keyword
https://read.qxmd.com/read/34862042/nutrition-in-kidney-disease-core-curriculum-2022
#21
REVIEW
Helen L MacLaughlin, Allon N Friedman, T Alp Ikizler
As chronic kidney disease (CKD) progresses, the requirements and utilization of different nutrients change substantially. These changes are accompanied by multiple nutritional and metabolic abnormalities that are observed in the continuum of kidney disease. To provide optimal care to patients with CKD, it is essential to have an understanding of the applicable nutritional principles: methods to assess nutritional status, establish patient-specific dietary needs, and prevent or treat potential or ongoing nutritional deficiencies and derangements...
March 2022: American Journal of Kidney Diseases
https://read.qxmd.com/read/34783494/end-stage-renal-disease-medical-management
#22
JOURNAL ARTICLE
Noah Wouk
End-stage renal disease (ESRD) is diagnosed when kidney function is no longer adequate for long-term survival without kidney transplantation or dialysis. Primary care clinicians should refer people at risk of ESRD to nephrology to optimize disease management. Kidney transplantation typically yields the best patient outcomes, although most patients are treated with dialysis. The decision to initiate dialysis is best made through shared decision-making. Because most patients with ESRD elect to receive hemodialysis, the preservation of peripheral veins is important for those with stage III to V chronic kidney disease...
November 1, 2021: American Family Physician
https://read.qxmd.com/read/34772602/loneliness-an-overlooked-contributing-factor-in-anorexia-of-older-patients-with-end-stage-renal-disease-and-focal-point-for-interventions-to-enhance-nutritional-status-an-overview-of-evidence-and-areas-of-suggested-research
#23
REVIEW
William A Wolfe
Although research has shown that loneliness can contribute to anorexia in older non-ESRD (end-stage renal disease) populations, and the benefits of its mitigation with improving appetite, nutrient, and caloric intake, its implications for older patients with ESRD have been overlooked. This article provides an overview of evidence on the potential contributing role of loneliness in anorexia of older patients with ESRD, and loneliness as a focal point for interventions to help improve nutritional status. Areas of needed research are suggested in the course of the analysis...
November 9, 2021: Journal of Renal Nutrition
https://read.qxmd.com/read/34676694/effects-of-hormonal-changes-on-sarcopenia-in-chronic-kidney-disease-where-are-we-now-and-what-can-we-do
#24
REVIEW
Ozkan Gungor, Sena Ulu, Nuri Baris Hasbal, Stefan D Anker, Kamyar Kalantar-Zadeh
Sarcopenia or muscle wasting is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function, often associated with muscle weakness (dynapenia) and frailty. Whereas primary sarcopenia is related to ageing, secondary sarcopenia happens independent of age in the context of chronic disease states such as chronic kidney disease (CKD). Sarcopenia has become a major focus of research and public policy debate due to its impact on patient's health-related quality of life, health-care expenditure, morbidity, and mortality...
December 2021: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/34445030/independent-determinants-of-appetite-impairment-among-patients-with-stage-3-or-higher-chronic-kidney-disease-a-prospective-study
#25
JOURNAL ARTICLE
Chih-Chien Sung, Min-Tser Liao, Chia-Ter Chao
Protein-energy wasting (PEW) is an important complication resulting from chronic kidney disease (CKD). Appetite impairment contributes significantly to PEW in these patients, but risk factors associated with having appetite impairment in patients with CKD remain elusive. Patients with an estimated glomerular filtration rate <60 mL/min/1.73 m2 for ≥2 times at least three months apart were prospectively enrolled during 2017, with their demographic features, comorbidities, anthropometric parameters, physical and performance indices, functional status, frailty, sensory organ integrity, and laboratory data collected...
August 20, 2021: Nutrients
https://read.qxmd.com/read/34357038/relationship-between-vascular-calcification-protein-energy-wasting-syndrome-and-sarcopenia-in-maintenance-automated-peritoneal-dialysis
#26
JOURNAL ARTICLE
Gustavo Leal-Alegre, Claudia Lerma, Gabriela Leal-Escobar, Bernardo Moguel-González, Karen Belén Martínez-Vázquez, Karla Berenice Cano-Escobar
Vascular calcifications affect 80% to 90% of chronic kidney disease patients and are a predictive factor of cardiovascular mortality. Sarcopenia and protein-energy wasting syndrome are also associated with mortality. The aim was to assess the relationship between vascular calcification, sarcopenia, and protein-energy wasting syndrome (PEW) in automated peritoneal dialysis patients. Fifty-one maintenance automated peritoneal dialysis patients were included (27 were male, mean age 39 ± 14 years). Vascular calcification was assessed based on abdomen, pelvis, and hand radiographs...
