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https://www.readbyqxmd.com/read/28445263/acupuncture-for-enhancing-early-recovery-of-bowel-function-in-cancer-protocol-for-a-systematic-review
#1
Yi-Hua Liu, Yang Ye, Jia-Bin Zheng, Xue-Qian Wang, Ying Zhang, Hong-Sheng Lin
BACKGROUND: Cancer patients undergoing surgical procedure often suffer from bowel dysfunction and postoperative ileus (POI). Cancer management for early recovery of bowel function is still a challenging topic. Acupuncture has been commonly used in a variety of gastrointestinal diseases. The aim of this study is to evaluate the effects of acupuncture therapy to reduce the duration of POI and enhance bowel function in cancer patients. METHODS: We will systematically screen all randomized controlled trials (RCTs) published through electronically and hand searching...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441473/assembly-of-macrocycle-dye-derivatives-into-particles-for-fluorescence-and-photoacoustic-applications
#2
Hoang Dung Lu, Tristan L Lim, Shoshana Javitt, Andrew Heinmiller, Robert K Prud'homme
Optical imaging is a rapidly progressing medical technique that can benefit from the development of new and improved optical imaging agents suitable for use in vivo. However, the molecular rules detailing what optical agents can be processed and encapsulated into in vivo presentable forms are not known. We here present the screening of series of highly hydrophobic porphyrin, phthalocyanine, and naphthalocyanine dye macrocycles through a self-assembling Flash NanoPrecipitation process to form a series of water dispersible dye nanoparticles (NPs)...
April 25, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28440839/refugee-health-and-rehabilitation-challenges-and-response
#3
Fary Khan, Bhasker Amatya
BACKGROUND: The current global refugee crisis poses major challenges in providing effective healthcare to refugees, particularly for non-communicable diseases (NCDs) management and disability. This article provides an overview of refugee health and potential challenges from the rehabilitation perspective. METHODS: A literature search (both academic and grey literature) was conducted using medical and health science electronic databases and internet search engines (2001-2016)...
April 21, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28439751/development-of-a-streamlined-work-flow-for-handling-patients-genetic-testing-insurance-authorizations
#4
Wendy R Uhlmann, Katie Schwalm, Victoria M Raymond
Obtaining genetic testing insurance authorizations for patients is a complex, time-involved process often requiring genetic counselor (GC) and physician involvement. In an effort to mitigate this complexity and meet the increasing number of genetic testing insurance authorization requests, GCs formed a novel partnership with an industrial engineer (IE) and a patient services associate (PSA) to develop a streamlined work flow. Eight genetics clinics and five specialty clinics at the University of Michigan were surveyed to obtain benchmarking data...
April 24, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28437511/online-information-on-the-treatment-of-burning-mouth-syndrome-quality-and-readability
#5
Shatha Alnafea, Stefano Fedele, Stephen Porter, Richeal Ni Riordain
AIMS: To evaluate the quality and readability of online information about the treatment of burning mouth syndrome (BMS). METHODS: An internet search using the phrase "burning mouth syndrome treatment" was carried out on the Google search engine (www.google.co.uk) on 8 June 2015, and the first 100 websites listed were examined. Data collection included DISCERN score, the Journal of the American Medical Association (JAMA) benchmarks for website analysis score, the presence of the Health on the Net (HON) Foundation seal, and the Flesch Reading Ease Score (FRES)...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28436649/multi-arm-junctions-for-dynamic-dna-nanotechnology
#6
Shohei Kotani, William L Hughes
Non-enzymatic catalytic substrates have been engineered using toehold-mediated DNA strand displacement, and their programmable applications range from medical diagnosis to molecular computation. However, the complexity, stability, scalability, and sensitivity of those systems are plagued by network leakage. A novel way to suppress leakage is to increase its energy barrier through four-way branch migration. Presented here, we designed multi-arm junction substrates that simultaneously exploit four-way branch migration, with a high-energy barrier to minimize leakage, and three-way branch migration, with a low energy barrier to maximize catalysis...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28436377/analysis-of-therapeutic-effectiveness-of-selected-types-of-collagen-in-prevention-and-treatment-of-degenerative-joint-disease
#7
Wiesław Tomaszewski, Anna Paradowska
Loss of collagen is a natural development accompanying aging of the body. It may be additionally accelerated by various conditions, including osteoarthritis (OA). Within the last two decades numerous and diverse studies have been conducted worldwide with the aim of identifying substances containing collagen, producing therapeutic preparations of expected effectiveness in the prevention and therapy of OA that would be safe to use and developing methods of delivering the final product into the body. The authors reviewed and analysed the latest available literature by selecting papers presenting the findings of studies conducted in line with the principles of Evidence-Based Medicine (EBM)...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28435492/applying-systems-engineering-reduces-radiology-transport-cycle-times-in-the-emergency-department
