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https://www.readbyqxmd.com/read/29039302/oxa-48-and-ctx-m-15-extended-spectrum-beta-lactamases-in-raw-milk-in-lebanon-epidemic-spread-of-dominant-klebsiella-pneumoniae-clones
#1
Mohamad Diab, Monzer Hamze, Richard Bonnet, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Raw milk has recently been reported as a source of extended-spectrum beta-lactamase (ESBL) and carbapenemase genes. We thus investigated the prevalence of ESBL- and carbapenemase-producing Enterobacteriaceae in raw milk in Lebanon in order to assess the risk of transfer of these bacteria to humans. A high prevalence (30.2 %) of CTX-M-15-producing K. pneumoniae was detected in raw bovine milk. Three main K. pneumoniae clones were identified by PFGE and MLST typing. Southern blot experiments revealed that one of these clones carried the blaCTX-M-15 gene chromosomally...
October 17, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29038260/meropenem-vaborbactam-resistance-selection-prevention-and-molecular-mechanisms-in-mutants-of-kpc-producing-klebsiella-pneumoniae
#2
Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Michael N Dudley, Olga Lomovskaya
Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify concentrations of both agents associated with selecting or preventing single-step mutations leading to reduced sensitivity to the combination, and to characterize the selected mutations. Eighteen strains of KPC-producing Klebsiella pneumoniae with varying degrees of sensitivity to meropenem (MIC 8-512 μg/ml) and meropenem-vaborbactam (≤0...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29033110/investigating-of-four-main-carbapenem-resistance-mechanisms-in-high-level-carbapenem-resistant-pseudomonas-aeruginosa-isolated-from-burn-patients
#3
Soodabeh Rostami, Ahmad Farajzadeh Sheikh, Saeed Shoja, Abbas Farahani, Mohammad Amin Tabatabaiefar, Abbas Jolodar, Raheleh Sheikhi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen involved in many infections. Carbapenem-resistant P.aeruginosa has emerged as an important cause of infection in different hospitals worldwide. We aimed to determine frequencies of the four main resistance mechanisms [metallo-beta lactamase (MBL) production (blaIMP, blaVIM, blaSPM and blaNDM), overproduction of the MexAB-OprM and MexXY efflux pumps, overproduction of chromosome-encoded AmpC β-lactamase, and reduced OprD expression] in high-level carbapenem-resistant P...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29032522/comparative-characteristic-of-antimicrobial-resistance-in-geriatric-hospital-a-retrospective-cohort-study
#4
G Goltsman, E H Mizrahi, A Leibovitz, G Gal, O Gorelik, E Lubart
BACKGROUND AND AIMS: To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients. METHODS: Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines. RESULTS: Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae were the most common isolates, with proportions of extended spectrum beta-lactamase positivity of 60, 40, and 61% respectively...
October 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29030025/emerge-of-blandm-1-and-blaoxa-48-like-harboring-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-hospitalized-patients-in-southwestern-iran
#5
Zahra Hosseinzadeh, Hadi Sedigh Ebrahim-Saraie, Jamal Sarvari, Jalal Mardaneh, Behzad Dehghani, Seyed Mohammad Hossein Rokni-Hosseini, Mohammad Motamedifar
BACKGROUND: One of the most important emerging carbapenem-resistant bacteria is Klebsiella pneumoniae (K. pneumoniae). The present study aimed to investigate the antibiotic susceptibility pattern of K. pneumoniae isolates and detection of carbapenemase producing K. pneumoniae obtained from Iranian hospitalized patients. METHODS: This cross-sectional study was performed on 211 K. pneumoniae isolates which were recovered from different clinical specimens from 2014 to 2015...
October 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29029187/evidence-for-the-selective-basis-of-transition-to-transversion-substitution-bias-in-two-rna-viruses
#6
Daniel M Lyons, Adam S Lauring
The substitution rates of transitions are higher than expected by chance relative to those of transversions. Many have argued that selection disfavors transversions, as nonsynonymous transversions are less likely to conserve biochemical properties of the original amino acid. Only recently has it become feasible to directly test this selective hypothesis by comparing the fitness effects of a large number of transition and transversion mutations. For example, a recent study of six viruses and one beta-lactamase gene did not find evidence supporting the selective hypothesis...
