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https://www.readbyqxmd.com/read/28440920/pediatric-pulmonology-year-in-review-2016-part-2
#1
REVIEW
Richard Auten, Clement Ren, Ozge Yilmaz, Terry L Noah
Pediatric Pulmonology continues to publish research and clinical topics related to the entire range of children's respiratory disorders. As we have done annually in recent years, we here summarize some of the past year's publications in our major topic areas, as well as selected literature in these areas from other core journals relevant to our discipline. This review (Part 2) covers selected articles on neonatology, asthma, physiology and lung function testing, and infectious diseases.
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28219747/is-pulmonary-diffusion-capacity-for-nitric-oxide-dl-no-likely-to-become-a-routine-pulmonary-function-test
#2
Irene Steenbruggen, Frans de Jongh
DL,CO measurements are often used to evaluate and monitor lung diseases as well as cardiovascular diseases. Whether the combination of DL,CO and DL,NO will improve the management of cardiovascular diseases needs to be investigated. It is hoped that the standardization of the DL,NO measurement will facilitate research. Scientific evidence that DL,NO can provide more accurate information than DL,CO alone, can take away the barriers that prevents DL,NO to become a routine test in pulmonology.
February 17, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28025241/clinical-tools-to-assess-asthma-control-in-children
#3
Chitra Dinakar, Bradley E Chipps
Asthma affects an estimated 7 million children and causes significant health care and disease burden. The most recent iteration of the National Heart, Lung and Blood Institute asthma guidelines, the Expert Panel Report 3, emphasizes the assessment and monitoring of asthma control in the management of asthma. Asthma control refers to the degree to which the manifestations of asthma are minimized by therapeutic interventions and the goals of therapy are met. Although assessment of asthma severity is used to guide initiation of therapy, monitoring of asthma control helps determine whether therapy should be maintained or adjusted...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27922234/long-term-azithromycin-therapy-in-patients-with-cystic-fibrosis
#4
Nagehan Emiralioğlu, Zeynelabidin Öztürk, Ebru Yalçın, Deniz Doğru, Uğur Özçelik, Nural Kiper
Inflammation is a central contributor to the pathogenesis of cystic fibrosis (CF) pulmonary disease; so limiting the excessive production of inflammatory mediators represents a major therapeutic strategy for slowing the decline in lung function and improving survival. The macrolide antibiotic azithromycin (AZM) has anti-inflammatory properties and immunomodulatory effects that may be beneficial in CF. The aim of this study was to document the long term use of AZM effect on pulmonary function, nutritional status and number of pulmonary exacerbations in patients with CF...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27870227/aspergillosis-and-the-role-of-mucins-in-cystic-fibrosis
#5
REVIEW
Abigail C Cowley, David J Thornton, David W Denning, Alexander Horsley
The prevalence of aspergillosis in CF patients has until recently been underestimated, but increasing evidence suggests that it may play an important role in the progression of CF lung disease. In healthy airways, Aspergillus fumigatus can be efficiently removed from the lung by mechanisms such as mucociliary clearance and cough. However, these mechanisms are defective in CF, allowing pathogens such as A. fumigatus to germinate and establish chronic infections within the airways. The precise means by which A...
April 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27865240/prediction-equations-for-spirometry-in-adults-in-western-india
#6
Unnati Desai, Jyotsna M Joshi, S K Chhabra, Mujeeb-Ur Rahman
BACKGROUND: Spirometry is an essential investigation in pulmonology. The predicted normal spirometry values depend on various physiological parameters. This study was conducted to collect updated information on pulmonary functions in normal adults from western India. MATERIAL AND METHODS: A prospective observational study was undertaken at a tertiary hospital in Mumbai enrolling healthy subjects, 18-75 years, with ethnic origin from western India. Spirometry measurements were carried out as per ATS/ERS-2005 guidelines using a non-heated Fleish Pneumotachograph spirometer...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27742871/assessing-bronchodilator-response-in-preschool-children-using-spirometry
#7
Luciano E Busi, Sebastián Restuccia, Ricardo Tourres, Peter D Sly
BACKGROUND: Measuring lung function, including bronchodilator response (BDR), is an integral part of asthma management in older children. While spirometry is possible in preschool-aged children, the question remains whether measuring BDR aids in asthma diagnosis in this age group. METHODS: 431 healthy children and 289 children with asthma, aged 3-5 years, were recruited from kindergartens and the pulmonology clinic in Trelew, Argentina. Spirometry was performed at visit 1 and repeated after 15 min, with children randomised to placebo or salbutamol (400 µg)...
April 2017: Thorax
https://www.readbyqxmd.com/read/27717725/airway-tone-dysfunction-among-pre-schoolers-with-positive-asthma-predictive-index-a-case-control-study
#8
V Lezana, A Gajardo, L Bofill, M Gutierrez, S Mora, J A Castro-Rodriguez
OBJECTIVE: To measure lung function by impulse oscillometry (IOS) and spirometry in recurrent wheezer pre-schoolers according to their asthma predictive index (API) condition. METHODS: We performed a case-control study enrolling all pre-schoolers with recurrent wheezing episodes (>3 episodes confirmed by physician) who presented at a paediatric pulmonology clinic. The population was divided according to stringent API criteria into positive or negative. RESULTS: In the nine-month period, 109 pre-schoolers were enrolled...
