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High-density Lipoprotein Cholesterol

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https://www.readbyqxmd.com/read/29165714/blood-lipid-genetic-scores-the-hmgcr-gene-and-cancer-risk-a-mendelian-randomization-study
#1
Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Background: It is unclear whether there are causal associations between blood lipids, statin use and cancer risks. Under certain assumptions, Mendelian randomization analysis of a genetic marker for an exposure eliminates reverse causation and confounding. Methods: We applied Mendelian randomization analysis to genetic scores, comprising 26-41 single-nucleotide polymorphisms (SNPs), as instrumental variables (IVs) for triglycerides and low- and high-density lipoprotein cholesterol (LDLC, HDLC), using a prospective cohort of 26 904 individuals in which there were 6607 incident cancers...
November 20, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29165093/a-randomized-double-blind-placebo-controlled-crossover-study-to-assess-the-safety-and-beneficial-effects-of-cassia-tora-supplementation-in-healthy-adults
#2
Himavanth Reddy Kambalachenu, Thandlam Muneeswa Reddy, Sirpurkar Dattatreya Rao, Kambalachenu Dorababu, Kanala Kodanda Reddy, Kvs Sarma
OBJECTIVE: The current clinical trial was aimed at evaluating the safety and beneficial effect of Cassia tora (C.tora) supplementation in healthy adults. DESIGN: A randomized, double blind, placebo controlled study with a crossover design was done on 60 healthy normal weight adults (age range: 20-55 yrs). The study consisted of 2 treatment phases of 24 weeks each with a washout period of 4 weeks between the phases. 30 subjects randomly allocated to the 'Placebo first' group and 30 to 'C...
November 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29164829/prevalence-of-metabolic-syndrome-and-associations-with-lipid-profiles-in-iranian-men-a-population-based-screening-program
#3
Abolfazl Mohammadbeigi, Hamid Farahani, Esmail Moshiri, Mahbobeh Sajadi, Robabeh Ahmadli, Sima Afrashteh, Salman Khazaei, Hossein Ansari
PURPOSE: Metabolic syndrome (MS) is characterized by a collection of interdependent disorders, including abdominal obesity, dyslipidemia, hyperglycemia, hypertension, and diabetes. The current study aimed to estimate the prevalence of MS in Qom, Iran. MATERIALS AND METHODS: A population-based screening program was conducted in the city of Qom, in 845 urban adult men over 25 years old in 2014. Abdominal obesity, fasting blood glucose (FBG), blood pressure, and the serum lipid profile were measured in subjects after fasting for at least 8 hours...
November 16, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29164590/the-effect-of-abdominal-obesity-in-patients-with-polycystic-ovary-syndrome-on-metabolic-parameters
#4
G Franik, A Bizoń, S Włoch, D Pluta, Ł Blukacz, H Milnerowicz, P Madej
OBJECTIVE: Polycystic ovarian syndrome and obesity contribute to the metabolic complications for women of reproductive age. The aim of present study was to analyze the effect of abdominal obesity expressed using waist/hip ratio (WHR) in patients with polycystic ovary syndrome on metabolic parameters. PATIENTS AND METHODS: The study included 659 women with PCOS with WHR <0.8 and ≥0.8 aged between 17 and 44 years. Patients were tested for follicular stimulating hormone, luteinizing hormone, 17-beta-estradiol, dehydroepiandrosterone sulfate, androstenedione, sex hormone binding globulin, and total lipid profile during the follicular phase (within 3 and 5 days of their menstrual cycle)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164116/potential-of-metformin-to-improve-cardiac-risk-in-postpartum-women-with-gestational-diabetes
#5
Oscar A Viteri, Mary Alice Sallman, Pauline M Berens, Pamela D Berens, Farah H Amro, Maria S Hutchinson, Susan M Ramin, Sean C Blackwell, Jerrie S Refuerzo, Judith A Smith
Objective: Pregnancy is associated with an increase in total cholesterol, high density lipoproteins (HDL), and low-density lipoproteins (LDL). Postpartum, HDL and LDL decrease over the first 12 weeks postpartum. Oxidized LDL (ox-LDL) is a marker of oxidative stress-related inflammation, which is associated with obesity and also with development of cardiovascular disease. Cardiovascular protection and weight loss are benefits from metformin, especially in women with diabetes. The objective of this study was to compare changes in lipid profiles and biomarkers for obesity during the initial 6 weeks postpartum between women with gestational diabetes mellitus (GDM) treated with metformin versus placebo...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29164048/a-retrospective-mid-and-long-term-follow-up-study-on-the-changes-in-hematologic-parameters-in-the-highly-exposed-residents-of-the-hebei-spirit-oil-spill-in-taean-south-korea
