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https://www.readbyqxmd.com/read/29767308/differentiating-pseudoprogression-from-true-progression-analysis-of-radiographic-biologic-and-clinical-clues-in-gbm
#1
Lindsay S Rowe, John A Butman, Megan Mackey, Joanna H Shih, Theresa Cooley-Zgela, Holly Ning, Mark R Gilbert, DeeDee K Smart, Kevin Camphausen, Andra V Krauze
INTRODUCTION: Pseudoprogression (PsP) is a diagnostic dilemma in glioblastoma (GBM) after chemoradiotherapy (CRT). Magnetic resonance imaging (MRI) features may fail to distinguish PsP from early true progression (eTP), however clinical findings may aid in their distinction. METHODS: Sixty-seven patients received CRT for GBM between 2003 and 2016, and had pre- and post-treatment imaging suitable for retrospective evaluation using RANO criteria. Patients with signs of progression within the first 12-weeks post-radiation (P-12) were selected...
May 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29766930/measurement-of-the-permeability-perfusion-and-histogram-characteristics-in-relapsing-remitting-multiple-sclerosis-using-dynamic-contrast-enhanced-mri-with-extended-tofts-linear-model
#2
Ping Yin, Hua Xiong, Yi Liu, Shambhu K Sah, Chun Zeng, Jingjie Wang, Yongmei Li, Nan Hong
Objective: To investigate the application value of using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with extended Tofts linear model for relapsing-remitting multiple sclerosis (RRMS) and its correlation with expanded disability status scale (EDSS) scores and disease duration. Materials and Methods: Thirty patients with multiple sclerosis (MS) underwent conventional magnetic resonance imaging (MRI) and DCE-MRI with a 3.0 Tesla MR scanner. An extended Tofts linear model was used to quantitatively measure MR imaging biomarkers...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764622/absolute-cbv-for-the-differentiation-of-recurrence-and-radionecrosis-of-brain-metastases-after-gamma-knife-radiotherapy-a-comparison-with-relative-cbv
#3
B Wang, B Zhao, Y Zhang, M Ge, P Zhao, Na Sun, C Li, Q Pang, S Xu, Y Liu
AIM: To investigate the efficiency of absolute cerebral blood volume (CBV) in the differentiation of tumour recurrence (TR) and radionecrosis (RN) in brain metastases (BM) and to evaluate the performance of absolute CBV compared to relative CBV (rCBV). MATERIALS AND METHODS: Between March 2015 and June 2017, 46 patients with BM underwent quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) because new enhancement had been demonstrated in irradiated lesions after gamma knife radiotherapy...
May 12, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29753641/consistency-of-normalized-cerebral-blood-volume-values-in-glioblastoma-using-different-leakage-correction-algorithms-on-dynamic-susceptibility-contrast-magnetic-resonance-imaging-data-without-and-with-prebolus
#4
Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S Kirschke, Benedikt Wiestler, Christine Preibisch
BACKGROUND AND PURPOSE: Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli...
