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Palliative radiation

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https://www.readbyqxmd.com/read/29165794/leptomeningeal-metastasis-from-systemic-cancer-review-and-update-on-management
#1
REVIEW
Nancy Wang, Mia S Bertalan, Priscilla K Brastianos
Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a poor prognosis and limited treatment options. Diagnosis is often challenging, with nonspecific presenting symptoms ranging from headache and confusion to focal neurologic deficits, such as cranial nerve palsies. Standard diagnostic evaluation involves a neurologic examination, magnetic resonance imaging of the brain and spine with gadolinium, and cytologic evaluation of the cerebral spinal fluid. Therapy entails a multimodal approach focused on palliation with surgery, radiation, and/or chemotherapy, which may be administered systemically or directly into the cerebral spinal fluid...
November 22, 2017: Cancer
https://www.readbyqxmd.com/read/29156912/genetic-biomarkers-associated-with-pain-flare-and-dexamethasone-response-following-palliative-radiotherapy-in-patients-with-painful-bone-metastases
#2
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: In patients who receive palliative radiation therapy (RT) for painful bone metastases, 40% experience a transient increase in pain known as a pain flare. Prophylactic dexamethasone has been shown to reduce pain flare incidence to 25%. We aimed to identify DNA biomarkers associated with pain flare and dexamethasone response. METHODS: Daily pain levels were recorded by 81 patients who received a single 8 Gy RT for painful bone metastases, of which 50 also received prophylactic dexamethasone...
September 20, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156910/genetic-biomarkers-associated-with-changes-in-quality-of-life-and-pain-following-palliative-radiotherapy-in-patients-with-bone-metastases
#3
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: Patients with bone metastases undergoing palliative radiation therapy (RT) may experience changes in both the functional and symptomatic aspects of quality of life (QOL). The European Organization of Cancer Research and Treatment (EORTC) QOL Questionnaire Core-15 Palliative (QLQ-C15-PAL) is a validated questionnaire employed to assess QOL specifically in palliative patients. Our study aimed to identify single-nucleotide variant (SNV) genetic biomarkers associated with changes in QOL and pain...
September 28, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156909/genetic-biomarkers-associated-with-response-to-palliative-radiotherapy-in-patients-with-painful-bone-metastases
#4
Anthony Furfari, Bo Angela Wan, Keyue Ding, Andrew Wong, Liting Zhu, Andrea Bezjak, Rebecca Wong, Carolyn F Wilson, Carlo DeAngelis, Azar Azad, Edward Chow, George S Charames
BACKGROUND: Palliative radiotherapy (RT) is effective in patients with painful bone metastases. Genetic factors may identify subgroup of patients who responded to RT. To identify DNA biomarkers associated with response to palliative RT. METHODS: Patients who received a single 8 Gy dose of RT for painful bone metastases were categorised into responders (n=36), non-responders (NR) (n=71). Saliva samples were sequenced to identify single-nucleotide variants (SNVs) in genes with known disease-causing variants from inflammation, radiation response, and DNA damage pathways...
October 10, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156903/gender-differences-in-pain-and-patient-reported-outcomes-a-secondary-analysis-of-the-ncic-ctg-sc-23-randomized-trial
#5
Selina Chow, Keyue Ding, Bo Angela Wan, Michael Brundage, Ralph M Meyer, Abdenour Nabid, Pierre Chabot, Genevievev Coulombe, Shahida Ahmed, Joda Kuk, A Rashid Dar, Aamer Mahmud, Alysa Fairchild, Carolyn F Wilson, Jackson S Y Wu, Kristopher Dennis, Carlo DeAngelis, Rebecca K S Wong, Liting Zhu, Edward Chow
BACKGROUND: Gender differences may contribute to variations in disease presentations and health outcomes. To explore the gender difference in pain and patient reported outcomes in cancer patients with bone metastases undergoing palliative radiotherapy on the National Cancer Institute of Canada (NCIC) SC.23 randomized trial. METHODS: Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life (QOL) bone metastases module (QLQ-BM22) and EORTC QOL Core-15-Palliative (QLQ-C15-PAL) before treatment and at days 10 and 42 after a single 8 Gy radiation treatment...
