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https://www.readbyqxmd.com/read/28277997/effect-of-antiseptic-irrigation-on-infection-rates-of-traumatic-soft-tissue-wounds-a-longitudinal-cohort-study
#1
B Roth, R Neuenschwander, F Brill, F Wurmitzer, C Wegner, O Assadian, A Kramer
OBJECTIVE: Acute traumatic wounds are contaminated with bacteria and therefore an infection risk. Antiseptic wound irrigation before surgical intervention is routinely performed for contaminated wounds. However, a broad variety of different irrigation solutions are in use. The aim of this retrospective, non-randomised, controlled longitudinal cohort study was to assess the preventive effect of four different irrigation solutions before surgical treatment, on wound infection in traumatic soft tissue wounds...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28266133/effectiveness-of-a-polyhexanide-irrigation-solution-on-methicillin-resistant-staphylococcus-aureus-biofilms-in-a-porcine-wound-model
#2
Stephen C Davis, Andrew Harding, Joel Gil, Fernando Parajon, Jose Valdes, Michael Solis, Alex Higa
Irrigation and removal of necrotic debris can be beneficial for proper healing. It is becoming increasingly evident that wounds colonized with biofilm forming bacteria, such as Staphylococcus aureus (SA), can be more difficult to eradicate. Here we report our findings of the effects of an irrigation solution containing propyl-betaine and polyhexanide (PHMB) on methicillin-resistant Staphylococcus aureus (MRSA) biofilms in a porcine wound model. Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin...
March 7, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28263055/dual-functional-polyethylene-glycol-b-polyhexanide-surface-coating-with-in-vitro-and-in-vivo-antimicrobial-and-antifouling-activities
#3
Zelun Zhi, Yajuan Su, Yuewei Xi, Liang Tian, Miao Xu, Qianqian Wang, Sara Padidan, Peng Li, Wei Huang
In recent years, microbial colonization on the surface of biomedical implants/devices has become a severe threat to human health. Herein, surface-immobilized guanidine derivative block copolymers create an antimicrobial and antifouling dual-functional coating. We report the preparation of an antimicrobial and antifouling block copolymer by the conjugation of polyhexanide (PHMB) with either allyl glycidyl ether or allyloxy polyethylene glycol (APEG; MW 1200 and 2400). The allyl glycidyl ether modified PHMB (A-PHMB) and allyloxy polyethylene glycol1200/2400 modified PHMB (APEG1200/2400-PHMB) copolymers were grafted onto a silicone rubber surface as a bottlebrush-like coating, respectively, using a plasma-UV-assisted surface-initiated polymerization...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28236482/cytotoxicity-and-molecular-effects-of-biocidal-disinfectants-quaternary-ammonia-glutaraldehyde-poly-hexamethylene-biguanide-hydrochloride-phmb-and-their-mixtures-in-vitro-and-in-zebrafish-eleuthero-embryos
#4
Verena Christen, Susanne Faltermann, Nadja Rebecca Brun, Petra Y Kunz, Karl Fent
Frequently used biocidal disinfectants, including quaternary ammonium compounds (QAC), glutaraldehyde and poly(hexamethylene biguanide) hydrochloride (PHMB), occur in the aquatic environment but their potential effects in fish are poorly known, in particular when occurring as mixtures. To investigate their joint activity, we assessed the cytotoxicity of three QACs (BAC, barquat and benzalkonium chloride), glutaraldehyde andPHMB by the MTT assay individually, followed by assessing binary and ternary mixtures in zebrafish liver cells (ZFL) and human liver cells (Huh7)...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28194876/biocidal-efficacy-of-multipurpose-solutions-against-gram-negative-organisms-associated-with-corneal-infiltrative-events
#5
Denise Callahan, Christopher Kovacs, Shawn Lynch, Marjorie Rah
BACKGROUND: Because corneal infiltrative events (CIEs) may result from bacterial components on contact lenses, which can come from contaminated lens cases, we evaluated the biocidal efficacy of five multipurpose solutions against Gram-negative commonly isolated and CIE-associated organisms. METHODS: Of the multipurpose solutions tested, one contained polyhexamethylene biguanide (PHMB)/polyquaternium-1 (PQ-1; Bausch & Lomb Incorporated: Biotrue), one contained alexidine dihydrochloride (alexidine)/PQ-1 (AMO: RevitaLens OcuTec) and three contained PQ-1/myristamidopropyl dimethylamine (MAPD; Alcon: Opti-Free PureMoist, PQ-1/MAPD-1; Opti-Free RepleniSH, PQ-1/MAPD-2; Opti-Free Express, PQ-1/MAPD-3)...
