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https://www.readbyqxmd.com/read/27854256/natural-deep-eutectic-solvents-nades-as-a-tool-for-bioavailability-improvement-pharmacokinetics-of-rutin-dissolved-in-proline-glycine-after-oral-administration-in-rats-possible-application-in-nutraceuticals
#1
Marta Faggian, Stefania Sut, Beatrice Perissutti, Valeria Baldan, Iztok Grabnar, Stefano Dall'Acqua
There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical products regarding the use of more eco-sustainable solvents for their extraction. Furthermore, the poor oral bioavailability of several phytochemicals with health promoting effects stimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents (NADES) are formed by natural compounds, and can be considered as future solvents being especially useful for the preparation of nutraceuticals and food-grade extracts...
November 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27388899/adherence-to-ketoacids-essential-amino-acids-supplemented-low-protein-diets-and-new-indications-for-patients-with-chronic-kidney-disease
#2
REVIEW
Denis Fouque, Jing Chen, Wei Chen, Liliana Garneata, S J Hwang, Kamyar Kalantar-Zadeh, Joel D Kopple, William E Mitch, Giorgina Piccoli, Vladimir Teplan, Philippe Chauveau
BACKGROUND: Low protein diets (LPD) have long been prescribed to chronic kidney disease patients with the goals of improving metabolic abnormalities and postpone the start of maintenance dialysis. METHODS: We reviewed the recent literature addressing low protein diets supplemented with ketoacids/essential aminoacids prescribed during chronic kidney disease and their effects on metabolic, nutritional and renal parameters since 2013. RESULTS: We show new information on how to improve adherence to these diets, on metabolic improvement and delay of the dialysis needs, and preliminary data in chronic kidney disease associated pregnancy...
July 7, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27383313/very-low-calorie-ketogenic-diet-with-aminoacid-supplement-versus-very-low-restricted-calorie-diet-for-preserving-muscle-mass-during-weight-loss-a-pilot-double-blind-study
#3
G Merra, R Miranda, S Barrucco, P Gualtieri, M Mazza, E Moriconi, M Marchetti, T F M Chang, A De Lorenzo, L Di Renzo
OBJECTIVE: Obesity plays a relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional and metabolic factors. We conducted a dietary intervention case-control randomized trial, to compare the effectiveness on body composition of two nutritional protocols: a very-low-carbohydrate ketogenic diet (VLCKD), integrated by an aminoacid supplement with whey protein, and very low restricted-calorie diet (VLCD). PATIENTS AND METHODS: The clinical study was conducted with a randomized case-control in which twenty-five healthy subjects gave informed consent to participate in the interventional study and were evaluated for their health and nutritional status, by anthropometric, and body composition evaluation...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26989644/insulin-driven-translational-capacity-is-impaired-in-primary-fibroblasts-of-prader-willi
#4
Cristiana Meneghello, Daniela Segat, Elisabetta Fortunati
Prader-Willi (PW) syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities and severe hypotonia, hyperphagia, behavioural and psychiatric problems. Absence of satiety leads to severe obesity and frequently to diabetes. Furthermore, adult patients suffer from a severe loss of muscle mass, which severely impacts their quality of life. The mechanisms underlying alterations in muscle growth in PW remain to be clarified. In this study we explored the hypothesis that, in PW cells, alterations of protein synthesis are determined by dysfunctions in the promotion of cell growth...
February 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/26986929/toxicity-of-canavanine-in-tomato-solanum-lycopersicum-l-roots-is-due-to-alterations-in-rns-ros-and-auxin-levels
#5
Urszula Krasuska, Olga Andrzejczak, Paweł Staszek, Wojciech Borucki, Agnieszka Gniazdowska
Canavanine (CAN) is non-proteinogenic aminoacid and a structural analog of arginine (Arg). Naturally, CAN occurs in legumes e.g. jack bean and is considered as a strong allelochemical. As a selective inhibitor of inducible nitric oxide synthase in mammalians, it could act as a modifier of nitric oxide (NO) concentration in plants. Modifications in the content of endogenous reactive nitrogen species (RNS) and reactive oxygen species (ROS) influence root structure and architecture, being also under hormonal control...
