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https://www.readbyqxmd.com/read/29754505/1-formula-see-text-2-formula-see-text-3-formula-see-text-4-formula-see-text-6-penta-o-galloyl-%C3%AE-d-glucose-from-galla-rhois-ameliorates-renal-tubular-injury-and-microvascular-inflammation-in-acute-kidney-injury-rats
#1
Ji Hun Park, Min Chol Kho, Hyun Cheol Oh, Youn Chul Kim, Jung Joo Yoon, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
Renal ischemia-reperfusion injury (IRI), an important cause of acute kidney injury (AKI), causes increased renal tubular injury and microvascular inflammation. 1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-penta-O-galloyl-[Formula: see text]-D-glucose (PGG) from Galla rhois has anticancer, anti-oxidation and angiogenesis effects. We examined protective effects of PGG on IRI-induced acute AKI. Clamping both renal arteries for 45[Formula: see text]min induced isechemia and then reperfusion...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29750887/the-effects-of-acute-hypoxia-on-tissue-oxygenation-and-circulating-alarmins-in-healthy-adults
#2
C J Boos, C M Lamb, M Midwinter, A Mellor, D R Woods, M Howley, T Stansfield, M Foster, J P O'hara
The binding of high-mobility group box-1 (HMGB-1) to the membrane receptor for advanced glycation end-products (mRAGE) is a key early mediator of non-infectious inflammation and its triggers include ischaemia/hypoxia. The effects of acute hypoxia on soluble RAGE (sRAGE) are unknown. Fourteen healthy adults (50% women; 26.6+/-3.8 years) were assessed at baseline normoxia (T0), followed by four time-points (T90, 95, 100 and 180 minutes) over three hours of continuous normobaric hypoxia (NH, 4450m equivalent) and again 60 minutes after return to normoxia (T240)...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29745087/high-mobility-group-box-1-hmgb1-expression-in-gastric-adenocarcinomas
#3
Dinc Suren, Ahmet Arda Gokay, Alper Sayiner
PURPOSE: High mobility group box 1 (HMGB1), the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. The purpose of this study was to investigate the expression of HMGB-1 in gastric adenocarcinoma (GC) and to evaluate its diagnostic and prognostic value. METHODS: This study included 85 cases histopathologically diagnosed with GC...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29701897/sirt1-attenuates-murine-allergic-rhinitis-by-downregulated-hmgb-1-tlr4-pathway
#4
Yong Yuan, Qin-Song Liu, Jing Zhao, Hua-Ping Tang, Jie Sun
Conventional allergic rhinitis (AR) treatments have limitations due to the lack of safety and complete cure strategy. We evaluated the effects of Silent information regulator 1 (SIRT1), a multifunctional molecule involved in a variety of inflammatory pathways, on murine AR model. Ovalbumin (OVA)-induced murine model was constructed, and recombinant SIRT1 was administered into the nostril continuously. The expression of SIRT1 was measured at mRNA and protein levels, and the allergic symptoms were evaluated. Protein levels of OVA-specific IgE, leukotriene C4 (LTC4), eosinophil cation protein (ECP), Prostaglandin D2 (PGD2), as well as different inflammatory cytokine mediators in the serum and nasal lavage fluid (NLF) were assessed by ELISA...
