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https://www.readbyqxmd.com/read/28330311/scaling-up-a-virginiamycin-production-by-a-high-yield-streptomyces-virginiae-vkm-ac-2738d-strain-using-adsorbing-resin-addition-and-fed-batch-fermentation-under-controlled-conditions
#1
Vakhtang Dzhavakhiya, Vyacheslav Savushkin, Alexander Ovchinnikov, Vladislav Glagolev, Veronika Savelyeva, Evgeniya Popova, Nikita Novak, Elena Glagoleva
Virginiamycin produced by Streptomyces virginiae as a natural mix of macrocyclic peptidolactones M and S is widely used in the industrial production of ethanol fuel and as an antibiotic feed additive for cattle and poultry. Its main antimicrobial components, M1 and S1 factors, act synergistically if the M1:S1 ratio in the final product is 70-75:25-30. This fact significantly complicates the development of stable high-yield strains suitable for industrial application. In the previous work, authors obtained a mutant S...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330277/classical-and-bayesian-predictions-applied-to-bacillus-toxin-production
#2
Karim Ennouri, Rayda Ben Ayed, Maura Mazzarello, Ennio Ottaviani, Fathi Hertelli, Hichem Azzouz
Bacillus thuringiensis is a bacterium with unusual properties that make it useful for pest control in ecoagriculture. It can form a parasporal crystal containing polypeptides (also called delta-endotoxins). These entomopathogenic toxins are made during the stationary phase of the bacterial growth cycle and were initially characterized as an insect pathogen. Nowadays, the use of saturated two-level designs is very popular. This method is especially used in industrial applications where the cost of experiments is expensive...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330163/probing-an-optimal-class-distribution-for-enhancing-prediction-and-feature-characterization-of-plant-virus-encoded-rna-silencing-suppressors
#3
Abhigyan Nath, Karthikeyan Subbiah
To counter the host RNA silencing defense mechanism, many plant viruses encode RNA silencing suppressor proteins. These groups of proteins share very low sequence and structural similarities among them, which consequently hamper their annotation using sequence similarity-based search methods. Alternatively the machine learning-based methods can become a suitable choice, but the optimal performance through machine learning-based methods is being affected by various factors such as class imbalance, incomplete learning, selection of inappropriate features, etc...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330133/bioactive-metabolites-produced-by-streptomyces-cheonanensis-vuk-a-from-coringa-mangrove-sediments-isolation-structure-elucidation-and-bioactivity
#4
Ushakiranmayi Mangamuri, Vijayalakshmi Muvva, Sudhakar Poda, Krishna Naragani, Rajesh Kumar Munaganti, Bhujangarao Chitturi, Venkateswarlu Yenamandra
The strain VUK-A was isolated from a sediment sample of the Coringa mangrove ecosystem was identified as Streptomyces cheonanensis based on morphological, physiological, biochemical and molecular properties. Chemical investigation of the secondary metabolites of the strain Streptomyces cheonanensis VUK-A has led to the segregation of two bioactive compounds, namely 2-Methyl butyl propyl phthalate (1) and Diethyl phthalate (2) using column chromatography. The chemical structure of the active compounds was established on the basis of spectroscopic analysis, including (1)H NMR and (13)C NMR spectroscopies, FTIR and EIMS...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330095/potential-mosquito-repellent-compounds-of-ocimum-species-against-3n7h-and-3q8i-of-anopheles-gambiae
#5
Venugopal Gaddaguti, Talluri Venkateswara Rao, Allu Prasada Rao
Mosquitoes are exceptionally efficient in detecting their hosts for blood meal using odorant binding proteins, viz. 3N7H and 3Q8I and spread several dreadful diseases. DEET is a synthetic mosquito repellent widely used all over world for protection against mosquito bite. Reports reveal that, synthetic mosquito repellents may pose health problems in considerably large population. In view of the above fact, we made an attempt to discover efficient and novel natural mosquito repellent compounds with least impact on human health...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329760/low-temperature-hydrogen-production-from-water-and-methanol-using-pt-%C3%AE-moc-catalysts
#6
Lili Lin, Wu Zhou, Rui Gao, Siyu Yao, Xiao Zhang, Wenqian Xu, Shijian Zheng, Zheng Jiang, Qiaolin Yu, Yong-Wang Li, Chuan Shi, Xiao-Dong Wen, Ding Ma
Polymer electrolyte membrane fuel cells (PEMFCs) running on hydrogen are attractive alternative power supplies for a range of applications, with in situ release of the required hydrogen from a stable liquid offering one way of ensuring its safe storage and transportation before use. The use of methanol is particularly interesting in this regard, because it is inexpensive and can reform itself with water to release hydrogen with a high gravimetric density of 18.8 per cent by weight. But traditional reforming of methanol steam operates at relatively high temperatures (200-350 degrees Celsius), so the focus for vehicle and portable PEMFC applications has been on aqueous-phase reforming of methanol (APRM)...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28329000/trajectory-formation-principles-are-the-same-after-mild-or-moderate-stroke
#7
Denis Mottet, Liesjet Elisabeth Henriette van Dokkum, Jérôme Froger, Abdelkader Gouaïch, Isabelle Laffont
When we make rapid reaching movements, we have to trade speed for accuracy. To do so, the trajectory of our hand is the result of an optimal balance between feed-forward and feed-back control in the face of signal-dependant noise in the sensorimotor system. How far do these principles of trajectory formation still apply after a stroke, for persons with mild to moderate sensorimotor deficits who recovered some reaching ability? Here, we examine the accuracy of fast hand reaching movements with a focus on the information capacity of the sensorimotor system and its relation to trajectory formation in young adults, in persons who had a stroke and in age-matched control participants...
