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Sidestream dark field imaging

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https://www.readbyqxmd.com/read/28338505/effects-of-hypertonic-saline-and-sodium-lactate-on-cortical-cerebral-microcirculation-and-brain-tissue-oxygenation
#1
Vlasta Dostalova, Jitka Schreiberova, Vlasta Dostalova, Jiri Paral, Jaroslav Kraus, Alena Ticha, Vera Radochova, Pavel Dostal
BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of hypertonic saline (HTS) and sodium lactate (HTL) on cerebral cortical microcirculation and brain tissue oxygenation in a rabbit craniotomy model. METHODS: Rabbits (weight, 1.5 to 2.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3...
March 23, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28298202/evaluation-of-sublingual-microcirculation-in-a-paediatric-intensive-care-unit-prospective-observational-study-about-its-feasibility-and-utility
#2
Rafael González, Jorge López, Javier Urbano, María José Solana, Sarah Nicole Fernández, María José Santiago, Jesús López-Herce
BACKGROUND: Evaluation of the microcirculation in critically ill patients is usually done by means of indirect parameters. The aim of our study was to evaluate the functional state of the microcirculation by direct visualization of sublingual microcirculation using Sidestream Dark Field Imaging, to determine the correlation between these findings and other parameters that are commonly used in the clinical practice and to assess the applicability of the systematic use of this technique in critically ill children...
March 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28219329/ultrafiltration-rate-is-an-important-determinant-of-microcirculatory-alterations-during-chronic-renal-replacement-therapy
#3
Gerke Veenstra, Andrius Pranskunas, Inga Skarupskiene, Vidas Pilvinis, Marc H Hemmelder, Can Ince, E Christiaan Boerma
BACKGROUND: Hemodialysis (HD) with ultrafiltration (UF) in chronic renal replacement therapy is associated with hemodynamic instability, morbidity and mortality. Sublingual Sidestream Dark Field (SDF) imaging during HD revealed reductions in microcirculatory blood flow (MFI). This study aims to determine underlying mechanisms. METHODS: The study was performed in the Medical Centre Leeuwarden and the Lithuanian University of Health Sciences. Patients underwent 4-h HD session with linear UF...
February 20, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28073175/postreperfusion-microcirculatory-derangements-after-liver-transplantation-relationship-to-hemodynamics-serum-mediators-and-outcome
#4
Carlo Pulitano, David Joseph, Charbel Sandroussi, Deborah Verran, Phong Ho, Ashe Debiasio, Adriano Luongo, Geoffrey W McCaughan, Nicholas A Shackel, Michael Crawford
Despite the growing data supporting the role of microcirculation in regulating liver function, little of this knowledge has been translated into clinical practice. The aim of this study is to quantify hepatic microcirculation in vivo using sidestream dark field (SDF) imaging and correlate these findings with hepatic blood flow, hemodynamic parameters, and soluble mediators. Postreperfusion hepatic microcirculation was assessed using SDF imaging. Hepatic microcirculation measurements included functional sinusoidal density (cm/cm(2) ), sinusoidal diameter (μm), red blood cell velocity (μm/second), volumetric blood flow (pl/second), and flow heterogeneity (FH) index...
