keyword
https://read.qxmd.com/read/38205658/application-of-microscopy-and-spectroscopy-in-investigating-anti-cancer-potential-of-achyranthes-aspera-l-leaves
#1
JOURNAL ARTICLE
Huma Bashir, Sehrish Sadia, Zeb Saddiqe, Mubashrah Munir, Xiaohang Bai, Meiyu Jia, Khawaja Shafique Ahmad
The genus Achyranthes belong to the family Amaranthaceae which constitutes an important group of herbs and shrubs with immense medicinal value. The present research work was conducted to investigate the anticancer potential of Achyranthes aspera L. leaves by focusing on the antioxidant, aniproliferative and antimitotic activities of leaf extracts. Plant extraction was carried out by soxhelt method with different solvents. Phytochemical characterization of the plants extracts using chemical methods identified the presence of cardiac glycosides, saponins, coumarins, proteins, tannins, flavonoids and triterpenes...
January 11, 2024: Microscopy Research and Technique
https://read.qxmd.com/read/38130563/molecular-detection-of-secreted-aspartyl-proteinases-saps-from-dental-isolates-of-candida-albicans-and-targeting-with-psidium-guajava-biocompounds-an-in-vitro-and-in-silico-analysis
#2
JOURNAL ARTICLE
Nehal Safiya S, A S Smiline Girija, Vijayashree J Priyadharsini
Introduction Candida albicans  ( C. albicans ) is an opportunistic yeast-like fungus and is considered a functional biome of the oral and gut microbiomes. The  sap  gene and its types play a vital role in the pathogenesis of C. albicans . The emergence of resistance traits is a major problem, and targeting the same with alternative medicines has sparked renewed interest in recent years. Objectives This study is thus aimed at detecting the frequency of sap gene types in the clinical isolates of C...
November 2023: Curēus
https://read.qxmd.com/read/38067531/in-vitro-antibacterial-antioxidant-anticholinesterase-and-antidiabetic-activities-and-chemical-composition-of-salvia-balansae
#3
JOURNAL ARTICLE
Amırat Mokhtar, Tabak Souhila, Bouriah Nacéra, Benabdallah Amina, Mohammed I Alghonaim, Mehmet Öztürk, Sulaiman A Alsalamah, Mohamed Djamel Miara, Fehmi Boufahja, Hamdi Bendif
CONTEXT: Salvia balansae de Noé ( S. balansae ) (Lamiaceae) is known to be an important plant used in folk medicine as an herbal remedy in Algeria. OBJECTIVE: The purpose of the present study was to demonstrate the phytochemical composition, antioxidant activities, enzyme inhibitory activities, and antimicrobial activities of S. balansae extracts. MATERIALS AND METHODS: A methanolic extract and a petroleum ether extract from the aerial parts of the plant were assessed for their chemical composition...
November 27, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37465570/design-synthesis-and-evaluation-of-a-myricetin-and-nobiletin-hybrid-compound-for-alleviating-hyperuricemia-based-on-metabolomics-and-gut-microbiota
#4
JOURNAL ARTICLE
Yan Li, Liu-Yang Pu, Yayun Li, Guanbao Zhu, Zhengzhi Wu
Hyperuricemia (HUA) is the fourth most common basic metabolic disease that can cause damage to multiple organs throughout the body. In this study, a hybrid compound consisting of myricetin and nobiletin was synthesized and its biological activity was evaluated. We named the hybrid compound MNH, and its structure was confirmed by spectroscopy. This study used serum metabolomics profiling with LC/MS and 16S rRNA gene sequencing analysis to explore the anti-HUA efficacy of MNH on a yeast paste-induced mouse model...