#6
Young-Hyun Choi, Jee-Young Hong, Moo-Sik Lee
Objectives: This study aimed to analyze changes in hematologic parameters in the residents of the areas highly contaminated by the Hebei Spirit Oil Spill in 2007 and those who participated in the clean-up activities. Methods: According to demographic characteristics, health status and behavior, and level of exposure to oil, we compared the hematologic results in 2009 and 2012 among 701 residents. The hematologic parameters were composed of white blood cell (WBC) count, and levels of hemoglobin, hematocrit (Hct), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose, glycosylated hemoglobin (HbA1c), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (T-chol), high-density lipoprotein (HDL), and triglyceride (TG)...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29163550/evaluation-of-alpha-1-antitrypsin-levels-and-serpina1-gene-polymorphisms-in-sickle-cell-disease
#7
Magda Oliveira Seixas Carvalho, André Luís Carvalho Santos Souza, Mauricio Batista Carvalho, Ana Paula Almeida Souza Pacheco, Larissa Carneiro Rocha, Valma Maria Lopes do Nascimento, Camylla Vilas Boas Figueiredo, Caroline Conceição Guarda, Rayra Pereira Santiago, Adekunle Adekile, Marilda de Souza Goncalves
Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated with the disease. We have found high AAT levels in SCD patients compared to controls, while mutant genotypes of SERPINA1 gene had decreased AAT levels, in both groups. AAT showed negative correlation with red blood cells, hemoglobin (Hb), hematocrit, high-density lipoprotein cholesterol, urea, creatinine, and albumin and was positively correlated with mean corpuscular Hb concentration, white blood cells, neutrophils, Hb S, bilirubin, lactate dehydrogenase, ferritin, and C-reactive protein...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162870/hdl-particles-incorporate-into-lipid-bilayers-a-combined-afm-and-single-molecule-fluorescence-microscopy-study
#8
Birgit Plochberger, Clemens Röhrl, Johannes Preiner, Christian Rankl, Mario Brameshuber, Josef Madl, Robert Bittman, Robert Ros, Erdinc Sezgin, Christian Eggeling, Peter Hinterdorfer, Herbert Stangl, Gerhard J Schütz
The process, how lipids are removed from the circulation and transferred from high density lipoprotein (HDL) - a main carrier of cholesterol in the blood stream - to cells, is highly complex. HDL particles are captured from the blood stream by the scavenger receptor, class B, type I (SR-BI), the so-called HDL receptor. The details in subsequent lipid-transfer process, however, have not yet been completely understood. The transfer has been proposed to occur directly at the cell surface across an unstirred water layer, via a hydrophobic channel in the receptor, or after HDL endocytosis...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162611/hdl-subspecies-defined-by-presence-of-apolipoprotein-c-iii-and-incident-coronary-heart-disease-in-four-cohorts
#9
Majken K Jensen, Sarah A Aroner, Kenneth J Mukamal, Jeremy D Furtado, Wendy S Post, Michael Y Tsai, Anne Tjønneland, Joseph F Polak, Eric B Rimm, Kim Overvad, Robyn L McClelland, Frank M Sacks
Background -The causal role of high density lipoprotein (HDL) cholesterol in cardioprotection has been questioned by genetic and randomized studies. Novel measures that relate to HDL function may contribute new information to prediction of cardiovascular risk. Apolipoprotein C-III (apoC-III) is a key regulator of lipoprotein metabolism. We investigated whether subspecies of HDL defined by apoC-III are associated with coronary heart disease (CHD). Methods -We used immuno-affinity chromatography to measure the apoA-I concentrations of HDL that contains and lacks apoC-III in two prospective studies of adults free of CHD...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29162605/changes-in-high-density-lipoprotein-cholesterol-efflux-capacity-after-bariatric-surgery-are-procedure-dependent
