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https://www.readbyqxmd.com/read/29665444/ndm-1-and-oxa-23-producing-acinetobacter-baumannii-isolated-from-intensive-care-unit-patients-in-tunisia
#1
Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker
Gastrointestinal colonization by carbapenem-resistant Acinetobacter baumannii (CRAB), is a critical step before nosocomial infection. Our objective was to evaluate CRAB intestinal carriage in patients admitted in the intensive care unit (ICU) of a Tunisian Hospital and to determine the antimicrobial resistance mechanisms involved. From December-2014 to February-2015, all 63 patients admitted at the ICU were screened for rectal CRAB-colonization upon admission and once weekly thereafter. ICU-patients who acquired a CRAB-nosocomial-infection were also included...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29663096/plasmids-carrying-dha-1-%C3%AE-lactamases
#2
REVIEW
Claire Hennequin, Viviane Ravet, Frédéric Robin
The aim of this review is to provide an update on the plasmids mediating DHA-1 cephalosporinase in Klebsiella pneumoniae. These plasmids have been mainly found in this bacterium but not only. The first was isolated from Salmonella sp. in France in the early 1990s. They are currently reported worldwide. BlaDHA-1 beta-lactamase gene is usually co-expressed with many other antibiotic resistance genes such as extended-spectrum β-lactamases (blaCTX-M -, bla SHV -types), oxacillinases (blaOXA-1, blaOXA-30 ), penicillinases (bla TEM -type), carbapenemases (bla OXA48 , blaKPC-2 ), aminoglycosides (aacA, aadA, armA), fluoroquinolones (qnrB4, aac6'-1b-cr), and sulfonamide (sul1) resistance genes...
April 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29662260/characterization-of-multidrug-resistant-acinetobacter-ssp-strains-isolated-from-medical-intensive-care-units-in-cali-colombia
#3
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29659796/dissemination-of-multi-resistant-gram-negative-bacteria-into-german-wastewater-and-surface-waters
#4
Heike Müller, Esther Sib, Mike Gajdiss, Ursula Klanke, Franziska Lenz-Plet, Vanessa Barabasch, Cathrin Albert, Anna Schallenberg, Christian Timm, Nicole Zacharias, Ricarda Maria Schmithausen, Steffen Engelhart, Martin Exner, Marijo Parcina, Christiane Schreiber, Gabriele Bierbaum
Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with ESBL (extended spectrum beta-lactamase) producing Gram-negative bacteria, however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant into the receiving surface waters...
April 6, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29656900/risk-factors-for-fecal-carriage-of-imp-6-producing-enterobacteriaceae-at-a-long-term-care-hospital-in-japan-a-follow-up-report-from-the-northern-osaka-multicentre-study-group
#5
Hideharu Hagiya, Norihisa Yamamoto, Ryuji Kawahara, Yukihiro Akeda, Rathina Kumar Shanmugakani, Akiko Ueda, Isao Nishi, Rumiko Asada, Hisao Yoshida, Kazunori Tomono
The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing at medical institutions in Japan without even noticing. Recently, we performed a point prevalence survey for CRE carriage at a medical facility in northern Osaka that demonstrated an unexpectedly high prevalence of blaIMP-6 -positive CRE, particularly at long-term care hospitals (LTCH). To identify the risk factors for CRE carriage, we collected clinical data of patients at a representative LTCH. Of 140 patients who were included in this study, 27 (19...
April 12, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29656053/novel-variant-ndm-11-and-other-ndm-1-variants-in-multidrug-resistant-escherichia-coli-from-south-india
#6
Mohibur Rahman, Chiranjay Mukhopadhyay, Ravi Prakash Rai, Sanjay Singh, Shefali Gupta, Avinash Singh, Ashutosh Pathak, Kashi Nath Prasad
OBJECTIVE: New Delhi metallo-β-lactamase (NDM-1) and its variants mediated carbapenem resistance has raised a major public health concern worldwide. In the present study, we report Escherichia coli positive novel variant i.e. NDM-11 for the first time METHODS: blaNDM were investigated in E. coli by PCR and sequencing. The blaNDM variants were further characterized. The susceptibility patterns of novel blaNDM-11 towards different antibiotics were compared with blaNDM-1 by cloning expressing in E...
