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https://www.readbyqxmd.com/read/29129476/pyroptosis-and-its-relationship-to-atherosclerosis
#1
REVIEW
Yuan-Jun Xu, Lei Zheng, Yan-Wei Hu, Qian Wang
Pyroptosis is a pro-inflammatory form of regulated cell death and is dependent on the enzymatic activity of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific proteases (caspases). Pyroptosis is morphologically, mechanistically, and pathophysiologically distinct from other forms of cell death, including apoptosis and necrosis. Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1...
November 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29115455/dioscin-inhibits-ischemic-stroke%C3%A2-induced-inflammation-through-inhibition-of-the-tlr4-myd88-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#2
Shilin Zhu, Siyuan Tang, Feng Su
Diosgenin, as an essential natural steroidal saponin, can be extracted from numerous sources, primarily from fenugreek. It is an important raw material for the synthesis of steroid hormone drugs. It exhibits antitumor, anti‑inflammatory, antioxidation and several other significant pharmacologic actions, and is of high pharmaceutical value. In the present study, the activities and underlying mechanisms of dioscin in the inhibition of ischemic stroke in rats were investigated. Inflammatory responses wer analyzed using ELISA kits and caspase‑3 and caspase‑9 activity was analyzed using Caspase‑3 and caspase‑9 activity kits...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29094325/the-expression-of-matrix-metalloproteinases-and-their-inhibitors-in-corneal-fibroblasts-by-alarmins-from-necrotic-corneal-epithelial-cells
#3
Akira Iwatake, Akira Murakami, Nobuyuki Ebihara
PURPOSE: Sterile ulceration is frequently observed in the cornea following persistent corneal epithelial damage. We examined the effect of alarmins released by necrotic corneal epithelial cells (HCE) on the production of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by corneal fibroblasts. METHODS: IL-1α and high-mobility group box 1 protein (HMGB1) released into the supernatant derived from necrotic HCE cells were measured with enzyme-linked immunosorbent assay (ELISA)...
November 1, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29065965/identification-of-specifically-activated-angiogenic-molecules-in-hmgb-1-induced-angiogenesis
#4
Won Kyu Kim, Yujin Kwon, Minhee Park, Seongju Yun, Ja-Young Kwon, Hoguen Kim
High-mobility group box-1 (HMGB-1) is expressed in almost all cells, and its dysregulated expression correlates with inflammatory diseases, ischemia, and cancer. Some of these conditions accompany HMGB-1-mediated abnormal angiogenesis. Thus far, the mechanism of HMGB-1-induced angiogenesis remains largely unknown. In this study, we performed time-dependent DNA microarray analysis of endothelial cells (ECs) after HMGB-1 or VEGF treatment. The pathway analysis of each gene set upregulated by HMGB-1 or VEGF showed that most HMGB-1-induced angiogenic pathways were also activated by VEGF, although the activation time and gene sets belonging to the pathways differed...
October 25, 2017: BMB Reports
https://www.readbyqxmd.com/read/29017437/high-expression-of-high-mobility-group-box-1-in-menstrual-blood-implications-for-endometriosis
#5
Keiko Shimizu, Yasuhiko Kamada, Ai Sakamoto, Miwa Matsuda, Mikiya Nakatsuka, Yuji Hiramatsu
Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28987932/ethyl-pyruvate-ameliorates-inflammatory-arthritis-in-mice
#6
Seung Min Jung, Jaeseon Lee, Seung Ye Baek, Juhyun Lee, Se Gwang Jang, Seung-Min Hong, Jin-Sil Park, Mi-La Cho, Sung-Hwan Park, Seung-Ki Kwok
OBJECTIVES: Ethyl pyruvate (EP) is the ethyl ester of pyruvate and has antioxidative and anti-inflammatory effects. This study aimed to evaluate the therapeutic effect of EP in inflammatory arthritis and to identify the underlying mechanisms. METHODS: Mice with collagen-induced arthritis (CIA) were treated with the vehicle control or EP at 20mg/kg, and clinical and histological analyses were performed on the animals. The differentiation of murine CD4+ T cells into T helper 17 (Th17) cells in the presence of EP was investigated in vitro...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28966323/porphyromonas-gingivalis-elevated-high-mobility-group-box-1-levels-after-myocardial-infarction-in-mice
#7
Rungtiwa Srisuwantha, Yuka Shiheido, Norio Aoyama, Hiroki Sato, Keitetsu Kure, Narongsak Laosrisin, Yuichi Izumi, Jun-Ichi Suzuki
High mobility group box 1 (HMGB1) is a nuclear protein released from necrotic cells, inducing inflammatory responses. Epidemiological studies suggested a possible association between periodontitis and cardiovascular diseases (CVDs). Due to tissue damage and necrosis of cardiac cells following myocardial infarction (MI), HMGB1 is released, activating an inflammatory reaction. However, it remains unclear whether periodontitis is also involved in myocardial damage. The purpose of this study was to determine the effect of the periodontal pathogen Porphyromonas gingivalis (P...
