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Magnetic resonance alzheimer

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https://www.readbyqxmd.com/read/29028649/-18f-thk5351-pet-imaging-in-patients-with-semantic-variant-primary-progressive-aphasia
#1
Hyon Lee, Seongho Seo, Sang-Yoon Lee, Hye Jin Jeong, Sung-Ho Woo, Kyoung-Min Lee, Yeong-Bae Lee, Kee Hyung Park, Jae-Hyeok Heo, Cindy W Yoon, Jae Myeong Kang, Jaelim Cho, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Duk L Na, Tatsuo Ido, Victor L Villemagne, Young Noh
BACKGROUND: Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and β-amyloid. Recently selective tau tracers for positron emission tomography (PET) have been developed to determine the presence of cerebral tau deposits in vivo. Here, we investigated the topographical distribution of THK5351 in svPPA patients. MATERIALS AND METHODS: Five svPPA patients, 14 Alzheimer's disease patients, and 15 age-matched normal controls underwent [F]-THK5351 PET scans, magnetic resonance imaging, and detailed neuropsychological tests...
October 12, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28991728/screening-for-cognitive-impairment-by-model-assisted-cerebral-blood-flow-estimation
#2
Toni Lassila, Luigi Yuri Di Marco, Micaela Mitolo, Vincenzo Iaia, Giorgio Levedianos, Annalena Venneri, Alejandro F Frangi
OBJECTIVE: Alzheimer's disease (AD) is a progressive and debilitating neurodegenerative disease; a major health concern in the ageing population with an estimated prevalence of 46 million dementia cases worldwide. Early diagnosis is therefore crucial so mitigating treatments can be initiated at an early stage. Cerebral hypoperfusion has been linked with blood-brain barrier dysfunction in the early stages of AD, and screening for chronic cerebral hypoperfusion in individuals has been proposed for improving the early diagnosis of AD...
October 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28987681/the-evans-index-revisited-new-cut-off-levels-for-use-in-radiological-assessment-of-ventricular-enlargement-in-the-elderly
#3
Maiken K Brix, Eric Westman, Andrew Simmons, Geir Andre Ringstad, Per Kristian Eide, Kari Wagner-Larsen, Christian M Page, Valeria Vitelli, Mona K Beyer
BACKGROUND AND PURPOSE: Assessment of ventricular enlargement is subjective and based on the radiologist's experience. Linear indices, such as the Evans Index (EI), have been proposed as markers of ventricular volume with an EI≥0.3 indicating pathologic ventricular enlargement in any subject. However, normal range for EI measured on magnetic resonance imaging (MRI) scans are lacking in healthy elderly according to age and sex. We propose new age and sex specific cut-off values for ventricular enlargement in the elderly population...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28984601/failure-to-recover-from-proactive-semantic-interference-and-abnormal-limbic-connectivity-in-asymptomatic-middle-aged-offspring-of-patients-with-late-onset-alzheimer-s-disease
#4
Stella M Sánchez, Carolina Abulafia, Barbara Duarte-Abritta, M Soledad Ladrón de Guevara, Mariana N Castro, Lucas Drucaroff, Gustavo Sevlever, Charles B Nemeroff, Daniel E Vigo, David A Loewenstein, Mirta F Villarreal, Salvador M Guinjoan
BACKGROUND: We have obtained previous evidence of limbic dysfunction in middle-aged, asymptomatic offspring of late-onset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD. OBJECTIVE: To assess the effects of specific proactive semantic interference deficits as they relate to functional magnetic resonance imaging (fMRI) neocortical and limbic functional connectivity in middle aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28984583/deficit-in-central-auditory-processing-as%C3%A2-a%C3%A2-biomarker-of-pre-clinical-alzheimer-s-disease
#5
Miranda Tuwaig, Mélissa Savard, Benoît Jutras, Judes Poirier, D Louis Collins, Pedro Rosa-Neto, David Fontaine, John C S Breitner
Prevention of dementia due to Alzheimer's disease (d/AD) requires interventions that slow the disease process prior to symptom onset. To develop such interventions, one needs metrics that assess pre-symptomatic disease progression. Familiar measures of progression include cerebrospinal fluid (CSF) biochemical and imaging analyses, as well as cognitive testing. Changes in the latter can sometimes be difficult to distinguish from effects of "normal" aging. A different approach involves testing of "central auditory processing" (CAP), which enables comprehension of auditory stimuli amidst a distracting background (e...
