keyword
MENU ▼
Read by QxMD icon Read
search

Magnetic resonance alzheimer

keyword
https://www.readbyqxmd.com/read/29458036/plasma-amyloid-levels-within-the-alzheimer-s-process-and-correlations-with-central-biomarkers
#1
Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, Jean-Marc Tréluyer, Patrick Gelé, Christine Delmaire, Fredéric Blanc, Jean-François Mangin, Luc Buée, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elèna Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe-Henri Robert, Olivier Godefroy, Thierry Dantoine, Vincent Camus, Joël Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Suzanna Schraen-Maschke, Audrey Gabelle
BACKGROUNDS: Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. OBJECTIVES: To assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers. METHODS: One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included...
February 16, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29454154/age-related-functional-changes-in-domain-specific-medial-temporal-lobe-pathways
#2
David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düzel
There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29439322/cerebrospinal-fluid-biomarkers-are-differentially-related-to-structural-and-functional-changes-in-dementia-of-the-alzheimer-s-type
#3
Charles B Malpas, Michael M Saling, Dennis Velakoulis, Patricia Desmond, Rodney J Hicks, Henrik Zetterberg, Kaj Blennow, Terence J O'Brien
The two cardinal pathologies of Alzheimer's disease (AD) develop according to distinct anatomical trajectories. Cerebral tau-related pathology first accumulates in the mesial temporal region, while amyloid-related pathology first appears in neocortex. The eventual distributions of these pathologies reflect their anatomical origins. An implication is that the cardinal pathologies might exert preferential effects on the structurofunctional brain changes observed in AD. We investigated this hypothesis in 39 patients with dementia of the Alzheimer's type...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29434324/the-utility-of-a-network-based-clustering-method-for-dimension-reduction-of-imaging-and-non-imaging-biomarkers-predictive-of-alzheimer-s-disease
#4
Hisako Yoshida, Atsushi Kawaguchi, Fumio Yamashita, Kazuhiko Tsuruya
While the identification of biomarkers for Alzheimer's disease (AD) is critical, emphasis must also be placed on defining the relationship between these and other indicators. To this end, we propose a network-based radial basis function-sparse partial least squares (RBF-sPLS) approach to analyze structural magnetic resonance imaging (sMRI) data of the brain. This intermediate phenotype for AD represents a more objective approach for exploring biomarkers in the blood and cerebrospinal fluid. The proposed method has two unique features for effective biomarker selection...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422088/associations-of-bcl-2-rs956572-genotype-groups-in-the-structural-covariance-network-in-early-stage-alzheimer-s-disease
#5
Chiung-Chih Chang, Ya-Ting Chang, Chi-Wei Huang, Shih-Jen Tsai, Shih-Wei Hsu, Shu-Hua Huang, Chen-Chang Lee, Wen-Neng Chang, Chun-Chung Lui, Chia-Yi Lien
BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemia/lymphoma-2 (Bcl-2) gene, rs956572, has been found to significantly modulate Bcl-2 protein expression in the brain. The Bcl-2 AA genotype has been associated with reduced Bcl-2 levels and lower gray matter volume in healthy populations. We hypothesized that different Bcl-2 genotype groups may modulate large-scale brain networks that determine neurobehavioral test scores...
February 8, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29419480/comparative-in-vitro-and-in-vivo-quantifications-of-pathological-tau-deposits-and-their-association-with-neurodegeneration-in-tauopathy-mouse-models
#6
Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuchi
Fibrillary tau aggregates in Alzheimer's disease (AD) and allied neurodegenerative disorders have been visualized in-vivo by positron emission tomography (PET), while mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate associations between PET and postmortem measures of tau probe binding and their relation to neuronal loss. Methods: PET with a tau probe, 11C-PBB3 (2-((1E,3E)-4-(6-(11C-methylamino)pyridine-3-yl)buta-1,3-dienyl)benzo[d]thiazol-6-ol), and volumetric magnetic resonance imaging (MRI) were performed for rTg4510 and non-transgenic mice...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29415770/early-brain-connectivity-alterations-and-cognitive-impairment-in-a-rat-model-of-alzheimer-s-disease
#7
Emma Muñoz-Moreno, Raúl Tudela, Xavier López-Gil, Guadalupe Soria
BACKGROUND: Animal models of Alzheimer's disease (AD) are essential to understanding the disease progression and to development of early biomarkers. Because AD has been described as a disconnection syndrome, magnetic resonance imaging (MRI)-based connectomics provides a highly translational approach to characterizing the disruption in connectivity associated with the disease. In this study, a transgenic rat model of AD (TgF344-AD) was analyzed to describe both cognitive performance and brain connectivity at an early stage (5 months of age) before a significant concentration of β-amyloid plaques is present...