March 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27614793/novel-and-powerful-3d-adaptive-crisp-active-contour-method-applied-in-the-segmentation-of-ct-lung-images
#9
Pedro Pedrosa Rebouças Filho, Paulo César Cortez, Antônio C da Silva Barros, Victor Hugo C Albuquerque, João Manuel R S Tavares
The World Health Organization estimates that 300 million people have asthma, 210 million people have Chronic Obstructive Pulmonary Disease (COPD), and, according to WHO, COPD will become the third major cause of death worldwide in 2030. Computational Vision systems are commonly used in pulmonology to address the task of image segmentation, which is essential for accurate medical diagnoses. Segmentation defines the regions of the lungs in CT images of the thorax that must be further analyzed by the system or by a specialist physician...
September 5, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#10
EDITORIAL
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27562904/a-long-term-follow-up-investigation-of-endobronchial-valves-in-emphysema-the-live-study-study-protocol-and-six-month-interim-analysis-results-of-a-prospective-five-year-observational-study
#11
Dirk Skowasch, Andreas Fertl, Björn Schwick, Harald Schäfer, Andreas Hellmann, Felix J F Herth
BACKGROUND: Randomized controlled trials indicate that significant lung volume reduction (ELVR) can be obtained with Zephyr® valves by occluding the target lobe in the absence of collateral ventilation, leading to relevant functional benefits in advanced emphysema patients. OBJECTIVES: To observe the long-term effects of endobronchial valve (EBV) implantation in emphysema patients screened by Chartis assessment in the context of daily pulmonology practice. METHODS: The LIVE Study is a prospective, observational, open-label, single-arm, multicenter trial conducted in Germany...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27470706/health-related-quality-of-life-in-patients-with-%C3%AE-1-antitrypsin-deficency-a-cross-sectional-study
#12
Margarida Torres Redondo, Elsa Campoa, Luis Ruano, Maria Sucena
BACKGROUND: Measures of health related quality of life (HRQoL) in patients with α1-antitrypsin deficiency (AATD) can help to determine the impact of the disease and provide an important insight into the intervention outcomes. There is few data regarding this issue in the literature. The aim of this study is to assess the relationship between HRQoL and gender, functional parameters and history of hospitalizations in patients with AATD. METHODS: This is a cross-sectional study of 26 patients with severe AATD recruited in the pulmonology outpatient clinic at a tertiary care medical center...
February 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27401776/new-aspect-for-systemic-effects-of-copd-eye-findings
#13
Erhan Ugurlu, Gokhan Pekel, Goksel Altinisik, Kerem Bozkurt, Ilknur Can, Fatma Evyapan
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) has multisystemic implications and comorbidities. Hypoxia and systemic inflammation are thought to involve oculary structures. In this study, our aim is to evaluate retinal nerve fiber and choroidal thickness and retinal vessel diameter using the Spectral-domain optical coherence tomography (SD-OCT) in COPD subjects. METHODS: 43 subjects diagnosed with COPD according to the Chronic Obstructive Lung Disease criteria at the Pulmonology Department of Pamukkale University were enrolled in the study...
July 12, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27237592/executive-summary-of-the-separ-recommendations-for-the-diagnosis-and-treatment-of-non-small-cell-lung-cancer
#14
Felipe Villar Álvarez, Ignacio Muguruza Trueba, José Belda Sanchis, Laureano Molins López-Rodó, Pedro Miguel Rodríguez Suárez, Julio Sánchez de Cos Escuín, Esther Barreiro, M Henar Borrego Pintado, Carlos Disdier Vicente, Javier Flandes Aldeyturriaga, Pablo Gámez García, Pilar Garrido López, Pablo León Atance, José Miguel Izquierdo Elena, Nuria M Novoa Valentín, Juan José Rivas de Andrés, Íñigo Royo Crespo, Ángel Salvatierra Velázquez, Luís M Seijo Maceiras, Segismundo Solano Reina, David Aguiar Bujanda, Régulo J Avila Martínez, Jose Ignacio de Granda Orive, Eva de Higes Martinez, Vicente Diaz-Hellín Gude, Raúl Embún Flor, Jorge L Freixinet Gilart, María Dolores García Jiménez, Fátima Hermoso Alarza, Samuel Hernández Sarmiento, Antonio Francisco Honguero Martínez, Carlos A Jimenez Ruiz, Iker López Sanz, Andrea Mariscal de Alba, Primitivo Martínez Vallina, Patricia Menal Muñoz, Laura Mezquita Pérez, María Eugenia Olmedo García, Carlos A Rombolá, Iñigo San Miguel Arregui, María de Valle Somiedo Gutiérrez, Ana Isabel Triviño Ramírez, Joan Carles Trujillo Reyes, Carmen Vallejo, Paz Vaquero Lozano, Gonzalo Varela Simó, Javier J Zulueta
The Thoracic Surgery and Thoracic Oncology groups of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) have backed the publication of a handbook on recommendations for the diagnosis and treatment of non-small cell lung cancer. Due to the high incidence and mortality of this disease, the best scientific evidence must be constantly updated and made available for consultation by healthcare professionals. To draw up these recommendations, we called on a wide-ranging group of experts from the different specialties, who have prepared a comprehensive review, divided into 4 main sections...