April 27, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#5
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668774/effect-of-ozone-oxidative-preconditioning-on-inflammation-and-oxidative-stress-injury-in-rat-model-of-renal-transplantation
#6
Zhishun Wang, Qi Han, Yong-Lian Guo, Xiu-Heng Liu, Tao Qiu
PURPOSE: To investigate the effect of ozone oxidative preconditioning (OzoneOP) on inflammation and oxidative stress injury in rat model of renal transplantation. METHODS: Thirty six male Sprague Dawley (SD) rats were randomly divided into three groups. Sham group: rats were treated with opening and closing abdomen. Kidney transplantation group (KT group): SD rat received the donor's left kidney derived from another SD rat. Ozone oxidative preconditioning and kidney transplantation (OOP+KT group): donor SD rats received OzoneOP treatments by transrectal insufflations before kidney transplantation...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29630133/ketamine-alleviates-lps-induced-lung-injury-by-inhibiting-hmgb1-rage-level
#7
Y Zhang, M Zhang, C-Y Wang, A Shen
OBJECTIVE: Inflammatory cytokines secretion is an important reason to promote lung tissue inflammation in acute lung injury (ALI). High mobility group box 1 (HMGB-1) and its receptor for advanced glycation end products (RAGEs) play a role in ALI. Ketamine can significantly alleviate ALI, whereas its specific mechanism has not been fully elucidated. MATERIALS AND METHODS: A total of 60 male Wistar rats were equally randomly divided into three groups, including ALI group which was established by 10 mg/kg LPS femoral vein injection, ketamine group which was constructed by 50 mg/kg ketamine femoral vein injection based on ALI model, and control group...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29588304/inhibitory-mechanisms-of-very-low-dose-rivaroxaban-in-non-st-elevation-myocardial-infarction
#8
Oliver Borst, Patrick Münzer, Nada Alnaggar, Sascha Geue, Roland Tegtmeyer, Dominik Rath, Michal Droppa, Peter Seizer, Stefan Heitmeier, Johan W M Heemskerk, Lisa K Jennings, Robert F Storey, Dominick J Angiolillo, Bianca Rocca, Henri Spronk, Hugo Ten Cate, Meinrad Gawaz, Tobias Geisler
Very low-dose (VLD) factor Xa (FXa) inhibition, in combination with acetylsalicylic acid (ASA) and clopidogrel, is associated with improved outcomes in patients with acute coronary syndrome (ACS) with a tolerable bleeding risk profile. To date, there are no data documenting platelet inhibition and the anticoagulatory effects of VLD FXa inhibition on top of guideline-adherent dual-antiplatelet therapy (DAPT) in patients with ACS. Patients with non-ST-elevation myocardial infarction (NSTEMI) receiving oral DAPT (ASA + clopidogrel, n = 20; or ASA + ticagrelor, n = 20) were prospectively enrolled in a nonrandomized study...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29559369/assessment-of-hmgb-1-concentration-in-tick-borne-encephalitis-and-neuroborreliosis
#9
Anna Moniuszko-Malinowska, Paweł Penza, Piotr Czupryna, Olga Zajkowska, Sławomir Pancewicz, Renata Świerzbińska, Justyna Dunaj, Joanna Zajkowska
BACKGROUND: The aim of this study was to determine the concentration of HMGB-1 (high mobility group box 1) in the serum and cerebrospinal fluid (CSF) of patients suffering from tick-borne encephalitis (TBE) and neuroborreliosis (NB). Focus was placed on HMGB-1 measurement in the CSF or serum in order to establish whether this could help to differentiate between NB and TBE. METHODS: Eighty patients with meningitis and meningoencephalitis were enrolled in the study...
March 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29558743/glycyrrhizin-treatment-facilitates-extinction-of-conditioned-fear-responses-after-a-single-prolonged-stress-exposure-in-rats
#10
Shuhua Lai, Gangwei Wu, Zhixian Jiang
BACKGROUND/AIMS: Impaired fear memory extinction is widely considered a key mechanism of post-traumatic stress disorder (PTSD). Recent studies have suggested that neuroinflammation after a single prolonged stress (SPS) exposure may play a critical role in the impaired fear memory extinction. Studies have shown that high mobility group box chromosomal protein 1 (HMGB-1) is critically involved in neuroinflammation. However, the role of HMGB-1 underlying the development of impairment of fear memory extinction is still not known...
