Sachi Sant, Etienne Gouraud, Camille Boisson, Elie Nader, Mounika Goparaju, Giovanna Cannas, Alexandra Gauthier, Philippe Joly, Céline Renoux, Salima Merazga, Christophe Hautier, Philippe Connes, Marianne Fenech
Patients with sickle cell disease (SCD) have poorly deformable red blood cells (RBC) that may impede blood flow into microcirculation. Very few studies have been able to directly visualize microcirculation in humans with SCD. Sublingual video microscopy was performed in eight healthy (HbAA genotype) and four sickle cell individuals (HbSS genotype). Their hematocrit, blood viscosity, red blood cell deformability, and aggregation were individually determined through blood sample collections. Their microcirculation morphology (vessel density and diameter) and microcirculation hemodynamics (local velocity, local viscosity, and local red blood cell deformability) were investigated...
February 11, 2023: International Journal of Molecular Sciences