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Huili Wei, Hua Qu, Hang Wang, Huacong Deng
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results...
2016: Journal of Diabetes Research
J X Ma, M Zhou, L L Xiao
No abstract text is available yet for this article.
July 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Yasodha Krishnasamy, Venkat K Ramshesh, Monika Gooz, Rick G Schnellmann, John J Lemasters, Zhi Zhong
BACKGROUND AND AIM: Because ethanol consumption is commonly associated with a high cholesterol diet, we examined whether combined consumption of ethanol and high cholesterol increases liver injury and fibrosis. METHODS: Male C57BL/6J mice were fed diets containing: 1) 35% of calories from corn oil (CTR), 2) CTR plus 0.5% (w/v) cholesterol (Chol), 3) CTR plus ethanol (27% of calories) (EtOH), or 4) EtOH+Chol for 3 months. RESULTS: In mice fed Chol or EtOH alone, ALT increased to ~160 U/L, moderate hepatic steatosis occurred, and leukocyte infiltration, necrosis, and apoptosis increased modestly, but no observable fibrosis developed...
2016: PloS One
Zhanke Wang, Rongjian Chen, Zhongzhen Zhu, Xiaoyun Zhang, Shiliang Wang
BACKGROUND: Inflammation response and oxidative stress promote the occurrence and development of multiple-organ dysfunction syndrome (MODS). METHODS: Eighty MODS rats with third-degree burns were divided randomly into 4 groups: insulin, ethyl pyruvate (EP), insulin combined with EP, and control. Blood levels of glucose, alanine aminotransferase (ALT), creatine (CRE), creatine kinase (CK), tumor necrosis factor α (TNF-α), high-mobility group box 1 (HMGB-1), malondialdehyde (MDA), and total antioxidant capacity (TAC) before as well as 1, 3, 5, and 7 days after burns were measured...
August 9, 2016: American Journal of Emergency Medicine
B Yang, W D Zhang, Y M Xia, Z P Zhang, L Li, L Zhang, W C Wang, Z D Wang, X P Li
OBJECTIVE: To analyze the role of oxycodone in acute lung injury(ALI) induced by lipopolysaccharide (LPS) in rats. METHODS: Male SD rats were randomly allocated into 4 groups: control group, oxycodone group, LPS group, LPS+ oxycodone group. The effects of oxycodone on LPS-induced neutrophils influx, inflammatory cytokines release, pulmonary edema, apoptotic cell were examined. In addition, the toll-like receptor 4 (TLR4) in lung tissues was detected by Western blotting...
August 16, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Luis C Berrocal-Almanza, Surabhi Goyal, Abid Hussain, Tilman E Klassert, Dominik Driesch, Zarko Grozdanovic, Gadamm Sumanlatha, Niyaz Ahmed, Vijayalakshmi Valluri, Melanie L Conrad, Nickel Dittrich, Ralf R Schumann, Birgit Lala, Hortense Slevogt
Pulmonary tuberculosis (PTB) results in lung functional impairment and there are no surrogate markers to monitor the extent of lung involvement. We investigated the clinical significance of S100A12 and soluble receptor for advanced glycation end-products (sRAGE) for predicting the extent of lung involvement. We performed an observational study in India with 119 newly diagnosed, treatment naïve, sputum smear positive, HIV-negative PTB patients and 163 healthy controls. All patients were followed-up for six months...
2016: Scientific Reports
Mizuki Kuramochi, Takeshi Izawa, Munmun Pervin, Alexandra Bondoc, Mitsuru Kuwamura, Jyoji Yamate
Drug-induced liver injury (DILI) is a common problem in human medicine and it is a major reason to withdraw marketed drugs. However, the mechanism of DILI is still less known. Damage-associated molecular patterns (DAMPs), such as high-mobility group boxes (HMGBs), S100 proteins and heat shock proteins (HSPs), are released from injured or necrotic cells, bind to toll-like receptors (TLRs) and modulate inflammatory reactions. Here we investigated the kinetics of DAMPs, TLRs and MHC class II in a rat model of DILI with thioacetamide (TAA)...
September 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
Xiaodi Tian, Zhong Wang, Gang Chen
High mobility group box-1 (HMGB1), a highly conserved nonhistone nuclear protein, is widely expressed in most eukaryotic cells including neural cells. Nuclear HMGB1 stabilize nucleosome formation and facilitates gene transcription. HMGB1 can be passively released from necrotic cells or actively secreted from stimulated immune cells. Extracellular HMGB1 interacts with receptors, including the receptor for advanced glycation endproducts (RAGEs), Toll-like receptor 2 (TLR2) and TLR4. After brain injury, HMGB1 is released early from neural cells and contribute to the early stages of the inflammatory response...