2017: PloS One
https://www.readbyqxmd.com/read/28328986/estimation-of-genetic-parameters-and-genotype-by-environment-interactions-related-to-acute-ammonia-stress-in-pacific-white-shrimp-litopenaeus-vannamei-juveniles-at-two-different-salinity-levels
#8
Xia Lu, Sheng Luan, Baoxiang Cao, Xianhong Meng, Juan Sui, Ping Dai, Kun Luo, Xiaoli Shi, Dengchun Hao, Guomin Han, Jie Kong
Regarding the practical farming of Litopenaeus vannamei, the deterioration of water quality from intensive culture systems and environmental pollution is a common but troublesome problem in the cultivation of this species. The toxicities that result from deteriorating water quality, such as that from ammonia stress, have lethal effects on juvenile shrimp and can increase their susceptibility to pathogens. The toxicity of ammonia plays an important role in the frequently high mortality during the early stage on shrimp farms...
2017: PloS One
https://www.readbyqxmd.com/read/28328196/how-does-pyridine-actually-disassemble-and-assemble-spherical-nucleic-acids
#9
Yoon Hyuck Kim, Ju-Hwan Oh, Abigail Lytton-Jean, Jae-Seung Lee
The spotlighted dual functions of pyridine as a denaturant and as a stabilizer for duplex DNA are thoroughly investigated using spherical nucleic acids (SNAs). At neutral pH, pyridine destabilizes the duplex interconnects of assembled SNAs, result-ing in a gradual decrease in their melting temperature (Tm) as a function of the pyridine concentration. This result is in good agreement with the conventional role of pyridine as a powerful denaturant for free duplex DNA. On the contrary, the addi-tion of pyridine dramatically increases the Tm of hybridized SNAs under acidic conditions, which could be a striking result of pyridine's stabilizing effect for DNA duplex as previously suggested based on the pyridine-nucleobase interactions...
March 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28327976/minion%C3%A2-nanopore-sequencing-of-environmental-metagenomes-a-synthetic-approach
#10
Bonnie L Brown, Mick Watson, Samuel S Minot, Maria C Rivera, Rima B Franklin
Background: Environmental metagenomic analysis is typically accomplished by assigning taxonomy and/or function from whole genome sequencing (WGS) or 16S amplicon sequences. Both of these approaches are limited, however, by read length, among other technical and biological factors. A nanopore-based sequencing platform, MinION™, produces reads that are ≥1×10 4 bp in length, potentially providing for more precise assignment, thereby alleviating some of the limitations inherent in determining metagenome composition from short reads...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28327437/evaluating-the-effect-of-antioxidant-agents-on-shear-bond-strength-of-tooth-colored-restorative-materials-after-bleaching-a-systematic-review
#11
REVIEW
Atiyeh Feiz, Hamid Mosleh, Rahman Nazeri
PURPOSE: The main objective of the present study was to make a systematic review of how antioxidant agents affect shear bond strength of tooth-colored restorative materials after bleaching. DATA SOURCES: Electronic search was used to extract the related articles on the targeted key words such as "antioxidant", "dental bleaching" and "shear bond strength" (SBS) from MeSH, PubMed, Medline, and Cochrane electronic data bases. These articles were all published before 2016...
March 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28327417/appositional-bone-graft-tunneled-technical-note
#12
Roberto Almeida de Azevedo, Felipe Seoane Matos, Leonardo Morais Godoy Figueiredo
INTRODUCTION: A satisfactory positioning of the dental implants is very important in the cosmetic and functional outcome in this treatment for edentulous. Insertion of an endosseous implant in the correct positioning requires sufficient bone volume. Therefore, bone-grafting procedures are becoming increasingly common, especially for the augmentation of horizontally deficient ridges. PRESENTATION OF CASE: Many patients have been treated with this technique of appositional Bone Graft Tunneled at our clinic since 2005...
