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https://www.readbyqxmd.com/read/29236294/acute-myeloid-leukemia-and-myelodysplastic-syndrome-after-adjuvant-chemotherapy-a-population-based-study-among-older-breast-cancer-patients
#1
Aron S Rosenstock, Jiangong Niu, Sharon H Giordano, Hui Zhao, Antonio C Wolff, Mariana Chavez-MacGregor
BACKGROUND: Chemotherapy for early breast cancer is associated with a small risk of developing myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The aim of this study was to determine the risk of developing AML or MDS after modern adjuvant chemotherapy in older breast cancer patients and to further define the risk of individual chemotherapy regimens. METHODS: Patients diagnosed with stage I to III breast cancer from 2003 to 2009 were identified in the Surveillance, Epidemiology, and End Results-Medicare and Texas Cancer Registry-Medicare linked databases...
December 13, 2017: Cancer
https://www.readbyqxmd.com/read/29236213/structural-probing-screening-and-structure-based-drug-repositioning-insights-into-the-identification-of-potential-cox-2-inhibitors-from-selective-coxibs
#2
Uma Devi Bommu, Kranthi Kumar Konidala, Rishika Pamanji, Suneetha Yeguvapalli
The rate-limiting enzyme cyclooxygenase-2 (COX-2) is considered as an insightful prognostic target for non-small cell lung cancer (NSCLC) therapy. Now, administration and prolonged utilization of selective COX-2 inhibitors (COXIBs) towards moderating the NSCLC has been associated with different side effects. In the present study, we focused on the structure-based drug repositioning approaches for predicting therapeutic potential de novo candidates for human COX-2. Due to discrepancies in the eminence of x-ray diffraction structures, creates a big barrier in drug discovery approach...
December 13, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29236136/occupational-class-and-the-changing-patterns-of-hospitalization-for-affective-and-neurotic-disorders-a-nationwide-register-based-study-of-the-finnish-working-age-population-1976-2010
#3
Pekka Varje, Anne Kouvonen, Lauri Kokkinen, Aki Koskinen, Ari Väänänen
PURPOSE: This study aimed to examine the long-term changes and socioeconomic disparities in hospitalization for affective and neurotic disorders among the Finnish working-age population from 1976 to 2010. METHODS: Register-based study, consisting of a 5-year follow-up of 3,223,624 Finnish working-age (18-64-year old) individuals in seven consecutive cohorts. We calculated the hazard ratios of psychiatric hospitalization for different occupational classes using Cox regression models...
December 13, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29235988/optimal-transformations-leading-to-normal-distributions-of-positron-emission-tomography-standardized-uptake-values
#4
Matthew Scarpelli, Jens Eickhoff, Enrique Cuna, Scott Perlman, Robert Jeraj
The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in normal SUV distributions. This study sought to identify optimal transformations leading to normally distributed PET SUVs extracted from tumors and assess the effects of therapy on the optimal transformations...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29235887/novel-4-methylsulfonylphenyl-derivatives-as-nsaids-with-preferential-cox-2-inhibition
#5
Noha H Amin, Asmaa A Mohammed, Khaled Ra Abdellatif
AIM: There has been an enormous commercial development following the introduction of selective COX-2 inhibitors. Efforts are continuously done to discover efficient and safe COX-2 inhibitors. RESULTS: A series of 4-methylsulfonylphenyl derivatives was designed, synthesized and screened for preferential inhibition of COX-2 over COX-1 isoforms and in vivo anti-inflammatory activity using the rat paw edema method. The most active ones were investigated via ulcerogenic liability and molecular docking...
December 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29235661/association-of-higher-daptomycin-dose-%C3%A2-7-mg-kg-with-improved-survival-in-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#6
Tristan T Timbrook, Aisling R Caffrey, Megan K Luther, Vrishali Lopes, Kerry L LaPlante
STUDY OBJECTIVE: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and cases series studies. The objective of this study was to evaluate the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia. DESIGN: Retrospective national cohort study...
