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Neurovascular coupling

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https://www.readbyqxmd.com/read/29328980/consequence-of-intraventricular-hemorrhage-on-neurovascular-coupling-evoked-by-speech-syllables-in-preterm-neonates
#1
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Guy Kongolo, Marc Fournier, Sabrina Goudjil, Fabrice Wallois
Intraventricular Hemorrhage (IVH) is the leading cause of neurological and cognitive impairment in preterm neonates with an incidence that increases with increasing prematurity. In the present study, we tested how preterm neonates with IVH react to external stimulation (i.e. speech syllables). We compared their neural responses measured by electroencephalography (EEG), and hemodynamic responses measured by functional near-infrared spectroscopy (fNIRS), with those of healthy preterms. A neural response to syllables was observed in these infants, but did not induce a vascular response in contrast with healthy neonates...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29320772/a-perfect-storm-the-role-of-the-mammalian-target-of-rapamycin-mtor-in-cerebrovascular-dysfunction-of-alzheimer-s-disease-a-mini-review
#2
Candice E Van Skike, Veronica Galvan
Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function...
January 11, 2018: Gerontology
https://www.readbyqxmd.com/read/29306934/gliotransmitters-and-cytokines-in-the-control-of-blood-brain-barrier-permeability
#3
REVIEW
Elena D Osipova, Oxana V Semyachkina-Glushkovskaya, Andrey V Morgun, Natalia V Pisareva, Natalia A Malinovskaya, Elizaveta B Boitsova, Elena A Pozhilenkova, Olga A Belova, Vladimir V Salmin, Tatiana E Taranushenko, Mami Noda, Alla B Salmina
The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions...
January 8, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29296629/alterations-in-neurovascular-coupling-following-acute-traumatic-brain-injury
#4
Hyounguk Jang, Stanley Huang, Daniel X Hammer, Lin Wang, Harmain Rafi, Meijun Ye, Cristin G Welle, Jonathan A N Fisher
Following acute traumatic brain injury (TBI), timely transport to a hospital can significantly improve the prognosis for recovery. There is, however, a dearth of quantitative biomarkers for brain injury that can be rapidly acquired and interpreted in active, field environments in which TBIs are frequently incurred. We explored potential functional indicators for TBI that can be noninvasively obtained through portable detection modalities, namely optical and electrophysiological approaches. By combining diffuse correlation spectroscopy with colocalized electrophysiological measurements in a mouse model of TBI, we observed concomitant alterations in sensory-evoked cerebral blood flow (CBF) and electrical potentials following controlled cortical impact...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/29259544/dichotomous-effects-of-mu-opioid-receptor-activation-on-striatal-low-threshold-spike-interneurons
#5
Rasha Elghaba, Enrico Bracci
Striatal low-threshold spike interneurons (LTSIs) are tonically active neurons that express GABA and nitric oxide synthase and are involved in information processing as well as neurovascular coupling. While mu opioid receptors (MORs) and their ligand encephalin are prominent in the striatum, their action on LTSIs has not been investigated. We addressed this issue carrying out whole-cell recordings in transgenic mice in which the NPY-expressing neurons are marked with green fluorescent protein (GFP). The MOR agonist (D-Ala(2), N-MePhe(4), Gly-ol)-enkephalin (DAMGO) produced dual effects on subpopulations of LTSIs...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29247493/the-yin-and-yang-of-kv-channels-in-cerebral-small-vessel-pathologies
#6
Masayo Koide, Arash Moshkforoush, Nikolaos M Tsoukias, David C Hill-Eubanks, George C Wellman, Mark T Nelson, Fabrice Dabertrand
Cerebral small vessel diseases (SVDs) encompass a group of genetic and sporadic pathological processes leading to brain lesions, cognitive decline, and stroke. There is no specific treatment for SVDs, which progress silently for years before becoming clinically symptomatic. Here, we examine parallels in the functional defects of parenchymal arterioles in CADASIL, a monogenic form of SVD, and in response to subarachnoid hemorrhage, a common type of hemorrhagic stroke that also targets the brain microvasculature...
December 15, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29243191/pharmacologically-induced-impairment-of-neurovascular-coupling-responses-alters-gait-coordination-in-mice
#7
Stefano Tarantini, Andriy Yabluchanksiy, Gábor A Fülöp, Peter Hertelendy, M Noa Valcarcel-Ares, Tamas Kiss, Jonathan M Bagwell, Daniel O'Connor, Eszter Farkas, Farzaneh Sorond, Anna Csiszar, Zoltan Ungvari
There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-and-effect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC...
