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https://www.readbyqxmd.com/read/27905649/-hyperinsulinemia-and-insulin-resistance-in-children
#1
Ana Beatriz Rosas-Sumano, Francisco Javier Rodal-Canales, Margarita Barrientos Pérez, Beatriz Eugenia Cárdenas-Morales, Laura Pérez-Campos Mayoral, Eduardo Pérez-Campos
BACKGROUND: Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood. AIM: To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. MATERIAL AND METHODS: Comparative study of 21 obese children with a body mass index (BMI) over percentile 95, aged 10 ± 1 years (10 males), 14 children aged 10 ± 2 (7 males) with a BMI between percentiles 85 and 94 and 16 children aged 9 ± 2 years (3 males) with a body mass index between percentiles 10 and 84...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27754144/os-28-02-renal-denervation-alters-adipokine-levels-in-patients-with-resistant-hypertension
#2
Markus Schlaich, Dagmara Hering, Petra Marusic, Antony Walton, Elisabeth Lambert, Henry Krum, Gavin Lambert, Murray Esler, Nina Eikelis
OBJECTIVE: We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) in part via the reduction of renal sympathetic activity. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favorable outcome on adipokine profile in patients with resistant hypertension (RH). DESIGN AND METHOD: Fifty seven patients with RH undergoing RDN have been recruited for the study (65% males, age 60...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643074/os-28-02-renal-denervation-alters-adipokine-levels-in-patients-with-resistant-hypertension
#3
Markus Schlaich, Dagmara Hering, Petra Marusic, Antony Walton, Elisabeth Lambert, Henry Krum, Gavin Lambert, Murray Esler, Nina Eikelis
OBJECTIVE: We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) in part via the reduction of renal sympathetic activity. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favorable outcome on adipokine profile in patients with resistant hypertension (RH). DESIGN AND METHOD: Fifty seven patients with RH undergoing RDN have been recruited for the study (65% males, age 60...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27564297/improvement-of-erectile-dysfunction-by-the-active-pepide-from-urechis-unicinctus-by-high-temperature-pressure-and-ultra-wave-assisted-lysis-in-streptozotocin-induced-diabetic-rats
#4
Kang Sup Kim, Woong Jin Bae, Su Jin Kim, Kyong-Hwa Kang, Se-Kwon Kim, Hyuk Jin Cho, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim
INTRODUCTION: We investigate the effect of active peptide from Urechis unicinctus (UU) by high temperature/pressure and ultra-wave assisted lysis on erectile dysfunction in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Forty 12-week-old Sprague-Dawley rats were used in this study. Diabetes was induced by a one-time intraperitoneal injection of streptozotocin (50mg/kg). One week later, the diabetic rats were randomly divided into four groups: normal control, untreated diabetes control, and groups treated with 100 or 500mg/kg/d UU peptide...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27508852/-op-7d-10-the-effect-of-renal-denervation-on-adipokines-in-patients-with-resistant-hypertension
#5
N Eikelis, D Hering, P Marusic, A Walton, E Lambert, H Krum, G Lambert, M Esler, M Schlaich
OBJECTIVE: We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. Obesity also contributes to hypertension. A number of adipocyte-derived factors (collectively termed 'adipokines') have been implicated in BP control. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favourable outcome on adipokine profile in patients with resistant hypertension (RH)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/25684089/plant-based-no-added-fat-or-american-heart-association-diets-impact-on-cardiovascular-risk-in-obese-children-with-hypercholesterolemia-and-their-parents
#6
RANDOMIZED CONTROLLED TRIAL
Michael Macknin, Tammie Kong, Adam Weier, Sarah Worley, Anne S Tang, Naim Alkhouri, Mladen Golubic
OBJECTIVE: To perform a randomized trial to determine whether there is cardiovascular disease (CVD) risk reduction from a plant-based (PB), no-added-fat diet and the American Heart Association (AHA) diet in children. STUDY DESIGN: A 4-week (April 20, 2013 to May 18, 2013), prospective randomized trial was undertaken in a large, Midwestern hospital system's predominantly middle class outpatient pediatric practices. Thirty children (9-18 years of age) parent pairs with a last recorded child body mass index >95th percentile and child cholesterol >169 mg/dL were randomized to PB or AHA with weekly 2-hour classes of nutrition education...