August 29, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156902/symptomatic-palliation-with-radiotherapy-in-extensive-heterotopic-ossifications
#6
Mary Jiayi Tao, Linda Probyn, Michael Poon, Hans Kreder, Bo Angela Wan, Patrick Diaz, Edward Chow
Heterotopic ossification (HTO) is the dystrophic formation of mature lamellar bone outside the confines of normal osseous tissues. It is frequently a complication which occurs following traumatic insult, both iatrogenic and non-iatrogenic, and neurological compromise. While mild degree of disease is often asymptomatic, significant pain and mobility limitations may result in reduced quality of life in advanced cases. Currently, the commonly accepted management for patients experiencing significant symptomatic HTOs is a combination therapy of surgical excision with prophylactic radiotherapy in the immediate perioperative period...
September 12, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156895/survival-analysis-of-malignant-epidural-spinal-cord-compression-after-palliative-radiotherapy-using-tokuhashi-scoring-system-and-the-impact-of-systemic-therapy
#7
Wing Ho Mui, Tai Chung Lam, Frank Chi Sing Wong, Wing King Sze
BACKGROUND: Previous studies have shown similar clinical outcomes of both single and multi-fraction (Fr) radiation therapy among malignant epidural spinal cord compression (MSCC) patients with poor prognosis; whereas, patients expected to have longer survival may require long-course radiotherapy to prevent local failure. However, such a poor prognosis risk group has not yet been clearly identified for use in daily clinical practice. We examined if the known predictive Tokuhashi scoring system could be adapted in MSCC patients treated with palliative radiation therapy...
August 29, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29149150/the-hopeless-case-palliative-cryoablation-and-cementoplasty-procedures-for-palliation-of-large-pelvic-bone-metastases
#8
Tyler M Coupal, Kevin Pennycooke, Paul I Mallinson, Hugue A Ouellette, Paul W Clarkson, Pippa Hawley, Peter L Munk
BACKGROUND: Metastases to the bone are common in cancer patients, and it has been estimated that up to 50% of patients with pelvic bone metastases will not achieve adequate pain control with medications alone. This has led to a paradigm shift over recent years towards the use and development of minimally invasive image-guided treatment options for palliation of bony metastases. Despite these developments, large metastatic lesions are still often considered to be "hopeless cases" that would garner little to no benefit from image-guided intervention...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29147454/late-onset-chemo-radiation-induced-tracheoesophageal-fistula-in-squamous-cell-cancer-of-the-lung
#9
Ashraf Abugroun, Fatima Ahmed, Namrata Singh, Mojtaba Nadiri
We report a 72-year-old male with past medical history of stage IV squamous lung cancer treated with radiation therapy and chemotherapy with gemcitabine/carboplatin. One year later, he presented with hemoptysis treated with another session of palliative radiotherapy. Two weeks later, patient developed aspiration pneumonia and further workup showed trachea-esophageal fistula documented by barium swallow. This case shows a rare complication of chemotherapy and radiation therapy on the setting of primary lung cancer...
October 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29143898/the-multidisciplinary-approach-to-localized-pancreatic-adenocarcinoma
#10
REVIEW
Hiral D Parekh, Jason Starr, Thomas J George
Pancreatic adenocarcinoma 2030 (PCa) is predicted to be the second leading cause of cancer death in USA by 2030. To date, attempts at early detection have been unsuccessful. Therapies for resectable PCa include surgery followed by adjuvant chemotherapy with or without radiotherapy. Unfortunately, most patients with PCa present with advanced disease and thus only 20% of patients are potentially resectable upon presentation. Improved surgical techniques along with adjuvant combination chemotherapy have improved outcomes for patients with resectable disease...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29142161/treatment-and-outcomes-of-carcinoma-of-the-external-and-middle-ear-the-validity-of-en-bloc-resection-for-advanced-tumor
#11
Takuma Matoba, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Eiji Tachibana, Takeshi Okada, Shingo Murakami, Yasuhisa Hasegawa
Carcinoma of the external and middle ear is a very rare disease. Despite the various treatment modalities available, its prognosis is still poor. We aimed to analyze the treatment modalities, outcomes, and validity of surgical approaches, especially in advanced tumors in the ear. Twenty-five patients with carcinoma of the external and middle ear were retrospectively analyzed. The modified Pittsburgh staging system was used for staging of the patients. Overall and disease-free survival was estimated using of Kaplan-Meier method...
