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https://www.readbyqxmd.com/read/28631203/assessment-of-mri-contrast-agent-concentration-by-quantitative-susceptibility-mapping-qsm-application-to-estimation-of-cerebral-blood-volume-during-steady-state
#1
Emelie Lind, Linda Knutsson, Robin Kämpe, Freddy Ståhlberg, Ronnie Wirestam
OBJECTIVE: One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. MATERIALS AND METHODS: A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test-retest study...
June 19, 2017: Magma
https://www.readbyqxmd.com/read/28596159/in-vivo-relationship-between-hypoxia-and-angiogenesis-in-human-glioblastoma-a-multimodal-imaging-study
#2
Keven Ferreira da Ponte, David Hassanein Berro, Solène Collet, Jean-Marc Constans, Evelyne Emery, Samuel Valable, Jean-Sébastien Guillamo
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. This aggressiveness is in part attributed to the closely interrelated phenomena, tumor hypoxia and angiogenesis, although few in vivo data exist in human brain tumors. This work aims to study hypoxia and angiogenesis, in vivo and in situ, in patients admitted with GBM using multimodal imaging. Methods: 23 GBM patients were assessed by [(18)F]-FMISO PET and conventional and perfusion MRI prior to surgery. The level and location of hypoxia ([(18)F]-FMISO uptake, evaluated by tumor/blood ratio, T/B), vascularization (cerebral blood volume, CBV) and vascular permeability (contrast enhancement after gadolinium injection) were analyzed...
June 8, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28587332/three-dimensional-arterial-spin-labeling-imaging-and-dynamic-susceptibility-contrast-perfusion-weighted-imaging-value-in-diagnosing-glioma-grade-prior-to-surgery
#3
Hong Ma, Zizheng Wang, Kai Xu, Zefeng Shao, Chun Yang, Peng Xu, Xiaohua Liu, Chunfeng Hu, Xin Lu, Yutao Rong
The current study aimed to investigate whole-brain three-dimensional arterial spin labeling imaging (3D ASL) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI), in regards to their diagnostic value of preoperative glioma grade. The parameter values obtained after correction will be correlated with the diagnostic value of 3D ASL and DSC-PWI perfusion. In the current study, 50 patients with gliomas confirmed by pathology were used, including 27 low-grade gliomas (LGGs) and 23 high-grade gliomas (HGGs)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585082/magnetic-resonance-imaging-perfusion-is-associated-with-disease-severity-and-activity-in-multiple-sclerosis
#4
Piotr Sowa, Gro Owren Nygaard, Atle Bjørnerud, Elisabeth Gulowsen Celius, Hanne Flinstad Harbo, Mona Kristiansen Beyer
PURPOSE: The utility of perfusion-weighted imaging in multiple sclerosis (MS) is not well investigated. The purpose of this study was to compare baseline normalized perfusion measures in subgroups of newly diagnosed MS patients. We wanted to test the hypothesis that this method can differentiate between groups defined according to disease severity and disease activity at 1 year follow-up. METHODS: Baseline magnetic resonance imaging (MRI) including a dynamic susceptibility contrast perfusion sequence was performed on a 1...
June 5, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28584878/a-population-based-digital-reference-object-dro-for-optimizing-dynamic-susceptibility-contrast-dsc-mri-methods-for-clinical-trials
#5
Natenael B Semmineh, Ashley M Stokes, Laura C Bell, Jerrold L Boxerman, C Chad Quarles
The standardization and broad-scale integration of dynamic susceptibility contrast (DSC)-magnetic resonance imaging (MRI) have been confounded by a lack of consensus on DSC-MRI methodology for preventing potential relative cerebral blood volume inaccuracies, including the choice of acquisition protocols and postprocessing algorithms. Therefore, we developed a digital reference object (DRO), using physiological and kinetic parameters derived from in vivo data, unique voxel-wise 3-dimensional tissue structures, and a validated MRI signal computational approach, aimed at validating image acquisition and analysis methods for accurately measuring relative cerebral blood volume in glioblastomas...
