keyword
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#1
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38534927/high-symptom-burden-in-patients-receiving-radiotherapy-and-factors-associated-with-being-offered-an-intervention
#2
JOURNAL ARTICLE
Allison Rau, Demetra Yannitsos, Petra Grendarova, Siwei Qi, Linda Watson, Lisa Barbera
Patient report outcomes are commonly collected during oncology visits to elicit symptom burden and guide management. We aimed to determine the frequency of intervention for patients undergoing radiotherapy with high symptom complexity scores and identify which factors are associated with being offered an intervention. A retrospective chart audit was completed of adult patients with cancer who had at least one radiotherapy appointment and were assigned a high symptom complexity. A total of 200 patients were included; 150 (75...
February 27, 2024: Current Oncology
https://read.qxmd.com/read/38531242/evaluation-of-188-re-iba-as-a-novel-radiopharmaceutical-for-bone-marrow-ablation
#3
JOURNAL ARTICLE
Hassan Ranjbar, Reza Bagheri, Seyed-Milad Miremad
In this study, Ibandronate as a third generation of bisphosphonates was labeled with rhenium-188 radionuclide. Production and quality control of 188 Re-IBA radiopharmaceutical was investigated. The radiation absorbed dose of this radiopharmaceutical was evaluated for adult male based on biodistribution data in mice using the RADAR and Sparks and Aydogan methodologies. The 188 Re-IBA was produced with more than 96% radiochemical purity. The highest value of %ID/g was related to bone with 7.11% at 12 h post-injection...
March 24, 2024: Applied Radiation and Isotopes
https://read.qxmd.com/read/38529676/significance-of-hiv-status-in-cervical-cancer-patients-receiving-curative-chemoradiation-therapy-definitive-radiation-alone-or-palliative-radiation-in-botswana
#4
JOURNAL ARTICLE
Kinza Meghani, Priya Puri, Lisa Bazzett-Matabele, Peter Vuylsteke, Rebecca Luckett, Barati Monare, Sebathu Chiyapo, Rebecca Ketlametswe, Tlotlo B Ralefala, Memory Bvochora-Nsingo, Nicola Zetola, Doreen Ramogola-Masire, Surbhi Grover
BACKGROUND: Cervical cancer associated with human papillomavirus has the highest cancer incidence and mortality for women in Botswana because of a high HIV prevalence and limited screening. This study investigates the significance of HIV on the overall survival (OS) of patients with locally advanced cervical cancer by various treatment categories (curative chemoradiation, definitive radiation [RT] alone, or palliative RT alone). METHODS: This study included patients diagnosed with cervical cancer between 2013 and 2020, prospectively enrolled in the Botswana Prospective Cancer Cohort...
March 26, 2024: Cancer
https://read.qxmd.com/read/38528774/are-oral-cancers-effectively-palliated-with-radiotherapy-outcomes-of-treatment-with-a-modified-quad-shot-regimen
#5
JOURNAL ARTICLE
Saheli Saha, Indranil Mallick, Prattusha Mukherjee, Santam Chakraborty, Tapesh Bhattacharyya, Moses Arunsingh S, Rimpa Basu Achari, Sanjoy Chatterjee
BACKGROUND: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. METHODS: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer...
March 25, 2024: Head & Neck
https://read.qxmd.com/read/38525523/numerous-multinucleated-giant-cells-in-cutaneous-epithelioid-angiosarcoma-and-pulmonary-metastasis-a-unique-observation-with-potential-diagnostic-pitfalls
#6
Yushi Kanatani, Yasuhiro Mitsui, Kohei Ogawa, Maiko Takeda, Fumi Miyagawa, Satoru Shinkuma, Takeshi Kawaguchi, Takaya Fukumoto, Hideo Asada
The histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79-year-old man presented with a red-purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2-40, and ERG...
