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https://www.readbyqxmd.com/read/28609225/preparation-of-nano-cationic-liposome-as-carrier-membrane-for-polyhexamethylene-biguanide-chloride-through-various-methods-utilizing-higher-antibacterial-activities-with-low-cell-toxicity
#1
Elnaz Ahani, Majid Montazer, Tayebeh Toliyat, Mahnaz Mahmoudi Rad, Tina Harifi
This study suggested successful encapsulation of polyhexamethylene biguanide chloride (PHMB) into nano cationic liposome as a biocompatible antibacterial agent with less cytotoxicity and higher activities. Phosphatidylcholine, cholesterol and stearylamine were used to prepare nano cationic liposome using thin film hydration method along with sonication or homogeniser. Sonication was more effective in PHMB loaded nano cationic liposome preparation with smaller size (34 nm). FTIR, (1)H NMR and XRD analyses were used to confirm the encapsulation of PHMB into nano cationic liposome...
March 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28526171/chlorhexidine-gluconate-or-polyhexamethylene-biguanide-disc-dressing-to-reduce-the-incidence-of-central-line-associated-bloodstream-infection-a-feasibility-randomized-controlled-trial-the-clabsi-trial
#2
J Webster, E Larsen, N Marsh, A Choudhury, P Harris, C M Rickard
BACKGROUND: A number of antimicrobial-impregnated discs to prevent central-line-associated bloodstream infection (CLABSI) are marketed but it is unclear which disc is most effective. AIM: To investigate the feasibility and safety of comparing two antimicrobial-impregnated discs to prevent CLABSI. METHODS: A single-centre, parallel group, randomized controlled trial was conducted in a 929-bed tertiary referral hospital. Hospital inpatients requiring a peripherally inserted central catheter were randomized to chlorhexidine gluconate (CHG) or polyhexamethylene biguanide (PHMB) disc dressing group...
July 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28486311/free-living-amoebae-keratitis
#3
Antonio Pinna, Tiziana Porcu, Francesco Boscia, Antonella Cano, Giuseppe Erre, Antonella Mattana
PURPOSE: To describe the diagnostic and clinical features and treatment results in 43 consecutive patients with microbiologically proven free-living amoebae (FLA) keratitis. METHODS: In this hospital-based, prospective case series, corneal scrapings from 43 patients with presumed amoebic keratitis were plated on nonnutrient agar. Amoebic isolates were identified morphologically and by the polymerase chain reaction. All patients with culture-proven FLA keratitis were treated with polyhexamethylene biguanide (PHMB) 0...
July 2017: Cornea
https://www.readbyqxmd.com/read/28483711/opinion-of-the-scientific-committee-on-consumer-safety-sccs-final-opinion-on-polyaminopropyl-biguanide-phmb-in-cosmetic-products%C3%A2-%C3%A2-submission-iii
#4
Vera Rogiers
No abstract text is available yet for this article.
May 5, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28475440/the-effect-of-negative-pressure-wound-therapy-with-antibacterial-dressings-or-antiseptics-on-an-in-vitro-wound-model
#5
J Matiasek, K J Domig, G Djedovic, R Babeluk, O Assadian
OBJECTIVE: The aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (NPWT), with and without antimicrobial dressings (polyhexanide, silver), against NPWT instillation of octenidine. METHOD: Experimental wounds produced in an in vitro porcine wound model were homogenously contaminated with bacterial suspension and treated with NPWT and different options...
May 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28422216/design-and-preparation-of-efficient-hydroisomerization-catalysts-by-the-formation-of-stable-sapo-11-molecular-sieve-nanosheets-with-10-20-nm-thickness-and-partially-blocked-acidic-sites
#6
Fen Zhang, Yan Liu, Qi Sun, Zhifeng Dai, Hermann Gies, Qinming Wu, Shuxiang Pan, Chaoqun Bian, Zhijian Tian, Xiangju Meng, Yi Zhang, Xiaodong Zou, Xianfeng Yi, Anmin Zheng, Liang Wang, Feng-Shou Xiao
SAPO-11 nanosheets with partially filled micropores (N-SAPO-11) and a thickness of 10-20 nm were synthesized using polyhexamethylene biguanide hydrochloride (PHMB) as a mesoporogen and di-n-propylamine (DPA) as a microporous template. After Pt loading (0.5 wt%), the Pt/N-SAPO-11 catalyst exhibits higher selectivity for the isomers and lower selectivity for cracking products than conventional Pt/SAPO-11 catalysts in the hydroisomerization of n-dodecane.
