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https://www.readbyqxmd.com/read/29929213/gut-microbiome-in-type-1-diabetes-a-comprehensive-review
#1
REVIEW
Peilin Zheng, Zhixia Li, Zhiguang Zhou
Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome-wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D have been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D-triggering factors, especially environmental factors...
June 21, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29929138/prothrombotic-mechanisms-in-patients-with-congenital-p-cys89tyr-mutation-in-cd59
#2
Adi Tabib, Issam Hindi, Netanel Karbian, Orly Zelig, Batla Falach, Dror Mevorach
BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating neuropathy. Here we investigated hypercoagulability mechanisms characterizing the syndrome...
June 11, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29929047/isolated-hypospadias-the-impact-of-prenatal-exposure-to-pesticides-as-determined-by-meconium-analysis
#3
Elodie Haraux, Pierre Tourneux, Christelle Kouakam, Erwan Stephan-Blanchard, Bernard Boudailliez, Andre Leke, Celine Klein, Karen Chardon
Although endocrine-disrupting chemicals (EDCs, including pesticides) are thought to increase the risk of hypospadias, no compounds have been formally identified in this context. Human studies may now be possible via the assessment of meconium as a marker of chronic prenatal exposure. The objective of the present study was to determine whether or not prenatal exposure to pesticides (as detected in meconium) constitutes a risk factor for isolated hypospadias. In a case-control study performed between 2011 and 2014 in northern France, male newborns with isolated hypospadias (n = 25) were matched at birth with controls (n = 58)...
June 18, 2018: Environment International
https://www.readbyqxmd.com/read/29929037/proteomic-characterization-of-six-taiwanese-snake-venoms-identification-of-species-specific-proteins-and-development-of-a-siscapa-mrm-assay-for-cobra-venom-factors
#4
Chien-Chun Liu, Chih-Chuan Lin, Yung-Chin Hsiao, Po-Jung Wang, Jau-Song Yu
Deinagkistrodon acutus, Trimeresurus stejnegeri, Protobothrops mucrosquamatus, Daboia russelii siamensis, Bungarus multicinctus and Naja atra are the six medically important venomous snake species in Taiwan. In this study, we characterized and compared their venom protein profiles using proteomic approaches. The major snake venom proteins were identified by GeLC-MS/MS and the total venom proteome was characterized by in-solution digestion coupled with LC-MS/MS. A total of 27-52 proteins, categorized into 23 protein families, were identified in each snake's venom...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29928962/oral-recombinant-methioninase-o-rmetase-is-superior-to-injectable-rmetase-and-overcomes-acquired-gemcitabine-resistance-in-pancreatic-cancer
#5
Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Michael Bouvet, Shree Ram Singh, Michiaki Unno, Robert M Hoffman
Recombinant methioninase (rMETase) was administered as an injectable drug to target methionine dependence of cancer. Recently, we observed that rMETase could be administered orally (o-rMETase) in a patient-derived orthotopic xenograft (PDOX) mouse model of melanoma. Here, we determined the efficacy of o-rMETase on a pancreatic cancer PDOX model. Forty pancreatic cancer PDOX mouse models were randomized into four groups of 10 mice each. o-rMETase was significantly more effective than i.p.-rMETase, but combination of both was significantly more effective...
June 18, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29928930/effect-of-estetrol-a-selective-nuclear-estrogen-receptor-modulator-in-mouse-models-of-arterial-and-venous-thrombosis
#6
Marie-Cécile Valéra, Emmanuelle Noirrit-Esclassan, Marion Dupuis, Coralie Fontaine, Françoise Lenfant, Anne Briaux, Cendrine Cabou, Cedric Garcia, Olivier Lairez, Jean-Michel Foidart, Bernard Payrastre, Jean-François Arnal
Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the circulating level of coagulation factors, at variance to oral estradiol or ethinylestradiol. Here, we evaluated the effect of E4 on hemostasis and thrombosis in mouse. Following chronic E4 treatment, mice exhibited a prolonged tail-bleeding time and were protected from arterial and also venous thrombosis in vivo...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928903/biochemical-characterization-of-human-tissue-kallikrein-15-and-examination-of-its-potential-role-in-cancer
#7
Panagiota S Filippou, Annie H Ren, Sudarshan Bala, Michail-Dimitrios Papaioannou, Davor Brinc, Ioannis Prassas, Theano Karakosta, Eleftherios P Diamandis
OBJECTIVE: Human tissue kallikrein 15 (KLK15) is the last cloned member of the KLK-related gene family. Despite being implicated in multiple cancers, its pathophysiological role remains unknown. We aimed to biochemically characterize KLK15 and preliminarily study its role in cancer. DESIGN & METHODS: Recombinant KLK15 protein was produced, purified to homogeneity and quantified by mass spectrometry (parallel reaction monitoring analysis). We profiled the enzymatic activity of KLK15 using fluorogenic peptide substrates, and performed kinetic analysis to discover the cleavage sites...
