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https://www.readbyqxmd.com/read/29761889/a-novel-human-s10f-hsp20-mutation-induces-lethal-peripartum-cardiomyopathy
#1
Guan-Sheng Liu, George Gardner, George Adly, Min Jiang, Wen-Feng Cai, Chi Keung Lam, Fawzi Alogaili, Nathan Robbins, Jack Rubinstein, Evangelia G Kranias
Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Previous findings showed that cardiac-specific overexpression of this mutant were associated with reduced autophagy, left ventricular dysfunction and early death in male mice. However, this study indicates that females have normal function with no alterations in autophagy but died within a week after 1-4 pregnancies...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29750253/transport-stress-induces-heart-damage-in-newly-hatched-chicks-via-blocking-the-cytoprotective-heat-shock-response-and-augmenting-nitric-oxide-production
#2
F Sun, Y-Z Zuo, J Ge, J Xia, X-N Li, J Lin, C Zhang, H-L Xu, J-L Li
Transport stress affects the animal's metabolism and psychological state. As a pro-survival pathway, the heat shock response (HSR) protects healthy cells from stressors. However, it is unclear whether the HSR plays a role in transport stress-induced heart damage. To evaluate the effects of transport stress on heart damage and HSR protection, newly hatched chicks were treated with transport stress for 2 h, 4 h and 8 h. Transport stress caused decreases in body weight and increases in serum creatine kinase (CK) activity, nitric oxide (NO) content in heart tissue, cardiac nitric oxide syntheses (NOS) activity and NOS isoforms transcription...
April 20, 2018: Poultry Science
https://www.readbyqxmd.com/read/29733819/mitochondrial-proteome-disruption-in-the-diabetic-heart-through-targeted-epigenetic-regulation-at-the-mitochondrial-heat-shock-protein-70-mthsp70-nuclear-locus
#3
Danielle L Shepherd, Quincy A Hathaway, Cody E Nichols, Andrya J Durr, Mark V Pinti, Kristen M Hughes, Amina Kunovac, Seth M Stine, John M Hollander
>99% of the mitochondrial proteome is nuclear-encoded. The mitochondrion relies on a coordinated multi-complex process for nuclear genome-encoded mitochondrial protein import. Mitochondrial heat shock protein 70 (mtHsp70) is a key component of this process and a central constituent of the protein import motor. Type 2 diabetes mellitus (T2DM) disrupts mitochondrial proteomic signature which is associated with decreased protein import efficiency. The goal of this study was to manipulate the mitochondrial protein import process through targeted restoration of mtHsp70, in an effort to restore proteomic signature and mitochondrial function in the T2DM heart...
May 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29722287/effects-of-enteral-different-dose-levothyroxine-sodium-pretreatment-on-serum-thyroid-hormone-levels-and-myocardial-ischemia-reperfusion-injury
#4
Gui-Zhen Yang, Fu-Shan Xue, Ya-Yang Liu, Hui-Xian Li, Qing Liu, Xu Liao
INTRODUCTION: The available evidence shows that perioperative oral thyroid hormone can significantly attenuate the postoperative decline in the serum hormone level and improve postoperative hemodynamic and prognostic parameters. However, there has been no study assessing the effects of preoperative oral different-dose thyroid hormone on serum hormone levels and myocardial ischemia-reperfusion injury (IRI) after cardiac surgery. METHODS: Forty-eight healthy Wistar rats, aged 35 days, were randomly allocated into six groups: Group BC, Group C and four pretreatment groups in which the rats were given levothyroxine-sodium of 10 μg, 20 μg, 40 μg and 80 μg/100 g...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29675997/hearing-vulnerability-after-noise-exposure-in-a-mouse-model-of-reactive-oxygen-species-overproduction
#5
Shigefumi Morioka, Hirofumi Sakaguchi, Taro Yamaguchi, Yuzuru Ninoyu, Hiroaki Mohri, Takashi Nakamura, Yasuo Hisa, Kiyokazu Ogita, Naoaki Saito, Takehiko Ueyama
Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of ROS overproduction by generating a transgenic (TG) mouse line expressing the human NADPH oxidase 4 (NOX4, NOX4-TG mice), which is a constitutively active ROS-producing enzyme that does not require stimulation or an activator...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29566034/drug-and-or-trauma-induced-hyperthermia-characterization-of-hsp70-and-myoglobin-expression
#6
Benjamin Ondruschka, Franziska Rosinsky, Heiner Trauer, Eckhardt Schneider, Jan Dreßler, Heike Franke
INTRODUCTION: Heat shock protein 70 (HSP70) expression could be discussed as an adaption that promotes repair and counteracts cell damage. Myoglobin is released upon muscle damage of several pathways. The purpose of the present study was to determine whether the expression of HSP70 in kidney, heart and brain and of myoglobin in the kidney were associated with the cause of death and the survival times after lethal intoxications with three of the drugs most widely used in our local area (Saxony, Germany) as well as after fatal traumatic brain injury (TBI)...
