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https://www.readbyqxmd.com/read/29907790/comparison-of-two-protocols-of-carbon-tetrachloride-induced-cirrhosis-in-rats-improving-yield-and-reproducibility
#1
José I Fortea, Carolina Fernández-Mena, Marta Puerto, Cristina Ripoll, Jorge Almagro, Juan Bañares, José M Bellón, Rafael Bañares, Javier Vaquero
Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-Dawley rats. Control rats received water instead of CCl4. Both CCl4 protocols similarly attenuated body weight gain (p < 0.01 vs. Control). Although both CCl4 protocols increased hepatic fibrosis, portal hypertension and splenomegaly, the magnitude of these alterations was higher and more consistent in CCl4-2xWk rats...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907236/peritoneal-lavage-with-povidone-iodine-solution-in-colorectal-cancer-induced-rats
#2
Hua-Li Song, Dong-Mei Zhang, Heng Wen, Meng Wang, Na Zhao, Yu-Hua Gao, Ni Ding
BACKGROUND: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model. MATERIALS AND METHODS: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29904286/utility-of-venous-blood-gases-in-severe-sepsis-and-septic-shock
#3
Heath D White, Alfredo Vazquez-Sandoval, Pedro F Quiroga, Juhee Song, Shirley F Jones, Alejandro C Arroliga
Acid-base status is frequently assessed in severe sepsis and septic shock. Venous blood gas sampling is proposed as a less-invasive modality but lacks evidence within this population. The objective of this study was to evaluate the correlation and agreement between arterial blood gas (ABG), peripheral venous blood gas (pVBG), and central venous blood gas (cVBG) in severe sepsis and septic shock. We conducted a prospective, observational cohort study in subjects admitted to the medical intensive care unit. Simultaneous blood gas samples, including ABG, pVBG, and cVBG, were analyzed for correlation and agreement...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29898239/a-novel-balloon-technique-to-induce-intra-abdominal-hypertension-and-its-effects-on-cardiovascular-parameters-in-a-conscious-dog-model
#4
Min Jang, Won-Gyun Son, Sang-Min Jo, Hyunseok Kim, Chi Won Shin, Inhyung Lee
OBJECTIVE: To evaluate a new balloon technique to induce intra-abdominal hypertension (IAH) and abdominal compartment syndrome in a conscious dog model, and to evaluate the effect of intra-abdominal pressure (IAP) on cardiovascular, respiratory, and arterial blood gas values in conscious dogs with IAH. DESIGN: Prospective, experimental study. SETTING: University-based small animal research facility. ANIMALS: Six healthy Beagle dogs, 4 males, and 2 females...
June 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29896110/plasmatic-concentrations-of-adma-and-homocystein-in-llama-lama-glama-and-regulation-of-arginase-type-ii-an-animal-resistent-to-the-development-of-pulmonary-hypertension-induced-by-hypoxia
#5
Vasthi López, Fernando A Moraga, Anibal J Llanos, German Ebensperger, María I Taborda, Elena Uribe
There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama ( Lama glama ), which seem to have developed efficient protective mechanisms to avoid maladaptation resulting from chronic hypoxia, such as a resistance to the development of hypoxia -induced pulmonary hypertension. On the other hand, it is widely known that different models of hypertension can arise as a result of changes in endothelial function. The respect, one of the common causes of deregulation in endothelial vasodilator function have been associated with down-regulation of the NO synthesis and an increase in plasma levels of asymmetric dimethylarginine (ADMA) and homocysteine...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29891211/effective-thiafentanil-immobilization-and-physiological-responses-of-free-ranging-moose-alces-alces-in-northern-sweden
#6
Daniela Sb Barros, Alina L Evans, Jon M Arnemo, Fredrik Stenbacka, Göran Ericsson
OBJECTIVE: To evaluate clinical and physiological responses in moose to thiafentanil administration for immobilization. STUDY DESIGN: Cross-sectional clinical study. ANIMALS: Eleven (six males and five females) free-ranging adult moose (Alces alces). METHODS: Each moose was darted from a helicopter with 7.5 mg thiafentanil during March 2014 in northern Sweden. Physiological evaluation included vital signs and blood gases...