June 18, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29928895/hdl-apoa-i-induces-the-expression-of-angiopoietin-like-4-angptl4-in-endothelial-cells-via-a-pi3k-akt-foxo1-signaling-pathway
#8
Dimitris Theofilatos, Panagiotis Fotakis, Efi Valanti, Despina Sanoudou, Vassilis Zannis, Dimitris Kardassis
BACKGROUND: High Density Lipoprotein (HDL) and its main protein component, apolipoprotein A-I (apoA-I) have numerous atheroprotective functions on various tissues including the endothelium. Therapies based on reconstituted HDL containing apoA-I (rHDL-apoA-I) have been used successfully in patients with acute coronary syndrome, peripheral vascular disease or diabetes but very little is known about the genomic effects of rHDL-apoA-I and how they could contribute to atheroprotection. OBJECTIVE: The present study aimed to understand the endothelial signaling pathways and the genes that may contribute to rHDL-apoA-I-mediated atheroprotection...
June 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29928880/ube2s-enhances-the-ubiquitination-of-p53-and-exerts-oncogenic-activities-in-hepatocellular-carcinoma
#9
Ying-Hua Pan, Mei Yang, Li-Ping Liu, Dan-Chun Wu, Ming-Yue Li, Shu-Guang Su
Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Increased expression of UBE2S was significantly correlated with higher serum AFP level, higher pathological grade, advanced TNM stage, larger tumor size, vascular invasion and unfavorable patient survivals in two independent cohorts containing a total of 845 patients with HCC...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928672/neonatal-colonic-inflammation-epigenetically-aggravates-epithelial-inflammatory-responses-to-injury-in-adult-life
#10
Xiaoying S Zhong, John H Winston, Xiuju Luo, Kevin T Kline, Syed Z Nayeem, Yingzi Cong, Tor C Savidge, Roderick H Dashwood, Don W Powell, Qingjie Li
Background & Aims: Early life adversity is considered a risk factor for the development of gastrointestinal diseases, including inflammatory bowel disease. We hypothesized that early life colonic inflammation causes susceptibility to aggravated overexpression of interleukin (IL)1β. Methods: We developed a 2-hit rat model in which neonatal inflammation (NI) and adult inflammation (AI) were induced by trinitrobenzene sulfonic acid. Results: Aggravated immune responses were observed in NI + AI rats, including a sustained up-regulation of IL1β and other cytokines...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928633/evaluation-of-electroencephalogram-signals-of-the-professional-pianists-during-iconic-memory-and-working-memory-tests-using-spectral-coherence
#11
Seyedeh Yasamin Boutorabi, Ali Sheikhani
Background: Today, the neuroscience has growth in many aspects, and the effects of different factors on memory obtained many achievements. Several scientific and experimental studies evaluated effects of music on style and behavior of people; in this study, we evaluated memory between two groups of people, the professional pianists and normal people, through processing their electroencephalogram (EEG) signals using the coherence measure. Methods: In this study, EEG signals from 17 subjects during two memory tasks were recorded...
April 2018: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/29928538/developing-a-basic-scale-for-workers-psychological-burden-from-the-perspective-of-occupational-safety-and-health
#12
Kyung Woo Kim, Ho Chan Lim, Jae Hee Park, Sang Gyu Park, Ye Jin Park, Hm Hak Cho
Background: Organizations are pursing complex and diverse aims to generate higher profits. Many workers experience high work intensity such as workload and work pressure in this organizational environment. Especially, psychological burden is a commonly used term in workplace of Republic of Korea. This study focused on defining the psychological burden from the perspective of occupational safety and health and tried to develop a scale for psychological burden. Methods: The 48 preliminary questionnaire items for psychological burden were prepared by a focus group interview with 16 workers through the Copenhagen Psychosocial Questionnaire II and Mindful Awareness Attention Scale...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928530/safety-knowledge-and-changing-behavior-in-agricultural-workers-an-assessment-model-applied-in-central-italy
#13
Massimo Cecchini, Roberto Bedini, Davide Mosetti, Sonia Marino, Serenella Stasi
Background: In recent years, the interest in health and safety in the workplace has increased. Agriculture is one of the human work activities with the highest risk indexes. Studies on risk perception of agricultural workers are often referred to as specific risk factors (especially pesticides), but the risk perception plays an important role in preventing every kind of accident and occupational disease. Methods: The aim of this research is to test a new method for understanding the relation between risk perception among farmers and the main risk factors to which they are exposed...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928497/a-superior-bright-nir-luminescent-nanoparticle-preparation-and-indicating-calcium-signaling-detection-in-cells-and-small-animals
#14
Jian Zhang, Joseph R Lakowicz