July 12, 2023: RSC Advances
https://read.qxmd.com/read/37058123/synergistic-actions-of-three-myb-transcription-factors-underpins-the-high-accumulation-of-myricetin-in-morella-rubra
#5
JOURNAL ARTICLE
Yunlin Cao, Ruining Zhang, Mengyun Xing, Chuanhong Ren, Jiajia Li, Jiafei Qian, Yuyang Mei, Xiaochun Yang, Chongde Sun, Donald Grierson, Kunsong Chen, Changjie Xu, Xian Li
Flavonols are health-promoting bioactive compounds important for human nutrition, health, and plant defense. Transcriptional regulation of kaempferol and quercetin biosynthesis has been studied extensively, while little is known about the regulatory mechanisms underlying myricetin biosynthesis, which has strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. In this study, the flavonol-specific MrMYB12 in Morella rubra preferred activating the promoter of flavonol synthase 2 (MrFLS2) (6...
April 14, 2023: Plant Journal
https://read.qxmd.com/read/36552690/in-vitro-antidiabetic-antioxidant-and-prebiotic-activities-of-the-chemical-compounds-isolated-from-guizotia-abyssinica
#6
JOURNAL ARTICLE
Ahmed Elbermawi, Mohamed Samir Darwish, Ahmed A Zaki, Noha A Abou-Zeid, Mohamed A Taher, Ebtihal Khojah, Somaiah A Bokhari, Amal F Soliman
India and Ethiopia employ Guizotia abyssinica (niger plant) as a source of edible vegetable oil. Previous studies have documented the niger plant's antioxidant properties and dietary benefits. Here, G. abyssinica extract was obtained and ten known bioactive components ( 1 - 10 ) were isolated. The antioxidant, antidiabetic, and prebiotic properties of whole extract and isolated components of niger and the plant's ability to cooperate symbiotically with probiotic strains were examined. Compound 10 , myricetin-3- O -L-rhamnoside, had the highest antioxidant capacity measured in the 2,2-diphenylpicrylhydrazyl (DPPH, 4629...
December 16, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36506532/appraisal-of-selected-ethnomedicinal-plants-as-alternative-therapies-against-onychomycosis-evaluation-of-synergy-and-time-kill-kinetics
#7
JOURNAL ARTICLE
Syeda Aroosa Mohsin, Shazia Shaukat, Marya Nawaz, Tofeeq Ur-Rehman, Nadeem Irshad, Muhammad Majid, Syed Shams Ul Hassan, Simona Bungau, Humaira Fatima
Introduction: This study aims at the biological profiling of Allium sativum , Zingiber officinale , Nigella sativa , Curcuma longa , Mentha piperita , Withania somnifera , Azadirachta indica , and Lawsonia inermis as alternatives against onychomycosis to combat the treatment challenges. Methods: An extract library of aqueous (DW), ethyl acetate (EA), and methanol (M) extracts was subjected to phytochemical and antioxidant colorimetric assays to gauge the ameliorating role of extracts against oxidative stress...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36471760/optimizing-of-the-extraction-conditions-for-anthocyanin-s-from-purple-corn-flour-zea-mays-l-evidences-on-selected-properties-of-optimized-extract
#8
JOURNAL ARTICLE
Mioara Gabriela Slavu Ursu, Ștefania Adelina Milea, Bogdan Păcularu-Burada, Loredana Dumitrașcu, Gabriela Râpeanu, Silvius Stanciu, Nicoleta Stănciuc
In this study, the Response Surface Methodology was used to optimize the extraction conditions for anthocyanins from purple corn flour (PCF), whereas the optimized extract was characterized in terms of phytochemicals content, inhibitory activity against metabolic associated enzymes and the potential to stimulate the metabolic activity of yeasts. The optimized conditions using a Box-Behnken design (BBD) of response surface methodology (RSM) were as follow: temperature (39 °C), extraction time (5 h), liquid/solid ratio (30 mL/g) and ethanol concentration (73 %), yielding a maximum response predicted and experimental values of 13...
