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JOURNAL ARTICLE
Hyo Jin Gu, Do-Young Kim, Seung Hee Shin, Md Saidur Rahman, Hee-Seok Lee, Myung-Geol Pang, Jun-Mo Kim, Buom-Yong Ryu
Cumulative human exposure to the environmental toxin, bisphenol A (BPA), has raised important health concerns in recent decades. However, the direct genomic regulation of BPA in skeletal muscles and its clinical significance are poorly understood. Therefore, we conducted a genome-wide transcriptome analysis after daily oral administration of BPA at the lowest observed adverse-effect level (LOAEL, 50 mg/kg) in male mice for six weeks to explore the gene-expression regulations in skeletal muscle induced by BPA...
May 1, 2024: Environmental Research
#2
JOURNAL ARTICLE
Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst
INTRODUCTION: Chronic obstructive pulmonary disease is a systemic disease characterized not only by respiratory symptoms but also by physical deconditioning and muscle weakness. One prominent manifestation of this disease is the decline in respiratory muscle strength. Previous studies have linked the genotypes of insulin-like growth factor 1 and 2 (IGF-1 and IGF-2) to muscle weakness in other populations without this disease. However, there is a notable knowledge gap regarding the biological mechanisms underlying respiratory muscle weakness, particularly the role of IGF-1 and IGF-2 genotypes in this pulmonary disease...
April 30, 2024: Medwave
#3
Da Li, Hu Yu, Min Zhou, Weinv Fan, Qiongfeng Guan, Li Li
BACKGROUND: There is growing evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or COVID-19 infection is associated with the development of immune mediated neuropathies like chronic inflammatory demyelinating polyneuropathy (CIDP), but the impact of SARS-CoV-2 vaccination and COVID-19 infection on genetic disorders such as Charcot-MarieTooth (CMT) remains unclear. CASE PRESENTATION: A 42-year-old male with occulted CMT neuropathy type lA (CMT1A) who developed limb numbness and weakness after the second SARS-CoV-2-vaccination was confirmed by identifying characteristic repeats in the p11...
2024: Frontiers in Neurology
#4
Luca J Delfinis, Leslie M Ogilvie, Shahrzad Khajehzadehshoushtar, Shivam Gandhi, Madison C Garibotti, Arshdeep K Thuhan, Kathy Matuszewska, Madison Pereira, Ronald G Jones, Arthur J Cheng, Thomas J Hawke, Nicholas P Greene, Kevin A Murach, Jeremy A Simpson, Jim Petrik, Christopher G R Perry
OBJECTIVES: A high proportion of women with advanced epithelial ovarian cancer (EOC) experience weakness and cachexia. This relationship is associated with increased morbidity and mortality. EOC is the most lethal gynecological cancer, yet no preclinical cachexia model has demonstrated the combined hallmark features of metastasis, ascites development, muscle loss and weakness in adult immunocompetent mice. METHODS: Here, we evaluated a new model of ovarian cancer-induced cachexia with the advantages of inducing cancer in adult immunocompetent C57BL/6J mice through orthotopic injections of EOC cells in the ovarian bursa...
April 8, 2024: bioRxiv
#5
Vinit Deolikar, Sarang S Raut, Saket Toshniwal, Shilpa A Gaidhane, Sourya Acharya
Dermatomyositis represents a rare inflammatory myopathy that induces inflammation in the muscles or related tissues, including the blood vessels supplying these muscles. The precise pathogenesis of this condition remains unknown. Diagnosis typically relies on clinical indicators such as skin rashes, progressive muscle weakness, elevated serum muscle enzymes, abnormal electromyogram results, and muscle biopsy. In this case study, we report a fatal case of dermatomyositis in a 23-year-old female patient who succumbed to complications of dermatomyositis, causing mortality without any evidence of malignancy...
March 2024: Curēus
#6
Prajyot Ankar, Snehal Samal, Swarna Singh
This case study examines the rehabilitation strategy for a 51-year-old farmer with primary neoplasm of the central nervous system (CNS)-related hemiparesis, balance issues, and cognitive impairment. Primary neoplasm of the CNS is a rare type of cancer that affects the brain, spinal cord, and other parts of the CNS. Hemiparesis, which is weakness on one side of the body, is a common symptom of primary neoplasm of the CNS. The tumour can cause inflammation and swelling in the brain, which can further contribute to weakness...
March 2024: Curēus
#7
JOURNAL ARTICLE
Rongrong Du, Peng Chen, Mao Li, Yahui Zhu, Zhengqing He, Xusheng Huang
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which leads to muscle weakness and eventual paralysis. Numerous studies have indicated that mitophagy and immune inflammation have a significant impact on the onset and advancement of ALS. Nevertheless, the possible diagnostic and prognostic significance of mitophagy-related genes associated with immune infiltration in ALS is uncertain. The purpose of this study is to create a predictive model for ALS using genes linked with mitophagy-associated immune infiltration...