March 31, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29862306/effects-of-human-relaxin-2-serelaxin-on-hypoxic-pulmonary-vasoconstriction-during-acute-hypoxia-in-a-sheep-model
#7
René Schiffner, Marius Nistor, Sabine Juliane Bischoff, Georg Matziolis, Martin Schmidt, Thomas Lehmann
Purpose: Hypoxia induces pulmonary vasoconstriction with a subsequent increase of pulmonary artery pressure (PAP), which can result in pulmonary hypertension. Serelaxin has shown an increase of pulmonary hemodynamic parameters after serelaxin injection. We therefore investigated the response of pulmonary hemodynamic parameters after serelaxin administration in a clinically relevant model. Methods: Six controls and six sheep that received 30 μg/kg serelaxin underwent right heart catheterization during a 12-minute hypoxia period (inhalation of 5% oxygen and 95% nitrogen) and subsequent reoxygenation...
2018: Hypoxia
https://www.readbyqxmd.com/read/29813077/underlying-mechanism-of-subcortical-brain-protection-during-hypoxia-and-reoxygenation-in-a-sheep-model-influence-of-%C3%AE-1-adrenergic-signalling
#8
René Schiffner, Sabine Juliane Bischoff, Thomas Lehmann, Florian Rakers, Sven Rupprecht, Georg Matziolis, Harald Schubert, Matthias Schwab, Otmar Huber, Cornelius Lemke, Martin Schmidt
While the cerebral autoregulation sufficiently protects subcortical brain regions during hypoxia or asphyxia, the cerebral cortex is not as adequately protected, which suggests that regulation of the cerebral blood flow (CBF) is area-specific. Hypoxia was induced by inhalation of 5% oxygen, for reoxygenation 100% oxygen was used. Cortical and subcortical CBF (by laser Doppler flowmetry), blood gases, mean arterial blood pressure (MABP), heart rate and renal blood flow were constantly monitored. Low dosed urapidil was used for α1A-adrenergic receptor blockade...
2018: PloS One
https://www.readbyqxmd.com/read/29805256/the-effects-of-home-oxygen-therapy-on-energy-metabolism-in-patients-with-copd
#9
Nurcan Kırıcı Berber, Özkan Yetkin, Talat Kılıç, Ilhami Berber, Mehmet Özgel
Background: COPD is preventable and treatable and is characterized by completely nonreversible airflow obstruction. In this study, we aimed to investigate the effect of long-term oxygen therapy on patients with stage 4 COPD who were followed up and treated at the polyclinic or clinic service. We evaluated the effects of oxygen therapy on energy metabolism and physical activity in patients with COPD. Methods: Nineteen patients with COPD (16 male/3 female), treated with oxygen therapy for the first time, were included in this study...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29804882/induction-of-anesthesia-and-recovery-in-donkeys-sedated-with-xylazine-a-comparison-of-midazolam-alfaxalone-and-midazolam-ketamine
#10
Jill K Maney, H Edward Durham, Kathleen P Goucher, Erika L Little
OBJECTIVE: To compare the induction and recovery characteristics and selected cardiopulmonary variables of midazolam-alfaxalone or midazolam-ketamine in donkeys sedated with xylazine. STUDY DESIGN: Randomized, blinded, crossover experimental trial. ANIMALS: A group of seven adult male castrated donkeys weighing 164 ± 14 kg. METHODS: Donkeys were randomly administered midazolam (0.05 mg kg-1 ) and alfaxalone (1 mg kg-1 ) or midazolam (0...
