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https://www.readbyqxmd.com/read/28930562/alzheimer-s-disease-diagnostics-by-a-3d-deeply-supervised-adaptable-convolutional-network
#1
Ehsan Hosseini-Asl, Mohammed Ghazal, Ali Mahmoud, Ali Aslantas, Ahmed M Shalaby, Manual F Casanova, Gregory N Barnes, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
Early diagnosis is playing an important role in preventing progress of the Alzheimer's disease (AD). This paper proposes to improve the prediction of AD with a deep 3D Convolutional Neural Network (3D-CNN), which can show generic features capturing AD biomarkers extracted from brain images, adapt to different domain datasets, and accurately classify subjects with improved fine-tuning method. The 3D-CNN is built upon a convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans for source domain...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28928704/prediction-of-cognitive-decline-from-white-matter-hyperintensity-and-single-photon-emission-computed-tomography-in-alzheimer-s-disease
#2
Ken-Ichi Tabei, Hirotaka Kida, Tetsuo Hosoya, Masayuki Satoh, Hidekazu Tomimoto
BACKGROUND: While several studies support an association of white matter hyperintensity (WMH) volume and regional cerebral blood flow (rCBF) with cognitive decline in Alzheimer's disease (AD), no reports have simultaneously considered the effects of both factors on cognitive decline. OBJECTIVE: The purpose of the present study was to compare WMH volume and rCBF in relation to cognitive function by developing a new software program to fuse magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) data...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28923529/can-mri-water-apparent-diffusion-coefficient-adc-value-discriminate-between-idiopathic-normal-pressure-hydrocephalus-alzheimer-s-disease-and-subcortical-vascular-dementia
#3
Goujon Adrien, Mejdoubi Mehdi, Purcell Yvonne, Banydeen Rishika, Colombani Sylvie, Arrigo Alessandro
No abstract text is available yet for this article.
September 15, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28922157/longer-term-investigation-of-the-value-of-18f-fdg-pet-and-magnetic-resonance-imaging-for-predicting-the-conversion-of-mild-cognitive-impairment-to-alzheimer-s-disease-a-multicenter-study
#4
Yoshitaka Inui, Kengo Ito, Takashi Kato
BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and magnetic resonance imaging (MRI) for predicting conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD) in longer-term is unclear. OBJECTIVE: To evaluate longer-term prediction of MCI to AD conversion using 18F-FDG-PET and MRI in a multicenter study. METHODS: One-hundred and fourteen patients with MCI were followed for 5 years...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922067/conceptual-elaboration-versus-direct-lexical-access-in-wais-similarities-differential-effects-of-white-matter-lesions-and-gray-matter-volumes
#5
Sven-Erik Fernaeus, Åke Hellström
Wechsler Adult Intelligence Scale (WAIS) subscale Similarities have been classified as a test of either verbal comprehension or of inductive reasoning. The reason may be that items divide into two categories. We tested the hypothesis of heterogeneity of items in WAIS-Similarities. Consecutive patients at a memory clinic and healthy controls participated in the study. White-matter hyperintensities (WMHs) and normalized temporal lobe volumes were measured based on Magnetic resonance Imaging (MRI), and tests of verbal memory and attention were used in addition to WAIS-Similarities to collect behavioural data...
September 18, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28919059/rates-of-hippocampal-atrophy-and-presence-of-post-mortem-tdp-43-in-patients-with-alzheimer-s-disease-a-longitudinal-retrospective-study
#6
Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell
BACKGROUND: Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. METHODS: In this longitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012, and who had been recruited into the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging...
September 11, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28916531/diabetes-prediabetes-and-brain-volumes-and-subclinical-cerebrovascular-disease-on-mri-the-atherosclerosis-risk-in-communities-neurocognitive-study-aric-ncs
#7
Andrea L C Schneider, Elizabeth Selvin, A Richey Sharrett, Michael Griswold, Josef Coresh, Clifford R Jack, David Knopman, Thomas Mosley, Rebecca F Gottesman
OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA1c and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH DESIGN AND METHODS: Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011-2013...
September 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28913718/identify-a-shared-neural-circuit-linking-multiple-neuropsychiatric-symptoms-with-alzheimer-s-pathology
#8
Xixi Wang, Ping Ren, Mark Mapstone, Yeates Conwell, Anton P Porsteinsson, John J Foxe, Rajeev D S Raizada, Feng Lin
Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD pathology. Here, we explored the neural circuits of NPS in AD-associated neurodegeneration using multivariate pattern analysis (MVPA) of resting-state functional MRI data. Data from 98 subjects (70 amnestic mild cognitive impairment and 28 AD subjects) were obtained...