October 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28962177/high-mobility-group-box-1-in-diabetic-nephropathy
#8
Haitao Shi, Yingqi Che, Lin Bai, Jinling Zhang, Jingxu Fan, Huiling Mao
Type 2 diabetes (T2D) is a complex disorder caused by the combined effects of genetic inheritance and environmental factors. The abnormal secretion of albumin via urine is the characteristic feature of a diabetic nephropathy (DN) patient. Moreover, the detection of this observable characteristic feature of DN is quite late. As a result the time, at which DN is observable, large extent of kidney damage has already occurred. Thus, this late observation significantly decreases the chances of efficient management of DN and associated outcomes...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28952834/silibinin-effect-on-fas-fasl-hmgb1-and-cd45-expressions-in-a-rat-model-subjected-to-liver-ischemia-reperfusion-injury
#9
Alexandra K Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E Simopoulos
PURPOSE: We investigated the hepatoprotective effect of Silibinin (SLB) to ischemia-reperfusion (I/R) rat model, by evaluating the histological expression of the tissue markers Fas/FasL, HMGB-1 and CD45, and SLB pharmacokinetics. METHODS: Seventy-three Wistar-type male rats were randomized in 11 groups: Sham control group (open-close laparotomy); four I/R control groups (laparotomy, 45 min vascular occlusion, reperfusion, euthanasia after 60, 120, 180, and 240 min); four SLB (Si) groups (laparotomy, 45 min vascular occlusion, IV administration of SLB, reperfusion, euthanasia after 60, 120, 180, and 240 min); two SLB pharmacokinetics (PK) groups (IV administration of SLB, euthanasia after 45 and 240 min)...
September 27, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28885495/isoglycyrrhizinate-magnesium-enhances-hepatoprotective-effect-of-fk506-on-ischemia-reperfusion-injury-through-hmgb1-inhibition-in-a-rat-model-of-liver-transplantation
#10
Zhang Weichen, Li Feibo, Ye Yufu, Liu Yuanxing, Yu Songfeng, Cen Chao, Chen Xuliang, Zhou Lin, Tang Xiaofeng, Yu Jun, Zheng Shusen
BACKGROUND: Ischemia-reperfusion injury (IRI) after liver transplantation impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether Iso alone have protective effect after IRI in a rat model of liver transplantataion. We also aimed to study whether Iso could enhance the hepatoprotective effect of FK506 (tacrolimus) and underlying mechanism. METHODS: Rats after liver transplantation were treated with different concentration of FK506 with or without, Iso or lower-dose FK506 plus Iso...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28885322/is-serum-high-mobility-group-box-1-hmgb-1-level-correlated-with-liver-fibrosis-in-chronic-hepatitis-b
#11
Ahmet Cagkan Inkaya, Nazlim Aktug Demir, Servet Kolgelier, Sua Sumer, Lutfi Saltuk Demir, Onur Ural, Fatma Seher Pehlivan, Mahmure Aslan, Abdullah Arpaci
BACKGROUND: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis. METHOD: This cross-sectional case-control study included 189 chronic hepatitis B (CHB) patients and 51 healthy controls. All patients underwent liver biopsy and modified Knodell scoring system used to determine the fibrosis level in CHB patients...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28876118/-effects-of-complement-c5a-inhibitor-therapy-in-animal-models-of-non-occlusive-mesenteric-ischemia
#12
Miklós Nógrády, Gabriella Varga, Szilárd Szűcs, József Kaszaki, Mihály Boros, Dániel Érces
INTRODUCTION: Non-occlusive mesenteric ischemia (NOMI) develops without anatomical causes. Early diagnosis is challenging and treatments are of questionable effectiveness. We investigated the role of complement activation in the pathophysiology of NOMI in animal models through the inhibition of complement C5a. MATERIALS AND METHODS: 60-min partial aortic occlusion (PAO; abdominal aorta, proximal to celiac trunk; mean arterial pressure: 30-40 mmHg) was established in Sprague-Dawley rats (n = 28) and 60-min cardiac tamponade in minipigs (n = 19; mean arterial pressure: 40-50 mmHg) to observe short- and long-term circulatory and inflammatory consequences of NOMI...
