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https://www.readbyqxmd.com/read/28210226/combination-of-collagen-based-scaffold-and-bioactive-factors-induces-adipose-derived-mesenchymal-stem-cells-chondrogenic-differentiation-in-vitro
#1
Giovanna Calabrese, Stefano Forte, Rosario Gulino, Francesco Cefalì, Elisa Figallo, Lucia Salvatorelli, Eugenia T Maniscalchi, Giuseppe Angelico, Rosalba Parenti, Massimo Gulisano, Lorenzo Memeo, Raffaella Giuffrida
Recently, multipotent mesenchymal stem cells (MSCs) have attracted much attention in the field of regenerative medicine due to their ability to give rise to different cell types, including chondrocytes. Damaged articular cartilage repair is one of the most challenging issues for regenerative medicine, due to the intrinsic limited capability of cartilage to heal because of its avascular nature. While surgical approaches like chondral autografts and allografts provide symptoms and function improvement only for a short period, MSC based stimulation therapies, like microfracture surgery or autologous matrix-induced chondrogenesis demonstrate to be more effective...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#2
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28208801/atomic-force-microscopy-a-powerful-tool-to-address-scaffold-design-in-tissue-engineering
#3
Marica Marrese, Vincenzo Guarino, Luigi Ambrosio
Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response...
February 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28202228/cross-institutional-knowledge-based-planning-kbp-implementation-and-its-performance-comparison-to-auto-planning-engine-ape
#4
Binbin Wu, Martijn Kusters, Martina Kunze-Busch, Tim Dijkema, Todd McNutt, Giuseppe Sanguineti, Karl Bzdusek, Anatoly Dritschilo, Dalong Pang
BACKGROUND AND PURPOSE: To investigate (1) whether a plan library established at one institution can be applied for another institution's knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE). MATERIAL AND METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV(68) and 50.3Gy to PTV(50.3)) with clinically-delivered and comparative APE plans. The Johns Hopkins University (JHU) contributed a three-dose-level plan library consisting of 179 clinically-delivered plans...
February 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28197569/microfabricated-tools-for-quantitative-plant-biology
#5
Meltem Elitaş, Meral Yüce, Hikmet Budak
The development of microfabricated devices that will provide high-throughput quantitative data and high resolution in a fast, repeatable and reproducible manner is essential for plant biology research. Plants have been intensely explored since the beginning of humanity, especially for medical needs. However, plant biology research is still laborious, lacking the latest technological advancements in the laboratory practices. Microfabricated tools can provide a significant contribution to plant biology research since they require small volumes of samples and reagents with minimal cost and labor...
February 15, 2017: Analyst
https://www.readbyqxmd.com/read/28196661/pediatric-medical-device-development-by-surgeons-via-capstone-engineering-design-programs
#6
Bryan S Sack, Rodolfo A Elizondo, Gene O Huang, Nicolette Janzen, Jimmy Espinoza, Magdalena Sanz-Cortes, Jennifer E Dietrich, Julie Hakim, Eric Richardson, Maria Oden, John Hanks, Balakrishna Haridas, James F Hury, Chester J Koh
BACKGROUND: There is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's hospitals and academia that can support pediatric device development. We describe our experience with pediatric device design utilizing collaborations between a children's hospital and two engineering schools. METHODS: Utilizing the academic year as a timeline, unmet pediatric device needs were identified by surgical faculty and matched with an engineering mentor and a team of students within the Capstone Engineering Design programs at two universities...
February 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28192272/baastrup-s-disease-a-comprehensive-review-of-the-extant-literature
#7
REVIEW
Fernando Alonso, Ellie Bryant, Joe Iwanaga, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
Reports of Baastrup's disease has been underrepresented in the medical literature. Therefore, the current comprehensive review was performed by searching standard search engines using the terms "Baastrup's", "disease", "lumbar" "interspinous bursitis", and "kissing spine disease." Baastrup's disease appears to be more common than once believed. Baastrup's disease is associated with other degenerative disease processes of the spine that could potentially lead a physician to perform unnecessary surgery. Appreciation of this disease and identification on imaging can improve diagnosis and appropriate treatment of associated back pain...
February 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28190507/best-practices-in-early-phase-medical-device-development-engineering-prototyping-and-the-beginnings-of-a-quality-management-system
#8
Kristy Fearis, Aidan Petrie
Kristy Fearis is the founder and president of KPConsulting. She has held various positions in the medical device and research industry. She has led programs for medical industry leaders Medtronic, Edward Lifesciences, and Kimberly-Clark Healthcare to develop and commercialize Class II and III devices. Although a true quality management systems specialist at heart, Kristy has a passion for effectively and efficiently applying quality systems principles to early stage development to maximize benefit while minimizing impact on resources and time to market...
