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Ulla Forsgren-Brusk, Birgitta Yhlen, Marie Blomqvist, Peter Larsson
PURPOSE: The purpose of this study was to evaluate a pragmatic laboratory method to provide a technique for developing incontinence products better able to reduce malodor when used in the clinical setting. METHODS: Bacterial growth and bacterially formed ammonia in disposable absorbent incontinence products was measured by adding synthetic urine inoculated with bacteria to test samples cut from the crotch area of the product. The inhibitory effect's of low pH (4...
October 5, 2016: Journal of Wound, Ostomy, and Continence Nursing
Ha Ryong Kim, Da Young Shin, Kyu Hyuck Chung
Polyhexamethylene biguanide (PHMB) is a member of the polymeric guanidine family, which is used as a biocide and preservative in industrial, medicinal, and consumer products. Some studies reported that polyhexamethylene guanidine phosphate, which is also a member of the guanidine family, induced severe inflammation and fibrosis in the lungs. However, limited studies have evaluated the pulmonary toxicity of PHMB associated with inflammatory responses. The aim of this study was to elucidate the inflammatory responses and its mechanisms induced by PHMB in lung cells...
October 13, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Karim Saleh, Andreas Sonesson, Kerstin Persson, Kristian Riesbeck, Artur Schmidtchen
BACKGROUND: Polyhexamethylene biguanide (PHMB)-based antiseptic solutions can reduce bacterial loads in different clinical settings and are believed to lower risk of infections. OBJECTIVE: We sought to assess the efficacy of a PHMB-based solution in lowering bacterial loads of full-thickness skin grafting wounds and the risk of surgical site infections (SSIs). METHODS: In this double-blinded clinical trial, 40 patients planned for facial full-thickness skin grafting were randomized 1:1 to receive tie-over dressings soaked with either PHMB-based solution or sterile water...
September 27, 2016: Journal of the American Academy of Dermatology
Eliot To, Rebecca Dyck, Stephanie Gerber, Shauna Kadavil, Kevin Y Woo
INTRODUCTION: This is the first systematic review to explore the evidence on PHMB and determine how effective this topical agent is for the treatment of chronic wounds. MATERIALS AND METHODS: PubMed, Ovid MEDLINE, CINAHL, Embase, the Cochrane library, and Scopus were searched for relevant articles published from 1946 to February 3, 2014, with no restrictions on publication status. ProQuest was searched for relevant dissertations, editorials, and conference abstracts...
September 10, 2016: Surgical Technology International
Joseph M Yabes, Brian K White, Clinton K Murray, Carlos J Sanchez, Katrin Mende, Miriam L Beckius, Wendy C Zera, Joseph C Wenke, Kevin S Akers
Soft-tissue invasive fungal infections are increasingly recognized as significant entities directly contributing to morbidity and mortality. They complicate clinical care, requiring aggressive surgical debridement and systemic antifungal therapy. To evaluate new topical approaches to therapy, we examined the antifungal activity and cytotoxicity of Manuka Honey (MH) and polyhexamethylene biguanide (PHMB). The activities of multiple concentrations of MH (40%, 60%, 80%) and PHMB (0.01%, 0.04%, 0.1%) against 13 clinical mould isolates were evaluated using a time-kill assay between 5 min and 24 h...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Manal M Gabriel, Cindy McAnally, John Bartell
OBJECTIVE: The aim of this study was to use antimicrobial efficacy endpoint methodology to determine compatibility of multipurpose disinfecting solutions (MPSs), lens cases, and hydrogel lenses for disinfection (AEEMC) against International Organization for Standardization (ISO)-specified microorganisms and clinical ocular isolates of Stenotrophomonas maltophilia. METHODS: Six MPSs (PQ/Aldox 1, 2, and 3; PQ/Alexidine; PQ/PHMB; and PHMB) were challenged against ISO-specified microorganisms and S...
September 2, 2016: Eye & Contact Lens
Mahesh K Bandara, Simin Masoudi, Hua Zhu, Rani Bandara, Mark D P Willcox
PURPOSE: To investigate the ability of protamine, alone or in combination with other antimicrobial agents, to kill bacteria and fungi associated with contact lens-related keratitis. METHODS: The International Organization for Standardization 14729:2001 procedure was used to test the antimicrobial activity of solutions of protamine (23-228 μM) with and without polyhexamethylene biguanide (PHMB) and ethylenediamine tetra-acetic acid (EDTA). The recommended ISO panel of microbes along with six clinical isolates was tested...