February 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28094221/synthesis-biological-evaluation-and-molecular-docking-analysis-of-2-phenyl-benzofuran-3-carboxamide-derivatives-as-potential-inhibitors-of-staphylococcus-aureus-sortase-a
#6
Wan He, Yong Zhang, Jian Bao, Xinxian Deng, Jennifer Batara, Shawn Casey, Qiuyuan Guo, Faqin Jiang, Lei Fu
In Gram-positive bacteria, Sortase A (Srt A) is a critical cysteine transpeptidase that is responsible for recognizing and assembling surface virulence proteins through the recognition of a LPXTG (leucine, proline, X, threonine, and glycine, where X is any amino acid) signal. Mutants lacking genes for Srt A attenuate infections without affecting microbial viability. Here a series of 2-phenyl-benzofuran-3-carboxamide derivatives were synthesized and identified as potent Srt A inhibitors. Activity assays revealed that multiple compounds exhibited excellent inhibitory activity against Srt A compared with known Sortase A inhibitor pHMB (IC50=130μM)...
December 25, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28028794/effect-of-liquid-crystalline-systems-containing-antimicrobial-compounds-on-infectious-skin-bacteria
#7
Carla Souza, Evandro Watanabe, Carolina Patrícia Aires, Marilisa Guimarães Lara
This study aimed (i) to prepare liquid crystalline systems (LCS) of glyceryl monooleate (GMO) and water containing antibacterial compounds and (ii) to evaluate their potential as drug delivery systems for topical treatment of bacterial infections. Therefore, LCS containing CPC (cetylpyridinium chloride) (LCS/CPC) and PHMB (poly(hexamethylene biguanide) hydrochloride) (LCS/PHMB) were prepared and the liquid crystalline phases were identified by polarizing light microscopy 24 h and 7 days after preparation...
December 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28003630/in-vitro-evaluation-of-the-biocompatibility-of-newly-synthesized-bis-quaternary-ammonium-compounds-with-spacer-structures-derived-from-pentaerythritol-or-hydroquinone
#8
Masashi Yamamoto, Takashi Takami, Reiko Matsumura, Alexander Dorofeev, Yoshihiko Hirata, Hideaki Nagamune
 With the object of developing new biocides milder for human use than the current antiseptics, we synthesized a series of bis-quaternary ammonium compounds (bis-QACs). The antimicrobial activity of the newly synthesized bis-QACs and common biocides used as antiseptics was compared by examining minimum inhibitory concentrations and minimum bactericidal concentrations (MBCs). Moreover, the cytotoxicity of these compounds against human cells was determined to calculate the biocompatibility index (BI) of these compounds...
2016: Biocontrol Science
https://www.readbyqxmd.com/read/27987754/incorporation-of-biguanide-compounds-into-poly-gl-b-poly-gl-co-tmc-co-cl-b-poly-gl-monofilament-surgical-sutures
#9
Yolanda Márquez, Tània Cabral, Alice Lorenzetti, Lourdes Franco, Pau Turon, Luís J Del Valle, Jordi Puiggalí
A new biodegradable coating was developed for bioabsorbable monofilament sutures. Specifically, a random copolymer having 35wt-% and 65wt-% of lactide and trimethylene carbonate units showed appropriate flexibility, stickiness and degradation rate, as well as capability to produce a complete and uniform coating. Monofilament sutures of polyglycolide-b-poly(glycolide-co-trimethylene carbonate-co-ε-caprolactone)-b-polyglycolide were loaded with chlorhexidine (CHX) and poly(hexamethylene biguanide) (PHMB) to explore the possibility to achieve antimicrobial activity without adverse cytotoxic effects...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27888770/the-effect-of-the-disulfideisomerase-domain-containing-protein-in-the-defense-against-polyhexamethylene-biguanide-of-highly-tolerant-acanthamoeba-at-the-trophozoite-stage
#10
Fu-Chin Huang, Tao-Shen Liu, Sung-Chou Li, Min-Hsiu Shih, Jyh-Wei Shin, Wei-Chen Lin
Acanthamoeba castellanii is a free-living protozoan pathogen capable of causing a blinding keratitis and fatal granulomatous encephalitis. Current treatment generally involves an hourly application of polyhexamethylene biguanide (PHMB) over a period of several days but this is not entirely effective against all strains/isolates. The tolerance mechanisms of PHMB in Acanthamoeba cells remain unclear. In this study, we found that the mRNA expression level of disulfideisomerase domain containing protein (PDI) increased rapidly in surviving cells of the highly PHMB-tolerant Acanthamoeba castellanii strain, NCKH_D, during PHMB treatment, but not in the ATCC standard strain...