February 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28327254/moving-forward-with-interdisciplinary-research-on-attractiveness-related-biases
#13
Dario Maestripieri, Andrea Henry, Nora Nickels
In our response, we review and address the comments on our target article made in the 25 commentaries. First, we review and discuss the commentaries that recognized the value of our approach, accepted the main premises and conclusions of our target article, and suggested further avenues for research on attractiveness-related biases. We then respond to commentators who either misinterpreted some parts of our target article or made statements with which we disagree. These commentaries provided us with an opportunity to clarify some aspects of our target article, for example, the fact that we address both the functional significance of attractiveness-related biases and their underlying mechanisms...
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327244/how-should-we-tackle-financial-and-prosocial-biases-against-unattractive-people
#14
Francesca Minerva
The fact that attractive people benefit from their good looks is not bad per se. Rather, what is worrisome is the fact that unattractive people are discriminated against, and that such discrimination negatively affects many aspects of their lives. I focus on the moral implications of this discrimination and on the possible measures that could be taken to alleviate it.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327221/there-is-more-to-memory-than-inaccuracy-and-distortion
#15
Brady Wagoner
Exaggerated claims about inaccuracy and downplaying veracity can also be found in research on memory. This commentary on Jussim's 2012 book analyzes these developments in connection with schema and the misinformation effect's purported role in memory distortion. It concludes by looking back to the locus classicus of memory distortion (viz. Bartlett 1932), which in fact provides a more nuanced account of inaccuracy.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28327144/computational-medical-imaging-and-hemodynamics-framework-for-functional-analysis-and-assessment-of-cardiovascular-structures
#16
REVIEW
Kelvin K L Wong, Defeng Wang, Jacky K L Ko, Jagannath Mazumdar, Thu-Thao Le, Dhanjoo Ghista
Cardiac dysfunction constitutes common cardiovascular health issues in the society, and has been an investigation topic of strong focus by researchers in the medical imaging community. Diagnostic modalities based on echocardiography, magnetic resonance imaging, chest radiography and computed tomography are common techniques that provide cardiovascular structural information to diagnose heart defects. However, functional information of cardiovascular flow, which can in fact be used to support the diagnosis of many cardiovascular diseases with a myriad of hemodynamics performance indicators, remains unexplored to its full potential...
March 21, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28327043/handwashing
#17
Erin Dean
Essential facts Antimicrobial resistance develops when medicines are used inappropriately. Global estimates suggest that every year more than 700,000 people die from drug-resistant strains of common bacterial and viral infections, such as tuberculosis, malaria and HIV. If antimicrobial resistance continues to increase, this number could rise to 10 million a year by 2050.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28327023/stick-to-the-facts
#18
Marc Cornock
There are many instances where someone could be asked to write a report on an incident they were not directly involved in. This could be to obtain an objective overview of the incident or, as a manager of a unit, you may need to gather the views of a number of different people.
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28326998/effects-of-organizational-safety-practices-and-perceived-safety-climate-on-ppe-usage-engineering-controls-and-adverse-events-involving-liquid-antineoplastic-drugs-among-nurses
#19
David M DeJoy, Todd D Smith, Henok Woldu, Mari-Amanda Dyal, Andrea L Steege, James M Boiano
PURPOSE: Antineoplastic drugs pose risks to the healthcare workers who handle them. This fact notwithstanding, adherence to safe handing guidelines remains inconsistent and often poor. This study examined the effects of pertinent organizational safety practices and perceived safety climate on the use of personal protective equipment, engineering controls, and adverse events (spill/leak or skin contact) involving liquid antineoplastic drugs Method: Data for this study came from the 2011 National Institute for Occupational Safety and Health (NIOSH) Health and Safety Practices Survey of Healthcare Workers which included a sample of approximately 1,800 nurses who had administered liquid antineoplastic drugs during the past seven days...
March 22, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28326977/effects-of-buprenorphine-added-to-bupivacaine-infraorbital-nerve-blocks-on-isoflurane-minimum-alveolar-concentration-using-a-model-for-acute-dental-oral-surgical-pain-in-dogs
#20
Lindsey B C Snyder, Christopher J Snyder, Scott Hetzel
Bupivacaine appears to have a duration of action longer than previously reported. Results of this study demonstrate that the addition of buprenorphrine may enhance the analgesic duration of effect for bupivacaine regional nerve blocks. In addition, the use of bupivacaine alone may have analgesia that exceeds 24 hours in many cases. Although not statistically significant based on sample size, 50% of dogs receiving the bupivacaine/buprenorphine regional anesthetic block demonstrated a decreased anesthetic requirement 48 hours postadministration when compared to 25% of dogs receiving the bupivacaine anesthetic...
June 2016: Journal of Veterinary Dentistry
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