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https://www.readbyqxmd.com/read/28527285/-genetic-diversity-of-extraintestinal-escherichia-coli-strains-producers-of-beta-lactamases-tem-shv-and-ctx-m-associated-with-healthcare
#1
Yasmin Varela, Beatriz Millán, María Araque
INTRODUCTION: There are few reports from Venezuela describing the genetic basis that sustains the pathogenic potential and phylogenetics of Escherichia coli extraintestinal strains isolated in health care units. OBJECTIVE: To establish the genetic diversity of extraintestinal E. coli strains producers of betalactamases TEM, SHV and CTX-M associated with healthcare. MATERIALS AND METHODS: We studied a collection of 12 strains of extraintestinal E...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28525337/molecular-characterization-and-detection-of-enterotoxins-methicillin-resistance-genes-and-antimicrobial-resistance-of-staphylococcus-aureus-from-fish-and-ground-beef
#2
S Arslan, F Özdemir
A total of 120 samples including 40 freshwaterfish(Oncorhynchus mykiss), 40 seawater fish (Sparus aurata) and 40 ground beef samples were examined for the presence of Staphylococcus aureus. The isolates were identified using biochemical tests and a PCR for the species-specific fragment (Sa442) and thermonuclease gene (nucA). The presence of staphylococcal enterotoxin genes (sea, seb, sec, sed and see), toxin genes (eta, etb, tsst), methicillin resistance gene (mecA) and some phenotypic virulence factors was also tested...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28520999/travel-acquired-esbl-producing-enterobacteriaceae-impact-of-colonization-at-individual-and-community-level
#3
Paul-Louis Woerther, Antoine Andremont, Anu Kantele
Background: Antibiotic resistance is a rapidly increasing global emergency that calls for action from all of society. Intestinal multidrugresistant (MDR) bacteria have spread worldwide with extended-spectrum beta-lactamase (ESBL) -producing Enterobacteriaceae (ESBL-PE) as the most prevalent type. The millions of travelers annually visiting regions with poor hygiene contribute substantially to this spread. Our review explores the underlying data and discusses the consequences of the colonization...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28515902/sites-of-colonization-in-hospitalized-patients-with-infections-caused-by-extended-spectrum-beta-lactamase-organisms-a-prospective-cohort-study
#4
Zeina A Kanafani, Sukayna M Fadlallah, Sarah Assaf, Khalil Anouti, Kohar Annie B Kissoyan, Jad Sfeir, Tamara Nawar, Mohamad Yasmin, Ghassan M Matar
BACKGROUND: The objective of this study was to determine whether patients infected with extended-spectrum beta-lactamase (ESBL)-producing organisms are colonized at multiple body sites. METHODS: This was a prospective cohort study at a tertiary care center in Beirut, Lebanon. Hospitalized patients with infections caused by ESBL-producing organisms were included. Cultures were obtained from the primary site of infection as well as from other sites (skin, nasopharynx, urine, rectum)...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28515215/an-outbreak-of-ndm-1-producing-klebsiella-pneumoniae-in-a-dutch-hospital-with-interspecies-transfer-of-the-resistance-plasmid-and-unexpected-occurrence-in-unrelated-healthcare-centers
#5
Thijs Bosch, Suzanne P M Lutgens, Mirjam H A Hermans, Peter C Wever, Peter M Schneeberger, Nicole H M Renders, Alexander C A P Leenders, Jan A J W Kluytmans, Annelot Schoffelen, Daan Notermans, Sandra Witteveen, Erik Bathoorn, Leo M Schouls
Introduction. In the Netherlands, the number of cases with New Delhi metallo-beta-lactamase (NDM)-positive Enterobacteriaceae is low. Here, we report an outbreak of NDM-1 producing Klebsiella pneumoniae in a Dutch hospital with interspecies transfer of the resistance plasmid and unexpected occurrence in other unrelated healthcare centers (HCCs).Methods. Next-generation sequencing was performed on 250 carbapenemase-producing Enterobacteriaceae isolates including 42 NDM-positive isolates obtained from 29 persons at the outbreak site...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28513576/biofilm-is-a-major-virulence-determinant-in-bacterial-colonization-of-chronic-skin-ulcers-independently-from-the-multidrug-resistant-phenotype
#6
Enea Gino Di Domenico, Ilaria Farulla, Grazia Prignano, Maria Teresa Gallo, Matteo Vespaziani, Ilaria Cavallo, Isabella Sperduti, Martina Pontone, Valentina Bordignon, Laura Cilli, Alessandra De Santis, Fabiola Di Salvo, Fulvia Pimpinelli, Ilaria Lesnoni La Parola, Luigi Toma, Fabrizio Ensoli
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). Nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. Gram-negative bacteria were the most represented microorganisms (60...