June 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/25875125/the-pharmacological-and-non-pharmacological-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-protocol-for-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Alain D Mayhew, Matthew J Page, Manuel Ridao, Aurelio Tobías, Miguel A Catalá, Rafael Tabarés-Seisdedos, David Moher
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD. METHODS: Searches involving PubMed/MEDLINE and the Cochrane Database of Systematic Reviews will be used to identify related systematic reviews and relevant randomized trials...
February 27, 2015: Systematic Reviews
https://www.readbyqxmd.com/read/25519493/selenium-an-element-for-life
#7
REVIEW
Leonidas H Duntas, Salvatore Benvenga
This review aims to illustrate the importance of selenium (Se) for maintenance of overall health, especially for the thyroid, immunity, and homeostasis. Furthermore, it outlines the role of Se in reproduction and in virology and discusses the effects of Se supplementation in critical illness. The multifaceted aspects of this essential nutrient have attracted worldwide clinical and research interest in the last few decades. Se exerts its activity in the form of the aminoacid selenocysteine incorporated in selenoproteins...
April 2015: Endocrine
https://www.readbyqxmd.com/read/25246343/the-effectiveness-of-oral-essential-aminoacids-and-aminoacids-containing-dialysate-in-peritoneal-dialysis
#8
Selman Unverdi, Mevlut Ceri, Ebru Uz, Bulent Akgul, Mustafa Altay, Yasemin Kirac, Ali Akcay, Murat Duranay
BACKGROUND/AIM: Oral essential amino acids (AAs) containing supplements (EAS) and AA containing dialysate (ACD) are frequently used in peritoneal dialysis (PD) patients with malnutrition. The present study was conducted to investigate two strategies and compare their effects on the malnutrition status of PD patients. MATERIALS AND METHODS: A total of 31 EAS, 14 ACD patients were enrolled in this study. Serum albumin levels were lower than 3.5 g/dL in all subjects...
October 2014: Renal Failure
https://www.readbyqxmd.com/read/25113619/protein-modification-as-oxidative-stress-marker-in-follicular-fluid-from-women-with-polycystic-ovary-syndrome-the-effect-of-inositol-and-metformin
#9
P Piomboni, R Focarelli, A Capaldo, A Stendardi, V Cappelli, A Cianci, A La Marca, A Luddi, V De Leo
PURPOSE: The purpose of this study was to evaluate the oxidative stress status (OS) of follicular fluid (FF) and the oocyte quality in women with polycystic ovary syndrome (PCOS) undergoing different ovarian stimulation protocols. METHODS: FF samples were collected after gonadotropin administration in association or not with metformin or D-chiro-inositol (DCI). OS status was then evaluated by checking the follicular fluid protein oxidation profile after specific labeling of aminoacidic free-SH groups, and two-dimensional electrophoresis followed by qualitative and semiquantitative analysis...
October 2014: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/24844176/nutritional-treatment-for-acute-and-chronic-traumatic-brain-injury-patients
#10
REVIEW
L Curtis, P Epstein
Proper nutrition is critical for recovery from traumatic brain injury (TBI). Prompt enteral feeding of moderate to severe TBI patients has been associated with significantly lower mortality and rates of infection. Probiotic supplementation has been associated with significantly lower rates of infection in TBI and other trauma patients. Human studies have suggested that supplementation with omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, and zinc may be helpful for recovery from TBI. Animal TBI models have suggested that alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients (such as resveratrol) are also helpful...
September 2014: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/24665660/-renal-risks-of-dietary-complements-a-forgotten-cause
#11
REVIEW
Olympia Dori, Antoine Humbert, Michel Burnier, Daniel Teta
The use of dietary complements like vitamins, minerals, trace elements, proteins, aminoacids and plant-derived agents is prevalent in the general population, in order to promote health and treat diseases. Dietary complements are considered as safe natural products and are easily available without prescription. However, these can lead to severe renal toxicity, especially in cases of unknown pre-existing chronic kidney disease (CKD). In particular, Chinese herbs including aristolochic acid, high doses of vitamine C, creatine and protein complements may lead to acute and chronic renal failure, sometimes irreversible...
