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idiopathic intracranial hypertension

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https://www.readbyqxmd.com/read/28806347/pediatric-pseudotumor-cerebri-syndrome
#1
Paul H Phillips, Claire A Sheldon
Idiopathic intracranial hypertension, otherwise known as primary pseudotumor cerebri syndrome (PTCS), most frequently occurs in obese women of childbearing age. However, children may be affected as well. This review will address recent findings regarding demographics, diagnosis, and treatment of pediatric PTCS. Prepubertal children with primary PTCS have an equal sex distribution and less frequent obesity compared with adult patients. However, female gender and obesity are risk factors for primary PTCS in postpubertal children...
September 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28800199/intracranial-elastance-is-increased-in-idiopathic-intracranial-hypertension
#2
Jason T Chisholm, Padmaja Sudhakar, Abdulnasser N Alhajeri, Jonathan H Smith
BACKGROUND: To date, no pathophysiologic model has sufficiently accounted for all the findings encountered in patients with idiopathic intracranial hypertension (IIH). Intracranial elastance is an index of volume-buffering capacity known to play a role in certain disorders of CSF dynamics, which has not been previously investigated in relation to IIH patients. METHODS: Single-center retrospective cohort study from July 1, 2011 to July 1, 2016. We collected values for opening pressure (PO ), closing pressure (PC ), volume (V) of CSF removed, as well as demographic and clinical covariates...
August 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28794092/optic-disc-swelling-in-a-patient-with-tuberculous-meningitis-a-diagnostic-challenge
#3
Hanis Zuhaimy, Sue Ngein Leow, Suresh K Vasudevan
We discuss the diagnostic challenge in an adult patient presented with purely ocular symptoms diagnosed with tuberculous meningitis (TBM). A 38-year-old woman presented with bilateral painless blurring of vision. There were bilateral sixth cranial nerve palsy and bilateral optic disc swelling. Optic nerve function tests were normal. Patient was lucid with no signs of meningism. Brain imaging were normal. She had a positive Mantoux test, high erythrocyte sedimentation rate but no clinical evidence of active pulmonary tuberculosis infection...
August 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28768582/blind-overnight-a-case-of-fulminant-idiopathic-intracranial-hypertension
#4
Janpreet Singh Bhandohal, Taimur Mirza
Idiopathic Intracranial Hypertension (IIH) is a syndrome seen predominantly in obese women of reproductive age group, characterized by signs and symptoms of increased intracranial pressure due to an unknown cause. Some individuals have a more malignant form of disease called fulminant idiopathic intracranial hypertension with rapid worsening of symptoms over days. We report a case of 33year-old obese female (BMI 36.9) who presented with a severe headache and blurred vision for one week, found to have idiopathic intracranial hypertension with rapid worsening of symptoms suggestive of a fulminant course of disease...
July 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28758206/the-idiopathic-intracranial-hypertension-treatment-trial-a-review-of-the-outcomes
#5
Stacy V Smith, Deborah I Friedman
OBJECTIVE: The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) was the first large, randomized study on the use of acetazolamide and weight loss for treatment of idiopathic intracranial hypertension-associated vision loss. The multicenter trial also examined a number of secondary outcomes. This review summarizes all available results of the study published in the literature since 2014. BACKGROUND: Prior to the IIHTT, clinicians managed idiopathic intracranial hypertension based on data from small, unmasked trials, expert opinion, and clinical experience...
July 30, 2017: Headache
https://www.readbyqxmd.com/read/28756599/long-term-monitoring-of-intracranial-pressure-in-normal-pressure-hydrocephalus-and-other-csf-disorders
#6
EDITORIAL
Zofia Czosnyka, Marek Czosnyka
Long-term monitoring of intracranial pressure is a useful method in the diagnosis of complex hydrocephalus and CSF disorders. This editorial discusses various criteria for the interpretation of ICP monitoring in normal pressure hydrocephalus, idiopathic intracranial hypertension and in patients with implanted hydrocephalus shunts.
July 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28752894/headache-in-idiopathic-intracranial-hypertension-findings-from-the-idiopathic-intracranial-hypertension-treatment-trial
#7
Deborah I Friedman, Peter A Quiros, Prem S Subramanian, Luis J Mejico, Shan Gao, Michael McDermott, Michael Wall
OBJECTIVE: To characterize the phenotype, headache-related disability, medical co-morbidities, use of symptomatic headache medications, and headache response to study interventions in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). METHODS: Patients with untreated IIH and mild vision loss enrolled in the IIHTT and randomized to acetazolamide (ACZ) and weight loss or placebo (PLB) and weight loss had prospective assessment of headache disability using the Headache Impact Test-6 (HIT-6) questionnaire...