May 10, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29748200/extent-of-microstructural-tissue-damage-correlates-with-hemodynamic-failure-in-high-grade-carotid-occlusive-disease-an-mri-study-using-quantitative-t2-and-dsc-perfusion
#5
A Seiler, R Deichmann, U Nöth, A Lauer, W Pfeilschifter, O C Singer, M Wagner
BACKGROUND AND PURPOSE: Chronic hemodynamic impairment in high-grade carotid occlusive disease is thought to cause microstructural abnormalities that might be subclinical or lead to subtle symptoms including cognitive impairment. Quantitative MR imaging allows assessing pathologic structural changes beyond macroscopically visible tissue damage. In this study, high-resolution quantitative T2 mapping combined with DSC-based PWI was used to investigate quantitative T2 changes as a potential marker of microstructural damage in relation to hemodynamic impairment in patients with unilateral high-grade carotid occlusive disease...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29738908/rodent-cerebral-blood-volume-cbv-changes-during-hypercapnia-observed-using-magnetic-particle-imaging-mpi-detection
#6
Clarissa Zimmerman Cooley, Joseph B Mandeville, Erica E Mason, Emiri T Mandeville, Lawrence L Wald
Magnetic Particle Imaging (MPI) is a rapidly developing imaging modality that directly measures and maps the concentration of injected superparamagnetic iron oxide nanoparticles (SPIOs). Since the agent does not cross the blood-brain barrier, cerebral SPIO concentration provides a direct probe of Cerebral Blood Volume (CBV). Here we provide an initial demonstration of the ability of MPI to detect functional CBV changes (fCBV) by monitoring SPIO concentration during hypercapnic manipulation in a rat model. As a tracer detection method, MPI offers a more direct probe of agent concentration and therefore fCBV than MRI measurements in which the agent is indirectly detected through perturbation of water relaxation time constants such as T2 ∗ ...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29730495/mouse-fmri-under-ketamine-and-xylazine-anesthesia-robust-contralateral-somatosensory-cortex-activation-in-response-to-forepaw-stimulation
#7
Hyun-Ji Shim, Won Beom Jung, Felix Schlegel, Joonsung Lee, Sangwoo Kim, Jungryun Lee, Seong-Gi Kim
Mouse fMRI is critically useful to investigate functions of transgenic mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9...
May 3, 2018: NeuroImage
https://www.readbyqxmd.com/read/29727439/accuracy-of-computed-tomographic-perfusion-in-diagnosis-of-brain-death-a-prospective-cohort-study
#8
Marcin Sawicki, Joanna Sołek-Pastuszka, Katarzyna Chamier-Ciemińska, Anna Walecka, Romuald Bohatyrewicz
BACKGROUND This study was designed to determine diagnostic accuracy of computed tomographic perfusion (CTP) compared to computed tomographic angiography (CTA) for the diagnosis of brain death (BD). MATERIAL AND METHODS Whole-brain CTP was performed in patients diagnosed with BD and in patients with devastating brain injury with preserved brainstem reflexes. CTA was derived from CTP datasets. Cerebral blood flow (CBF) and volume (CBV) were calculated in all brain regions. CTP findings were interpreted as confirming diagnosis of BD (positive) when CBF and CBV in all ROIs were below 10 mL/100 g/min and 1...
May 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29721688/radiogenomics-correlation-between-mr-imaging-features-and-major-genetic-profiles-in-glioblastoma
#9
Eun Kyoung Hong, Seung Hong Choi, Dong Jae Shin, Sang Won Jo, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn, Sung-Hye Park, Jae-Kyung Won, Tae Min Kim, Chul-Kee Park, Il Han Kim, Soon Tae Lee
OBJECTIVES: To assess the association between MR imaging features and major genomic profiles in glioblastoma. METHODS: Qualitative and quantitative imaging features such as volumetrics and histogram analysis from normalised CBV (nCBV) and ADC (nADC) were evaluated based on both T2WI and CET1WI. The imaging parameters of different genetic profile groups were compared and regression analyses were used for identifying imaging-molecular associations. Progression-free survival (PFS) was analysed by a Kaplan-Meier test and Cox proportional hazards model...
May 2, 2018: European Radiology
https://www.readbyqxmd.com/read/29708785/interval-change-in-diffusion-and-perfusion-mri-parameters-for-the-assessment-of-pseudoprogression-in-cerebral-metastases-treated-with-stereotactic-radiation
#10
James R Knitter, William K Erly, Baldassarre D Stea, Gerald M Lemole, Isabelle M Germano, Amish H Doshi, Kambiz Nael
OBJECTIVE: Apparent increases in the size of cerebral metastases after stereotactic radiosurgery (SRS) can be caused by pseudoprogression or true disease progression, which poses a diagnostic challenge at conventional MRI. The purpose of this study was to assess whether interval change in DWI and perfusion MRI parameters can differentiate pseudoprogression from progressive disease after treatment with SRS. MATERIALS AND METHODS: Patients with apparent growth of cerebral metastases after SRS treatment who underwent pre- and post-SRS DWI, dynamic susceptibility contrast (DSC)-MRI, and perfusion dynamic contrast-enhanced (DCE)-MRI were retrospectively evaluated...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29697052/resting-state-functional-connectivity-analysis-of-the-mouse-brain-using-intrinsic-optical-signal-imaging-of-cerebral-blood-volume-dynamics
#11
Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity (rsFC) of the human brain is closely related with neurological and psychiatric disorders. Mice are widely used to investigate the physiological mechanisms of such disorders, because of the applicability of invasive experimental techniques. Thus, studies on rsFC of the mouse brain are essential to link physiological mechanisms with these disorders in humans. In this study, we investigated the applicability of intrinsic optical signal imaging of cerebral blood volume (IOSI-CBV) for rsFC analysis of the mouse brain...
