keyword
https://read.qxmd.com/read/38485068/a-systematic-review-of-online-resources-for-the-dietary-management-of-hyperphosphatemia-in-people-with-chronic-kidney-disease
#1
JOURNAL ARTICLE
Most Murshida Begum, Annabel Biruete, Brandon Kistler, Anthony Meade, John Westhoff, David E St-Jules
OBJECTIVE: Internet search engines and social media websites are prominent and growing sources of dietary information for people with chronic kidney disease (CKD) and their healthcare providers. However, nutrition therapy for CKD is undergoing a paradigm shift, which may lead to inconsistent advice for managing hyperphosphatemia. The aim of this study was to summarize and evaluate online resources for phosphorus-specific nutrition therapy. DESIGN AND METHODS: Patient-facing resources were collected from Google, Yahoo, and Facebook in June-July 2021...
March 12, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38485067/dietary-phosphate-educational-materials-for-pediatric-chronic-kidney-disease-are-confused-messages-reducing-their-impact
#2
JOURNAL ARTICLE
Louise McAlister, Vanessa Shaw, Rukshana Shroff
OBJECTIVE: This study aimed to review the quality and content of phosphate educational materials used in pediatric chronic kidney disease. METHODS: The quality of text-based pediatric phosphate educational materials was assessed using validated instruments for health literacy demands (Suitability Assessment of Materials [SAM] and Patient Education Material Assessment Tool [PEMAT-P]) and readability (Flesch Reading Ease [FRE] and Flesch-Kincaid [FK] Grade Level)...
March 12, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38473817/inorganic-phosphate-induced-extracellular-vesicles-from-vascular-smooth-muscle-cells-contain-elevated-levels-of-hyaluronic-acid-which-enhance-their-interaction-with-very-small-superparamagnetic-iron-oxide-particles
#3
JOURNAL ARTICLE
Christian Freise, Karina Biskup, Véronique Blanchard, Jörg Schnorr, Matthias Taupitz
Patients with chronic kidney disease (CKD) have a high prevalence of hyperphosphatemia, where uremic toxins like inorganic phosphate (Pi) induce a cardiovascular remodeling. Related disorders like atherosclerosis bear the risk of increased morbidity and mortality. We previously found that Pi stimulates the synthesis and sulfation of the negatively charged glycosaminoglycans (GAGs) heparan sulfate and chondroitin sulfate in vascular smooth muscle cells (VSMC). Similar GAG alterations were detected in VSMC-derived exosome-like extracellular vesicles (EV)...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38453435/efficacy-tolerability-and-safety-of-the-oral-phosphate-binder-vs-505-ap301
#4
JOURNAL ARTICLE
Bing Zhuang, Liangying Gan, Bin Liu, Weijie Yuan, Ming Shi, Ai Peng, Lihua Wang, Xiaolan Chen, Tongqiang Liu, Shiying Zhang, Song Wang, Qing Gao, Baoxing Wang, Huixiao Zheng, Changhua Liu, Yuan Luo, Hong Ye, Hongli Lin, Yiwen Li, Qiang He, Feng Zheng, Ping Luo, Gang Long, Wei Lu, Kanghui Li, Junwei Yang, Yingxue Cathy Liu, Zhizheng Zhang, Xiaolin Li, Weifeng Zhang, Li Zuo
BACKGROUND: VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part phase 2 study evaluated the tolerability, safety, and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD). METHODS: In Part 1, patients received dose-escalated treatment with VS-505 2.25, 4.50, and 9.00 g/day for 2 weeks each, guided by serum phosphorus levels...
March 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38453265/mediterranean-diet-for-cardiovascular-risk-reduction-in-chronic-kidney-disease
#5
REVIEW
Hugo Bakis, Philippe Chauveau, Christian Combe, Pierre Pfirmann
The Mediterranean diet is a plant-based healthy diet similar to the vegetarian and the Dietary Approaches to Stop Hypertension diets. Unlike vegetarian and Dietary Approaches to Stop Hypertension diets, the Mediterranean diet encourages a lifestyle associated with physical activity, and social connections. In addition, the Mediterranean diet is not based on restriction of nutrients but does limit intake of processed foods. Prospective studies have confirmed that the Mediterranean diet confers primary and secondary cardiovascular disease prevention in the general population...