2024: Frontiers in Immunology
#8
Gebrehiwot Lema Legese, Yeabsira Aklilu Tesfaye, Eleni Ayele, Desalew Getahun Ayalew, Aron Girma Abebaw, Tiruzer Bekele Gurji, Abilo Tadesse
BACKGROUND: Dermatomyositis is an inflammatory myopathies causing proximal muscle weakness accompanied by muscular inflammation and skin rash. Dermatomyositis patients have a higher incidence of malignancy as compared to the general population. CASE REPORT: A 52-year-old known female patient with a toxic multi-nodular goiter presented with insidious onset of itchy erythematous rash on her neck and bilateral hands and progressive muscle weakness of 4 months' duration...
2024: International Medical Case Reports Journal
#9
JOURNAL ARTICLE
Emily McLeish, Anuradha Sooda, Nataliya Slater, Kelly Beer, Ian Cooper, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert
OBJECTIVE: Inclusion body myositis (IBM) is a progressive late-onset muscle disease characterised by preferential weakness of quadriceps femoris and finger flexors, with elusive causes involving immune, degenerative, genetic and age-related factors. Overlapping with normal muscle ageing makes diagnosis and prognosis problematic. METHODS: We characterised peripheral blood leucocytes in 81 IBM patients and 45 healthy controls using flow cytometry. Using a random forest classifier, we identified immune changes in IBM compared to HC...
2024: Clinical & Translational Immunology
#10
JOURNAL ARTICLE
Kasper Yde Jensen, Jakob Lindberg Nielsen, Per Aagaard, Mikkel Jacobsen, Anders Nørkær Jørgensen, Rune Dueholm Bech, Ulrik Frandsen, Louise Pyndt Diederichsen, Henrik Daa Schrøder
Sporadic inclusion body myositis (sIBM) is a subgroup of idiopathic inflammatory myopathies characterised by progressive muscle weakness and skeletal muscle inflammation. Quantitative data on the myofibre morphology in sIBM remains scarce. Further, no previous study has examined fibre type association of satellite cells (SC), myonuclei number, macrophages, capillaries, and myonuclear domain (MD) in sIBM patients. Muscle biopsies from sIBM patients (n = 18) obtained previously (NCT02317094) were included in the analysis for fibre type-specific myofibre cross-sectional area (mCSA), SCs, myonuclei and macrophages, myonuclear domain, and capillarisation...
April 6, 2024: Rheumatology International
#11
REVIEW
Dilek Celik, Manuela Campisi, Luana Cannella, Sofia Pavanello
Sarcopenia, a musculoskeletal disease characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, presents significant challenges to global public health due to its adverse effects on mobility, morbidity, mortality, and healthcare costs. This comprehensive review explores the intricate connections between sarcopenia and low birth weight (LBW), emphasizing the developmental origins of health and disease (DOHaD) hypothesis, inflammatory processes (inflammaging), mitochondrial dysfunction, circadian rhythm disruptions, epigenetic mechanisms, and genetic variations revealed through genome-wide studies (GWAS)...
March 29, 2024: Journal of Cachexia, Sarcopenia and Muscle
#12
JOURNAL ARTICLE
Gabriela Salim de Castro, Leonardo R Gama, Alexandre Ferreira Ramos, Guilherme Gatti da Silva, Alexandre Abilio de Souza Teixeira, Edecio Cunha-Neto, Heraldo Possolo de Souza, Suely K Marie, Leda L Talib, Verônica Coelho, Jorge Kalil, Adriana Ladeira de Araujo, Ana Paula Ritto, Alessandro Rodrigo Belon, Amanda Soares Santos, Ana Paula Noronha Barrére, Márcio V Y Sawamura, Celina Almeida Lamas, Bruno Guedes Baldi, Carlos R R Carvalho, Leslie Domenici Kulikowski, Rodolfo Furlan Damiano, Marta Imamura, José Cesar Rosa Neto, Fabio S Lira, José Pinhata Otoch, Euripedes Constantino Miguel, Linamara Battistella, Orestes V Forlenza, Geraldo Busatto, Marilia Seelaender
INTRODUCTION: Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both the persistent and post-acute disease newly acquired symptoms are not yet fully described. Given the lack of robust knowledge regarding the mechanisms of PCC we have examined the impact of inflammation in PCC, by evaluating serum cytokine profile and its potential involvement in inducing the different symptoms reported...