September 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29028569/occurrence-of-transferable-antibiotic-resistances-in-commercialized-ready-to-eat-mealworms-tenebrio-molitor-l
#7
Andrea Osimani, Federica Cardinali, Lucia Aquilanti, Cristiana Garofalo, Andrea Roncolini, Vesna Milanović, Marina Pasquini, Stefano Tavoletti, Francesca Clementi
The present study aimed to assess the occurrence of transferable determinants conferring resistance to tetracyclines, macrolide-lincosamide-streptogramin B, vancomycin, beta-lactams, and aminoglycosides in 40 samples of commercialized edible mealworms (Tenebrio molitor L.) purchased from European Union (EU) and non-EU producers. A high prevalence of tet(K) was observed in all of the samples assayed, with percentages of PCR-based positivity that ranged from 80% (samples from Thailand) to 100% (samples from the Netherlands, Belgium and France)...
October 5, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29024540/infections-resistance-patterns-and-antibiotic-use-in-patients-at-a-regional-cancer-centre
#8
Nivanka De Silva, Justin Jackson, Christopher Steer
AIMS: To document patient characteristics, infection types, patterns of antibiotic resistance and outcomes in all patients with cancer requiring inpatient management for suspected infection at a regional Australian cancer centre. METHODS: We studied patients ≥ 18 years of age who were admitted under the oncology unit at Albury Wodonga Health during a 12-month period and who had a microbiological test performed for suspected infection during their admission...
October 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29023034/phenotypic-and-molecular-characterization-of-multidrug-resistant-klebsiella-pneumoniae-isolated-from-different-clinical-sources-in-al-najaf-province-iraq
#9
Ahmed Abduljabbar Jaloob Aljanaby, Haneen Mohammed Reda Jaber Alhasnawi
BACKGROUND AND OBJECTIVE: Burns infections and urinary tract infections are the most important prevalent diseases in Asian countries, such as Iraq. Klebsiella pneumoniae is one of the most important bacteria cause this type of infections especially in hospitals. Therefore, the aim of this study was to investigate the prevalence of multi-drug resistance K. pneumoniae and extended-spectrum beta-lactamases producing K. pneumoniae isolates from inpatients with urinary tract infection and burns infections in Al-Kufa hospital in Al-Najaf province, Iraq...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29020364/antimicrobial-resistance-in-gram-negative-rods-causing-bacteremia-in-hematopoietic-stem-cell-transplant-patients-intercontinental-prospective-study-of-infectious-diseases-working-party-of-the-european-bone-marrow-transplantation-group
#10
Diana Averbuch, Gloria Tridello, Jennifer Hoek, Malgorzata Mikulska, Hamdi Akan, Lucrecia Yanez San Segundo, Thomas Pabst, Tülay Özçelik, Galina Klyasova, Irene Donnini, Depei Wu, Zafer Gülbas, Tsila Zuckerman, Aida Botelho de Sousa, Yves Beguin, Aliénor Xhaard, Emmanuel Bachy, Per Ljungman, Rafael de la Camara, Jelena Rascon, Isabel Ruiz Camps, Antonin Vitek, Francesca Patriarca, Laura Cudillo, Radovan Vrhovac, Peter J Shaw, Tom Wolfs, Tracey O'Brien, Batia Avni, Gerda Silling, Firas Al Sabty, Stelios Graphakos, Marja Sankelo, Henrik Sengeloev, Srinivas Pillai, Susanne Matthes, Frederiki Melanthiou, Simona Iacobelli, Jan Styczynski, Dan Engelhard, Simone Cesaro
Background: This intercontinental study aimed to study Gram-negative rods (GNR) resistance in hematopoietic stem cell transplantation (HSCT). Methods: GNR bacteremias occurring during six months post-HSCT (February/2014-May/2015) were prospectively collected, and analysed for rates and risk factors for resistance to fluoroquinolones, non-carbapenem anti-Pseudomonas beta-lactams (non-carbapenems), carbapenems and multidrug-resistance (MDR). Results: Sixty-five HSCT centers from 25 countries (Europe, Australia, Asia) reported data on 655 GNR episodes/704 pathogens in 591 patients (Enterobacteriaceae, 73%; non-fermentatives, 24% and 3% others)...
