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https://www.readbyqxmd.com/read/29337197/brain-perfusion-alterations-in-tick-borne-encephalitis-preliminary-report
#1
Zuzanna Tyrakowska-Dadełło, Eugeniusz Tarasów, Dariusz Janusek, Anna Moniuszko-Malinowska, Joanna Zajkowska, Sławomir Pancewicz
BACKGROUND: Magnetic resonance imaging (MRI) changes in Tick-borne encephalitis (TBE) are nonspecific and pathophysiologic mechanisms leading to their formation remain unclear. This study aimed to investigate brain perfusion in TBE patients using dynamic susceptibility contrast (DSC) MR perfusion imaging. METHODS: MRI scans were performed in 12 patients in the acute phase, 3-5days after TBE diagnosis, with conventional MR images and DSC-MRI perfusion studies. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) parametric maps were created...
January 11, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29330390/freezing-the-graft-is-not-necessary-for-autotransplants-for-plasma-cell-myeloma-and-lymphomas
#2
Amado Kardduss-Urueta, Robert Peter Gale, César H Gutierrez-Aguirre, Miguel Angel Herrera-Rojas, Iván Murrieta-Álvarez, Rosendo Perez-Fontalvo, Guillermo J Ruiz-Delgado, Giovanni Ruiz-Rojas, Gregorio Jaimovich, Leonardo Feldman, Nancy Labastida-Mercado, Alicia Endara, Martín Castro, Samantha Galindo-Becerra, María Angélica Cardona-Molina, David Gomez-Almaguer, Guillermo J Ruiz-Argüelles
We studied rates of granulocyte and platelets recovery in 359 consecutive subjects receiving blood cell infusions in the context of autotransplants for plasma cell myeloma (N = 216) and lymphomas (N = 143). Blood cells were mobilised with filgrastim given for 4-5 days and collected after a median of 2 (range, 1-2) apheresis. Apheresis products were stored at 4° C for a median of 3 days (range, 2-6 days). Most subjects received carmustine, etoposide, cytarabine and melphalan (BEAM), cyclophosphamide, carmustine and etoposide (CBV) or high-dose melphalan...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29323247/leakage-correction-improves-prognosis-prediction-of-dynamic-susceptibility-contrast-perfusion-mri-in-primary-central-nervous-system-lymphoma
#3
Yeon Soo Kim, Seung Hong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn, Sung-Hye Park, Jae-Kyung Won, Tae Min Kim, Chul-Kee Park, Il Han Kim
To evaluate whether the cerebral blood volume (CBV) measurement with leakage correction from dynamic susceptibility contrast perfusion weighted imaging can be useful in predicting prognosis for primary central nervous system lymphoma (PCNSL). 46 PCNSL patients were included and classified by radiation therapy (RT) stratification into RT (n = 30) and non-RT (n = 16) groups. The corresponding histogram parameters of normalized CBV (nCBV) maps with or without leakage correction were calculated on contrast-enhanced T1 weighted image (CE T1WI) or on fluid attenuated inversion recovery image...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314418/cerebral-blood-volume-mapping-with-ferumoxytol-in-dynamic-susceptibility-contrast-perfusion-mri-comparison-to-standard-of-care
#4
Csanad G Varallyay, Eric Nesbit, Andrea Horvath, Peter Varallyay, Rongwei Fu, Seymur Gahramanov, Leslie L Muldoon, Xin Li, William D Rooney, Edward A Neuwelt
BACKGROUND: Cerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow-up of brain tumors. Ferumoxytol, a long-circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established. PURPOSE: To compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time-intensity curves and CBV maps in normal-appearing brain regions...
January 4, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29285809/investigation-of-the-bold-and-cbv-fmri-responses-to-somatosensory-stimulation-in-awake-marmosets-callithrix-jacchus
#5
Yoshiyuki Hirano, Cecil C Yen, Junjie V Liu, Julie B Mackel, Hellmut Merkle, George C Nascimento, Bojana Stefanovic, Afonso C Silva
Understanding the spatiotemporal features of the hemodynamic response function (HRF) to brain stimulation is essential for the correct application of neuroimaging methods to study brain function. Here, we investigated the spatiotemporal evolution of the blood oxygen level-dependent (BOLD) and cerebral blood volume (CBV) HRF in conscious, awake marmosets (Callithrix jacchus), a New World non-human primate with a lissencephalic brain and with growing use in biomedical research. The marmosets were acclimatized to head fixation and placed in a 7-T magnetic resonance imaging (MRI) scanner...