March 25, 2024: Journal of Cutaneous Pathology
https://read.qxmd.com/read/38523960/variation-in-access-to-palliative-radiotherapy-in-prostate-cancer-a-population-based-study-in-canada
#7
JOURNAL ARTICLE
Alborz Jooya, Daniel Qureshi, William J Phillips, Jennifer Leigh, Colleen Webber, Ajay Aggarwal, Peter Tanuseputro, Scott Morgan, Robert Macrae, Michael Ong, Jean-Marc Bourque
BACKGROUND: As a result of improvements in cancer therapies, patients with metastatic malignancies are living longer, and the role of palliative radiotherapy has become increasingly recognized. However, access to adequate palliative radiotherapy may continue to be a challenge, as is evident from the high proportion of patients dying of prostate cancer who never receive palliative radiotherapy. The main objective of this investigation is to identify and describe the factors associated with the receipt of palliative radiation treatment in a decedent cohort of prostate cancer patients in Ontario...
February 2024: Curēus
https://read.qxmd.com/read/38518555/radiation-therapy-oncology-group-8502-quad-shot-regimen-using-volumetric-modulated-arc-therapy-for-incurable-head-and-neck-cancer
#8
JOURNAL ARTICLE
Ryo Toya, Yoshiyuki Fukugawa, Tetsuo Saito, Tomohiko Matsuyama, Ryoji Yoshida, Daizo Murakami, Yorihisa Orita, Hideki Nakayama, Natsuo Oya
OBJECTIVES: We aimed to evaluate the outcomes of the Radiation Therapy Oncology Group 8502 "QUAD shot" regimen using volumetric modulated arc therapy (VMAT) for incurable head and neck cancer (HNC). MATERIALS AND METHODS: We included 105 patients with HNC in the study, undergoing at least one QUAD shot regimen cycle. We planned the radiotherapy using VMAT with 6 MV photons. One QUAD shot cycle included 14.8 Gy in 4 fractions with at least 6-hour intervals over 2 consecutive days, repeated every 3-6 weeks up to 3 cycles...
March 21, 2024: Oral Oncology
https://read.qxmd.com/read/38517592/en%C3%A2-bloc-groin-node-resection-reconstructed-with-external-oblique-flap-for-solitary-metastatic-cholangiocarcinoma-a-case-report
#9
JOURNAL ARTICLE
Chalisa Suwanprinya, Vor Luvira, Kengkart Winaikosol, Palakorn Surakunprapha, Pattama Punyavong, Kamonwan Jenwitheesuk, Ake Pugkhem, Chawalit Pairojkul
Cholangiocarcinoma requires complete surgical resection for cure. Even so, the recurrence and metastasis rates are high, and further treatment is typically through palliative systemic chemotherapy. Curative-intent resection of metastatic site may provide survival benefit in selected cases. However, there were no previous reports of groin node dissection in cholangiocarcinoma. We have reported the first case of intrahepatic mass-forming cholangiocarcinoma with isolated synchronous groin node metastasis, successfully treated with   resection of the liver mass followed by groin node resection, reconstructed with musculofascial flap...
March 22, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38509654/reirradiation-of-metastases-of-the-central-nervous-system-part-1-brain-metastasis
#10
JOURNAL ARTICLE
Dirk Rades, Charles B Simone, Henry C Y Wong, Edward Chow, Shing Fung Lee, Peter A S Johnstone
Because of improved survival of cancer patients, more patients irradiated for brain metastases develop intracerebral recurrences requiring subsequent courses of radiotherapy. Five studies focused on reirradiation with whole-brain radiation therapy (WBRT) after initial WBRT for brain metastases. Following the second WBRT course, improvement of clinical symptoms was found in 31-68% of patients. Rates of neurotoxicity, such as encephalopathy or cognitive decline, were reported in two studies (1.4% and 32%). In another study, severe or unexpected adverse events were not observed...