July 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27000811/-acceptance-of-the-disease-in-patients-with-lung-cancer
#15
Bożena Karczmarek-Borowska, Monika Tobiasz, Agnieszka Bukała
UNLABELLED: Lung cancer is the most common malignancy in men and the second frequent in women. Cancer is not without consequences on the life and functioning of a patient. The process of adopting the disease is based on restoring the patient's psychological balance, reduction of the emotional discomfort and self-confidence. AIM: The aim of the study was to assess the acceptance of lung cancer in patients with this diagnosis. MATERIALS AND METHODS: The study included 73 patients treated at the Pulmonology Ward of Podkarpackie Center for Lung Diseases, Department of Clinical Oncology of Podkarpackie Oncology Centre in Rzeszów and at the Department of Chemotherapy, Radiotherapy and Oncological Surgery of Podkarpackie Oncological Center in Brzozów...
February 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26796331/severe-asthma-features-in-children-a-case-control-online-survey
#16
MULTICENTER STUDY
Silvia Montella, Eugenio Baraldi, Salvatore Cazzato, Raffaele Aralla, Mariangela Berardi, Luigia Maria Brunetti, Fabio Cardinale, Renato Cutrera, Fernando Maria de Benedictis, Emanuela di Palmo, Sabrina Di Pillo, Grazia Fenu, Stefania La Grutta, Enrico Lombardi, Giorgio Piacentini, Francesca Santamaria, Nicola Ullmann, Franca Rusconi
BACKGROUND: Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. METHODS: We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6-17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma...
January 22, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26793344/biopsy-testing-in-an-inoperable-non-small-cell-lung-cancer-population-a-retrospective-real-life-study-in-sweden
#17
Hirsh Koyi, Leif Johansson, Jesper From, Sven Nyrén
BACKGROUND: Correct diagnosis and staging are required for optimal treatment choice in lung cancer patients. This retrospective, patient medical records study investigated the clinical practice of lung cancer biopsy procedures and testing in Sweden. METHODS: Consecutive patients with a recorded inoperable, malignant tumour of bronchus and lung were retrospectively identified at geographically widespread pulmonology clinics (NCT01139619). Data, including diagnostic sampling methodology [bronchoscopy, biopsy by pulmonologist and computed tomography (CT)-guided biopsy], were collected for patients diagnosed between 1 June 2009-31 May 2010, and analysed using descriptive statistics...
December 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26428583/recommendations-for-the-use-of-endoscopic-lung-volume-reduction-in-south-africa-role-in-the-treatment-of-emphysema
#18
Coenraad F N Koegelenberg, Johan Theron, Keertan Dheda, J Willie Bruwer, Brian W Allwood, Morné J Vorster, Florian von Groote-Bidlingmaier, Dirk-Jan Slebos, Pallav L Shah, Felix J F Herth
Emphysema is a very common cause of morbidity and mortality in South Africa (SA). Therapeutic options in severe emphysema are limited. Endoscopic lung volume reduction (ELVR) is increasingly being used internationally for the treatment of advanced emphysema in a subset of patients with advanced disease, aiming to obtain the same functional advantages as surgical lung volume reduction while reducing risks and costs. In addition to endobronchial valves, ELVR using endobronchial coils is now available in SA. The high cost of these interventions underscores the need for careful patient selection to best identify those who may or may not benefit from ELVR-related procedures...
October 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/26229565/amyloidosis-involving-the-respiratory-system-5-year-s-experience-of-a-multi-disciplinary-group-s-activity
#19
Raffaele Scala, Uberto Maccari, Chiara Madioni, Duccio Venezia, Lidia Calogera La Magra
Amyloidosis may involve the respiratory system with different clinical-radiological-functional patterns which are not always easy to be recognized. A good level of knowledge of the disease, an active integration of the pulmonologist within a multidisciplinary setting and a high level of clinical suspicion are necessary for an early diagnosis of respiratory amyloidosis. The aim of this retrospective study was to evaluate the number and the patterns of amyloidosis involving the respiratory system. We searched the cases of amyloidosis among patients attending the multidisciplinary rare and diffuse lung disease outpatients' clinic of Pulmonology Unit of the Hospital of Arezzo from 2007 to 2012...
July 2015: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/26124850/case-of-seropositive-allergic-bronchopulmonary-aspergillosis-in-a-10-year-old-girl-without-previously-documented-asthma
#20
Jeong Eun Shin, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was referred to the Department of Pediatric Pulmonology for persistent consolidations on chest radiography. Pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with a 4-week prescription of broad-spectrum antibiotics. The patient had a history of atopic dermatitis and allergic rhinitis but no history of asthma...
May 2015: Korean Journal of Pediatrics
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