July 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017750/trends-and-relationship-between-antimicrobial-resistance-and-antibiotic-use-in-xinjiang-uyghur-autonomous-region-china-based-on-a-3-year-surveillance-data-2014-2016
#11
Haishaerjiang Wushouer, Zhao-Xia Zhang, Jian-Hua Wang, Ping Ji, Qing-Fang Zhu, Renagu Aishan, Lu-Wen Shi
PURPOSES: The objective of the study was to identify the trends and relations between antimicrobial resistance (AMR) and antibiotic use in the Xinjiang Uyghur Autonomous Region in Western China from 2014 to 2016. METHODS: A retrospective, descriptive analysis of AMR prevalence, and trends and relations between AMR and antibiotic use during the 3-year period was performed. RESULTS: Third-generation cephalosporin-resistant Escherichia coli was the most prevalent resistant pathogen in terms of both resistance density and resistance proportion...
October 7, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28992981/extended-spectrum-beta-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-from-urinary-tract-infections-evolution-of-antimicrobial-resistance-and-treatment-options
#12
Gemma Jiménez-Guerra, Víctor Heras-Cañas, Lucía Del Carmen Béjar Molina, Antonio Sorlózano-Puerto, José María Navarro-Marí, José Gutiérrez-Fernández
BACKGROUND AND OBJECTIVES: A study of the susceptibility to antimicrobials of the extended spectrum beta-lactamase phenotypes (ESBL) in Escherichia coli and Klebsiella spp. was performed to discover the evolution of this type of resistance from urinary tract infections. MATERIAL AND METHOD: A retrospective study was carried out between 2012 and 2016. Susceptibility to ciprofloxacin, tobramycin, cefoxitin, fosfomycin, nitrofurantoin, co-trimoxazole, and carbapenems was analyzed using MicroScan(®) system...
October 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28991315/-impact-of-rational-use-of-antibiotics-in-a-third-level-clinic-in-colombia
#13
Christian J Pallares, Juan C Cataño
BACKGROUND: The increasing resistance of bacteria to antibiotics threatens the survival of patients and health costs. AIM: To determine the impact of an antimicrobial stewardship program in bacterial resistance and antibiotic consumption. MATERIALS AND METHODS: Quasi experimental study in a third level clinic in the city of Medellin, that evaluate in two time periods (pre-intervention between October 2012 and September 2013 and post intervention between October 2013 and September 2014) the impact of an antimicrobial stewardship program in terms of antibiotic consumption and bacterial ecology...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28989875/bacteriological-profile-of-diabetic-foot-ulcer-with-special-reference-to-drug-resistant-strains-in-a-tertiary-care-center-in-north-east-india
#14
Sudhir K Jain, Rashmisnata Barman
AIM: This study was carried out to determine the bacteriological profile of infected diabetic foot ulcers (DFUs) and the antibiotic resistance pattern from the isolates. An attempt was made to suggest an empiric antibiotic regimen to treat such patients. MATERIALS AND METHODS: Tissue samples were collected from 150 patients between February 2015 and January 2016 with DFUs under aseptic precautions and they were processed as per the Clinical and Laboratory Standards Institute guidelines...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989673/predicting-allosteric-mutants-that-increase-activity-of-a-major-antibiotic-resistance-enzyme
#15
M J Latallo, G A Cortina, S Faham, R K Nakamoto, P M Kasson
The CTX-M family of beta lactamases mediate broad-spectrum antibiotic resistance and are present in the majority of drug-resistant Gram-negative bacterial infections worldwide. Allosteric mutations that increase catalytic rates of these drug resistance enzymes have been identified in clinical isolates but are challenging to predict prospectively. We have used molecular dynamics simulations to predict allosteric mutants increasing CTX-M9 drug resistance, experimentally testing top mutants using multiple antibiotics...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28988698/dissemination-of-successful-international-clone-st15-and-clonal-complex-17-among-bulgarian-ctx-m-15-producing-k-pneumoniae-isolates
#16
Rumyana Markovska, Temenuga Stoeva, Lyudmila Boyanova, Petya Stankova, Daniela Pencheva, Emma Keuleyan, Marianna Murjeva, Marya Sredkova, Dobrinka Ivanova, Grozdanka Lazarova, Gergana Nedelcheva, Radka Kaneva, Ivan Mitov
A total of 82 extended spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae and 4 Klebsiella oxytoca isolates were collected in 2014 from four geographical areas in Bulgaria and their multilocus sequence type (MLST) and transferability of the ESBL encoding genes were investigated. The predominant type was CTX-M-15 (87%), followed by CTX-M-3 (9%), SHV-12 or SHV-2 (2%) and CTX-M-14 (1%). The CTX-M-15 producers belonged to ST15 (34.1%) and to a lesser extent to CC17 (ST16, ST17, ST336). The CTX-M-15 transconjugants showed a presence of R, A/C2 and F replicons...