December 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29249925/determining-excitatory-and-inhibitory-neuronal-activity-from-multimodal-fmri-data-using-a-generative-hemodynamic-model
#6
Martin Havlicek, Dimo Ivanov, Alard Roebroeck, Kamil Uludağ
Hemodynamic responses, in general, and the blood oxygenation level-dependent (BOLD) fMRI signal, in particular, provide an indirect measure of neuronal activity. There is strong evidence that the BOLD response correlates well with post-synaptic changes, induced by changes in the excitatory and inhibitory (E-I) balance between active neuronal populations. Typical BOLD responses exhibit transients, such as the early-overshoot and post-stimulus undershoot, that can be linked to transients in neuronal activity, but they can also result from vascular uncoupling between cerebral blood flow (CBF) and venous cerebral blood volume (venous CBV)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29240420/iodine-promoted-aromatization-of-p-menthane-type-phytocannabinoids
#7
Federica Pollastro, Diego Caprioglio, Patrizia Marotta, Aniello Schiano Moriello, Luciano De Petrocellis, Orazio Taglialatela-Scafati, Giovanni Appendino
Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in terms of simplicity and substrate range, which includes not only tricyclic tetrahydrocannabinols such as Δ9-THC (2a) but also bicyclic phytocannabinoids such as cannabidiol (CBD, 3a). Lower homologues from the viridin series (2c and 3c, respectively) afforded cannabivarin (CBV), a non-narcotic compound that, when investigated against a series of ionotropic (thermo-TRPs) biological end-points of phytocannabinoids, retained the submicromolar TRPA1-activating and TRPM8-inhibiting properties of CBN, while also potently activating TRPV2...
December 14, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29224727/high-resolution-cbv-fmri-allows-mapping-of-laminar-activity-and-connectivity-of-cortical-input-and-output-in-human-m1
#8
Laurentius Huber, Daniel A Handwerker, David C Jangraw, Gang Chen, Andrew Hall, Carsten Stüber, Javier Gonzalez-Castillo, Dimo Ivanov, Sean Marrett, Maria Guidi, Jozien Goense, Benedikt A Poser, Peter A Bandettini
Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers. However, it is unknown to what level human fMRI is specific and sensitive enough to reveal directional functional activity across layers. To answer this question, we developed acquisition and analysis methods for blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-based laminar fMRI and used these to discriminate four different tasks in the human motor cortex (M1)...
December 20, 2017: Neuron
https://www.readbyqxmd.com/read/29217747/mr-perfusion-to-determine-the-status-of-collaterals-in-patients-with-acute-ischemic-stroke-a-look-beyond-time-maps
#9
K Nael, A Doshi, R De Leacy, J Puig, M Castellanos, J Bederson, T P Naidich, J Mocco, M Wintermark
BACKGROUND AND PURPOSE: Patients with acute stroke with robust collateral flow have better clinical outcomes and may benefit from endovascular treatment throughout an extended time window. Using a multiparametric approach, we aimed to identify MR perfusion parameters that can represent the extent of collaterals, approximating DSA. MATERIALS AND METHODS: Patients with anterior circulation proximal arterial occlusion who had baseline MR perfusion and DSA were evaluated...
December 7, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29197390/evaluation-of-b1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#10
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate the effect of B1inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29184763/usefulness-of-enhancement-perfusion-mismatch-in-differentiation-of-cns-lymphomas-from-other-enhancing-malignant-tumors-of-the-brain
#11
Pradeep Goyal, Yogesh Kumar, Nishant Gupta, Ajay Malhotra, Saurabh Gupta, Sonali Gupta, Manisha Mangla, Rajiv Mangla
Background: Surgical planning and treatment options for primary or secondary central nervous system lymphomas (PCNSL or SCNSL) are different from other enhancing malignant lesions such as glioblastoma multiforme (GBM), anaplastic gliomas and metastases; so, it is critical to distinguish them preoperatively. We hypothesized that enhancement-perfusion (E-P) mismatch on dynamic susceptibility weighted magnetic resonance (DSC-MR) perfusion imaging which corresponds to low mean relative cerebral blood volume (mean rCBV) in an enhancing portion of the tumor should allow differentiation of CNS lymphomas from other enhancing malignant lesions...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29184204/weak-correlations-between-hemodynamic-signals-and-ongoing-neural-activity-during-the-resting-state
#12
Aaron T Winder, Christina Echagarruga, Qingguang Zhang, Patrick J Drew
Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29163351/computed-tomography-perfusion-alberta-stroke-program-early-computed-tomography-score-is-associated-with-hemorrhagic-transformation-after-acute-cardioembolic-stroke
#13
Lan Liu, Bo Wu, Jinglong Zhao, Yanyan Cao, Nikita Dedhia, Louis R Caplan, Qiaoshu Wang
Alberta Stroke Program Early Computed Tomography (CT) score (ASPECTS) has been applied to CT perfusion (CTP) with good interrater agreement to predict early ischemic stroke, and it can be useful in decision making in acute ischemic stroke. The aim of the present study was to assess the predictive value of CTP ASPECTS of hemorrhagic transformation (HT) in acute cardioembolic stroke. This is a single-enter, retrospective study. All patients hospitalized with acute cardioembolic stroke from January 2008 to September 2013 were included...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29150710/computed-tomography-perfusion-is-a%C3%A2-useful-adjunct-to-computed-tomography-angiography-in-the-diagnosis-of-brain-death
#14
M Sawicki, J Sołek-Pastuszka, K Chamier-Ciemińska, A Walecka, J Walecki, R Bohatyrewicz
BACKGROUND: In the diagnosis of brain death (BD), computed tomography angiography (CTA) results in some cases show intracranial filling, leading to diagnostic confusion. Because cerebral circulatory arrest commences at the capillary level, we hypothesized that computed tomography perfusion (CTP) would be a more sensitive approach than CTA; therefore, the aim of the study was to compare the sensitivities of CTP and CTA in the diagnosis of BD. MATERIAL AND METHODS: Whole brain CTP was performed in patients in the intensive care unit diagnosed with BD and CTA was derived from CTP datasets...