September 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28912896/investigation-of-the-safety-of-focused-ultrasound-induced-blood-brain-barrier-opening-in-a-natural-canine-model-of-aging
#9
Meaghan Anne O'Reilly, Ryan Matthew Jones, Edward Barrett, Anthony Schwab, Elizabeth Head, Kullervo Hynynen
Rationale: Ultrasound-mediated opening of the Blood-Brain Barrier(BBB) has shown exciting potential for the treatment of Alzheimer's disease(AD). Studies in transgenic mouse models have shown that this approach can reduce plaque pathology and improve spatial memory. Before clinical translation can occur the safety of the method needs to be tested in a larger brain that allows lower frequencies be used to treat larger tissue volumes, simulating clinical situations. Here we investigate the safety of opening the BBB in half of the brain in a large aged animal model with naturally occurring amyloid deposits...
2017: Theranostics
https://www.readbyqxmd.com/read/28912705/corrigendum-multi-kernel-learning-with-dartel-improves-combined-mri-pet-classification-of-alzheimer-s-disease-in-aibl-data-group-and-individual-analyses
#10
Vahab Youssofzadeh, Bernadette McGuinness, Liam P Maguire, KongFatt Wong-Lin
[This corrects the article on p. 380 in vol. 11, PMID: 28790908.].
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28902409/binswanger-s-disease-biomarkers-in-the-inflammatory-form-of-vascular-cognitive-impairment-and-dementia
#11
REVIEW
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28899429/amyloid-independent-atrophy-patterns-predict-time-to-progression-to-dementia-in-mild-cognitive-impairment
#12
Mara Ten Kate, Frederik Barkhof, Pieter Jelle Visser, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Betty M Tijms
BACKGROUND: Amyloid pathology in subjects with mild cognitive impairment (MCI) is an important risk factor for progression to dementia due to Alzheimer's disease. Predicting the onset of dementia is challenging even in the presence of amyloid, as time to progression varies considerably among patients and depends on the onset of neurodegeneration. Survival analysis can account for variability in time to event, but has not often been applied to MRI measurements beyond singular predefined brain regions such as the hippocampus...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28891447/potential-role-of-neuroimaging-markers-for-early-diagnosis-of-dementia-in-primary-care
#13
Stefan Teipel, Ingo Kilimann, Jochen R Thyrian, Stefan Klöppel, Wolfgang Hoffmann
BACKGROUND: The use of imaging markers for the diagnosis of predementia and early dementia stages of Alzheimer's disease (AD) has widely been explored in research settings and specialized care. The use of these markers in primary care has yet to be established. OBJECTIVE: Summarize current evidence for the usefulness of imaging markers for AD in primary compared to specialized care settings. METHOD: Selective overview of the literature, and pilot data on the use of MRI-based hippocampus and basal forebrain volumetry for the discrimination of AD dementia and mild cognitive impairment (MCI) cases from healthy controls in 58 cases from a primary care cohort and 58 matched cases from a memory clinic's sample...
September 7, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28887599/uptake-of-av-1451-in-meningiomas
#14
Tyler J Bruinsma, Derek R Johnson, Ping Fang, Matthew Senjem, Keith A Josephs, Jennifer L Whitwell, Bradley F Boeve, Mukesh K Pandey, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Melissa Murray, Jonathan Graff-Radford, Christopher G Schwarz, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe
AIM: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer's disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. OBJECTIVE: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging...
