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https://www.readbyqxmd.com/read/29677569/validation-of-the-ajcc-8th-prognostic-system-for-breast-cancer-in-an-asian-healthcare-setting
#1
R X Wong, F Y Wong, John Lim, W X Lian, Y S Yap
AIMS: We aim to validate the AJCC 8th edition prognostic staging system for breast cancer in an Asian setting. METHODS: Clinico-pathologic information and cancer-specific survival (CSS) outcomes of 6287 stage I to III patients with invasive breast cancer who underwent upfront surgery at SingHealth institutions in Singapore from 2006 to 2014 were analyzed. Survival distributions for the different staging systems were estimated by the Kaplan-Meier method and compared using the log-rank tests...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29677568/validation-of-the-cps-eg-and-neo-bioscore-staging-systems-after-preoperative-systemic-therapy-for-breast-cancer-in-a-single-center-in-china
#2
Ling Xu, Xuening Duan, Bin Zhou, Yinhua Liu, Jingming Ye, Zhaorui Liu, Chao Ma, Hong Zhang, Shuang Zhang, Lanbo Zhang, Jianxin Zhao, Yuanjia Cheng
BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29677563/polysaccharide-of-hericium-erinaceus-attenuates-colitis-in-c57bl-6-mice-via-regulation-of-oxidative-stress-inflammation-related-signaling-pathways-and-modulating-the-composition-of-the-gut-microbiota
#3
Yilin Ren, Yan Geng, Yan Du, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong Xu
Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown etiology. Hericium erinaceus (H. erinaceus) is a Chinese medicinal fungus, with the effect of prevention and treatment of gastrointestinal disorders. In this study, we have tested the anti-inflammatory effect of polysaccharide of H. erinaceus (HECP, Mw: 86.67 kDa) in the model of dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. Our data indicated that HECP could improve clinical symptoms and down-regulate key markers of oxidative stresses, including nitric oxide (NO), malondialdehyde (MDA), total superoxide dismutase (T-SOD), and myeloperoxidase (MPO)...
March 16, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29677526/anti-inflammatory-effects-of-4-o-methyl-benzenesulfonyl-benzoxazolone-mbb-in-vivo-and-in-vitro-as-a-novel-nsaids-lead-compound
#4
Li Tang, Jie-Ran Luo, Dai-Tian Li, Rui Ge, Yun-Long Ma, Fei Xu, Tai-Gang Liang, Shu-Rong Ban, Qing-Shan Li
BACKGROUND: Great attention has been paid to the development of novel anti-inflammatory drugs to overcome the adverse reactions of traditional drugs. Recently, a new compound 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) we have prepared attracted our attention for its promising anti-inflammatory activity and low toxicity. The present study aimed to further investigate the anti-inflammatory effects of MBB both in vivo and in vitro in order to determine its potential as a novel NSAIDs lead compound...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#5
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677091/factors-associated-with-revision-surgery-after-internal-fixation-of-hip-fractures
#6
Sheila Sprague, Emil H Schemitsch, Marc Swiontkowski, Gregory J Della Rocca, Kyle J Jeray, Susan Liew, Gerard P Slobogean, Sofia Bzovsky, Diane Heels-Ansdell, Qi Zhou, Mohit Bhandari
BACKGROUND: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery...
May 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29677070/heavy-alcohol-use-among-deceased-donors-does-not-impact-recipient-outcomes-after-liver-transplantation
#7
Sumant S Arora, Khushdeep S Chahal, Page Axley, Devin E Eckhoff, Yong-Fang Kuo, Sanjaya K Satapathy, Russell Wiesner, Ashwani K Singal
BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks/day) are scanty. METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with not heavy drinking (ND) donors. RESULTS: Of 56 182 first LTs performed in the US for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676945/model-for-predicting-breast-cancer-risk-in-women-with-atypical-hyperplasia
#8
Amy C Degnim, Stacey J Winham, Ryan D Frank, V Shane Pankratz, William D Dupont, Robert A Vierkant, Marlene H Frost, Tanya L Hoskin, Celine M Vachon, Karthik Ghosh, Tina J Hieken, Jodi M Carter, Lori A Denison, Brendan Broderick, Lynn C Hartmann, Daniel W Visscher, Derek C Radisky
Purpose Women with atypical hyperplasia (AH) on breast biopsy have an aggregate increased risk of breast cancer (BC), but existing risk prediction models do not provide accurate individualized estimates of risk in this subset of high-risk women. Here, we used the Mayo benign breast disease cohort to develop and validate a model of BC risk prediction that is specifically for women with AH, which we have designated as AH-BC. Patients and Methods Retrospective cohorts of women age 18 to 85 years with pathologically confirmed benign AH from Rochester, MN, and Nashville, TN, were used for model development and external validation, respectively...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29676944/integration-of-clinical-variables-for-the-prediction-of-late-distant-recurrence-in-patients-with-estrogen-receptor-positive-breast-cancer-treated-with-5-years-of-endocrine-therapy-cts5