September 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28843664/circulating-syndecan-1-predicts-the-development-of-disseminated-intravascular-coagulation-in-patients-with-sepsis
#13
Mitsunori Ikeda, Hisatake Matsumoto, Hiroshi Ogura, Tomoya Hirose, Kentaro Shimizu, Kouji Yamamoto, Ikuro Maruyama, Takeshi Shimazu
PURPOSE: One of the pathophysiological processes in sepsis is endothelial dysfunction, which leads to disseminated intravascular coagulation (DIC). Syndecan-1 is a major structural component of the endothelium and plays a key role in endothelial function. The purpose of this study was to assess the value of syndecan-1 as a predictive marker for DIC in sepsis. METHODS: We performed a prospective observational study of patients with sepsis from February 2014 to July 2015...
July 28, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28821136/discovery-of-enzymatically-depolymerized-heparins-capable-of-treating-bleomycin-induced-pulmonary-injury-and-fibrosis-in-mice
#14
Yishu Yan, Shanshan Du, Yang Ji, Nan Su, Yi Wang, Xiang Mei, Wenming Zhu, Dong He, Yuan Lu, Chong Zhang, Xin-Hui Xing
Heparin has recently been shown to slow down idiopathic pulmonary fibrosis (IPF) process and improve survival of patients in some cases. To improve the anti-IPF function while minimizing their side effects, we developed heparin libraries with different structures depolymerized by single or combined heparinases, and systematically screened the efficacy of the different heparins for treatment of Bleomycin-induced pulmonary injury and fibrosis using mice model. Then we characterized the structural properties of the components capable of treating pulmonary injury and fibrosis by use of chip-based amide hydrophilic interaction chromatography (HILIC)-fourier transform (FT)-ESI-MS, polyacrylamide gel electrophoresis (PAGE), and high performance liquid chromatography (HPLC)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28804542/significant-association-of-trem-1-with-hmgb1-tlrs-and-rage-in-the-pathogenesis-of-insulin-resistance-in-obese-diabetic-populations
#15
Saravanan Subramanian, Pradeep K Pallati, Poonam Sharma, Devendra K Agrawal, Kalyana C Nandipati
Activated cell surface and intracellular receptors lead to insulin resistance in obesity. Among these receptors, triggering receptors expressed on myeloid cells (TREM)-1, toll like receptors (TLRs), and receptors for advanced glycation end products (RAGE) play a significant role in the induction of inflammatory response in innate immunity. TREM-1 potentially amplifies TLRs and RAGE synergistically with DNA-binding high-mobility group box 1 (HMGB-1). The objective of the study was to analyze the association between TREM-1/DAP12 and HMGB-1, RAGE and TLRs in obesity-induced insulin resistance...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28789654/serum-high-mobility-group-box-1-and-osteoprotegerin-levels-are-associated-with-peripheral-arterial-disease-and-critical-limb-ischemia-in-type-2-diabetic-subjects
#16
Silvia Giovannini, Giovanni Tinelli, Federico Biscetti, Giuseppe Straface, Flavia Angelini, Dario Pitocco, Luciana Mucci, Raffaele Landolfi, Andrea Flex
BACKGROUND: High mobility group box-1 (HMGB-1) is a nuclear protein also acting as inflammatory mediator, whilst osteoprotegerin (OPG), member of tumor necrosis factor receptor superfamily, is indicated as marker of vascular calcification. Peripheral artery disease (PAD) and type 2 diabetes (T2D) are clinical conditions characterized by elevated serum inflammatory markers and vascular calcification enhancement. The aim of this study was to investigate the potential role of HMGB-1, OPG and several inflammatory mediators such as C-reactive protein (HsCRP), tumor necrosis factor-alpha and interleukin-6 (IL-6) on the presence and severity of peripheral artery disease in patients with T2D...