#8
Benjamin A White, Brian J Yun, Michael H Lev, Ali S Raja
INTRODUCTION: Emergency department (ED) crowding is widespread, and can result in care delays, medical errors, increased costs, and decreased patient satisfaction. Simultaneously, while capacity constraints on EDs are worsening, contributing factors such as patient volume and inpatient bed capacity are often outside the influence of ED administrators. Therefore, systems engineering approaches that improve throughput and reduce waste may hold the most readily available gains. Decreasing radiology turnaround times improves ED patient throughput and decreases patient waiting time...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28433146/chemo-bacterial-synthesis-of-conjugatable-glycosaminoglycans
#9
Bernard Priem, Julien Peroux, Philippe Colin-Morel, Sophie Drouillard, Sébastien Fort
Conjugatable glycosaminoglycans hold promise for medical applications involving the vectorization of specific molecules. Here, we set out to produce bacterial chondroitin and heparosan from a conjugatable precursor using metabolically engineered Escherichia coli strains. The major barrier to this procedure was the glucuronylation of a lactosyl acceptor required for polymerization. To overcome this barrier, we designed E. coli strains expressing mouse β-1,3-glucuronyl transferase and E. coli K4 chondroitin and K5 heparosan synthases...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28432642/emerging-use-of-early-health-technology-assessment-in-medical-product-development-a-scoping-review-of-the-literature
#10
REVIEW
Maarten J IJzerman, Hendrik Koffijberg, Elisabeth Fenwick, Murray Krahn
Early health technology assessment is increasingly being used to support health economic evidence development during early stages of clinical research. Such early models can be used to inform research and development about the design and management of new medical technologies to mitigate the risks, perceived by industry and the public sector, associated with market access and reimbursement. Over the past 25 years it has been suggested that health economic evaluation in the early stages may benefit the development and diffusion of medical products...
April 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28431803/reutilization-of-discarded-biomass-for-preparing-functional-polymer-materials
#11
REVIEW
Jianfeng Wang, Wenzhen Qian, Yufeng He, Yubing Xiong, Pengfei Song, Rong-Min Wang
Biomass is abundant and recyclable on the earth, which has been assigned numerous roles to human beings. However, over the past decades, accompanying with the rapid expansion of man-made materials, such as alloy, plastic, synthetic rubber and fiber, a great number of natural materials had been neglected and abandoned, such as straw, which cause a waste of resource and environmental pollution. In this review, based on introducing sources of discarded biomass, the main composition and polymer chains in discarded biomass materials, the traditional treatment and novel approach for reutilization of discarded biomass were summarized...
April 18, 2017: Waste Management
https://www.readbyqxmd.com/read/28429809/successful-pegylation-of-hollow-encapsulin-nanoparticles-from-rhodococcus-erythropolis-n771-without-affecting-their-disassembly-and-reassembly-properties
#12
Seiichi Sonotaki, Taku Takami, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Yoshihiko Murakami
We developed a hollow PEGylated encapsulin nanoparticle from Rhodococcus erythropolis N771. The hollow engineered encapsulin nanoparticles with His-Tag and Lys residues on the surface were constructed by means of genetic recombination. The Lys residues on the particle surface were successfully PEGylated with a PEG derivative, methoxy-PEG-SCM. Consequently, we demonstrated that the hollow PEGylated engineered encapsulin nanoparticle could successfully disassemble or reassemble even after PEGylation in the presence or absence of a protein denaturing agent...
April 21, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28425205/engineering-the-xylose-catabolizing-dahms-pathway-for-production-of-poly-d-lactate-co-glycolate-and-poly-d-lactate-co-glycolate-co-d-2-hydroxybutyrate-in-escherichia-coli
#13
So Young Choi, Won Jun Kim, Seung Jung Yu, Si Jae Park, Sung Gap Im, Sang Yup Lee
Poly(lactate-co-glycolate), PLGA, is a representative synthetic biopolymer widely used in medical applications. Recently, we reported one-step direct fermentative production of PLGA and its copolymers by metabolically engineered Escherichia coli from xylose and glucose. In this study, we report development of metabolically engineered E. coli strains for the production of PLGA and poly(d-lactate-co-glycolate-co-d-2-hydroxybutyrate) having various monomer compositions from xylose as a sole carbon source. To achieve this, the metabolic flux towards Dahms pathway was modulated using five different synthetic promoters for the expression of Caulobacter crescentus XylBC...
