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https://www.readbyqxmd.com/read/29748803/hexavalent-chromium-removal-from-aqueous-solution-using-functionalized-chitosan-as-a-novel-nano-adsorbent-modeling-and-optimization-kinetic-isotherm-and-thermodynamic-studies-and-toxicity-testing
#1
Hassan Aslani, Tayebeh Ebrahimi Kosari, Simin Naseri, Ramin Nabizadeh, Mohammad Khazaei
Hexavalent chromium is a highly toxic metal that can enter drinking water sources. Chitosan, which contains amino and hydroxyl functional groups, is considered an appropriate candidate to remove heavy metals through absorption. In this study, a novel adsorbent, magnetic nanoparticles of chitosan modified with polyhexamethylene biguanide (Ch-PHMB NPs) was synthesized and was used to successfully remove chromium from aqueous solution. Quadratic models with independent variables including pH, adsorbent dosage, time, and the initial concentration of chromium were proposed through RSM to describe the behavior of both magnetic chitosan (M-Ch) and Ch-PHMB NPs in Cr(VI) removal...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29682408/stability-of-an-ophthalmic-formulation-of-polyhexamethylene-biguanide-in-gamma-sterilized-and-ethylene-oxide-sterilized-low-density-polyethylene-multidose-eyedroppers
#2
Yassine Bouattour, Philip Chennell, Mathieu Wasiak, Mireille Jouannet, Valérie Sautou
Background: Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated PHMB stability data severely limits their conservation by imposing short expiration dates after preparation. In this study we aim to assess the physicochemical and microbiological stability of a 0.2 mg/mL PHMB eye drop formulation stored in two kinds of polyethylene bottles at two different temperatures...
2018: PeerJ
https://www.readbyqxmd.com/read/29666023/the-influence-of-lens-care-systems-on-eyelid-tissue-changes-during-silicone-hydrogel-contact-lens-wear
#3
Michel Guillon, Cécile Maissa, Stéphanie Wong, Trisha Patel, Renée Garofalo
PURPOSE: To compare the effects of a hydrogen peroxide (H2 O2 )-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses. METHODS: A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n = 39) or PureVision® (balafilcon A; n = 35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh™ multi-purpose solution (n = 37 each)...
April 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#4
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29528760/the-effect-of-antiamoebic-agents-on-viability-proliferation-and-migration-of-human-epithelial-cells-keratocytes-and-endothelial-cells-in-vitro
#5
Lei Shi, Tanja Stachon, Berthold Seitz, Stefan Wagenpfeil, Achim Langenbucher, Nóra Szentmáry
PURPOSE: To analyze the effect of diamidines (hexamidine-diisethionat (HD), propamidin-isethionate (PD), dibromopropamidine-diisethionat (DD)), and biguanides (polyhexamethylen biguanid (PHMB), chlorhexidine (CH)) on human corneal epithelial cell, keratocyte and endothelial cell viability, proliferation, and migration, in vitro. METHODS: For epithelial and endothelial cells a human cell line and for keratocytes primary cultures were used (n = 6 each). We used 3...
June 2018: Current Eye Research
https://www.readbyqxmd.com/read/29509112/effectiveness-of-a-non-medicated-wound-dressing-on-attached-and-biofilm-encased-bacteria-laboratory-and-clinical-evidence
#6
Mark G Rippon, Alan A Rogers, Laura Sellars, Kathryn M Styles, Samantha Westgate
OBJECTIVE: The objective of this study was to evaluate the ability of a non medicated, hydro-responsive wound dressing (HRWD) to effectively aid in the removal of bacteria known to reside (and cause infections) within the wound environment. METHOD: A series of in vitro studies were undertaken using Staphylococcus aureus and Pseudomonas aeruginosa biofilms to evaluate the capabilities of the HRWD to disrupt and disperse biofilms. RESULTS: Biofilms can be broken up and dispersed by HRWD and both Staphylococcus aureus and Pseudomonas aeruginosa numbers can be reduced by a greater than log2 reduction in the presence of HRWD...
March 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29369228/consequences-of-preservative-uptake-and-release-by-contact-lenses
#7
Carol A Morris, Inna A Maltseva, Victoria A Rogers, Jing Ni, Kathleen T Khong, Charles B Derringer, Melanie D George, Andrew S Luk
OBJECTIVES: To assess contact lens preservative uptake and release from multipurpose solutions (MPS) and subsequent acquisition of lens antibacterial activity. METHODS: Kinetics of uptake and release of poly (hexamethylene biguanide hydrochloride) (PHMB) or polyquaternium-1 (PQ-1) from various contact lenses were studied initially with the pure compounds and then after soaking in MPS containing these compounds. Lenses soaked in MPS were tested for antibacterial activity...
