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Optic nerve atrophy

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https://www.readbyqxmd.com/read/29768445/nogo-receptor-1-is-expressed-by-nearly-all-retinal-ganglion-cells
#1
Alexander M Solomon, Teleza Westbrook, Greg D Field, Aaron W McGee
A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. Inhibiting signaling by the nogo-66 receptor 1 (NgR1) promotes the re-extension of axons following a crush injury to the optic nerve, and while NgR1 mRNA and protein expression are observed in the retinal ganglion cell (RGC) layer and inner nuclear layer, which retinal cell types express NgR1 remains unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29750949/automated-beta-zone-parapapillary-area-measurement-to-differentiate-between-healthy-and-glaucoma-eyes
#2
Patricia Isabel C Manalastas, Akram Belghith, Robert N Weinreb, Jost B Jonas, Min Hee Suh, Adeleh Yarmohammadi, Felipe A Medeiros, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill
PURPOSE: To evaluate whether automated assessment of beta-zone parapapillary atrophy (ßPPA) area can differentiate between glaucomatous and healthy eyes of varying axial lengths (AL). DESIGN: Cross-sectional study. METHODS: ßPPA was automatically identified in glaucoma and healthy eyes with enhanced depth imaging optical coherence tomography (OCT) optic nerve head (ONH) radial B-scans. Associations with AL and the presence of glaucoma were assessed...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29728875/natural-history-and-clinical-characteristics-of-50-patients-with-wolfram-syndrome
#3
Gema Esteban Bueno, Dyanne Ruiz-Castañeda, Javier Ruiz Martínez, Manuel Romero Muñoz, Pedro Carrillo Alascio
PURPOSE: To describe clinical characteristics of diabetes mellitus (DM) in a group of patients with Wolfram Syndrome (WS). METHODS: Descriptive, cross-sectional observational design. The sample consisted of 50 patients diagnosed with WS. Clinical criteria contributing to WS diagnosis were analyzed: diabetes mellitus (DM), optic nerve atrophy (OA), sensorineural deafness, urological and neurological dysfunction, among others. These parameters were assessed according to their presence/absence, age of onset, and various clinical-analytical parameters...
May 4, 2018: Endocrine
https://www.readbyqxmd.com/read/29709504/the-pleiotropic-transcriptional-regulator-coup-tfi-plays-multiple-roles-in-neural-development-and-disease
#4
REVIEW
Michele Bertacchi, Josephine Parisot, Michèle Studer
Transcription factors are expressed in a dynamic fashion both in time and space during brain development, and exert their roles by activating a cascade of multiple target genes. This implies that understanding the precise function of a transcription factor becomes a challenging task. In this review, we will focus on COUP-TFI (or NR2F1), a nuclear receptor belonging to the superfamily of the steroid/thyroid hormone receptors, and considered to be one of the major transcriptional regulators orchestrating cortical arealization, cell-type specification and maturation...
April 27, 2018: Brain Research
https://www.readbyqxmd.com/read/29670766/corneal-debridement-combined-with-intrastromal-voriconazole-for-recalcitrant-fungal-keratitis
#5
Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng
Background: To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. Methods: This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50  μ g/0.1 ml). This paper reviews and analyzes the patients' basic state, surgical intervention, medicinal treatment, and outcomes. Results: The mean sizes of infiltration and ulcer were (5...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29667428/optical-coherence-tomography-angiography-characterization-of-acute-and-late-stage-purtscher-retinopathy
#6
Pedro Gil, Miguel Raimundo, João P Marques, João Póvoa, Rufino Silva
PURPOSE: To report a case of Purtscher retinopathy imaged with optical coherence tomography angiography. METHODS: Case-report. Left eye fundoscopic examination in a 21-year old male after a road traffic accident with chest compression revealed multiple peri-papillary cotton-wool spots and intra- and pre-retinal hemorrhages. A diagnosis of Purtscher retinopathy was assumed. RESULTS: In both the superficial and deep retinal plexuses, acute stage optical coherence tomography angiography identified multiple irregular areas of capillary non-perfusion that extended beyond the clinically visible peri-papillary cotton-wool spots...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664921/predictors-of-vision-impairment-in-multiple-sclerosis
#7
Bernardo Sanchez-Dalmau, Elena H Martinez-Lapiscina, Irene Pulido-Valdeolivas, Irati Zubizarreta, Sara Llufriu, Yolanda Blanco, Nuria Sola-Valls, Maria Sepulveda, Ana Guerrero, Salut Alba, Magi Andorra, Anna Camos, Laura Sanchez-Vela, Veronica Alfonso, Albert Saiz, Pablo Villoslada
Visual impairment significantly alters the quality of life of people with Multiple Sclerosis (MS). The objective of this study was to identify predictors (independent variables) of visual outcomes, and to define their relationship with neurological disability and retinal atrophy when assessed by optical coherence tomography (OCT). We performed a cross-sectional analysis of 119 consecutive patients with MS, assessing vision using high contrast visual acuity (LogMar), 2.5% and 1.25% low contrast visual acuity (Sloan charts), and color vision (Hardy-Rand-Rittler plates)...