April 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/22774383/characterization-of-metabolically-unhealthy-overweight-obese-african-american-women-significance-of-insulin-sensitive-and-insulin-resistant-phenotypes
#7
COMPARATIVE STUDY
Trudy R Gaillard, Dara Schuster, Kwame Osei
BACKGROUND: Obesity is often associated with high cardiovascular disease risk factors. Obesity is common in African American women. We investigated the characteristics of metabolically healthy and metabolically unhealthy overweight/obese African American women based on the presence of insulin resistance. MATERIALS/METHODS: We studied 196 apparently healthy overweight/obese African American women with family history of type 2 diabetes. Waist circumference, fasting glucose, insulin, c-peptide, lipids and lipoproteins, and systolic and diastolic blood pressure were obtained in each subject...
March 2012: Journal of the National Medical Association
https://www.readbyqxmd.com/read/22152105/the-genomic-features-that-affect-the-lengths-of-5-untranslated-regions-in-multicellular-eukaryotes
#8
Chun-Hsi Chen, Hsuan-Yu Lin, Chia-Lin Pan, Feng-Chi Chen
BACKGROUND: The lengths of 5'UTRs of multicellular eukaryotes have been suggested to be subject to stochastic changes, with upstream start codons (uAUGs) as the major constraint to suppress 5'UTR elongation. However, this stochastic model cannot fully explain the variations in 5'UTR length. We hypothesize that the selection pressure on a combination of genomic features is also important for 5'UTR evolution. The ignorance of these features may have limited the explanatory power of the stochastic model...
2011: BMC Bioinformatics
https://www.readbyqxmd.com/read/20000915/comparison-of-three-measurement-techniques-for-the-normal-absorption-coefficient-of-sound-absorbing-materials-in-the-free-field
#9
Kunikazu Hirosawa, Kazuhiro Takashima, Hiroshi Nakagawa, Makoto Kon, Aki Yamamoto, Walter Lauriks
Three different techniques for evaluating the absorption coefficient of sound absorbing materials in free field conditions are discussed. One technique measures the acoustic impedance at one point nearby a specimen, the other two techniques evaluate the impedance from the transfer function of two sound pressures and two particle velocities at two points. These are called "PU-method," "PP-method," and "UU-method," respectively. An iterative algorithm to estimate the acoustic impedance of the locally reactive specimen in the spherical wave field is also applied...
December 2009: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/17604869/hepatitis-c-virus-rna-dinucleotide-frequencies-and-cleavage-by-rnase-l
#10
Christopher L Washenberger, Jian-Qiu Han, Katherina J Kechris, Babal Kant Jha, Robert H Silverman, David J Barton
Ribonuclease L (RNase L) is an antiviral endoribonuclease that cleaves hepatitis C virus (HCV) RNA at single-stranded UA and UU dinucleotides throughout the open reading frame (ORF). To determine whether RNase L exerts evolutionary pressure on HCV we examined the frequencies of UA and UU dinucleotides in 162 RNA sequences from the Los Alamos National Labs HCV Database (http://hcv.lanl.gov). Considering the base composition of the HCV ORFs, both UA and UU dinucleotides were less frequent than predicted in each of 162 HCV RNAs...
December 2007: Virus Research
https://www.readbyqxmd.com/read/17132879/fasting-insulin-adiponectin-hs-crp-levels-and-the-components-of-metabolic-syndrome
#11
Fabiola M S Adam, Mario G B Nara, John M F Adam
AIM: in this study we report the relationship between fasting plasma insulin, C-reactive protein, adiponectin levels and the components of metabolic syndrome. METHODS: for the diagnosis of metabolic syndrome we used the modified NCEP ATP criteria for Asian people. Complete routine physical examinations were performed to all subjects including blood pressure, waist circumference. After 12-hours fasting, blood sample was taken for fasting plasma glucose, fasting insulin, and lipid profiles...