August 25, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28986323/phenotypic-and-genotypic-detection-of-beta-lactamases-in-acinetobacter-spp-isolates-recovered-from-lebanese-patients-over-a-period-of-one-year
#17
Micheline Hajjar, Elias Dahdouh, Ziad Daoud, Dolla Karam Sarkis
No abstract text is available yet for this article.
October 3, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28984386/pyogenic-liver-abscess-related-to-intrahepatic-bile-duct-stones-difficulties-in-infectious-control-and-diagnosis-of-concomitant-cholangiocarcinoma
#18
Shao-Hua Shi, Xiao-Ning Feng, Zhuo-Yi Wang, Ke Sun, Jing-Feng Xu, Hai-Shen Kong, Shu-Sen Zheng
BACKGROUND AND AIM: Cholangitis, bacteremia and pyogenic liver abscess (PLA) can be often caused by intrahepatic bile ducts stone (IBDS), which is endemic to Southeast Asia. The association between IBDS and cholangiocarcinoma has been well recognized. Concomitant cholangiocarcinoma in the PLA related to IBDS is often missed. METHODS: A case-control study consisting of 64 patients with PLA related to IBDS and 256 control patients with PLA not related to IBDS was used to investigate clinical features of PLA and incidence of concomitant cholangiocarcinoma in patients with PLA related to IBDS...
October 6, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28983007/draft-genome-sequence-of-extended-spectrum-beta-lactamase-producing-serratia-fonticola-bwk15-isolated-from-feces-of-anas-penelope
#19
Takehiko Kenzaka, Katsuji Tani
Migratory birds have been postulated as potential vehicles of antibiotic resistance. Here we isolated the extended-spectrum beta-lactamase (ESBL)-producing Serratia fonticola strain BWK15 from the feces of Anas penelope The strain's draft genome sequence indicated that it harbors class A ESBL, class C beta-lactamase, and many multidrug efflux pumps.
October 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28982134/a-rapid-diagnostic-workflow-for-cefotaxime-resistant-escherichia-coli-and-klebsiella-pneumoniae-detection-from-blood-cultures-by-maldi-tof-mass-spectrometry
#20
Elena De Carolis, Silvia Paoletti, Domenico Nagel, Antonietta Vella, Enrica Mello, Ivana Palucci, Giulia De Angelis, Tiziana D'Inzeo, Maurizio Sanguinetti, Brunella Posteraro, Teresa Spanu
BACKGROUND: Nowadays, the global spread of resistance to oxyimino-cephalosporins in Enterobacteriaceae implies the need for novel diagnostics that can rapidly target resistant organisms from these bacterial species. METHODS: In this study, we developed and evaluated a Direct Mass Spectrometry assay for Beta-Lactamase (D-MSBL) that allows direct identification of (oxyimino)cephalosporin-resistant Escherichia coli or Klebsiella pneumoniae from positive blood cultures (BCs), by using the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technology...
2017: PloS One
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