April 16, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29797212/comparison-of-subcutaneous-insulin-aspart-and-intravenous-regular-insulin-for-the-treatment-of-mild-and-moderate-diabetic-ketoacidosis-in-pediatric-patients
#11
Zahra Razavi, Saba Maher, Javad Fredmal
PURPOSE: To compare the safety/efficacy of intermittent subcutaneous rapid-acting insulin aspart with the standard low-dose intravenous infusion protocol of regular insulin for treatment of pediatric diabetic-ketoacidosis. METHODS: For a prospective randomized-controlled clinical trial on 50 children/adolescents with mild/moderate diabetic-ketoacidosis, the diagnostic criteria for ketoacidosis included: blood glucose level >250 mg/dl, ketonuria>++, venous pH <7...
May 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29765003/passive-versus-active-circuit-during-invasive-mechanical-ventilation-in-subjects-with-amyotrophic-lateral-sclerosis
#12
Elisa De Mattia, Elisa Falcier, Andrea Lizio, Christian Lunetta, Valeria A Sansone, Nicola Barbarito, Barbara Garabelli, Marino Iatomasi, Elisabetta Roma, Fabrizio Rao, Annalisa Carlucci
BACKGROUND: Until recently, it has been considered essential to maintain the use of a double-limb circuit in patients with amyotrophic lateral sclerosis (ALS) to avoid rebreathing expired air during invasive mechanical ventilation. Currently, life-sustaining home ventilators can work with a single, lighter circuit that is easier to manage. Our aim was to evaluate the effectiveness and safety of a single-limb circuit with intentional leaks (passive circuit) in comparison with a circuit with an expiratory valve (active circuit), in subjects with ALS who use invasive home ventilation...
May 15, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29743094/feasibility-and-safety-of-low-flow-extracorporeal-co-2-removal-managed-with-a-renal-replacement-platform-to-enhance-lung-protective-ventilation-of-patients-with-mild-to-moderate-ards
#13
Matthieu Schmidt, Samir Jaber, Elie Zogheib, Thomas Godet, Gilles Capellier, Alain Combes
BACKGROUND: Extracorporeal carbon-dioxide removal (ECCO2 R) might allow ultraprotective mechanical ventilation with lower tidal volume (VT) (< 6 ml/kg predicted body weight), plateau pressure (Pplat ) (< 30 cmH2 O), and driving pressure to limit ventilator-induced lung injury. This study was undertaken to assess the feasibility and safety of ECCO2 R managed with a renal replacement therapy (RRT) platform to enable very low tidal volume ventilation of patients with mild-to-moderate acute respiratory distress syndrome (ARDS)...
May 10, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29742984/maternal-serum-endocan-concentration-in-pregnancies-complicated-by-intrauterine-growth-restriction
#14
Agata Szpera-Gozdziewicz, Katarzyna Kosicka, Tomasz Gozdziewicz, Mariola Krzyscin, Przemyslaw Wirstlein, Anna Siemiatkowska, Franciszek Glowka, Ewa Wender-Ozegowska, Grzegorz H Breborowicz
OBJECTIVES: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis. Therefore, this study aimed to investigate the relationship between maternal endocan serum level and intrauterine growth restriction (IUGR) as well as ultrasound Doppler flow measurements indicating placental insufficiency. METHODS: This study included a group of women with IUGR (n = 37) and a group of healthy pregnant women (controls, n = 37)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29739856/accuracy-of-transcutaneous-co-2-values-compared-with-arterial-and-capillary-blood-gases
#15
Laura L Lambert, Melissa B Baldwin, Cruz Velasco Gonzalez, Gary R Lowe, J Randy Willis
BACKGROUND: Transcutaneous monitors are utilized to monitor a patient's respiratory status. Some patients have similar values when comparing transcutaneous carbon dioxide ( P tcCO2 ) values with blood gas analysis, whereas others show extreme variability. A retrospective review of data was performed to determine how accurately P tcCO2 correlated with CO2 values obtained by arterial blood gas (ABG) or capillary blood gas. METHODS: To determine whether P tcCO2 values correlated with ABG or capillary blood gas values, subjects' records were retrospectively reviewed...