2018: PloS One
https://www.readbyqxmd.com/read/29560280/micro-rnas-are-involved-in-activation-of-epicardium-during-zebrafish-heart-regeneration
#7
Marcello Ceci, Claudia Carlantoni, Maria Azzurra Missinato, Davide Bonvissuto, Bruna Di Giacomo, Riccardo Contu, Nicla Romano
Zebrafish could be an interesting translational model to understand and improve the post-infarction trial and possible regeneration in humans. The adult zebrafish is able to regenerate efficiently after resecting nearly 20% of the ventricular apex. This process requires the concert activation of the epicardium and endocardium, as well as trans-differentiation of pre-existing cardiomyocytes that together replace the lost tissue. The molecular mechanisms involved in this activation process are not completely clarified...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29557194/inhibition-of-heat-stress-related-apoptosis-of-chicken-myocardial-cells-through-inducing-hsp90-expression-by-aspirin-administration-in-vivo
#8
Xiaohui Zhang, Miao Zhang, Yanan Su, Zhe Wang, Qiling Zhao, Huaisen Zhu, Zhuang Qian, Jiao Xu, Shu Tang, Di Wu, Ye Lin, Nicole Kemper, Joerg Hartung, Endong Bao
1. This experiment investigated the anti-apoptosis effects and the mechanism of aspirin action in the heat shock response of chicken myocardial cells in vivo, via changes in the heat stress protein Hsp90 and the rate of apoptosis. Broiler chickens were administered aspirin (1 mg/kg body weight) 2 h before exposure to heat stress, and then exposed to 40±1°C for 0, 1, 2, 3, 5, 7, 10, 15 and 24 h. 2. The induction and consumption of the heat stress factor HSF-1, and reductions of HSF-2 and HSF-3 induced by heat stress led to a delay in Hsp90 expression...
March 20, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29556499/-in-silico-analysis-of-differential-gene-expression-in-three-common-rat-models-of-diastolic-dysfunction
#9
Raffaele Altara, Fouad A Zouein, Rita Dias Brandão, Saeed N Bajestani, Alessandro Cataliotti, George W Booz
Standard therapies for heart failure with preserved ejection fraction (HFpEF) have been unsuccessful, demonstrating that the contribution of the underlying diastolic dysfunction pathophysiology differs from that of systolic dysfunction in heart failure and currently is far from being understood. Complicating the investigation of HFpEF is the contribution of several comorbidities. Here, we selected three established rat models of diastolic dysfunction defined by three major risk factors associated with HFpEF and researched their commonalities and differences...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29542021/small-heat-shock-protein-speciation-novel-non-canonical-44-kda-hspb5-related-protein-species-in-rat-and-human-tissues
#10
Rainer Benndorf, Robert R Gilmont, Sahoko Hirano, Richard F Ransom, Peter R Jungblut, Martin Bommer, James E Goldman, Michael J Welsh
When analyzing small stress proteins of rat and human tissues by electrophoretic methods followed by western blotting, and using the anti-HspB1/anti-HspB5 antibody clone 8A7, we unexpectedly found a protein with a molecular mass of ~44 kDa. On two-dimensional gels, this protein resolved into four distinct species. Electrophoretic and immunological evidence suggests that this 44 kDa protein is a derivative of HspB5, most likely a covalently linked HspB5 dimer. This HspB5-like 44 kDa protein (HspB5L-P44) is particularly abundant in rat heart, brain, and renal cortex and glomeruli...
