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https://www.readbyqxmd.com/read/28420049/the-spectrum-of-neuropsychiatric-lupus-in-a-black-caribbean-population-a-report-of-the-barbados-national-lupus-registry
#1
C Flower, I Hambleton, D Corbin, S Marquez, R Edghill
Objective The objective of this study was to examine neuropsychiatric lupus in a Black Caribbean population. Methods We reviewed Barbados National Lupus Registry patients with ≥4 American College of Rheumatology criteria and a diagnosis of neuropsychiatric lupus using the American College of Rheumatology 19 case definitions. Results From 366 patients with four or more American College of Rheumatology criteria for systemic lupus erythematosus, 55 (15%) had evidence of neuropsychiatric lupus. There were 51 females and four males (F:M = 13:1) with a median age of 31 years...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28400384/stroke-in-systemic-lupus-erythematosus-a-swedish-population-based-cohort-study
#2
Elizabeth V Arkema, Elisabet Svenungsson, Mia Von Euler, Christopher Sjöwall, Julia F Simard
OBJECTIVE: To study the occurrence of ischaemic and haemorrhagic stroke in systemic lupus erythematosus (SLE) compared with the general population by age, sex and time since SLE diagnosis METHODS: Adults with incident SLE were identified from the Swedish National Patient Register (NPR, n=3390) and general population comparators from the Total Population Register were matched on age, sex and county (n=16730). Individuals were followed prospectively until first of death, December 2013, emigration or incident stroke (identified from the NPR, Cause of Death Register and the Stroke Register)...
April 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28394226/stroke-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-risk-factors-clinical-manifestations-neuroimaging-and-treatment
#3
L C D de Amorim, F M Maia, C E M Rodrigues
Neurologic disorders are among the most common and important clinical manifestations associated with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), mainly those that affect the central nervous system (CNS). Risk of cerebrovascular events in both conditions is increased, and stroke represents one of the most severe complications, with an incidence rate between 3% and 20%, especially in the first five years of diagnosis. This article updates the data regarding the risk factors, clinical manifestations, neuroimaging, and treatment of stroke in SLE and APS...
April 2017: Lupus
https://www.readbyqxmd.com/read/28293972/a-comparison-of-patients-and-physicians-assessments-of-disease-activity-using-the-swedish-version-of-the-systemic-lupus-activity-questionnaire
#4
S Pettersson, E Svenungsson, J Gustafsson, S Möller, I Gunnarsson, E Welin Henriksson
OBJECTIVES: We compared patients' assessments of systemic lupus erythematosus (SLE) disease activity by a Swedish version of the Systemic Lupus Activity Questionnaire (SLAQ) with physicians' assessments by the Systemic Lupus Activity Measure (SLAM) and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). We also explored the performance of the SLAQ in patients with short (< 1 year) versus long (≥ 1 year) disease duration. METHOD: Patients filled out the SLAQ before physicians' assessments...
March 15, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28289923/tocilizumab-reverses-cerebral-vasculopathy-in-a-patient-with-homozygous-samhd1-mutation
#5
REVIEW
Michael Henrickson, Heng Wang
An auto-inflammatory syndrome consequent to SAMHD1 mutations involves cerebral vasculopathy characterized by multifocal stenosis and aneurysms within large arteries, moyamoya, chronic ischemia, and early-onset strokes (SAMS). While this condition involves the innate immune system, additional clinical features mimic systemic lupus erythematosus. Mutations in this gene can also cause a subset of the rare genetic condition Aicardi-Goutières syndrome. To date, no established therapy successfully prevents disease progression...
March 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28130684/clinical-characteristics-and-laboratory-findings-of-252-chinese-patients-with-anti-phospholipid-syndrome-comparison-with-euro-phospholipid-cohort
#6
Hui Shi, Jia-Lin Teng, Yue Sun, Xin-Yao Wu, Qiong-Yi Hu, Hong-Lei Liu, Xiao-Bing Cheng, Yu-Feng Yin, Jun-Na Ye, Pojen P Chen, Cheng-de Yang
This study aims to characterize the Chinese Han patients with anti-phospholipid syndrome (APS) and compare the data with those of the Euro-Phospholipid cohort. We conducted a single center study consisting of 252 patients with definite APS from 2000 to 2015. We analyzed the clinical and laboratory characteristics of our cohort and compared the data with those of the Euro-Phospholipid cohort. Our cohort consisted of 216 females and 36 males, with a mean age at entry into this study of 41 years (range 11-74 years)...
