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https://www.readbyqxmd.com/read/27892721/social-aspects-in-additive-manufacturing-of-pharmaceutical-products
#1
Johanna Lind, Sofia Kälvemark Sporrong, Susanne Kaae, Jukka Rantanen, Natalja Genina
Additive manufacturing (AM) techniques, such as drug printing, represent a new engineering approach that can implement the concept of personalized medicine via on-demand manufacturing of dosage forms with individually adjusted doses. Implementation of AM principles, such as pharmacoprinting, will challenge the entire drug distribution chain and affect the society at different levels. Areas covered: This work summarizes the concept of personalized medicine and gives an overview of possibilities for monitoring patients' health...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27845476/are-liquids-an-efficient-vehicle-of-healthcare-associated-infections-a-review-of-reported-cases-in-italy-2000-2014
#2
D D'Alessandro, A Nusca, C Napoli
INTRODUCTION: In the field of healthcare-associated infections (HCAIs), one of the most reported, studied and discussed sources of infections is water, partly due to its controllability, but also because healthcare facilities, especially hospitals, require a significant quantity of water per day. In addition to water, during healthcare procedures, other liquids can serve as source of infections. The present study reports a review of those HCAIs associated to liquid vehicles occurred in Italy during the period 2000-2014...
November 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/27834123/translational-applications-of-tissue-engineering-in-cardiovascular-medicine
#3
Y Murat Elçin, Arin Dogan, Eser Elçin
Cardiovascular diseases are the leading cause of worldwide deaths. Current paradigm in medicine seeks novel approaches for the treatment of progressive or end-stage diseases. The organ transplantation option is limited in availability and unfortunately, a great number of patients are lost while waiting for donor organs. Animal studies have shown that upon myocardial infarction, it may be possible to stop adverse remodeling in its tracks and reverse with tissue engineering methods. Regaining the myocardium function and avoiding further deterioration towards heart failure can benefit millions of people with a significantly lesser burden on healthcare systems worldwide...
November 11, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27830239/human-factors-for-more-usable-and-safer-health-information-technology-where-are-we-now-and-where-do-we-go-from-here
#4
A Kushniruk, C Nohr, E Borycki
: A wide range of human factors approaches have been developed and adapted to healthcare for detecting and mitigating negative unexpected consequences associated with technology in healthcare (i.e. technology-induced errors). However, greater knowledge and wider dissemination of human factors methods is needed to ensure more usable and safer health information technology (IT) systems. OBJECTIVE: This paper reports on work done by the IMIA Human Factors Working Group and discusses some successful approaches that have been applied in using human factors to mitigate negative unintended consequences of health IT...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27828732/economics-of-ramucirumab-for-metastatic-colorectal-cancer
#5
Simon B Zeichner, Christine G Kohn, Daniel A Goldstein
Introduction Despite its FDA approval and incorporation into the National Comprehensive Cancer Network (NCCN) treatment guidelines, ramucirumab (RAM) is associated with a drug acquisition cost that is substantially higher than other approved options. Given its substantial cost, the presence of a viable alternative treatment option, and its minimal survival improvement, the usefulness of RAM in clinical practice has been called into question. Areas covered In this paper, we outline the cost, benefits, and economic implications of RAM from a US perspective, as it is used in the treatment of mCRC...
November 9, 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27808064/use-of-speech-to-text-technology-for-documentation-by-healthcare-providers
#6
REVIEW
Sima Ajami
Medical records are a critical component of a patient's treatment. However, documentation of patient-related information is considered a secondary activity in the provision of healthcare services, often leading to incomplete medical records and patient data of low quality. Advances in information technology (IT) in the health system and registration of information in electronic health records (EHR) using speechto- text conversion software have facilitated service delivery. This narrative review is a literature search with the help of libraries, books, conference proceedings, databases of Science Direct, PubMed, Proquest, Springer, SID (Scientific Information Database), and search engines such as Yahoo, and Google...
May 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/27807814/the-european-network-of-coloproctology-a-strategy-towards-the-european-research-and-healthcare-system
#7
Michele Rubbini
Many documents from the International Institutions point out that Health represents an engine of economic and social development. Based on these documents and concepts, the European Parliament decided to create a system of European Reference Networks as a synthesis of clinical and research activities, particularly in the field of rare diseases. This initiative, properly implemented, could be first step towards a new European health system. This article instead, wanting to deepen this perspective, postulates that the ERNs may also be related to widespread diseases, such as those of coloproctological interest, with the aim of setting up a European Network of Coloproctology (ENCP)...
