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High-density Lipoprotein Cholesterol&cancer

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https://www.readbyqxmd.com/read/28106545/the-alterations-of-serum-fgf-21-levels-metabolic-and-body-composition-in-early-breast-cancer-patients-receiving-adjuvant-endocrine-therapy
#1
Murat Akyol, Ahmet Alacacioglu, Leyla Demir, Yuksel Kucukzeybek, Yasar Yildiz, Zehra Gumus, Mete Kara, Tarik Salman, Umut Varol, Halil Taskaynatan, Utku Oflazoglu, Vedat Bayoglu, Mustafa Oktay Tarhan
BACKGROUND: In early breast cancer patients, the effects of hormonal therapy (tamoxifen and aromatase inhibitors) on plasma fibroblast growth factor 21 (FGF-21), lipid levels and body composition have not yet been investigated. Therefore, we aimed to analyze the relationship between FGF-21 and body composition as well as the effects of tamoxifen and aromatase inhibitors on plasma lipid levels, FGF-21, and body composition. METHODS: A total of 72 patients were treated with either tamoxifen or aromatase inhibitors due to their menopausal status after adjuvant radiotherapy...
January 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28089627/the-relationship-between-tamoxifen-associated-nonalcoholic-fatty-liver-disease-and-the-prognosis-of-patients-with-early-stage-breast-cancer
#2
Meiying Yan, Jingxuan Wang, Qijia Xuan, Tieying Dong, Juan He, Qingyuan Zhang
PURPOSE: To investigate the relationship between tamoxifen-associated nonalcoholic fatty liver disease (NAFLD) and survival outcomes in patients with breast cancer. METHODS: Patients with early-stage invasive breast cancer after curative resection from January 2009 to June 2011 were selected. A total of 646 patients who were treated with tamoxifen were included. Patients diagnosed with NAFLD on ultrasonography were classified into the NAFLD and non-NAFLD groups...
December 24, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28057114/-a-case-control-study-on-the-association-between-serum-lipid-level-and-the-risk-of-breast-cancer
#3
L J Wei, C Zhang, H Zhang, X Wei, S X Li, J T Liu, X B Ren
Objective: To examine the association between serum lipids, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and the risk and progression of breast cancer in postmenopausal and premenopausal women. Methods: A review analysis of female patients who underwent breast cancer surgery and blood lipid metabolism testing in Tianjin One Hospital, from January 2013 to October 2013, was performed. A total of 1 081 patients were included in the final analysis...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28045962/association-of-tsh-elevation-with-all-cause-mortality-in-elderly-patients-with-chronic-kidney-disease
#4
Mei-Hsing Chuang, Kuo-Meng Liao, Yao-Min Hung, Yi-Chang Chou, Pesus Chou
Chronic kidney disease (CKD) is a widespread condition in the global population and is more common in the elderly. Thyroid-stimulating hormone (TSH) level increases with aging, and hypothyroidism is highly prevalent in CKD patients. However, the relationship between low thyroid function and mortality in CKD patients is unclear. Therefore, we conducted a retrospective cohort study to examine the relationship between TSH elevation and all-cause mortality in elderly patients with CKD. This retrospective cohort study included individuals ≥65 years old with CKD (n = 23,786) in Taipei City...