April 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28057660/protocol-for-intraoperative-assessment-of-the-human-cerebrovascular-glycocalyx
#5
R H L Haeren, H Vink, J Staals, M A M J van Zandvoort, J Dings, J J van Overbeeke, G Hoogland, K Rijkers, O E M G Schijns
INTRODUCTION: Adequate functioning of the blood-brain barrier (BBB) is important for brain homoeostasis and normal neuronal function. Disruption of the BBB has been described in several neurological diseases. Recent reports suggest that an increased permeability of the BBB also contributes to increased seizure susceptibility in patients with epilepsy. The endothelial glycocalyx is coating the luminal side of the endothelium and can be considered as the first barrier of the BBB. We hypothesise that an altered glycocalyx thickness plays a role in the aetiology of temporal lobe epilepsy (TLE), the most common type of epilepsy...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/27984315/effect-of-pulsatility-on-microcirculation-in-patients-treated-with-extracorporeal-cardiopulmonary-resuscitation-a-pilot-study
#6
Petra Krupičková, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Ondřej Šmíd, Aleš Král, Hana Skalická, Aleš Linhart, Jan Bělohlávek
The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated, therefore we designed an observational study comparing sublingual microcirculation in refractory cardiac arrest patients with spontaneously pulsatile or low/non-pulsatile blood flow following treatment with ECPR. Microcirculation was assessed with Sidestream Dark Field technology in 12 cardiac arrest patients treated with ECPR and 12 healthy controls. Microcirculatory images were analyzed offline in a blinded fashion and consensual parameters were determined for the vessels ≤ 20 μm...
December 13, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27931654/the-response-of-the-microcirculation-to-mechanical-support-of-the-heart-in-critical-illness
#7
REVIEW
Sakir Akin, Atila Kara, Corstiaan A den Uil, Can Ince
Critical illness associated with cardiac pump failure results in reduced tissue perfusion in all organs and occurs in various conditions such as sepsis, cardiogenic shock, and heart failure. Mechanical circulatory support (MCS) devices can be used to maintain organ perfusion in patients with cardiogenic shock and decompensated chronic heart failure. However, correction of global hemodynamic parameters by MCS does not always cause a parallel improvement in microcirculatory perfusion and oxygenation of the organ systems, a condition referred to as a loss of hemodynamic coherence between macro- and microcirculation (MC)...
December 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27698325/use-of-an-image-acquisition-stabilizer-improves-sidestream-dark-field-imaging-of-the-serosa-during-open-gastrointestinal-surgery
#8
Anthonius F J de Bruin, Arthur Tavy, Koene van der Sloot, Anke Smits, Bert Van Ramshorst, Christiaan E Boerma, Peter Kars, Peter G Noordzij, Djamila Boerma, Mat van Iterson
AIM: To investigate whether an image acquisition stabilizer (IAS) mounted on the sidestream dark field camera (SDF) during gastrointestinal surgery improves image stability and acquisition. METHODS: Serosal SDF imaging was compared with SDF imaging combined with an IAS (SDF + IAS) during gastrointestinal surgery. Stability was assessed as the image drift in pixels and the time to obtain stable images. The success rate was determined as the percentage of analyzable images after recording...
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27635767/effect-of-rbc-transfusion-on-sublingual-microcirculation-in-hemorrhagic-shock-patients-a-pilot-study
#9
Sebastien Tanaka, Etienne Escudier, Sophie Hamada, Anatole Harrois, Pierre Etienne Leblanc, Eric Vicaut, Jacques Duranteau
OBJECTIVES: The effects of RBC transfusion on microvascular perfusion are not well documented. We investigated the effect of RBC transfusion on sublingual microcirculation in hemorrhagic shock patients. DESIGN: Prospective, preliminary observational study. SETTINGS: A 28-bed, surgical ICU in a university hospital. PATIENTS: Fifteen hemorrhagic shock patients requiring RBC transfusion. INTERVENTION: Transfusion of one unit of RBCs...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27590460/dexmedetomidine-versus-propofol-sedation-improves-sublingual-microcirculation-after-cardiac-surgery-a-randomized-controlled-trial
#10
Xu Liu, Kai Zhang, Wei Wang, Guohao Xie, Baoli Cheng, Yan Wang, Yaoqin Hu, Xiangming Fang
OBJECTIVES: To compare the effects of dexmedetomidine and propofol on sublingual microcirculation in patients after cardiac surgery. DESIGN: A prospective, randomized, single-blind study. SETTING: University hospital. PARTICIPANTS: Adult patients undergoing elective valve surgery with cardiopulmonary bypass. INTERVENTIONS: On arrival in the intensive care unit (ICU), patients were assigned randomly to receive either dexmedetomidine (0...
