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Neurovascular coupling

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https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#1
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27903813/abnormal-neurovascular-coupling-during-status-epilepticus-migrainosus-in-sturge-weber-syndrome
#2
Moksh Sethi, Magdalena A Kowalczyk, Linda J Dalic, John S Archer, Graeme D Jackson
No abstract text is available yet for this article.
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27900344/neurovascular-coupling-develops-alongside-neural-circuits-in-the-postnatal-brain
#3
COMMENT
Mariel G Kozberg, Elizabeth M C Hillman
In the adult brain, increases in local neural activity are accompanied by increases in regional blood flow. This relationship between neural activity and hemodynamics is termed neurovascular coupling and provides the blood flow-dependent contrast detected in functional magnetic resonance imaging (fMRI). Neurovascular coupling is commonly assumed to be consistent and reliable from birth; however, numerous studies have demonstrated markedly different hemodynamics in the early postnatal brain. Our recent study in J...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27891612/neurovascular-mechanisms-underlying-augmented-cold-induced-reflex-cutaneous-vasoconstriction-in-human-hypertension
#4
Jody L Greaney, W Larry Kenney, Lacy M Alexander
Despite ample evidence of dysregulated sympathetic control of the peripheral vasculature in hypertension, no studies have examined integrated neurovascular function during cold stress in hypertensive adults (HTN). We hypothesized that (1) whole-body cooling would elicit greater cutaneous vasoconstriction and greater increases in skin sympathetic nervous system activity (SSNA) in HTN (n = 14; 56 ± 2 yrs) compared to age-matched normotensive adults (NTN; n = 14; 55 ± 2 yrs) and (2) augmented reflex vasoconstriction in HTN would be mediated by an increase in cutaneous vascular adrenergic sensitivity and a greater contribution of non-adrenergic sympathetic co-transmitters...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27879386/mitochondrial-calcium-homeostasis-implications-for-neurovascular-and-neurometabolic-coupling
#5
REVIEW
Sridhar S Kannurpatti
Mitochondrial function is critical to maintain high rates of oxidative metabolism supporting energy demands of both spontaneous and evoked neuronal activity in the brain. Mitochondria not only regulate energy metabolism, but also influence neuronal signaling. Regulation of "energy metabolism" and "neuronal signaling" (i.e. neurometabolic coupling), which are coupled rather than independent can be understood through mitochondria's integrative functions of calcium ion (Ca(2+)) uptake and cycling. While mitochondrial Ca(2+) do not affect hemodynamics directly, neuronal activity changes are mechanistically linked to functional hyperemic responses (i...
November 22, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27865779/impairment-of-neurovascular-coupling-in-type-1-diabetes-mellitus-in-rats-is-prevented-by-pancreatic-islet-transplantation-and-reversed-by-a-semi-selective-pkc-inhibitor
#6
Francesco Vetri, Meirigeng Qi, Haoliang Xu, Jose Oberholzer, Chanannait Paisansathan
Streptozotocin (STZ)-induced chronic hyperglycemia has a detrimental effect on neurovascular coupling, linked to increased PKC-mediated phosphorylation and PKC isoform expression changes. Here, we sought to determine whether: 1) selective PKC-α/β/γ inhibitor, GF109203X, could reverse the effects of chronic hyperglycemia on cerebrovascular reactivity; 2) pancreatic islet transplantation could prevent the development of cerebrovascular impairment seen in a rat model of Type 1 Diabetes. We studied the effect of GF109203X in diabetic (DM), non-diabetic (ND), and transplanted (TR) Lewis rats during either sciatic nerve stimulation (SNS) or the topical applications of the large-conductance Ca(2+)-operated K(+) (BKCa) channel opener, NS1619, or the K(+) inward rectifier (Kir) channel agonist, KCl...
November 16, 2016: Brain Research
https://www.readbyqxmd.com/read/27845201/impaired-neurovascular-coupling-in-aging-and-alzheimer-s-disease-contribution-of-astrocyte-dysfunction-and-endothelial-impairment-to-cognitive-decline
#7
REVIEW
Stefano Tarantini, Cam Ha T Tran, Grant R Gordon, Zoltan Ungvari, Anna Csiszar
The importance of (micro)vascular contributions to cognitive impairment and dementia (VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age-related cerebromicrovascular pathologies are a subject of intensive research. In particular, aging impairs the increase in cerebral blood flow triggered by neural activation (termed neurovascular coupling or functional hyperemia), a critical mechanism that matches oxygen and nutrient delivery with the increased demands in active brain regions...
