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https://www.readbyqxmd.com/read/30242966/modelling-pharmaceutical-emissions-and-their-toxicity-related-impacts-in-life-cycle-assessment-lca-a-review
#1
REVIEW
Yasmine Emara, Annekatrin Lehmann, Marc-William Siegert, Matthias Finkbeiner
Over the last few decades, worldwide detection of active pharmaceutical ingredients (APIs) in aquatic environments and the associated toxicological effects on wildlife and human health have become a matter of public and scientific debate. While life cycle assessment (LCA) and life cycle impact assessment (LCIA) models are increasingly used to assess the potential eco- and human-toxicological impacts of chemical emissions, few studies have looked into the issue of modelling pharmaceutical emissions specifically and their toxicity-related effects in an LCA-context...
September 22, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/30242936/metabolomics-in-the-clinic-a-review-of-the-shared-and-unique-features-of-untargeted-metabolomics-for-clinical-research-and-clinical-testing
#2
Adam D Kennedy, Bryan M Wittmann, Anne M Evans, Luke A D Miller, Douglas R Toal, Shaun Lonergan, Sarah H Elsea, Kirk L Pappan
Metabolomics is the untargeted measurement of the metabolome, which is comprised of the complement of small molecules detected in a biological sample. As such, metabolomic analysis produces a global biochemical phenotype. It is a technology that has been utilized in the research setting for over a decade. The metabolome is directly linked to and is influenced by genetics, epigenetics, environmental factors and the microbiome - all of which affect health. Metabolomics can be applied to human clinical diagnostics and to other fields such as veterinary medicine, nutrition, exercise, physiology, agriculture/plant biochemistry, and toxicology...
September 22, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/30242807/prediction-of-breast-cancer-metastasis-risk-using-circulating-tumor-markers-a-follow-up-study
#3
Sibel Cetintas, Gulcin Tezcan, Berrin Tunca, Unal Egeli, Mustafa Sehsuvar Gokgoz, Gulsah Cecener
Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTM) cytokeratin (CK)19, CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis and recurrence in BC, here we report 7-year follow-up results of 77 patients...
September 17, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30242796/the-influence-of-culture-on-attitudes-towards-humanoid-and-animal-like-robots-an-integrative-review
#4
Irena Papadopoulos, Christina Koulouglioti
PURPOSE: The aim of the present review is to explore the influence of culture on attitudes towards humanoid and animal-like robots. DESIGN: An integrative review of current evidence. METHODS: Medline, CINAHL, PsycInfo, PubMed, and Google Scholar were searched from 2000 to 2017. A total of 22 articles met the inclusion criteria and were retrieved and analyzed. FINDINGS: Culture influences attitudes and preferences towards robots, but due to the limitations of the reviewed studies, concrete conclusions cannot be made...
September 21, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/30242766/isolation-of-human-skin-lymphatic-endothelial-cells-and-3d-reconstruction-of-the-lymphatic-vasculature-in-vitro
#5
Anita Rogic, Francois Auger, Mihaela Skobe
Studies of lymphangiogenesis and lymphatic endothelial biology in vitro require pure cultures of lymphatic endothelial cells and 3D vascular constructs, which closely resemble native human lymphatic vasculature. We describe a method for the isolation of human dermal microvascular lymphatic endothelial cells and generation of a 3D lymphatic capillary network. The lymphatic vascular construct is generated by coculturing primary lymphatic endothelial cells and fibroblasts in their native matrix, without the use of synthetic scaffolds or exogenous factors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30242764/evaluation-and-characterization-of-endothelial-cell-invasion-and-sprouting-behavior
#6
Jocelynda Salvador, George E Davis
Here, we describe highly reproducible methods to investigate human EC invasion and sprouting behavior in 3D collagen matrices. Two assay models are presented whereby ECs are induced to sprout from a monolayer surface or from aggregated ECs suspended within a collagen gel matrix. In each case, the assays are performed using serum-free defined media containing a combination of five growth factors (Factors): FGF-2, SCF, IL-3, SDF-1α, and insulin. In both models, marked EC sprouting occurs with leading EC tip cells over a 12-24 h period...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30242628/hepatoprotective-effect-of-gastrodin-against-alcohol-induced-liver-injury-in-mice
#7
Xin-Xin Li, Zhi-Hui Jiang, Bo Zhou, Chen Chen, Xiao-Ying Zhang
Alcoholic liver disease (ALD) is a common and serious threat to human health worldwide. In this study, the hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice was examined. Mice with alcohol-induced hepatotoxicity were treated intragastrically with gastrodin (50, 80, or 100 mg/kg). The mice treated with gastrodin experienced better outcomes than those who received only one dose of alcohol (50%, 10 mL/kg b.w.). Gastrodin treatment reduced the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), decreased hepatic malondialdehyde (MDA) content, and increased hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities in a dose-dependent manner...