November 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29097413/spatial-correlation-of-pathology-and-perfusion-changes-within-the-cortex-and-white-matter-in-multiple-sclerosis
#15
A D Mulholland, R Vitorino, S-P Hojjat, A Y Ma, L Zhang, L Lee, T J Carroll, C G Cantrell, C R Figley, R I Aviv
BACKGROUND AND PURPOSE: The spatial correlation between WM and cortical GM disease in multiple sclerosis is controversial and has not been previously assessed with perfusion MR imaging. We sought to determine the nature of association between lobar WM, cortical GM, volume and perfusion. MATERIALS AND METHODS: Nineteen individuals with secondary-progressive multiple sclerosis, 19 with relapsing-remitting multiple sclerosis, and 19 age-matched healthy controls were recruited...
November 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29096054/comparison-of-ferumoxytol-based-cerebral-blood-volume-estimates-using-quantitative-r1-and-r2-relaxometry
#16
Leonardo A Rivera-Rivera, Tilman Schubert, Gesine Knobloch, Patrick A Turski, Oliver Wieben, Scott B Reeder, Kevin M Johnson
PURPOSE: Cerebral perfusion is commonly assessed clinically with dynamic susceptibility contrast MRI using a bolus injection of gadolinium-based contrast agents, resulting in semi-quantitative values of cerebral blood volume (CBV). Steady-state imaging with ferumoxytol allows estimation of CBV with the potential for higher precision and accuracy. Prior CBV studies have focused on the signal disrupting T2* effects, but ferumoxytol also has high signal-enhancing T1 relaxivity. The purpose of this study was to investigate and compare CBV estimation using T1 and T2*, with the goal of understanding the contrast mechanisms and quantitative differences...
November 2, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29089671/role-of-whole-brain-computed-tomography-perfusion-in-head-injury-patients-to-predict-outcome
#17
T S Bindu, Sameer Vyas, Niranjan Khandelwal, Vikas Bhatia, Sivashanmugam Dhandapani, Ajay Kumar, Chirag K Ahuja
PURPOSE: To evaluate utility, pattern, and extent of perfusion abnormalities in traumatic brain injury by using whole-brain computed tomography perfusion (CTP) and to assess co-relation of CTP data clinically with Glasgow outcome score (GOS). MATERIALS AND METHODS: Prospective analytic evaluation of the traumatic head injury patients who were immediately taken up for CTP was done. Patient's demographic, clinical, and radiological findings were tabulated and analyzed...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29080056/oxygen-15-labeled-co2-o2-and-co-pet-in-small-animals-evaluation-using-a-3d-mode-micropet-scanner-and-impact-of-reconstruction-algorithms
#18
Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa, Jun Hatazawa
BACKGROUND: Positron emission tomography (PET) studies using (15)O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabolic rate of oxygen (CMRO2) and cerebral blood volume (CBV), respectively. In preclinical studies, however, PET studies using (15)O-labeled gases are not widely performed because of the technical difficulties associated with handling labeled gases with a short half-life...
October 27, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29074632/improved-spatiotemporal-resolution-of-dynamic-susceptibility-contrast-perfusion-mri-in-brain-tumors-using-simultaneous-multi-slice-echo-planar-imaging
#19
A Chakhoyan, K Leu, W B Pope, T F Cloughesy, B M Ellingson
DSC perfusion MR imaging in brain tumors requires a trade-off between spatial and temporal resolution, resulting in less spatial coverage to meet the temporal resolution requirements for accurate relative CBV estimation. DSC-MR imaging could potentially benefit from the advantages associated with simultaneous multi-slice imaging, including increased spatiotemporal resolution. In the current article, we demonstrate how simultaneous multi-slice EPI can be used to improve DSC-MR imaging spatiotemporal resolution in patients with glioblastoma...
January 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29074483/transjugular-intrahepatic-portosystemic-shunt-impact-on-systemic-haemodynamics-and-renal-and-cardiac-function-in-patients-with-cirrhosis
#20
Troels Malte Busk, Flemming Bendtsen, Jørgen Hjelm Poulsen, Jens Otto Clemmesen, Fin Stolze Larsen, Jens Peter Goetze, Jens Schmidt Iversen, Magnus Thorsten Jensen, Rasmus Møgelvang, Erling Bjerregaard Pedersen, Jesper Noergaard Bech, Søren Møller
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension and possibly increases central blood volume (CBV). Moreover, renal function often improves; however, its effects on cardiac function are unclear. The aims of our study were to examine the effects of TIPS on hemodynamics and renal and cardiac function in patients with cirrhosis. METHODS: In 25 cirrhotic patients, we analyzed systemic, cardiac, and splanchnic hemodynamics by catheterization of the liver veins and right heart chambers before and 1 week after TIPS...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
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