November 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29141407/partial-solar-radiation-exclusion-with-color-shade-nets-reduce-the-degradation-of-organic-acids-and-flavonoids-of-grape-berry-vitis-vinifera-l
#12
Johan Martínez-Lüscher, Christopher Cody Lee Chen, Luca Brillante, Sahap Kaan Kurtural
The incidence of solar radiation on red-skinned grapes can promote the synthesis of flavonoid desirable for wine production, elevated temperature may impair their accumulation. We performed a shade cloth trial covering the fruit zone (from pepper-corn size to maturity) with four polyethylene 1-meter curtains with different optical properties (20% shading factor Pearl colored and 40% shading factor Aluminet, Blue and Black colored) and a Control with no cover. Cluster temperature was 3.7°C lower on the Southwest side in Black-40% clusters during the warmest part of the day compared to Control...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29131990/non-thermal-near-infrared-exposure-photobiomodulates-cellular-responses-to-ionizing-radiation-in-human-full-thickness-skin-models
#13
Anke König, Nadja Zöller, Stefan Kippenberger, August Bernd, Roland Kaufmann, Paul G Layer, Anja Heselich
Ionizing and near-infrared radiation are both part of the therapeutic spectrum in cancer treatment. During cancer therapy ionizing radiation is typically used for non-invasive reduction of malignant tissue, while near-infrared photobiomodulation is utilized in palliative medical approaches, e.g. for pain reduction or impairment of wound healing. Furthermore, near-infrared is part of the solar wavelength spectrum. A combined exposure of these two irradiation qualities - either intentionally during medical treatment or unintentionally due to solar exposure - is therefore presumable for cancer patients...
November 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29113454/modulators-of-redox-metabolism-in-head-and-neck-cancer
#14
Xiaofei Chen, Jade Mims, Xiumei Huang, Naveen Singh, Edward A Motea, Sarah M Planchon, Muhammad Beg, Allen W Tsang, Mercedes Porosnicu, Melissa L Kemp, David A Boothman, Cristina Furdui
SIGNIFICANCE: Head and Neck Squamous Cell Cancer (HNSCC) is a complex disease characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Antibodies against Epidermal Growth Factor Receptor (EGFR) are used in definitive or palliative treatment. Recent Advances. Emerging targeted therapies against other proteins of interest as well as programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) immunotherapies are being explored in clinical trials...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29113302/clinical-evaluation-of-palliative-chemoradiotherapy-for-metastatic-esophageal-cancer
#15
Hiroto Ueda, Masayuki Takeda, Shinya Ueda, Hisato Kawakami, Tatsuya Okuno, Naoki Takegawa, Hidetoshi Hayashi, Junji Tsurutani, Takao Tamura, Kazuki Ishikawa, Yasumasa Nishimura, Kazuhiko Nakagawa
Platinum-based chemotherapy is considered a standard treatment option for patients with metastatic esophageal carcinoma. However, the overall survival of patients receiving such treatment is <1 year. A common presenting symptom of esophageal cancer is dysphagia, which has a substantial impact on quality of life. We have now retrospectively evaluated the efficacy and safety of palliative chemoradiotherapy for patients with stage IV esophageal cancer, most of whom are unfit for curative chemoradiotherapy. Fifty consecutive patients diagnosed with stage IV esophageal cancer were treated with concurrent chemoradiotherapy at Kindai University Hospital between April 2008 and December 2014...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103357/noninvasive-liver-assessment-in-adult-patients-with-fontan-circulation-using-acoustic-radiation-force-impulse-elastography-and-hepatic-magnetic-resonance-imaging
#16
F Buendía-Fuentes, J L Melero-Ferrer, D Plaza-López, J Rueda-Soriano, A Osa-Saez, J Aguero, P Calvillo-Batllés, C Fonfria-Esparcia, A Ballesta-Cuñat, L Martí-Bonmatí, L Martínez-Dolz