2018: PloS One
https://www.readbyqxmd.com/read/29659412/photodynamic-therapy-as-primary-treatment-for-small-choroidal-melanoma
#8
Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields
PURPOSE: To report outcomes of photodynamic therapy (PDT) as primary treatment for small amelanotic choroidal melanoma. METHODS: Retrospective interventional case series of 12 patients with small choroidal melanoma treated with standard-fluence PDT (83 seconds; 50 J/cm) using verteporfin. OUTCOME MEASURES: Tumor regression, subretinal fluid resolution, best-corrected visual acuity, and PDT complications. RESULTS: There were 12 eyes with melanoma, demonstrating amelanotic (10 [83%]) or lightly pigmented (n = 2, 17%) appearance...
April 13, 2018: Retina
https://www.readbyqxmd.com/read/29627627/postoperative-posterior-ischemic-optic-neuropathy-a-left-far-lateral-craniectomy-for-resection-of-craniocervical-meningioma
#9
Ilyas M Eli, Robert B Kim, Craig Kilburg, Travis J Pecha, William T Couldwell, Sarah T Menacho
BACKGROUND: Postoperative posterior ischemic optic neuropathy (PION) is a rare cause of postoperative vision loss, most often seen when surgical patients are placed in the prone position for a prolonged period of time. The authors report a case of bilateral PION after a far-lateral craniectomy in the lateral position. CASE DESCRIPTION: A 36-year-old man with a history of right extremity numbness, weakness, and muscle atrophy was discovered to have a craniocervical meningioma...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29599249/acute-retinal-toxicity-associated-with-a-mixture-of-perfluorooctane-and-perfluorohexyloctane-failure-of-another-indirect-cytotoxicity-analysis
#10
Rosa M Coco, Girish K Srivastava, Cristina Andrés-Iglesias, Jesús Medina, Fernando Rull, Alvaro Fernandez-Vega-Gonzalez, Ivan Fernandez-Bueno, Antonio Dueñas, Jose C Pastor
AIMS: To report new information related to acute retinal toxicity of Bio Octane Plus, a mixture of 90% perfluorooctane (PFO) and 10% perfluorohexyloctane. METHODS: This retrospective, descriptive case series reports the occurrence of acute retinal toxicity after vitreoretinal surgery in which Bio Octane Plus (batch number 1605148) was used as an endotamponade. Cytotoxicity biocompatibility tests and chemical analyses by Fourier-transformed infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) of the presumed toxic product were performed...
March 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29588904/endoscopic-endonasal-approach-for-complex-macroadenoma-with-suprasellar-and-retrochiasmatic-extension
#11
Edinson Najera, Carl H Snyderman, Juan C Fernandez-Miranda
In this video, we describe the technical nuances of an endoscopic endonasal approach (EEA) for a complex macroadenoma with suprasellar and retrochiasmatic extension. The patient is a 51-year-old male with several years' history of progressive visual loss. Neuro-ophthalmology assessment revealed a profound visual loss with homonymous hemianopsia and left optic nerve atrophy. His pituitary hormonal profile was normal. The options for surgical approach included transcranial, endoscopic endonasal, or a combination of both...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29571856/software-updates-of-oct-segmentation-algorithms-influence-longitudinal-assessment-of-retinal-atrophy
#12
Danko Coric, Axel Petzold, Bernard M J Uitdehaag, Lisanne J Balk
OBJECTIVE: To investigate whether there is a systematic difference in peripapillary retinal nerve fiber layer (pRNFL) thickness measurements between subsequent updates of pRNFL segmentation software provided by Heidelberg Spectralis optical coherence tomography (OCT). METHODS: In total, 838 pRNFL scans from 213 multiple sclerosis (MS) patients and 61 healthy controls were analyzed. All scans were performed on the same OCT device followed by automated segmentation (HRA 5...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29564662/can-optical-coherence-tomography-be-used-to-guide-treatment-decisions-in-adult-or-pediatric-multiple-sclerosis
#13
REVIEW
Jeffrey Lambe, Olwen C Murphy, Shiv Saidha
PURPOSE OF REVIEW: With the recognition that neurodegeneration represents the principal substrate of disability in multiple sclerosis (MS), there has been increased strives towards identifying biomarkers for accurately quantifying and tracking neurodegeneration during the disease course. The retina provides an opportune "window" into the central nervous system (CNS) in MS, with retinal changes in MS reflecting not only local, but also global aspects of neurodegeneration and inflammation operative in the disease...