#9
Mitch Dowsett, Ivana Sestak, Meredith M Regan, Andrew Dodson, Giuseppe Viale, Beat Thürlimann, Marco Colleoni, Jack Cuzick
Purpose Estimating risk of late distant recurrence (DR) is an important goal for managing women with hormone receptor-positive breast cancer after 5 years of endocrine treatment without recurrence. We developed and validated a simple clinicopathologic tool (Clinical Treatment Score post-5 years [CTS5]) to estimate residual risk of DR after 5 years of endocrine treatment. Patients and Methods The ATAC (Arimidex, Tamoxifen, Alone or in Combination) data set (N = 4,735) was used to create a prognostic score for post-5-year risk of DR...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29676940/differential-compensation-of-two-cyclooxygenases-in-renal-homeostasis-is-independent-of-prostaglandin-synthetic-capacity-under-basal-conditions
#10
Xinzhi Li, Liudmila L Mazaleuskaya, Laurel L Ballantyne, Hu Meng, Garret A FitzGerald, Colin D Funk
The distinct functions of each cyclooxygenase (COX) isoform in renal homeostasis have been the subject of intense investigation for many years. We took the novel approach of using 3 characterized mouse lines, where the prostaglandin (PG)-endoperoxide synthase genes 1 and 2 ( Ptgs1 and Ptgs2) substitute for one another to delineate distinct roles and the potential for COX isoform substitution. Flipped Ptgs genes generate a reversed COX-expression pattern in the kidney, where the knockin COX-2 is highly expressed...
April 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29676701/single-center-long-term-results-of-pediatric-liver-transplantation
#11
Mohammad Hussein Al Sayyed, Alireza Shamsaeefar, Saman Nikeghbalian, Seyyed Mohsen Dehghani, Ali Bahador, Masood Dehghani, Razieh Rasekh, Siavash Gholami, Bahareh Khosravi, Seyyed Ali Malek Hosseini
OBJECTIVES: Liver replacement continues to be the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the rare donor organs, complex surgical demands, and the necessity to prevent long-term complications. Our objectives were to analyze 16 years of experience in the Shiraz University Organ Transplant Center. MATERIALS AND METHODS: We retrospectively analyzed the records of 752 patients (< 18 years old) who underwent orthotopic liver transplant at our center over a 16-year period...
April 20, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29676444/ethnic-disparity-in-primary-cutaneous-cd30-t-cell-lymphoproliferative-disorders-an-analysis-of-1496-cases-from-the-us-national-cancer-database
#12
Chang Su, Kevin A Nguyen, Harrison X Bai, Cheryl K Zogg, Ya Cao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang, Rong Xiao
Primary cutaneous CD30+ T cell lymphoproliferative disorders (PCLPD), the second most common type of primary cutaneous T cell lymphomas, accounts for approximately 25-30% of cutaneous T-cell lymphoma cases. However, only small retrospective studies have been reported. We aimed to identify prognostic factors and evaluate the overall survival (OS) of patients with PCLPD stratified by ethnicity. We identified 1496 patients diagnosed with PCLPD between 2004 and 2014 in the US National Cancer Database. Chi-square test and anova were used to evaluate differences in demographic and disease characteristics, socioeconomic factors and treatments received...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676390/receiving-hypertensive-donor-grafts-is-associated-with-inferior-prognosis-in-simultaneous-liver-kidney-transplantation-recipients
#13
Zebin Zhu, Shanzhou Huang, Qiang Zhao, Yunhua Tang, Zhiheng Zhang, Linhe Wang, Weiqiang Ju, Zhiyong Guo, Xiaoshun He
BACKGROUND The impact of hypertensive (HTN) donor grafts on the prognosis of simultaneous liver-kidney transplantation (SLKT) patient is not known, and an applicable risk scoring system for SLKT patient survival is lacking. This study aimed to evaluate the impact of donor HTN on patient survival of SLKT recipients and to identify independent risk factors. MATERIAL AND METHODS Data from 3844 adult SLKT recipients receiving deceased donor grafts from March 2002 to December 2014 in the Scientific Registry of Transplant Recipients (SRTR) database were retrospectively analyzed...
April 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29676191/treatment-according-to-guidelines-may-bridge-the-gender-gap-in-outcome-for-patients-with-stage-t1-urinary-bladder-cancer
#14
Carin Sjöström, Andreas Thorstenson, Viveka Ströck, Abolfazl Hosseini-Aliabad, Firas Aljabery, Fredrik Liedberg, Amir Sherif, Per-Uno Malmström, Johan Rosell, Truls Gårdmark, Staffan Jahnson
OBJECTIVE: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. MATERIALS AND METHODS: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan-Meier and log-rank tests and Cox proportional hazards analysis...
