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https://www.readbyqxmd.com/read/29234194/an-insight-into-antibiotic-resistance-to-bacterial-infection-in-chronic-liver-disease
#1
Mayank Jain, Joy Varghese, Tom Michael, Chandan Kumar Kedarishetty, Balajee G, Subramanian Swaminathan, Jayanthi Venkataraman
Background: End stage liver disease leads to immune dysfunction which predisposes to infection. There has been a rise in antibiotic resistant infections in these patients. There is scanty data f from India or idea regarding the same. Aim of the study: The present study was undertaken to determine the type of infection acquired and the prevalence of antibiotic resistant infections in cirrhotic patients at a tertiary referral center in South India. Materials and methods: In this retrospective study, all consecutive cirrhotic patients hospitalized between 2011 and 2013 with a microbiologically-documented infection were enrolled...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29233256/analysis-of-oxa-204-carbapenemase-producing-enterobacteriaceae-reveals-possible-endoscopy-associated-transmission-france-2012-to-2014
#2
Anaïs Potron, Sandrine Bernabeu, Gaëlle Cuzon, Valérie Pontiès, Hervé Blanchard, Elise Seringe, Thierry Naas, Patrice Nordmann, Laurent Dortet
OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone...
December 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29229656/informing-future-research-for-carriage-of-multiresistant-gram-negative-bacteria-problems-with-recruiting-to-an-english-stool-sample-community-prevalence-study
#3
Donna M Lecky, Deborah Nakiboneka-Ssenabulya, Tom Nichols, Peter Hawkey, Kim Turner, Keun-Taik Chung, Mike Thomas, Helen Lucy Thomas, Li Xu McCrae, Sahida Shabir, Susan Manzoor, Adela Alvarez-Buylla, Steve Smith, Cliodna McNulty
OBJECTIVES: This study aims to highlight problems with recruiting to an English stool sample community prevalence study. It was part of a larger cross-sectional research to determine the risk factors for the presence of extended-spectrum beta-lactamase and carbapenemase-producing coliforms in stool samples of the asymptomatic general English population. SETTING: Four National Health Service primary care trusts (PCTs) of England representing a different section of the population of England: Newham PCT; Heart of Birmingham Teaching PCT; Shropshire County PCT; and Southampton City PCT...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229643/cystatin-9-and-c-a-novel-immunotherapy-that-protects-against-multi-drug-resistant-new-delhi-metallo-beta-lactamase-1-producing-klebsiella-pneumoniae
#4
Alex J Holloway, JiehJuen Yu, Bernard P Arulanandam, Sarah M Hoskinson, Tonyia Eaves-Pyles
Multidrug-resistant (MDR) bacterial pneumonia can induce dysregulated pulmonary and systemic inflammation leading to morbidity and mortality. Antibiotics to treat MDR pathogens do not function to modulate the extent and intensity of inflammation and can have serious side effects. Herein, we evaluate the efficacy of two human cysteine proteinase inhibitors, cystatin 9 and cystatin C, as a novel immunotherapeutic treatment to combat MDR New Delhi metallo-beta-lactamase-1 (NDM-1) producing Klebsiella pneumoniae (Kp)...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229280/antibiotic-susceptibility-of-neisseria-gonorrhoeae-in-vientiane-lao-pdr
#5
Savandalath Phouangsouvanh, Mayfong Mayxay, Valy Keoluangkhot, Manivanh Vongsouvath, Viengmon Davong, David A B Dance
OBJECTIVES: To determine the antibiotic susceptibility of N. gonorrhoeae in the Lao People's Democratic Republic (Laos). METHODS: We obtained 158 gonococcal isolates from 12,281 genital samples routinely submitted to a diagnostic laboratory in Vientiane, Laos between 2011 and 2015 and determined their susceptibility to five antibiotics by a standard disk diffusion method. RESULTS: The rates of resistance to penicillin (by beta-lactamase production), tetracycline and ciprofloxacin were 89...
December 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29228168/glutamate-residues-at-positions-162nd-and-164th-influence-the-beta-lactamase-activity-of-shv-14-obtained-from-klebsiella-pneumoniae
#6
Gaurav Kumar, Sarmistha Biswal, Soshina Nathan, Anindya S Ghosh
Extensive production of SHV-14 beta-lactamase makes Klebsiella pneumoniae resistant to beta-lactams. The presence of omega-loop has been reported to influence the beta-lactamase activity, which is also present in SHV-14. Its omega-loop has three glutamates in nearly alternating positions, 162, 164 and 167 but their concise role on the behaviour of SHV-14 is unknown. To uncover the influence of each glutamate on SHV-14, we replaced glutamates with alanine and estimated the effect of each mutation by assessing the change in beta-lactam sensitivities in the surrogate Escherichia coli cells and catalytic efficiencies for hydrolysis with the purified proteins...