May 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28513417/carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-hiv-infected-children-in-zimbabwe
#7
S M S Wilmore, K Kranzer, A Williams, B Makamure, A F Nhidza, J Mayini, T Bandason, J Metcalfe, M P Nicol, I Balakrishnan, M J Ellington, N Woodford, S Hopkins, T D McHugh, R A Ferrand
BACKGROUND: Antimicrobial resistance is an emerging global health issue. Data on the epidemiology of multidrug-resistant organisms are scarce for Africa, especially in HIV-infected individuals who often have frequent contact with healthcare. We investigated the prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in stool among HIV-infected children attending an HIV outpatient department in Harare, Zimbabwe. METHODS: We recruited children who were stable on antiretroviral therapy (ART) attending a HIV clinic from August 2014 to June 2015...
May 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28512093/population-genomic-analysis-of-1-777-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-isolates-houston-texas-unexpected-abundance-of-clonal-group-307
#8
S Wesley Long, Randall J Olsen, Todd N Eagar, Stephen B Beres, Picheng Zhao, James J Davis, Thomas Brettin, Fangfang Xia, James M Musser
Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and mortality rates. The emergence and spread of strains resistant to multiple antimicrobial agents and documented large nosocomial outbreaks are especially concerning. To develop new therapeutic strategies for K. pneumoniae, it is imperative to understand the population genomic structure of strains causing human infections. To address this knowledge gap, we sequenced the genomes of 1,777 extended-spectrum beta-lactamase-producing K...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28511708/enzyme-mediated-formulation-of-stable-elliptical-silver-nanoparticles-tested-against-clinical-pathogens-and-mdr-bacteria-and-development-of-antimicrobial-surgical-thread
#9
Rupak Thapa, Chintan Bhagat, Pragya Shrestha, Suvash Awal, Pravin Dudhagara
BACKGROUND: Silver nanoparticles (AgNPs) are believed to be emerging tool against various infectious diseases including multi-drug resistant (MDR) bacteria. In the present study, in vitro synthesis of AgNPs was optimized using 1:50 ratio of macerozyme (25 μg/μl) and 1 mM AgNO3 incubated at 80 °C for 8 h. AgNPs were characterized by UV-Visible spectroscopy, dynamic light scattering (DLS), scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD)...
May 16, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28508147/identification-of-beta-lactamases-and-beta-lactam-related-proteins-in-human-pathogenic-bacteria-using-a-computational-search-approach
#10
Aniel Jessica Leticia Brambila-Tapia, Ernesto Perez-Rueda, Humberto Barrios, Nory Omayra Dávalos-Rodríguez, Ingrid Patricia Dávalos-Rodríguez, Ernesto Germán Cardona-Muñoz, Mario Salazar-Páramo
A systematic analysis of beta-lactamases based on comparative proteomics has not been performed thus far. In this report, we searched for the presence of beta-lactam-related proteins in 591 bacterial proteomes belonging to 52 species that are pathogenic to humans. The amino acid sequences for 19 different types of beta-lactamases (ACT, CARB, CifA, CMY, CTX, FOX, GES, GOB, IMP, IND, KPC, LEN, OKP, OXA, OXY, SHV, TEM, NDM, and VIM) were obtained from the ARG-ANNOT database and were used to construct 19 HMM profiles, which were used to identify potential beta-lactamases in the completely sequenced bacterial proteomes...