November 2023: Adv Kidney Dis Health
https://read.qxmd.com/read/38448815/relationship-between-serum-phosphorus-and-mortality-in-non-dialysis-chronic-kidney-disease-patients-evidence-from-nhanes-2001-2018
#6
JOURNAL ARTICLE
Zhongcheng Fan, Rugang Li, Miaoxia Pan, Yangyang Jiang, Ying Li, Li Liu, Yang Li
BACKGROUND: Hyperphosphatemia is common in chronic kidney disease (CKD), associated with higher mortality in dialysis patients. Its impact in non-dialysis patients, especially those with preserved kidney function, remains uncertain. METHODS: A prospective cohort study was conducted using data from the National Health and Nutrition Examination Survey (2001-2008). Serum phosphorus was analyzed as a continuous variable, or categorized into three groups: < 3...
March 6, 2024: BMC Nephrology
https://read.qxmd.com/read/38418258/seeing-the-whole-picture-evaluating-the-contribution-of-whole-grains-to-phosphorus-exposure-in-people-with-kidney-failure-undergoing-dialysis-treatment
#7
REVIEW
Dillon Winkelman, Kathleen Hill Gallant, Sharon Moe, David E St-Jules
Excessive dietary phosphorus is a concern among patients with kidney failure undergoing dialysis treatment because it may contribute to hyperparathyroidism and hyperphosphatemia. A long-standing but untested component of the low-phosphorus diet is the promotion of refined grains over whole grains. This paper reviews the scientific premise for restricting whole grains in the dialysis population and estimates phosphorus exposure from grain products based on three grain intake patterns modeled from reported intakes in the general US population, adjusting for the presence of phosphorus additives and phosphorus bioavailability: (1) standard grain intake, (2) 100% refined grain intake, and (3) mixed (50/50 whole and refined grain) intake...
February 28, 2024: Seminars in Dialysis
https://read.qxmd.com/read/38412277/tenapanor-xphozah-for-hyperphosphatemia-in-chronic-kidney-disease
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 4, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38397979/the-efficacy-and-safety-of-high-dose-cholecalciferol-therapy-in-hemodialysis-patients
#9
JOURNAL ARTICLE
Agnieszka Tarasewicz, Michał Komorniczak, Agnieszka Zakrzewska, Bogdan Biedunkiewicz, Sylwia Małgorzewicz, Magdalena Jankowska, Katarzyna Jasiulewicz, Natalia Płonka, Małgorzata Dąbrowska, Alicja Dębska-Ślizień, Leszek Tylicki
Vitamin D deficiency and insufficiency are highly prevalent in CKD, affecting over 80% of hemodialysis (HD) patients and requiring therapeutic intervention. Nephrological societies suggest the administration of cholecalciferol according to the guidelines for the general population. The aim of the observational study was to evaluate the efficacy and safety of the therapy with a high dose of cholecalciferol in HD patients with 25(OH)D deficiency and insufficiency to reach the target serum 25(OH)D level > 30 ng/mL...
February 6, 2024: Biomedicines
https://read.qxmd.com/read/38392329/vascular-calcification-a-passive-process-that-requires-active-inhibition
#10
REVIEW
Ricardo Villa-Bellosta
The primary cause of worldwide mortality and morbidity stems from complications in the cardiovascular system resulting from accelerated atherosclerosis and arterial stiffening. Frequently, both pathologies are associated with the pathological calcification of cardiovascular structures, present in areas such as cardiac valves or blood vessels (vascular calcification). The accumulation of hydroxyapatite, the predominant form of calcium phosphate crystals, is a distinctive feature of vascular calcification. This phenomenon is commonly observed as a result of aging and is also linked to various diseases such as diabetes, chronic kidney disease, and several genetic disorders...