December 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29235601/ruthenium-ii-arene-nsaid-complexes-inhibition-of-cyclooxygenase-and-antiproliferative-activity-against-cancer-cell-lines
#7
Poulami Mandal, Bidyut Kumar Kundu, Komal Vyas, Vidya Sabu, A Helen, Sandeep Singh Dhankhar, C M Nagaraja, Debojit Bhattacherjee, Krishna Pada Bhabak, Suman Mukhopadhyay
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of molecules which have been found to be active against cancer cells with chemopreventive properties by targeting cyclooxygenase (COX-1 and COX-2) and lipoxygenase (LOX), commonly upregulated (particularly COX-2) in malignant tumors. Arene ruthenium(ii) complexes with a pseudo-octahedral coordination environment containing different ancillary ligands have shown remarkable activity against primary and metastatic tumors as reported earlier. This work describes the synthesis of four novel ruthenium(ii)-arene complexes viz...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29235571/the-hypoxia-marker-caix-is-prognostic-in-the-uk-phase-iii-vortex-biobank-cohort-an-important-resource-for-translational-research-in-soft-tissue-sarcoma
#8
Laura Forker, Piers Gaunt, Stefano Sioletic, Patrick Shenjere, Robert Potter, Darren Roberts, Joely Irlam, Helen Valentine, David Hughes, Ana Hughes, Lucinda Billingham, Rob Grimer, Beatrice Seddon, Ananya Choudhury, Martin Robinson, Catharine M L West
BACKGROUND: Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy to features of tumour biology, which need exploration in well-documented cohorts. Hypoxia has been linked to metastasis in STS and is targetable. This study evaluated hypoxia prognostic markers in the phase III adjuvant radiotherapy VorteX trial. METHODS: Formalin-fixed paraffin-embedded tumour biopsies, fresh tumour/normal tissue and blood were collected before radiotherapy...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235566/long-term-survival-outcomes-of-triple-receptor-negative-breast-cancer-survivors-who-are-disease-free-at-5-years-and-relationship-with-low-hormone-receptor-positivity
#9
S M Reddy, C H Barcenas, A K Sinha, L Hsu, S L Moulder, D Tripathy, G N Hortobagyi, V Valero
BACKGROUND: We counsel our triple-negative breast cancer (TNBC) patients that the risk of recurrence is highest in the first 5 years after diagnosis. However, there are limited data with extended follow-up on the frequency, characteristics, and predictors of late events. METHODS: We queried the MD Anderson Breast Cancer Management System database to identify patients with stage I-III TNBC who were disease free at 5 years from diagnosis. The Kaplan-Meier method was used to estimate yearly recurrence-free interval (RFI), recurrence-free survival (RFS), and distant relapse-free survival (DRFS), as defined by the STEEP criteria...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235565/anthropometric-measurements-and-survival-after-a-prostate-cancer-diagnosis
#10
Megan S Farris, Kerry S Courneya, Karen A Kopciuk, S Elizabeth McGregor, Christine M Friedenreich
BACKGROUND: Evidence regarding the role of anthropometrics in prostate cancer survival is inconsistent. We examined the associations between anthropometric measures and survival outcomes. METHODS: Men diagnosed with prostate cancer (n=987) were recruited into a population-based case-control study between 1997 and 2000 then a prospective cohort study between 2000 and 2002 where anthropometric measurements (weight, height, body mass index, waist circumference, waist-hip ratio) were taken and participants were followed up to 19 years for survival outcomes...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235463/exposure-to-magnetic-field-non-ionizing-radiation-and-the-risk-of-miscarriage-a-prospective-cohort-study
#11
De-Kun Li, Hong Chen, Jeannette R Ferber, Roxana Odouli, Charles Quesenberry
Magnetic field (MF) non-ionizing radiation is widespread and everyone is exposed to some degree. This prospective cohort study of 913 pregnant women examined the association between high MF exposure and miscarriage risk. Cox (proportional hazards) regression was used to examine the association. After controlling for multiple other factors, women who were exposed to higher MF levels had 2.72 times the risk of miscarriage (hazard ratio = 2.72, 95% CI: 1.42-5.19) than those with lower MF exposure. The increased risk of miscarriage associated with high MF was consistently observed regardless of the sources of high MF...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235044/worse-survival-after-breast-cancer-in-women-with-anorexia-nervosa
#12
Annet Bens, Fotios C Papadopoulos, Eero Pukkala, Anders Ekbom, Mika Gissler, Lene Mellemkjær
PURPOSE: A history of anorexia nervosa has been associated with a reduced risk of developing breast cancer. We investigated survival after breast cancer among women with a prior anorexia nervosa diagnosis compared with women in a population comparison group. METHODS: This register-based study included combined data from Sweden, Denmark and Finland. A total of 76 and 1462 breast cancer cases identified among 22,654 women with anorexia nervosa and 224,619 women in a population comparison group, respectively, were included in the study...
December 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29235000/is-neoadjuvant-therapy-sufficient-in-resected-pancreatic-cancer-patients-a-national-study
#13
Susanna W L de Geus, Gyulnara G Kasumova, Mariam F Eskander, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng
BACKGROUND: Despite the increasing use of neoadjuvant treatment, the question of whether preoperatively treated, successfully resected patients should receive additional postoperative adjuvant treatment remains unanswered. We evaluate the impact of adjuvant therapy following neoadjuvant treatment and pancreatectomy in pancreatic cancer patients in a large national study. METHODS: We used the National Cancer Data Base between 2006 and 2013 to identify resected, non-metastatic pancreatic adenocarcinoma patients who received neoadjuvant chemo(radio)therapy followed by pancreatectomy...
October 4, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29234949/curc-mpeg454-a-pegylated-curcumin-derivative-improves-anti-inflammatory-and-antioxidant-activities-a-comparative-study
#14
Fei Cheng, Yuhe Chen, Zhu Zhan, Yu Liu, Peng Hu, Hong Ren, Huadong Tang, Mingli Peng
We previously demonstrated that a PEGylated curcumin (Curc-mPEG454) significantly inhibited cyclooxygenase 2 (COX-2) expression and improved the progression of liver fibrosis. The current study systematically evaluates its anti-inflammatory and antioxidant activities in vitro in a comparative study with curcumin, aspirin, NS-398, and vitamin C. RAW264.7 murine macrophages were pretreated with Curc-mPEG454, curcumin, aspirin, NS-398, or vitamin C at the indicated concentration for 2 h; then, the cells were stimulated with 1 μg/mL lipopolysaccharide (LPS) for 24 h...