July 28, 2017: Headache
https://www.readbyqxmd.com/read/28751968/lumboperitoneal-shunt-insertion-without-fluoroscopy-guidance-accuracy-of-placement-in-a-series-of-107-procedures
#8
Sabah Al-Rashed, Haider Kareem, Neeraj Kalra, Linda D'Antona, Mouness Obeidat, Bhavesh Patel, Ahmed Toma
Background: Lumboperitoneal (LP) shunts were the mainstay of cerebrospinal fluid diversion therapy for idiopathic intracranial hypertension (IIH). The traditionally cited advantage of LP shunts over ventriculoperitoneal (VP) shunts is the ease of insertion in IIH. This needs to be placed at the level of L3/4 to be below the level of the spinal cord. The objective of this study was to analyse the position of LP shunts inserted without portable fluoroscopy guidance.  Methods: A retrospective analysis of radiology was performed for patients who underwent lumboperitoneal shunts between 2006 and 2016 at the National Hospital for Neurology and Neurosurgery...
2017: F1000Research
https://www.readbyqxmd.com/read/28742639/idiopathic-intracranial-hypertension-progressing-to-venous-sinus-thrombosis-subarachnoid-hemorrhage-and-stroke
#9
Joshua S Hardin, Raghu H Ramakrishnaiah, John D Pemberton, Paul H Phillips, Joseph G Chacko
Idiopathic intracranial hypertension (IIH) is a syndrome characterized by increased intracranial pressure (ICP), the absence of structural lesions on neuroimaging, and normal cerebrospinal fluid composition. Cerebral venous sinus thrombosis (CVST) is a common cause of increased ICP and can be differentiated from IIH with magnetic resonance venography. We describe a young woman with typical IIH who underwent lumbar puncture and was treated with a short course of high-dose corticosteroids followed by acetazolamide...
July 24, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28735654/chronic-fatigue-syndrome-and-idiopathic-intracranial-hypertension-different-manifestations-of-the-same-disorder-of-intracranial-pressure
#10
J Nicholas P Higgins, John D Pickard, Andrew M L Lever
Though not discussed in the medical literature or considered in clinical practice, there are similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) which ought to encourage exploration of a link between them. The cardinal symptoms of each - fatigue and headache - are common in the other and their multiple other symptoms are frequently seen in both. The single discriminating factor is raised intracranial pressure, evidenced in IIH usually by the sign of papilloedema, regarded as responsible for the visual symptoms which can lead to blindness...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28733756/glial-and-neuronal-antibodies-in-patients-with-idiopathic-intracranial-hypertension
#11
Güneş Altıokka-Uzun, Ece Erdağ, Betül Baykan, John Tzartos, Duygu Gezen-Ak, Bedia Samancı, Erdinç Dursun, Paraskevi Zisimopoulou, Katerina Karagiorgou, Christos Stergiou, Erdi Şahin, Esme Ekizoğlu, Murat Kürtüncü, Erdem Tüzün
Headache and visual disturbances are the main presenting symptoms of idiopathic intracranial hypertension (IIH) characterized by increased intracranial pressure (ICP) with an unknown cause. We aimed to investigate the antibodies against optic neuritis-associated glial antigens, aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) and uncharacterized neuronal membrane antigens in IIH patients. Consecutive patients diagnosed according to Friedman revised diagnostic criteria and control subjects were included after their consent...
July 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28716667/pupillometric-evaluation-of-the-melanopsin-containing-retinal-ganglion-cells-in-mitochondrial-and-non-mitochondrial-optic-neuropathies
#12
Shakoor Ba-Ali, Henrik Lund-Andersen
In recent years, chromatic pupillometry is used in humans to evaluate the activity of melanopsin expressing intrinsic photosensitive retinal ganglion cells (ipRGCs). Blue light is used to stimulate the ipRGCs and red light activates the rod/cone photoreceptors. The late re-dilation phase of pupillary light reflex is primarily driven by the ipRGCs. Optic neuropathies i.e. Leber hereditary optic neuropathy (LHON), autosomal dominant optic atrophy (ADOA), nonarteritic anterior ischemic optic neuropathy (NAION), glaucoma, optic neuritis and idiopathic intracranial hypertension (IIH) are among the diseases, which have been subject to pupillometric studies...