2017: PloS One
https://www.readbyqxmd.com/read/28028525/is-there-any-relationship-between-different-phenotypes-of-metabolic-syndrome-and-cardiovascular-mortality-rate
#5
Alireza Khosravi, Sareh Ahmadzadeh, Mojgan Gharipour, Jafar Golshahi, Masoumeh Sadeghi, Mahnaz Jozan, Nizal Sarrafzadegan
BACKGROUND: This study aimed to focus on different phenotypes of metabolic syndrome (MetS) and their impact on the cardiovascular disease (CVD) events among a sample of the Iranian population. MATERIALS AND METHODS: The Isfahan cohort study is a population-based, on-going longitudinal study of adults aged 35 years old or more, living in urban and rural areas of three counties in central Iran namely Isfahan, Najafabad and Arak. Participants were selected by multistage random sampling and were recruited to reflect the age, sex and urban/rural distribution of the community...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28018216/targeting-the-sr-b1-receptor-as-a-gateway-for-cancer-therapy-and-imaging
#6
REVIEW
Linda K Mooberry, Nirupama A Sabnis, Marlyn Panchoo, Bhavani Nagarajan, Andras G Lacko
Malignant tumors display remarkable heterogeneity to the extent that even at the same tissue site different types of cells with varying genetic background may be found. In contrast, a relatively consistent marker the scavenger receptor type B1 (SR-B1) has been found to be consistently overexpressed by most tumor cells. Scavenger Receptor Class B Type I (SR-BI) is a high density lipoprotein (HDL) receptor that facilitates the uptake of cholesterol esters from circulating lipoproteins. Additional findings suggest a critical role for SR-BI in cholesterol metabolism, signaling, motility, and proliferation of cancer cells and thus a potential major impact in carcinogenesis and metastasis...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28012211/derivation-and-validation-of-a-risk-scoring-model-to-predict-advanced-colorectal-neoplasm-in-adults-of-all-ages
#7
Hyo-Joon Yang, Sungkyoung Choi, Soo-Kyung Park, Yoon Suk Jung, Kyu Yong Choi, Taesung Park, Ji Yeon Kim, Dong Il Park
BACKGROUND AND AIMS: Little is known about how to include adults < 50 years in colonoscopy screening. This study aimed to derive a risk-scoring model incorporating laboratory indicators for metabolic risks to predict advanced colorectal neoplasia (ACN) in an asymptomatic Korean adults both younger and older than 50 years. METHODS: In this cross-sectional study, 70,812 consecutive adult recipients of a screening colonoscopy in a single health check-up center in Korea between 2003 and 2012 were enrolled...
December 24, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28006834/pretreatment-direct-bilirubin-and-total-cholesterol-are-significant-predictors-of-overall-survival-in-advanced-non-small-cell-lung-cancer-patients-with-egfr-mutations
#8
Yanwei Zhang, Jianlin Xu, Yuqing Lou, Song Hu, Keke Yu, Rong Li, Xueyan Zhang, Bo Jin, Baohui Han
This study was designed to examine the prediction of pretreatment circulating bilirubin and cholesterol for overall survival in 459 advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. Circulating total bilirubin, direct bilirubin (DB), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were measured at baseline. The mean age (standard deviation) of all study patients was 58.7 (10...
December 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28004415/serum-cholesterol-and-risk-of-lower-urinary-tract-symptoms-progression-results-from-the-reduction-by-dutasteride-of-prostate-cancer-events-study
#9
Tom Feng, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
OBJECTIVE: To determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men. METHODS: A post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried out in 2323 men with baseline International Prostate Symptom Score <8 and not taking benign prostatic hyperplasia or cholesterol medications. Cox proportion models were used to test the association between cholesterol, high-density lipoprotein, low-density lipoprotein and the cholesterol : high-density lipoprotein ratio with incident lower urinary tract symptoms, defined as first report of medical treatment, surgery or two reports of an International Prostate Symptom Score >14...
December 22, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27986818/mrna-levels-of-low-density-lipoprotein-receptors-are-overexpressed-in-the-foci-of-deep-bowel-endometriosis
#10
Luciano Gibran, Raul C Maranhão, Elaine R Tavares, Priscila O Carvalho, Maurício S Abrão, Sergio Podgaec
STUDY QUESTION: Is mRNA expression of LDL receptors altered in deep bowel endometriotic foci? SUMMARY ANSWER: mRNA expression of LDL receptors is up-regulated in deep bowel endometriotic foci of patients with endometriosis. WHAT IS KNOWN ALREADY: Several studies have demonstrated the overexpression of low-density lipoprotein receptors in various tumour cell lines and endometriosis has similar aspects to cancer, mainly concerning the pathogenesis of both diseases...