March 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28129475/risk-of-myocardial-infarction-and-stroke-in-newly-diagnosed-systemic-lupus-erythematosus-a-general-population-based-study
#7
J Antonio Aviña-Zubieta, Fergus To, Kateryna Vostretsova, Mary De Vera, Eric C Sayre, John M Esdaile
OBJECTIVE: To estimate the future risk and time trends of newly diagnosed myocardial infarction (MI), ischemic stroke, or both (cardiovascular disease [CVD]) in individuals with systemic lupus erythematosus (SLE). METHODS: Using a population-based database that includes all residents of British Columbia, Canada, we conducted a matched cohort study of all patients with incident SLE and up to ten age-, sex-, and entry-time-matched individuals from the general population...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28053276/the-risk-of-cardiovascular-morbidity-and-cardiovascular-mortality-in-systemic-lupus-erythematosus-and-lupus-nephritis-a-danish-nationwide-population-based-cohort-study
#8
Marie-Louise Hermansen, Jesper Lindhardsen, Christian Torp-Pedersen, Mikkel Faurschou, Søren Jacobsen
OBJECTIVE: To assess the role of LN as a risk factor for myocardial infarction (MI), stroke and cardiovascular mortality (CVM) in patients with SLE. METHODS: The study was conducted using individual-level data from multiple nationwide registers. We identified a cohort of patients diagnosed with SLE and further determined if they had a diagnosis of LN during 1995-2011. Each SLE patient was matched with five population controls. Hazard ratios (HRs) were calculated to measure the risk of MI, stroke and CVM in SLE patients relative to population controls and in SLE patients with relative to without LN...
January 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28032050/discrepancies-between-dental-and-medical-records-of-cardiac-patients-in-alhada-armed-forces-hospital-taif-saudi-arabia
#9
Sana M Al Hibshi, Rajaa M Al-Raddadi, Mansour K Assery
AIMS AND OBJECTIVES: This study aims to estimate the prevalence of medical information discrepancies between dental and medical records of cardiac patients at AlHada Armed Forces Hospital in Taif and to identify the factors contributing to these information discrepancies. MATERIALS AND METHODS: The study applied a descriptive retrospective medical and dental records review of a stratified proportional sample of 289 cardiac patients, which was extracted from 1154 cardiac patients who visited both the cardiology and dental clinics at the AlHada Armed Forces Hospital between 2007 and June 2012...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28025216/hydroxychloroquine-for-the-prevention-of-recurrent-cardiovascular-events-in-myocardial-infarction-patients-rationale-and-design-of-the-oxi-trial
#10
Otto Hartman, Petri T Kovanen, Jukka Lehtonen, Kari K Eklund, Juha Sinisalo
Background: Inflammation of the arterial wall plays a central role in the pathogenesis of atherosclerosis. Among patients with rheumatic diseases, anti-rheumatic medication reduces the incidence of cardiovascular (CV) diseases, but only few studies have addressed their cardioprotective effects on patients with no rheumatic diseases. Hydroxychloroquine (HCQ) is an anti-rheumatic drug commonly used in the treatment of rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol levels and the risk of type II diabetes, and has also anti-platelet effects...
April 1, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27914592/hyperuricemia-in-systemic-lupus-erythematosus-is-it-associated-with-the-neuropsychiatric-manifestations-of-the-disease
#11
Mahdi Sheikh, Shafieh Movassaghi, Mohammad Khaledi, Maryam Moghaddassi
OBJECTIVES: To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS: This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was completed for all the participants and the medical records were reviewed regarding the occurrence of arterial or venous thrombotic events, stroke, seizure, depression, headache, psychosis, and peripheral neuropathy...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27899012/disease-outcomes-and-care-fragmentation-among-patients-with-systemic-lupus-erythematosus
#12
Theresa L Walunas, Kathryn L Jackson, Anh H Chung, Karen A Mancera-Cuevas, Daniel L Erickson, Rosalind Ramsey-Goldman, Abel Kho
OBJECTIVE: To examine the impact of care fragmentation across multiple healthcare institutions on disease outcomes in patients with systemic lupus erythematosus (SLE). METHODS: Using the Chicago HealthLNK Data Repository (HDR), an assembly of electronic health records from six institutions, we identified patients with SLE, using ICD-9 codes, whose care was delivered at more than one organization. We examined whether patients had severe infections or comorbidities (ICD-9 code defined) that indicate SLE-induced damage...