April 12, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29651277/new-delhi-metallo-beta-lactamase-producing-enterobacteriaceae-in-south-korea-between-2010-and-2015
#7
Eun-Jeong Yoon, Da Young Kang, Ji Woo Yang, Dokyun Kim, Hyukmin Lee, Kwang Jun Lee, Seok Hoon Jeong
This study was carried out to investigate the epidemiological time-course of New Delhi metallo-beta-lactamase- (NDM-) mediated carbapenem resistance in Enterobacteriaceae in South Korea. A total of 146 non-duplicate NDM-producing Enterobacteriaceae recovered between 2010 and 2015 were voluntarily collected from 33 general hospitals and confirmed by PCR. The species were identified by sequences of the 16S rDNA. Antimicrobial susceptibility was determined either by the disk diffusion method or by broth microdilution, and the carbapenem MICs were determined by agar dilution...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#8
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29643404/canine-napepld-associated-models-of-human-myelin-disorders
#9
K M Minor, A Letko, D Becker, M Drögemüller, P J J Mandigers, S R Bellekom, P A J Leegwater, Q E M Stassen, K Putschbach, A Fischer, T Flegel, K Matiasek, K J Ekenstedt, E Furrow, E E Patterson, S R Platt, P A Kelly, J P Cassidy, G D Shelton, K Lucot, D L Bannasch, H Martineau, C F Muir, S L Priestnall, D Henke, A Oevermann, V Jagannathan, J R Mickelson, C Drögemüller
Canine leukoencephalomyelopathy (LEMP) is a juvenile-onset neurodegenerative disorder of the CNS white matter currently described in Rottweiler and Leonberger dogs. Genome-wide association study (GWAS) allowed us to map LEMP in a Leonberger cohort to dog chromosome 18. Subsequent whole genome re-sequencing of a Leonberger case enabled the identification of a single private homozygous non-synonymous missense variant located in the highly conserved metallo-beta-lactamase domain of the N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD) gene, encoding an enzyme of the endocannabinoid system...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642826/-investigation-of-high-risk-st131-clone-in-esbl-producing-escherichia-coli-isolates-isolated-from-urine-and-non-urinary-clinical-specimens-with-maldi-tof-ms-and-real-time-pcr
#10
Zeynep Çizmeci, Barış Otlu, Elif Aktaş, Seyhan Ördekçi, Özlem Açıkgöz, Nuray Güleç
In recent years, the ST131 clone was identified as a high risk pandemic clone among Escherichia coli isolates by multilocus sequence typing (MLST) studies and has been associated with extended spectrum beta-lactamase (ESBL) production (often with CTX-M-15) and antibiotic resistance especially against fluoroquinolones. The aim of this study was to determine the rate of high risk ST131 clone in ESBL producing E.coli isolates in our region, to investigate the sensitivity of MALDI-TOF MS in the detection of ST131 clone, and to compare the frequency of antimicrobial resistance among ST131 and non-ST131 isolates...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29642825/-investigation-of-carbapenemase-genes-and-molecular-epidemiology-of-enterobacteriaceae-strains-isolated-between-2010-2014-in-a-university-hospitals
#11
Hüseyin Haydar Kutlu, Ebru Us, Alper Tekeli
The worldwide spread of carbapenemase producing Enterobacteriaceae isolates has become a major threat of public health. This worrisome situation leads the development of new methods for carbapenemase screening, detection, prevention of spread and epidemiological data collection as mandatory. In this study, it was aimed to investigate existence and distribution of carbapenemase-encoding genes (CEGs) among carbapenem-resistant Enterobacteriaceae isolated from various clinical samples in Ankara University Faculty of Medicine, Ibni Sina Hospital, Central Microbiology Laboratory between June 2010-May 2014 and detect their clonal relationship...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29619214/multiple-drug-resistance-and-biocide-resistance-in-escherichia-coli-environmental-isolates-from-hospital-and-household-settings
#12
Bothyna Ghanem, Randa Nayef Haddadin
Background: Antibiotic resistance of environmental Escherichia coli in hospitals could be increased due to extensive use of biocides resulting in serious infections. In this study, the prevalence of antibiotic resistance of environmental isolates of E. coli from hospitals and household settings were evaluated and compared. In addition, the association between biocide minimum inhibitory concentration (MIC) and multiple drug resistance (MDR) was investigated. Methods: Environmental samples were collected from different homes and hospitals in Amman, Jordan...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29618675/prevalence-of-escherichia-coli-resistant-to-beta-lactam-antibiotics-among-patients-with-chronic-obstructive-pulmonary-disease-and-urinary-tract-infection
#13
Emilija Nikolić, Tijana Brandmajer, Vesna Bokan, Maria Ulyashova, Maya Rubtsova
Urinary tract infection (UTI), which is typically caused by Escherichia coli (E. coli), is an insufficiently recognized co-morbidity among patients with chronic obstructive pulmonary disease (COPD). Adequate treatment can be complicated by resistance of the causative pathogen to beta-lactam antibiotics, which often produce beta-lactamase enzymes that destroy the antibiotic. The beta-lactamase family of enzymes is extremely diverse, including different types of enzyme and mutant forms. In this study, we analyzed 580 patients with COPD (236 females and 344 males) and thus found 218 patients with co-morbid UTIs, including 58 patients with UTI caused by E...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29618453/report-susceptibility-of-avian-pathogenic-escherichia-coli-from-zoo-birds-in-indonesia-to-antibiotics-and-disinfectants
#14
Sajid Umar, Ana Triana Maiyah, Mehwish Shareef, Hajra Qadir, Qamarun Nisa, Seema Abbas