January 22, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29363857/influence-of-human-acute-wound-fluid-on-the-antibacterial-efficacy-of-different-antiseptic-polyurethane-foam-dressings-an-in-vitro-analysis
#8
Julian-Dario Rembe, Carolin Fromm-Dornieden, Julia Böhm, Ewa K Stuermer
Treating infected acute and/or chronic wounds still represents a major challenge in medical care. Various interactions of antiseptic dressings with wound environments regarding antimicrobial efficacy remain unclear. Therefore, this work aimed to investigate the influence of human acute wound fluid (AWF) on the antimicrobial performance of different antiseptic foam dressings in vitro against typical bacterial wound pathogens. Eight antiseptic polyurethane foam dressings containing either a silver formulation or a polyhexamethylene-biguanide (PHMB) were assessed regarding their antimicrobial potency against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using a modified time-kill assay based on ISO EN 20743...
January 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29350654/autolytic-debridement-and-management-of-bacterial-load-with-an-occlusive-hydroactive-deressing-impregnated-with-polyhexamethylene-biguanide
#9
Stefano Mancini, Roberto Cuomo, Mauro Poggialini, Carlo D'Aniello, Giuseppe Botta
BACKGROUND: Debridement and control of bacterial load are key-points of wound care. The aim of this study is to evaluate the effectiveness of autolytic debridement and management of bacterial load (bioburden) of an occlusive hydro-active dressing impregnated with polyhexamethylene biguanide (PHMB). METHODS: We used an occlusive dressing of hydro-active for leg ulcers' treatment (TenderWet-plus® - Hartmann).  Inclusion criteria were: presence of a fibrinous ulcer with multiple etiopathogenesis, in absence of clinical infection, no hypersecretion and diameter within 5 cm...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29305328/effect-of-polyhexamethylene-biguanide-on-rat-liver
#10
Aparajita Chowdhury, Lora L Arnold, Zemin Wang, Karen L Pennington, Puttappa Dodmane, Ana Paula Farragut-Cardoso, James E Klaunig, Daniel Cros, Edmond E Creppy, Samuel M Cohen
Polyhexamethylene biguanide (PHMB), an amphiphilic polymeric biocide, increased liver tumor incidence in male and female rats at 1000 and 1500 mg/L in drinking water, but not at 500 mg/L in previous studies. In another study, PHMB administered in diet at 4000 mg/kg was negative for hepatocellular tumors. The present studies evaluated bioavailability and distribution of PHMB administered in drinking water and diet and possible modes of action (MOA). PHMB in drinking water was unpalatable during the first 3 days, resulting in markedly decreased food consumption and decreased body weight...
March 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29248316/cytotoxic-and-inflammatory-effects-of-contact-lens-solutions-on-human-corneal-epithelial-cells-in-vitro
#11
Sarah Oh, David J McCanna, Lakshman N Subbaraman, Lyndon W Jones
PURPOSE: To ascertain the effect that four contact lens (CL) multipurpose solutions (MPS) have on the viability and release of pro-inflammatory cytokines from human corneal epithelial cells (HCEC). METHODS: HCEC were exposed to four different MPS at various concentrations for 18 hours. The cells were also exposed to phosphate buffer, borate buffer, and PHMB. The cell viability was evaluated using the alamarBlue assay. The release of pro-inflammatory cytokines was measured using a Multiplex electrochemiluminescent assay...
December 13, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29230408/fungicidal-corrosive-and-mutational-effects-of-polyhexamethylene-biguanide-combined-with-1-bromo-3-chloro-5-5-dimethylimidazolidine-2-4-dione
#12
Bing Niu, Wan Huai, Zhirui Deng, Qin Chen
Background: The disinfectants polyhexamethylene biguanide (PHMB) and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) each have limitations. So far, their combined usage has not been examined. In this study, the fungicidal activity of combined disinfectant using PHMB and BCDMH, named PB, against Candida albicans was evaluated. Methods: Suspension quantitative fungicidal test and viable fungi count were used to test fungicidal effects against C. albicans ...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29029044/enhanced-killing-of-escherichia-coli-using-a-combination-of-polyhexamethylene-biguanide-hydrochloride-and-1-bromo-3-chloro-5-5-dimethylimidazolidine-2-4-dione
#13
Wan Huai, Zhirui Deng, Wenshu Lin, Qin Chen
The bactericidal activities of polyhexamethylene biguanide hydrochloride (PHMB), 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) and the combination of the two (designated as PB) were compared using Escherichia coli as the test organism. PB exhibited strong bactericidal activity: 10 mg/L PHMB combined with 8 mg/L BCDMH resulted in approximately 5.74 log10 reduction (LR), whereas 320 mg/L PHMB or 20 mg/L BCDMH was about 5.53 and 6.56 LR, respectively. Analyses using scanning electron microscopy, flow cytometry and atomic absorption spectroscopy indicated that PB, PHMB and BCDMH disrupted cell membranes and changed membrane structure and permeability, resulting in the leakage of intracellular soluble proteins and ions...