May 16, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28507106/efficacy-and-pharmacokinetics-of-the-combination-of-op0595-and-cefepime-in-a-mouse-model-of-pneumonia-caused-by-esbl-producing-klebsiella-pneumoniae
#11
Norihito Kaku, Kosuke Kosai, Kazuaki Takeda, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Background: OP0595 (RG6080) is a novel diazobicyclooctane that inhibits class A and C serine beta-lactamases. Although the combination of OP0595 and cefepime (FEP) showed good in vitro activity against extended spectrum beta-lactamase (ESBL)-producing pathogens, the effect of the combination therapy against severe infections, such as pneumonia or bacteraemia, remains unknown in vivo.Objectives: In this study, we investigated the efficacy and pharmacokinetics of the combination therapy of OP0595 and FEP in a mouse model of pneumonia caused by Klebsiella pneumoniae harbouring SHV and CTX-M-9-type ESBLs...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28506784/healthcare-personnelintestinal-colonization-with-multidrug-resistant-organisms
#12
Brooke K Decker, Anna F Lau, John P Dekker, Christine D Spalding, Ninet Sinaii, Sean Conlan, David K Henderson, Julia A Segre, Karen M Frank, Tara N Palmore
OBJECTIVES: This study aims to assess the association between patient contact and intestinal carriageof multidrug-resistant organisms (MDRO) by sampling healthcare personnel (HCP) and staff without patient contact. METHODS: For this observational study, we recruited400HCPwho worked in our 200-bed research hospitaland 400 subjectswithout patient contact between November 2013 and February 2015.Participants submitted two self-collected perirectal swabsand a questionnaire...
May 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28503496/prevalence-of-acquired-carbapenemase-genes-in-klebsiella-pneumoniae-by-multiplex-pcr-in-isfahan
#13
Farzin Khorvash, Mohammed Reza Yazdani, Ali Asghar Soudi, Shiva Shabani, Nirvana Tavahen
BACKGROUND: Multi-drug resistant Klebsiella pneumoniae has been considered as a serious global threat. This study was done to investigate carbapenemase producing genomes among K. pneumoniae isolates in Isfahan, Central Iran. MATERIALS AND METHODS: In a cross-sectional study from 2011 to 2012, 29 carbapenem resistant (according to disc diffusion method) carbapenemase producing (according to modified Hodge test) K. pneumoniae strains were collected from Intensive Care Unit (ICUs) of Al-Zahra referral Hospital...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28502397/performance-of-the-check-points-check-mdr-ct103xl-assay-utilizing-the-cdc-fda-antimicrobial-resistance-isolate-bank
#14
Eleanor A Powell, David Haslam, Joel E Mortensen
The Check-MDR CT103XL beta-lactamase assay was validated for use in the clinical microbiology laboratory using two CDC-FDA Antimicrobial Resistant Isolate Bank panels (133 gram-negative bacilli known beta-lactamase genes). The CT103XL detected most reported resistance genes (123 of 136 genes) and additionally identified several resistance genes not reported by the CDC. Discrepant results were confirmed via whole genome sequencing.
April 28, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28499129/occurrence-of-antimicrobial-resistance-bacteria-in-the-yodo-river-basin-japan-and-determination-of-beta-lactamases-producing-bacteria
#15
Naoyuki Yamashita, Yohei Katakawa, Hiroaki Tanaka
Antimicrobial resistant bacteria are widespread in aquatic environments. The aim of the present study was to obtain information on the occurrence of bacteria with antimicrobial resistance and their multiple antimicrobial resistance (MAR) patterns in a river basin in Japan. In addition, the occurrence of fecal bacteria producing extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamase (MBL) in the aquatic environment was determined. Among the Escherichia coli isolates recovered from river samples upstream, 55% isolates were resistant to at least one antimicrobial and 18% were MAR...