February 26, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/24594175/exploitation-of-starch-industry-liquid-by-product-to-produce-bioactive-peptides-from-rice-hydrolyzed-proteins
#12
Lucilla Dei Piu', Annalisa Tassoni, Diana Isabella Serrazanetti, Maura Ferri, Elena Babini, Davide Tagliazucchi, Andrea Gianotti
Small peptides show higher antioxidant capacity than native proteins and may be absorbed in the intestine without further digestion. In our study, a protein by-product from rice starch industry was hydrolyzed with commercial proteolytic enzymes (Alcalase, Neutrase, Flavourzyme) and microbial whole cells of Bacillus spp. and the released peptides were tested for antioxidant activity. Among enzymes, Alcalase was the most performing, while microbial proteolytic activity was less efficient. Conversely, the antioxidant activity was higher in the samples obtained by microbial hydrolysis and particularly with Bacillus pumilus AG1...
July 15, 2014: Food Chemistry
https://www.readbyqxmd.com/read/24281261/advances-in-drug-design-based-on-the-amino-acid-approach-taurine-analogues-for-the-treatment-of-cns-diseases
#13
Man Chin Chung, Pedro Malatesta, Priscila Longhin Bosquesi, Paulo Renato Yamasaki, Jean Leandro Dos Santos, Ednir Oliveira Vizioli
Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the amino acid taurine (2-aminoethanesulfonic acid) this is not true. Due its special physicochemical properties, taurine is unable to cross the blood-brain barrier. In addition of injured taurine transport systems under pathological conditions, CNS supplementation of taurine is almost null. Taurine is a potent antioxidant and anti-inflammatory semi-essential amino acid extensively involved in neurological activities, acting as neurotrophic factor, binding to GABA A/glycine receptors and blocking the excitotoxicity glutamate-induced pathway leading to be a neuroprotective effect and neuromodulation...
2012: Pharmaceuticals
https://www.readbyqxmd.com/read/24264355/detection-of-sulphur-dioxide-in-the-air-using-scotch-pine-needles
#14
K M Nyomárkay, F Lorand, S János
Air quality is especially important in surface layers, for it is this layer that provides the living components of environment with the needed oxygen and carbon dioxide. Various air polluting gases penetrate cells affecting and contaminating them. Chloroplast shell of some pine species, for instance, doubles under the impact of carbon dioxide which is followed by tillacoids swelling and reduction.Literature provides opinions of some authors, who consider Scotch pine needle to be a biological indicator of sulphur dioxide...
December 1982: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/23999674/effect-of-two-different-doses-of-parenteral-amino-acid-supplementation-on-postnatal-growth-of-very-low-birth-weight-neonates-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Haribalakrishna Balasubramanian, Ruchi N Nanavati, Nandkishor S Kabra
OBJECTIVE: To evaluate the effects of two different doses of parenteral aminoacid supplementation on postnatal growth in Very Low Birth Weight (VLBW) infants receiving partial parenteral nutrition (PPN). DESIGN: Double blinded randomized controlled trial. SETTING: Level 3 NICU between February 2008 to February 2010. PARTICIPANTS: 150 inborn babies with birthweight between 900-1250 g, irrespective of gestational age, were randomized to either of the two interventions of amino acid supplementation...
December 2013: Indian Pediatrics
https://www.readbyqxmd.com/read/23817635/apolipoprotein-e-genotype-may-influence-urinary-gammacarboxyglutamate-gla-concentrations-in-young-individuals
#16
Alexandra M Crăciun, Cees Vermeer
Upon degradation of vitamin K-dependent proteins (known as Gla-proteins) the free aminoacid Gla cannot be re-utilized and is excreted in the urine, where it can be used as an overall marker for vitamin K status. We report the urinary Gla excretion values in first morning void urine for healthy young Romanian subjects from birth, childhood and young adulthood. In these subjects we have evaluated age, gender and apo E genotype as potential confounders. The urinary free Gla/creat ratio (Gla/creat, mg/g) was highest in newborns (34...