July 14, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28711538/cerebral-venous-sinus-thrombosis-secondary-to-idiopathic-hypertrophic-cranial-pachymeningitis-a-case-report-and-review-of-the-literature
#13
Kaiyuan Huang, Qingsheng Xu, Yuankun Ma, Renya Zhan, Jian Shen, Jianwei Pan
BACKGOUND AND IMPORTANCE: Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare fibrosing inflammatory process involving the dura mater. Currently, there is no consensus on the treatments for IHCP, and the usefulness of immunosuppressive agents as a first-line option remains controversial. Cerebral venous sinus occlusion (CVSO) and cerebral venous sinus thrombosis (CVST) secondary to IHCP, which may cause progressive intracranial hypertension and venous obstructive parenchymal lesions, make the diagnosis and treatment of IHCP more complicated...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28705815/sigmoid-sinus-diverticulum-dehiscence-and-venous-sinus-stenosis-potential-causes-of-pulsatile-tinnitus-in-patients-with-idiopathic-intracranial-hypertension
#14
J A Lansley, W Tucker, M R Eriksen, P Riordan-Eva, S E J Connor
BACKGROUND AND PURPOSE: Pulsatile tinnitus is experienced by most patients with idiopathic intracranial hypertension. The pathophysiology remains uncertain; however, transverse sinus stenosis and sigmoid sinus diverticulum/dehiscence have been proposed as potential etiologies. We aimed to determine whether the prevalence of transverse sinus stenosis and sigmoid sinus diverticulum/dehiscence was increased in patients with idiopathic intracranial hypertension and pulsatile tinnitus relative to those without pulsatile tinnitus and a control group...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28699330/stabbing-headache-as-the-presenting-symptom-of-idiopathic-intracranial-hypertension
#15
Gulshan Yunisova, Ipek Güngör, Elif Kocasoy Orhan, Betül Baykan
No abstract text is available yet for this article.
July 2017: Headache
https://www.readbyqxmd.com/read/28679427/comparison-of-the-sagittal-sinus-cross-sectional-area-between-patients-with-multiple-sclerosis-hydrocephalus-intracranial-hypertension-and-spontaneous-intracranial-hypotension-a-surrogate-marker-of-venous-transmural-pressure
#16
Grant A Bateman, Jeannette Lechner-Scott, Ross Copping, Christopher Moeskops, Swee Leong Yap
There is evidence that patients with multiple sclerosis (MS) and hydrocephalus share some common pathophysiological mechanisms. Alterations in CSF pressure are known to affect cerebral venous sinus geometry. To further explore these mechanisms, we measured the superior sagittal sinus (SSS) cross-sectional area 3 cm above the torcular using T2 images in 20 MS, 10 spontaneous intracranial hypotension (SIH), 21 hydrocephalus and 20 idiopathic intracranial hypertension (IIH) patients and compared with 20 matched controls...
July 6, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28678218/idiopathic-intracranial-hypertension-in-males
#17
Hissah K Al Abdulsalam, Abdulrazag M Ajlan
Idiopathic intracranial hypertension (IIH) is a neurological condition characterized by increased intracranial pressure without an underlying intracranial pathology. This condition is rarely encountered in men and it predominantly affects obese women of childbearing age. We present an interesting case of IIH in a male patient who presented with acute severe vision loss over 2 weeks and was successfully treated via surgery. Although IIH is less common in men than in women, men are more likely to develop vision loss, which is usually severe and less likely to respond to medical treatment...
July 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28668233/incidence-and-demographics-of-pediatric-intracranial-hypertension
#18
Natalie Gillson, Charlotte Jones, Rachel E Reem, David L Rogers, Nicholas Zumberge, Shawn C Aylward
OBJECTIVE: We analyzed the incidence and demographic features of pediatric intracranial hypertension. METHODS: Inpatient and outpatient encounters of children aged 18 years or younger who were diagnosed with primary (idiopathic) or secondary intracranial hypertension between January 2010 and December 2013 were identified. Data were collected from a subspecialty clinic devoted to intracranial hypertension and the sole children's hospital in a large Midwestern city of the United States...
August 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28663268/increased-curvature-of-the-tentorium-cerebelli-in-idiopathic-intracranial-hypertension
#19
P P Morris, N Lachman, D F Black, R A Carter, J Port, N Campeau
BACKGROUND AND PURPOSE: Transverse sinus effacement is detectable on MRV examinations in almost all patients with idiopathic intracranial hypertension. This effacement of the transverse sinus is presumed to be mediated by elevation of intracranial pressure, resulting in compression and inward collapse of the dural margins of the sinus. We sought to establish whether supratentorial broad-based downward deformity of the tentorium might explain transverse sinus effacement in idiopathic intracranial hypertension...
June 29, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28637822/pattern-of-pressure-gradient-alterations-after-venous-sinus-stenting-for-idiopathic-intracranial-hypertension-predicts-stent-adjacent-stenosis-a-proposed-classification-system
#20
Daniel Raper, Thomas J Buell, Dale Ding, Ching-Jen Chen, Robert M Starke, Kenneth C Liu
OBJECTIVE: Venous sinus stenting (VSS) is a safe and effective treatment for idiopathic intracranial hypertension (IIH) with angiographic venous sinus stenosis. However, predictors of stent-adjacent stenosis (SAS) remain poorly defined. METHODS: We performed a retrospective review of 47 patients with IIH and intracranial venous stenosis who underwent VSS with pre- and post-stent venography. Patient characteristics, treatments and outcomes were reviewed. Changes in pressure gradient after VSS were classified according to pattern of gradient resolution into types I-III...
June 21, 2017: Journal of Neurointerventional Surgery
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