July 7, 2021: Life
https://read.qxmd.com/read/34343991/nutrition-and-obesity-impacts-on-kidney-health
#27
REVIEW
Angela Yee-Moon Wang, Csaba P Kovesdy
Clinical Background and Epidemiology: Nutrition and obesity are both important and common clinical issues in chronic kidney disease (CKD). Protein-energy wasting predicts adverse clinical outcomes in CKD. Obesity is associated with poor health outcomes. Nutrition management, specifically a protein-restricted diet, has been shown to ameliorate glomerular injury and progressive CKD by reducing glomerular hyperfiltration and hypertension. A protein-restricted diet has favorable metabolic and hemodynamic effects and effects on CKD-mineral bone disease that may favorably impact patients' outcomes...
2021: Contributions to Nephrology
https://read.qxmd.com/read/34286938/appetite-stimulants-for-treatment-of-protein-energy-wasting-of-chronic-kidney-disease
#28
REVIEW
Anne Marie Liles, Anastasia B Jenkins, Hayden Hendrix, Emily Johnson, Hillary Rowe, Katie S McClendon
Nutritional and metabolic abnormalities, or protein energy wasting, is a common complication of chronic kidney disease, leading to significant morbidity and mortality. The cause of these abnormalities is multifactorial, and therefore, difficult to treat. The International Society of Renal Nutrition and Metabolism suggests appetite stimulants, including megestrol, dronabinol, mirtazapine, and cyproheptadine, as adjunctive treatment options in addition to parenteral or oral nutritional supplementation. This article reviews the evidence for use of these drugs as appetite stimulants and discusses their use in patients with chronic kidney disease...
2021: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://read.qxmd.com/read/34053197/protein-energy-wasting-and-long-term-outcomes-in-nondialysis-dependent-chronic-kidney-disease
#29
JOURNAL ARTICLE
Bryan B Franco, Wilma M Hopman, Michelle C Lamarche, Rachel M Holden
BACKGROUND: Nutritional status and protein energy wasting (PEW) is prevalent in patients with nondialysis-dependent chronic kidney disease (CKD). The relationship between PEW and long-term development of clinically important outcomes remains to be examined. OBJECTIVES: To investigate the relationships between PEW, as measured by Subjective Global Assessment (SGA 1-7), and progression to important clinical outcomes: mortality and/or kidney failure. DESIGN: Prospective cohort design...
March 2022: Journal of Renal Care
https://read.qxmd.com/read/33891249/molecular-insight-into-optimizing-the-n-and-p-doped-fullerenes-for-urea-removal-in-wearable-artificial-kidneys
#30
JOURNAL ARTICLE
Ahmad Miri Jahromi, Pegah Zandi, Mohammad Khedri, Ebrahim Ghasemy, Reza Maleki, Lobat Tayebi
Urea is the result of the breakdown of proteins in the liver, the excess of which circulates in the blood and is adsorbed by the kidneys. However, in the case of kidney diseases, some products, specifically urea, cannot be removed from the blood by the kidneys and causes serious health problems. The end-stage renal disease (ESRD) patients are not able to purify their blood, which endangers their life. ESRD patients require dialysis, a costly and difficult method of urea removal from the blood. Wearable artificial kidneys (WAKs) are consequently designed to remove the waste from blood...
April 23, 2021: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/33888409/a-comparison-of-dietary-intake-between-individuals-undergoing-maintenance-hemodialysis-in-the-united-kingdom-and-china
#31
JOURNAL ARTICLE
Yan Song, Daniel S March, Annabel Biruete, Brandon M Kistler, Daniel D G Nixon, Patrick J Highton, Barbara P Vogt, Nicola Ruddock, Kenneth R Wilund, Alice C Smith, James O Burton
OBJECTIVE: Protein-energy wasting is highly prevalent in people with end-stage kidney disease receiving regular hemodialysis. Currently, it is unclear what the optimal nutritional recommendations are, which is further complicated by differences in dietary patterns between countries. The aim of the study was to understand and compare dietary intake between individuals receiving hemodialysis in Leicester, UK and Nantong, China. METHODS: The study assessed 40 UK and 44 Chinese participants' dietary intake over a period of 14 days using 24-hour diet recall interviews...
