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https://www.readbyqxmd.com/read/28817732/enhanced-inflammation-in-new-zealand-white-rabbits-when-mers-cov-reinfection-occurs-in-the-absence-of-neutralizing-antibody
#1
Katherine V Houser, Andrew J Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W Lamirande, Troy Sutton, Kevin W Bock, Mahnaz Minai, Marlene Orandle, Ian N Moore, Kanta Subbarao
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic betacoronavirus that was first detected in humans in 2012 as a cause of severe acute respiratory disease. As of July 28, 2017, there have been 2,040 confirmed cases with 712 reported deaths. While many infections have been fatal, there have also been a large number of mild or asymptomatic cases discovered through monitoring and contact tracing. New Zealand white rabbits are a possible model for asymptomatic infection with MERS-CoV. In order to discover more about non-lethal infections and to learn whether a single infection with MERS-CoV would protect against reinfection, we inoculated rabbits with MERS-CoV and monitored the antibody and inflammatory response...
August 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28817674/new-insights-into-the-distribution-protein-abundance-and-subcellular-localisation-of-the-endogenous-peroxisomal-biogenesis-proteins-pex3-and-pex19-in-different-organs-and-cell-types-of-the-adult-mouse
#2
Claudia Colasante, Jiangping Chen, Barbara Ahlemeyer, Rocio Bonilla-Martinez, Srikanth Karnati, Eveline Baumgart-Vogt
Peroxisomes are ubiquitous organelles mainly involved in ROS and lipid metabolism. Their abundance, protein composition and metabolic function vary depending on the cell type and adjust to different intracellular and environmental factors such as oxidative stress or nutrition. The biogenesis and proliferation of these important organelles are regulated by proteins belonging to the peroxin (PEX) family. PEX3, an integral peroxisomal membrane protein, and the cytosolic shuttling receptor PEX19 are thought to be responsible for the early steps of peroxisome biogenesis and assembly of their matrix protein import machinery...
2017: PloS One
https://www.readbyqxmd.com/read/28817633/fat-storage-in-drosophila-suzukii-is-influenced-by-different-dietary-sugars-in-relation-to-their-palatability
#3
Maurizio Biolchini, Elisabetta Murru, Gianfranco Anfora, Francesco Loy, Sebastiano Banni, Roberto Crnjar, Giorgia Sollai
The peripheral sensitivity and palatability of different carbohydrates was evaluated and their nutritional value assessed in adult females of D. suzukii by means of an electrophysiological, behavioural and metabolic approach. The electrophysiological responses were recorded from the labellar "l" type sensilla stimulated with metabolizable mono- and disaccharides (glucose and maltose) and a non-metabolizable sugar (sucralose); the response rating and the palatability to the same sugars, evaluated by recording the proboscis extension reflex (PER), was maltose>glucose>sucralose...
2017: PloS One
https://www.readbyqxmd.com/read/28817601/bortezomib-initiates-endoplasmic-reticulum-stress-elicits-autophagy-and-death-in-echinococcus-granulosus-larval-stage
#4
María Celeste Nicolao, Julia A Loos, Christian Rodriguez Rodrigues, Viviana Beas, Andrea C Cumino
Cystic echinococcosis (CE) is a worldwide distributed helminthic zoonosis caused by Echinococcus granulosus. Benzimidazole derivatives are currently the only drugs for chemotherapeutic treatment of CE. However, their low efficacy and the adverse effects encourage the search for new therapeutic targets. We evaluated the in vitro efficacy of Bortezomib (Bz), a proteasome inhibitor, in the larval stage of the parasite. After 96 h, Bz showed potent deleterious effects at a concentration of 5 μM and 0.5 μM in protoscoleces and metacestodes, respectively (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28817580/criticality-predicts-maximum-irregularity-in-recurrent-networks-of-excitatory-nodes
#5
Yahya Karimipanah, Zhengyu Ma, Ralf Wessel
A rigorous understanding of brain dynamics and function requires a conceptual bridge between multiple levels of organization, including neural spiking and network-level population activity. Mounting evidence suggests that neural networks of cerebral cortex operate at a critical regime, which is defined as a transition point between two phases of short lasting and chaotic activity. However, despite the fact that criticality brings about certain functional advantages for information processing, its supporting evidence is still far from conclusive, as it has been mostly based on power law scaling of size and durations of cascades of activity...
