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High-density Lipoprotein Cholesterol&cancer

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https://www.readbyqxmd.com/read/27922919/association-between-sarcopenia-and-metabolic-syndrome-in-cancer-survivors
#1
Su Jung Lee, Nam Cho Kim
BACKGROUND: Advanced cancer treatments have improved survival from cancer, but the incidence of cardiovascular disease in survivors has recently increased. Sarcopenia and metabolic syndrome (MetS) are related to cancer survival, and sarcopenia is an emerging risk factor for cardiovascular disease. However, evidence of a relationship between sarcopenia and MetS in cancer survivors is lacking. OBJECTIVES: The aims of this study were to determine the prevalence of sarcopenia and MetS in cancer survivors and to investigate independent predictors of MetS in cancer survivors...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27900797/evidence-for-feedback-regulation-following-cholesterol-lowering-therapy-in-a-prostate-cancer-xenograft-model
#2
Elizabeth M Masko, Mahmoud A Alfaqih, Keith R Solomon, William T Barry, Christopher B Newgard, Michael J Muehlbauer, Nikolaos A Valilis, Tameika E Phillips, Susan H Poulton, Alexis R Freedland, Stephanie Sun, Shweta K Dambal, Sergio E Sanders, Everardo Macias, Michael R Freeman, Mark W Dewhirst, Salvatore V Pizzo, Stephen J Freedland
BACKGROUND: Epidemiologic data suggest cholesterol-lowering drugs may prevent the progression of prostate cancer, but not the incidence of the disease. However, the association of combination therapy in cholesterol reduction on prostate or any cancer is unclear. In this study, we compared the effects of the cholesterol lowering drugs simvastatin and ezetimibe alone or in combination on the growth of LAPC-4 prostate cancer in vivo xenografts. METHODS: Proliferation assays were conducted by MTS solution and assessed by Student's t-test...
November 30, 2016: Prostate
https://www.readbyqxmd.com/read/27895819/nutrition-insulin-resistance-and-dysfunctional-adipose-tissue-determine-the-different-components-of-metabolic-syndrome
#3
REVIEW
Juan Antonio Paniagua
Obesity is an excessive accumulation of body fat that may be harmful to health. Today, obesity is a major public health problem, affecting in greater or lesser proportion all demographic groups. Obesity is estimated by body mass index (BMI) in a clinical setting, but BMI reports neither body composition nor the location of excess body fat. Deaths from cardiovascular diseases, cancer and diabetes accounted for approximately 65% of all deaths, and adiposity and mainly abdominal adiposity are associated with all these disorders...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27893427/cholesterol-import-and-steroidogenesis-are-biosignatures-for-gastric-cancer-patient-survival
#4
Wei-Chun Chang, Shang-Fen Huang, Yang-Ming Lee, Hsueh-Chou Lai, Bi-Hua Cheng, Wei-Chung Cheng, Jason Yen-Ping Ho, Long-Bin Jeng, Wen-Lung Ma
Androgens, estrogens, progesterone and related signals are reported to be involved in the pathology of gastric cancer. However, varied conclusions exist based on serum hormone levels, receptor expressions, and in vitro or in vivo studies. This report used a web-based gene survival analyzer to evaluate biochemical processes, including cholesterol importing via lipoprotein/receptors (L/R route), steroidogenic enzymes, and steroid receptors, in gastric cancer patients prognosis. The sex hormone receptors (androgen receptor, progesterone receptor, and estrogen receptor ESR1 or ESR2), L/R route (low/high-density lipoprotein receptors, LDLR/LRP6/SR-B1 and lipoprotein lipase, LPL) and steroidogenic enzymes (CYP11A1, HSD3B1, CYP17, HSD17B1, HSD3B1, CYP19A1 and SRD5A1) were associated with 5-year survival of gastric cancer patients...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27886704/position-of-the-academy-of-nutrition-and-dietetics-vegetarian-diets
#5
Vesanto Melina, Winston Craig, Susan Levin
It is the position of the Academy of Nutrition and Dietetics that appropriately planned vegetarian, including vegan, diets are healthful, nutritionally adequate, and may provide health benefits for the prevention and treatment of certain diseases. These diets are appropriate for all stages of the life cycle, including pregnancy, lactation, infancy, childhood, adolescence, older adulthood, and for athletes. Plant-based diets are more environmentally sustainable than diets rich in animal products because they use fewer natural resources and are associated with much less environmental damage...