October 2006: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/16865342/preparative-hplc-separation-of-bambuterol-enantiomers-and-stereoselective-inhibition-of-human-cholinesterases
#12
Ivana Gazić, Anita Bosak, Goran Sinko, Vladimir Vinković, Zrinka Kovarik
We separated and characterized the enantiomers of bambuterol (5-[-(tert-butylamino)-1-hydroxyethyl]-m-phenylene-bis(dimethylcarbamate) hydrochloride), which is used in racemic form as a prodrug of terbutaline, a beta(2)-adrenoceptor agonist. The enantioseparation was attempted on several chiral HPLC columns, and the most effective separation was achieved on the amylose-based Chiralpak AD column. Since in vivo conversion of bambuterol into terbutaline involves hydrolysis by butyrylcholinesterase (EC 3.1.1.8), we studied the reaction of enantiomers with eight human BChE variants...
August 2006: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/12930907/effects-of-antenatal-colonization-with-ureaplasma-urealyticum-on-pulmonary-disease-in-the-immature-baboon
#13
Bradley A Yoder, Jacqueline J Coalson, Vicki T Winter, Teresa Siler-Khodr, Lynne B Duffy, Gail H Cassell
Current nonhuman models for bronchopulmonary dysplasia have not included perinatal infection. We studied the effects of antenatal Ureaplasma urealyticum (Uu) infection in the 125-d immature baboon. Ten 125-d gestation (term = 185 d) baboon dams were delivered after intra-amniotic inoculation with Uu. Serial blood and tracheal aspirate samples were analyzed for Uu colony-forming units, IL-6, IL-8, and cell counts. Physiologic parameters were serially recorded. Lung histology was examined after 14 d of ventilation and compared with unexposed controls...
December 2003: Pediatric Research
https://www.readbyqxmd.com/read/12819902/insulin-sensitivity-and-cardiovascular-risk-factors-in-hypertensive-and-normotensive-native-ghanaians
#14
A G B Amoah, D P Schuster, T Gaillard, K Osei
AIMS/HYPOTHESIS: The objective of this study was to examine the relationships among insulin and insulin sensitivity and risk factors for cardiovascular diseases in native Ghanaians with and without hypertension. METHODS: We measured the anthropometric parameters, systolic and diastolic blood pressure, fasting serum triglycerides, cholesterol and high-density lipoprotein cholesterol and fasting and stimulated glucose, insulin and C-peptide of 200 Ghanaian subjects, who were between 25 to 74 years of age, and residing in the Accra Metropolitan area...
July 2003: Diabetologia
https://www.readbyqxmd.com/read/12790074/-insulin-resistance-and-other-expressions-of-metabolic-syndrome-in-obese-chilean-children
#15
Salesa Barja, Antonio Arteaga, Ana M Acosta, M Isabel Hodgson
BACKGROUND: Infantile obesity is a probable risk factor for the early appearance of chronic illnesses like Type 2 Diabetes Mellitus, Dislipidemia and Hypertension. Insulin Resistance (IR) appears as the common etiological mechanism. AIM: To describe metabolic complications associated to obesity in a group of Chilean children and to correlate them with IR, estimated through the homeostasis model assessment index (HOMA). SUBJECTS AND METHODS: We studied 88 children, 12 +/- 2...