Background: Near-field fluorescence (NFF) effects were employed to develop a novel near-infrared (NIR) luminescent nanoparticle (LNP) with superior brightness. The LNP is used as imaging contrast agent for cellular and small animal imaging and furthermore suggested to use for detecting voltage-sensitive calcium in living cells and animals with high sensitivity. Results: NIR Indocyanine green (ICG) dye was conjugated with human serum albumin (HSA) followed by covalently binding to gold nanorod (AuNR)...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29928489/smad-proteins-directly-suppress-pax2-transcription-downstream-of-transforming-growth-factor-beta-1-tgf-%C3%AE-1-signalling-in-renal-cell-carcinoma
#15
Gagandeep Kaur, Caiyun Grace Li, Andrew Chantry, Cherie Stayner, Julia Horsfield, Michael R Eccles
Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normally expressed during embryonic development, including in the kidney, where it promotes mesenchymal to epithelial transition (MET). PAX2 expression is silenced in many normal adult tissues. However, in contrast, PAX2 is expressed in several cancer types, including kidney, prostate, breast, and ovarian cancer...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928435/matrix-metalloproteinase-12-expression-is-associated-with-tumor-foxp3-regulatory-t-cell-infiltration-and-poor-prognosis-in-hepatocellular-carcinoma
#16
Min-Ke He, Yong Le, Yong-Fa Zhang, Han-Yue Ouyang, Pei-En Jian, Zi-Shan Yu, Li-Juan Wang, Ming Shi
Hepatocellular carcinoma (HCC) is among the most fatal types of cancer worldwide due to its high rates of recurrence and metastasis. The molecular processes involved in HCC progression require further investigation to identify biomarkers for use in diagnosis and treatment. In the present study, the significance and prognostic value of matrix metallopeptidase 12 (MMP12) expression in human HCC was investigated. MMP12 mRNA expression was investigated using reverse transcription-quantitative polymerase chain reaction analysis of 42 pairs of tumor and non-tumor liver tissues obtained from patients with HCC following surgical treatment...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928431/p53-positively-regulates-the-expression-of-cancer-stem-cell-marker-cd133-in-hct116-colon-cancer-cells
#17
Xia Chen, Hua Guan, Xiao-Dan Liu, Da-Fei Xie, Yu Wang, Teng Ma, Bo Huang, Ping-Kun Zhou
Colon cancer stem cells (CSCs), which are highly capable of self-renewal and proliferation, are involved in colon tumorigenesis and response to therapy. CD133 is considered the most robust surface marker for colorectal cancer stem cells. Although the TP53 gene is frequently mutated in colon cancer, it remains not fully understood whether and how tumor protein p53 (p53) is associated with CD133 expression in colon cancer cells. In the present study, the expression of the CSC biomarker CD133 was investigated in terms of p53 status in colorectal carcinoma HCT116 cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928421/the-coordinated-effects-of-apatinib-and-tripterine-on-the-proliferation-invasiveness-and-apoptosis-of-human-hepatoma-hep3b-cells
#18
Huihui Li, Yichang Fan, Fan Yang, Lei Zhao, Bangwei Cao
As a novel vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, Apatinib has exhibited antitumor effects in a variety of solid tumors. Extracts of Chinese herbal medicines have emerged as a promising alternative option to increase the sensitivity of patients to chemotherapeutics while alleviating side effects. The present study aimed to investigate the effects of Apatinib and the traditional Chinese herb Tripterine on the proliferation, invasion and apoptosis of human hepatoma Hep3B cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928419/comparative-proteomics-of-side-population-cells-derived-from-human-hepatocellular-carcinoma-cell-lines-with-varying-metastatic-potentials
#19
Hongzhi Liu, Yingchao Wang, Xiaohua Xing, Ying Sun, Dahai Wei, Geng Chen, Qinying Liu, Shanshan Chen, Xiaolong Liu, Jingfeng Liu
Metastasis and recurrence following surgery are major reasons for the high mortality rate and poor prognosis associated with hepatocellular carcinoma (HCC). Cancer stem cells (CSCs) are thought to be able to cause cancer, and to be the primary cause of tumor recurrence and metastasis. The underlying mechanisms of the metastatic potential of CSCs is poorly understood. In the present study, side population (SP) cells were isolated from 4 HCC cell lines, and their self-renewal and migratory abilities were compared...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928412/tumor-necrosis-factor-related-apoptosis-inducing-ligand-additive-with-iodine-131-of-inhibits-non-small-cell-lung-cancer-cells-through-promoting-apoptosis
#20
Ning Yang, Shuzhan Yao, Dong Liu
Non-small-cell lung cancer (NSCLC) accounts for ~80% of human lung cancer cases and is the most common cause of cancer-associated mortality worldwide. Reports have indicated that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Iodine-131 (I-131) can induce tumor cell apoptosis. The purpose of the present study was to investigate the additive efficacy of TRAIL and I-131 on NSCLC cells. The present study demonstrated that additive treatment of TRAIL and I-131 (TRAIL-I-131) significantly inhibited the growth and aggressiveness of NSCLC cells compared with single TRAIL or I-131 treatment...
July 2018: Oncology Letters
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