BACKGROUND: Patients who have undergone the Fontan procedure are at risk of developing hepatic dysfunction. However, broad recommendations regarding liver monitoring are limited. The purpose of this study was to characterize the frequency of liver disease in adult Fontan patients using multimodality imaging (hepatic magnetic resonance imaging [MRI], acoustic radiation force impulse [ARFI] elastography, or hepatic ultrasound). METHODS: In a prospective cross-sectional analysis of adult patients palliated with a Fontan procedure, hepatic MRI, ARFI, and hepatic ultrasound were used to assess for liver disease...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29102263/gender-and-age-make-no-difference-in-the-re-irradiation-of-painful-bone-metastases-a-secondary-analysis-of-the-ncic-ctg-sc-20-randomized-trial
#17
Ronald Chow, Keyue Ding, Vithusha Ganesh, Ralph M Meyer, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid, Manouk van Acht, Rinus Wanders, Scott Babington, William F Demas, Carolyn F Wilson, Rebecca K S Wong, Michael Brundage, Liting Zhu, Edward Chow
BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation. MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions...
October 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29094103/multidisciplinary-gynecologic-oncology-clinic-in-botswana-a-model-for-multidisciplinary-oncology-care-in-low-and-middle-income-settings
#18
Surbhi Grover, Sebathu Philip Chiyapo, Priya Puri, Mohan Narasimhamurthy, Babe Eunice Gaolebale, Neo Tapela, Doreen Ramogola-Masire, Mukendi K A Kayembe, Thabo Moloi, Ponatshego Andrew Gaolebale
Purpose: Cervical cancer is a major cause of mortality in low- and middle-income countries (LMICs) and the most common cancer diagnosed in women in Botswana. Most women present with locally advanced disease, requiring chemotherapy and radiation. Care co-ordination requires input from a multidisciplinary team (MDT) to deliver appropriate, timely treatment. However, there are limited published examples of MDT implementation in LMICs. Methods: In May 2015, a weekly MDT clinic for gynecologic cancer care was initiated at Botswana's national referral facility...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29094085/awareness-and-perception-about-cancer-among-the-public-in-chennai-india
#19
Vidhubala Elangovan, Swaminathan Rajaraman, Barsha Basumalik, Dhivya Pandian
Purpose: Cancer-related stigma influences the way people perceive cancer, which renders cancer control-beginning with prevention and proceeding to palliation-a challenging task. This study aimed to assess the current levels of awareness and perceptions about cancer among people with various socioeconomic status and diverse backgrounds in the city of Chennai, India. Patients and Methods: The sample population (N = 2,981; 18 to 88 years of age) was stratified into four groups: patients (n = 510), caregivers (n = 494) consulting at the Cancer Institute (Women Indian Association), college students (n = 978), and general public (n = 999)...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29089533/proton-minibeam-radiation-therapy-spares-normal-rat-brain-long-term-clinical-radiological-and-histopathological-analysis
#20
Yolanda Prezado, Gregory Jouvion, David Hardy, Annalisa Patriarca, Catherine Nauraye, Judith Bergs, Wilfredo González, Consuelo Guardiola, Marjorie Juchaux, Dalila Labiod, Remi Dendale, Laurène Jourdain, Catherine Sebrie, Frederic Pouzoulet
Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue damage resulting from radiotherapy treatments. This strategy partners the inherent advantages of protons for radiotherapy with the gain in normal tissue preservation observed upon irradiation with narrow, spatially fractionated beams. In this study, whole brains (excluding the olfactory bulb) of Fischer 344 rats (n = 16) were irradiated at the Orsay Proton Therapy Center. Half of the animals received standard proton irradiation, while the other half were irradiated with pMBRT at the same average dose (25 Gy in one fraction)...
October 31, 2017: Scientific Reports
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