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Tripanosoma cruzi

Camila França Campos, Silvia Dantas Cangussú, Ana Luiza Cassin Duz, Christiane Teixeira Cartelle, Maria de Lourdes Noviello, Vanja Maria Veloso, Maria Terezinha Bahia, Camila Megale Almeida-Leite, Rosa Maria Esteves Arantes
We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in order to develop the chronic phase of infection with low parasitism as in human disease. A group of Swiss mice was infected with the Y strain of T...
2016: PloS One
Dioxelis López, Lilia Cherigo, Carmenza Spadafora, Marco A Loza-Mejía, Sergio Martínez-Luis
BACKGROUND: Panama has an extensive mangrove area and it is one of the countries with the highest biodiversity in America. Mangroves are widely used in traditional medicine, nevertheless, there are very few studies that validates their medicinal properties in America. Given the urgent need for therapeutic options to treat several diseases of public health importance, mangrove ecosystem could be an interesting source of new bioactive molecules. This study was designed to evaluate the potential of Pelliciera rhizophorae as a source of bioactive compounds...
December 2015: Chemistry Central Journal
Bárbara Alicia Novelo-Garza, Gamaliel Benítez-Arvizu, América Peña-Benítez, Jorge Galván-Cervantes, Alejandro Morales-Rojas
BACKGROUND: The American trypanosomiasis is the second parasitic disease in importance after paludism and one of the main mechanism of transmission is a blood transfusion. Our objective was to measure the effect the Tripanosoma Cruzi screening test in blood banks in the Mexican Institute of Social Security. METHODS: Information was obtained from each unit of blood collected. The Tripanosoma cruzi prevalence was calculated only in samples with double reactivity in the blood banks...
March 2010: Revista Médica del Instituto Mexicano del Seguro Social
Fumiko Satoh, Hiroshi Tachibana, Iwao Hasegawa, Motoki Osawa
Chagas disease is a tropical disease that is prevalent in Latin America. Described herein is an autopsy case of the sudden death of a 48-year-old Brazilian man who had stayed in Japan for 7 years. The man, who had a history of Chagas disease, collapsed unexpectedly at work. Because the cause of death was unknown, forensic autopsy examination was performed. As gross findings, the heart was dilated and rounded with an increase in size and weight. The esophagus and large intestine were dilated moderately, with extensive interstitial inflammatory infiltration in the cardiac muscle, but no apparent parasite nest was observed in various tissues...
March 2010: Pathology International
Vanessa S A Barbosa, Cecília M C X Holanda, Antônia C J Câmara, Roseane P Silva, Daniel P Oliveira, Jeanete A Moreira, Aldo C Medeiros
With the aim of investigating the biodistribution of technetium-99m pertechnetate ((99m)TcO4-) in rats infected with Y strain of Tripanosoma Cruzi, at the peak of parasitemia, (14th day of infection), we injected Wistar rats with 0.1 ml of (99m)TcO4- (3.7MBq). After 60 min, the percentage of radioactivity per gram was counted in several isolated organs and blood, using a gamma counter (1470 Wizard, PerkinElmer Finland). The uptake of (99m)TcO4- increased significantly in blood and decreased in the colon of infected animals (p<0...
December 2009: Experimental Parasitology
Nicolás Pedrini, Sergio J Mijailovsky, Juan R Girotti, Raúl Stariolo, Rubén M Cardozo, Alberto Gentile, M Patricia Juárez
BACKGROUND: Triatoma infestans-mediated transmission of Tripanosoma cruzi, the causative agent of Chagas disease, remains as a major health issue in southern South America. Key factors of T. infestans prevalence in specific areas of the geographic Gran Chaco region-which extends through northern Argentina, Bolivia, and Paraguay-are both recurrent reinfestations after insecticide spraying and emerging pyrethroid-resistance over the past ten years. Among alternative control tools, the pathogenicity of entomopathogenic fungi against triatomines is already known; furthermore, these fungi have the ability to fully degrade hydrocarbons from T...
2009: PLoS Neglected Tropical Diseases
Juan Venegas, William Coñoepan, Sergio Pichuantes, Sandra Miranda, María Isabel Jercic, Marta Gajardo, Gittith Sánchez
To better understand the evolution of the etiologic agent of Chagas disease, we cloned and sequenced 25 alleles from five Tripanosoma cruzi microsatellite markers. The study of the sequences showed highly conserved alleles present in T. cruzi clones belonging to TCI, TCIIc, and TCIIe. This result was also confirmed by the phylogenetic analysis of MCLE01 allele sequences. The examination by capillary electrophoresis of six microsatellite markers from 19 T. cruzi clones showed a high proportion of the alleles found both in the TCI and TCII sublineages...
