keyword
https://read.qxmd.com/read/38508331/an-urticarial-rash-fevers-and-arthralgias
#1
Colton H Funkhouser, Oluwakemi Onajin, Arlene M Ruiz de Luzuriaga, Amy Z Xu
No abstract text is available yet for this article.
March 18, 2024: American Journal of Medicine
https://read.qxmd.com/read/38482975/low-ph-condition-impairs-bp-igg-binding-to-the-basement-membrane-zone
#2
JOURNAL ARTICLE
Dongjun Im, Keisuke Ueda, Hirofumi Niwa, Kayoko Tanaka, Hiroaki Iwata
Bullous pemphigoid (BP), an autoimmune subepidermal blistering disease, shows tense blisters associated with urticarial erythema. Tissue-bound Immunoglobulin G (IgG) at the basement membrane zone (BMZ) detected by direct immunofluorescence (DIF) is strong evidence for a diagnosis of BP. The sensitivity of DIF is higher in complement component 3 (C3) than in IgG, but the reason for this different sensitivity is not fully understood. In this study, we performed several ex vivo studies to investigate the possible mechanism of IgG negativity and C3 positivity at the BMZ by DIF in some BP cases...
March 14, 2024: Journal of Dermatology
https://read.qxmd.com/read/38445235/hereditary-angioedema-with-normal-c1-inhibitor-associated-with-carboxypeptidase-n-deficiency
#3
JOURNAL ARTICLE
Denis Vincent, Faidra Parsopoulou, Ludovic Martin, Christine Gaboriaud, Jacques Demongeot, Gedeon Loules, Sascha Fischer, Sven Cichon, Anastasios E Germenis, Arije Ghannam, Christian Drouet
BACKGROUND: Hereditary angioedema (HAE) is a potentially life-threatening disorder characterized by recurrent episodes of subcutaneous or submucosal swelling. HAE with normal C1 inhibitor (HAE-nC1-INH) is an underdiagnosed condition. Although the association with genetic variants has been identified for some families, the genetic causes in many patients with HAE-nC1-INH remain unknown. The role of genes associated with bradykinin catabolism is not fully understood. OBJECTIVE: We sought to investigate the biological parameters and the genes related to kallikrein-kinin system in families with a clinical phenotype of HAE-nC1-INH and presenting with a carboxypeptidase N (CPN) deficiency...
May 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38423683/neutrophilic-urticarial-dermatosis
#4
REVIEW
Amarachi Orakwue, Jeremy Bray, Nneka Comfere, Olayemi Sokumbi
Neutrophilic urticarial dermatosis (NUD) is a rare form of dermatosis that is poorly understood. It was first described by Kieffer and colleagues as an urticarial eruption that is histopathologically characterized by a perivascular and interstitial neutrophilic infiltrate with intense leukocytoclasia and without vasculitis or dermal edema. NUD clinically presents as a chronic or recurrent eruption that consists of nonpruritic macules, papules, or plaques that are pink to reddish and that resolve within 24 hours without residual pigmentation...
April 2024: Dermatologic Clinics
https://read.qxmd.com/read/38394514/evaluation-of-short-term-adverse-events-of-covid-19-vaccines-an-observational-study
#5
JOURNAL ARTICLE
Fatemeh Fathi, Ali Ameri, Omid Safa, Mehdi Hassaniazad, Mohammad Fathalipour
Coronavirus disease 2019 (COVID-19) vaccines are the most effective tools in managing the pandemic. However, the concern about these vaccines is the occurrence of unwanted adverse events (AEs). This study aimed to evaluate the short-term AEs of COVID-19 vaccines (Sputnik V, Astrazenka, and Sinopharm). A cross-sectional study using an online questionnaire was conducted among 321 vaccinated individuals. Demographic information, history of drug use, prior infection with COVID-19, the type of vaccine, vaccination stage, local injection site complication, systemic complication, and allergic reactions were collected and evaluated...
February 23, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38354006/-hereditary-systemic-autoinflammatory-diseases-associated-with-cryopyrin
#6
JOURNAL ARTICLE
Bénédicte Neven
HEREDITARY SYSTEMIC AUTOINFLAMMATORY DISEASES ASSOCIATED WITH CRYOPYRIN. CAPS (cryoprine-associated periodic syndromes) are a group of auto-inflammatory diseases of varying severity, most often beginning very early in life and characterized by febrile episodes, a pseudo-urticarial skin rash, joint manifestations and inconstantly neurosensory involvement. These symptoms may be intermittent and triggered by cold exposure but can also be chronic. Cryopyrinopathies are associated with heterozygous, gain-of-function mutations in NLRP3...