December 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27943172/defining-the-place-of-ezetimibe-atorvastatin-in-the-management-of-hyperlipidemia
#11
REVIEW
António Miguel Ferreira, Pedro Marques da Silva
Statin-ezetimibe combinations are a potentially advantageous therapeutic option for high-risk patients who need additional lowering of low-density lipoprotein cholesterol (LDL-C). These combinations may overcome some of the limitations of statin monotherapy by blocking both sources of cholesterol. Recently, a fixed-dose combination with atorvastatin, one of the most extensively studied statins, was approved and launched in several countries, including the USA. Depending on atorvastatin dose, this combination provides LDL-C reductions of 50-60%, triglyceride reductions of 30-40%, and high-density lipoprotein cholesterol (HDL-C) increases of 5-9%...
December 10, 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27939967/the-effect-of-preoperative-serum-triglycerides-and-high-density-lipoprotein-cholesterol-levels-on-the-prognosis-of-breast-cancer
#12
Xing Li, Hailin Tang, Jin Wang, Xinhua Xie, Peng Liu, Yanan Kong, Feng Ye, Zeyu Shuang, Zeming Xie, Xiaoming Xie
OBJECTIVES: Although dyslipidemia has been documented to be associated with several types of cancer including breast cancer, it remains uncertainty the prognostic value of serum lipid in breast cancer. The purpose of this study is to evaluate the association between the preoperative plasma lipid profile and the prognostic of breast cancer patients. METHODS: The levels of preoperative serum lipid profile (including cholesterol [CHO], Triglycerides [TG], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoAI], and apolipoprotein B [ApoB]) and the clinical data were retrospectively collected and reviewed in 1044 breast cancer patients undergoing operation...
December 8, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27930524/dietary-protein-and-fat-intake-in-relation-to-risk-of-colorectal-adenoma-in-korean
#13
Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
Consumption of red meat and alcohol are known risk factors for colorectal cancer, but associations for dietary fat remain unclear. We investigated the associations of dietary fat, protein, and energy intake with prevalence of colorectal adenoma.We performed a prospective cross-sectional study on asymptomatic persons who underwent a screening colonoscopy at a single center during a routine health check-up from May to December 2011. Dietary data were obtained via a validated Food Frequency Questionnaire (FFQ), assisted by a registered dietician...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27922919/association-between-sarcopenia-and-metabolic-syndrome-in-cancer-survivors
#14
Su Jung Lee, Nam Cho Kim
BACKGROUND: Advanced cancer treatments have improved survival from cancer, but the incidence of cardiovascular disease in survivors has recently increased. Sarcopenia and metabolic syndrome (MetS) are related to cancer survival, and sarcopenia is an emerging risk factor for cardiovascular disease. However, evidence of a relationship between sarcopenia and MetS in cancer survivors is lacking. OBJECTIVES: The aims of this study were to determine the prevalence of sarcopenia and MetS in cancer survivors and to investigate independent predictors of MetS in cancer survivors...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27900797/evidence-for-feedback-regulation-following-cholesterol-lowering-therapy-in-a-prostate-cancer-xenograft-model
#15
Elizabeth M Masko, Mahmoud A Alfaqih, Keith R Solomon, William T Barry, Christopher B Newgard, Michael J Muehlbauer, Nikolaos A Valilis, Tameika E Phillips, Susan H Poulton, Alexis R Freedland, Stephanie Sun, Shweta K Dambal, Sergio E Sanders, Everardo Macias, Michael R Freeman, Mark W Dewhirst, Salvatore V Pizzo, Stephen J Freedland
BACKGROUND: Epidemiologic data suggest cholesterol-lowering drugs may prevent the progression of prostate cancer, but not the incidence of the disease. However, the association of combination therapy in cholesterol reduction on prostate or any cancer is unclear. In this study, we compared the effects of the cholesterol lowering drugs simvastatin and ezetimibe alone or in combination on the growth of LAPC-4 prostate cancer in vivo xenografts. METHODS: Proliferation assays were conducted by MTS solution and assessed by Student's t-test...