March 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28577254/the-value-of-whole-brain-ct-perfusion-imaging-and-ct-angiography-using-a-320-slice-ct-scanner-in-the-diagnosis-of-mci-and-ad-patients
#6
Bo Zhang, Guo-Jun Gu, Hong Jiang, Yi Guo, Xing Shen, Bo Li, Wei Zhang
OBJECTIVES: To validate the value of whole-brain computed tomography perfusion (CTP) and CT angiography (CTA) in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). METHODS: Whole-brain CTP and four-dimensional CT angiography (4D-CTA) images were acquired in 30 MCI, 35 mild AD patients, 35 moderate AD patients, 30 severe AD patients and 50 normal controls (NC). Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and correlation between CTP and 4D-CTA were analysed...
June 2, 2017: European Radiology
https://www.readbyqxmd.com/read/28572492/beta-1-versus-beta-2-adrenergic-control-of-coronary-blood-flow-during-isometric-handgrip-exercise-in-humans
#7
Stephan R Maman, Alvaro F Vargas, Tariq Ali Ahmad, Amanda J Miller, Zhaohui Gao, Urs A Leuenberger, David N Proctor, Matthew D Muller
During exercise, β-adrenergic receptors are activated throughout the body. In healthy humans, the net effect of β-adrenergic stimulation is an increase in coronary blood flow. However, the role of vascular β1 versus β2 receptors in coronary exercise hyperemia is not clear. In this study we simultaneously measured noninvasive indices of myocardial oxygen supply (i.e., blood velocity in the left anterior descending coronary artery; Doppler echocardiography) and demand (i.e., rate pressure product; RPP = heart rate x systolic blood pressure) and tested the hypothesis that β1 blockade with esmolol improves coronary exercise hyperemia compared to nonselective β-blockade with propranolol...
June 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28522666/discrimination-between-glioma-grades-ii-and-iii-using-dynamic-susceptibility-perfusion-mri-a-meta-analysis
#8
Anna F Delgado, Alberto F Delgado
BACKGROUND: DSC perfusion has been evaluated in the discrimination between low-grade and high-grade glioma but the diagnostic potential to discriminate beween glioma grades II and III remains unclear. PURPOSE: Our aim was to evaluate the diagnostic accuracy of relative maximal CBV from DSC perfusion MR imaging to discriminate glioma grades II and III. DATA SOURCES: A systematic literature search was performed in PubMed/MEDLINE, Embase, Web of Science, and ClinicalTrials...
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28488565/evaluation-of-parametric-response-mapping-to-assess-therapeutic-response-to-human-mesenchymal-stem-cells-after-experimental-stroke
#9
Rui He, Anaïck Moisan, Olivier Detante, Chantal Rémy, Alexandre Krainik, Emmanuel Luc Barbier, Benjamin Lemasson
Stroke is the leading cause of disability in adults. After the very narrow time frame during which treatment by thrombolysis and mechanical thrombectomy is possible, cell therapy has huge potential for enhancing stroke recovery. Accurate analysis of the response to new therapy, using imaging biomarkers, is needed to assess therapeutic efficacy. The aim of this study is to compare two analysis techniques: the parametric response map (PRM), a voxel-based technique, and the standard whole-lesion approach. These two analyses were performed on data collected at 4 time points in a transient middle cerebral artery occlusion (MCAo) model, which was treated with human mesenchymal stem cell (hMSC) therapy...
