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https://www.readbyqxmd.com/read/29691639/a-blind-area-of-origins-of-epistaxis-technical-or-cognitive
#1
Wei Wei, Yuting Lai, Chaoping Zang, Jiqin Luo, Bijun Zhu, Quan Liu, Ying Liu
PURPOSE: To investigate common origins and features of anterior epistaxis. METHODS: Patients (168) with anterior nose bleed were studied from May to October 2013. Endoscopic examination with angled endoscope and then subsequent management (radiofrequency, selective packing,) was performed. RESULTS: Under thorough nasal endoscopy, anterior nasal bleeding origin was ranked in turn as follows: the anterior nasal septum (NS 83.3%), the small area of anterior lateral wall of nasal cavity corresponding to the nasal back (NB 7...
April 24, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29687426/-diagnosis-and-treatment-of-osler-s-disease
#2
F Haubner, T Kühnel
Osler's disease is an autosomal dominant hereditary syndrome which belongs to the group of orphan diseases. Affected patients suffer primarily from severe epistaxis. Diagnosis is based on the Curaçao criteria and molecular genetic tests. Organ manifestations can be found in the form of arteriovenous shunts in the lung, liver, and gastrointestinal tract; more rarely also in the central nervous system (CNS) and other parts of the body. Many patients with gastrointestinal and other organ manifestations are frequently clinically asymptomatic; therefore, organ screening is essential to avoid later complications and should be performed in centers with particular expertise...
April 23, 2018: HNO
https://www.readbyqxmd.com/read/29683824/a-randomized-trial-comparing-the-effect-of-fiberoptic-selection-and-guidance-versus-random-selection-blind-insertion-and-direct-laryngoscopy-on-the-incidence-and-severity-of-epistaxis-after-nasotracheal-intubation
#3
Jeffrey Leighton Tong, Avery Tung
BACKGROUND: Epistaxis, or nasal bleeding, is a common complication after nasotracheal intubation (NTI). Because such bleeding is likely related to trauma during intubation, use of fiberoptic visualization and guidance rather than direct laryngoscopy may affect the incidence and severity of epistaxis. We compared the incidence of epistaxis after NTI using a fiberoptic versus a direct laryngoscopy approach. METHODS: Seventy patients who were able to breathe easily through unobstructed nostrils and required NTI as part of their anesthetic management were recruited...
April 19, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676168/transnasal-endoscopic-sphenopalatine-artery-ligation-compared-with-embolization-for-intractable-epistaxis-a-long-term-analysis
#4
G de Bonnecaze, Y Gallois, F Bonneville, S Vergez, B Chaput, E Serrano
Background Transnasal endoscopic sphenopalatine artery ligation (TESPAL) and selective embolization both provide excellent treatment success rate in the management of intractable epistaxis. Few long-term studies comparing these approaches have been previously published. Recommendations often present these techniques as alternatives, but there is no clear consensus. Objective The purpose of this study was to evaluate and compare the clinical efficacy of sphenopalatine artery ligation versus embolization to control intractable epistaxis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29666086/endonasal-endoscopic-laser-assisted-resection-of-septal-glomangiopericytoma
#5
Sana Sheikh, Fatima Sarwar, Naqeeb Ullah Khan, Muhammad Sarwar Khan
Glomangiopericytoma is a rare vascular neoplasm characterised by a pattern of prominent perivascular growth with myoid phenotype. It is categorised as a borderline low-malignancy tumour by WHO and accounts for less than 0.5% of all sinonasal tumours. After curative resection, patients of glomangiopericytoma need long-term endoscopic follow-up due to high risk of recurrence.We report a case of a 23-year-old man complaining of nasal obstruction off and on and frequent epistaxis. A reddish mass in the right nasal cavity was observed on endoscopy and treated with endoscopic excision...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29662934/bevacizumab-for-refractory-gastrointestinal-bleeding-in-rendu-osler-weber-disease