Antibiotic resistance in avian pathogenic Escherichia coli (APEC) is a common problem in the Indonesian poultry industry. Zoo birds have been postulated as sentinels, reservoirs, and potential spreaders of antibiotic resistance, although much is still unknown about the strains of zoo birds. Disinfection can reduce the infection burden. However, little is known about the presence of resistance against these products. Sixty one APEC strains were isolated from Indonesian zoo birds. The resistance to different classes of antibiotics as well as the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of five disinfectants most often used in the poultry industry was determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29615503/genomic-analysis-of-a-pan-resistant-isolate-of-klebsiella-pneumoniae-united-states-2016
#15
Tom J B de Man, Joseph D Lutgring, David R Lonsway, Karen F Anderson, Julia A Kiehlbauch, Lei Chen, Maroya Spalding Walters, Maria Sjölund-Karlsson, J Kamile Rasheed, Alexander Kallen, Alison Laufer Halpin
Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. Here, we report the genomic characterization of an unusual Klebsiella pneumoniae , nonsusceptible to all 26 antibiotics tested, that was isolated from a U.S. PATIENT: The isolate harbored four known beta-lactamase genes, including plasmid-mediated bla NDM-1 and bla CMY-6 , as well as chromosomal bla CTX-M-15 and bla SHV-28 , which accounted for resistance to all beta-lactams tested...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29615264/extended-spectrum-beta-lactamase-esbl-and-carbapenemase-producing-enterobacteriaceae-in-water-sources-in-lebanon
#16
Mohamad Diab, Monzer Hamze, Richard Bonnet, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Extended-spectrum beta-lactamases (ESBLs) have been recurrently reported in both human and veterinary medicine, and carbapenemases have also emerged in these two sectors. Such resistance phenotypes were increasingly reported in the environment, which both receives and further disseminates multidrug-resistant (MDR) bacteria. Here, we report the high contamination of water samples (68.2%; 15/22) collected in estuaries in Lebanon. From these 15 contaminated sites, a total of 21 ESBL-producing (mostly harbouring the blaCTX-M-15 gene) and four carbapenemase-producing (two blaOXA-48 and two blaOXA-244 ) Enterobacteriaceae were recovered...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29615260/extended-spectrum-beta-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-in-local-and-imported-poultry-meat-in-ghana
#17
Daniel Eibach, Denise Dekker, Kennedy Gyau Boahen, Charity Wiafe Akenten, Nimako Sarpong, Cristina Belmar Campos, Laura Berneking, Martin Aepfelbacher, Ralf Krumkamp, Ellis Owusu-Dabo, Jürgen May
Antibiotic use in animal husbandry has raised concerns on the spread of resistant bacteria. Currently animal products are traded globally with unprecedented ease, which has been challenging the control of antimicrobial resistance. This study aims to detect and characterize extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae from imported and locally produced poultry products sold in Ghana. Local and imported chicken meat was collected from 94 stores and markets throughout Kumasi (Ghana) and cultured on selective ESBL screening agar...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29615167/pseudomonas-aeruginosa-evaluation-of-pathogen-burden-and-drug-resistance-trends-in-a-tertiary-care-hospital
#18
Muhammad Saeed, Farhan Rasheed, Raja Kamran Afzal, Shahida Hussain, Saba Riaz, Adeel Ahmad
OBJECTIVE: To evaluate the pathogen burden and antibiotic-resistance trends of Pseudomonas aeruginosa among hospitalised patients at a tertiary care hospital. STUDY DESIGN: Retrospective, hospital record-based, cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Laboratory, Allama Iqbal Medical College/Jinnah Hospital, Lahore, from January 2014 to December 2016. METHODOLOGY: A total of 5,960 samples were collected from clinically suspected cases of bacterial infections, admitted to the hospital...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29604430/prevalence-and-risk-factors-for-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-french-military-and-civilian-travelers-a-cross-sectional-analysis
#19
Clara Flateau, Sandrine Duron-Martinaud, Rachel Haus-Cheymol, Aurore Bousquet, Déborah Delaune, Cécile Ficko, Audrey Merens, Christophe Rapp
BACKGROUND: International travel is a risk factor for colonization with Extended-Spectrum Beta-Lactamase-producing- Enterobacteriaceae (ESBL-E). We describe the prevalence of and risk-factors for ESBL-E colonization in civilian and military travelers. METHODS: Patients hospitalized in the infectious diseases department of Bégin Military Hospital (France) from May 2012 to November 2015, who had traveled abroad over the past two months, were screened for intestinal colonization with ESBL-E...
March 28, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29600324/a-toolkit-for-the-management-of-infection-or-colonization-by-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-italy-implementation-and-outcome-of-a-european-project
#20
V Mondain, G Secondo, R Guttmann, G Ferrea, A Dusi, M Giacomini, J Courjon, C Pradier
Among European countries, prevalence rates of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are particularly high in those bordering the Mediterranean. This is the case for Italy, with 26% of Escherichia coli displaying resistance to the 3rd generation cephalosporins in 2013. An ESBL-E toolkit designed to assist clinicians in managing patients harboring ESBL-E was favorably implemented in Southern France. In a context of lack of specific Italian recommendations, its extension to an adjacent region of Italy was made possible through a cross-border EU cooperation program...
March 29, 2018: European Journal of Clinical Microbiology & Infectious Diseases
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