April 19, 2021: Journal of Renal Nutrition
https://read.qxmd.com/read/33601382/impact-of-circulating-n-acylethanolamine-levels-with-clinical-and-laboratory-end-points-in-hemodialysis-patients
#32
JOURNAL ARTICLE
Alex Y Pai, Cachet Wenziger, Elani Streja, Donovan A Argueta, Nicholas V DiPatrizio, Connie M Rhee, Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli, Hamid Moradi
BACKGROUND: Patients with ESRD on maintenance hemodialysis (MHD) are particularly susceptible to dysregulation of energy metabolism, which may manifest as protein energy wasting and cachexia. In recent years, the endocannabinoid system has been shown to play an important role in energy metabolism with potential relevance in ESRD. N-acylethanolamines are a class of fatty acid amides which include the major endocannabinoid ligand, anandamide, and the endogenous peroxisome proliferator-activated receptor-α agonists, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)...
February 18, 2021: American Journal of Nephrology
https://read.qxmd.com/read/33597108/ketoanalogue-supplements-reduce-mortality-in-patients-with-pre-dialysis-advanced-diabetic-kidney-disease-a-nationwide-population-based-study
#33
JOURNAL ARTICLE
Hsing-Yu Chen, Chiao-Yin Sun, Chin-Chan Lee, I-Wen Wu, Yung-Chang Chen, Yi-Hsuan Lin, Wei-Ching Fang, Heng-Chih Pan
BACKGROUND & AIMS: Metabolism dysregulation and protein energy wasting occur in patients with chronic kidney disease (CKD) and are associated with poor survival, especially in patients prior to starting dialysis. Accumulating evidence indicates that dietary supplementation with ketoanalogues (KAs, a mixture of branched-chain amino acids) exerts a variety of beneficial effects for patients with CKD. However, the role of KAs in diabetic kidney disease (DKD), one of the major causes of CKD, is still controversial...
June 2021: Clinical Nutrition
https://read.qxmd.com/read/32708829/exploring-metabolic-signature-of-protein-energy-wasting-in-hemodialysis-patients
#34
JOURNAL ARTICLE
Fatin Athirah Pauzi, Sharmela Sahathevan, Ban-Hock Khor, Sreelakshmi Sankara Narayanan, Nor Fadhlina Zakaria, Faridah Abas, Tilakavati Karupaiah, Zulfitri Azuan Mat Daud
End-stage renal disease patients undergoing maintenance hemodialysis (HD) are vulnerable to the protein energy wasting (PEW) syndrome. Identification and diagnosis of PEW relies on clinical processes of judgment dependent on fulfilling multiple criteria drawn from serum biochemistry, weight status, predictive muscle mass, dietary energy and protein intakes. Therefore, we sought to explore the biomarkers' signature with plasma metabolites of PEW by using 1 H-nuclear magnetic resonance for an untargeted metabolomics approach in the HD population, to understand metabolic alteration of PEW...
July 16, 2020: Metabolites
https://read.qxmd.com/read/31940069/aortic-dilatation-in-children-with-mild-to-moderate-chronic-kidney-disease
#35
JOURNAL ARTICLE
Peace C Madueme, Derek K Ng, Luke Guju, Lauren Longshore, Vicky Moore, Lynn Jefferies, Bradley A Warady, Susan Furth, Mark Mitsnefes
BACKGROUND: Children with mild to moderate chronic kidney disease are at an increased risk for cardiovascular sequelae, the leading cause of death in children with end-stage renal disease. We aimed to establish the prevalence of aortic dilatation, a newly recognized cardiovascular sequelae of renal disease, within a cohort of pediatric patients with mild to moderate kidney disease. METHODS: A total of 501 children enrolled in the Chronic Kidney Disease in Children study contributed imaging data between April 2011 and February 2015...