March 30, 2023: Food chemistry: X
https://read.qxmd.com/read/36429245/optimization-of-ultrasonic-extraction-of-nutraceutical-and-pharmaceutical-compounds-from-bee-pollen-with-deep-eutectic-solvents-using-response-surface-methodology
#9
JOURNAL ARTICLE
Saffet Çelik, Naciye Kutlu, Yusuf Can Gerçek, Sinan Bayram, Ravi Pandiselvam, Nesrin Ecem Bayram
In recent years, there has been increasing interest in green extraction methods and green solvents due to their many advantages. In this study, the effects of an ultrasonic extraction method and deep eutectic solvents (DESs) on the extraction of different bioactive substances from bee pollen were investigated. In this regard, the effects of process variables such as the molar ratio of the DES (1, 1.5, and 2), sonication time (15, 30, and 45 min), and ultrasonic power (90, 135 and 180 W) on total individual amino acids, total individual organic acids, and total individual phenolic compounds were investigated by response surface methodology (RSM)...
November 15, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36361586/nontoxic-and-naturally-occurring-active-compounds-as-potential-inhibitors-of-biological-targets-in-liriomyza-trifolii
#10
JOURNAL ARTICLE
Israa M Shamkh, Mohammed Al-Majidi, Ahmed Hassen Shntaif, Peter Tan Deng Kai, Ngoc Nh-Pham, Ishrat Rahman, Dalia Hamza, Mohammad Shahbaz Khan, Maii S Elsharayidi, Eman T Salah, Abdullah Haikal, Modupe Akintomiwa Omoniyi, Mahmoud A Abdalrahman, Tomasz M Karpinski
In recent years, novel strategies to control insects have been based on protease inhibitors (PIs). In this regard, molecular docking and molecular dynamics simulations have been extensively used to investigate insect gut proteases and the interactions of PIs for the development of resistance against insects. We, herein, report an in silico study of (disodium 5'-inosinate and petunidin 3-glucoside), (calcium 5'-guanylate and chlorogenic acid), chlorogenic acid alone, (kaempferol-3,7-di-O-glucoside with hyperoside and delphinidin 3-glucoside), and (myricetin 3'-glucoside and hyperoside) as potential inhibitors of acetylcholinesterase receptors, actin, α-tubulin, arginine kinase, and histone receptor III subtypes, respectively...
October 24, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36258662/evolution-of-polyphenolic-anthocyanin-and-organic-acid-components-during-coinoculation-fermentation-simultaneous-inoculation-of-lab-and-yeast-and-sequential-fermentation-of-blueberry-wine
#11
JOURNAL ARTICLE
Jigang Zhang, Ling Fang, Xudong Huang, Zhien Ding, Chuyan Wang
This research aims to investigate the effects of both sequential fermentation and coinoculation fermentation with yeast and lactic acid bacterial (LAB) on the dynamics of changes in basic quality parameters and organic acid, anthocyanin, and phenolic components as well as antioxidant activity during the fermentation of blueberry. The coculture-fermented blueberry wine showed significant decreases in total phenolics, flavonoids, and anthocyanins,by 23.9%, 15.9%, and 13.7%, respectively, as compared with those before fermentation Fermentation changed the contents of organic acids in each group, with a more than 7-fold increase in lactic acid contents as well as a more than 4-fold reduction in quinic acid and malic acid contents...
October 18, 2022: Journal of Food Science
https://read.qxmd.com/read/35997235/the-effect-of-flavonols-in-anacardium-occidentale-l-leaf-extracts-on-skin-pathogenic-microorganisms
#12
JOURNAL ARTICLE
Nurul Shafiqah Hashim, Mei Lan Tan, Kheng Leong Ooi, Shaida Fariza Sulaiman
Cashew ( Anacardium occidentale L.) leaf is traditionally used to treat skin infections. Although many flavonols have been identified from its leaf extract, their inhibitory effects on skin pathogens are not yet determined. The aims of this study were to determine the antimicrobial (against skin pathogenic microbes) and antioxidant activities of four flavonol glycosides from the crude extract and three flavonol aglycones from the hydrolyzed extract. The hydrolyzed extract was found to show higher activities than the crude extract...