2017: PloS One
https://www.readbyqxmd.com/read/28817469/the-right-tool-for-the-job-choosing-between-covariate-balancing-and-generalized-boosted-model-propensity-scores
#6
Claude M Setodji, Daniel F McCaffrey, Lane F Burgette, Daniel Almirall, Beth Ann Griffin
Estimating the causal effect of an exposure (versus some control) on an outcome using observational data often requires addressing the fact that exposed and control groups differ on pre-exposure characteristics that may be related to the outcome (confounders). Propensity score methods have long been used as a tool for adjusting for observed confounders in order to produce more valid causal effect estimates under the strong ignorability assumption. In this article, we compare two promising propensity score estimation methods (for time invariant binary exposures) when assessing the average treatment effect on the treated: the generalized boosted models and covariate-balancing propensity scores, with the main objective to provide analysts with some rules-of-thumb when choosing between these two methods...
August 16, 2017: Epidemiology
https://www.readbyqxmd.com/read/28817355/total-training-load-may-explain-similar-strength-gains-and-muscle-hypertrophy-seen-in-aged-rats-submitted-to-resistance-training-and-anabolic-steroids
#7
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Danilo Bocalini, Ricardo Aparecido Baptista Nucci, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to quantify training parameters and analyze the morphological response of aged muscles submitted to resistance training and anabolic steroids. Aged Wistar rats were divided into groups: C - initial control; CF - final control; CAS - control with anabolic steroid, RT - resistance training, and RTA - resistance training with anabolic steroid. Maximum carried load, absolute and relative loads increased significantly in RT and RTA. RTA demonstrated greater relative load than RT. Average total volume, total climbing volume, relative total volume, relative total climbing volume, and mean climbing volume were similar between groups RT and RTA...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28817254/highly-001-textured-tetragonal-bifeo3-film-and-its-photoelectrochemical-behaviors-tuned-by-magnetic-field
#8
Haomin Xu, Yuanhua Lin, Takashi Harumoto, Ji Shi, Ce-Wen Nan
Highly (001)-textured BiFeO3 film in tetragonal phase (T-BFO) with a giant c/a ratio was firstly obtained on quartz/polycrystalline ITO substrate. Our results indicate that the polycrystalline ITO layer with small surface roughness is a critical point to control the growth of T-BFO structure. It should be ascribed to the fact that a Bi-rich phase interlayer (~5 nm) could be formed on ITO, which acted as a crystal seed layer and thus induced the growth of (001)-textured T-BFO structure. The observed weak room temperature ferromagnetism should be attributed to Fe valance change...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28817189/from-preparedness-to-risk-from-the-singular-risk-of-nuclear-war-to-the-plurality-of-all-hazards
#9
Joe Deville, Michael Guggenheim
Debates on risk have largely assumed risk to be the outcome of calculative practices. There is a related assumption that risk objects come only in one form, and that the reason not everything can be transformed into a risk is because of the difficulties in calculating and creating universal quantitative comparisons. In this article, building on recent studies of preparedness that have broadened understandings of risk, we provide an analysis of how preparedness measures might themselves produce risk, in particular through risk's durable instantiation, or what we call 'concretization'...