April 20, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29676134/-colorectal-cancer-preventive-effect-of-combined-administration-of-phenolic-acids-and-supercritical-extracts-from-angelica-sinensis
#15
Yu Peng, Bo-Chen Zhao, Qian Kang, Jia Liu, Cheng Chen, Bing-Shao Li, Yuan-Ping Xie, Qing Wu
This study aimed to investigate the colorectal cancer preventive effect of the combined administration of phenolic acids and supercritical extracts from Angelica sinensis. The AOM/DSS model in mice was adopted. Phenolic acids were administrated orally in the initial stage of the model at a dose of 1 g·kg⁻¹ BW, which was combined withtherectal administration with three doses of supercritical extracts (15, 30, 60 g·kg⁻¹ BW). PCNA, 8-oxoguaine, γ-H2AX, iNOS and COX-2 were tested by immunohistochemistry and Western blot assays...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675983/the-natural-history-of-asymptomatic-calyceal-stones
#16
Maitrey Padmasambhav Darrad, Sachin Yallappa, John Metcalfe, Kesavapillai Subramonian
OBJECTIVES: To evaluate the outcomes of patients with incidentally detected asymptomatic calyceal stones on active surveillance, and to identify risk factors for stone-related adverse events. SUBJECTS & METHODS: In this retrospective case series, we identified all renal units with non-contrast CT diagnosed asymptomatic calyceal stones in a single reference centre between August 2005 and August 2016. Primary endpoints were spontaneous stone passage and need for stone-related surgical intervention...
April 19, 2018: BJU International
https://www.readbyqxmd.com/read/29675892/dna-repair-protein-xpa-is-differentially-expressed-in-colorectal-cancer-and-predicts-better-prognosis
#17
Xue Feng, Jingwei Liu, Yuehua Gong, Kaihua Gou, Huaiwei Yang, Yuan Yuan, Chengzhong Xing
As an indispensable factor in DNA damage recognition step of nucleotide excision repair, XPA interacts with a series of proteins to initiate repair process. The expression characteristics of XPA in colorectal cancer (CRC) and its influence on CRC prognosis remain elusive. Tissue specimens of CRC and nontumor adjacent tissues from 283 patients were collected. XPA protein expressions were detected by immunohistochemistry staining. Nonparametric test was used to investigate the difference of XPA expression between CRC and nontumor adjacent tissues, as well as the correlation between XPA expression and clinicopathological parameters of CRC...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29675722/contrast-enhanced-or-noncontrast-ct-for-renal-colic-utilizing-urinalysis-and-patient-history-of-urolithiasis-to-decide
#18
Vishal Desai, Mougnyan Cox, Sandeep Deshmukh, Christopher G Roth
PURPOSE: In the emergency setting, flank pain commonly leads to a noncontrast CT despite a significant percentage of patients having alternative diagnoses, often difficult to characterize without contrast. We investigated the combined utility of urinalysis and history of urolithiasis in identifying patients who are unlikely to have urolithiasis and may benefit from a contrast-enhanced study. METHODS: Retrospective review of 350 patients from May 2013 to May 2016 was performed for patients in the emergency department with renal colic that underwent noncontrast CT and urinalysis testing...
April 20, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29675108/increased-aurka-gene-copy-number-correlates-with-poor-prognosis-and-predicts-the-efficacy-of-high-dose-interferon-therapy-in-acral-melanoma
#19
Junya Yan, Jiayi Yu, Xiaowen Wu, Tianxiao Xu, Huan Yu, Jie Dai, Meng Ma, Huan Tang, Longwen Xu, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Yan Kong, Jun Guo
Background: AURKA kinase is an essential serine/threonine kinase for mitosis and chromosome stability. The aberrant amplification and overexpression of AURKA are commonly observed in various types of cancer, including cutaneous melanoma. However, the status and the clinical significance of AURKA copy number (CN) in acral melanoma (AM) have not been fully elucidated. Methods: Four hundred and seventy-two AM samples were included in the study. AURKA CN was examined using the QuantiGenePlex DNA Assay. We analysed the relationship of AURKA CN to clinicopathological characteristics and survival of patients with AM...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29675105/association-of-wwox-rs9926344-polymorphism-with-poor-prognosis-of-hepatocellular-carcinoma
#20
Wanyong Chen, Chenhao Zhou, Wentao Zhang, Manar Atyah, Yirui Yin, Lei Guo, Weiguo Tang, Qiongzhu Dong, Qinghai Ye, Ning Ren
Introduction: The WW domain-containing oxidoreductase (WWOX), widely expressed in human tissues, is considered as a tumor suppressor gene and plays an important role in the incidence and progression of human cancer, HCC included. This study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the WWOX gene and the prognosis of hepatocellular carcinoma (HCC) patients. Materials and Methods: After a total of 152 HCC patients were recruited, 8 cases with tumor recurrence within 2-years after operation and 8 cases without recurrence were selected randomly for SNP genotyping and screening using Affymetrix Array 6...
2018: Journal of Cancer
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