April 26, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29676844/differentiation-of-brain-infection-from-necrotic-glioblastoma-using-combined-analysis-of-diffusion-and-perfusion-mri
#12
Sanjeev Chawla, Sumei Wang, Suyash Mohan, MacLean Nasrallah, Gaurav Verma, Steven Brem, Donald M O'Rourke, Ronald L Wolf, Harish Poptani, S Ali Nabavizadeh
BACKGROUND: Accurate differentiation of brain infections from necrotic glioblastomas (GBMs) may not always be possible on morphologic MRI or on diffusion tensor imaging (DTI) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) if these techniques are used independently. PURPOSE: To investigate the combined analysis of DTI and DSC-PWI in distinguishing brain injections from necrotic GBMs. STUDY TYPE: Retrospective. POPULATION: Fourteen patients with brain infections and 21 patients with necrotic GBMs...
April 20, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29675474/brain-tumor-characterization-using-multibiometric-evaluation-of-mri
#13
Faris Durmo, Jimmy Lätt, Anna Rydelius, Silke Engelholm, Sara Kinhult, Krister Askaner, Elisabet Englund, Johan Bengzon, Markus Nilsson, Isabella M Björkman-Burtscher, Thomas Chenevert, Linda Knutsson, Pia C Sundgren
The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest...
March 2018: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29663430/effectiveness-of-a-new-single-needle-single-pump-dialysis-system-with-simultaneous-monitoring-of-dialysis-dose
#14
Wolfgang Bieser, Markus Welsch, Marten Jakob, Jörn Meibaum, David A Rodriguez, Henrik Wolff, Daniele Marcelli, Claudia Barth
To date, single-needle (SN) hemodialysis (HD) requires a dialysis machine equipped with two blood pumps-one controlling arterial blood flow (Qb) and one controlling venous Qb. B. Braun has developed an innovative single-pump SN HD system. Therefore, usability is improved by reducing complexity. The aim of this study was to compare dialysis parameters of the new single-pump SN HD system with a double-pump SN HD system available on the market (Fresenius Medical Care [FMC] 5008). In this two-armed crossover study, patients were randomized into two groups (B...