September 21, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30242622/chemical-shift-assignment-of-the-viral-protein-genome-linked-vpg-from-potato-virus-y
#8
Luciana Coutinho de Oliveira, Laurent Volpon, Michael J Osborne, Katherine L B Borden
The dysregulation of translation contributes to many pathogenic conditions in humans. Discovering new translational mechanisms is important to understanding the diversity of this process and its potential mechanisms. Such mechanisms can be initially observed in viruses. With this in mind, we studied the viral protein genome-linked VPg factor from the largest genus of plant viruses. Studies in plants show that VPg binds to the eukaryotic translation initiation factor eIF4E for translation of viral RNAs. VPg contains no known eIF4E binding motifs and no sequence homology to any known proteins...
September 21, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/30242542/mir-410-3p-suppresses-cytokine-release-from-fibroblast-like-synoviocytes-by-regulating-nf-%C3%AE%C2%BAb-signaling-in-rheumatoid-arthritis
#9
YueJiao Wang, NeiLi Xu, Shuai Zhao, Ting Jiao, WenYi Fu, LiLi Yang, Ning Zhang
miR-410-3p acts as an oncogene or a tumor suppressor in some malignancies. However, its role in rheumatoid arthritis (RA) is unknown. The study was conducted to investigate the effect of miR-410-3p on the pathogenesis of RA. Real-time RT-PCR was used to determine the mRNA levels of miR-410-3p in synovial tissues and fibroblast-like synoviocytes (FLSs). An ELISA was performed to examine the production levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and matrix metalloproteinase (MMP)-9. Western blotting was conducted to determine the protein levels of IκB-α, p-IκBα, p65, and p-p65...
September 21, 2018: Inflammation
https://www.readbyqxmd.com/read/30242290/humanin-prevents-age-related-cognitive-decline-in-mice-and-is-associated-with-improved-cognitive-age-in-humans
#10
Kelvin Yen, Junxiang Wan, Hemal H Mehta, Brendan Miller, Amy Christensen, Morgan E Levine, Matthew P Salomon, Sebastian Brandhorst, Jialin Xiao, Su-Jeong Kim, Gerardo Navarrete, Daniel Campo, G Jean Harry, Valter Longo, Christian J Pike, Wendy J Mack, Howard N Hodis, Eileen M Crimmins, Pinchas Cohen
Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuroprotective effects in vitro in human cell culture models and is sufficient to improve cognition in vivo in aged mice...
September 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30242166/essential-nucleoid-associated-protein-mihf-rv1388-controls-virulence-and-housekeeping-genes-in-mycobacterium-tuberculosis
#11
Nina T Odermatt, Claudia Sala, Andrej Benjak, Stewart T Cole
Tight control of gene expression is crucial for Mycobacterium tuberculosis to adapt to the changing environments encountered when infecting or exiting human cells. While three nucleoid associated proteins (NAPs) EspR, HupB and Lsr2 have been investigated, the role of a fourth, the mycobacterial integration host factor (mIHF), remains elusive. Here, we report a multidisciplinary functional analysis that exploits a conditional mIHF mutant. Gene silencing was bactericidal and resulted in elongated cells devoid of septa, with only one nucleoid...