#6
Carlos Bernardes, Sara Santos, Rafaela Loureiro, Verónica Borges, Gonçalo Ramos
Rendu-Osler-Weber disease, also known as hereditary hemorrhagic telangiectasia, is a rare autosomal dominant disorder which is often characterized by recurrent epistaxis, mucocutaneous and gastrointestinal telangiectasias, and visceral arteriovenous malformations. Patients with gastrointestinal involvement can present with a wide spectrum of severity, which may vary from uncomplicated iron deficiency anemia to continuous and refractory bleeding. We present the case of a 62-year-old female, who was admitted with anemia following several episodes of melena, and whose endoscopic examination revealed multiple angiodysplasias in the stomach and small bowel...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29657686/extraskeletal-myxoid-chondrosarcoma-of-nasopharynx-an-oncologic-entity-rarely-reported
#7
Abhishek Purkayastha, Neelam Sharma, Vibha Dutta
Extraskeletal myxoid chondrosarcoma (ESMC) is an extremely rare variant of chondrosarcoma accounting for less than 10% cases. It affects mainly the soft tissues of the proximal end of long bones. Its incidence in the head and neck region is less than 5%. This case presented in the nasopharynx, an exceedingly unusual site for ESMC in a 60-year-old female with left-sided nasal obstruction and occasional epistaxis of one-year duration. Biopsy from the nasopharyngeal mass was suggestive of low-grade chondrosarcoma...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29629052/cosmic-rays-as-a-novel-hypothetic-explanation-for-the-ancient-mentioned-effects-of-sleeping-under-the-night-sky
#8
Farshad Amini-Behbahani, Jafar Ghafarzadeh
Traditional medicine scientists believed that sleeping under the stars and moonlight is not healthy because it brings about nose bleeds and respiratory problems. In Avicenna's view, the spirit and its tendency to the light are introduced as main etiology, which cannot explain star light as a proper etiology. In modern knowledge, it seems cosmic rays that reach our planet's atmosphere by electron cascade, play a key role. Internal organs' electrical charge distribution disturbance caused by these electrons can lead to irregular spasms in the muscular walls of arteries and other organs...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29626372/bleeding-related-hospitalization-in-patients-with-von-willebrand-disease-and-the-impact-of-prophylaxis-results-from-national-registers-in-sweden-compared-with-normal-controls-and-participants-in-the-von-willebrand-disease-prophylaxis-network
#9
E Holm, K Steen Carlsson, S Lövdahl, A E Lail, T C Abshire, E Berntorp
INTRODUCTION: Patients suffering from von Willebrand disease (VWD) have a variety of bleeding symptoms and require both outpatient care for treatment and, in more severe cases, hospitalization. AIM: To investigate the impact of having VWD on frequency of hospitalization compared to a control group and to evaluate whether regular replacement therapy (prophylaxis) is associated with reduction in the number of hospitalizations. METHODS: Linkage of national population-based registries was used in the Congenital Bleeding Disorders study in Sweden (CBDS)...
April 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29624770/hot-off-the-press-topical-tranexamic-acid-compared-with-anterior-nasal-packing-for-treatment-of-epistaxis-in-patients-taking-antiplatelet-drugs
#10
Justin Morgenstern, Sahaana Rangarajan, Corey Heitz, Chris Bond, William K Milne
This is a non-blinded, randomized controlled trial comparing topical TXA and anterior nasal packing in the treatment of anterior epistaxis in patients on antiplatelet medications whose bleeding persisted despite 20 minutes of pressure. Patients were randomized to either TXA (a cotton pledget soaked with 500 mg of TXA and inserted into the affected nostril until hemostasis was achieved) or anterior nasal packing (pretreatment with a cotton pledget soaked in epinephrine and 2% lidocaine for 10 minutes followed by anterior nasal packing with tetracycline ointment left in situ for 3 days)...