November 29, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27843655/moyamoya-disease-with-coexistent-hypertriglyceridemia-in-pediatric-patient
#13
Jacqueline Chan, Fabiola D'Ambrosio Rodriguez, Deepank Sahni, Claudia Boucher-Berry
Moyamoya disease is a rare chronic and progressive cerebrovascular disease of the arteries of the circle of Willis that can affect children and adults. It has been associated with multiple diseases, including immunologic, like Graves' disease, diabetes mellitus, and SLE. Hyperlipidemia has been recognized in patients with Moyamoya disease with an incidence of 27-37%. However, no case in pediatric patients has been reported of the coexistence of Moyamoya disease and hyperlipidemia. Here we present a case of a 9-year-old female diagnosed with Moyamoya disease after a stroke with incidental finding of familial hypercholesterolemia...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27738484/generalized-lymphadenopathy-as-presenting-feature-of-systemic-lupus-erythematosus-case-report-and-review-of-the-literature
#14
Wais Afzal, Talal Arab, Tofura Ullah, Katerina Teller, Kaushik J Doshi
Lymphadenopathy could represent a vast spectrum of etiologies including infectious and non-infectious diseases. Besides proper history taking, physical examination, and laboratory investigations, a tissue diagnosis is often necessary to unmask the cause of generalized lymphadenopathy. Here we present a 23-year-old woman who was admitted for diffuse generalized lymphadenopathy, fatigue, malaise, weight loss, nausea, and bilateral lower extremity edema. She reported a history of seizures as well as stroke 2 years prior with no other medical conditions present...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27703087/cerebral-small-vessel-disease-burden-is-increased-in-systemic-lupus-erythematosus
#15
Stewart J Wiseman, Mark E Bastin, Charlotte L Jardine, Gayle Barclay, Iona F Hamilton, Elaine Sandeman, David Hunt, E Nicole Amft, Susan Thomson, Jill F F Belch, Stuart H Ralston, Joanna M Wardlaw
BACKGROUND AND PURPOSE: Systemic lupus erythematosus (SLE) increases stroke risk, but the mechanism is uncertain. This study aimed to determine the association between SLE and features on neuroimaging of cerebral small vessel disease (SVD), a risk factor for stroke. METHODS: Consecutive patients attending a clinic for SLE were recruited. All patients underwent brain magnetic resonance imaging; had blood samples taken for markers of inflammation, endothelial dysfunction, cholesterol, and autoantibodies; and underwent cognitive and psychiatric testing...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27671837/maternal-cardiovascular-function-at-35-37-weeks-gestation-relation-to-maternal-characteristics
#16
G P Guy, H Z Ling, P Garcia, L C Poon, K H Nicolaides
OBJECTIVE: To examine the possible effects of maternal characteristics and obstetric and medical history on maternal cardiovascular parameters at 35-37 weeks' gestation. METHODS: In 3013 singleton pregnancies at 35-37 weeks, maternal characteristics and medical history were recorded; uterine artery pulsatility index, mean arterial pressure (MAP) and maternal cardiovascular parameters were measured. Multivariable regression analysis was used to determine significant predictors of the cardiovascular parameters among gestational age (GA), maternal characteristics and medical history...
January 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27669670/evaluation-of-american-society-of-anesthesiologists-classification-as-30-day-morbidity-predictor-after-single-level-elective-anterior-cervical-discectomy-and-fusion
#17
Seokchun Lim, Louanne M Carabini, Robert B Kim, Ryan Khanna, Nader S Dahdaleh, Zachary A Smith
BACKGROUND CONTEXT: Higher American Society of Anesthesiologists (ASA) classification is a known predictor of postoperative complication in diverse surgical settings. However, its predictive value is not established in single-level elective anterior cervical discectomy and fusion (SLE-ACDF). PURPOSE: This study aimed to evaluate the predictive value of ASA classification system on 30-day morbidity following SLE-ACDF. DESIGN/SETTING: Patients who underwent SLE-ACDF between 2011 and 2013 were selected from the American College of Surgeons National Surgical Quality Improvement Program database...
March 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27667489/-neuropsychiatric-systemic-lupus-erythematosus
#18
Yoshiya Tanaka
Central nervous system damage, a major organ manifestation of systemic lupus erythematosus (SLE), causes significant morbidity and mortality. Designating this condition as neuropsychiatric SLE (NPSLE), the American College of Rheumatology defines it as involving the central and peripheral nervous systems and being characterized by various manifestations including stroke, seizures, and psychosis. NPSLE treatment mainly seeks to reduce damage accrual. In patients with NPSLE, the use of high-dose corticosteroids is recommended in combination with immunosuppressants, such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy...
September 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27666897/sle-neuropathy-anything-new
#19
Vikram A Londhey
SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, involuntary movements like chorea, myelopathy, acute confusional states, cognitive dysfunction, mood disorder, seizures, psychosis and cranial nerve palsies...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27564390/comorbidities-in-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-systemic-lupus-erythematosus-a-comparative-registries-based-study
#20
Iñigo Rúa-Figueroa, Mónica Fernández Castro, José L Andreu, Carlos Sanchez-Piedra, Víctor Martínez-Taboada, Alejandro Olivé, Javier López-Longo, José Rosas, María Galindo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Fernando Alonso, Beatriz Rodríguez-Lozano, Jesús Alberto García Vadillo, Raúl Menor, Francisco Javier Narváez, Celia Erausquin, Ángel García-Aparicio, Eva Tomero, Sara Manrique-Arija, Loreto Horcada, Esther Uriarte, Susana Gil, Ricardo Blanco, Ruth López-González, Alina Boteanu, Mercedes Freire, Carlos Galisteo, Manuel Rodríguez-Gómez, Elvira Díez-Álvarez, José M Pego-Reigosa
OBJECTIVE: To compare the prevalence of the main comorbidities in 2 large cohorts of patients with primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), with a focus on cardiovascular (CV) diseases. METHODS: This was a cross-sectional multicenter study where the prevalence of more relevant comorbidities in 2 cohorts was compared. Patients under followup from SJOGRENSER (Spanish Rheumatology Society Registry of Primary SS) and RELESSER (Spanish Rheumatology Society Registry of SLE), and who fulfilled the 2002 American-European Consensus Group and 1997 American College of Rheumatology classification criteria, respectively, were included...
January 2017: Arthritis Care & Research
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