March 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29554649/pioglitazone-confers-neuroprotection-against-ischemia-induced-pyroptosis-due-to-its-inhibitory-effects-on-hmgb-1-rage-and-rac1-ros-pathway-by-activating-ppar-%C3%A9
#11
Pingping Xia, Yundan Pan, Fan Zhang, Na Wang, E Wang, Qulian Guo, Zhi Ye
BACKGROUND/AIMS: Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in the progression of cerebral ischemia-reperfusion injury. However, there has been no study on the application of pioglitazone in treating ischemic stroke through mechanisms involving pyroptosis. METHODS: The cerebral injury was established by middle cerebral artery occlusion (MCAO). in vitro ischemia in primary cultured astrocytes was induced by the oxygen-glucose deprivation (OGD)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29554045/adenosine-lidocaine-and-mg2-alm-resuscitation-fluid-protects-against-experimental-traumatic-brain-injury
#12
Hayley L Letson, Geoffrey P Dobson
BACKGROUND: Currently, no drug therapy prevents secondary injury progression after traumatic brain injury (TBI). Our aim was to investigate the effects of small-volume intravenous adenosine, lidocaine, and Mg (ALM) resuscitation fluid after moderate TBI in a rat fluid-percussion injury model. METHODS: Anesthetized, mechanically ventilated male Sprague-Dawley rats (449 ± 5 g) were randomly assigned to one of four groups: (1) sham (craniotomy without TBI), (2) no-treatment, (3) saline-control, or (4) ALM therapy groups (all n = 16)...
June 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29399172/loss-of-beclin-1-expression-in-ovarian-cancer-a-potential-biomarker-for-predicting-unfavorable-outcomes
#13
Toshiko Minamoto, Kentaro Nakayama, Kohei Nakamura, Hiroshi Katagiri, Razia Sultana, Tomoka Ishibashi, Masako Ishikawa, Hitomi Yamashita, Kaori Sanuki, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Noriyuki Ishikawa, Satoru Kyo
The clinicopathological significance and prognostic value of the expression of proteins associated with autophagy, beclin 1 (BECN1), 1A/1B-light chain 3 (LC3) and high mobility group box-1 protein (HMGB-1), were investigated in patients with ovarian carcinoma, receiving combination chemotherapy with a platinum agent and a taxane. Immunohistochemical staining was performed for autophagy-associated proteins in tumor tissues from 141 patients with ovarian carcinoma. Clinical data were collected retrospectively by reviewing medical charts, and the association between protein expression, clinicopathological features and survival was investigated...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29389558/anti-inflammatory-effect-of-cinnamaldehyde-and-linalool-from-the-leaf-essential-oil-of-cinnamomum-osmophloeum-kanehira-in-endotoxin-induced-mice
#14
Shih-Chieh Lee, Shih-Yun Wang, Chien-Chun Li, Cheng-Tzu Liu
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated the chemical composition and anti-inflammatory effect of leaf essential oil of Cinnamomum osmophloeum Kanehira of linalool chemotype in streptozotocin-induced diabetic rats and on endotoxin-injected mice. The aim of the present study is to evaluate whether cinnamaldehyde and linalool the active anti-inflammatory compounds in leaf essential oil of Cinnamomum osmophloeum Kanehira...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29370247/broad-adsorption-of-sepsis-related-pamp-and-damp-molecules-mycotoxins-and-cytokines-from-whole-blood-using-cytosorb%C3%A2-sorbent-porous-polymer-beads
#15
Maryann C Gruda, Karl-Gustav Ruggeberg, Pamela O'Sullivan, Tamaz Guliashvili, Andrew R Scheirer, Thomas D Golobish, Vincent J Capponi, Phillip P Chan
OBJECTIVE: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In sepsis and septic shock, pathogen-associated molecular pattern molecules (PAMPS), such as bacterial exotoxins, cause direct cellular damage and/or trigger an immune response in the host often leading to excessive cytokine production, a maladaptive systemic inflammatory response syndrome response (SIRS), and tissue damage that releases DAMPs, such as activated complement and HMGB-1, into the bloodstream causing further organ injury...