June 2020: Pediatric Nephrology
https://read.qxmd.com/read/31851983/a-practical-approach-to-nutrition-protein-energy-wasting-sarcopenia-and-cachexia-in-patients-with-chronic-kidney-disease
#36
REVIEW
Ramy M Hanna, Lena Ghobry, Olivia Wassef, Connie M Rhee, Kamyar Kalantar-Zadeh
Objectives of Review: Protein-energy wasting (PEW) is a state of disordered catabolism resulting from metabolic and nutritional derangements in chronic disease states. Patients with chronic kidney disease (CKD), and end-stage renal disease (ESRD) in particular, have muscle wasting, sarcopenia, and cachexia that contribute to frailty and morbidity. Moreover, reverse epidemiology findings have strongly linked PEW with mortality in CKD and ESRD. Updated Findings: The malnutrition-inflammation score (KALANTAR Score) provides a useful tool to predict nutritional risk...
2020: Blood Purification
https://read.qxmd.com/read/31215878/the-role-of-myostatin-and-protein-kinase-b-in-the-development-of-protein-energy-deficiency-in-patients-with-end-stage-renal-disease-on-hemodialysis
#37
JOURNAL ARTICLE
A Kuzyarova, M Gasanov, M Batyushin, O Golubeva, M Najeva
In patients with chronic renal failure receiving hemodialysis, the development of protein-energy wasting (PEW) has a significant impact on the quality and duration of life. Myostatin (MSTN) and protein kinase-β (AKT) play an important role in this process. The aim of our study was to assess the contribution of these molecular markers of muscle metabolism to the development of PEW in patients with chronic kidney disease stage 5D (CKD5D). The study included 80 patients with CKD5D. All patients underwent anthropometric research, hand dynamometry, bio-impedancemetry...
April 2019: Georgian Medical News
https://read.qxmd.com/read/31181128/serum-albumin-and-mortality-in-patients-with-hiv-and-end-stage-renal-failure-on-peritoneal-dialysis
#38
JOURNAL ARTICLE
Kwazi Celani Zwakele Ndlovu, Perpetual Chikobvu, Thabiso Mofokeng, Verena Gounden, Alain Assounga
BACKGROUND: Peritoneal dialysis (PD) is an easily implementable dialysis modality in end-stage renal disease (ESRD). PD may improve access to renal replacement therapy in low- and middle-income countries; however, these countries have a higher prevalence of protein-energy wasting in patients and poorer socioeconomic conditions. We evaluated the effects of HIV infection on serum albumin levels in ESRD patients starting continuous ambulatory PD (CAPD) and mortality outcomes. METHODS: We conducted a single-center prospective cohort study of consecutive incident CAPD patients recruited from two hospitals in Durban, South Africa, from September 2012 to February 2015...
2019: PloS One
https://read.qxmd.com/read/31137583/do-transferrin-levels-predict-haemodialysis-adequacy-in-patients-with-end-stage-renal-disease
#39
JOURNAL ARTICLE
Giovanni Tarantino, Mauro Vinciguerra, Annalisa Ragosta, Vincenzo Citro, Paolo Conforti, Giovanni Salvati, Aniello Sorrentino, Luca Barretta, Clara Balsano, Domenico Capone
BACKGROUND: Since haemodialysis is a lifesaving therapy, adequate control measures are necessary to evaluate its adequacy and to constantly adjust the dose to reduce hospitalisation and prolong patient survival. Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. Patients undergoing haemodialysis have a high prevalence of protein-energy malnutrition and inflammation, along with abnormal iron status. The haemodialysis dose delivered is an important predictor of patient outcome...
May 20, 2019: Nutrients
https://read.qxmd.com/read/31119516/association-of-serum-il-18-with-protein-energy-wasting-in-end-stage-renal-disease-patients-on-haemodialysis
#40
JOURNAL ARTICLE
Xiao Bi, Mingzi Chu, Honglan Ai, Chun Hu, Wei Ding
PURPOSE: Protein-energy wasting (PEW) is highly prevalent in end-stage renal disease (ESRD) patients with inflammation who are on haemodialysis treatment. Interleukin-18 (IL-18) is an important pro-inflammatory cytokine that is significantly elevated in ESRD patients. However, the relationship between PEW and IL-18 is unclear. We therefore performed a cross-sectional study on 100 ESRD patients undergoing haemodialysis to clarify this. METHODS: PEW was defined according to the diagnostic criteria of the International Society of Renal Nutrition and Metabolism...
May 22, 2019: International Urology and Nephrology
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