December 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27539312/impact-of-microcirculatory-video-quality-on-the-evaluation-of-sublingual-microcirculation-in-critically-ill-patients
#11
Elisa Damiani, Can Ince, Claudia Scorcella, Roberta Domizi, Andrea Carsetti, Nicoletta Mininno, Silvia Pierantozzi, Erica Adrario, Rocco Romano, Paolo Pelaia, Abele Donati
We aimed to assess the impact of image quality on microcirculatory evaluation with sidestream dark-field (SDF) videomicroscopy in critically ill patients and explore factors associated with low video quality. This was a retrospective analysis of a single-centre prospective observational study. Videos of the sublingual microcirculation were recorded using SDF videomicroscopy in 100 adult patients within 12 h from admittance to the intensive care unit and every 24 h until discharge/death. Parameters of vessel density and perfusion were calculated offline for small vessels...
August 18, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27480483/accessing-the-biocompatibility-of-layered-double-hydroxide-by-intramuscular-implantation-histological-and-microcirculation-evaluation
#12
Vanessa Roberta Rodrigues Cunha, Rodrigo Barbosa de Souza, Ana Maria Cristina Rebello Pinto da Fonseca Martins, Ivan Hong Jun Koh, Vera Regina Leopoldo Constantino
Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule nearby the LDH was noticed for both materials as well any sign of inflammatory reactions...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27401581/conjunctival-microcirculatory-blood-flow-is-altered-but-not-abolished-in-brain-dead-patients-a-prospective-observational-study
#13
Tomas Tamosuitis, Andrius Pranskunas, Neringa Balciuniene, Vidas Pilvinis, E Christiaan Boerma
BACKGROUND: The conjunctival microcirculation has potential as a window to cerebral perfusion due to related blood supply, close anatomical proximity and easy accessibility for microcirculatory imaging technique, such as sidestream dark field (SDF) imaging. Our study aims to evaluate conjunctival and sublingual microcirculation in brain dead patients and to compare it with healthy volunteers in two diametrically opposed conditions: full stop versus normal arterial blood supply to the brain...
July 11, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27277706/microcirculatory-blood-flow-during-cardiac-arrest-and-cardiopulmonary-resuscitation-does-not-correlate-with-global-hemodynamics-an-experimental-study
#14
Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart, Jan Bělohlávek
BACKGROUND: Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection to outcome of these patients. However, only few studies evaluated microcirculation directly during cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). The aim of our experimental study in a porcine model was to describe sublingual microcirculatory changes during CA and CPR using recent videomicroscopic technology and provide a comparison to parameters of global hemodynamics...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27230099/association-of-microvascular-function-and-endothelial-biomarkers-with-clinical-outcome-in-dengue-an-observational-study
#15
Sophie Yacoub, Phung Khanh Lam, Le Hoang Mai Vu, Thi Lien Le, Ngo Thanh Ha, Tran Thi Toan, Nguyen Thu Van, Nguyen Than Ha Quyen, Huynh Thi Le Duyen, Nguyen Van Kinh, Annette Fox, Juthathip Mongkolspaya, Marcel Wolbers, Cameron Paul Simmons, Gavin Robert Screaton, Heiman Wertheim, Bridget Wills
BACKGROUND: The hallmark of severe dengue is increased microvascular permeability, but alterations in the microcirculation and their evolution over the course of dengue are unknown. METHODS: We conducted a prospective observational study to evaluate the sublingual microcirculation using side-stream dark-field imaging in patients presenting early (<72 hours after fever onset) and patients hospitalized with warning signs or severe dengue in Vietnam. Clinical findings, microvascular function, global hemodynamics assessed with echocardiography, and serological markers of endothelial activation were determined at 4 time points...