April 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28420291/a-study-of-long-term-stability-and-antimicrobial-activity-of-chlorhexidine-polyhexamethylene-biguanide-and-silver-nanoparticle-incorporated-in-sericin-based-wound-dressing
#7
Sumate Ampawong, Pornanong Aramwit
In this study, three kinds of antiseptics which were 0.05% chlorhexidine, 0.2% polyhexamethylene biguanide (PHMB), or 200 ppm silver nanoparticle was introduced to incorporate in the sericin-based scaffold to produce the antimicrobial dressing for the treatment of infected chronic wound. The effects of antiseptic incorporation on the stability, release of sericin, and short-term and long-term (6 months) antimicrobial activity of the sericin dressing against gram-negative and gram-positive bacteria were investigated...
April 25, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28379100/albumin-reduces-the-antibacterial-efficacy-of-wound-antiseptics-against-staphylococcus-aureus
#8
N Kapalschinski, H M Seipp, M Kückelhaus, K K Harati, J J Kolbenschlag, A Daigeler, F Jacobsen, M Lehnhardt, T Hirsch
OBJECTIVE: The influence of proteins on the efficacy of antiseptic solutions has been rarely investigated even though exudate can contain high levels of protien. The aim of this study was to analyse the antibacterial efficacy of commonly used solutions in the presence of albumin protein. METHOD: Using Staphylococcus aureus in a standardised quantitative suspension assay, the antibacterial effects of poly (1-(2-oxo-1-pyrrolidinyl) ethylene)-iodine (PVP-I) and octenidin-dihydrochloride/phenoxyethanol (OCT/PE) were analysed in the presence of 0-3% bovine serum albumin (BSA)...
April 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28370821/antibacterial-activity-of-polihexanide-formulations-in-a-co-culture-of-hacat-keratinocytes-and-staphylococcus-aureus-and-at-different-ph-levels
#9
Cornelia Wiegand, Thomas Eberlein, Anneke Andriessen
Complex stalled wounds feature an alkaline milieu that favors tissue destruction and microbial growth. The presence of bacteria in turn perpetuates the inflammatory response. However, only limited knowledge exists of pH dependency on the antibacterial efficacy of polyhexamethylene biguanide (PHMB) or the influence of surfactants or delivery vehicle used in antiseptic formulations. So far, PHMB alone has been shown to protect the keratinocytes from bacterial damage in such a co-culture system as well as exhibiting increased antimicrobial activity at higher pH values...
April 1, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28277997/effect-of-antiseptic-irrigation-on-infection-rates-of-traumatic-soft-tissue-wounds-a-longitudinal-cohort-study
#10
B Roth, R Neuenschwander, F Brill, F Wurmitzer, C Wegner, O Assadian, A Kramer
OBJECTIVE: Acute traumatic wounds are contaminated with bacteria and therefore an infection risk. Antiseptic wound irrigation before surgical intervention is routinely performed for contaminated wounds. However, a broad variety of different irrigation solutions are in use. The aim of this retrospective, non-randomised, controlled longitudinal cohort study was to assess the preventive effect of four different irrigation solutions before surgical treatment, on wound infection in traumatic soft tissue wounds...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28266133/effectiveness-of-a-polyhexanide-irrigation-solution-on-methicillin-resistant-staphylococcus-aureus-biofilms-in-a-porcine-wound-model
#11
Stephen C Davis, Andrew Harding, Joel Gil, Fernando Parajon, Jose Valdes, Michael Solis, Alex Higa
Irrigation and removal of necrotic debris can be beneficial for proper healing. It is becoming increasingly evident that wounds colonized with biofilm forming bacteria, such as Staphylococcus aureus (SA), can be more difficult to eradicate. Here we report our findings of the effects of an irrigation solution containing propyl-betaine and polyhexanide (PHMB) on methicillin-resistant Staphylococcus aureus (MRSA) biofilms in a porcine wound model. Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin...