October 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28980608/-neuroimaging-and-molecular-biomarkers-of-dementia
#6
T A Polyakova, A V Arablinsky
Development of laboratory diagnosis and neuroimaging revealed a number of biomarkers for in vivo diagnosis of the most common forms of dementia (Alzheimer's disease, Lewy body dementia and vascular dementia). Currently, the highest diagnostic sensitivity and specificity of molecular biomarkers in the cerebrospinal fluid are detected for Alzheimer's disease. At the same time, the changes according to the magnetic resonance imaging are more prognostically significant for future cognitive decline than cerebrospinal fluid biomarkers...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28979205/atrophy-of-the-posterior-subiculum-is-associated-with-memory-impairment-tau-and-a%C3%AE-pathology-in-non-demented-individuals
#7
Olof Lindberg, Gustav Mårtensson, Erik Stomrud, Sebastian Palmqvist, Lars-Olof Wahlund, Eric Westman, Oskar Hansson
Alzheimer's disease (AD) is associated with atrophy of the cornu ammonis (CA) 1 and the subiculum subfield of the hippocampus (HC), and with deficits in episodic memory and spatial orientation. These deficits are mainly associated with the functionality of the posterior HC. We therefore hypothesized that key AD pathologies, i.e., β-amyloid and tau pathology would be particularly associated with the volume of the posterior subiculum in non-demented individuals. In our study we included 302 cognitively normal elderly participants (CN), 183 patients with subjective cognitive decline (SCD) and 171 patients with amnestic mild cognitive impairment (MCI), all of whom underwent 3T magnetic resonance images (MRI)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28977066/support-vector-machine-based-classification-of-neuroimages-in-alzheimer-s-disease-direct-comparison-of-fdg-pet-rcbf-spect-and-mri-data-acquired-from-the-same-individuals
#8
Luiz K Ferreira, Jane M Rondina, Rodrigo Kubo, Carla R Ono, Claudia C Leite, Jerusa Smid, Cassio Bottino, Ricardo Nitrini, Geraldo F Busatto, Fabio L Duran, Carlos A Buchpiguel
OBJECTIVE: To conduct the first support vector machine (SVM)-based study comparing the diagnostic accuracy of T1-weighted magnetic resonance imaging (T1-MRI), F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and regional cerebral blood flow single-photon emission computed tomography (rCBF-SPECT) in Alzheimer's disease (AD). METHOD: Brain T1-MRI, FDG-PET and rCBF-SPECT scans were acquired from a sample of mild AD patients (n=20) and healthy elderly controls (n=18)...
October 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28971004/short-term-mechanisms-influencing-volumetric-brain-dynamics
#9
REVIEW
Nikki Dieleman, Huiberdina L Koek, Jeroen Hendrikse
With the use of magnetic resonance imaging (MRI) and brain analysis tools, it has become possible to measure brain volume changes up to around 0.5%. Besides long-term brain changes caused by atrophy in aging or neurodegenerative disease, short-term mechanisms that influence brain volume may exist. When we focus on short-term changes of the brain, changes may be either physiological or pathological. As such determining the cause of volumetric dynamics of the brain is essential. Additionally for an accurate interpretation of longitudinal brain volume measures by means of neurodegeneration, knowledge about the short-term changes is needed...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28969570/new-perspectives-of-alzheimer-disease-diagnosis-the-most-popular-and-future-methods
#10
Katarzyna Pietrzak, Kamila Czarnecka, Elżbieta M Ikiciuk-Olasik, Paweł Szymański
As lifespan tendency is increasing, age-related diseases are becoming a burden to the society and health care system. Mostly incurable, constitute a subject of researchers' work. In this review the insight into the problem of Alzheimer Disease (AD) diagnostics will be given. The unquestionable diagnosis is possible only during a post-mortem examination. AD is known as one of the forms of dementia and its differentiation from mild cognitive impairments has to be improved. Despite a great diagnostic progress during last decades, medicine still needs more accurate tools for an early detection of this incurable disease...
October 2, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28969373/glymphatic-mri-in-idiopathic-normal-pressure-hydrocephalus
#11
Geir Ringstad, Svein Are Sirirud Vatnehol, Per Kristian Eide
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28968236/decreased-n-acetyl-aspartate-myo-inositol-ratio-in-the-posterior-cingulate-cortex-shown-by-magnetic-resonance-spectroscopy-may-be-one-of-the-risk-markers-of-preclinical-alzheimer-s-disease-a-7-year-follow-up-study
#12
Masaaki Waragai, Masaru Moriya, Takeshi Nojo
Although molecular positron emission tomography imaging of amyloid and tau proteins can facilitate the detection of preclinical Alzheimer's disease (AD) pathology, it is not useful in clinical practice. More practical surrogate markers for preclinical AD would provide valuable tools. Thus, we sought to validate the utility of conventional magnetic resonance spectroscopy (MRS) as a screening method for preclinical AD. A total of 289 older participants who were cognitively normal at baseline were clinically followed up for analysis of MRS metabolites, including N-acetyl aspartate (NAA) and myo-inositol (MI) in the posterior cingulate cortex (PCC) for 7 years...