November 12, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27832709/a-model-of-neurovascular-coupling-and-the-bold-response-part-i
#8
E J Mathias, M J Plank, T David
The mechanisms with which neurons communicate with the vasculature to increase blood flow, termed neurovascular coupling is still unclear primarily due to the complex interactions between many parameters and the difficulty in accessing, monitoring and measuring them in the highly heterogeneous brain. Hence a solid theoretical framework based on existing experimental knowledge is necessary to study the relation between neural activity, the associated vasoactive factors released and their effects on the vasculature...
November 11, 2016: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/27832702/a-model-of-neurovascular-coupling-and-the-bold-response-part-ii
#9
E J Mathias, M J Plank, T David
A mathematical model is developed which describes a signalling mechanism of neurovascular coupling with a model of a pyramidal neuron and its corresponding fMRI BOLD response. In the first part of two papers (Part I) we described the integration of the neurovascular coupling unit extended to include a complex neuron model, which includes the important Na/K ATPase pump, with a model that provides a BOLD signal taking its input from the cerebral blood flow and the metabolic rate of oxygen consumption. We showed that this produced a viable signal in terms of initial dip, positive and negative BOLD signals...
November 11, 2016: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/27832340/the-neurovascular-unit-and-the-pathophysiologic-basis-of-diabetic-retinopathy
#10
REVIEW
Thomas W Gardner, Jose R Davila
PURPOSE: To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy. METHODS: Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive "dis-integration" of the retinal neurovascular unit with the progression of diabetes. RESULTS: Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice...
November 10, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27821575/vasculo-neuronal-coupling-retrograde-vascular-communication-to-brain-neurons
#11
Ki Jung Kim, Juan Ramiro Diaz, Jennifer A Iddings, Jessica A Filosa
: Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone influences resting neuronal function is not known. Using a multidisciplinary approach in both rat and mice brain slices, we determined if flow/pressure-evoked increases or decreases in parenchymal arteriole vascular tone which result in arteriole constriction and dilation, respectively altered resting cortical pyramidal neuron activity. We present evidence for intercellular communication in the brain involving a flow of information from vessel-to-astrocyte-to neuron, a direction opposite to that of classic neurovascular coupling and referred here as vasculo-neuronal coupling (VNC)...
November 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27793855/functional-vascular-contributions-to-cognitive-impairment-and-dementia-vcid-mechanisms-and-consequences-of-cerebral-microvascular-dysfunction-in-aging
#12
Peter Toth, Stefano Tarantini, Anna Csiszar, Zoltan I Ungvari
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) is expected to have a major role in preserving brain health in older individuals...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27789262/reward-magnitude-tracking-by-neural-populations-in-ventral-striatum
#13
Ana M Fiallos, Sarah J Bricault, Lili X Cai, Hermoon A Worku, Matthew T Colonnese, Gil Westmeyer, Alan Jasanoff
Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad network of structures activated by behaviorally characterized levels of rewarding stimulation. Correlation of psychometric behavioral measurements with fMRI response magnitudes revealed regions whose activity corresponded closely to the subjective magnitude of rewards...
October 24, 2016: NeuroImage
https://www.readbyqxmd.com/read/27785828/rapid-sodium-signaling-couples-glutamate-uptake-to-breakdown-of-atp-in-perivascular-astrocyte-endfeet
#14
Julia Langer, Niklas J Gerkau, Amin Derouiche, Christian Kleinhans, Behrouz Moshrefi-Ravasdjani, Michaela Fredrich, Karl W Kafitz, Gerald Seifert, Christian Steinhäuser, Christine R Rose
Perivascular endfeet of astrocytes are highly polarized compartments that ensheath blood vessels and contribute to the blood-brain barrier. They experience calcium transients with neuronal activity, a phenomenon involved in neurovascular coupling. Endfeet also mediate the uptake of glucose from the blood, a process stimulated in active brain regions. Here, we demonstrate in mouse hippocampal tissue slices that endfeet undergo sodium signaling upon stimulation of glutamatergic synaptic activity. Glutamate-induced endfeet sodium transients were diminished by TFB-TBOA, suggesting that they were generated by sodium-dependent glutamate uptake...