August 8, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28771195/scar-prevention-and-enhanced-wound-healing-induced-by-polydeoxyribonucleotide-in-a-rat-incisional-wound-healing-model
#17
Woonhyeok Jeong, Chae Eun Yang, Tai Suk Roh, Jun Hyung Kim, Ju Hee Lee, Won Jai Lee
High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was administered via intraperitoneal injection for three (PDRN-3 group, n = 8) or seven (PDRN-7 group, n = 8) days, and HMGB-1 was administered via intradermal injection in addition to PDRN treatment for three days (PDRN-3+HMGB-1 group; n = 6)...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28741799/multicenter-study-for-brain-body-hypothermia-for-hypoxic-ischemic-encephalopathy-changes-in-hmgb-1
#18
Toshihiko Nakamura, Hideomi Asanuma, Satoshi Kusuda, Ken Imai, Shigeharu Hosono, Ryota Kato, Satoshi Suzuki, Kyoko Yokoi, Minoru Kokubo, Shingo Yamada, Takashi Kamohara
BACKGROUND: We measured changes in the blood level of high-mobility group box-1 (HMGB-1) at 24 h intervals in neonates treated with brain/body hypothermia (body hypothermia therapy: BHT) for hypoxic-ischemic encephalopathy (HIE), to evaluate the usefulness of HMGB-1 level for determining outcomes. METHODS: We studied 15 neonates with HIE who underwent BHT (BHT (+) group) and six neonates with HIE who did not (BHT (-) group). We recorded HMGB-1 changes at 24 h intervals, creatinine phosphokinase, and the resistance index of the anterior cerebral artery...
October 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28694659/induction-of-chronic-cholestasis-without-liver-cirrhosis-creation-of-an-animal-model
#19
Felix Dondorf, René Fahrner, Michael Ardelt, Eleonora Patsenker, Felix Stickel, Uta Dahmen, Utz Settmacher, Falk Rauchfuß
AIM: To analyze time intervals of inflammation and regeneration in a cholestatic rat liver model. METHODS: In 36 Lewis rats, divided into six groups of 6 animals (postoperative observation periods: 1, 2, 3, 4, 6, 8 wk), the main bile duct was ligated with two ligatures and observed for the periods mentioned above. For laboratory evaluation, cholestasis parameters (bilirubin, γ-GT), liver cell parameters (ASAT, ALAT) and liver synthesis parameters (quick, albumin) were determined...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28689646/higher-m30-and-high-mobility-group-box-1-protein-levels-in-ex-vivo-lung-perfusate-are-associated-with-primary-graft-dysfunction-after-human-lung-transplantation
#20
Kohei Hashimoto, Marcelo Cypel, Stephen Juvet, Tomohito Saito, Ricardo Zamel, Tiago N Machuca, Michael Hsin, Hyunhee Kim, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ex vivo lung perfusion (EVLP) enables assessment of marginal donor lungs for transplantation, with similar clinical outcomes to conventional lung transplantation. We investigated whether cell death-related proteins in the EVLP perfusate could predict primary graft dysfunction (PGD) after transplantation. METHODS: M30 (indicating epithelial apoptosis), M65 (indicating total epithelial cell death), and high mobility group box 1 (HMGB-1, related to cell death and inflammation) protein levels in EVLP perfusate were measured by enzyme-linked immunosorbent assay and correlated with clinical outcomes...
June 21, 2017: Journal of Heart and Lung Transplantation
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