December 2016: Updates in Surgery
https://www.readbyqxmd.com/read/27756716/strengthening-interprofessional-requirements-engineering-through-action-sheets-a-pilot-study
#8
Aline Kunz, Sabrina Pohlmann, Oliver Heinze, Antje Brandner, Christina Reiß, Martina Kamradt, Joachim Szecsenyi, Dominik Ose
BACKGROUND: The importance of information and communication technology for healthcare is steadily growing. Newly developed tools are addressing different user groups: physicians, other health care professionals, social workers, patients, and family members. Since often many different actors with different expertise and perspectives are involved in the development process it can be a challenge to integrate the user-reported requirements of those heterogeneous user groups. Nevertheless, the understanding and consideration of user requirements is the prerequisite of building a feasible technical solution...
October 18, 2016: JMIR Human Factors
https://www.readbyqxmd.com/read/27703622/a-first-step-toward-understanding-patient-safety
#9
Kyoung Ok Kim
Patient safety has become an important policy agenda in healthcare systems since publication of the 1999 report entitled "To Err Is Human." The paradigm has changed from blaming the individual for the error to identifying the weakness in the system that led to the adverse events. Anesthesia is one of the first healthcare specialties to adopt techniques and lessons from the aviation industry. The widespread use of simulation programs and the application of human factors engineering to clinical practice are the influences of the aviation industry...
October 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27640245/current-advances-in-electrospun-gelatin-based-scaffolds-for-tissue-engineering-applications
#10
Ana A Aldana, Gustavo A Abraham
The development of biomimetic highly-porous scaffolds is essential for successful tissue engineering. Electrospun nanofibers are highly versatile platforms for a broad range of applications in different research areas. In the biomedical field, micro/nanoscale fibrous structures have gained great interest for wound dressings, drug delivery systems, soft and hard-tissue engineering scaffolds, enzyme immobilization, among other healthcare applications. In this mini-review, electrospun gelatin-based scaffolds for a variety of tissue engineering applications, such as bone, cartilage, skin, nerve, and ocular and vascular tissue engineering, are reviewed and discussed...
September 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27632024/additive-manufacturing-of-biomaterials-tissues-and-organs
#11
Amir A Zadpoor, Jos Malda
The introduction of additive manufacturing (AM), often referred to as three-dimensional (3D) printing, has initiated what some believe to be a manufacturing revolution, and has expedited the development of the field of biofabrication. Moreover, recent advances in AM have facilitated further development of patient-specific healthcare solutions. Customization of many healthcare products and services, such as implants, drug delivery devices, medical instruments, prosthetics, and in vitro models, would have been extremely challenging-if not impossible-without AM technologies...
September 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27626610/adaptive-biomedical-innovation-evolving-our-global-system-to-sustainably-and-safely-bring-new-medicines-to-patients-in-need
#12
G Hirsch, M Trusheim, E Cobbs, M Bala, S Garner, D Hartman, K Isaacs, M Lumpkin, R Lim, K Oye, E Pezalla, P Saltonstall, H Selker
The current system of biomedical innovation is unable to keep pace with scientific advancements. We propose to address this gap by reengineering innovation processes to accelerate reliable delivery of products that address unmet medical needs. Adaptive biomedical innovation (ABI) provides an integrative, strategic approach for process innovation. Although the term "ABI" is new, it encompasses fragmented "tools" that have been developed across the global pharmaceutical industry, and could accelerate the evolution of the system through more coordinated application...
September 14, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27616964/integrated-health-care-barcelona-esquerra-ais-be-a-global-view-of-organisational-development-re-engineering-of-processes-and-improvement-of-the-information-systems-the-role-of-the-tertiary-university-hospital-in-the-transformation
#13
David Font, Joan Escarrabill, Mónica Gómez, Rafael Ruiz, Belén Enfedaque, Xavier Altimiras
The Integrated Health Area "Barcelona Esquerra" (Área Integral de Salud de Barcelona Esquerra - AIS-BE), which covers a population of 524,000 residents in Barcelona city, is running a project to improve healthcare quality and efficiency based on co-ordination between the different suppliers in its area through the participation of their professionals. Endowed with an Organisational Model that seeks decision-taking that starts out from clinical knowledge and from Information Systems tools that facilitate this co-ordination (an interoperability platform and a website) it presents important results in its structured programmes that have been implemented such as the Reorganisation of Emergency Care, Screening for Colorectal Cancer, the Onset of type 2 Diabetes Mellitus, Teledermatology and the Development of Cross-sectional Healthcare Policies for Care in Chronicity...
2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/27596486/embalance-validation-of-a-decision-support-system-in-the-early-diagnostic-evaluation-and-management-plan-formulation-of-balance-disorders-in-primary-care-study-protocol-of-a-feasibility-randomised-controlled-trial
#14
Laura Rammazzo, Dimitris Kikidis, Amal Anwer, Nora Macdonald, Efthymios Kyrodimos, Christoph Maurer, Floris Wuyts, Linda Luxon, Athanasios Bibas, Doris-Eva Bamiou
BACKGROUND: Balance problems are caused by multiple factors and often lead to falls and related fractures, bringing large socio-economic costs. The complexity of balance control mechanisms, the lack of medical expertise, and the absence of specialised equipment contribute to the delayed or incorrect diagnosis and management ofthese patients. Advances in computer science have allowed the development of computer systems that support clinical diagnosis and treatment decisions based on individualised patient data...