August 17, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28817182/centralized-patient-reported-outcome-data-collection-in-transplantation-is-feasible-and-clinically-meaningful
#10
Bronwen E Shaw, Ruta Brazauskas, Heather R Millard, Rachel Fonstad, Kathryn E Flynn, Amy Abernethy, Jenny Vogel, Charney Petroske, Deborah Mattila, Rebecca Drexler, Stephanie J Lee, Mary M Horowitz, J Douglas Rizzo
BACKGROUND: Allogeneic hematopoietic cell transplantation (HCT) cures many patients, but often with the risk of late effects and impaired quality of life. The value of quantifying patient-reported outcomes (PROs) is increasingly being recognized, but the routine collection of PROs is uncommon. This study evaluated the feasibility of prospective PRO collection by an outcome registry at multiple time points from unselected HCT patients undergoing transplantation at centers contributing clinical data to the Center for International Blood and Marrow Transplant Research (CIBMTR), and then it correlated the PRO data with clinical and demographic data...
August 17, 2017: Cancer
https://www.readbyqxmd.com/read/28816710/establishment-of-primary-cell-culture-from-ascitic-fluid-and-solid-tumor-obtained-from-epithelial-ovarian-carcinoma-patients
#11
Rajarshi Kar, Diwesh Chawla, Bindiya Gupta, Mohit Mehndiratta, Neelam Wadhwa, Rachna Agarwal
OBJECTIVE: Ovarian cancer is the seventh leading cause of cancer death worldwide. This is mainly due to late diagnosis and high rate of relapse and resistance following chemotherapy. In the present study, we describe simple and cost-effective method to establish primary culture from ascitic fluid and solid tumor obtained from epithelial ovarian carcinoma patient, which may provide a better tool for in vitro testing of drug sensitivity and designing individualized treatment protocol. METHODS: Complete Dulbecco modified Eagle medium (DMEM) was prepared by supplementing DMEM with 10% fetal bovine serum and antibiotics (ciprofloxacin and amphotericin B)...
August 16, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28816621/use-disuse-paradigms-are-ubiquitous-concepts-in-characterizing-the-process-of-inheritance
#12
Sophie Juliane Veigl
In recent years, a Lamarckian theme has found its way back into academic discourse on evolution and inheritance. Especially the emerging field of transgenerational small RNAs has provided at least a proof of concept for the inheritance of acquired traits. Yet it remains unclear whether the Lamarckian concept of inheritance will in fact have its rennaisance or whether it will remain the rallying cry for the outlaws, heretics and enfants terribles of molecular biology. As unclear as the future of Lamarckian theory is its content and reference...
August 17, 2017: RNA Biology
https://www.readbyqxmd.com/read/28816518/balancing-between-prejudice-and-fact-for-gaming-disorder-does-the-existence-of-alcohol-use-disorder-stigmatize-healthy-drinkers-or-impede-scientific-research
#13
Seung-Yup Lee, Hyekyung Choo, Hae Kook Lee
The inclusion of Gaming Disorder (GD) criteria in the 11th Revision of the International Classification of Diseases (ICD-11) beta draft was recently criticized, and an argument was made for its removal to "avoid a waste of public resources." However, these misleading statements are believed to be based on under estimation of this ever-growing problem. Such claims may endanger public health and the psychosocial well-being of affected individuals. Thus, the seriousness of the problem was briefly emphasized in our response paper...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28816496/icd-11-gaming-disorder-needed-and-just-in-time-or-dangerous-and%C3%A2-much%C3%A2-too%C3%A2-early
#14
Wim van den Brink
In their debate contribution, Aarseth et al. (2016) strongly argue against the proposal of WHO ICD-11 (International Classification of Diseases, 11th revision) to include Gaming Disorder as a new diagnostic category emphasizing the fact that no consensus exists on the definition and the risk that gaming will be demonized and gamers stigmatized resulting in a tsunami of false positive referrals to treatment. In this commentary, it is argued that gaming is indeed just another relatively innocent recreational activity with only a small minority losing control resulting in gaming-related problems...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28816178/plasmon-modes-of-bilayer-molybdenum-disulfide-a-density-functional-study
#15
Zahra Torbatian, Reza Asgari
We explore the collective electronic excitations of bilayer molybdenum disulfide (MoS2 ) using the density functional theory together with the random phase approximation. The many-body dielectric function and electron energy-loss spectra are calculated using an ab initio based model involving material-realistic physical properties. The electron energy-loss function of bilayer MoS2 system is found to be sensitive to either electron or hole doping and it is owing to the fact that the Kohn-Sham band dispersions are not symmetric for energies above and below the zero Fermi level...