December 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27882089/gender-impact-on-the-correlation-between-thyroid-function-and-serum-lipids-in-patients-with-differentiated-thyroid-cancer
#6
Xue Li, Zhaowei Meng, Jian Tan, Ming Liu, Qiang Jia, Guizhi Zhang, Yajing He, Qing Zhang, Li Liu, Kun Song, Qing He, Mei Zhu, Shen Wang, Jianping Zhang, Wei Zheng, Renfei Wang, Tianpeng Hu, Na Liu, Arun Upadhyaya
The present study aimed to explore the association between thyroid stimulating hormone (TSH) and serum lipids in patients with differentiated thyroid cancer (DTC), with a focus on the risk of hyperlipidemia between different genders. The study included 352 DTC patients who were ready to receive I-131 therapy as well as 352 matched normal controls. In the DTC group, 157 patients were monitored for TSH and lipid parameters prior to and after 1 month of thyroxine therapy. Results were analyzed using t-tests, Pearson bivariate correlation and binary logistic regression analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27864712/associations-between-serum-lipids-and-breast-cancer-incidence-and-survival-in-the-e3n-prospective-cohort-study
#7
Mathilde His, Laureen Dartois, Guy Fagherazzi, Anne Boutten, Thierry Dupré, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus
PURPOSE: Several mechanistic studies support a role of cholesterol or its metabolites in breast cancer etiology, but associations have been inconsistent in epidemiological studies. In observational studies, possible reverse causation must be accounted for using a prospective design. We investigated prospective associations between pre-diagnostic serum lipid concentrations [total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides], and both breast cancer risk and survival in the E3N cohort study...
November 18, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27856457/carriers-of-the-pcsk9-proprotein-convertase-subtilisin-kexin-9-r46l-variant-are-characterized-by-an-antiatherogenic-lipoprotein-profile-assessed-by-nuclear-magnetic-resonance-spectroscopy
#8
Rutger Verbeek, Marjorie Boyer, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Nicholas Wareham, Kay-Tee Khaw, Benoit J Arsenault
OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance spectroscopy in 2373 participants of the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27812119/daesiho-tang-is-an-effective-herbal-formulation-in-attenuation-of-obesity-in-mice-through-alteration-of-gene-expression-and-modulation-of-intestinal-microbiota
#9
Ahtesham Hussain, Mukesh Kumar Yadav, Shambhunath Bose, Jing-Hua Wang, Dongwoo Lim, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim
BACKGROUND: Obesity has become a major global health challenge due to its increasing prevalence, and the associated health risk. It is the main cause of various metabolic diseases including diabetes, hypertension, cardiovascular disease, stroke and certain forms of cancer. METHODS AND RESULTS: In the present study we evaluated the anti-obesity property of Daesiho-tang (DSHT), an herbal medicine, using high fat diet (HFD)-induced obese mice as a model. Our results showed that DSHT ameliorated body weight gain, decreased total body fat, regulated expression of leptin and adiponectin genes of adipose tissue and exerted an anti-diabetic effect by attenuating fasting glucose level and serum insulin level in HFD-fed animals...
2016: PloS One
https://www.readbyqxmd.com/read/27810046/high-density-lipoprotein-cholesterol-and%C3%A2-cause-specific-mortality-in-individuals%C3%A2-without-previous-cardiovascular-conditions-the-canheart-study
#10
Dennis T Ko, David A Alter, Helen Guo, Maria Koh, Geoffrey Lau, Peter C Austin, Gillian L Booth, William Hogg, Cynthia A Jackevicius, Douglas S Lee, Harindra C Wijeysundera, John T Wilkins, Jack V Tu
BACKGROUND: The prognostic importance of high-density lipoprotein cholesterol (HDL-C) as a specific risk factor for cardiovascular (CV) disease has been challenged by recent clinical trials and genetic studies. OBJECTIVES: This study sought to reappraise the association of HDL-C level with CV and non-CV mortality using a "big data" approach. METHODS: An observational cohort study was conducted using the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which was created by linking together 17 different individual-level data sources...