August 17, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Mary Tan, Siti Zubaidah Mordiffi, Dora Lang
The objective of this review is to review and synthesize evidence on the effectiveness of polyhexamethylene biguanide (PHMB) impregnated dressing in wound treatment for patients with chronic or acute wounds, compared with standard dressings or any other antimicrobial dressings.Specifically the questions for this review are.
July 2016: JBI Database of Systematic Reviews and Implementation Reports
Isaac J Asiedu-Gyekye, Abdulai Seidu Mahmood, Charles Awortwe, Alexander K Nyarko
Polyhexamethylene biguanide (PHMB) is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. There are regulatory concerns with regard to its safety in humans for water treatment. We decided to assess the safety of this chemical in Sprague-Dawley rats. PHMB was administered in a single dose by gavage via a stomach tube as per the manufacturer's instruction within a dose range of 2 mg/kg to 40 mg/kg...
December 2015: Interdisciplinary Toxicology
Yong Zhang, Jian Bao, Xin-Xian Deng, Wan He, Jia-Jun Fan, Fa-Qin Jiang, Lei Fu
A series of novel 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives were designed, synthesized and evaluated for their in vitro inhibitory activities against Staphylococcus aureus Sortase A with known Sortase A inhibitor pHMB as positive compound (IC50=130μM). Most compounds exhibited excellent inhibitory activity (IC50=19.8-184.2μM). Structure-activity relationship studies demonstrated that substitution at 7-position and 2-position of benzoxazole had great influence on the activities. Specifically, the substituent at 7-position is indispensable for inhibitory activity...
August 15, 2016: Bioorganic & Medicinal Chemistry Letters
Nina Murphy
Zorflex is a new type of antimicrobial dressing composed of 100% activated carbon cloth. It attracts and binds bacteria to its surface, enabling them to be safely removed at dressing change. It has no reported toxic effects and can be used on either a short-or long-term basis. This article describes 4 case studies in which patients with recalcitrant chronic venous leg ulcers that were prone to recurrent infection were treated with the activated carbon cloth dressing. All of the wounds had failed to respond to antimicrobial dressings containing silver, iodine or polyhexamethylene biguanide (PHMB), and were heavily exuding and painful...
June 23, 2016: British Journal of Nursing: BJN
Julian-Dario Rembe, Carolin Fromm-Dornieden, Nadine Schäfer, Julia K Böhm, Ewa K Stuermer
In this study, polyaminopropyl biguanide (PAPB) was compared to the molecularly closely related polyhexamethylene biguanide (PHMB) with respect to chemical relationship, antiseptic efficacy and cytotoxicity in vitro. Cytotoxicity for human keratinocytes (HaCaTs) and murine fibroblasts (L929) was determined according to ISO EN 10993-5 for both substances. Antimicrobial efficacy tests were performed via determination of the MBC, quantitative suspension method for substances and investigation of two PAPB- or PHMB-containing dressings against Staphyloccoccus aureus, Escherichia coli and Pseudomonas aeruginosa, according to international standards...
August 2016: Journal of Medical Microbiology
Patcharin Tep-areenan, Phongphat Wetchasit, Pattara Sawasdee
OBJECTIVE: To investigate the beneficial effects of Anaxagorea luzonensis (AL) extract on homocysteine thiolactone (HTL)-induced impairment of endothelium-dependent relaxation in rat aortic rings. The mechanisms involved in the effects of AL on endothelial dysfunctions by HTL are also examined. MATERIAL AND METHOD: Aortic rings from male Wistar rats were co-incubated for 90 minutes with L-arginine (3 mM), a precursor of nitric oxide (NO); superoxide dismutase (SOD, 200 U/mL), a scavenger of superoxide anion; indomethacin (10 µM), a cyclooxygenase (COX) inhibitor; SC560 (10 µM), a COX-1 inhibitor; NS398 (10 µM), a COX-2 inhibitor; or SQ29548 (1 µM), a thromboxane A₂ receptor antagonist in the presence of HTL (1 mM)...