May 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28481809/vessel-masked-perfusion-magnetic-resonance-imaging-with-histogram-analysis-improves-diagnostic-accuracy-for-the-grading-of-glioma
#10
Atsuko Arisawa, Yoshiyuki Watanabe, Hisashi Tanaka, Hiroto Takahashi, Chisato Matsuo, Takuya Fujiwara, Yasunori Fujimoto, Kouji Yamamoto, Noriyuki Tomiyama
OBJECTIVE: Dynamic susceptibility contrast magnetic resonance imaging is widely used to assess glioma grade; histogram analyses are used for precise tumor perfusion evaluations. We evaluated the effect of vessel contamination in normalized cerebral blood volume (nCBV) to differentiate high- and low-grade gliomas. METHODS: Thirty-four patients with gliomas underwent dynamic susceptibility contrast magnetic resonance imaging. Both traditional and vessel-masked nCBV maps were constructed...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28481312/carotid-artery-stenting-and-blood-brain-barrier-permeability-in-subjects-with-chronic-carotid-artery-stenosis
#11
Arkadiusz Szarmach, Grzegorz Halena, Mariusz Kaszubowski, Maciej Piskunowicz, Michal Studniarek, Piotr Lass, Edyta Szurowska, Pawel J Winklewski
Failure of the blood-brain barrier (BBB) is a critical event in the development and progression of diseases such as acute ischemic stroke, chronic ischemia or small vessels disease that affect the central nervous system. It is not known whether BBB breakdown in subjects with chronic carotid artery stenosis can be restrained with postoperative recovery of cerebral perfusion. The aim of the study was to assess the short-term effect of internal carotid artery stenting on basic perfusion parameters and permeability surface area-product (PS) in such a population...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28474187/idh-mutant-and-1p-19q-co-deleted-oligodendrogliomas-tumor-grade-stratification-using-diffusion-susceptibility-and-perfusion-weighted-mri
#12
Yu Lin, Zhen Xing, Dejun She, Xiefeng Yang, Yingyan Zheng, Zebin Xiao, Xingfu Wang, Dairong Cao
PURPOSE: Currently, isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion are proven diagnostic biomarkers for both grade II and III oligodendrogliomas (ODs). Non-invasive diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) are widely used to provide physiological information (cellularity, hemorrhage, calcifications, and angiogenesis) of neoplastic histology and tumor grade. However, it is unclear whether DWI, SWI, and DSC-PWI are able to stratify grades of IDH-mutant and 1p/19q co-deleted ODs...
June 2017: Neuroradiology
https://www.readbyqxmd.com/read/28461780/assessment-of-pre-and-post-operative-cerebral-perfusion-in-anterior-circulation-intracranial-aneurysm-clipping-patients-at-hospital-sungai-buloh-using-ct-perfusion-scan-and-correlations-to-fisher-navarro-and-wfns-scores
#13
Ailani Ab Ghani, Saiful Azli Mat Nayan, Regunath Kandasamy, Abdul Rahman Izani Ghani, Azmin Kass Rosman
BACKGROUND: Intracranial aneurysms may rupture and are typically associated with high morbidity and mortality, commonly due to vasospasm after rupture. Once the aneurysm ruptures, the patient's cerebral blood flow may be disturbed during the acute phase, affecting cerebral circulation and thus cerebral perfusion prior to the onset of vasospasm. Fisher and Navarro scores are used to predict vasospasm, while World Federation of Neurosurgical Societies (WFNS) scores are used to predict patient outcomes...
February 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28457859/clinical-and-radiological-assessment-of-cerebral-hemodynamics-after-cranioplasty-for-decompressive-craniectomy-a-clinical-study
#14
Perikal J Parichay, Kiran Khanapure, Krishna C Joshi, T J Aniruddha, M Sandhya, A S Hegde
OBJECTIVES: To find the correlation between radiologically proven improvement in cerebral hemodynamics with clinical improvement in patients undergoing cranioplasty. MATERIAL AND METHODS: The study is a prospective observational study of 10 cases, in M S Ramaiah Institute of Neurosciences, involving patients treated by a decompressive craniectomy for intractable intra cranial hypertension either due to trauma or stroke and afterwards underwent cranioplasty. RESULTS: Of the 10 patients, 70% patients showing significant improvement in motor functions on Barthel index scale, 60% patients showed improvement in speech, mean duration from date of decompressive craniectomy to cranioplasty being 122...
April 27, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28451938/quantitative-accuracy-of-computed-tomography-perfusion-under-low-dose-conditions-measured-using-a-hollow-fiber-phantom
#15
Kazufumi Suzuki, Hiroyuki Hashimoto, Eiji Okaniwa, Hiroshi Iimura, Shingo Suzaki, Kayoko Abe, Shuji Sakai
PURPOSE: The purpose of this study was to investigate the quantitative accuracy under low-dose conditions on computed tomography (CT) perfusion using a hollow-fiber phantom that had the theoretical absolute values of perfusion indices. MATERIALS AND METHODS: Our phantom comprised two components, i.e., a hollow-fiber hemodialyzer to pump the diluted contrast material and a surrounding syringe-shaped X-ray-absorbing body to simulate the absorption of X-rays by a brain and cranium...