October 2023: La Revue du Praticien
https://read.qxmd.com/read/38304855/b-cell-acute-lymphoblastic-leukemia-associated-with-hypereosinophilia-a-case-report-and-brief-literature-review
#7
Sahar Khosravi, Khatereh Mousavi-Fatemi, Pouyan Ebrahimi, Mohammad Barary, Terence T Sio, Ali Tavakoli Pirzaman
Few cases of B-cell acute lymphoblastic leukemia (B-ALL)-eosinophilia (ALL-eo) association have been reported. The lack or absence of blasts in the peripheral blood smear (PBS) along with urticarial rash, fever, arthralgia, myalgia, sweating, and dyspnea are common features of this condition. Herein, we report a 16-year-old male patient admitted to the emergency department with urticaria and generalized itching. PBS was examined, and eosinophils (90%) were seen in different fields. However, blast cells were not seen in PBS...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38298760/interesting-mucocutaneous-manifestations-in-covid-19-infection-or-vaccination-confirmed-by-histopathology-a-case-series
#8
JOURNAL ARTICLE
Arash Pour Mohammad, Elahe Noroozi, Milad Gholizadeh Mesgarha, Nasrin Shayanfar, Azadeh Goodarzi
INTRODUCTION: Mucocutaneous complications or adverse events due to SARS-CoV-2 infection or vaccination have been well delineated in the literature, respectively. Most eruptions are considered mild and self-limiting; however, for the atypical cases with a tentative clinical diagnosis, performing a biopsy and histopathological assessment is pivotal to confirm the diagnosis and subsequently prescribe a more tailored treatment. Despite the diverse reporting of such incidents globally, most studies restrict the rate of biopsied cases to less than 15%...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38298324/a-case-report-of-systemic-allergic-reaction-to-the-dual-glucose-dependent-insulinotropic-polypeptide-glucagon-like-peptide-1-receptor-agonist-tirzepatide
#9
Trang Thi Bich Le, Le Huu Nhat Minh, Pooja Devi, Nabila Islam, Issac Sachmechi
This report examines a case of systemic hypersensitivity to tirzepatide in a patient with type 2 diabetes. Tirzepatide (Mounjaro®), a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor, has recently gained FDA approval. Additionally, a literature review was conducted to summarize recent research on tirzepatide's effectiveness and safety. A 67-year-old woman, previously treated with basal insulin, metformin, and semaglutide (a GLP-1 agonist), experienced severe disseminated pruritus and a generalized urticarial rash after her first dose of tirzepatide...
January 2024: Curēus
https://read.qxmd.com/read/38235773/-not-available
#10
JOURNAL ARTICLE
Jasmin Bagge, Kristine Freude, Casper Lindegaard, Bjørn Holst, Per Hölmich
Intraarticular treatment of osteoarthritis with mesenchymal stem cells (MSCs) has shown promising results and is being increasingly implemented in the clinic. Autologous MSCs are the primary source of therapy but issues related to cell expansion, patient age, and acute therapies have opened a need for allogenic MSCs. Problematic immunological reactions such as pain, joint swelling, urticarial, and MSC destruction are, however, reported when using allogenic MSCs at the first to second treatment. Multiple factors need to be considered when deciding on autologous or allogenic MSC treatment, as argued in this review...
January 1, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38214726/-urticarial-dermatitis-with-blister-formation
#11
JOURNAL ARTICLE
Nicole Gherghel, Kristin Technau-Hafsi, Maja Mockenhaupt, Kilian Eyerich, Christoph M Schempp
No abstract text is available yet for this article.
January 12, 2024: Dermatologie (Heidelb)
https://read.qxmd.com/read/38193233/tick-bites-ige-to-galactose-alpha-1-3-galactose-and-urticarial-or-anaphylactic-reactions-to-mammalian-meat-the-alpha-gal-syndrome
#12
REVIEW
Jeffrey M Wilson, Loren Erickson, Michael Levin, Samuel M Ailsworth, Scott P Commins, Thomas A E Platts-Mills
The recent recognition of a syndrome of tick-acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non-primate mammals. Thus, fittingly, this allergic disorder is now called the alpha-gal syndrome (AGS). The syndrome is strikingly regional, reflecting the important role of tick bites in sensitization, and is more common in demographic groups at risk of tick exposure...
January 9, 2024: Allergy
https://read.qxmd.com/read/38180923/early-cutaneous-manifestations-of-covid-19-a-systematic-review-and-public-health-implications
#13
REVIEW
Abhinav Grover, Franchesca Choi, Sheng-Pei Wang
INTRODUCTION: Cutaneous manifestations before other symptoms have great potential for early COVID-19 diagnosis to prevent surge. METHODS: We conducted a search of PubMed and Embase databases through April 11, 2021 to include 39 studies reporting skin manifestations occurring prior to any other COVID-19 symptoms in laboratory-confirmed cases. RESULTS: Ninety-seven patients were included. Urticarial (24.7%) and maculopapular (22.7%) lesions were most common, followed by pernio (17...
December 2023: WMJ: Official Publication of the State Medical Society of Wisconsin
https://read.qxmd.com/read/38173049/a-rare-case-of-dialysis-associated-reaction-presenting-with-urticarial-vasculitis-and-haemoglobinuria
#14
Varadharajan Jayaprakash, Gerry George Mathew, Suganya Muthukarupiah, Sreedhar Sailapathy, Ramachandran Ramakrishnan
Dialysis associated reactions presenting with urticarial vasculitis is rarely reported in medical literature. We report a 61-year-old gentleman who developed sudden onset dyspnea with diffuse erythema within 20 min of haemodialysis. Patient was started on Azilsartan 3 days prior to this clinical event. Labs revealed features of hemolysis and urine was positive for hemoglobinuria. All dialysis related factors responsible for this reaction were ruled out. Due to non-resolution of skin rash, skin biopsy was attempted which revealed fibrinoid necrosis of occasional vessels with predominant lymphocytic infiltration suggestive of drug induced urticarial vasculitis...