March 2003: Revista Médica de Chile
https://www.readbyqxmd.com/read/11738097/multicenter-randomized-controlled-trial-comparing-different-schedules-of-somatostatin-in-the-treatment-of-acute-variceal-bleeding
#16
RANDOMIZED CONTROLLED TRIAL
E Moitinho, R Planas, R Bañares, A Albillos, L Ruiz-del-Arbol, C Gálvez, J Bosch
BACKGROUND/AIMS: The dose of somatostatin used for variceal bleeding (250 microg/h) is lower than that proven to effectively decrease portal pressure and azygos blood flow (500 microg/h). Moreover, i.v. somatostatin boluses have greater effects than continuous infusions. The aim of this study was to investigate whether higher doses of somatostatin and repeated boluses may increase its efficacy in controlling variceal bleeding. METHODS: A total of 174 patients with acute variceal bleeding were randomized to receive for 48 h: (A) one 250 microg bolus +250 microg/h infusion; (B) three 250 microg boluses +250 microg/h infusion; (C) three 250 microg boluses +500 microg/h infusion...
December 2001: Journal of Hepatology
https://www.readbyqxmd.com/read/10464138/prognostic-value-of-early-measurements-of-portal-pressure-in-acute-variceal-bleeding
#17
E Moitinho, A Escorsell, J C Bandi, J M Salmerón, J C García-Pagán, J Rodés, J Bosch
BACKGROUND & AIMS: Variceal bleeding is the most important complication of portal hypertension. However, the relationship between the increase in portal pressure and the outcome of variceal bleeding has not been well defined. METHODS: We measured the hepatic venous pressure gradient (HVPG) of 65 cirrhotic patients with acute variceal hemorrhage, early after admission (20.6 +/- 15.6 hours). RESULTS: Twenty-three patients had a poor evolution (failure to control bleeding or early variceal rebleeding), and 42 had an uneventful evolution...
September 1999: Gastroenterology
https://www.readbyqxmd.com/read/9309627/effects-of-cross-training-on-markers-of-insulin-resistance-hyperinsulinemia
#18
RANDOMIZED CONTROLLED TRIAL
M B Wallace, B D Mills, C L Browning
This study examined, through a randomized controlled trial, the effects of cross-training (combined resistance and endurance exercise) on markers of insulin resistance, (e.g., dyslipidemia, intra-abdominal obesity, hyperinsulinemia, and hypertension), body composition, and performance in hyperinsulinemic individuals. Sedentary adult males characterized as hyperinsulinemic (fasting insulin > 2 OuU.mL-1), randomly assigned to two groups (N = 8 each), completed 14 wk of training at 3 d.wk-1. An endurance-only (E) group performed both continuous cycle exercise and walking (30 min each at 60-70% heart rate reserve)...
September 1997: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/8872834/metabolic-humoral-and-haemodynamic-characteristics-of-normotensive-offspring-from-hypertensive-families
#19
K Horký, M Jáchymová, A Jindra, J Savliková, J Peleska, V Umnerová, A Linhart
Arterial hypertension is not only a haemodynamic abnormality, but it is associated with several metabolic and humoral changes. Heredity appears to be participating in the pathogenesis of essential hypertension (EH). We studied whether some metabolic, humoral and haemodynamic changes could be detected in genetically predisposed normotensive sons of hypertensive families (SH) compared with normotensive sons of normotensive parents (SN). The study groups consisted of 40 young SN and 40 SH matched for age and body mass index (BMI)...
September 1996: Journal of Human Hypertension
https://www.readbyqxmd.com/read/6169260/the-2-5a-pppa2-p5-a2-p5-a-and-protein-kinase-systems-in-interferon-treated-and-control-cells
#20
I M Kerr, D H Wreschner, R H Silverman, P J Cayley, M Knight
With respect to interferon action in general: multisite models and analogies with hormone action are in vogue. More particularly, concerning the 2-5A system, the structure of 2-5A has been confirmed. We know that in the cell-free system and intact cell it is unstable and in the absence of a regenerating system transiently activates a nuclease. This nuclease shows some specificity; preferentially cleaving RNA on the 3'-side of UN doublets (UA and UU are preferred). When introduced into the intact cell 2-5A can inhibit protein and DNA synthesis and virus growth...
1981: Advances in Cyclic Nucleotide Research
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