December 6, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29227744/molecular-epidemiology-of-klebsiella-pneumoniae-strains-causing-bloodstream-infections-in-adults
#7
Meritxell Cubero, Imma Grau, Fe Tubau, Román Pallarés, M Ángeles Domínguez, Josefina Liñares, Carmen Ardanuy
Molecular epidemiology of Klebsiella pneumoniae bacteremic strains allows for a better understanding of preventive and therapeutic strategies. Clinical and microbiological characteristics of 348 K. pneumoniae bacteremia cases (2007-2009) were retrospectively characterized by multilocus sequence typing and extended-spectrum beta-lactamases (ESBL) production. Overall, 223 (64.08%) cases were nosocomial (NA), 58 (16.67%) healthcare associated, and 67 (19.25%) community acquired. The main infection origins were urinary tract (16...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29226171/antimicrobial-resistance-of-sterile-site-infections-in-sub-saharan-africa-a-systematic-review
#8
Meklit Workneh, Morgan J Katz, Mohammed Lamorde, Sara E Cosgrove, Yukari C Manabe
Sparse data exist from sub-Saharan Africa (SSA) on the prevalence of antimicrobial resistance (AMR). A prior review of antimicrobial resistance in SSA from 1990 to 2013 showed a high prevalence of AMR to commonly used antibiotics in this setting. We reviewed the literature published since 2013. Four databases (PubMed, EMBASE, Cochrane, and African Journals Online) were searched for articles between February 2013 and March 2016 with a focus on sterile site infections (bacteremia, urinary tract infections [UTIs], and meningitis)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29224787/global-research-output-in-antimicrobial-resistance-among-uropathogens-a-bibliometric-analysis-2002-2016
#9
Waleed M Sweileh, Samah W Al-Jabi, Sa 'ed H Zyoud, Ansam F Sawalha, Adham S Abu-Taha
BACKGROUND: Antimicrobial resistance (AMR) among uropathogens contributes to treatment failure. Research in AMR among uropathogens is important to establish treatment. The aim of this study was to assess global research trends in AMR among uropathogens. METHODS: Sciverse Scopus was used to retrieve relevant documents for the period from 2002 to 2016. Only journal articles were included in the analysis. Analysis of author keywords was carried out using VOSviewer...
December 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29224318/-distribution-and-drug-resistance-of-pathogens-of-blood-stream-infection-in-patients-with-hematological-malignancies-after-chemotherapy
#10
S Z Chen, K N Lin, M Xiao, X F Luo, Q Li, J H Ren, R Y Huang, M M Chen, Z Z Ally, T Chen, J D Yang, Jianda Hu
Objective: To investigate the distribution and resistance of pathogens isolated from blood cultures in patients with hematological malignancies after chemotherapy in Union Hospital of Fujian Medical University so as to understand the real situation of blood stream infection (BSI) and provide the basis for rational use of antibiotics in clinic. Methods: The data of 657 strains isolated from blood culture specimens of patients with hematological malignancies from January 2013 to December 2016 were collected analyzed...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29222035/carriage-of-esbl-producing-enterobacteriaceae-in-french-hospitals-the-portablse-study
#11
B Pilmis, V Cattoir, D Lecointe, A Limelette, I Grall, A Mizrahi, G Marcade, I Poilane, T Guillard, N Bourgeois Nicolaos, J-R Zahar, A Le Monnier
BACKGROUND: Currently, contact precautions are recommended for patients colonized or infected with extended spectrum beta-lactamase producing enterobacteriaceae (ESBL-PE). Recent studies have challenged this strategy. This study aimed to assess the rate of ESBL-PE faecal carriage among hospitalized patients according to type of hospital ward, and to identify risk factors associated with carriage. METHODS: We conducted a point prevalence study in five different types of hospital wards (medical, surgical, intensive care unit (ICU), after care and rehabilitation and geriatric) in 8 French hospitals...
December 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29220754/association-of-high-mortality-with-extended-spectrum-%C3%AE-lactamase-esbl-positive-cultures-in-community-acquired-infections
#12
Sumit Ray, Dimple Anand, Sankalp Purwar, Arijit Samanta, Kaustubh V Upadhye, Prasoon Gupta, Debashis Dhar
PURPOSE: Infections due to multidrug resistant organisms have become a serious health concern worldwide. The present study was conducted to investigate the spectrum of microbial resistance pattern in the community and their effects on mortality. METHODS: A retrospective review and analysis of prospectively collected data was done of all patients admitted with diagnosis of sepsis in two tertiary care ICU's for a period of two years. Demographics, culture positivity, microbial spectrum, resistance pattern and outcome data were collected...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29215863/near-infrared-laser-excited-nanoparticles-to-eradicate-multidrug-resistant-bacteria-and-promote-wound-healing
#13
Yue Qiao, Fei Ma, Chao Liu, Bo Zhou, Qiaolin Wei, Wanlin Li, Danni Zhong, Yangyang Li, Min Zhou
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial infections, the development of highly effective treatment modalities to inhibit the infections is challenging. Although silver nanoparticles have been intensively applied as an antimicrobial agent for decades, the therapeutic efficacy towards multidrug-resistant bacteria is still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited silver triangular nanoparticles (Tri-Ag) can efficiently kill Gram-negative Escherichia coli (E...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29215330/quantifying-hospital-acquired-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-patients-in-dutch-hospitals
#14
Marjolein F Q Kluytmans-van den Bergh, Suzan P van Mens, Manon R Haverkate, Martin C J Bootsma, Jan A J W Kluytmans, Marc J M Bonten
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014...