August 8, 2016: Current Drug Delivery
Zhao Xin-Peng, Hu Yong-Hua, Liu Yong, Wang Jing-Jing, Wang Guang-Hua, Wang Ren-Jie, Zhang Min
High-mobility group box (HMGB) 1 is a chromosomal protein that plays critical roles in DNA transcription, replication and repair. In addition, HMGB1 functions as a pro-inflammatory molecule in many vertebrates and invertebrates. In teleosts, very limited studies of HMGB1 have been reported. In this study, we identified a HMGB1 homologue (SsHMGB1) from black rockfish (Sebastes schlegelii) and analyzed its structure, expression and biological function. The open reading frame of SsHMGB1 is 621 bp, with a 5'-untranslated region (UTR) of 62 bp and a 3'-UTR of 645 bp...
September 2016: Fish & Shellfish Immunology
Valeria Bortolotto, Mariagrazia Grilli
Since its initial discovery, current understanding on the functional role of the Receptor for Advanced Glycation End-products (RAGE) in physiology and in pathology has impressively grown, especially in consideration of its large ligand repertoire (AGEs, HMGB-1, β amyloid, S100B/S100A12) and its potential involvement in the pathophysiology of several chronic human disorders. Downstream RAGE engagement by its ligands, NF-κB signaling activation has been demonstrated in several cell phenotypes, including neurons and glia...
August 3, 2016: CNS & Neurological Disorders Drug Targets
Motofumi Torikai, Satoshi Ibara, Satoshi Ieiri, Takashi Hamada, Hiroyuki Noguchi, Kazunobu Sueyoshi, Takeo Fukuda, Kazuhiro Abeyama
PURPOSE: Intestinal perforation (IP) is a fatal complication in extremely low birth weight infants (ELBWI). We started administrating enteral miconazole (MCZ) to ELBWI in 2002. Since then, the incidence of IP has significantly decreased. The aim of this study was to elucidate the prophylactic effect of MCZ for the treatment of neonatal IP, and to establish a new prophylactic concept for this disease. METHODS: In in vivo experiments, the effects of MCZ were examined histopathologically using a mouse model of intestinal ischemia...
October 2016: Pediatric Surgery International
K Kadono, Y Uchida, H Hirao, T Miyauchi, T Watanabe, S Ueda, A Kanazawa, A Mori, H Okajima, H Terajima, S Uemoto
Liver ischemia-reperfusion injury (IRI) is an important problem in liver transplantation. Thrombomodulin (TM), an effective drug for disseminated intravascular coagulation, is also known to exhibit anti-inflammatory effect through binding to high mobility box-1 protein (HMGB-1) known as a pro-inflammatory mediator. Here we examined the effect of recombinant human TM (rTM) on partial warm hepatic IRI model in WT and toll-like receptor-4 (TLR-4) KO mice focusing on HMGB-1/TLR-4 axis. As in vitro experiments, peritoneal macrophages were stimulated with recombinant HMGB-1 protein...
July 28, 2016: American Journal of Transplantation
Keisuke Kakisaka, Kojiro Kataoka, Yuji Suzuki, Yohei Okada, Yuichi Yoshida, Hidekatsu Kuroda, Yasuhiro Takikawa
BACKGROUND & AIMS: The aim of this study was to investigate the clinical characteristics and pathophysiology of drug-induced liver injury (DILI) - acute liver failure (ALF). METHODS: The patients with acute liver injury (ALI) including ALF from 2009 to 2014 were analyzed. The hepatic encephalopathy (HE) development rate was compared with the findings from a national survey in Japan. The serum cytokines levels and the findings of a liver function test were evaluated in the DILI patients...
October 2016: Cytokine
Christopher A Adin, Zachary C VanGundy, Tracey L Papenfuss, Feng Xu, Mostafa Ghanem, Jonathan Lakey, Gregg A Hadley
Bilirubin has been recognized as a powerful cytoprotectant when used at physiologic doses and was recently shown to have immunomodulatory effects in islet allograft transplantation, conveying donor specific tolerance in a murine model. We hypothesized that bilirubin, an antioxidant, acts to suppress the innate immune response to islet allografts through two mechanisms: 1) by suppressing graft release of damage associated molecular patterns (DAMPs) and inflammatory cytokines, and 2) by producing a tolerogenic phenotype in antigen presenting cells...