November 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27808249/apoa-i-mimetic-administration-but-not-increased-apoa-i-containing-hdl-inhibits-tumour-growth-in-a-mouse-model-of-inherited-breast-cancer
#11
Lídia Cedó, Annabel García-León, Lucía Baila-Rueda, David Santos, Victor Grijalva, Melanie Raquel Martínez-Cignoni, José M Carbó, Jari Metso, Laura López-Vilaró, Antonio Zorzano, Annabel F Valledor, Ana Cenarro, Matti Jauhiainen, Enrique Lerma, Alan M Fogelman, Srinivasa T Reddy, Joan Carles Escolà-Gil, Francisco Blanco-Vaca
Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27798951/associations-between-adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-cancer-prevention-recommendations-and-biomarkers-of-inflammation-hormonal-and-insulin-response
#12
Fred K Tabung, Teresa T Fung, Jorge E Chavarro, Stephanie A Smith-Warner, Walter C Willett, Edward L Giovannucci
Adherence to the 2007 WCRF/AICR cancer prevention recommendations has been associated with lower cancer risk but the underlying biological mechanisms have not been elucidated. We utilized dietary and lifestyle data from 11,342 women in the Nurses' Health Study and 8,136 men in the Health Professionals Follow-up Study, to investigate associations between adherence scores and markers of inflammation, hormonal and insulin response. Two scores ranging from 0 to 3 were constructed to assess adherence to the energy balance-related recommendations (weight management, physical activity, energy density); and the plant, animal foods and alcohol intake recommendations; with higher scores indicating greater adherence...
October 31, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27774064/sr-bi-linking-cholesterol-and-lipoprotein-metabolism-with-breast-and-prostate-cancer
#13
Jorge L Gutierrez-Pajares, Céline Ben Hassen, Stéphan Chevalier, Philippe G Frank
Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the progression of cancer. The SCARB1 gene encodes the scavenger receptor class B type I (SR-BI), which is an 82-kDa glycoprotein with two transmembrane domains separated by a large extracellular loop. SR-BI plays an important role in the regulation of cholesterol exchange between cells and high-density lipoproteins. Accordingly, hepatic SR-BI has been shown to play an essential role in the regulation of the reverse cholesterol transport pathway, which promotes the removal and excretion of excess body cholesterol...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27761069/influence-of-extracting-solvent-on-pharmacological-activity-and-cytotoxicity-of-polygonum-minus-a-commonly-consumed-herb-in-southeast-asia
#14
Parayil Varghese Christapher, Subramani Parasuraman, Palanimuthu Vasanth Raj, Sultan Ayesh Mohammed Saghir, Mohd Zaini Asmawi, Murugaiyah Vikneswaran
OBJECTIVE: To investigate the antihyperlipidemic, antioxidant, and cytotoxic effect of aqueous and methanol extract of leaves of Polygonum minus. MATERIALS AND METHODS: Acute antihyperlipidemic effect was studied on chemically induced hyperlipidemic rat model. Treated groups received aqueous and methanol extract of leaves of P. minus respectively (1000 mg/kg; oral) whereas standard treated group received atorvastatin (60 mg/kg; oral) for 3 consecutive days. Blood samples were collected at fixed intervals for lipid profile analysis...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27746426/serum-albumin-and-cerebro-cardiovascular-mortality-during-a-15-year-study-in-a-community-based-cohort-in-tanushimaru-a-cohort-of-the-seven-countries-study
#15
Yoko Umeki, Hisashi Adachi, Mika Enomoto, Ako Fukami, Sachiko Nakamura, Yume Nohara, Erika Nakao, Akiko Sakaue, Tomoko Tsuru, Nagisa Morikawa, Yoshihiro Fukumoto
Objective There is little long-term data on the association between the serum albumin levels and mortality in community-based populations. We aimed to determine whether the serum albumin level is an independent risk factor for all-cause and cause-specific death in a community-based cohort study in Japan. Methods In 1999, we performed a periodic epidemiological survey over a 15-year period in a population of 1,905 healthy subjects (783 males, 1,122 females) who were older than 40 years of age and who resided in Tanushimaru, a rural community, in Japan...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27729859/targeting-sr-bi-for-cancer-diagnostics-imaging-and-therapy