April 27, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28450436/noninvasive-assessment-of-idh-mutational-status-in-world-health-organization-grade-ii-and-iii-astrocytomas-using-dwi-and-dsc-pwi-combined-with-conventional-mr-imaging
#16
Z Xing, X Yang, D She, Y Lin, Y Zhang, D Cao
BACKGROUND AND PURPOSE: Isocitrate dehydrogenase (IDH) has been shown to have both diagnostic and prognostic implications in gliomas. The purpose of this study was to examine whether DWI and DSC-PWI combined with conventional MR imaging could noninvasively predict IDH mutational status in World Health Organization grade II and III astrocytomas. MATERIALS AND METHODS: We retrospectively reviewed DWI, DSC-PWI, and conventional MR imaging in 42 patients with World Health Organization grade II and III astrocytomas...
April 27, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28441783/comparison-between-mr-perfusion-and-18f-fdg-pet-in-differentiating-tumor-recurrence-from-nonneoplastic-contrast-enhancing-tissue
#17
Yogesh Kumar, Nishant Gupta, Manisha Mangla, Kusum Hooda, Rajiv Mangla
Objective: Comparison of the accuracy of MR perfusion and 18-FDG-PET for differentiating tumor progression from nonneoplastic contrast-enhancing tissue. Methods and Materials: Retrospective review of MR perfusion and 18-FDG-PET in 23 cases of primary brain tumors (17 high grade and 6 low grade glial neoplasms) and 5 cases of metastatic lesions with enhancing lesions on post-treatment MRI was performed. The accuracy of MR perfusion versus 18-FDG-PET for distinguishing between nonneoplastic contrast-enhancing tissue and tumor recurrence was assessed...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28431614/permeability-surface-area-product-analysis-in-malignant-brain-edema-prediction-a-pilot-study
#18
O Volny, P Cimflova, T-Y Lee, B K Menon, C D d'Esterre
BACKGROUND AND PURPOSE: Using an extended CT perfusion acquisition (150s), we sought to determine the association between perfusion parameters and malignant edema after ischemic stroke. METHODS: Patients (from prospective study PROVE-IT, NCT02184936) with terminal internal carotid artery±proximal middle cerebral occlusion were involved. CTA was assessed for clot location and status of leptomeningeal collaterals. The following CTP parameters were calculated within the ischemic territory and contralaterally: permeability surface area product (PS), cerebral blood flow (CBF) and cerebral blood volume (CBV)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28424017/computed-tomography-perfusion-based-selection-of-endovascularly-treated-acute-ischaemic-stroke-patients-are-there-lessons-to-be-learned-from-the-pre-evidence-era
#19
Marios-Nikos Psychogios, Michael Knauth, Raya Bshara, Katharina Schregel, Ioannis Tsogkas, Ismini Papageorgiou, Ilko Maier, Jan Liman, Daniel Behme
Introduction Some of the latest groundbreaking trials suggest that noncontrast cranial computed tomography and computed tomography-angiography are sufficient tools for patient selection within six hours of symptom onset. Before endovascular stroke therapy became the standard of care, patient selection was one of the most useful tools to avoid futile reperfusions. We report the outcomes of endovascularly treated stroke patients selected with a perfusion-based paradigm and discuss the implications in the current era of endovascular treatment...
April 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28392326/preliminary-investigation-of-pain-related-changes-in-cerebral-blood-volume-in-patients-with-phantom-limb-pain
#20
Cheong Hoon Seo, Chang-Hyun Park, Myung Hun Jung, Soyeon Jang, So Young Joo, Yoonkyeong Kang, Suk Hoon Ohn
OBJECTIVE: We utilized MRI to measure CBV in patients who had undergone unilateral arm amputation following electrical injury to investigate changes in the pain network associated with phantom limb pain. DESIGN: Case-controlled exploratory MRI study of cerebral blood volume (CBV) via magnetic resonance imaging (MRI) SETTING: University hospital PARTICIPANTS: Ten patients with phantom limb pain following unilateral arm amputation and 16 healthy, age-matched participants...
April 6, 2017: Archives of Physical Medicine and Rehabilitation
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