2024: Frontiers in Nutrition
#13
JOURNAL ARTICLE
Maximilian Webendoerfer, Margarethe Konik, Markus Zettler, Johannes Wienker, Josefine Rawitzer, Stefan Esser, Jan Kehrmann, Ken Herrmann, Hans Christian Reinhardt, Oliver Witzke, Sebastian Dolff
INTRODUCTION: Granulomatosis due to immune reconstitution inflammatory syndrome (IRIS) and disseminated Mycobacterium avium-intracellulare (M. avium) infection may trigger hypercalcemia. Here, we report a rare case of hypercalcemia and acute kidney damage related to IRIS in a person living with Human Immunodeficiency Virus (HIV). CASE PRESENTATION: A 39-year-old male person living with HIV presented with muscle weakness and unwanted weight loss of 8 kg within the last 2 weeks...
March 23, 2024: Infection
#14
JOURNAL ARTICLE
Elisabeth Maillart, Stefania Redolfi, Céline Louapre, Marion Houot, Emeline Chaugne, Pierantonio Laveneziana, Aurelian Ungureanu, Bruno Stankoff, Isabelle Arnulf, Caroline Papeix, Benedetta Bodini, Thomas Similowski, Catherine Lubetzki, Capucine Morélot-Panzini
BACKGROUND: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. METHODS: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep...
March 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
#15
JOURNAL ARTICLE
Mingxing Lei, Taojin Feng, Mingming Zhang, Feifan Chang, Jiang Liu, Baisheng Sun, Ming Chen, Yi Li, Licheng Zhang, Peifu Tang, Pengbin Yin
Background: Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation. This study aims to develop a mouse model of PICS combined with bone trauma to investigate the mechanisms underlying muscle weakness, with a focus on SAA...
March 1, 2024: Shock
#16
JOURNAL ARTICLE
Nur Syafiqah Mohamad Ishak, Midori Kikuchi, Kazuto Ikemoto
Background: Understanding and promoting healthy aging has become a necessity in the modern world, where life expectancy is rising. The prospective benefits of the antioxidant pyrroloquinoline quinone (PQQ) in healthy aging are promising. However, its role in aging remains unclear. Thus, this study aimed to investigate the effect of PQQ on preventing the progression of aging and to explore its underlying molecular mechanisms. Methods: Naturally aged C57BL/6J male mice were fed a normal diet with or without PQQ (20 mg/kg/day) for 10 weeks...
2024: Front Aging
#17
Reva D Rajurkar, Nikita H Seth, Nishigandha P Deodhe, Neha Arya
A stroke is a medical emergency that requires rapid treatment. Early intervention can help prevent brain damage and other negative consequences. An ischemic stroke occurs when a blood clot blocks or narrows a blood artery leading to the brain. Systemic lupus erythematosus (SLE) is characterized by systemic inflammation, autoantibodies, and a relapsing-remitting illness. Patients with SLE have an increased cumulative risk of cardiovascular events, including stroke, especially in the first five years after diagnosis...
February 2024: Curēus
#18
REVIEW
Valeria Guglielmi, Marta Cheli, Paola Tonin, Gaetano Vattemi
Sporadic inclusion body myositis (sIBM) is the most common muscle disease of older people and is clinically characterized by slowly progressive asymmetrical muscle weakness, predominantly affecting the quadriceps, deep finger flexors, and foot extensors. At present, there are no enduring treatments for this relentless disease that eventually leads to severe disability and wheelchair dependency. Although sIBM is considered a rare muscle disorder, its prevalence is certainly higher as the disease is often undiagnosed or misdiagnosed...
February 27, 2024: International Journal of Molecular Sciences
#19
JOURNAL ARTICLE
Anne Mehnert, Sivan Bershan, Jil Kollmus-Heege, Lea Gerischer, Meret Luise Herdick, Sarah Hoffmann, Sophie Lehnerer, Franziska Scheibe, Frauke Stascheit, Maike Stein, Alastair M Buchan, Andreas Meisel, Annette Aigner, Philipp Mergenthaler
BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease characterized by fatigable weakness of the voluntary muscles and can exacerbate to life-threatening myasthenic crisis (MC), requiring intensive care treatment. Routine laboratory parameters are a cost-effective and widely available method for estimating the clinical outcomes of several diseases, but so far, such parameters have not been established to detect disease progression in MG. METHODS: We conducted a retrospective analysis of selected laboratory parameters related to inflammation and hemogram for MG patients with MC compared to MG patients without MC...
2024: Frontiers in Neurology
#20
REVIEW
Emily Shorter, Viktor Engman, Johanna T Lanner
Skeletal muscle weakness is a debilitating consequence of many malignancies. Muscle weakness has a negative impact on both patient wellbeing and outcome in a range of cancer types and can be the result of loss of muscle mass (i.e. muscle atrophy, cachexia) and occur independently of muscle atrophy or cachexia. There are multiple cancer specific triggers that can initiate the progression of muscle weakness, including the malignancy itself and the tumour environment, as well as chemotherapy, radiotherapy and malnutrition...
March 7, 2024: Molecular Aspects of Medicine
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