2018: PloS One
https://www.readbyqxmd.com/read/29324261/platelet-toll-like-receptor-and-its-ligand-hmgb-1-expression-is-increased-in-the-left-atrium-of-atrial-fibrillation-patients
#16
Kadri Murat Gurses, Duygu Kocyigit, Muhammed Ulvi Yalcin, Hande Canpinar, Banu Evranos, Ugur Canpolat, Hikmet Yorgun, Levent Sahiner, Dicle Guc, Kudret Aytemir
BACKGROUND: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study. METHODS: Persistent and paroxysmal AF patients who underwent cryoballoon-based AF ablation between March 2015 and July 2016 were included as the patient group...
March 2018: Cytokine
https://www.readbyqxmd.com/read/29260012/time-courses-of-plasma-il-6-and-hmgb-1-reflect-initial-severity-of-clinical-presentation-but-do-not-predict-poor-neurologic-outcome-following-subarachnoid-hemorrhage
#17
Heikki Kiiski, Jaakko Långsjö, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hämäläinen, Eeva Moilanen, Juha Öhman, Jukka Peltola
Objective: Patients with aneurysmal subarachnoid hemorrhage (aSAH) experience high mortality and morbidity. Neuroinflammation causes brain damage expansion after aSAH. Due to the complexity of the inflammatory response multiple biomarkers are needed to evaluate its' progression. We studied inflammatory process after aSAH by measuring two inflammatory biomarkers, interleukin-6 (IL-6) and high-mobility group box 1 (HMGB1) at simultaneous time-points after aSAH. Methods: In this prospective population-based study, IL-6 and HMGB1 were measured in aSAH patients (n = 47) for up to five days...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29249869/short-term-postoperative-cognitive-dysfunction-and-inflammatory-response-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-pilot-study
#18
Hui Yu, Rui Dong, Yayuan Lu, Xi Yang, Chang Chen, Zongze Zhang, Mian Peng
Objectives: To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Design: A prospective cohort study. Setting: University medical centre. Participants: Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants. Measurements: The inflammatory marker levels in plasma and cognitive function were measured...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29248428/irradiation-enhances-abscopal-anti-tumor-effects-of-antigen-specific-immunotherapy-through-regulating-tumor-microenvironment
#19
Ming-Cheng Chang, Yu-Li Chen, Han-Wei Lin, Ying-Cheng Chiang, Chi-Fang Chang, Shu-Feng Hsieh, Chi-An Chen, Wei-Zen Sun, Wen-Fang Cheng
Ionizing radiation therapy is a well-established method of eradicating locally advanced tumors. Here, we examined whether local RT enhanced the potency of an antigen-specific DNA vaccine, and we investigated the possible underlying mechanism. Using the HPV16 E6/E7+ syngeneic TC-1 tumor, we evaluated the combination of CTGF/E7 vaccination with local irradiation with regard to synergistic antigen-specific immunity and anti-tumor effects. Tumor-bearing mice treated with local RT (6 Gy twice weekly) and CTGF/E7 DNA vaccination exhibited dramatically increased numbers of E7-specific CD8+ cytotoxic T cell precursors, higher titers of anti-E7 Abs, and significantly reduced tumor size...
February 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29201182/the-efficacy-of-gastrodin-in-combination-with-folate-and-vitamin-b12-on-patients-with-epilepsy-after-stroke-and-its-effect-on-hmgb-1-il-2-and-il-6-serum-levels
#20
Hao Zhou, Nuan Wang, Lei Xu, Hongli Huang, Chunyu Yu
This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly divided into control and observation groups (n=46 each) using computer software. Patients in the control group were administered only regular antiepileptic drugs, whereas observation group patients also received a combination of gastrodin, FOL and V-B12...
November 2017: Experimental and Therapeutic Medicine
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