August 23, 2022: Natural Product Research
https://read.qxmd.com/read/35941904/luteolin-rich-extract-of-thespesia-garckeana-f-hoffm-snot-apple-contains-potential-drug-like-candidates-and-modulates-glycemic-and-oxidoinflammatory-aberrations-in-experimental-animals
#13
JOURNAL ARTICLE
Uchenna Blessing Alozieuwa, Bashir Lawal, Saidu Sani, Amos Sunday Onikanni, Obinna Osuji, Yunusa Olatunji Ibrahim, Shukurat Bisola Babalola, Gomaa Mostafa-Hedeab, Abdulrahman A Alsayegh, Sarah Albogami, Gaber El-Saber Batiha, Alexander T H Wu, Hsu-Shan Huang, Carlos Adam Conte-Junior
The present study evaluated the polyphenolic contents and hypoglycemic, antioxidant, and anti-inflammatory effects of the diethyl ether fraction of Thespesia garckeana using various in vitro and in vivo models. Total phenol and flavonoid contents of the extract were 613.65 ± 2.38 and 152.83 ± 1.56 mg/100 g dry weight, respectively. The extract exhibited in vitro antioxidant activities against DPPH, FRAP, LPO, and ABTS with respective half-maximal inhibitory concentration (IC50 ) values of 30.91 ± 0.23, 16...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/35890430/flavonoid-rich-fractions-of-bauhinia-holophylla-leaves-inhibit-candida-albicans-biofilm-formation-and-hyphae-growth
#14
JOURNAL ARTICLE
Sara Thamires Dias da Fonseca, Thaiz Rodrigues Teixeira, Jaqueline Maria Siqueira Ferreira, Luciana Alves Rodrigues Dos Santos Lima, Walter Luyten, Ana Hortência Fonsêca Castro
This study evaluated the effect of the extract and fractions of Bauhinia holophylla on Candida albicans planktonic growth, biofilm formation, mature biofilm, and hyphae growth. Three C. albicans strains (SC5314, ATCC 18804, and ATCC 10231) were tested. The crude extract and the fractions were obtained by exhaustive percolation and liquid-liquid partition, respectively. Phytochemical analyses of B. holophylla extract and fractions were performed using high-performance liquid chromatography coupled with a diode-array detector and mass spectrometry (HPLC-DAD-MS)...
July 7, 2022: Plants (Basel, Switzerland)
https://read.qxmd.com/read/35646135/phytochemical-analysis-antioxidant-antimicrobial-and-anti-swarming-properties-of-hibiscus-sabdariffa-l-calyx-extracts-in-vitro-and-in-silico-modelling-approaches
#15
JOURNAL ARTICLE
Bechr Hamrita, Noumi Emira, Adele Papetti, Riadh Badraoui, Lamjed Bouslama, Mohamed-Iheb Ben Tekfa, Assia Hamdi, Mitesh Patel, Abdelbaset Mohamed Elasbali, Mohd Adnan, Syed Amir Ashraf, Mejdi Snoussi
The aim of this study was to investigate the phytochemical composition of dried Roselle calyx ( Hibiscus sabdariffa L.) using both ethanolic and aqueous extracts. We report the antimicrobial activities against a wide range of bacteria, yeast, and fungi. The antioxidant activities were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, and 2-2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging assays. We report also for the first time the effect of the swarming motility in Pseudomonas aeruginosa PAO1...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/35114013/amyloid-protein-induced-sequestration-of-the-eukaryotic-ribosome-effect-of-stoichiometry-and-polyphenolic-inhibitors
#16
JOURNAL ARTICLE
Sehnaz Ferdosh, Senjuti Banerjee, Jayshree Singh, Chandana Barat
Alzheimer's disease (AD) is characterized by the appearance of neurofibrillary tangles comprising of the Tau protein and aggregation of amyloid-β peptides (Aβ 1-40 and Aβ 1-42). A concomitant loss of the ribosomal population is also observed in AD-affected neurons. Our studies demonstrate that, similarly to Tau protein aggregation, in vitro aggregation of Aβ peptides in the vicinity of the yeast 80S ribosome can induce co-aggregation of ribosomal components. The RNA-stimulated aggregation of Aβ peptides and the Tau-K18 variant is dependent on the RNA:protein stoichiometric ratio...