September 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27142381/assessment-and-imaging-of-the-cerebrovascular-glycocalyx
#16
Roel Hubert Louis Haeren, Steffi Elisabeth Maria van de Ven, Marcus Anna Maria Jacobus van Zandvoort, Hans Vink, Jacobus Johannes van Overbeeke, Govert Hoogland, Kim Rijkers
The glycocalyx is a gel-like layer lining the luminal surface of the endothelium. The glycocalyx exerts an important barrier role because it prevents exposure of plasma components to the endothelial surface. Disruption of the glycocalyx by local inflammation or ischemia results in decreased glycocalyx thickness which is associated with a number of vascular diseases. The cerebrovascular glycocalyx has sparsely been studied, but is of great interest because of its potential role in cerebrovascular disease. In this review, we describe all existing techniques to visualize the glycocalyx and designate techniques that may be suitable for studying the cerebrovascular glycocalyx...
2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27126250/quantitative-blood-flow-velocity-imaging-using-laser-speckle-flowmetry
#17
Annemarie Nadort, Koen Kalkman, Ton G van Leeuwen, Dirk J Faber
Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on the influence of the optical properties of scatterers on α in vitro and in vivo. We found a good agreement to theoretical predictions within certain limits for scatterer size and multiple scattering...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27123542/impact-of-mode-of-delivery-on-skin-microcirculation-in-term-healthy-newborns-within-the-first-day-of-life
#18
Ferit Kulali, Ebru Ergenekon, Selma Aktas, Ebru Kazanci, Sezin Unal, İbrahim Hirfanoğlu, Esra Önal, Canan Türkyilmaz, Esin Koç, Yildiz Atalay
BACKGROUND: Microcirculation is an important component of hemodynamic physiology. It can be assessed simply by clinical scores or by a variety of techniques including sidestream dark field (SDF) imaging and peripheral perfusion index (PI) measurements. Mode of delivery may have affects on microcirculation during transitional period. The aim of this study was to compare skin microcirculation in newborns born via vaginal delivery (VD) or cesarian section (C/S). METHODS: Term healthy newborns not requiring NICU admission were included...
March 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27111533/effects-of-dexmedetomidine-on-intestinal-microcirculation-and-intestinal-epithelial-barrier-in-endotoxemic-rats
#19
Yu-Chang Yeh, Chun-Yu Wu, Ya-Jung Cheng, Chih-Min Liu, Jong-Kai Hsiao, Wing-Sum Chan, Zong-Gin Wu, Linda Chia-Hui Yu, Wei-Zen Sun
BACKGROUND: Dexmedetomidine reduces cytokine production in septic patients and reduces inflammation and mortality in experimental models of endotoxemia and sepsis. This study investigated whether dexmedetomidine attenuates endothelial dysfunction, intestinal microcirculatory dysfunction, and intestinal epithelial barrier disruption in endotoxemic rats. METHODS: Ninety-two male Wistar rats were randomly assigned to the following four groups: (1) Sham; (2) lipopolysaccharide, received IV lipopolysaccharide 15 and 10 mg/kg at 0 and 120 min; (3) dexmedetomidine, received IV dexmedetomidine for 240 min; and (4) lipopolysaccharide + dexmedetomidine, received both lipopolysaccharide and dexmedetomidine...
August 2016: Anesthesiology
https://www.readbyqxmd.com/read/26914119/renal-circulation-and-microcirculation-during-intra-abdominal-hypertension-in-a-porcine-model
#20
F Sui, Y Zheng, W-X Li, J-L Zhou
OBJECTIVE: The purpose of the study is to further investigate the effects of increased intra-abdominal pressure (IAP) on renal hemodynamics and renal perfusion, and to evaluate the renal cortical and sublingual microcirculation by sidestream dark field (SDF) imaging, both with a porcine model. MATERIALS AND METHODS: IAP was increased stepwise to 10, 15, 20, 25 mmHg, during which hemodynamic parameters, urinary output, renal contrast-enhanced ultrasound (CEUS), sublingual and renal SDF videos were all recorded from 12 pigs...
2016: European Review for Medical and Pharmacological Sciences
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