February 7, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29415768/design-and-first-baseline-data-of-the-dzne-multicenter-observational-study-on-predementia-alzheimer-s-disease-delcode
#8
Frank Jessen, Annika Spottke, Henning Boecker, Frederic Brosseron, Katharina Buerger, Cihan Catak, Klaus Fliessbach, Christiana Franke, Manuel Fuentes, Michael T Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Felix Menne, Peter Nestor, Oliver Peters, Josef Priller, Verena Pross, Alfredo Ramirez, Anja Schneider, Oliver Speck, Eike Jakob Spruth, Stefan Teipel, Ruth Vukovich, Christine Westerteicher, Jens Wiltfang, Steffen Wolfsgruber, Michael Wagner, Emrah Düzel
BACKGROUND: Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer's disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-mild cognitive impairment (pre-MCI) at-risk state of dementia, which emerges as a highly promising target for AD prevention. METHODS: The German Center for Neurodegenerative Diseases (DZNE) is conducting the multicenter DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE), which focuses on the characterization of SCD in patients recruited from memory clinics...
February 7, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29415470/multimodal-discrimination-between-normal-aging-mild-cognitive-impairment-and-alzheimer-s-disease-and-prediction-of-cognitive-decline
#9
Corinna M Bauer, Howard J Cabral, Ronald J Killiany
Alzheimer's Disease (AD) and mild cognitive impairment (MCI) are associated with widespread changes in brain structure and function, as indicated by magnetic resonance imaging (MRI) morphometry and 18-fluorodeoxyglucose position emission tomography (FDG PET) metabolism. Nevertheless, the ability to differentiate between AD, MCI and normal aging groups can be difficult. Thus, the goal of this study was to identify the combination of cerebrospinal fluid (CSF) biomarkers, MRI morphometry, FDG PET metabolism and neuropsychological test scores to that best differentiate between a sample of normal aging subjects and those with MCI and AD from the Alzheimer's Disease Neuroimaging Initiative...
February 6, 2018: Diagnostics
https://www.readbyqxmd.com/read/29410622/serum-hepatocyte-growth-factor-is-associated-with-small-vessel-disease-in-alzheimer-s-dementia
#10
Yanan Zhu, Saima Hilal, Yuek L Chai, M K Ikram, Narayanaswamy Venketasubramanian, Christopher P Chen, Mitchell K P Lai
Background: While hepatocyte growth factor (HGF) is known to exert cell growth, migration and morphogenic effects in various organs, recent studies suggest that HGF may also play a role in synaptic maintenance and cerebrovascular integrity. Although increased levels of HGF have been reported in brain and cerebrospinal fluid (CSF) samples of patients with Alzheimer's disease (AD), it is unclear whether peripheral HGF may be associated with cerebrovascular disease (CeVD) and dementia. In this study, we examined the association of baseline serum HGF with neuroimaging markers of CeVD in a cohort of pre-dementia (cognitive impaired no dementia, CIND) and AD patients...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29410070/the-neuroimaging-basis-of-apathy-empirical-findings-and-conceptual-challenges
#11
Sergio E Starkstein, Simone Brockman
Apathy, usually defined as loss of motivation, is common in both neurodegenerative conditions such as Alzheimer's disease, and acute neurological disorders such as stroke. Neuroradiological studies on the imaging correlates of apathy have used a variety of methods such as structural and functional magnetic resonance imaging, diffusion tensor imaging, and single photon and positron emission tomography to assess brain metabolic activity and specific synaptic receptors. Dysfunction of the anterior cingulate cortex (ACC) is the strongest anatomical correlate of apathy in Alzheimer's disease, whereas lesions of the basal ganglia are the most common correlates of apathy in cerebrovascular disorders...
February 2, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29398961/comparison-of-standardized-uptake-value-ratio-calculations-in-amyloid-positron-emission-tomography-brain-imaging
#12
Karin Knešaurek, Geoffrey Warnock, Lale Kostakoglu, Cyrill Burger
Amyloid positron emission tomography (PET) imaging with florbetapir 18F (18F-AV-45) allows in vivo assessment of cerebral amyloid load and can be used in the evaluation of progression of Alzheimer's disease (AD) and other dementias associated with b-amyloid. However, cortical amyloid deposition can occur in healthy cases, as well as in patients with AD and quantification of cortical amyloid burden can improve the 18F-AV-45 PET imaging evaluations. The quantification is mostly performed by cortical-to-cerebellum standardized uptake value ratio (SUVr)...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29396231/abnormal-of-inter-hemispheric-functional-connectivity-in-elderly-subjects-with-overweight-obesity
#13
Xiao Luo, Kaicheng Li, Y L Jia, Qingze Zeng, Yerfan Jiaerken, Tiantian Qiu, Peiyu Huang, Xiaojun Xu, Minming Zhang
BACKGROUND: There is a growing literature documenting a variety of brain abnormalities associated with obesity. However, little is known about the effects of obesity on inter-hemispheric connectivity in aging people. METHODS: Participants included 61 cognitively intact elderly (including people with obesity, overweight, and lean controls) who underwent structural MRI, resting-state functional magnetic resonance imaging (rsfMRI) and standard neuropsychological batteries...