February 9, 2024: Biology
https://read.qxmd.com/read/38385423/a-rare-reason-for-severe-hypocalcemia-following-kidney-transplant-denosumab-treatment
#11
Muride Aktas, Hayriye Nur Oray Unlu, Murat Karatas, Gokalp Okut, Berna Eren, Adam Uslu, Erhan Tatar
Deviations of calcium, phosphate, parathyroid hormone, and vitamin D levels are the basis for the diagnosis of calcium-phosphate metabolism disorders. The plasma concentration of the biologically active form known as free calcium is regulated in a harmonious manner by its exchange in the bones and reabsorption by the kidneys. These steps take place under the control of parathyroid hormone and calcitriol. In the process of chronic kidney disease, the kidney cannot synthesize adequate calcitriol, and the resulting hypocalcemia and hyperphosphatemia cause the development of secondary hyperparathyroidism...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38376758/cost-effectiveness-and-clinical-outcomes-of-secondary-hyperparathyroidism-treatments-in-patients-with-chronic-kidney-disease
#12
JOURNAL ARTICLE
Wenjie Zhang, Hailiang Ren, Qianxiu Liao, Jian Wu
The study addresses the challenge of treating secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, focusing on the cost-effectiveness of surgical versus pharmacological interventions. Conducting a retrospective analysis on 152 CKD patients with SHPT at the Third People's Hospital of Chengdu, the study matched 80 patients into two groups: 40 undergoing parathyroidectomy with autotransplantation (PTX + AT) and 40 treated with calcimimetics. PTX + AT was more effective in alleviating symptoms, particularly bodily pain, and demonstrated greater cost-effectiveness over a long-term period compared to calcimimetics...
February 20, 2024: Calcified Tissue International
https://read.qxmd.com/read/38317140/machine-learning-based-biomarker-discovery-for-chronic-kidney-disease-mineral-and-bone-disorder-ckd-mbd
#13
JOURNAL ARTICLE
Yuting Li, Yukuan Lou, Man Liu, Siyi Chen, Peng Tan, Xiang Li, Huaixin Sun, Weixin Kong, Suhua Zhang, Xiang Shao
INTRODUCTION: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and some other complications. Although there are diagnostic criteria for CKD-MBD, in situations when conducting target feature examining are unavailable, there is a need to investigate and discover alternative biochemical criteria that are easy to obtain. Moreover, studying the correlations between the newly discovered biomarkers and the existing ones may provide insights into the underlying molecular mechanisms of CKD-MBD...
February 5, 2024: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/38277356/effect-of-an-nhe3-inhibitor-in-combination-with-an-npt2b-inhibitor-on-gastrointestinal-phosphate-absorption-in-rodent-models
#14
JOURNAL ARTICLE
Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A Reidy, Joseph V Haas, Yanping Xu, Mark C Kowala, Prabhakar K Jadhav, John R Wetterau
Many of the pathological consequences of chronic kidney disease can be attributed to an elevation in serum phosphate levels. Current therapies focused on decreasing intestinal phosphate absorption to treat hyperphosphatemia are inadequate. The most effective therapeutic strategy may be to target multiple absorptive pathways. In this study, the ability of a novel inhibitor of the intestinal sodium hydrogen exchanger 3 (NHE3), LY3304000, which inhibits paracellular, diffusional uptake of phosphate, to work in combination with an inhibitor of the active transporter, sodium dependent phosphate cotransporter 2b (NPT2b), LY3358966, was explored...
2024: PloS One
https://read.qxmd.com/read/38275129/excess-phosphate-promotes-sars%C3%A2-cov%C3%A2-2-n-protein%C3%A2-induced-nlrp3-inflammasome-activation-via-the-scap%C3%A2-srebp2-signaling-pathway
#15
JOURNAL ARTICLE
Mi-Hua Liu, Xiao-Long Lin, Le-Le Xiao
Hyperphosphatemia or severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can promote cardiovascular adverse events in patients with chronic kidney disease. Hyperphosphatemia is associated with elevated inflammation and sterol regulatory element binding protein 2 (SREBP2) activation, but the underlying mechanisms in SARS‑CoV‑2 that are related to cardiovascular disease remain unclear. The present study aimed to elucidate the role of excess inorganic phosphate (PI) in SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation and the underlying mechanisms in vascular smooth muscle cells (VSMCs)...