April 6, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29620646/multiple-metastases-of-clear-cell-renal-cell-carcinoma-to-different-region-of-the-nasal-cavity-and-paranasal-sinus-3-times-successively-a-case-report-and-literature-review
#11
Na Zhang, Bing Zhou, Qian Huang, Xiaohong Chen, Shunjiu Cui, Zhenxiao Huang, Yan Sun
RATIONALE: Distant metastasis of clear-cell renal cell carcinoma (ccRCC) to the nasal cavity and paranasal sinus is rare. Endoscopic biopsy used to be performed for diagnosis when it is difficult for complete resection due to intense bleeding during surgery. According to previous literature, the outcomes of metastasis after endoscopic surgery remain unclear. PATIENT CONCERNS: A 62-year-old man with a history of epistaxis was referred to our institution. The clinical, computed tomography (CT) and magnetic resonance imaging (MRI) examination indicate metastasis to sinonasal sinuses...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29616317/outcomes-of-patients-with-myelofibrosis-treated-with-compassionate-use-pacritinib-a-sponsor-independent-international-study
#12
J Mascarenhas, E Virtgaym, M Stal, H Blacklock, A T Gerds, R Mesa, P Ganly, D Snyder, I Tabbara, D Tremblay, E Moshier
Myelofibrosis (MF) is a chronic yet progressive myeloid neoplasm in which only a minority of patients undergo curative therapy, hematopoietic stem cell transplantation. Ruxolitinib, a JAK1/2 inhibitor, is the lone therapy approved for MF, offering a clear symptom and spleen benefit at the expense of treatment-related cytopenias. Pacritinib (PAC), a multi-kinase inhibitor with specificity for JAK2, FLT3, and IRAK1 but sparing JAK1, has demonstrated clinical activity in MF with minimal myelosuppression. Due to an FDA-mandated full clinical hold, the randomized phase 3 PERSIST trials were abruptly stopped and PAC was immediately discontinued for all patients...
April 3, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29602670/topical-tranexamic-acid-for-the-treatment-of-acute-epistaxis-in-the-emergency-department
#13
Asha R Birmingham, Nathan D Mah, Ran Ran, Matthew Hansen
OBJECTIVE: To evaluate the effectiveness and potential benefits of topical tranexamic acid (TXA) in the management of acute epistaxis. METHODS: Retrospective review was performed among all patients presenting to the institution's emergency department (ED) with epistaxis between September 2014 and August 2016. Patients achieving hemostasis with standard of care agents, such as oxymetazoline, lidocaine, or epinephrine were excluded. The primary outcome was the ED length of stay (LOS)...
March 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29600317/septal-branches-of-the-anterior-ethmoidal-artery-anatomical-considerations-and-clinical-implications-in-the-management-of-refractory-epistaxis
#14
Mario Turri-Zanoni, Alberto Daniele Arosio, Aldo Cassol Stamm, Paolo Battaglia, Giovanni Salzano, Antonio Romano, Paolo Castelnuovo, Frank Rikki Canevari
PURPOSE: Epistaxis is a commonly presenting complaint. In severe cases, nosebleeds may occur despite antero-posterior nasal packing and often in the absence of identifiable sources of bleeding. In such cases, epistaxis may occur from septal branches of the anterior ethmoidal artery (sbAEA). The purposes of this study are to highlight the clinical role of the sbAEA in different fields of endoscopic endonasal surgery and to evaluate the efficacy and safety of their selective endoscopic endonasal ligation in the management of refractory epistaxis...