2016: Trials
https://www.readbyqxmd.com/read/27561754/a-multimodal-search-engine-for-medical-imaging-studies
#15
Eduardo Pinho, Tiago Godinho, Frederico Valente, Carlos Costa
The use of digital medical imaging systems in healthcare institutions has increased significantly, and the large amounts of data in these systems have led to the conception of powerful support tools: recent studies on content-based image retrieval (CBIR) and multimodal information retrieval in the field hold great potential in decision support, as well as for addressing multiple challenges in healthcare systems, such as computer-aided diagnosis (CAD). However, the subject is still under heavy research, and very few solutions have become part of Picture Archiving and Communication Systems (PACS) in hospitals and clinics...
August 25, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27516677/non-drug-therapy-and-prevention-of-diabetes-mellitus-by-dalk-massage
#16
Davood Bayat, Seyed Reza Vakilinia, Majid Asghari
BACKGROUND: According to WHO estimation, the number of diabetic patients would reach about 591.9 million people in 2035. The tendency towards other kinds of treatment is increasing because of the high therapeutic expenditures and current medical complications. Positive results of massage in recent articles and the prominent role of dalk in Iranian traditional medicine led us to the present study review. METHODS: Studying Iranian traditional medicine textbooks, such as Canon of Ibn Sina, Kholasat Al Hekma of Aghili, Zakhireh-ye Khwarazm shahi of Jorjani, Alhavi of Razes and Kamel-al-sanaat of Ibn Abas were done on the topic of dalk discussion...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27515388/histological-response-of-soda-lime-glass-ceramic-bactericidal-rods-implanted-in-the-jaws-of-beagle-dogs
#17
José S Moya, Arturo Martínez, Roberto López-Píriz, Francisco Guitián, Luis A Díaz, Leticia Esteban-Tejeda, Belén Cabal, Federico Sket, Elisa Fernández-García, Antoni P Tomsia, Ramón Torrecillas
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod...
August 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27515102/cost-of-heart-failure-management-in-turkey-results-of-a-delphi-panel
#18
Dursun Aras, Sinan Aydoğdu, Engin Bozkurt, Yüksel Çavuşoğlu, Mehmet Eren, Çetin Erol, Sadi Güleç, Pınar Kızılırmak, Zeki Öngen, Oktay Özdemir, Mete Saylan, Lale Tokgözoğlu, Ekrem Yeter, Mehmet Birhan Yılmaz
OBJECTIVE: To analyze health-related cost of heart failure (HF) and to evaluate health-related source utilization aiming to provide data on the economic burden of HF in actual clinical practice in Turkey. METHODS: The study used the Delphi process of seeking expert consensus of opinion including 11 cardiologists who are experienced in HF. The standardized questionnaire comprised items to reflect the opinion of the expert panelists on the distribution of the HF patients in terms of demographic and clinical characteristics and background disease states...
August 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27472942/does-performance-based-financing-increase-value-for-money-in-low-and-middle-income-countries-a-systematic-review
#19
REVIEW
Anne-Marie Turcotte-Tremblay, Jessica Spagnolo, Manuela De Allegri, Valéry Ridde
Governments of low- and middle-income countries (LMICs) are widely implementing performance-based financing (PBF) to improve healthcare services. However, it is unclear whether PBF provides good value for money compared to status quo or other interventions aimed at strengthening the healthcare system in LMICs. The objective of this systematic review is to identify and synthesize the existing literature that examines whether PBF represents an efficient manner of investing resources. We considered PBF to be efficient when improved care quality or quantity was achieved with equal or lower costs, or alternatively, when the same quality of care was achieved using less financial resources...
December 2016: Health Economics Review
https://www.readbyqxmd.com/read/27448800/management-of-ventilator-associated-pneumonia-in-intensive-care-units-a-mixed-methods-study-assessing-barriers-and-facilitators-to-guideline-adherence
#20
Nasia Safdar, Jackson S Musuuza, Anping Xie, Ann Schoofs Hundt, Matthew Hall, Kenneth Wood, Pascale Carayon
BACKGROUND: Guidelines from the Infectious Diseases Society of America/The American Thoracic Society (IDSA/ATS) provide recommendations for diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the mere presence of guidelines is rarely sufficient to promote widespread adoption and uptake. Using the Systems Engineering Initiative for Patient Safety (SEIPS) model framework, we undertook a study to understand barriers and facilitators to the adoption of the IDSA/ATS guidelines...
2016: BMC Infectious Diseases
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