September 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30242155/structures-of-insect-imp-l2-suggest-an-alternative-strategy-for-regulating-the-bioavailability-of-insulin-like-hormones
#12
Nikolaj Kulahin Roed, Cristina M Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R Ganderton, Johan P Turkenburg, Pierre De Meyts, Andrzej M Brzozowski
The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood in complexes with IGF-binding proteins (IGFBP1-6). Insect insulin-like polypeptide binding proteins (IBPs) have been considered as IGFBP-like structural and functional homologues. Here, we report structures of the Drosophila IBP Imp-L2 in its free form and bound to Drosophila insulin-like peptide 5 and human IGF-1...
September 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/30242135/hypoxia-inducible-factor-1-dependent-expression-of-adenosine-receptor-2b-promotes-breast-cancer-stem-cell-enrichment
#13
Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, Gregg L Semenza
Breast cancer stem cells (BCSCs), which are characterized by a capacity for unlimited self-renewal and for generation of the bulk cancer cell population, play a critical role in cancer relapse and metastasis. Hypoxia is a common feature of the cancer microenvironment that stimulates the specification and maintenance of BCSCs. In this study, we found that hypoxia increased expression of adenosine receptor 2B (A2BR) in human breast cancer cells through the transcriptional activity of hypoxia-inducible factor 1...
September 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30242057/overexpression-of-the-nucleocapsid-protein-of-middle-east-respiratory-syndrome-coronavirus-up-regulates-cxcl10
#14
James Odame Aboagye, Chow Wenn Yew, Oi-Wing Ng, Vanessa M Monteil, Ali Mirazimi, Yee-Joo Tan
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes respiratory diseases in humans and has a high mortality rate. During infection, MERS-CoV regulates several host cellular processes including antiviral response genes. In order to determine if the nucleocapsid protein of MERS-CoV (MERS-N) plays a role in viral-host interactions, a murine monoclonal antibody was generated so as to allow detection of the protein in infected cells as well as in overexpression system. Then, MERS-N was stably overexpressed in A549 cells and a PCR array containing 84 genes was used to screen for genes transcriptionally regulated by it...
September 21, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30242003/identification-and-characterization-of-a-restriction-modification-enzyme-reducing-conjugation-efficiency-in-campylobacter-jejuni-using-a-co-transformation-method
#15
Ximin Zeng, Zuowei Wu, Qijing Zhang, Jun Lin
Conjugation is an important mechanism for horizontal gene transfer in Campylobacter jejuni , the leading cause of human bacterial gastroenteritis in developed countries. However, to date, the factors that significantly influence conjugation efficiency in Campylobacter are still largely unknown. Given that multiple recombinant loci could independently occur within one recipient cell during natural transformation, the genetic materials from high frequency conjugation ( HFC ) C. jejuni strain may be co-transformed with a selection marker into a low frequency conjugation ( LFC ) recipient strain, creating new HFC transformants suitable for identification of conjugation factor using comparative genomics approach...
September 21, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/30241968/deeply-learnt-damped-least-squares-dl-dls-method-for-inverse-kinematics-of-snake-like-robots
#16
Olatunji Mumini Omisore, Shipeng Han, Lingxue Ren, Ahmed Elazab, Li Hui, Talaat Abdelhamid, Nureni Ayofe Azeez, Lei Wang
Recently, snake-like robots are proposed to assist experts during medical procedures on internal organs via natural orifices. Despite their well-spelt advantages, applications in radiosurgery is still hindered by absence of suitable designs required for spatial navigations within clustered and confined parts of human body, and inexistence of precise and fast inverse kinematics (IK) models. In this study, a deeply-learnt damped least squares method is proposed for solving IK of spatial snake-like robot. The robot's model consists of several modules, and each module has a pair of serial-links connected with orthogonal twists...