March 29, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29592986/pleomorphic-adenoma-of-nasal-septum-a-rare-case
#15
Shama Shetty, Dipak Ranjan Nayak, Padmapriya Jaiprakash
The most common benign tumour of the major salivary glands is the pleomorphic adenoma. They are seen rarely in the minor salivary glands, usually in hard palate, soft palate and nasopharynx. Pleomorphic adenomas in nasal cavity are unusual and may be misdiagnosed because they have predominant myoepithelial cellularity and fewer myxoid stromata compared with those elsewhere. We present a case of 38-year-old male with a 2-year history of left nasal obstruction and epistaxis since 6 months. Diagnostic nasal endoscopic examination showed a soft lobulated mass in left nasal cavity attached to anterior part of the septum...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29588890/endoscopic-transsphenoidal-salvage-surgery-for-symptomatic-residual-cystic-craniopharyngioma-after-radiotherapy
#16
Enzo Emanuelli, Giuliana Frasson, Diego Cazzador, Daniele Borsetto, Luca Denaro
Objectives  Ideal treatment of craniopharyngiomas is still controversial. Radiotherapy (RT) is considered effective for recurrences or after subtotal tumor removal (STR). About 40 to 50% of patients may experience tumor cyst expansion soon after RT; in these cases, the role of salvage surgery is debated. Design  Operative video. Setting  Tertiary care center. Participants  An 11-year-old boy diagnosed with persistent craniopharyngioma. In 2015, the patient underwent right frontotemporal craniotomy for STR at another center, complicated by panhypopituitarism...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29578356/an-unusual-case-of-hematemesis-and-epistaxis-caused-by-a-pheochromocytoma
#17
Kader Ugur, Mustafa Girgin, İbrahim Halil Bahcecioglu, Hakan Artas, Fikri Selcuk Simsek, Suleyman Aydin
Pheochromocytoma is a rare catecholamine-secreting neoplasm that is the cause of hypertension in <0.2% of patients with hypertension. We encountered an unusual case of pheochromocytoma involving hematemesis and epistaxis episodes with accompanying hypertensive attacks. Venous ectasia was detected in the esophagus. Abdominal magnetic resonance imaging revealed an adenoma in the left adrenal region. The present case illustrates that pheochromocytoma can mimic different clinical conditions.
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29573771/radiofrequency-for-treatment-of-refractory-epistaxis-in-hereditary-hemorrhagic-telangiectasia
#18
Mariana Donato, João Pimentel, Rui Cabral, Pedro Escada
Hereditary hemorrhagic telangiectasia is a rare multi-systemic autosomal dominant disorder characterized by dysplasia of the vascular connective tissue and recurrent bleeding tendency. Epistaxis is the most common and earliest symptom. It is usually mild to moderate, however, in some patients it can be severe with significant interference in quality of life. We report a case of a patient with hereditary hemorrhagic telangiectasia, in which an episode of refractory epistaxis was treated with radiofrequency and fibrin sealant...
January 31, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29557421/hemorrhagic-events-in-adult-celiac-disease-patients-case-report-and-review-of-the-literature
#19
Alina Dima, Ciprian Jurcut, Anca Manolache, Daniel Vasile Balaban, Alina Popp, Mariana Jinga
BACKGROUND AND AIMS: Celiac disease (CD) presents with a wide spectrum of extra-digestive symptoms, including hemorrhagic manifestations. The aim of this review was to conduct an extensive analysis of the hemorrhagic events reported in adult CD patients. METHODS: Case report and review of the literature. Pubmed (MEDLINE) database search from January 1970 onwards was performed using the medical subject headings [MeSH] terms "celiac disease" AND "blood coagulation disorders", "hemorrhage", "hematoma", "hematuria", "hemoptysis", "epistaxis", "hemosiderosis"...
March 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29554974/renal-dialysis-and-long-term-treatment-of-a-dog-with-kidney-disease-associated-with-canine-leishmaniosis
#20
Gad Baneth, Gilad Segev, Michal Mazaki-Tovi, Hila Chen, Sharon Kuzi
BACKGROUND: Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal amyloidosis. Proteinuria is a frequent finding in canine leishmaniosis and its quantification by the urine protein-creatinine ratio (UPC) is an important parameter in the staging of canine lesihmaniosis as presented by the LeishVet group...
March 20, 2018: Parasites & Vectors
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