August 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28816093/vascular-complications-following-intra-aortic-balloon-pump-implantation-an-updated-review
#16
Monique M de Jong, Roberto Lorusso, Fatima Al Awami, Francesco Matteuci, Orlando Parise, Pieter Lozekoot, Massimo Bonacchi, Jos G Maessen, Daniel M Johnson, Sandro Gelsomino
BACKGROUND: The use of the intra-aortic balloon pump (IABP) as a support device remains controversial due to the fact that a number of studies have shown no benefit in end mortality whilst using this device. One of the reasons for this could be the increase in vascular complications when using the pump. Therefore, the aim of the present review was to assess the current literature available with regards to IABP vascular complications during the clinical situation. METHODS: A literature search was performed, searching for IABP complications in adult human studies between 1990 and 2016...
August 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28816031/do-you-see-what-i-see-a-mother-s-plea
#17
Kees Nydam, Rebecca Soole
There is sometimes dissonance between the medical services that the general public expects an ED to provide and the acute critical care that emergency clinicians hope to provide. One explanation for this is that the ED is both a territory and a meeting place for a cornucopia of clinicians, some of whom are not ED clinicians themselves. Roles are sometimes ambiguous and location-specific. Recently, one Queensland mother believed that her son's suicide could have been prevented had emergency staff been better educated...
August 16, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28815811/study-of-the-effects-of-spray-drying-in-whey-starch-on-the-probiotic-capacity-of-lactobacillus-rhamnosus-64-in-the-gut-of-mice
#18
L Lavari, P Burns, R Páez, J Reinheimer, G Vinderola
AIMS: To evaluate the effects of spray-drying of Lactobacillus rhamnosus 64 on its capacity to modulate the gut immune response and on the attenuation of TNBS-induced colitis in mice. METHODS AND RESULTS: L. rhamnosus 64 was spray-dried in cheese whey-starch solution and administered to mice for three, six or ten consecutive days. Peritoneal macrophage phagocytic activity, secretory-IgA (S-IgA) levels in the small intestinal fluid and TNFα, IFNγ, IL-10, IL-6 and IL-2 levels in homogenates of the small and large intestine were determined...
August 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28815750/title-learning-theories-and-tools-for-the-assessment-of-core-nursing-competencies-in-simulation-a-theoretical-review
#19
REVIEW
Patrick Lavoie, Cécile Michaud, Marilou Bélisle, Louise Boyer, Émilie Gosselin, Myrian Grondin, Caroline Larue, Stéphan Lavoie, Jacinthe Pepin
AIM: To identify the theories used to explain learning in simulation and to examine how these theories guided the assessment of learning outcomes related to core competencies in undergraduate nursing students. BACKGROUND: Nurse educators face the challenge of making explicit the outcomes of competency-based education, especially when competencies are conceptualized as holistic and context-dependent. DESIGN: Theoretical review. DATA SOURCES: Research papers (N=182) published between 1999 - 2015 describing simulation in nursing education...
August 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28815528/alzheimer-disease
#20
Estela Area-Gomez, Eric A Schon
The most widely accepted hypothesis to explain the pathogenesis of Alzheimer disease (AD) is the amyloid cascade, in which the accumulation of extraneuritic plaques and intracellular tangles plays a key role in driving the course and progression of the disease. However, there are other biochemical and morphological features of AD, including altered calcium, phospholipid, and cholesterol metabolism and altered mitochondrial dynamics and function that often appear early in the course of the disease, prior to plaque and tangle accumulation...
2017: Advances in Experimental Medicine and Biology
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