February 3, 2022: FEBS Letters
https://read.qxmd.com/read/34618820/4-coumaroyl-coa-ligases-in-the-biosynthesis-of-the-anti-diabetic-metabolite-montbretin-a
#17
JOURNAL ARTICLE
Frederick G Sunstrum, Hannah L Liu, Sharon Jancsik, Lufiani L Madilao, Joerg Bohlmann, Sandra Irmisch
BACKGROUND: Montbretins are rare specialized metabolites found in montbretia (Crocosmia x crocosmiiflora) corms. Montbretin A (MbA) is of particular interest as a novel therapeutic for type-2 diabetes and obesity. There is no scalable production system for this complex acylated flavonol glycoside. MbA biosynthesis has been reconstructed in Nicotiana benthamiana using montbretia genes for the assembly of MbA from its various different building blocks. However, in addition to smaller amounts of MbA, the therapeutically inactive montbretin B (MbB) was the major product of this metabolic engineering effort...
2021: PloS One
https://read.qxmd.com/read/34177989/-lapt2-gene-encodes-a-flavonoid-prenyltransferase-in-white-lupin
#18
JOURNAL ARTICLE
Jinyue Liu, Yaying Xia, Wenbo Jiang, Guoan Shen, Yongzhen Pang
Legume plants are rich in prenylated flavonoid compounds, which play an important role in plant defense and human health. In the present study, we identified a prenyltransferase (PT) gene, named LaPT2 , in white lupin ( Lupinus albus ), which shows a high identity and close relationship with the other known PT genes involved in flavonoid prenylation in planta. The recombinant LaPT2 protein expressed in yeast cells exhibited a relatively strong activity toward several flavonols (e.g., kaempferol, quercetin, and myricetin) and a relatively weak activity toward flavanone (naringenin)...
2021: Frontiers in Plant Science
https://read.qxmd.com/read/33613054/combined-in-vitro-and-in-silico-approach-to-evaluate-the-inhibitory-potential-of-an-underutilized-allium-vegetable-and-its-pharmacologically-active-compounds-on-multidrug-resistant-candida-species
#19
JOURNAL ARTICLE
V Uma Maheshwari Nallal, R Padmini, B Ravindran, Soon Woong Chang, R Radhakrishnan, Hesham Saleh M Almoallim, Sulaiman Ali Alharbi, M Razia
Candida infections and related mortality have become a challenge to global health. Nontoxic and natural bioactive compounds from plants are regarded as promising candidates to inhibit these multidrug resistant strains. In the present study, in vitro assays and in silico molecular docking approach was combined to evaluate the inhibitory effect of crude extracts from Allium ampeloprasum and its variety A. porrum on Candida pathogens. Phytochemical screening revealed the presence of phenolic acids and flavonoids in higher quantity...
February 2021: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/31412647/comparison-of-physicochemical-microbiological-properties-and-bioactive-compounds-content-of-grassland-honey-and-other-floral-origin-honeys
#20
JOURNAL ARTICLE
Laura Agripina Scripcă, Liliana Norocel, Sonia Amariei
The aim of this study was to compare the physicochemical, the microbiological, and the antioxidant characteristics of unifloral honey, polyfloral honey, honeydew, and hay meadows honey. Hay meadow is type of semi-natural grassland with a great floral diversity, an important resource for pollinators. Grasslands are the source of the spring nectar honey obtained in May and June. Water content, sugars (fructose, glucose, sucrose, trehalose, melezitose, maltose, erlose, turanose, and raffinose), electrical conductivity, phenolic content (gallic acid, protocatechuic acid, 4-hydrxybenzoic acid, vanilic acid, chlorogenic acid, caffeic acid, p-coumaric acid, rosmarinic acid, myricetin, quercitin, luteolin, kaempferol), color, viscosity, and microbiological characteristics were performed for all samples of honey...
August 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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