September 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28879085/progressive-medial-temporal-lobe-atrophy-during-preclinical-alzheimer-s-disease
#15
Corinne Pettigrew, Anja Soldan, Kelly Sloane, Qing Cai, Jiangxia Wang, Mei-Cheng Wang, Abhay Moghekar, Michael I Miller, Marilyn Albert
This study examined whether longitudinal MRI trajectories in medial temporal lobe (MTL) brain regions differed among groups of cognitively normal individuals defined by their cerebrospinal fluid (CSF) levels when they were first enrolled (N = 207; mean clinical follow-up = 13.3 years (max = 20 years), mean MRI follow-up = 2.4 years (max = 8 years)). We first compared atrophy rates among groups defined by CSF amyloid and phosphorylated-tau (p-tau) vs. CSF amyloid and total tau (t-tau). We also examined whether, in the presence of amyloid or tau/p-tau, the atrophy rates differed based on whether the subjects ultimately progressed to a diagnosis of mild cognitive impairment (MCI), as well as whether apolipoprotein ε4 (Apoε4) status had an impact on the longitudinal MRI trajectories...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28879083/monitoring-disease-progression-in-mild-cognitive-impairment-associations-between-atrophy-patterns-cognition-apoe-and-amyloid
#16
Farshad Falahati, Daniel Ferreira, J-Sebastian Muehlboeck, Maria Eriksdotter, Andrew Simmons, Lars-Olof Wahlund, Eric Westman
BACKGROUND: A disease severity index (SI) for Alzheimer's disease (AD) has been proposed that summarizes MRI-derived structural measures into a single score using multivariate data analysis. OBJECTIVES: To longitudinally evaluate the use of the SI to monitor disease progression and predict future progression to AD in mild cognitive impairment (MCI). Further, to investigate the association between longitudinal change in the SI and cognitive impairment, Apolipoprotein E (APOE) genotype as well as the levels of cerebrospinal fluid amyloid-beta 1-42 (Aβ) peptide...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28878053/subjective-memory-complaints-in-preclinical-autosomal-dominant-alzheimer-disease
#17
Daniel J Norton, Rebecca Amariglio, Hillary Protas, Kewei Chen, Daniel C Aguirre-Acevedo, Brendan Pulsifer, Gabriel Castrillon, Victoria Tirado, Claudia Munoz, Pierre Tariot, Jessica B Langbaum, Eric M Reiman, Francisco Lopera, Reisa A Sperling, Yakeel T Quiroz
OBJECTIVE: To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD). METHODS: We examined self-reported and study partner-based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD. Twenty-six carried the PSEN-1 E280A mutation, averaging 7 years of age younger than the kindred's expected clinical onset. Twenty-six were age-matched noncarriers. Participants also underwent structural MRI and cognitive testing...
September 6, 2017: Neurology
https://www.readbyqxmd.com/read/28869470/the-cerebrospinal-fluid-a%C3%AE-1-42-a%C3%AE-1-40-ratio-improves-concordance-with-amyloid-pet-for-diagnosing-alzheimer-s-disease-in-a-clinical-setting
#18
Ellis Niemantsverdriet, Julie Ottoy, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Jeroen Verhaeghe, Tobi Van den Bossche, Sara Van Mossevelde, Johan Goeman, Peter Paul De Deyn, Peter Mariën, Jan Versijpt, Kristel Sleegers, Christine Van Broeckhoven, Leonie Wyffels, Adrien Albert, Sarah Ceyssens, Sigrid Stroobants, Steven Staelens, Maria Bjerke, Sebastiaan Engelborghs
BACKGROUND: Evidence suggests that the concordance between amyloid-PET and cerebrospinal fluid (CSF) amyloid-β (Aβ) increases when the CSF Aβ1-42/Aβ1-40 ratio is used as compared to CSF Aβ1-42 levels alone. OBJECTIVE: In order to test this hypothesis, we set up a prospective longitudinal study comparing the concordance between different amyloid biomarkers for Alzheimer's disease (AD) in a clinical setting. METHODS: Seventy-eight subjects (AD dementia (n = 17), mild cognitive impairment (MCI, n = 48), and cognitively healthy controls (n = 13)) underwent a [18F]Florbetapir ([18F]AV45) PET scan, [18F]FDG PET scan, MRI scan, and an extensive neuropsychological examination...
September 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28860449/reduced-age-associated-brain-changes-in-expert-meditators-a-multimodal-neuroimaging-pilot-study
#19
Gaël Chételat, Florence Mézenge, Clémence Tomadesso, Brigitte Landeau, Eider Arenaza-Urquijo, Géraldine Rauchs, Claire André, Robin de Flores, Stéphanie Egret, Julie Gonneaud, Géraldine Poisnel, Anne Chocat, Anne Quillard, Béatrice Desgranges, Jean-Gérard Bloch, Matthieu Ricard, Antoine Lutz
Aging is associated with progressive cerebral volume and glucose metabolism decreases. Conditions such as stress and sleep difficulties exacerbate these changes and are risk factors for Alzheimer's disease. Meditation practice, aiming towards stress reduction and emotion regulation, can downregulate these adverse factors. In this pilot study, we explored the possibility that lifelong meditation practice might reduce age-related brain changes by comparing structural MRI and FDG-PET data in 6 elderly expert meditators versus 67 elderly controls...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859851/association-of-imaging-abnormalities-of-the-subcallosal-septal-area-with-alzheimer-s-disease-and-mild-cognitive-impairment
#20
C L Gan, M J O'Sullivan, C Metzler-Baddeley, S Halpin
AIM: To evaluate the use the distance between the adjacent septal nuclei as a surrogate marker of septal area atrophy seen in Alzheimer's disease (AD). MATERIALS & METHODS: Interseptal distance (ISD) was measured, blind to clinical details, in 250 patients who underwent computed tomography (CT) of the brain at University Hospital of Wales. Clinical details including memory problem history were retrieved. An ISD cut-off value that discriminated those with and without memory symptoms was sought...
August 30, 2017: Clinical Radiology
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