December 7, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29214986/antibiotic-resistance-in-enterobacter-cloacae-strains-with-derepressed-partly-derepressed-inducible-ampc-and-extendedspectrum-beta-lactamases-in-zenica-doboj-canton-bosnia-and-herzegovina
#15
Selma Uzunović, Amir Ibrahimagić, Branka Bedenić
Aim To investigate the prevalence of derepressed/partly derepressed/inducible and ESBL/AmpC-producing Enterobacter cloacae isolates and treatment options for infections associated with those isolates. Methods Antibiotic susceptibility was determined by disc diffusion and broth microdilution according to CLSI guidelines. Doubledisk synergy test (DDST) was performed in order to screen for ESBLs and combined disk test with phenylboronic acid to detect AmpC β -lactamases. PCR was used to detect blaESBL/blacarb genes...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29209306/ctx-m-15-producing-e-coli-isolates-from-food-products-in-germany-are-mainly-associated-with-an-incf-type-plasmid-and-belong-to-two-predominant-clonal-e-coli-lineages
#16
Alexandra Irrgang, Linda Falgenhauer, Jennie Fischer, Hiren Ghosh, Elisabet Guiral, Beatriz Guerra, Silvia Schmoger, Can Imirzalioglu, Trinad Chakraborty, Jens A Hammerl, Annemarie Käsbohrer
Extended-spectrum beta-lactamases (ESBL) mediating resistance to 3rd generation cephalosporins are a major public health issue. As food may be a vehicle in the spread of ESLB-producing bacteria, a study on the occurrence of cephalosporin-resistantu Escherichia coli in food was initiated. A total of 404 ESBL-producing isolates were obtained from animal-derived food samples (e.g., poultry products, pork, beef and raw milk) between 2011 and 2013. As CTX-M-15 is the most abundant enzyme in ESBL-producing E. coli causing human infections, this study focusses on E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29207766/successful-management-of-urosepsis-with-ceftriaxone-sulbactam-edta-a-case-report-of-penem-sparing-approach
#17
Amit Bery, Candy Sodhi, Rishu Bhanot
Over the past decade, the Anti-Microbial Resistance (AMR) among members of Enterobacteriaceae family is on rise mainly due to rapid spread of strains producing Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo Beta-Lactamases (MBLs). Hence, the choice of drugs available for these resistant strains is diminishing and their treatment is becoming more challenging. This is a case of complicated Urinary Tract Infection (cUTI) due to ESBL producing E. coli leading to septic shock which was successfully managed with Antibiotic Adjuvant Entity (AAE), a combination of ceftriaxone+sulbactam+EDTA...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207706/detection-of-blactx-m-extended-spectrum-beta-lactamase-producing-salmonella-enterica-serotype-typhi-in-a-tertiary-care-centre
#18
Aishwarya Ramachandran, Mariappan Shanthi, Uma Sekar
Introduction: Infections caused by Salmonella are an important public health threat in tropical and subtropical countries. Due to the emergence of resistance to ampicillin, chloramphenicol and trimethoprim/sulfamethoxazole (multidrug resistant salmonellae) in the late 1980s, fluoroquinolones and extended spectrum cephalosporins became the drugs of choice. Resistance to cefotaxime and ceftriaxone due to the production of Extended Spectrum Beta-Lactamase (ESBL) and reduced susceptibility to ciprofloxacin have emerged resulting in treatment failure...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205195/coexistence-of-metallo-beta-lactamase-encoding-genes-in-pseudomonas-aeruginosa
#19
Lavanya Mohanam, Thangam Menon
BACKGROUND & OBJECTIVES: The emergence and rapid spread of carbapenem resistance mediated by metallo-beta-lactamase (MBL) in Pseudomonas aeruginosa is of major concern due to limited therapeutic options. This study was aimed at detecting the presence of MBL and its association with integrons in imipenem-resistant P. aeruginosa isolates and to determine their genetic relatedness. METHODS: A total of 213 P. aeruginosa isolates were collected from two tertiary care centres and tested against anti-pseudomonal antibiotics by antimicrobial susceptibility testing, followed by the detection of MBL production by combined disk method...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29205194/analysis-of-beta-lactamases-blandm-1phylogeny-plasmid-replicons-in-multidrug-resistant-klebsiella-spp-from-a-tertiary-care-centre-in-south-india
#20
N Nithya, Rabindran Remitha, P R Jayasree, M Faisal, P R Manish Kumar
BACKGROUND & OBJECTIVES: β-lactamases play a predominant role in drug-resistance amongst Enterobacteriaceae. Presence of genes on transferable plasmids encoding these enzymes favours their dissemination across species and genera within and outside geographical boundaries. This study was aimed to understand the presence of β-lactamases and transferable plasmids in clinical isolates of Klebsiella spp. which can contribute to the spread of resistance determinants. METHODS: A total of 41 clinical isolates of Klebsiella spp...
July 2017: Indian Journal of Medical Research
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