September 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28965143/changes-in-connectivity-of-the-posterior-default-network-node-during-visual-processing-in-mild-cognitive-impairment-staged-decline-between-normal-aging-and-alzheimer-s-disease
#13
Lenka Krajcovicova, Marek Barton, Nela Elfmarkova-Nemcova, Michal Mikl, Radek Marecek, Irena Rektorova
Visual processing difficulties are often present in Alzheimer's disease (AD), even in its pre-dementia phase (i.e. in mild cognitive impairment, MCI). The default mode network (DMN) modulates the brain connectivity depending on the specific cognitive demand, including visual processes. The aim of the present study was to analyze specific changes in connectivity of the posterior DMN node (i.e. the posterior cingulate cortex and precuneus, PCC/P) associated with visual processing in 17 MCI patients and 15 AD patients as compared to 18 healthy controls (HC) using functional magnetic resonance imaging...
September 30, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28959379/empowering-cortical-thickness-measures-in-clinical-diagnosis-of-alzheimer-s-disease-with-spherical-sparse-coding
#14
Jie Zhang, Yonghui Fan, Qingyang Li, Paul M Thompson, Jieping Ye, Yalin Wang
Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD). Directly using raw cortical thickness measures as features with Support Vector Machine (SVM) for clinical group classification only yields modest results since brain areas are not equally atrophied during AD progression. Therefore, feature reduction is generally required to retain only the most relevant features for the final classification...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28958881/hips-a-new-hippocampus-subfield-segmentation-method
#15
José E Romero, Pierrick Coupé, José V Manjón
The importance of the hippocampus in the study of several neurodegenerative diseases such as Alzheimer's disease makes it a structure of great interest in neuroimaging. However, few segmentation methods have been proposed to measure its subfields due to its complex structure and the lack of high resolution magnetic resonance (MR) data. In this work, we present a new pipeline for automatic hippocampus subfield segmentation using two available hippocampus subfield delineation protocols that can work with both high and standard resolution data...
September 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28950242/nitric-oxide-inhibitory-daphnane-diterpenoids-as-potential-anti-neuroinflammatory-agents-for-ad-from-the-twigs-of-trigonostemon-thyrsoideus
#16
Feng Liu, Xueyuan Yang, Jun Ma, Yuling Yang, Chunfeng Xie, Muhetaer Tuerhong, Da-Qing Jin, Jing Xu, Dongho Lee, Yasushi Ohizumi, Yuanqiang Guo
The extensive pathology studies revealed that Alzheimer's disease (AD) is closely related to neuroinflammation and anti-neuroinflammatory agents may be potentially useful for the treatment of AD. A continuous search for new nitric oxide (NO) inhibitory compounds as anti-neuroinflammatory agents for AD resulted in the isolation of four new (1-4) and eight known (5-12) daphnane diterpenoids from the twigs of Trigonostemon thyrsoideus. Their structures were elucidated on the basis of extensive nuclear magnetic resonance (NMR) spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations...
September 7, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28943414/in-vivo-mri-assessment-of-the-human-locus-coeruleus-along-its-rostrocaudal-extent-in-young-and-older-adults
#17
Matthew J Betts, Arturo Cardenas-Blanco, Martin Kanowski, Frank Jessen, Emrah Düzel
The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). As such, there is considerable interest to develop magnetic resonance imaging (MRI) techniques to assess the integrity of the LC in vivo. The high neuromelanin content of the LC serves as an endogenous contrast for MRI but existing protocols suffer from low spatial resolution along the rostrocaudal axis of the LC rendering it difficult to differentiate its integrity in caudal and rostral portions...
September 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28939709/topography-and-determinants-of-magnetic-resonance-imaging-mri-visible-perivascular-spaces-in-a-large-memory-clinic-cohort
#18
Sara Shams, Juha Martola, Andreas Charidimou, Mykol Larvie, Tobias Granberg, Mana Shams, Maria Kristoffersen-Wiberg, Lars-Olof Wahlund
BACKGROUND: Magnetic resonance imaging-visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid-β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. METHODS AND RESULTS: A total of 1504 patients undergoing memory clinic investigation and an associated brain magnetic resonance imaging scan were included in this cross-sectional study...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28938186/electrochemiluminescence-resonance-energy-transfer-system-between-gnrs-and-ru-bpy-3-2-application-in-magnetic-aptasensor-for-%C3%AE-amyloid
#19
Hong Ke, Haifeng Sha, Yinfang Wang, Weiwei Guo, Xin Zhang, Zhiming Wang, Chusen Huang, Nengqin Jia
Electrochemiluminescent (ECL) assay has gradually drawn increasing interest in the biomedical analysis. This paper proposed a new methodology for ultrasensitive and facile detection of Alzheimer's disease marker β-amyloid (Aβ) by fabricating a sandwich-type ECL sensing platform. Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)3(2+) and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively...
September 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28936280/enhancing-diffusion-mri-measures-by-integrating-grey-and-white-matter-morphometry-with-hyperbolic-wasserstein-distance
#20
Wen Zhang, Jie Shi, Jun Yu, Liang Zhan, Paul M Thompson, Yalin Wang
In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic patients. However, the large scale tensor-valued information and relatively low imaging resolution in diffusion MRI (dMRI) have created huge challenges for analysis...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
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