July 7, 2016: Cell Transplantation
Dong-Jiao Wang, Ju-Juan Wang, Meng Song, Xin Gao, Li-Min Duan, Tian Tian, Hong-Xia Qiu
OBJECTIVE: To investigate the expression levels and clinical significance of serum high mobility group box 1 (HMGB-1) in patients with secondary hemophagocytic lymphohistiocytosis (sHLH). METHODS: Serum HMGB-1 levels were determined by using enzyme linked immunosorbent assays (ELISA) in 51 sHLH patients and 15 healthy contrlols. Other laboratory data, including soluble interleukin-2 receptor (sCD25), white blood cells (WBC), hemoglobin (Hb), platelet (Plt), fibrinogen (FIB), lactate dehydrogenase (LDH), triglyceride (TG), alanine transaminase (ALT), aspartate aminotransferase (AST), serum ferritin (SF), C reactive protein (CRP), and blood sedimentation rate (ESR) were also collected...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Hiroaki Ooboshi, Takashi Shichita
Post-ischemic inflammation is re-appraised as an important player in the progression of ischemic stroke. Activation of inflammatory cells via Toll-like receptor 2 (TLR2) and TLR4 is caused by several damage-associated molecular patterns (DAMPs), including high mobility group box-1 (HMGB-1) and heat shock proteins. We have recently found that peroxiredoxin (Prx) is one of the strong DAMPs and activates infiltrating macrophages in brain ischemia. We have also found that interleukin-23 (IL-23) from the activated macrophages stimulates γδT cells which release IL-17, thereby causing the delayed expansion of infarct lesions...
April 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
Xi Ling, Hong Zhang, Xi-qin Yi, Jin-feng Wu
OBJECTIVE: To observe the relatively specific effect of electroacupuncture (EA) of "Xiajuxu" (ST 39, the lower hesea paint of the small intestine), etc. on the level of serum TNF-alpha, lnterleukin-1 P (IL-1 P) and high mobility group protein B 1 (HMGB 1) contents, and duodenum a7 nicotinic acetyicholine receptor (nAchR) expression in duodenal ulcer rats, so as to explore its mechanisms underlying improving duodenal ulcer. METHODS: Sixty SD rats were randomly divided into 6 groups: normal control, model, Xiajuxu (ST 39), Zusanli (ST 36), Shangjuxu (ST 37) and Yanglingquan (GB 34)...
April 2016: Zhen Ci Yan Jiu, Acupuncture Research
Taku Omura, Shigeki Kushimoto, Satoshi Yamanouchi, Daisuke Kudo, Noriko Miyagawa
BACKGROUND: Alarmins, including high-mobility group box 1 (HMGB-1), can be released from damaged tissues and activated cells as inflammatory mediators. We aimed to evaluate HMGB-1 and mitochondrial DNA dynamics and estimate the prognostic value for neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest. METHODS: We evaluated the dynamics of HMGB-1, mitochondrial DNA, and other variables in patients with return of spontaneous circulation after out-of-hospital cardiac arrest...
2016: Journal of Intensive Care
Wenhai Zhou, Jing Wang, Zhifeng Li, Jianguo Li, Ming Sang
Inflammatory cytokines belonging to high mobility group box (HMGB)1 play a key role in sepsis through yet unknown mechanisms. The inflammatory response is modulated by microRNAs (miRNAs or miRs) at multiple levels and is poorly understood. In this study, the regulation of HMGB1 by miRNAs was evaluated using 3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21) to activate the cholinergic anti-inflammatory pathway (CAP) and decrease HMGB1 expression in RAW264.7 cells. Microarray-based miRNA expression profiling of RAW264...
July 2016: International Journal of Molecular Medicine
Nicolas Riteau, Aurélie Gombault, Isabelle Couillin
The evaluation of the inflammasome activation usually addresses the presence of extracellular IL-1β and IL-18 or the secretion of danger signal proteins such as HMGB-1 through their quantification using an enzyme-linked immunosorbent assay (ELISA). The ELISA is a routine laboratory technique that uses antibodies and colorimetric changes to identify a substance of interest. ELISA uses a solid-phase enzyme immunoassay to detect the presence of a substance, usually an antigen, in a liquid or wet sample. Using 96 well plates, the ELISA technique enables to quantify the concentration of a single cytokine in multiple samples...
2016: Methods in Molecular Biology
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