December 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27876528/the-impact-of-lens-care-solutions-on-corneal-epithelial-changes-during-daily-silicone-hydrogel-contact-lens-wear-as-measured-by-in-vivo-confocal-microscopy
#11
RANDOMIZED CONTROLLED TRIAL
Xiaolin Zhang, Christine Marchetti, Jessica Lee, Yan Sun, Sara Debanne, Ying Jiang, Jami Kern, Mark Harrod, Beth Ann Benetz, Eric Pearlman, Loretta Szczotka-Flynn
PURPOSE: To assess corneal epithelial microstructure via confocal microscopy and determine if cellular changes are associated with lens care solutions during daily wear of silicone hydrogel contact lenses. METHODS: Corneal in vivo confocal microscopy with the Nidek ConfoScan4 was performed at baseline and after 5 months of lotrafilcon A daily contact lens wear. Enrolled participants were randomized to use either a polyhexamethylene biguanide (PHMB) preserved multipurpose care solution (MPS) or a peroxide based solution system...
February 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27844305/cytocompatibility-testing-of-cyclodextrin-functionalized-antimicrobial-textiles-a-comprehensive-approach
#12
Kirsten Reddersen, Susanne Finger, Michael Zieger, Cornelia Wiegand, Hans-Jürgen Buschmann, Peter Elsner, Uta-Christina Hipler
Functionalized textiles can be used in wound management to reduce the microbial burden in the wound area, to prevent wound infections, and to avoid cross-contamination between patients. In the present study, a comprehensive in vitro approach to enable the assessment of antibacterial activity of functionalized textiles and cytotoxicity of cyclodextrin (CD)-complexes with chlorhexidine diacetate (CHX), iodine (IOD), and polihexanide (PHMB) is suggested to evaluate their properties for supporting optimal conditions for wound healing...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27749743/method-for-bacterial-growth-and-ammonia-production-and-effect-of-inhibitory-substances-in-disposable-absorbent-hygiene-products
#13
Ulla Forsgren-Brusk, Birgitta Yhlen, Marie Blomqvist, Peter Larsson
PURPOSE: The purpose of this study was to evaluate a pragmatic laboratory method to provide a technique for developing incontinence products better able to reduce malodor when used in the clinical setting. METHODS: Bacterial growth and bacterially formed ammonia in disposable absorbent incontinence products was measured by adding synthetic urine inoculated with bacteria to test samples cut from the crotch area of the product. The inhibitory effect's of low pH (4...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27746371/in-vitro-inflammatory-effects-of-polyhexamethylene-biguanide-through-nf-%C3%AE%C2%BAb-activation-in-a549-cells
#14
Ha Ryong Kim, Da Young Shin, Kyu Hyuck Chung
Polyhexamethylene biguanide (PHMB) is a member of the polymeric guanidine family, which is used as a biocide and preservative in industrial, medicinal, and consumer products. Some studies reported that polyhexamethylene guanidine phosphate, which is also a member of the guanidine family, induced severe inflammation and fibrosis in the lungs. However, limited studies have evaluated the pulmonary toxicity of PHMB associated with inflammatory responses. The aim of this study was to elucidate the inflammatory responses and its mechanisms induced by PHMB in lung cells...