March 20, 2024: Annals of Palliative Medicine
https://read.qxmd.com/read/38502353/piloting-a-language-translation-device-for-mandarin-speaking-patients-presenting-for-radiotherapy-treatment-assessing-patient-and-radiation-therapist-perspectives
#11
JOURNAL ARTICLE
Darren Hunter, Nigel Anderson, Richard Oates, David Kok, Daniel Sapkaroski, Nicola Treffry, Caroline Wright
PURPOSE: Culturally and linguistically diverse (CALD) cancer patients report unmet informational and emotional needs when receiving radiotherapy (RT). This feasibility study aimed to evaluate the clinical use of an instant translation device (ITD) to facilitate communication between Mandarin-speaking patients and radiation therapists (RTTs) within the Australian public RT setting. The primary aim was to assess the ability to convey information relating to daily patient care and build rapport using the device...
March 19, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38501155/primary-thoracic-aorta-angiosarcoma-presenting-with-thromboembolism-and-progressive-claudication-despite-anticoagulation
#12
Jane McKenzie, Sarat Chander, Catherine Mitchell, Jeremy Lewin
Primary aortic angiosarcomas (PAA) are rare angiosarcomas, frequently diagnosed in advanced stages due to initial misdiagnosis. This case describes a 66-year-old woman, initially presenting with a distal thoracic aorta thrombus and symptomatic bilateral popliteal emboli. Despite initial management and therapeutic anticoagulation, she experienced progressive lower limb claudication and 12 months following initial presentation she re-presented with an obstructing distal thoracic aorta mass and metastatic disease...
March 19, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38500454/utility-of-30-day-mortality-as-a-quality-metric-for-palliative-radiation-treatment-a-population-based-analysis-from-queensland-australia
#13
JOURNAL ARTICLE
Tracey L Guan, Justin H Kutzko, Dominic P Lunn, Nathan Am Dunn, Bryan H Burmeister, Parvati Dadwal, Nancy Tran, Tanya R Holt
INTRODUCTION: Palliative radiotherapy (PRT) is frequently used to treat symptoms of advanced cancer, however benefits are questionable when life expectancy is limited. The 30-day mortality rate after PRT is a potential quality indicator, and results from a recent meta-analysis suggest a benchmark of 16% as an upper limit. In this population-based study from Queensland, Australia, we examined 30-day mortality rates following PRT and factors associated with decreased life expectancy. METHODS: Retrospective population data from Queensland Oncology Repository was used...
March 19, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38493900/classification-of-patients-with-painful-tumors-to-predict-the-response-to-palliative-radiotherapy
#14
JOURNAL ARTICLE
Yutaro Koide, Yurika Shindo, Naoya Nagai, Tomoki Kitagawa, Takahiro Aoyama, Hidetoshi Shimizu, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira
PURPOSE: This study aimed to identify factors affecting pain response to develop a patient classification system for palliative radiotherapy. METHODS AND MATERIALS: Our prospective observational study (XXXXX) provided data on patients who received palliative radiotherapy for painful tumors. The eligibility criteria were that the numerical rating scale (NRS) was 2 or more before treatment, and palliative radiotherapy was performed between August 2021 and September 2022...
March 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38490228/systematic-endoscopic-staging-of-mediastinum-to-guide-radiotherapy-planning-in-patients-with-locally-advanced-non-small-cell-lung-cancer-seismic-an-international-multicentre-single-arm-clinical-trial
#15
JOURNAL ARTICLE
Daniel P Steinfort, Gargi Kothari, Neil Wallace, Nicholas Hardcastle, Kanishka Rangamuwa, Edith M T Dieleman, Percy Lee, Peixuan Li, Julie A Simpson, Shaun Yo, Farzad Bashirdazeh, Phan Nguyen, Barton R Jennings, David Fielding, Laurence Crombag, Louis B Irving, Kazuhiro Yasufuku, Jouke T Annema, David E Ost, Shankar Siva
BACKGROUND: Systematic mediastinal lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) improves accuracy of staging in patients with early-stage non-small-cell lung cancer (NSCLC). However, patients with locally advanced NSCLC commonly undergo only selective lymph node sampling. This study aimed to determine the proportion of patients with locally advanced NSCLC in whom systematic endoscopic mediastinal staging identified PET-occult lymph node metastases, and to describe the consequences of PET-occult disease on radiotherapy planning...