January 3, 2024: Nephrology
https://read.qxmd.com/read/38162407/a-case-of-urticarial-vasculitis-associated-with-atezolizumab
#15
Jade N Young, Ryan Rivera-Oyola, Dina Poplausky, Yamato Suemitsu, Randie H Kim, Deborah Doroshow, Nicholas Gulati
No abstract text is available yet for this article.
January 2024: JAAD Case Reports
https://read.qxmd.com/read/38153627/toxicity-spectrum-of-anti-gd2-immunotherapy-a-real-world-study-leveraging-the-us-food-and-drug-administration-adverse-event-reporting-system
#16
JOURNAL ARTICLE
Guangfei Wang, Jinglin Wang, Ruxiang Du, Yi Wang, Zhiping Li
BACKGROUND: Anti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma, yet their toxicity spectrum is unclear. OBJECTIVE: This study aimed to assess the toxicity profiles of three anti-GD2 monoclonal antibodies (dinutuximab, dinutuximab β, and naxitamab) in clinical applications by mining and evaluating the adverse drug reaction (ADR) signals from the US Food and Drug Administration Adverse Event Reporting System...
December 28, 2023: Paediatric Drugs
https://read.qxmd.com/read/38142684/online-depiction-of-urticaria-is-often-flawed-and-does-not-reflect-the-spectrum-of-clinical-manifestation
#17
JOURNAL ARTICLE
Ditte Georgina Zhang, Jennifer Astrup Sørensen, Nadja Højgaard Pedersen, Zarqa Ali, Emek Kocatürk, Marcus Maurer, Simon Francis Thomsen
BACKGROUND: The internet is a popular source of health information including images of disease manifestations. Online photographs of skin lesions may aid patients in identifying their disease, if these pictures are of good quality and of the disease they claim to show. If not, patients may be at risk of delayed diagnosis, misdiagnosis, and suboptimal treatment. For urticaria, the mismatch rate and quality of online pictures are unknown. The objective of this study was therefore to evaluate the content and quality of online images of urticaria...
December 23, 2023: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/38123643/embryonic-stem-cell-derived-mesenchymal-stem-cells-relieve-experimental-contact-urticaria-by-regulating-the-functions-of-mast-cells-and-t-cells
#18
JOURNAL ARTICLE
Seung Yeun Hyun, Eun-Young Kim, Minseong Kang, Jeong Won Park, Ki-Sung Hong, Hyung-Min Chung, Wahn Soo Choi, Se-Pill Park, Geunwoong Noh, Hyuk Soon Kim
Contact urticaria (CU) is an inflammatory skin disorder triggered by specific substances upon skin contact, leading to immediate acute or chronic manifestations characterized by swelling and redness. While mesenchymal stem cells (MSCs) are increasingly recognized for their therapeutic potential in immune diseases, research on the efficacy and mechanisms of stem cell therapy for urticaria remains scarce. This study investigates the regulatory role of embryonic-stem-cell-derived multipotent MSCs (M-MSCs) administered in a CU mouse model...
December 20, 2023: Scientific Reports
https://read.qxmd.com/read/38094286/the-added-on-of-ziziphus-jujube-syrup-in-the-treatment-of-chronic-spontaneous-urticaria-resistant-to-standard-dose-of-secondary-generation-h-1-antihistamine-a-double-blind-randomized-clinical-trial
#19
JOURNAL ARTICLE
Hamid Zare, Seyed Hesamedin Nabavizdeh, Amir Mohamad Jaladat, Mohamad Mehdi Zarshenas, Mozhgan Moghtaderi, Atefeh Basirat, Nahid Nasri
BACKGROUND: Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of Ziziphus jujube fruit syrup in combination with antihistamines was assessed in patients with CSU. METHODS: This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020. 64 patients with CSU who had experienced hives for at least six weeks and did not respond to the usual treatments were enrolled in the study...
November 2023: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38090411/a-rare-case-of-digital-ulceration-and-gangrene-as-an-initial-presentation-of-systemic-lupus-erythematosus-in-a-child
#20
Shyam Vengala, Varnika Gupta, Vaishnavi Kandukuri, Bala Sai Teja Nuthalapati, Navya Pillikunte Doddareddy, Deepanshu Raj, Mihirkumar P Parmar, Vishal Venugopal
Systemic lupus erythematosus (SLE) is a complex autoimmune illness with a wide range of symptoms. Tissue-binding autoantibodies and intricate immune complexes are responsible for the initial damage to organs and cellular structures. Dermatological signs, particularly digital gangrene and ulcers, are uncommon in the context of systemic lupus erythematosus and often appear in the advanced stages of the disease. In this discussion, we present an unusual example of early-onset digital gangrene and ulcers in a young kid with systemic lupus erythematosus...
November 2023: Curēus
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