315AGC-->ACC(Ser-->Thr) which is associated with INH drug resistance. The Line probe assay kit was evaluated to detect the mutation in 81bp RMP resistance determining region of rpo B gene associated with RMP drug resistance...
July 2006: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/14187776/-therapeutic-trials-of-a-new-injectable-antitussive-agent-kat-256
#5
G DUMON, M T BROUILLET-GABRIEL, G HEUILLET
No abstract text is available yet for this article.
October 3, 1964: La Presse Médicale
https://www.readbyqxmd.com/read/12099732/molecular-analysis-of-clinical-isolates-of-mycobacterium-tuberculosis-collected-from-patients-with-persistent-disease-in-the-khartoum-region-of-sudan
#6
G S Sharaf-Eldin, N S Saeed, M E Hamid, A M Jordaan, G D Van der Spuy, R M Warren, P D Van Helden, T C Victor
SETTING: Patients with positive smears for acid-fast bacilli were enrolled at tuberculosis (TB) clinics in the Khartoum region of Sudan. OBJECTIVE: To identify the presence of drug resistant genotypes in M. tuberculosis isolates which are difficult to treat. METHODS: Genus specific PCR-SSCP was performed to confirm the presence of M. tuberculosis in clinical isolates. Genotypic drug resistance testing was performed by mutation analysis and spoligotyping was used to monitor transmission and to identify epidemic strains...
May 2002: Journal of Infection
https://www.readbyqxmd.com/read/9830523/molecular-genetic-analysis-of-multi-drug-resistance-in-indian-isolates-of-mycobacterium-tuberculosis
#7
N Siddiqi, M Shamim, N K Jain, A Rattan, A Amin, V M Katoch, S K Sharma, S E Hasnain
A total of 116 isolates from patients attending the out-patient department at the All India Institute of Medical Sciences, New Delhi and the New Delhi Tuberculosis Centre, New Delhi, India were collected. They were analyzed for resistance to drugs prescribed in the treatment for tuberculosis. The drug resistance was initially determined by microbiological techniques. The Bactec 460TB system was employed to determine the type and level of resistance in each isolate. The isolates were further characterized at molecular level...
September 1998: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/9444026/kat-g-mutations-in-isoniazid-resistant-mycobacterium-tuberculosis-isolates-from-thai-patients
#8
S Paca-uccaralertkun, C Chuchottaworn
Isoniazid resistant mechanisms in Mycobacterium tuberculosis have been shown to involve at least two genes, kat G and inh A. Alteration in the kat G gene has been found in a great number of resistant isolates. Percentage of resistant isolates harboring alteration in this gene varied among laboratories suggesting that different mutations were presented in different geographic areas. Fourteen isoniazid resistant and five multidrug resistant isolates from the Central Chest Hospital, Thailand, were examined for the kat G gene mutations in the region between base position 17 to 299...
June 1997: Southeast Asian Journal of Tropical Medicine and Public Health
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