March 2017: Surgery
https://www.readbyqxmd.com/read/28188997/china-s-landscape-in-regenerative-medicine
#9
REVIEW
Xin Tang, Hua Qin, Xiaosong Gu, Xiaobing Fu
Regenerative medicine is a burgeoning interdisciplinary research field that can impact healthcare by offering new therapeutic strategies to replace or regenerate human cells, tissues, or organs with the ultimate goal of restoring or establishing normal human functions. The past decade has seen significant progress of regenerative medicine in China, the world's most populous developing country. With government backing, the progress in regenerative medicine is driven by increasing medical demands of people, accompanied by the economic growth, population aging, and lifestyle change in China...
February 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28188201/a-day-of-immersive-physiology-experiments-increases-knowledge-and-excitement-towards-physiology-and-scientific-careers-in-native-american-students
#10
Bryan K Becker, Alicia M Schiller, Irving H Zucker, Eric A Eager, Liliana P Bronner, Maurice Godfrey
Underserved minority groups are disproportionately absent from the pursuit of careers in science, technology, engineering, and mathematics (STEM) fields. One such underserved population, Native Americans, are particularly underrepresented in STEM fields. Although recent advocacy and outreach designed toward increasing minority involvement in health care-related occupations have been mostly successful, little is known about the efficacy of outreach programs in increasing minority enthusiasm toward careers in traditional scientific professions...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28186058/usability-validation-of-medical-devices-issues-in-identifying-potential-use-errors
#11
Jessica Schiro, Sylvia Pelayo, Thomas Weinhold, Marzia Del Zotto, Romaric Marcilly
In order to prevent use errors with their medical devices, manufacturers have to integrate a safety-oriented usability engineering process in their product development lifecycle. A critical step of this process is the identification of potential use-errors. Standards and guidelines recommend to triangulate several sources of information e.g. scientific literature, incident reports, manufacturer's files and user's feedbacks. This paper presents lessons learned from applying these recommendations during an international project...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28183638/electrospinning-of-silk-fibroin-from-all-aqueous-solution-at-low-concentration
#12
Yuki Kishimoto, Hideaki Morikawa, Shigeru Yamanaka, Yasushi Tamada
Non-woven mats of Bombyx mori silk fibroin were fabricated using electrospinning with an all aqueous solution at <10wt% without any co-existing water soluble polymer such as PEO. The fibroin aqueous solution electrospinnability was affected by the fibroin molecular weight and the spinning solution pH. Hot-water treatment without any alkaline reagent or soap produced higher molecular weight fibroin than the typical degumming process did. The higher molecular weight fibroin provided good electrospinnability...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183602/a-biological-method-for-in-situ-synthesis-of-hydroxyapatite-coated-magnetite-nanoparticles-using-enterobacter-aerogenes-characterization-and-acute-toxicity-assessments
#13
Elham Ahmadzadeh, Farid Talebnia Rowshan, Morteza Hosseini
Hydroxyapatite (HA)-coated magnetite nanoparticles (MNPs) are being widely investigated for various applications in medical engineering and wastewater treatment. In this work, the MNPs were thoroughly coated by bacterial synthesized HA nanoparticles during biomineralization process using Enterobacter aerogenes. The resulting bacterial-induced precipitate was then calcined at 600°C and investigated with respect to structural characteristics, particle size and magnetic strength by XRD, FT-IR, SEM, EDS, TEM and VSM analyses...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183437/cardiac-3d-printing-and-its-future-directions
#14
REVIEW
Marija Vukicevic, Bobak Mosadegh, James K Min, Stephen H Little
Three-dimensional (3D) printing is at the crossroads of printer and materials engineering, noninvasive diagnostic imaging, computer-aided design, and structural heart intervention. Cardiovascular applications of this technology development include the use of patient-specific 3D models for medical teaching, exploration of valve and vessel function, surgical and catheter-based procedural planning, and early work in designing and refining the latest innovations in percutaneous structural devices. In this review, we discuss the methods and materials being used for 3D printing today...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28179545/a-sterilizable-biocompatible-tropoelastin-surface-coating-immobilized-by-energetic-ion-activation
#15
Giselle C Yeo, Alexey Kondyurin, Elena Kosobrodova, Anthony S Weiss, Marcela M M Bilek
Biomimetic materials which integrate with surrounding tissues and regulate new tissue formation are attractive for tissue engineering and regenerative medicine. Plasma immersion ion-implanted (PIII) polyethersulfone (PES) provides an excellent platform for the irreversible immobilization of bioactive proteins and peptides. PIII treatment significantly improves PES wettability and results in the formation of acidic groups on the PES surface, with the highest concentration observed at 40-80 s of PIII treatment...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28178606/breast-reconstruction-post-mastectomy-let-s-google-it-accessibility-readability-and-quality-of-online-information
#16
Noel P Lynch, Bronagh Lang, Sophia Angelov, Sarah A McGarrigle, Terence J Boyle, Dhafir Al-Azawi, Elizabeth M Connolly
INTRODUCTION: This study evaluated the readability, accessibility and quality of information pertaining to breast reconstruction post mastectomy on the Internet in the English language. METHODS: Using the Google(©) search engine the keywords "Breast reconstruction post mastectomy" were searched for. We analyzed the top 75 sites. The Flesch Reading Ease Score and Gunning Fog Index were calculated to assess readability. Web site quality was assessed objectively using the University of Michigan Consumer Health Web site Evaluation Checklist...