November 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Carolina Elsztein, Rita de Cássia Pereira de Lima, Will de Barros Pita, Marcos Antonio de Morais
In the present work, we provide biological evidences supporting the participation of NCW2 gene in the mechanism responsible for cell tolerance to polyhexamethylene biguanide (PHMB), an antifungal agent. The growth rate of yeast cells exposed to this agent was significantly reduced in ∆ncw2 strain and the mRNA levels of NCW2 gene in the presence of PHMB showed a 7-fold up-regulation. Moreover, lack of NCW2 gene turns yeast cell more resistant to zymolyase treatment, indicating that alterations in the β-glucan network do occur when Ncw2p is absent...
September 2016: Current Microbiology
Hilde Fjeld, Egil Lingaas
BACKGROUND Polyhexamethylene biguanide hydrochloride/polyhexanide/polyaminopropyl biguanide (PHMB) is used as a disinfectant and antiseptic. This article discusses the use of the substance as an antiseptic. We summarise published data on its antimicrobial effect in vitro and its clinical effect and safety when used on skin, wounds and mucosa.MATERIAL AND METHOD A literature search was conducted in PubMed for articles published in the last five years. Articles available as of June 2014 were considered.RESULTS Of 332 articles identified, 27 were included...
May 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Kantaraja Chindera, Manohar Mahato, Ashwani Kumar Sharma, Harry Horsley, Klaudia Kloc-Muniak, Nor Fadhilah Kamaruzzaman, Satish Kumar, Alexander McFarlane, Jem Stach, Thomas Bentin, Liam Good
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption by PHMB, we observed cell entry into a range of bacterial species, and treated bacteria displayed cell division arrest and chromosome condensation, suggesting DNA binding as an alternative antimicrobial mechanism...
2016: Scientific Reports
Alexander А Gusev, Alexey A Kudrinsky, Olga V Zakharova, Alexey I Klimov, Pavel M Zherebin, George V Lisichkin, Inna A Vasyukova, Albert N Denisov, Yurii A Krutyakov
Silver nanoparticles (AgNPs) are well-known bactericidal agents. However, information about the influence of AgNPs on the morphometric parameters and biochemical status of most important agricultural crops is limited. The present study reports the influence of AgNPs stabilized with cationic polymer polyhexamethylene biguanide hydrochloride (PHMB) on growth, development, and biochemical status of fodder beet Beta vulgaris L. under laboratory and greenhouse conditions. PHMB-stabilized AgNPs were obtained via sodium borohydride reduction of silver nitrate in an aqueous solution...
May 2016: Materials Science & Engineering. C, Materials for Biological Applications
Sharon Hunt
Here, a clinician compares 4 weeks of treatment with Prontosan Wound Gel with a subsequent 4 weeks of octenilin Wound Gel on a complex diabetic foot ulcer prone to recurrent infection. The data show that, following the switch to octenilin, the previously static wound started to heal.
March 2016: Journal of Wound Care
Peng Tian, Demin Xu, Xuanyong Liu
The rapid degradation of magnesium-based implants in physiological environments in vivo not only will quickly deteriorate their mechanical strengths but will also lead to a severe change of the micro-environment around the implants, which may cause the final failure of magnesium-based implants. In this work, a polycaprolactone (PCL) layer was prepared to seal the plasma electrolytic oxidization coating (PEO) to form a PEO/PCL composite coating on a biodegradable AZ31 magnesium alloy, followed by further surface functionalization with polydopamine...
May 1, 2016: Colloids and Surfaces. B, Biointerfaces
Supamas Napavichayanun, Rungnapha Yamdech, Pornanong Aramwit
In our previous work, we have attempted to develop a novel bacterial nanocellulose wound dressing which composed of both polyhexamethylene biguanide (PHMB) as an antimicrobial agent and sericin as an accelerative wound healing component. The loading sequence and concentration of PHMB and sericin were optimized to provide the wound dressing with the most effective antimicrobial activity and enhanced collagen production. In this study, further in vitro, in vivo, and clinical studies of this novel wound dressing were performed to evaluate its safety, efficacy, and applicability...
March 2016: Archives of Dermatological Research
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