March 7, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28263055/dual-functional-polyethylene-glycol-b-polyhexanide-surface-coating-with-in-vitro-and-in-vivo-antimicrobial-and-antifouling-activities
#12
Zelun Zhi, Yajuan Su, Yuewei Xi, Liang Tian, Miao Xu, Qianqian Wang, Sara Padidan, Peng Li, Wei Huang
In recent years, microbial colonization on the surface of biomedical implants/devices has become a severe threat to human health. Herein, surface-immobilized guanidine derivative block copolymers create an antimicrobial and antifouling dual-functional coating. We report the preparation of an antimicrobial and antifouling block copolymer by the conjugation of polyhexanide (PHMB) with either allyl glycidyl ether or allyloxy polyethylene glycol (APEG; MW 1200 and 2400). The allyl glycidyl ether modified PHMB (A-PHMB) and allyloxy polyethylene glycol1200/2400 modified PHMB (APEG1200/2400-PHMB) copolymers were grafted onto a silicone rubber surface as a bottlebrush-like coating, respectively, using a plasma-UV-assisted surface-initiated polymerization...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28236482/cytotoxicity-and-molecular-effects-of-biocidal-disinfectants-quaternary-ammonia-glutaraldehyde-poly-hexamethylene-biguanide-hydrochloride-phmb-and-their-mixtures-in-vitro-and-in-zebrafish-eleuthero-embryos
#13
Verena Christen, Susanne Faltermann, Nadja Rebecca Brun, Petra Y Kunz, Karl Fent
Frequently used biocidal disinfectants, including quaternary ammonium compounds (QAC), glutaraldehyde and poly(hexamethylene biguanide) hydrochloride (PHMB), occur in the aquatic environment but their potential effects in fish are poorly known, in particular when occurring as mixtures. To investigate their joint activity, we assessed the cytotoxicity of three QACs (BAC, barquat and benzalkonium chloride), glutaraldehyde andPHMB by the MTT assay individually, followed by assessing binary and ternary mixtures in zebrafish liver cells (ZFL) and human liver cells (Huh7)...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28194876/biocidal-efficacy-of-multipurpose-solutions-against-gram-negative-organisms-associated-with-corneal-infiltrative-events
#14
Denise Callahan, Christopher Kovacs, Shawn Lynch, Marjorie Rah
BACKGROUND: Because corneal infiltrative events (CIEs) may result from bacterial components on contact lenses, which can come from contaminated lens cases, we evaluated the biocidal efficacy of five multipurpose solutions against Gram-negative commonly isolated and CIE-associated organisms. METHODS: Of the multipurpose solutions tested, one contained polyhexamethylene biguanide (PHMB)/polyquaternium-1 (PQ-1; Bausch & Lomb Incorporated: Biotrue), one contained alexidine dihydrochloride (alexidine)/PQ-1 (AMO: RevitaLens OcuTec) and three contained PQ-1/myristamidopropyl dimethylamine (MAPD; Alcon: Opti-Free PureMoist, PQ-1/MAPD-1; Opti-Free RepleniSH, PQ-1/MAPD-2; Opti-Free Express, PQ-1/MAPD-3)...
July 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28094221/synthesis-biological-evaluation-and-molecular-docking-analysis-of-2-phenyl-benzofuran-3-carboxamide-derivatives-as-potential-inhibitors-of-staphylococcus-aureus-sortase-a
#15
Wan He, Yong Zhang, Jian Bao, Xinxian Deng, Jennifer Batara, Shawn Casey, Qiuyuan Guo, Faqin Jiang, Lei Fu
In Gram-positive bacteria, Sortase A (Srt A) is a critical cysteine transpeptidase that is responsible for recognizing and assembling surface virulence proteins through the recognition of a LPXTG (leucine, proline, X, threonine, and glycine, where X is any amino acid) signal. Mutants lacking genes for Srt A attenuate infections without affecting microbial viability. Here a series of 2-phenyl-benzofuran-3-carboxamide derivatives were synthesized and identified as potent Srt A inhibitors. Activity assays revealed that multiple compounds exhibited excellent inhibitory activity against Srt A compared with known Sortase A inhibitor pHMB (IC50=130μM)...