March 14, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29542020/hsp60-expression-profile-under-different-extreme-temperature-stress-in-albino-northern-snakehead-channa-argus
#11
Aiguo Zhou, Shaolin Xie, Zhenlu Wang, Yanfeng Chen, Yue Zhang, Lanfen Fan, Fang Zeng, Jixing Zou
The great albino northern snakehead, Channa argus, is one of the most important economical fish in China. In the present study, cDNA encoding heat shock protein 60 (HSP60) was cloned and characterized. The cDNA was 2462 bp, containing an open reading frame (ORF) encoding a 575-amino-acids polypeptide of 61.10 kDa (theoretical isoelectric point [pI]: 5.66). BLAST analysis showed that AcaHSP60 was highly similar with other HSP60s, and three conserved amino acid blocks and characteristic motifs or domains defined as HSP60 protein family signatures...
March 14, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29482057/grape-seed-proanthocyanidin-reverses-pulmonary-vascular-remodeling-in-monocrotaline-induced-pulmonary-arterial-hypertension-by-down-regulating-hsp70
#12
Fangzheng Chen, Heng Wang, Junjie Yan, Jiadan Lai, Shujing Cai, Linbo Yuan, Situo Zheng
Heat shock protein 70 (HSP70) is a molecular chaperone which has a low content in cytoplasm under normal physiological conditions. A higher intracytoplasmic HSP70 level can be observed in pulmonary arterial smooth muscle cell (PASMC) in pulmonary arterial hypertension (PAH), and this up-regulation can promote pho-IκBα expression, which is an NF-κB signaling pathway inhibitor. NF-κB signaling pathway up-regulation can promote PASMC proliferation and pulmonary vascular remodeling in PAH, resulting in elevation of pulmonary pressure and the subsequent right heart failure caused by right ventricular hypertrophy...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29442224/vitamin-c-and-sodium-bicarbonate-enhance-the-antioxidant-ability-of-h9c2-cells-and-induce-hsps-to-relieve-heat-stress
#13
Bin Yin, Shu Tang, Jiarui Sun, Xiaohui Zhang, Jiao Xu, Liangjiao Di, Zhihong Li, Yurong Hu, Endong Bao
Heat stress is exacerbated by global warming and affects human and animal health, leading to heart damage caused by imbalances in reactive oxygen species (ROS) and the antioxidant system, acid-base chemistry, electrolytes and respiratory alkalosis. Vitamin C scavenges excess ROS, and sodium bicarbonate maintains acid-base and electrolyte balance, and alleviates respiratory alkalosis. Herein, we explored the ability of vitamin C alone and in combination with equimolar sodium bicarbonate (Vitamin C-Na) to stimulate endogenous antioxidants and heat shock proteins (HSPs) to relieve heat stress in H9C2 cells...
February 13, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29409895/bcl-2-associated-athanogene-3-bag3-is-an-enhancer-of-small-heat-shock-protein-turnover-via-activation-of-autophagy-in-the-heart
#14
Yui Inomata, Shouta Nagasaka, Kazuki Miyate, Yuta Goto, Chizuru Hino, Chihiro Toukairin, Rieko Higashio, Kinji Ishida, Tomoyuki Saino, Masamichi Hirose, Hideki Tsumura, Atsushi Sanbe
Bcl-2-associated athanogene 3 (BAG3) is strongly expressed in both cardiac and skeletal muscle. A recent study showed that BAG3 may play a protective role in muscles. Little is known, however, regarding the detailed role of BAG3 in cardiac muscle. To better understand the functional role of cardiac BAG3 in the heart, we generated transgenic (TG) mice that overexpress BAG3. A decrease in fractional shortening, and the induction of cardiac atrial natriuretic peptide, were observed in BAG3 TG mice. Moreover, a marked reduction in the protein level of small HSPs was detected in BAG3 TG mouse hearts...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29394239/matrine-protects-cardiomyocytes-from-ischemia-reperfusion-injury-by-regulating-hsp70-expression-via-activation-of-the-jak2-stat3-pathway
#15
Suping Guo, Chuanyu Gao, Wentao Xiao, Jing Zhang, Yongsheng Qu, Jiang Li, Famin Ye
Studies have shown that matrine showed cardiovascular protective effects; however, its role and mechanism in myocardial ischemia/reperfusion (I/R) injury remain unknown. The Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway activation and elevated heat shock protein (HSP) 70 are closely related to the prevention of myocardial I/R injury. The cardioprotective effects of matrine were determined in hypoxia/reoxygenation (H/R) treated primary rat cardiomyocytes and left anterior descending coronary artery ligation and reperfusion animal models...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29383398/methamphetamine-withdrawal-induces-activation-of-crf-neurons-in-the-brain-stress-system-in-parallel-with-an-increased-activity-of-cardiac-sympathetic-pathways
#16
Juan Antonio García-Carmona, Polymnia Georgiou, Panos Zanos, Alexis Bailey, Maria Luisa Laorden
Methamphetamine (METH) addiction is a major public health problem in some countries. There is evidence to suggest that METH use is associated with increased risk of developing cardiovascular problems. Here, we investigated the effects of chronic METH administration and withdrawal on the activation of the brain stress system and cardiac sympathetic pathways. Mice were treated with METH (2 mg/kg, i.p.) for 10 days and left to spontaneous withdraw for 7 days. The number of corticotrophin-releasing factor (CRF), c-Fos, and CRF/c-Fos neurons was measured by immunohistochemistry in the paraventricular nucleus of the hypothalamus (PVN) and the oval region of the bed nucleus of stria terminalis (ovBNST), two regions associated with cardiac sympathetic control...