December 14, 2017: GeroScience
https://www.readbyqxmd.com/read/29230054/single-cell-analysis-of-experience-dependent-transcriptomic-states-in-the-mouse-visual-cortex
#8
Sinisa Hrvatin, Daniel R Hochbaum, M Aurel Nagy, Marcelo Cicconet, Keiramarie Robertson, Lucas Cheadle, Rapolas Zilionis, Alex Ratner, Rebeca Borges-Monroy, Allon M Klein, Bernardo L Sabatini, Michael E Greenberg
Activity-dependent transcriptional responses shape cortical function. However, a comprehensive understanding of the diversity of these responses across the full range of cortical cell types, and how these changes contribute to neuronal plasticity and disease, is lacking. To investigate the breadth of transcriptional changes that occur across cell types in the mouse visual cortex after exposure to light, we applied high-throughput single-cell RNA sequencing. We identified significant and divergent transcriptional responses to stimulation in each of the 30 cell types characterized, thus revealing 611 stimulus-responsive genes...
December 11, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#9
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29187557/the-assessment-of-neurovascular-coupling-with-the-addenbrooke-s-cognitive-examination-a-functional-transcranial-doppler-ultrasonographic-study
#10
Lucy C Beishon, Claire A L Williams, Ronney B Panerai, Thompson G Robinson, Victoria Joanna Haunton
Cerebrovascular dysfunction occurs early in dementia and can be identified by Transcranial Doppler ultrasonography (TCD). Few studies have examined cerebral blood flow velocity (CBFv) responses to a detailed cognitive battery. This study aimed to characterise all CBFv responses, and the effect of hemispheric dominance, to the Addenbrooke's Cognitive Examination (ACE-III) in healthy volunteers. Forty volunteers underwent continuous bilateral TCD, beat-to-beat blood pressure (MAP) (Finapres), heart rate (HR) (electrocardiogram), and end-tidal CO2 (ETCO2) (capnography) monitoring...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29184204/weak-correlations-between-hemodynamic-signals-and-ongoing-neural-activity-during-the-resting-state
#11
Aaron T Winder, Christina Echagarruga, Qingguang Zhang, Patrick J Drew
Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29152668/the-role-of-astrocytic-calcium-and-trpv4-channels-in-neurovascular-coupling
#12
Allanah Kenny, Michael J Plank, Tim David
Neuronal activity evokes a localised change in cerebral blood flow in a response known as neurovascular coupling (NVC). Although NVC has been widely studied the exact mechanisms that mediate this response remain unclear; in particular the role of astrocytic calcium is controversial. Mathematical modelling can be a useful tool for investigating the contribution of various signalling pathways towards NVC and for analysing the underlying cellular mechanisms. The lumped parameter model of a neurovascular unit with both potassium and nitric oxide (NO) signalling pathways and comprised of neurons, astrocytes, and vascular cells has been extended to include the glutamate induced astrocytic calcium pathway with epoxyeicosatrienoic acid (EET) signalling and the stretch dependent TRPV4 calcium channel on the astrocytic endfoot...
November 20, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29133510/single-cell-immuno-laser-microdissection-coupled-to-label-free-proteomics-to-reveal-the-proteotypes-of-human-brain-cells-after-ischemia
#13
Teresa García-Berrocoso, Víctor Llombart, Laura Colàs-Campàs, Alexandre Hainard, Virginie Licker, Anna Penalba, Laura Ramiro, Alba Simats, Alejandro Bustamante, Elena Martínez-Saez, Francesc Canals, Jean-Charles Sanchez, Joan Montaner
Cerebral ischemia entails rapid tissue damage in the affected brain area causing devastating neurological dysfunction. How each component of the neurovascular unit contributes or responds to the ischemic insult in the context of the human brain has not been solved yet. Thus, the analysis of the proteome is a straightforward approach to unraveling these cell proteotypes.In this study, post-mortem brain slices from ischemic stroke patients were obtained corresponding to infarcted (IC) and contralateral (CL) areas...