March 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38234299/elevated-luminal-inorganic-phosphate-suppresses-intestinal-zn-absorption-in-5-6-nephrectomized-rats
#16
JOURNAL ARTICLE
Yosuke Okumura, Kotaro Abe, Shoko Sakai, Yuki Kamei, Yuki Mori, Yuichiro Adachi, Masaki Takikawa, Ayano Kitamura, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Taiho Kambe, Hironori Yamamoto, Yutaka Taketani
Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is often impaired; however, the mechanism underlying Zn malabsorption remains unclear. Here, we evaluated intestinal Zn absorption capacity in a rat model of CKD induced by 5/6 nephrectomy (5/6 Nx). Rats were given Zn and the incremental area under the plasma Zn concentration-time curve (iAUC) was measured, as well as expression of ZIP4, an intestinal Zn transporter...
January 18, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38205639/phosphate-in-cardiovascular-disease-from-new-insights-into-molecular-mechanisms-to-clinical-implications
#17
REVIEW
Mandy E Turner, Laurent Beck, Kathleen M Hill Gallant, Yabing Chen, Orson W Moe, Makoto Kuro-O, Sharon M Moe, Elena Aikawa
Hyperphosphatemia is a common feature in patients with impaired kidney function and is associated with increased risk of cardiovascular disease. This phenomenon extends to the general population, whereby elevations of serum phosphate within the normal range increase risk; however, the mechanism by which this occurs is multifaceted, and many aspects are poorly understood. Less than 1% of total body phosphate is found in the circulation and extracellular space, and its regulation involves multiple organ cross talk and hormones to coordinate absorption from the small intestine and excretion by the kidneys...
March 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38180904/phosphonoformic-acid-reduces-hyperphosphatemia-induced-vascular-calcification-via-pit-1
#18
JOURNAL ARTICLE
Hualong Zang, Yang Liu, Qiuping Teng, Jiao Hua, Dan Peng, Ping Wang
OBJECTIVE: This study aimed to examine the mechanism of hyperphosphatemia-induced vascular calcification (HPVC). METHODS: Primary human aortic smooth muscle cells and rat aortic rings were cultured in Dulbecco's modified Eagle's medium supplemented with 0.9 mM or 2.5 mM phosphorus concentrations. Type III sodium-dependent phosphate cotransporter-1 (Pit-1) small interfering RNA and phosphonoformic acid (PFA), a Pit-1 inhibitor, were used to investigate the effects and mechanisms of Pit-1 on HPVC...
January 2024: Journal of International Medical Research
https://read.qxmd.com/read/38175251/effects-of-a-single-phosphate-enriched-test-meal-on-inflammasome-activity-and-postprandial-inflammatory-markers-in-healthy-subjects
#19
JOURNAL ARTICLE
Anika Nier, Christof Ulrich, Christin Volk, Marie-Charlotte Wolffgang, Corinna Brandsch, Monika Wensch-Dorendorf, Matthias Girndt, Gabriele I Stangl
PURPOSE: The consumption of highly processed food is often associated with a high intake of inorganic phosphate. Hyperphosphatemia is accompanied by an inflammatory status in patients with chronic kidney disease. However, the immune response to high phosphorus intake in healthy individuals is largely unknown. Therefore, the aim of the present study was to evaluate the effect of a single phosphate-enriched meal on inflammasome activity and plasma levels of inflammatory markers. METHODS: The analysis included 28 participants who received a single dose of either 700 mg phosphorus or a placebo with a test meal...
January 4, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38172460/a-therapeutic-approach-in-the-management-of-chronic-kidney-disease-plant-based-dietary-models-and-associated-parameters
#20
REVIEW
Kezban Sahin, Hilal Yıldıran
PURPOSE OF REVIEW: Chronic kidney disease is one of the leading causes of death worldwide today. Nutrition and nutrition-related factors have a very important role in both the prevention and management of the disease. Plant-based dietary practices are one of the promising approaches to chronic kidney disease. This review aims to examine the potential benefits and risks of plant-based diet models on symptoms and indices used in diet quality in chronic kidney disease. RECENT FINDINGS: Recently, a growing body of evidence has shown that, unlike animal-based diets, diets rich in plant-based nutrients may play an active role in the incidence of chronic kidney disease in many ways and the management of common symptoms, such as metabolic acidosis, uremic toxicity, and hyperphosphatemia...
January 3, 2024: Current Nutrition Reports
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