May 8, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29734208/improved-lung-recruitment-and-oxygenation-during-mandatory-ventilation-with-a-new-expiratory-ventilation-assistance-device-a-controlled-interventional-trial-in-healthy-pigs
#16
Johannes Schmidt, Christin Wenzel, Marlene Mahn, Sashko Spassov, Heidi Cristina Schmitz, Silke Borgmann, Ziwei Lin, Jörg Haberstroh, Stephan Meckel, Sebastian Eiden, Steffen Wirth, Hartmut Buerkle, Stefan Schumann
BACKGROUND: In contrast to conventional mandatory ventilation, a new ventilation mode, expiratory ventilation assistance (EVA), linearises the expiratory tracheal pressure decline. OBJECTIVE: We hypothesised that due to a recruiting effect, linearised expiration oxygenates better than volume controlled ventilation (VCV). We compared the EVA with VCV mode with regard to gas exchange, ventilation volumes and pressures and lung aeration in a model of peri-operative mandatory ventilation in healthy pigs...
May 4, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29710689/pulmonary-hemodynamic-effects-and-pulmonary-arterial-compliance-during-hypovolemic-shock-and-reinfusion-with-human-relaxin-2-serelaxin-treatment-in-a-sheep-model
#17
René Schiffner, Thomas Lehmann, Sabine J Bischoff, Timo Zippelius, Marius Nistor, Martin Schmidt
BACKGROUND: Previous studies on the recombinant form of human relaxin-2 (serelaxin) have shown a decrease of pulmonary hemodynamics after serelaxin injection. Currently, the effect of serelaxin treatment during hypovolemia in a large animal model remains mostly unknown. METHODS: 12 sheep were randomly assigned to a sham or serelaxin (30μg/kg serelaxin) group and underwent right heart catheterization. 50% of the estimated total blood volume were removed to induce hypovolemia, and subsequently retransfused 20 min later (reinfusion)...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29701248/carotid-body-activity-are-we-eating-our-way-into-the-ventilatory-pathway
#18
Hannah Leverton, Cailey England, Ashtyn Baxandall
Maintenance of the partial pressure of arterial O2 and CO2 blood gases (PaO2 and PaCO2 , respectively) is coordinated through two distinct, but interacting chemoreflex feedback loops. This article is protected by copyright. All rights reserved.
April 27, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29652271/prophylactic-preoperative-levosimendan-for-off-pump-coronary-artery-bypass-grafting-in-patients-with-left-ventricular-dysfunction-single-centered-randomized-prospective-study
#19
Pushkar Mahendra Desai, Manjula S Sarkar, Sanjeeta R Umbarkar
Background: Off-pump coronary artery bypass surgery (OPCAB) is often complicated by hemodynamic instability, especially in patients with prior left ventricular (LV) dysfunction and appropriate choice of inotrope plays a vital role in perioperative management of these patients. Aim and Objective: To study hemodynamic effects and immediate outcome of prophylactic infusion of levosimendan in patients with the LV dysfunction undergoing OPCAB surgery and whether this strategy helps in successful conduct of OPCAB surgery...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29649316/effect-of-one-lung-ventilation-on-end-tidal-carbon-dioxide-during-cardiopulmonary-resuscitation-in-a-pig-model-of-cardiac-arrest
#20
Dong Hyun Ryu, Yong Hun Jung, Kyung Woon Jeung, Byung Kook Lee, Young Won Jeong, Jong Geun Yun, Dong Hun Lee, Sung Min Lee, Tag Heo, Yong Il Min
Unrecognized endobronchial intubation frequently occurs after emergency intubation. However, no study has evaluated the effect of one-lung ventilation on end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR). We compared the hemodynamic parameters, blood gases, and ETCO2 during one-lung ventilation with those during conventional two-lung ventilation in a pig model of CPR, to determine the effect of the former on ETCO2. A randomized crossover study was conducted in 12 pigs intubated with double-lumen endobronchial tube to achieve lung separation...
2018: PloS One
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