July 2009: Parasitology Research
Luciana Lopes, Lyris M F Godoy, Carolina C de Oliveira, Juarez Gabardo, Ruth J G Schadeck, Dorly de Freitas Buchi
Canova is a homeopathic medication with immunomodulatory properties, recommended for diseases where the immune system is depressed. Our research aims to study the activation of mice peritoneal macrophages when submitted to in vivo and in vitro Canova treatment. Morphological parameters and acid phosphatase activity were analyzed using light and transmission electron microscopy. Differential interference contrast microscopy, including serial time acquisition in living cells, was also performed. The results demonstrated a greater spreading ability in Canova treated macrophages, a higher phagocytic activity of non-infective microorganisms (Saccharomyces cerevisiae and Tripanosoma cruzi epimastigotes) and a tendency to lower the phagocytic activity of the infective microorganisms T...
2006: Micron: the International Research and Review Journal for Microscopy
I Zwir, R Romero Zaliz, E H Ruspini
Recent advances in the accessibility of databases containing representations of complex objects-exemplified by repositories of time-series data, information about biological macromolecules, or knowledge about metabolic pathways-have not been matched by availability of tools that facilitate the retrieval of objects of particular interest and aid understanding their structure and relations. In applications, such as the analysis of DNA sequences, on the other hand, requirements to retrieve objects on the basis of qualitative characteristics are poorly met by descriptions that emphasize precision and detail rather than structural features...
December 2002: Annals of the New York Academy of Sciences
G J Sibona, C A Condat
We study the dynamics of a model that describes the competitive interaction between an invading species (a parasite) and its antibodies in an living being. This model was recently used to examine the dynamical competition between Tripanosoma cruzi and its antibodies during the acute phase of Chagas' disease. Depending on the antibody properties, the model yields three types of outcomes, corresponding, respectively, to healing, chronic disease, and host death. Here, we study the dynamics of the parasite-antibody interaction with the help of simulations, obtaining phase trajectories and phase diagrams for the system...
March 2002: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
M V Introini, B Basso, E Moretti
In previous works it has been demonstrated that Balb/c albino mice immunized with Trypanosoma rangeli developed cellular and humoral immune response to Tripanosoma cruzi. Moreover, the immunized animals were protected against lethal infection by virulent T. cruzi trypomastigotes. In fact, immunized mice had significantly lower parasitemias and longer survival than controls. To go further in this experimental model, the aim of the present work was to analyze the effect of the number of antigenic stimuli and the conservation of the antigen on the effectiveness of protective effect...
July 1998: Boletín Chileno de Parasitología
J de D Mendoza González, E Miranda Lluck, O Velazco Castrejón, O Tinoco Reyna, M de J Maciel Pérez
In a general hospital located in the southern Pacific coast of Mexico, an endemic area for Chagas' disease, we performed a survey among people attending the outpatient Cardiology clinic. From 8640 patients we selected 158 who had potential exposure to Triatomine bugs, the vector of Tripanosoma cruzi. Sixty patients had: congestive heart failure or abnormal cardiac rythm or conduction defects. All of them had evidence for anti T. cruzi antibodies. A diagnosis of chronic Chagasic cardiopathy (CCC) was established...
November 1995: Archivos del Instituto de Cardiología de México
I Caracelli, F M Stamato, B Mester, M Paulino, H Cerecetto
1-¿[(5-Nitro-2-furyl)methylene]amino¿-1,2,4-triazole, C7H5N5O3, is a new analogue of nifurtimox with activity against Tripanosoma cruzi. In the crystal structure, the molecule lies on a mirror plane and has an E-sZ conformation along the N = C-C moiety. The molecules are linked through C-H...O and C-H...N interactions.
May 15, 1996: Acta Crystallographica. Section C, Crystal Structure Communications
M P Barretto, A F de Siqueira, F Ferriolli Filho, J da R Carvalheiro, R D Albuquerque, G K Funayama
No abstract text is available yet for this article.
June 1968: Revista Brasileira de Biologia
S Hung Rico
No abstract text is available yet for this article.
1972: Acta Científica Venezolana
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