May 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28487071/diversity-oriented-sustainable-synthesis-of-antimicrobial-spiropyrrolidine-thiapyrrolizidine-oxindole-derivatives-new-ligands-for-a-metallo-%C3%AE-lactamase-from-klebsiella-pneumonia
#16
Anshu Dandia, Shahnawaz Khan, Pragya Soni, Aayushi Indora, Dinesh Kumar Mahawar, Prateek Pandya, Chetan Singh Chauhan
A simple, environmentally benign and highly proficient microwave assisted one-pot approach for the synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives is reported assembling two pharmacophoric moieties (1,3-indanedione and pyrrolidine/thiapyrrolizidine) in a single molecular framework via three-component 1,3-dipolar cycloaddition reaction of substituted isatin, sarcosine/1,3-thiazoles-4-carboxylic acid and Knoevenagel adduct (2-Cyano-3-phenyl-acrylic acid ethyl ester or 2-Benzylidene-malononitrile) in 2,2,2-trifluoroethanol as a reusable green solvent...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28484498/evaluating-the-trends-of-bloodstream-infections-among-pediatric-and-adult-patients-at-a-teaching-hospital-of-kathmandu-nepal-role-of-drug-resistant-pathogens
#17
Narayan Prasad Parajuli, Hridaya Parajuli, Roshan Pandit, Jyotsna Shakya, Puspa Raj Khanal
Bloodstream infections (BSIs) are among the significant causes of morbidity and mortality for patients of all age groups. However, very little is known about the trends of bacterial bloodstream infections and antimicrobial susceptibilities among pediatric and adult population from Nepal. In this study, we have investigated the different etiological agents responsible for bloodstream infections among pediatric and adult patients and the role of drug resistant organisms in these infections at a tertiary care teaching hospital of Kathmandu, Nepal...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28483962/comparative-analysis-of-extended-spectrum-beta-lactamase-ctx-m-65-producing-salmonella-infantis-isolates-from-humans-food-animals-and-retail-chickens-in-the-united-states
#18
Heather Tate, Jason P Folster, Chih-Hao Hsu, Jessica Chen, Maria Hoffmann, Cong Li, Cesar Morales, Gregory H Tyson, Sampa Mukerjee, Allison C Brown, Alice Green, Wanda Wilson, Uday Dessai, Jason Abbott, Lavin Joseph, Jovita Haro, Sherry Ayers, Patrick F McDermott, Shaohua Zhao
We sequenced the genomes of ten Salmonella enterica serovar Infantis containing blaCTX-M-65 isolated from chicken, cattle, and human sources collected between 2012 and 2015 in the United States through routine NARMS surveillance and product sampling programs. We also completely assembled the plasmids from four of the isolates. All isolates had a D87Y mutation in the gyrA gene and harbored between 7 and 10 resistance genes (aph (4)-Ia, aac (3)-IVa, aph(3' )-Ic, blaCTX-M-65, fosA3, floR, dfrA14, sul1, tetA, aadA1) located in two distinct sites of a megaplasmid (∼316-323kb) similar to that described in a blaCTX-M-65-positive S...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28483952/outcomes-with-ceftazidime-avibactam-in-patients-with-carbapenem-resistant-enterobacteriaceae-cre-infections-a-multi-center-study
#19
Madeline King, Emily Heil, Safia Kuriakose, Tiffany Bias, Vanthida Huang, Claudine El-Beyrouty, Dorothy McCoy, Jon Hiles, Lynette Richards, Julianne Gardner, Nicole Harrington, Kenneth Biason, Jason Gallagher
Ceftazidime-avibactam is a novel cephalosporin-beta-lactamase inhibitor combination that is active against many carbapenem-resistant Enterobacteriaceae (CRE). We describe a retrospective chart review whereby 60 patients received ceftazidime-avibactam for a CRE infection. In hospital mortality was 32%, 53% of patients had microbiological cure, and 65% had clinical success. In this severely ill population with CRE infections, ceftazidime-avibactam was an appropriate option.
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28482925/detection-of-a-ctx-m-group-2-beta-lactamase-gene-in-a-klebsiella-pneumoniae-isolate-from-a-tertiary-care-hospital-trinidad-and-tobago
#20
Paul Cheddie, Francis Dziva, Patrick Eberechi Akpaka
BACKGROUND: Identification of the prevalence and spread of ESBL-mediated antibiotic resistance is essential especially in the hospital setting. It is for this reason, more and more studies are highlighting the importance of complementing phenotypic ESBL-detection techniques with molecular techniques in order to understand the basis and extent of this form of resistance among clinically evolved bacterial populations, especially those belonging to the Enterobacteriaceae family. However, in Trinidad and Tobago and other Caribbean countries, very little is known regarding ESBL detection rates and/or the prevalence of genes conferring ESBL resistance...
May 8, 2017: Annals of Clinical Microbiology and Antimicrobials
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