November 13, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29131981/disturbances-in-the-control-of-capillary-flow-in-an-aged-app-swe-ps1%C3%AE-e9-model-of-alzheimer-s-disease
#14
Eugenio Gutiérrez-Jiménez, Hugo Angleys, Peter M Rasmussen, Mark J West, Laura Catalini, Nina K Iversen, Morten S Jensen, Sebastian Frische, Leif Østergaard
Vascular changes are thought to contribute to the development of Alzheimer's disease, and both cerebral blood flow and its responses during neural activation are reduced before Alzheimer's disease symptoms onset. One hypothetical explanation is that capillary dysfunction reduces oxygen extraction efficacy. This study compares the morphology and hemodynamics of the microvasculature in the somatosensory cortex of 18-month-old APP(SWE)/PS1ΔE9 (transgenic [Tg]) mice and wild-type (WT) littermates. In particular, the extent to which their capillary transit times homogenize during functional activation was measured and compared...
October 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29122668/estimation-of-physiological-sources-of-nonlinearity-in-blood-oxygenation-level-dependent-contrast-signals
#15
Daehun Kang, Yul-Wan Sung, Satoshi Shioiri
Blood oxygenation level-dependent (BOLD) contrast appears through a variation in the transverse relaxation rate of magnetic resonance signals induced by neurovascular coupling and is known to have nonlinear characteristics along echo time (TE) due to the intra-vasculature. However, the physiological causes of this nonlinearity are unclear. We attempted to estimate the physiological information related to the nonlinearity of BOLD signals by using a two-compartment model. For this purpose, we used a multi-echo gradient-echo echo-planar imaging sequence and developed a computational method to estimate the physiological information from the TE-dependent BOLD signals...
November 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29119370/vasoconstriction-and-impairment-of-neurovascular-coupling-after-subarachnoid-hemorrhage-a-descriptive-analysis-of-retinal-changes
#16
Catharina Conzen, Walid Albanna, Miriam Weiss, David Kürten, Walthard Vilser, Konstantin Kotliar, Charlotte Zäske, Hans Clusmann, Gerrit Alexander Schubert
Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C)...
November 8, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29070789/the-electrophysiological-connectome-is-maintained-in-healthy-elders-a-power-envelope-correlation-meg-study
#17
N Coquelet, A Mary, P Peigneux, S Goldman, V Wens, X De Tiège
Functional magnetic resonance imaging (fMRI) studies report age-related changes in resting-state functional connectivity (rsFC), suggesting altered or reorganized connectivity patterns with age. However, age-related changes in neurovascular coupling might also partially account for altered connectivity patterns. Here, we used resting-state magnetoencephalography (MEG) and a connectome approach in carefully selected healthy young adults and elders. The MEG connectome was estimated as rsFC matrices involving forty nodes from six major  resting-state networks...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29060865/simultaneous-estimation-of-the-in-mean-and-in-variance-causal-connectomes-of-the-human-brain
#18
A Duggento, L Passamonti, M Guerrisi, N Toschi
In recent years, the study of the human connectome (i.e. of statistical relationships between non spatially contiguous neurophysiological events in the human brain) has been enormously fuelled by technological advances in high-field functional magnetic resonance imaging (fMRI) as well as by coordinated world wide data-collection efforts like the Human Connectome Project (HCP). In this context, Granger Causality (GC) approaches have recently been employed to incorporate information about the directionality of the influence exerted by a brain region on another...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060779/hemodynamic-response-to-optogenetic-stimulation-varied-under-different-stimulus-parameters
#19
B Bo, W Li, Y Wang, Y Li, S Tong
The coupling between neuronal activity and cerebral blood flow(CBF), known as neurovascular coupling, serves as the basis of functional brain imaging. Optogenetics provides a precise and selective approach to manipulate the activity in cell-specific neurons. It has been used in neuroscience research for comprehensive understanding about the light-evoked neurovascular coupling in rodent neuronal circuits. However, the spatiotemporal CBF response characteristics under different stimulus parameters such as pulse width and frequency remains unclear due to the lack of efficient CBF imaging technology...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058353/fast-ca-2-responses-in-astrocyte-end-feet-and-neurovascular-coupling-in-mice
#20
Barbara Lykke Lind, Sanne Barsballe Jessen, Micael Lønstrup, Charlène Joséphine, Gilles Bonvento, Martin Lauritzen
Cerebral blood flow (CBF) is regulated by the activity of neurons and astrocytes. Understanding how these cells control activity-dependent increases in CBF is crucial to interpreting functional neuroimaging signals. The relative importance of neurons and astrocytes is debated, as are the functional implications of fast Ca(2+) changes in astrocytes versus neurons. Here, we used two-photon microscopy to assess Ca(2+) changes in neuropil, astrocyte processes, and astrocyte end-feet in response to whisker pad stimulation in mice...
October 23, 2017: Glia
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