#10
Sean P Heffron, BingXue Lin, Manish Parikh, Bianca Scolaro, Steven J Adelman, Heidi L Collins, Jeffrey S Berger, Edward A Fisher
OBJECTIVE: High-density lipoprotein cholesterol efflux capacity (CEC) is inversely associated with incident cardiovascular events, independent of high-density lipoprotein cholesterol. Obesity is often characterized by impaired high-density lipoprotein function. However, the effects of different bariatric surgical techniques on CEC have not been compared. This study sought to determine the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on CEC. APPROACH AND RESULTS: We prospectively studied severely obese, nondiabetic, premenopausal Hispanic women not using lipid medications undergoing RYGB (n=31) or SG (n=36)...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29162363/sex-differences-in-associations-between-blood-lipids-and-cerebral-small-vessel-disease
#11
Z-G Yin, Q-S Wang, K Yu, W-W Wang, H Lin, Z-H Yang
BACKGROUND AND AIMS: Dyslipidemia predicts higher risk of coronary events and stroke and might be associated with cerebral small vessel disease (SVD). Previous studies linking blood lipids and SVD have yielded inconsistent results, which may be attributable to sex differences in lipids metabolism. The aim of this study was to investigate the relationships between blood lipids and SVD in neurologically healthy men and women. METHODS AND RESULTS: Consecutive 817 people aged 50 years or more were enrolled and underwent magnetic resonance imaging scans to evaluate the periventricular white matter lesions (PVWMLs), deep white matter lesions (DWMLs) and silent brain infarction (SBI)...
October 10, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29161303/nonlinear-dynamics-of-early-atherosclerotic-plaque-formation-may-determine-the-efficacy-of-high-density-lipoproteins-hdl-in-plaque-regression
#12
Alexander D Chalmers, Christina A Bursill, Mary R Myerscough
We use a computational model to explore the effect of foam cell accumulation on plaque regression following an increase in high density lipoprotein (HDL) influx into the plaque. Atherosclerotic plaque formation is the outcome of cellular and cytokine responses to low density lipoproteins (LDL) that penetrate the artery wall following an injury to the endothelium and become modified. We modelled the cells and cytokines that are most important in plaque formation using partial differential equations. The model includes monocytes and macrophages, foam cells, macrophage chemoattractants, endothelium-stimulating cytokines, modified low density lipoproteins (mod LDL) and HDL...
2017: PloS One
https://www.readbyqxmd.com/read/29161233/swimming-but-not-vitamin-e-ameliorates-prothrombotic-state-and-hypofibrinolysis-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#13
Hussein F Sakr, Amr M Abbas, Mohamed A Haidara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with a systemic procoagulant hypofibrinolysis state that is considered as a risk factor for microangiopathy and peripheral vascular diseases. Swimming exercise ameliorates the metabolic dysfunction in type 2 diabetes. Vitamin E is a natural antioxidant that reduces the risk of endothelial dysfunction in metabolic syndrome. The aim of the present study is to investigate the effect of combined swimming exercise with vitamin E on coagulation as well as blood fibrinolysis markers in rats with NAFLD...
November 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29159965/improvement-in-lipids-after-switch-to-boosted-atazanavir-or-darunavir-in-children-adolescents-with-perinatally-acquired-hiv-on-older-protease-inhibitors-results-from-the-pediatric-hiv-aids-cohort-study
#14
J Jao, W Yu, K Patel, T L Miller, B Karalius, M E Geffner, L A DiMeglio, A Mirza, J S Chen, M Silio, E J McFarland, R B Van Dyke, D Jacobson
OBJECTIVES: Dyslipidaemia is common in perinatally HIV-infected (PHIV) youth receiving protease inhibitors (PIs). Few studies have evaluated longitudinal lipid changes in PHIV youth after switch to newer PIs. METHODS: We compared longitudinal changes in fasting lipids [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TC:HDL-C ratio] in PHIV youth enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) study who switched to atazanavir/ritonavir (ATV/r)- or darunavir/ritonavir (DRV/r)-based antiretroviral therapy (ART) from an older PI-based ART and those remaining on an older PI...