March 21, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29550000/longitudinal-changes-of-optic-nerve-head-and-peripapillary-structure-during-childhood-myopia-progression-on-oct-boramae-myopia-cohort-study-report-1
#14
Martha Kim, Ho-Kyung Choung, Kyoung Min Lee, Sohee Oh, Seok Hwan Kim
PURPOSE: To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy children with myopia (46 eyes). METHODS: The participants underwent fundus photography, SD OCT, and axial length (AXL) measurements every 6 months for 2 years...
March 14, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29520613/in-vivo-exploration-of-retinal-nerve-fiber-layer-morphology-in-parkinson-s-disease-patients
#15
Femke Visser, Koenraad A Vermeer, Babak Ghafaryasl, Annemarie M M Vlaar, Valentin Apostolov, Jan van Hellenberg Hubar, Henry C Weinstein, Johannes F de Boer, Henk W Berendse
Thinning of the retinal nerve fiber layer (RNFL) is a recently discovered feature of Parkinson's disease (PD). Its exact pathological mechanism is yet unknown. We aimed to determine whether morphological changes of the RNFL are limited to RNFL thinning or also comprise an altered internal structure of this layer. Therefore, we investigated RNFL thickness and applied the RNFL attenuation coefficient (RNFL-AC), a novel method derived from optical coherence tomography, in PD patients and healthy controls (HCs)...
March 8, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29516048/the-importance-of-ganglion-cell-complex-investigation-in-myopic-patients
#16
Maria Veronica Strehaianu, Dana Dascalescu, Catalina Ionescu, Miruna Burcel, Vasile Potop, Catalina Corbu
Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickness. However, due to disc tilting and peripapillary atrophy, the RNFL evaluation may be prone to errors in myopic patients...
October 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29514678/early-alpha-lipoic-acid-therapy-protects-from-degeneration-of-the-inner-retinal-layers-and-vision-loss-in-an-experimental-autoimmune-encephalomyelitis-optic-neuritis-model
#17
Michael Dietrich, Niklas Helling, Alexander Hilla, Annemarie Heskamp, Andrea Issberner, Thomas Hildebrandt, Zippora Kohne, Patrick Küry, Carsten Berndt, Orhan Aktas, Dietmar Fischer, Hans-Peter Hartung, Philipp Albrecht
BACKGROUND: In multiple sclerosis (MS), neurodegeneration is the main reason for chronic disability. Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS. However, it remains uncertain if it is also beneficial in the early, more inflammatory-driven phases. As clinical studies are costly and time consuming, optic neuritis (ON) is often used for investigating neuroprotective or regenerative therapeutics...
March 7, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29503945/atypical-tolosa-hunt-syndrome-with-bilateral-sclerokeratitis-and-optic-atrophy-in-takayasu-s-arteritis
#18
Kalpana Babu, Deepika C Parameswarappa
Purpose: We report an interesting case of atypical Tolosa Hunt syndrome with bilateral Sclerokeratitis and optic atrophy in a patient with Takayasu's arteritis. Observations: A 31-year- old lady presented with severe retroorbital pain in the right eye and right sided headache of 2 weeks duration. She had a history of 6th and 7th nerve palsies which improved with oral corticosteroids. Her BCVA was no perception of light in OD and 6/6 in OS. Slitlamp examination showed bilateral old sclerokeratitis and fundus examination showed bilateral optic atrophy...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29503938/simultaneous-central-retinal-artery-occlusion-and-optic-nerve-vasculitis-in-crohn-disease
#19
Razek Georges Coussa, Andre Ali-Ridha, Natalia Vila, Rayan Alshareef, John Chen
Purpose: To describe a case of Crohn disease presenting as occlusive vasculitis resulting in a central retinal artery occlusion (CRAO) in one eye and transient ischemic optic neuropathy in the fellow eye. Observations: An 18-year-old patient recently diagnosed with biopsy-proven Crohn disease presented with CRAO OD after a previous episode of transient visual loss OS. Extensive workup was negative for other autoimmune or infectious etiologies. The patient was started on intravenous methylprednisolone for 72 h followed by maintenance dose of azathioprine and oral prednisone...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29492085/clinical-relationship-between-auditory-neuropathy-and-nervous-system-diseases
#20
Jingbo Wang, Lanlan Jin, Jun Chen, Xiaobi Fang, Zhisu Liao
Objective: To explore the clinical relationship between auditory neuropathy (AN) and nervous system diseases. Methods: A total of 134 AN patients who were treated in our hospital from December 2011 to April 2016 were selected. Then 120 cases (240 ears) with complete data of pure tone audiometry and acoustic immittance test were selected as an AN1 group, which was compared with 30 patients (49 ears) with general sensorineural hearing loss (SHL) in regard to the results of pure tone audiometry and acoustic immittance test...
November 2017: Pakistan Journal of Medical Sciences Quarterly
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