November 30, 2016: Prostate
https://www.readbyqxmd.com/read/27895819/nutrition-insulin-resistance-and-dysfunctional-adipose-tissue-determine-the-different-components-of-metabolic-syndrome
#16
REVIEW
Juan Antonio Paniagua
Obesity is an excessive accumulation of body fat that may be harmful to health. Today, obesity is a major public health problem, affecting in greater or lesser proportion all demographic groups. Obesity is estimated by body mass index (BMI) in a clinical setting, but BMI reports neither body composition nor the location of excess body fat. Deaths from cardiovascular diseases, cancer and diabetes accounted for approximately 65% of all deaths, and adiposity and mainly abdominal adiposity are associated with all these disorders...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27893427/cholesterol-import-and-steroidogenesis-are-biosignatures-for-gastric-cancer-patient-survival
#17
Wei-Chun Chang, Shang-Fen Huang, Yang-Ming Lee, Hsueh-Chou Lai, Bi-Hua Cheng, Wei-Chung Cheng, Jason Yen-Ping Ho, Long-Bin Jeng, Wen-Lung Ma
Androgens, estrogens, progesterone and related signals are reported to be involved in the pathology of gastric cancer. However, varied conclusions exist based on serum hormone levels, receptor expressions, and in vitro or in vivo studies. This report used a web-based gene survival analyzer to evaluate biochemical processes, including cholesterol importing via lipoprotein/receptors (L/R route), steroidogenic enzymes, and steroid receptors, in gastric cancer patients prognosis. The sex hormone receptors (androgen receptor, progesterone receptor, and estrogen receptor ESR1 or ESR2), L/R route (low/high-density lipoprotein receptors, LDLR/LRP6/SR-B1 and lipoprotein lipase, LPL) and steroidogenic enzymes (CYP11A1, HSD3B1, CYP17, HSD17B1, HSD3B1, CYP19A1 and SRD5A1) were associated with 5-year survival of gastric cancer patients...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27886704/position-of-the-academy-of-nutrition-and-dietetics-vegetarian-diets
#18
Vesanto Melina, Winston Craig, Susan Levin
It is the position of the Academy of Nutrition and Dietetics that appropriately planned vegetarian, including vegan, diets are healthful, nutritionally adequate, and may provide health benefits for the prevention and treatment of certain diseases. These diets are appropriate for all stages of the life cycle, including pregnancy, lactation, infancy, childhood, adolescence, older adulthood, and for athletes. Plant-based diets are more environmentally sustainable than diets rich in animal products because they use fewer natural resources and are associated with much less environmental damage...
December 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27882089/gender-impact-on-the-correlation-between-thyroid-function-and-serum-lipids-in-patients-with-differentiated-thyroid-cancer
#19
Xue Li, Zhaowei Meng, Jian Tan, Ming Liu, Qiang Jia, Guizhi Zhang, Yajing He, Qing Zhang, Li Liu, Kun Song, Qing He, Mei Zhu, Shen Wang, Jianping Zhang, Wei Zheng, Renfei Wang, Tianpeng Hu, Na Liu, Arun Upadhyaya
The present study aimed to explore the association between thyroid stimulating hormone (TSH) and serum lipids in patients with differentiated thyroid cancer (DTC), with a focus on the risk of hyperlipidemia between different genders. The study included 352 DTC patients who were ready to receive I-131 therapy as well as 352 matched normal controls. In the DTC group, 157 patients were monitored for TSH and lipid parameters prior to and after 1 month of thyroxine therapy. Results were analyzed using t-tests, Pearson bivariate correlation and binary logistic regression analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27864712/associations-between-serum-lipids-and-breast-cancer-incidence-and-survival-in-the-e3n-prospective-cohort-study
#20
Mathilde His, Laureen Dartois, Guy Fagherazzi, Anne Boutten, Thierry Dupré, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus
PURPOSE: Several mechanistic studies support a role of cholesterol or its metabolites in breast cancer etiology, but associations have been inconsistent in epidemiological studies. In observational studies, possible reverse causation must be accounted for using a prospective design. We investigated prospective associations between pre-diagnostic serum lipid concentrations [total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides], and both breast cancer risk and survival in the E3N cohort study...
January 2017: Cancer Causes & Control: CCC
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