August 23, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/30241936/the-role-and-regulation-of-tmem2-transmembrane-protein-2-in-hybid-hyaluronan-ha-binding-protein-involved-in-ha-depolymerization-kiaa1199-cemip-mediated-ha-depolymerization-in-human-skin-fibroblasts
#17
Yuta Yoshino, Masakazu Goto, Hideaki Hara, Shintaro Inoue
We have previously reported that HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/KIAA1199/CEMIP) is a specific HA-binding protein that is essential for HA depolymerization in skin and synovial fibroblasts. HA is incorporated into cells in the presence of HYBID and clathrin, degraded in endosomes, and excreted into the extracellular space. However, it is not yet clear whether HYBID itself catalytically cleaves HA. A recent report on transmembrane protein 2 (TMEM2)-a novel cell surface hyaluronidase-prompted us to investigate whether TMEM2 is essential for HYBID-mediated HA depolymerization...
September 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30241825/pickering-emulsions-stabilized-nanocellulosic-based-nanoparticles-for-coumarin-and-curcumin-nanoencapsulations-in-vitro-release-anticancer-and-antimicrobial-activities
#18
Fahanwi Asabuwa Ngwabebhoh, Sevinc Ilkar Erdagi, Ufuk Yildiz
Coumarin and curcumin have a wide spectrum of biological and pharmacological activities including antioxidant, anti-inflammatory, antimicrobial and anticancer but hindered therapeutic applications due to low stability and poor solubility in water. The main objective of the current study was to overcome these drawbacks via improved bioavailability by nanoencapsulated emulsions. Pickering emulsion (PE) via oil-in-water approach were stabilized by aminated nanocellulose (ANC) particles through application of a full factorial optimization design for nanoemulsions containing different composition of oil phase with medium chain triglyceride (MCT) and Tween 80...
December 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30241820/antineoplastic-effect-of-pectic-polysaccharides-from-green-sweet-pepper-capsicum-annuum-on-mammary-tumor-cells-in-vivo-and-in-vitro
#19
Eliana Rezende Adami, Claudia Rita Corso, Natalia Mulinari Turin-Oliveira, Claudia Martins Galindo, Letícia Milani, Maria Caroline Stipp, Georgia Erdmann do Nascimento, Andressa Chequin, Luisa Mota da Silva, Sérgio Faloni de Andrade, Rosangela Locatelli Dittrich, José Ederaldo Queiroz-Telles, Giseli Klassen, Edneia A S Ramos, Lucimara M C Cordeiro, Alexandra Acco
The present study investigated the antineoplastic effects of pectic polysaccharides that were extracted from green sweet pepper (Capsicum annuum [CAP]) in the Ehrlich carcinoma in mice and in human mammary tumor lineages. After the subcutaneous inoculation of 2 × 106 Ehrlich tumor cells, Female Swiss mice received 50, 100, or 150 mg/kg CAP or vehicle orally once daily or methotrexate (2.5 mg/kg, i.p., every 5 days) for 21 days. CAP dose-dependently reduced Ehrlich tumor growth. It also reduced the viability of MCF-7, MDA-MB-231, and MDA-MB-436 human mammary cell lineages...
December 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30241815/conductive-bacterial-cellulose-multiwall-carbon-nanotubes-nanocomposite-aerogel-as-a-potentially-flexible-lightweight-strain-sensor
#20
Hadi Hosseini, Mehrdad Kokabi, Seyyed Mohammad Mousavi
In this work, in-situ biosynthesized bacterial cellulose (BC) /multiwall carbon nanotubes (MWCNTs) nanocomposite hydrogels converted to the conductive nanocomposite aerogels via the supercritical CO2 method. A low percolation threshold value of 0.0041 (volume concentration) predicted for BC/MWCNTs nanocomposite aerogels by the proposed modified model. The piezoresistive behavior of the nanocomposite aerogel at percolation threshold, evaluated in tension mode. The strain sensing outcomes revealed a linear trend during loading until a critical strain, afterward began to decline with further increasing of strain...
December 1, 2018: Carbohydrate Polymers
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