January 29, 2018: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29387938/post-mortem-inference-of-the-human-hippocampal-connectivity-and-microstructure-using-ultra-high-field-diffusion-mri-at-11-7-t
#14
Justine Beaujoin, Nicola Palomero-Gallagher, Fawzi Boumezbeur, Markus Axer, Jeremy Bernard, Fabrice Poupon, Daniel Schmitz, Jean-François Mangin, Cyril Poupon
The human hippocampus plays a key role in memory management and is one of the first structures affected by Alzheimer's disease. Ultra-high magnetic resonance imaging provides access to its inner structure in vivo. However, gradient limitations on clinical systems hinder access to its inner connectivity and microstructure. A major target of this paper is the demonstration of diffusion MRI potential, using ultra-high field (11.7 T) and strong gradients (750 mT/m), to reveal the extra- and intra-hippocampal connectivity in addition to its microstructure...
January 31, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29383737/quality-evaluation-of-no-reference-mr-images-using-multidirectional-filters-and-image-statistics
#15
Jinseong Jang, Kihun Bang, Hanbyol Jang, Dosik Hwang
PURPOSE: This study aimed to develop a fully automatic, no-reference image-quality assessment (IQA) method for MR images. METHODS: New quality-aware features were obtained by applying multidirectional filters to MR images and examining the feature statistics. A histogram of these features was then fitted to a generalized Gaussian distribution function for which the shape parameters yielded different values depending on the type of distortion in the MR image. Standard feature statistics were established through a training process based on high-quality MR images without distortion...
January 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29382825/ultramicronized-palmitoylethanolamide-rescues-learning-and-memory-impairments-in-a-triple-transgenic-mouse-model-of-alzheimer-s-disease-by-exerting-anti-inflammatory-and-neuroprotective-effects
#16
Caterina Scuderi, Maria Rosanna Bronzuoli, Roberta Facchinetti, Lorenzo Pace, Luca Ferraro, Kevin Donald Broad, Gaetano Serviddio, Francesco Bellanti, Gianmauro Palombelli, Giulia Carpinelli, Rossella Canese, Silvana Gaetani, Luca Steardo, Luca Steardo, Tommaso Cassano
In an aging society, Alzheimer's disease (AD) exerts an increasingly serious health and economic burden. Current treatments provide inadequate symptomatic relief as several distinct pathological processes are thought to underlie the decline of cognitive and neural function seen in AD. This suggests that the efficacy of treatment requires a multitargeted approach. In this context, palmitoylethanolamide (PEA) provides a novel potential adjunct therapy that can be incorporated into a multitargeted treatment strategy...
January 31, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29379287/the-association-between-hippocampal-subfield-volumes-and-education-in-cognitively-normal-older-adults-and-amnestic-mild-cognitive-impairment-patients
#17
Dong Woo Kang, Hyun Kook Lim, Soo-Hyun Joo, Na Rae Lee, Chang Uk Lee
Objective: Previous research has indicated that there are potential associations between education and total hippocampal volume in the trajectory of Alzheimer's disease (AD). However, the correlation between education and hippocampal subfield volumes in the progression of AD has yet to be understood. This study examined the relationship between education, which is a standard proxy for cognitive reserve, and hippocampal subfield volumes in healthy and amnestic mild cognitive impairment (aMCI) groups...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29378223/principles-of-diffusion-kurtosis-imaging-and-its-role-in-early-diagnosis-of-neurodegenerative-disorders
#18
REVIEW
Anas Arab, Anna Wojna-Pelczar, Amit Khairnar, Nikoletta Szabó, Jana Ruda-Kucerova
Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue's microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques...
January 26, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29376870/assay-of-plasma-phosphorylated-tau-protein-threonine-181-and-total-tau-protein-in-early-stage-alzheimer-s-disease
#19
Che-Chuan Yang, Ming-Jang Chiu, Ta-Fu Chen, Hui-Ling Chang, Bing-Hsien Liu, Shieh-Yueh Yang
The feasibility of assaying plasma phosphorylated tau protein (threonine 181), denoted p-tau181, using immunomagnetic reduction (IMR) is explored. The reagent for assaying p-tau181 with IMR was synthesized, and its analytic performances were characterized. Seventy-three subjects were recruited. Each participant was examined with neuropsychological tests, magnetic resonance imaging, and IMR assay for plasma p-tau181. Using commercially available IMR kits, the plasma total tau protein (T-tau) of each subject was assayed...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29372597/differences-in-the-neural-correlates-of-frontal-lobe-tests
#20
Teruyuki Matsuoka, Yuka Kato, Ayu Imai, Hiroshi Fujimoto, Keisuke Shibata, Kaeko Nakamura, Kei Yamada, Jin Narumoto
BACKGROUND: The Executive Interview (EXIT25), the executive clock-drawing task (CLOX1), and the Frontal Assessment Battery (FAB) are used to assess executive function at the bedside. These tests assess distinct psychometric properties. The aim of this study was to examine differences in the neural correlates of the EXIT25, CLOX1, and FAB based on magnetic resonance imaging. METHODS: Fifty-eight subjects (30 with Alzheimer's disease, 10 with mild cognitive impairment, and 18 healthy controls) participated in this study...
January 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
keyword
keyword
44319
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"