March 11, 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/38489819/therapeutic-approaches-for-spinal-synovial-sarcoma-a-comprehensive-review-of-the-literature
#16
JOURNAL ARTICLE
Aroosa Zamarud, Syeda Shahnoor, Adeena Maryyum, Abdul Moiz Khan, Khawaja Muthammir Hassan, Aamna Ijaz, Rahman Sayed, Kelly Yoo, David J Park, Steven D Chang
OBJECTIVE: Synovial sarcoma (SS) is a relatively rare type of soft-tissue sarcoma that is commonly treated with surgery, radiation, chemotherapy, and palliative care. Stereotactic radiosurgery (SRS) is an emerging approach that shows promise in treating CNS conditions, but it has not been studied for SS. The authors present a systematic review that explores the effectiveness of different treatments, with a focus on SRS, for managing spinal SS. METHODS: A systematic PubMed search was conducted that covered studies from 1964 to 2022, yielding 70 relevant studies...
March 15, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38488881/stereotactic-body-radiotherapy-for-distant-metastases-to-the-head-and-neck
#17
JOURNAL ARTICLE
Adam Mutsaers, Ahmed Abugharib, Ian Poon, Joshua Loblaw, Andrew Bayley, Liying Zhang, Lee Chin, Madette Galapin, Darby Erler, Arjun Sahgal, Kevin Higgins, Danny Enepekides, Antoine Eskander, Irene Karam
PURPOSE: To report clinical outcomes for patients with metastatic disease to the head and neck (HN) treated with stereotactic body radiation therapy (SBRT). METHODS: A retrospective review of patients treated with SBRT to HN sites from 2012 to 2020 was conducted. Treatment indications included the following: oligometastases, oligoprogression, and control a dominant area of progression (DAP). Kaplan-Meier method was used to estimate local control (LC), regional control (RC), overall survival (OS), and progression-free survival (PFS)...
March 15, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38488793/bone-modifying-agents-in-patients-with-high-risk-metastatic-castration-sensitive-prostate-cancer-treated-with-abiraterone-acetate
#18
JOURNAL ARTICLE
Wataru Fukuokaya, Keiichiro Mori, Fumihiko Urabe, Taro Igarashi, Takafumi Yanagisawa, Shunsuke Tsuzuki, Mariko Honda, Kenta Miki, Takahiro Kimura
IMPORTANCE: The association between the use of bone-modifying agents (BMAs) and the outcomes among patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with abiraterone acetate plus prednisone (AAP) remains unclear. OBJECTIVE: To investigate the association between BMA use and the outcomes of patients with mCSPC receiving AAP. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, a post hoc analysis of individual participant data from the LATITUDE trial was performed...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38481587/chordoma-of-the-oropharynx
#19
Almedina Ramas, Merima Kasumovic, Sabrina Uscupsic, Majda Mujic, Lejla Tokic
BACKGROUND: Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of "NOS" chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient. According to contemporary research, chordoma is a rare malignant neoplasm that arises from the embryonic remnants of the notochord. and typically involves the clivus, sacrococcygeal bones or vertebrae...
2024: Medical Archives
https://read.qxmd.com/read/38476609/metastatic-gallbladder-cancer-presenting-as-numb-chin-syndrome-a-case-report-and-literature-review
#20
Makoto Murahashi, Edward Hosea Ntege, Kentaro Ide, Nobuyuki Maruyama, Jumpei Shirakawa, Hiroki Koyama, Toshihiro Kawano, Takahiro Goto, Yusuke Shimizu, Kazuhide Nishihara, Hiroyuki Nakamura
Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months...
April 2024: Biomedical Reports
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