April 19, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28423844/identifying-emerging-trends-in-medical-informatics-a-synthesis-approach
#14
Yasmin Van Kasteren, Patricia A H Williams, Anthony Maeder
Medical informatics is a young and rapidly evolving field, influenced by and impacting on many different knowledge domains. Recent contributions on scoping the associated body of knowledge are confounded both by variations in popular use of terminology for established areas, and by the advent of new areas without yet established terminology. Determining the scope of a topic through online bibliographic search filters is a well-established approach in scientific research and has been developed as a human-directed task...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423815/mobile-medical-apps-and-mhealth-devices-a-framework-to-build-medical-apps-and-mhealth-devices-in-an-ethical-manner-to-promote-safer-use-a-literature-review
#15
Mary Sharp, Declan O'Sullivan
This paper presents a preliminary literature review in the area of ethics in the development of Mobile Medical Apps and mHealth. The review included both direct health apps and also apps marketed under the area of well-being in addition to mHealth devices. The following words and combinations of them were used to carry out the search for publications, mHealth, Apps, Ethics. The search engines used were Google Scholar, and PubMed. The paper is restricted to publications since 2012. The total number of papers found was 1,920 of which 84 were reviewed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423767/querying-ehrs-with-a-semantic-and-entity-oriented-query-language
#16
Romain Lelong, Lina Soualmia, Badisse Dahamna, Nicolas Griffon, Stéfan J Darmoni
While the digitization of medical documents has greatly expanded during the past decade, health information retrieval has become a great challenge to address many issues in medical research. Information retrieval in electronic health records (EHR) should also reduce the difficult tasks of manual information retrieval from records in paper format or computer. The aim of this article was to present the features of a semantic search engine implemented in EHRs. A flexible, scalable and entity-oriented query language tool is proposed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28416139/cars-synthetic-immunoreceptors-for-cancer-therapy-and-beyond
#17
REVIEW
ZeNan L Chang, Yvonne Y Chen
Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy...
April 13, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28415427/surface-physical-chemistry-properties-in-coated-bacterial-cellulose-membranes-with-calcium-phosphate
#18
Gabriel Molina de Olyveira, Pierre Basmaji, Ligia Maria Manzine Costa, Márcio Luiz Dos Santos, Carla Dos Santos Riccardi, Fernando Pozzi Semeghini Guastaldi, Raquel Mantuaneli Scarel-Caminaga, Ticiana Sidorenko de Oliveira Capote, Elisabeth Pizoni, Antônio Carlos Guastaldi
Bacterial cellulose has become established as a new biomaterial, and it can be used for medical applications. In addition, it has called attention due to the increasing interest in tissue engineering materials for wound care. In this work, the bacterial cellulose fermentation process was modified by the addition of chondroitin sulfate to the culture medium before the inoculation of the bacteria. The biomimetic process with heterogeneous calcium phosphate precipitation of biological interest was studied for the guided regeneration purposes on bacterial cellulose...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413132/development-of-an-intradermal-dna-vaccine-delivery-strategy-to-achieve-single-dose-immunity-against-respiratory-syncytial-virus
#19
Trevor R F Smith, Katherine Schultheis, Matthew P Morrow, Kimberly A Kraynyak, Jay R McCoy, Kevin C Yim, Karuppiah Muthumani, Laurent Humeau, David B Weiner, Niranjan Y Sardesai, Kate E Broderick
Respiratory syncytial virus (RSV) is a massive medical burden in infants, children and the elderly worldwide, and an effective, safe RSV vaccine remains an unmet need. Here we assess a novel vaccination strategy based on the intradermal delivery of a SynCon® DNA-based vaccine encoding engineered RSV-F antigen using a surface electroporation device (SEP) to target epidermal cells, in clinically relevant experimental models. We demonstrate the ability of this strategy to elicit robust immune responses. Importantly we demonstrate complete resistance to pulmonary infection at a single low dose of vaccine in the cotton rat RSV/A challenge model...
April 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28410982/ehr-based-phenotyping-bulk-learning-and-evaluation
#20
Po-Hsiang Chiu, George Hripcsak
In data-driven phenotyping, a core computational task is to identify medical concepts and their variations from sources of electronic health records (EHR) to stratify phenotypic cohorts. A conventional analytic framework for phenotyping largely uses a manual knowledge engineering approach or a supervised learning approach where clinical cases are represented by variables encompassing diagnoses, medicinal treatments and laboratory tests, among others. In such a framework, tasks associated with feature engineering and data annotation remain a tedious and expensive exercise, resulting in poor scalability...
April 11, 2017: Journal of Biomedical Informatics
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