February 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27692497/can-dressings-soaked-with-polyhexanide-reduce-bacterial-loads-in-full-thickness-skin-grafting-a-randomized-controlled-trial
#15
Karim Saleh, Andreas Sonesson, Kerstin Persson, Kristian Riesbeck, Artur Schmidtchen
BACKGROUND: Polyhexamethylene biguanide (PHMB)-based antiseptic solutions can reduce bacterial loads in different clinical settings and are believed to lower risk of infections. OBJECTIVE: We sought to assess the efficacy of a PHMB-based solution in lowering bacterial loads of full-thickness skin grafting wounds and the risk of surgical site infections (SSIs). METHODS: In this double-blinded clinical trial, 40 patients planned for facial full-thickness skin grafting were randomized 1:1 to receive tie-over dressings soaked with either PHMB-based solution or sterile water...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27608742/the-effectiveness-of-topical-polyhexamethylene-biguanide-phmb-agents-for-the-treatment-of-chronic-wounds-a-systematic-review
#16
Eliot To, Rebecca Dyck, Stephanie Gerber, Shauna Kadavil, Kevin Y Woo
INTRODUCTION: This is the first systematic review to explore the evidence on PHMB and determine how effective this topical agent is for the treatment of chronic wounds. MATERIALS AND METHODS: PubMed, Ovid MEDLINE, CINAHL, Embase, the Cochrane library, and Scopus were searched for relevant articles published from 1946 to February 3, 2014, with no restrictions on publication status. ProQuest was searched for relevant dissertations, editorials, and conference abstracts...
September 10, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27601610/in-vitro-activity-of-manuka-honey-and-polyhexamethylene-biguanide-on-filamentous-fungi-and-toxicity-to-human-cell-lines
#17
Joseph M Yabes, Brian K White, Clinton K Murray, Carlos J Sanchez, Katrin Mende, Miriam L Beckius, Wendy C Zera, Joseph C Wenke, Kevin S Akers
Soft-tissue invasive fungal infections are increasingly recognized as significant entities directly contributing to morbidity and mortality. They complicate clinical care, requiring aggressive surgical debridement and systemic antifungal therapy. To evaluate new topical approaches to therapy, we examined the antifungal activity and cytotoxicity of Manuka Honey (MH) and polyhexamethylene biguanide (PHMB). The activities of multiple concentrations of MH (40%, 60%, 80%) and PHMB (0.01%, 0.04%, 0.1%) against 13 clinical mould isolates were evaluated using a time-kill assay between 5 min and 24 h...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27598555/antimicrobial-efficacy-of-multipurpose-disinfecting-solutions-in-the-presence-of-contact-lenses-and-lens-cases
#18
Manal M Gabriel, Cindy McAnally, John Bartell
OBJECTIVE: The aim of this study was to use antimicrobial efficacy endpoint methodology to determine compatibility of multipurpose disinfecting solutions (MPSs), lens cases, and hydrogel lenses for disinfection (AEEMC) against International Organization for Standardization (ISO)-specified microorganisms and clinical ocular isolates of Stenotrophomonas maltophilia. METHODS: Six MPSs (PQ/Aldox 1, 2, and 3; PQ/Alexidine; PQ/PHMB; and PHMB) were challenged against ISO-specified microorganisms and S...
September 2, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27536976/evaluation-of-protamine-as-a-disinfectant-for-contact-lenses
#19
Mahesh K Bandara, Simin Masoudi, Hua Zhu, Rani Bandara, Mark D P Willcox
PURPOSE: To investigate the ability of protamine, alone or in combination with other antimicrobial agents, to kill bacteria and fungi associated with contact lens-related keratitis. METHODS: The International Organization for Standardization 14729:2001 procedure was used to test the antimicrobial activity of solutions of protamine (23-228 μM) with and without polyhexamethylene biguanide (PHMB) and ethylenediamine tetra-acetic acid (EDTA). The recommended ISO panel of microbes along with six clinical isolates was tested...
August 17, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27532788/effectiveness-of-polyhexamethylene-biguanide-impregnated-dressing-in-wound-healing-a-systematic-review-protocol
#20
Mary Tan, Siti Zubaidah Mordiffi, Dora Lang
The objective of this review is to review and synthesize evidence on the effectiveness of polyhexamethylene biguanide (PHMB) impregnated dressing in wound treatment for patients with chronic or acute wounds, compared with standard dressings or any other antimicrobial dressings.Specifically the questions for this review are.
July 2016: JBI Database of Systematic Reviews and Implementation Reports
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