November 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29025650/ephemeral-biogels-to-control-anti-biofilm-agent-delivery-from-conception-to-the-construction-of-an-active-dressing
#14
Elodie Lefebvre, Pierre Lembre, Julien Picard, Lamia El-Guermah, Damien Seyer, Véronique Larreta Garde
Chronic wound colonization by bacterial biofilms is common and can cause various complications. An anti-biofilm strategy was developed around the co-entrapment of a commercially available antiseptic, PHMB (polyhexamethylene biguanide 4mgmL-1 ), with EDTA (Ethylen diamine tetra acetic acid, 20mM) in a gelatin gel. The two active compounds act synergistically against bacterial biofilms, but their efficiency is strongly reduced (16-fold) when entrapped inside the 5% gelatin gel, and they weaken the mechanical properties (50-fold) of the gel...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28917870/ultra-high-pressure-modified-cellulosic-fibres-with-antimicrobial-properties
#15
Ana M Salgueiro, Mauro D Santos, Jorge A Saraiva, Filipe Almeida, Isabel Sousa, João Tedim, Helena I S Nogueira, Dmitry V Evtuguin
In this work bleached E. globulus kraft pulp was doped with polyhexamethylene biguanide (PHMB) from an aqueous solution or from a suspension of silica capsules (PHMB@silica) by impregnation under atmospheric or ultra-high pressure (UHP) conditions (500MPa). The antimicrobial properties of pulps were evaluated towards gram-negative E. coli and gram-positive L. innocua bacteria. PHMB loads below 500mg per kg of pulp revealed negligible bacteriostatic properties, whereas PHMB loads of ca 3000-4000mg per kg demonstrated bactericidal properties of pulp without significant deterioration of its mechanical strength...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28814284/effect-of-poly-hexamethylene-biguanide-hydrochloride-phmb-treated-non-sterile-medical-gloves-upon-the-transmission-of-streptococcus-pyogenes-carbapenem-resistant-e-coli-mrsa-and-klebsiella-pneumoniae-from-contact-surfaces
#16
S Ali, A P R Wilson
BACKGROUND: Reduction of accidental contamination of the near-patient environment has potential to reduce acquisition of healthcare-associated infection(s). Although medical gloves should be removed when soiled or touching the environment, compliance is variable. The use of antimicrobial-impregnated medical gloves could reduce the horizontal-transfer of bacterial contamination between surfaces. AIM: Determine the activity of antimicrobial-impregnated gloves against common hospital pathogens: Streptococcus pyogenes, carbapenem-resistant E...
August 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28609225/preparation-of-nano-cationic-liposome-as-carrier-membrane-for-polyhexamethylene-biguanide-chloride-through-various-methods-utilizing-higher-antibacterial-activities-with-low-cell-toxicity
#17
Elnaz Ahani, Majid Montazer, Tayebeh Toliyat, Mahnaz Mahmoudi Rad, Tina Harifi
This study suggested successful encapsulation of polyhexamethylene biguanide chloride (PHMB) into nano cationic liposome as a biocompatible antibacterial agent with less cytotoxicity and higher activities. Phosphatidylcholine, cholesterol and stearylamine were used to prepare nano cationic liposome using thin film hydration method along with sonication or homogeniser. Sonication was more effective in PHMB loaded nano cationic liposome preparation with smaller size (34 nm). FTIR, 1 H NMR and XRD analyses were used to confirm the encapsulation of PHMB into nano cationic liposome...
March 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28526171/chlorhexidine-gluconate-or-polyhexamethylene-biguanide-disc-dressing-to-reduce-the-incidence-of-central-line-associated-bloodstream-infection-a-feasibility-randomized-controlled-trial-the-clabsi-trial
#18
RANDOMIZED CONTROLLED TRIAL
J Webster, E Larsen, N Marsh, A Choudhury, P Harris, C M Rickard
BACKGROUND: A number of antimicrobial-impregnated discs to prevent central-line-associated bloodstream infection (CLABSI) are marketed but it is unclear which disc is most effective. AIM: To investigate the feasibility and safety of comparing two antimicrobial-impregnated discs to prevent CLABSI. METHODS: A single-centre, parallel group, randomized controlled trial was conducted in a 929-bed tertiary referral hospital. Hospital inpatients requiring a peripherally inserted central catheter were randomized to chlorhexidine gluconate (CHG) or polyhexamethylene biguanide (PHMB) disc dressing group...
July 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28486311/free-living-amoebae-keratitis
#19
Antonio Pinna, Tiziana Porcu, Francesco Boscia, Antonella Cano, Giuseppe Erre, Antonella Mattana
PURPOSE: To describe the diagnostic and clinical features and treatment results in 43 consecutive patients with microbiologically proven free-living amoebae (FLA) keratitis. METHODS: In this hospital-based, prospective case series, corneal scrapings from 43 patients with presumed amoebic keratitis were plated on nonnutrient agar. Amoebic isolates were identified morphologically and by the polymerase chain reaction. All patients with culture-proven FLA keratitis were treated with polyhexamethylene biguanide (PHMB) 0...
July 2017: Cornea
https://www.readbyqxmd.com/read/28483711/opinion-of-the-scientific-committee-on-consumer-safety-sccs-final-opinion-on-polyaminopropyl-biguanide-phmb-in-cosmetic-products%C3%A2-%C3%A2-submission-iii
#20
Vera Rogiers
No abstract text is available yet for this article.
May 5, 2017: Regulatory Toxicology and Pharmacology: RTP
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