October 27, 2016: Glia
https://www.readbyqxmd.com/read/27775719/astrocytes-mediate-neurovascular-signaling-to-capillary-pericytes-but-not-to-arterioles
#15
Anusha Mishra, James P Reynolds, Yang Chen, Alexander V Gourine, Dmitri A Rusakov, David Attwell
Active neurons increase their energy supply by dilating nearby arterioles and capillaries. This neurovascular coupling underlies blood oxygen level-dependent functional imaging signals, but its mechanism is controversial. Canonically, neurons release glutamate to activate metabotropic glutamate receptor 5 (mGluR5) on astrocytes, evoking Ca(2+) release from internal stores, activating phospholipase A2 and generating vasodilatory arachidonic acid derivatives. However, adult astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2+) from stores does not affect neurovascular coupling...
December 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27752519/intraoperative-video-rate-hemodynamic-response-assessment-in-human-cortex-using-snapshot-hyperspectral-optical-imaging
#16
Julien Pichette, Audrey Laurence, Leticia Angulo, Frederic Lesage, Alain Bouthillier, Dang Khoa Nguyen, Frederic Leblond
Using light, we are able to visualize the hemodynamic behavior of the brain to better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of tissue using endogenous chromophores necessitates spectroscopic detection to ensure molecular specificity as well as sufficiently high imaging speed and signal-to-noise ratio, to allow dynamic physiological changes to be captured, isolated, and used as surrogate of pathophysiological processes. An optical imaging system is introduced using a 16-bands on-chip hyperspectral camera...
October 2016: Neurophotonics
https://www.readbyqxmd.com/read/27699123/imaging-brain-activity-during-seizures-in-freely-behaving-rats-using-a-miniature-multi-modal-imaging-system
#17
Iliya Sigal, Margaret M Koletar, Dene Ringuette, Raanan Gad, Melanie Jeffrey, Peter L Carlen, Bojana Stefanovic, Ofer Levi
We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 μm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27629101/multi-modal-assessment-of-neurovascular-coupling-during-cerebral-ischaemia-and-reperfusion-using-remote-middle-cerebral-artery-occlusion
#18
Brad A Sutherland, Jonas C Fordsmann, Chris Martin, Ain A Neuhaus, Brent M Witgen, Henning Piilgaard, Micael Lønstrup, Yvonne Couch, Nicola R Sibson, Martin Lauritzen, Alastair M Buchan
Hyperacute changes in cerebral blood flow during cerebral ischaemia and reperfusion are important determinants of injury. Cerebral blood flow is regulated by neurovascular coupling, and disruption of neurovascular coupling contributes to brain plasticity and repair problems. However, it is unknown how neurovascular coupling is affected hyperacutely during cerebral ischaemia and reperfusion. We have developed a remote middle cerebral artery occlusion model in the rat, which enables multi-modal assessment of neurovascular coupling immediately prior to, during and immediately following reperfusion...
September 14, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27627747/dynamic-and-static-vessel-analysis-in-patients-with-retinitis-pigmentosa-a-pilot-study-of-vascular-diameters-and-functionality
#19
Pierluigi Iacono, Maurizio Battaglia Parodi, Carlo La Spina, Giampaolo Zerbini, Francesco Bandello
PURPOSE: To evaluate in vivo the vascular anatomy and functionality of early manifestation retinitis pigmentosa (RP) by means of a dynamic and static vessel analyzer. METHODS: Fourteen patients with early RP and 14 normal subjects were consecutively enrolled in this observational, prospective study. Each patient underwent a complete ophthalmologic examination, including dynamic and static retinal vessel analysis using the Dynamic Vessel Analyzer. RESULTS: The patients with RP and the control group were well matched in age and sex...
September 13, 2016: Retina
https://www.readbyqxmd.com/read/27619153/binaural-blood-flow-control-by-astrocytes-listening-to-synapses-and-the-vasculature
#20
Anusha Mishra
Astrocytes are the most common glial cells in the brain with fine processes and endfeet that intimately contact both neuronal synapses and the cerebral vasculature. They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca(2+) -dependent signalling pathways such as K(+) release through BK channels, and the production and release of arachidonic acid metabolites. They are also involved in maintaining the resting tone of the cerebral vessels by releasing ATP and COX-1 derivatives...
September 13, 2016: Journal of Physiology
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