April 16, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29652541/dynamic-cerebral-autoregulation-is-impaired-during-sub-maximal-isometric-handgrip-in-patients-with-heart-failure
#15
Juliana R Caldas, Ronney B Panerai, Angela S M Salinet, Edson Bor-Seng-Shu, Filomena R B G Galas, Graziela S R Ferreira, Ligia Camara, Rogerio Hora Passos, Juliano P Almeida, Ricardo C Nogueira, Marcelo de Lima Oliveira M, Thompson G Robinson, Ludhmila A Hajjar
BACKGROUND: The incidence of neurological complications, including stroke and cognitive dysfunction is elevated in heart failure (HF) patients with reduced ejection fraction. We hypothesized that the cerebrovascular response to isometric handgrip (iHG) is altered in HF patients. METHODS: Adults with HF and healthy volunteers were included. Cerebral blood velocity (CBV, transcranial Doppler, middle cerebral artery) and arterial blood pressure (BP, Finometer) were continuously recorded supine for 6 minutes, corresponding to one min baseline, three min of iHG exercise, at 30% maximum voluntary contraction, followed by two min of recovery...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29598861/rapid-deployment-versus-conventional-bioprosthetic-valve-replacement-for-aortic-stenosis
#16
Stephan Ensminger, Buntaro Fujita, Timm Bauer, Helge Möllmann, Andreas Beckmann, Raffi Bekeredjian, Sabine Bleiziffer, Sandra Landwehr, Christian W Hamm, Friedrich W Mohr, Hugo A Katus, Wolfgang Harringer, Thomas Walther, Christian Frerker
BACKGROUND: Surgical aortic valve replacement using conventional biological valves (CBVs) is the standard of care for treatment of old patients with aortic valve disease. Recently, rapid deployment valves (RDVs) have been introduced. OBJECTIVES: The purpose of this study was to report the nationwide German experience concerning RDVs for treatment of aortic valve stenosis and provide a head-to-head comparison with CBVs. METHODS: A total of 22,062 patients who underwent isolated surgical aortic valve replacement using CBV or RDV between 2011 and 2015 were enrolled into the German Aortic Valve Registry...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29575406/knee-high-compression-socks-minimize-head-up-tilt-induced-cerebral-and-cardiovascular-responses-following-dynamic-exercise
#17
Tristan W Dorey, Myles W O'Brien, Susan A Robinson, Derek S Kimmerly
INTRODUCTION: In healthy individuals during a non-exercised state, knee-high compression socks (CS) may reduce the magnitude of lower limb venous pooling during orthostasis but are not effective at minimizing the incidence of presyncopal symptoms. However, exaggerated reductions in cerebral blood flow velocity (CBV), and cardiac stroke volume (SV) occur during passive head-up tilt (HUT) testing following dynamic exercise. It is unknown if CS can minimize post-exercise HUT-induced decrements in CBV and SV in this population...
March 25, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29574034/cerebrovascular-reactivity-cvr-mri-with-co2-challenge-a-technical-review
#18
Peiying Liu, Jill De Vis, Hanzhang Lu
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides important information about vascular health in a range of brain conditions and diseases. Unlike steady-state vascular parameters, such as cerebral blood flow (CBF) and cerebral blood volume (CBV), CVR measures the ability of cerebral vessels to dilate or constrict in response to challenges or maneuvers. Therefore, CVR mapping requires a physiological challenge while monitoring the corresponding hemodynamic changes in the brain...
March 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29572637/observer-variability-of-reference-tissue-selection-for-relativecerebral-blood-volume-measurements-in-glioma-patients
#19
Marcel T H Oei, Frederick J A Meijer, Jan-Jurre Mordang, Ewoud J Smit, Albert J S Idema, Bozena M Goraj, Hendrik O A Laue, Mathias Prokop, Rashindra Manniesing
OBJECTIVES: To assess observer variability of different reference tissues used for relative CBV (rCBV) measurements in DSC-MRI of glioma patients. METHODS: In this retrospective study, three observers measured rCBV in DSC-MR images of 44 glioma patients on two occasions. rCBV is calculated by the CBV in the tumour hotspot/the CBV of a reference tissue at the contralateral side for normalization. One observer annotated the tumour hotspot that was kept constant for all measurements...
March 23, 2018: European Radiology
https://www.readbyqxmd.com/read/29561941/analyzing-the-neuropsychological-characteristics-and-changes-in-serum-markers-of-patients-with-chronic-cerebral-circulation-insufficiency
#20
Jianhua Tang, Yuqing Zhen, Ling Yu, Cui Lv, Juan Zheng, Hui Liang
OBJECTIVE: To investigate the neuropsychological characteristics and changes in CRP, S100B, MBP, HSP-7, and NSE in serum. METHOD: Sixty-six (66) patients treated in our hospital as CCCI group were chosen for our study, and 90 patients with depression were selected as the depression group. The patients in both groups were examined with CT perfusion, depression, anxiety and cognition evaluation. Their serum CRP, S100B, MBP, HSP-70 and NSE levels were detected. Neuropsychological and serum markers characteristics were compared...
January 2018: Revista da Associação Médica Brasileira
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