September 2013: General Physiology and Biophysics
https://www.readbyqxmd.com/read/23478190/dihydrolipoamide-dehydrogenase-deficiency-a-still-overlooked-cause-of-recurrent-acute-liver-failure-and-reye-like-syndrome
#17
Anaïs Brassier, Chris Ottolenghi, Audrey Boutron, Anne-Marie Bertrand, Séverine Valmary-Degano, Jean-Paul Cervoni, Dominique Chrétien, Jean-Baptiste Arnoux, Laurence Hubert, Daniel Rabier, Florence Lacaille, Yves de Keyzer, Vincent Di Martino, Pascale de Lonlay
The causes of Reye-like syndrome are not completely understood. Dihydrolipoamide dehydrogenase (DLD or E3) deficiency is a rare metabolic disorder causing neurological or liver impairment. Specific changes in the levels of urinary and plasma metabolites are the hallmark of the classical form of the disease. Here, we report a consanguineous family of Algerian origin with DLD deficiency presenting without suggestive clinical laboratory and anatomopathological findings. Two children died at birth from hepatic failure and three currently adult siblings had recurrent episodes of hepatic cytolysis associated with liver failure or Reye-like syndrome from infancy...
May 2013: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/23465886/protective-effects-of-l-glutamine-on-the-bladder-wall-of-rats-submitted-to-pelvic-radiation
#18
Leilane M Barcellos, Waldemar S Costa, Jorge L Medeiros, Beatriz R Rocha, Francisco J B Sampaio, Luiz E M Cardoso
Radiotherapy is often used to treat prostate tumors, but the normal bladder is usually adversely affected. Using an animal model of pelvic radiation, we investigated whether glutamine nutritional supplementation can prevent radiation-induced damage to the bladder, especially in its more superficial layers. Male rats aged 3-4 months were divided into groups of 8 animals each: controls, which consisted intact animals; radiated-only rats, which were sacrificed 7 (R7) or 15 (R15) days after a radiation session (10Gy aimed at the pelvico-abdominal region); and radiated rats receiving l-glutamine supplementation (0...
April 2013: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/21880207/beneficial-nutraceutical-modulation-of-cerebral-erythropoietin-expression-and-oxidative-stress-an-experimental-study
#19
S Sedriep, X Xia, F Marotta, L Zhou, H Yadav, H Yang, V Soresi, R Catanzaro, K Zhong, A Polimeni, D H Chui
The main object of this study is to examine the effect of Klamin®, a nutraceutical containing phenylethylamine, phycocyanins, mycosporine-like aminoacids and aphanizomenon flos aquae-phytochrome on the learning and memory ability, the oxidative status and cerebral erythropoietin and its receptor EPO/EPOR system in prematurely senescent (PS) mice. A total of 28 PS mice, selected according to a prior T-maze test, and 26 non-prematurely senescent mice (NPS) mice were chosen. PS animals were divided into 3 groups and followed for 4 weeks: A) normal chow diet; B) added with Klamin® at 20 mg/kg/day (low dose); C) added with Klamin® at 100mg/kg/day (high dose)...
April 2011: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/21769770/hepatoprotective-role-of-neutrosecr-on-hepatic-damage-induced-by-combination-of-zidovudine-and-combined-anti-tuberculous-agents-in-rats
#20
Olufunsho Awodele, Esther O Agbaje, Enitan A Adesina, Alade Akintonwa
BACKGROUND: Advent of the HIV/AIDS pandemic has led to a dramatic increase in the number of TB cases worldwide. Availability of highly active antiretroviral therapy (HAART) has significantly improved the outcome of HIV/AIDS, in terms of prevention of opportunistic infections (OIs) as well as mortality however; liver toxicity is one of the most relevant adverse effects of antiretroviral therapy (ART). PURPOSE: In view of the inevitable use of zidovudine (a common ART) and antituberculous fixed-dose combination therapy (FDCs) in the management of HIV-TB co-infection and the resultant hepatotoxicity, this study was aimed to investigate the hepatoprotective role of neutrosec (a combination of aminoacid and vitamins) on the hepatotoxicity induced by co-administration of zidovudine and combined fixed dose antituberculous agents...
July 2011: Tokai Journal of Experimental and Clinical Medicine
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