February 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28028794/effect-of-liquid-crystalline-systems-containing-antimicrobial-compounds-on-infectious-skin-bacteria
#16
Carla Souza, Evandro Watanabe, Carolina Patrícia Aires, Marilisa Guimarães Lara
This study aimed (i) to prepare liquid crystalline systems (LCS) of glyceryl monooleate (GMO) and water containing antibacterial compounds and (ii) to evaluate their potential as drug delivery systems for topical treatment of bacterial infections. Therefore, LCS containing CPC (cetylpyridinium chloride) (LCS/CPC) and PHMB (poly(hexamethylene biguanide) hydrochloride) (LCS/PHMB) were prepared and the liquid crystalline phases were identified by polarizing light microscopy 24 h and 7 days after preparation...
December 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28003630/in-vitro-evaluation-of-the-biocompatibility-of-newly-synthesized-bis-quaternary-ammonium-compounds-with-spacer-structures-derived-from-pentaerythritol-or-hydroquinone
#17
Masashi Yamamoto, Takashi Takami, Reiko Matsumura, Alexander Dorofeev, Yoshihiko Hirata, Hideaki Nagamune
 With the object of developing new biocides milder for human use than the current antiseptics, we synthesized a series of bis-quaternary ammonium compounds (bis-QACs). The antimicrobial activity of the newly synthesized bis-QACs and common biocides used as antiseptics was compared by examining minimum inhibitory concentrations and minimum bactericidal concentrations (MBCs). Moreover, the cytotoxicity of these compounds against human cells was determined to calculate the biocompatibility index (BI) of these compounds...
2016: Biocontrol Science
https://www.readbyqxmd.com/read/27987754/incorporation-of-biguanide-compounds-into-poly-gl-b-poly-gl-co-tmc-co-cl-b-poly-gl-monofilament-surgical-sutures
#18
Yolanda Márquez, Tània Cabral, Alice Lorenzetti, Lourdes Franco, Pau Turon, Luís J Del Valle, Jordi Puiggalí
A new biodegradable coating was developed for bioabsorbable monofilament sutures. Specifically, a random copolymer having 35wt-% and 65wt-% of lactide and trimethylene carbonate units showed appropriate flexibility, stickiness and degradation rate, as well as capability to produce a complete and uniform coating. Monofilament sutures of polyglycolide-b-poly(glycolide-co-trimethylene carbonate-co-ε-caprolactone)-b-polyglycolide were loaded with chlorhexidine (CHX) and poly(hexamethylene biguanide) (PHMB) to explore the possibility to achieve antimicrobial activity without adverse cytotoxic effects...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27888770/the-effect-of-the-disulfideisomerase-domain-containing-protein-in-the-defense-against-polyhexamethylene-biguanide-of-highly-tolerant-acanthamoeba-at-the-trophozoite-stage
#19
Fu-Chin Huang, Tao-Shen Liu, Sung-Chou Li, Min-Hsiu Shih, Jyh-Wei Shin, Wei-Chen Lin
Acanthamoeba castellanii is a free-living protozoan pathogen capable of causing a blinding keratitis and fatal granulomatous encephalitis. Current treatment generally involves an hourly application of polyhexamethylene biguanide (PHMB) over a period of several days but this is not entirely effective against all strains/isolates. The tolerance mechanisms of PHMB in Acanthamoeba cells remain unclear. In this study, we found that the mRNA expression level of disulfideisomerase domain containing protein (PDI) increased rapidly in surviving cells of the highly PHMB-tolerant Acanthamoeba castellanii strain, NCKH_D, during PHMB treatment, but not in the ATCC standard strain...
December 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27876528/the-impact-of-lens-care-solutions-on-corneal-epithelial-changes-during-daily-silicone-hydrogel-contact-lens-wear-as-measured-by-in-vivo-confocal-microscopy
#20
RANDOMIZED CONTROLLED TRIAL
Xiaolin Zhang, Christine Marchetti, Jessica Lee, Yan Sun, Sara Debanne, Ying Jiang, Jami Kern, Mark Harrod, Beth Ann Benetz, Eric Pearlman, Loretta Szczotka-Flynn
PURPOSE: To assess corneal epithelial microstructure via confocal microscopy and determine if cellular changes are associated with lens care solutions during daily wear of silicone hydrogel contact lenses. METHODS: Corneal in vivo confocal microscopy with the Nidek ConfoScan4 was performed at baseline and after 5 months of lotrafilcon A daily contact lens wear. Enrolled participants were randomized to use either a polyhexamethylene biguanide (PHMB) preserved multipurpose care solution (MPS) or a peroxide based solution system...
February 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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