December 13, 2017: Inflammation
https://www.readbyqxmd.com/read/29234709/repeating-platinum-bevacizumab-in-recurrent-or-progressive-cervical-cancer-yields-marginal-survival-benefits
#15
Abigail S Zamorano, Leping Wan, Matthew A Powell, L Stewart Massad
Our objective was to assess overall survival of cervical cancer patients following prior platinum/bevacizumab chemotherapy, comparing retreatment with platinum/bevacizumab with alternative therapies. A retrospective analysis was performed of women who received platinum/bevacizumab (PB) chemotherapy for cervical cancer at Washington University between July 1, 2005 and December 31, 2015. Wilcoxon rank-sum exact test and Fisher's exact test were used to compare the treatment groups, and Kaplan Meier curves were generated...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29234633/clinical-factors-predicting-better-survival-outcome-for-pulmonary-metastasectomy-of-hepatocellular-carcinoma
#16
Tse-Ming Kuo, Kai-Ming Chang, Tsun-I Cheng, Kuo-Jang Kao
Background: In patients with lung metastasis of hepatocellular carcinoma (HCC), it remains uncertain how a better survival outcome can be predicted after metastasectomy. This study aims to identify clinical factors that may be used to guide patient selection for such a therapeutic modality. A total of 28 patients who received pulmonary metastasectomy for HCC between 1993 and 2012 were identified. All relevant clinical factors were extracted from medical records up to September 2015. Patients were classified into high- and low-risk groups according to survival outcome after metastasectomy...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234628/adoption-of-sorafenib-for-the-treatment-of-advanced-stage-hepatocellular-carcinoma-in-oncology-practices-in-the-united-states
#17
Helen M Parsons, Quyen Chu, Jordan J Karlitz, Jennifer L Stevens, Linda C Harlan
Background: The adoption of sorafenib into oncology practice as a first-line systemic treatment for advanced hepatocellular carcinoma (HCC) is not well understood. We examined sorafenib use since Food and Drug Administration (FDA) approval in 2007 and associated survival for individuals diagnosed with advanced HCC, conducting a population-based evaluation of treatment patterns and outcomes for this newly approved drug in the US over time. Methods: We identified individuals diagnosed with Barcelona Clinic Liver Cancer Stage C from the 2007 and 2012 National Cancer Institute Patterns of Care study...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234444/the-effects-of-thai-herbal-ha-rak-formula-on-cox-isoform-expression-in-human-umbilical-vein-endothelial-cells-induced-by-il-1%C3%AE
#18
Titchaporn Palo, Athiwat Thaworn, Phornnapa Charoenkij, Onusa Thamsermsang, Sirikul Chotewuttakorn, Pinpat Tripatara, Tawee Laohapand, Pravit Akarasereenont
Objective: To investigate the modulated effects of HRF on cyclooxygenase isoform expression and its activity, using the human umbilical vein endothelial cell (HUVEC) model induced by interleukin-1 beta (IL-1β). Methods: Cells were treated with indomethacin (positive control), HRF, and its components at various concentrations prior to treatment with IL-1β at 24 h. Cell viability was determined by MTT assay. Moreover, the anti-inflammatory effects of HRF and its components through mRNA and protein expression were established using real-time quantitative PCR and Western blot, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234401/trans-cinnamaldehyde-inhibits-microglial-activation-and-improves-neuronal-survival-against-neuroinflammation-in-bv2-microglial-cells-with-lipopolysaccharide-stimulation
#19
Yan Fu, Pin Yang, Yang Zhao, Liqing Zhang, Zhangang Zhang, Xianwen Dong, Zhongping Wu, Ying Xu, Yongjun Chen
Background: Microglial activation contributes to neuroinflammation and neuronal damage in neurodegenerative disorders including Alzheimer's and Parkinson's diseases. It has been suggested that neurodegenerative disorders may be improved if neuroinflammation can be controlled. trans-cinnamaldehyde (TCA) isolated from the stem bark of Cinnamomum cassia possesses potent anti-inflammatory capability; we thus tested whether TCA presents neuroprotective effects on improving neuronal survival by inhibiting neuroinflammatory responses in BV2 microglial cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234262/physical-activity-decreases-kidney-cancer-mortality
#20
Michael Liss, Loki Natarajan, Aws Hasan, Jonathan L Noguchi, Martha White, J Kellogg Parsons
Background: To investigate associations of kidney cancer mortality with modifiable risk factors of obesity, physical activity, and smoking. Methods: We evaluate baseline data from US National Health Information Survey from 1998 through 2004 linked to mortality data reporting deaths through 2006. The primary outcome variable was kidney cancer-specific mortality and primary exposure variables were self-reported physical activity and body mass index (BMI). We utilized multivariable adjusted Cox proportional hazards regression models, with delayed entry to account for age at survey interview...
November 2017: Current Urology
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