#16
Maneesha A Rajora, Gang Zheng
Scavenger receptor class B type I (SR-BI) plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancer cells, whereby overexpression of SR-BI has been observed in a number of tumors and cancer cell lines, including breast and prostate cancers. Consequently, SR-BI has recently gained attention as a cancer biomarker and exciting target for the direct cytosolic delivery of therapeutic agents...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27712636/diet-quality-and-mortality-risk-in-metabolically-obese-normal-weight-adults
#17
Yong-Moon Mark Park, Teresa T Fung, Susan E Steck, Jiajia Zhang, Linda J Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T Merchant
OBJECTIVE: To examine the associations among the Dietary Approaches to Stop Hypertension (DASH)-style diet, the Healthy Eating Index (HEI), and mortality risk in metabolically obese normal-weight (MONW) adults. PATIENTS AND METHODS: Data were from normal-weight (body mass index of 18.5 to <25) adults aged 30 to 90 years at baseline in the Third National Health and Nutrition Examination Survey, October 18, 1988, through October 15, 1994, followed up for deaths (all-cause, cardiovascular, and cancer related) until December 31, 2011...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27708582/high-density-lipoproteins-and-apolipoprotein-a-i-potential-new-players-in-the-prevention-and-treatment-of-lung-disease
#18
Elizabeth M Gordon, Debbie M Figueroa, Amisha V Barochia, Xianglan Yao, Stewart J Levine
Apolipoprotein A-I (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol transport out of cells. Furthermore, HDL has additional protective functions, which include anti-oxidative, anti-inflammatory, anti-apoptotic, and vasoprotective effects. In contrast, HDL can become dysfunctional with a reduction in both cholesterol efflux and anti-inflammatory properties in the setting of disease or the acute phase response. These paradigms are increasingly being recognized to be active in the pulmonary system, where apoA-I and HDL have protective effects in normal lung health, as well as in a variety of disease states, including acute lung injury (ALI), asthma, chronic obstructive pulmonary disease, lung cancer, pulmonary arterial hypertension, pulmonary fibrosis, and viral pneumonia...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27698913/pretreatment-tg-hdl-c-ratio-is-superior-to-triacylglycerol-level-as-an-independent-prognostic-factor-for-the-survival-of-triple-negative-breast-cancer-patients
#19
Danian Dai, Bo Chen, Bin Wang, Hailin Tang, Xing Li, Zhiping Zhao, Xuan Li, Xiaoming Xie, Weidong Wei
PURPOSE: Previous studies have reported that the triacylglycerol (TG) level and high-density lipoprotein cholesterol (HDL-C) are connected with breast cancer. However, the prognostic utility of the TG level and the TG/HDL-C ratio (THR) as conventional biomarkers in patients with triple negative breast cancer (TNBC) has not been elucidated. In this research, we investigate and compare the predictive value of the pretreatment serum TG level and THR in TNBC patients. METHODS: We evaluated 221 patients with TNBC who had pretreatment conventional blood biochemical examinations and calculated the THR...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27695052/ldl-cholesterol-increases-the-transcytosis-of-molecules-through-endothelial-monolayers
#20
Ana Magalhaes, Inês Matias, Inês Palmela, Maria Alexandra Brito, Sérgio Dias
Cholesterol has been identified as a causative factor in numerous pathologies including atherosclerosis and cancer. One of the frequent effects of elevated cholesterol levels in humans is the compromise of endothelial function due to activation of pro-inflammatory signalling pathways. While the mechanisms involved in endothelial activation by cholesterol during an inflammatory response are well established, less is known about the mechanisms by which cholesterol may affect endothelial barrier function, which were the subject of the present study...
2016: PloS One
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