February 5, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28174390/-surgical-regeneration-therapy-using-myoblast-sheets-for-severe-heart-failure
#17
Yoshiki Sawa
Heart failure is a life-threatening disorder worldwide, and the current end-stage therapies for severe heart failure are replacement therapies such as ventricular-assist devices and heart transplantation. Although these therapies have been reported to be useful, there are many issues in terms of the durability, complications, limited donors, adverse effect of continuous administration of immunosuppressive agents, and high costs involved. Recently, regenerative therapy based on genetic, cellular, or tissue engineering techniques has gained attention as a new therapy to overcome the challenges encountered in transplantation medicine...
January 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28169129/adapting-a-psychosocial-intervention-for-smartphone-delivery-to-middle-aged-and-older-adults-with-serious-mental-illness
#18
Karen L Whiteman, Matthew C Lohman, Lydia E Gill, Martha L Bruce, Stephen J Bartels
OBJECTIVE: To describe the process of adapting an integrated medical and psychiatric self-management intervention to a smartphone application for middle-aged and older adults with serious mental illness using an adaptive systems engineering framework and user-centered design. METHODS: First, we determined the technical abilities and needs of middle-aged and older adults with serious mental illnesses using smartphones. Then, we developed smartphone content through principles of user-centered design and modified an existing smartphone platform...
January 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28164084/comparison-of-phenylephrine-and-ephedrine-in-treatment-of-spinal-induced-hypotension-in-high-risk-pregnancies-a-narrative-review
#19
REVIEW
Sasima Dusitkasem, Blair H Herndon, Monsicha Somjit, David L Stahl, Emily Bitticker, John C Coffman
PURPOSE: To compare maternal and fetal effects of intravenous phenylephrine and ephedrine administration during spinal anesthesia for cesarean delivery in high-risk pregnancies. SOURCE: An extensive literature search was conducted using the US National Library of Medicine, MEDLINE search engine, Cochrane review, and Google Scholar using search terms "ephedrine and phenylephrine," "preterm and term and spinal hypotension," "preeclampsia and healthy parturients," or "multiple and singleton gestation and vasopressor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28163228/a-novel-in-situ-silver-hyaluronan-bio-nanocomposite-fabrics-for-wound-and-chronic-ulcer-dressing-in-vitro-and-in-vivo-evaluations
#20
A M Abdel-Mohsen, J Jancar, R M Abdel-Rahman, L Vojtek, P Hyršl, M Dušková, H Nejezchlebová
In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers/fabrics for the first time. Different concentrations of silver nitrate (1, 2mg/100ml) were added at ambient temperature to sodium hyaluronate solution (40mg/ml), then the pH was increased to 8 by adding sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers/nonwoven fabrics by wet-dry-spinning technique (WDST). UV/vis spectroscopy, SEM, TEM, DLS, XPS, XRD and TGA were employed to characterize the structure and composition of the nanocomposite, surface morphology of fiber/fabrics, particle size of Ag-NPs, chemical interactions of Ag(0) and HA functional groups, crystallinity and thermal stability of the wound dressing, respectively...
February 3, 2017: International Journal of Pharmaceutics
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