April 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29351515/understanding-key-mechanisms-of-exercise-induced-cardiac-protection-to-mitigate-disease-current-knowledge-and-emerging-concepts
#17
Bianca C Bernardo, Jenny Y Y Ooi, Kate L Weeks, Natalie L Patterson, Julie R McMullen
The benefits of exercise on the heart are well recognized, and clinical studies have demonstrated that exercise is an intervention that can improve cardiac function in heart failure patients. This has led to significant research into understanding the key mechanisms responsible for exercise-induced cardiac protection. Here, we summarize molecular mechanisms that regulate exercise-induced cardiac myocyte growth and proliferation. We discuss in detail the effects of exercise on other cardiac cells, organelles, and systems that have received less or little attention and require further investigation...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29319584/physiological-responses-to-overdressing-and-exercise-heat-stress-in-trained-runners
#18
Brett R Ely, Laurie A Blanchard, Jared R Steele, Michael A Francisco, Samuel N Cheuvront, Christopher T Minson
Heat acclimation is the best strategy to improve performance in a hot environment. Many athletes seeking the benefits of heat acclimation lack access to a hot environment for exercise, and thus rely on over-dressing to simulate environmental heat stress. It is currently unknown whether this approach produces the requisite thermoregulatory strain necessary for heat acclimation in trained men and women. PURPOSE: To compare physiological and cellular responses to exercise in a hot environment (HOT; 40°C, 30%rh) with minimal clothing (clo= 0...
January 9, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29306763/hsp60-and-hsp90%C3%AE-from-blunt-snout-bream-megalobrama-amblycephala-molecular-cloning-characterization-and-comparative-response-to-intermittent-thermal-stress-and-aeromonas-hydrophila-infection
#19
Changyou Song, Yanting Cui, Bo Liu, Jun Xie, Xianping Ge, Pao Xu, Mingchun Ren, Linghong Miao, Qunlan Zhou, Yan Lin
Heat shock proteins (HSPs) play critical roles in the process of anti-stress and immunity and are implicated in autoimmune diseases. In order to understand the comparative stress responses of HSP60 and HSP90β under intermittent thermal stress and Aeromonas hydrophila infection, we cloned their full-length cDNAs from Megalobrama amblycephala liver, predicted their secondary and tertiary structure, and examined their tissue-specific expression patterns. The full length of HSP60 and HSP90β cDNAs indicated that they included all signature sequences of corresponding protein families...
March 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29303599/proteomic-analysis-of-peroxynitrite-induced-protein-nitration-in-isolated-beef-heart-mitochondria
#20
M Kohutiar, A Eckhardt, I Mikšík, P Šantorová, J Wilhelm
Mitochondria are exposed to reactive nitrogen species under physiological conditions and even more under several pathologic states. In order to reveal the mechanism of these processes we studied the effects of peroxynitrite on isolated beef heart mitochondria in vitro. Peroxynitrite has the potential to nitrate protein tyrosine moieties, break the peptide bond, and eventually release the membrane proteins into the solution. All these effects were found in our experiments. Mitochondrial proteins were resolved by 2D electrophoresis and the protein nitration was detected by immunochemical methods and by nano LC-MS/MS...
January 5, 2018: Physiological Research
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