November 21, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29159568/a-cross-sectional-and-longitudinal-study-between-association-of-n-3-polyunsaturated-fatty-acids-derived-from-fish-consumption-and-high-density-lipoprotein-heterogeneity
#15
Shigemasa Tani, Rei Matsuo, Kenji Kawauchi, Tsukasa Yagi, Wataru Atsumi, Atsushi Hirayama
Decreased high-density lipoprotein (HDL) particle size, cholesterol poor, apolipoprotein A-I-rich HDL particles leading to smaller HDL particle size, may be associated with an anti-atherosclerotic effect. The data are sparse regarding the relationship between n-3 polyunsaturated fatty acids [n-3 PUFAs: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and HDL particle size. This study was designed as a hospital-based cross-sectional study to investigate the relationship between the serum levels of n-3 PUFAs and the HDL-cholesterol/apolipoprotein A-1 ratio, as estimated by the HDL particle size, in patients with the presence of one or more risk factors for atherosclerotic cardiovascular disease (ASCVD)...
November 20, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29159554/detailed-description-of-change-in-serum-cholesterol-profile-with-incremental-weight-loss-after-restrictive-bariatric-surgery
#16
Geraldine J Ooi, Arul Earnest, Lisa Doyle, Cheryl Laurie, John M Wentworth, Ken Sikaris, Carel W le Roux, Paul R Burton, Paul E O'Brien, Wendy A Brown
INTRODUCTION: Dyslipidemia affects up to 75% of morbidly obese individuals and is a key driver of cardiovascular disease. Weight loss is an established strategy to improve metabolic risk, including dyslipidemia. We aimed to determine weight loss goals for resolution of serum lipid abnormalities, by measuring improvements during progressive weight loss in obese individuals. METHODS: We performed a prospective cohort study of obese individuals with the metabolic syndrome undergoing adjustable gastric banding...
November 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29159396/association-of-nonalcoholic-fatty-liver-disease-with-lower-brain-volume-in-healthy-middle-aged-adults-in-the-framingham-study
#17
Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29157582/serum-lipid-profile-sleep-disordered-breathing-and-blood-pressure-in-the-elderly-a-10-year-follow-up-of-the-proof-synapse-cohort
#18
Denis Monneret, Jean-Claude Barthélémy, David Hupin, Delphine Maudoux, Sébastien Celle, Emilia Sforza, Frédéric Roche
OBJECTIVES: Dyslipidemia, sleep-disordered breathing (SDB) and hypertension are comorbid factors evidenced in adults, but poorly studied in old people. This study aimed to examine the long-term evolution of the serum lipid profile, and its relationships with SDB and blood pressure (BP) in the elderly. METHODS: A ten-year follow-up of the prospective Prognostic Indicator of Cardiovascular and Cerebrovascular Events (PROOF) and the Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea (SYNAPSE) cohort, which initially included 1011 elderly subjects from the general population, and who were untreated by continuous positive airway pressure (CPAP)...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29157534/moderate-to-high-levels-of-cardiorespiratory-fitness-attenuate-the-effects-of-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-on-coronary-heart-disease-mortality-in-men
#19
Stephen W Farrell, Carrie E Finley, Carolyn E Barlow, Benjamin L Willis, Laura F DeFina, William L Haskell, Gloria L Vega
OBJECTIVE: To examine the prospective relationships among cardiorespiratory fitness (CRF), fasting blood triglyceride to high density lipoprotein cholesterol ratio (TG:HDL-C), and coronary heart disease (CHD) mortality in men. METHODS: A total of 40,269 men received a comprehensive baseline clinical examination between January 1, 1978, and December 31, 2010. Their CRF was determined from a maximal treadmill exercise test. Participants were divided into CRF categories of low, moderate, and high fit by age group and by TG:HDL-C quartiles...
November 14, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29157533/cardiorespiratory-fitness-cutoff-points-for-early-detection-of-present-and-future-cardiovascular-risk-in-children-a-2-year-follow-up-study
#20
José Castro-Piñero, Alejandro Perez-Bey, Víctor Segura-Jiménez, Virginia A Aparicio, Sonia Gómez-Martínez, Rocio Izquierdo-Gomez, Ascensión Marcos, Jonatan R Ruiz
OBJECTIVE: To examine the association between cardiorespiratory fitness (CRF) at baseline and cardiovascular disease (CVD) risk in 6- to 10-year-olds (cross-sectional) and 2 years later (8- to 12-year-olds [longitudinal]) and whether changes with age in CRF are associated with CVD risk in children aged 8 to 12 years. PATIENTS AND METHODS: Spanish primary schoolchildren (n=236) aged 6 to 10 years participated at baseline. Of the 23 participating primary schools, 22% (n=5) were private schools and 78% (n=18) were public schools...
November 10, 2017: Mayo Clinic Proceedings
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