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Gidion Edwin, Francis Msagati, Francisca Komanya, Baraka Alphonce, John Meda, Azan Nyundo
KEY CLINICAL MESSAGE: Neuromyelitis optica spectrum disorder is an autoimmune disease, rarely presents with antiphospholipid syndrome. Diagnosis and management of NMOSD are challenging in the background of diverse presentations, especially in resource-limited settings. ABSTRACT: Neuromyelitis optica spectrum disorder (NMOSD) is a progressive demyelinating autoimmune condition resulting from the autoantibodies produced against aquaporin-4 (AQP-4) proteins which are widely distributed in astrocytes in the nervous system...
May 2024: Clinical Case Reports
#2
JOURNAL ARTICLE
Rebeca Rosa de Souza, Mayckel da Silva Barreto, Elen Ferraz Teston, Maria Aparecida Salci, Viviane Cazetta de Lima Vieira, Sonia Silva Marcon
OBJECTIVE: to learn the meanings attributed to pregnancy loss by women with Lupus. METHOD: qualitative research, based on Symbolic Interactionism and Grounded Theory. Data collection took place between January and August 2022 through in-depth interviews. Data analysis went through the stages of initial and focused coding. RESULTS: seventeen women participated. The central phenomenon "The climb to motherhood: falls and overcoming" was constructed, consisting of three categories: "Falling to the ground during the climb: the experience of pregnancy loss"; "Getting up and following the path: new attempts to conceive"; and "Remembering the journey: meanings attributed to pregnancy losses"...
2024: Revista Brasileira de Enfermagem
#3
JOURNAL ARTICLE
Enitome E Bafor, Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E Kimmel, Olivier Duverger, John M Fenimore, Meredith Ramba, Thea Spindel, Megan M Hess, Michael Sanford, Vanja Lazarevic, Bérénice A Benayoun, Howard A Young, Julio C Valencia
INTRODUCTION: Interferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility. Additionally, the underlying immunological mechanisms remain elusive. METHODS: Here, we explore the impact of systemic IFN-γ elevation on cytotoxic T cell responses in female reproduction utilizing a systemic lupus-prone mouse model with impaired IFN-γ degradation...
2024: Frontiers in Immunology
#4
JOURNAL ARTICLE
Elsy Aidé García-Villegas, Cruz Vargas-de-León, Antonio Rafael Villa-Romero, Itzelly Ibarra Valdovinos, Horacio Márquez-González
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have an increased risk of metabolic syndrome (MS) and cardiovascular (CV) disease. MS is evaluated binary, limiting the understanding of each component's severity individually. Therefore, severity scores for MS that evaluate them separately have been developed. This study aims to determine the prognosis between MS severity and the occurrence of major adverse cardiovascular events (MACE) in SLE patients. METHODS: Ten-year follow-up cohort study...
May 1, 2024: Medicina Clínica
#5
JOURNAL ARTICLE
Ji-Ning Jia, Xian-Li Wang
Introduction: We investigated trends in the use of therapeutic drugs for pregnant patients with rheumatic diseases in nine Chinese cities (Beijing, Chengdu, Guangzhou, Harbin, Hangzhou, Shanghai, Shenyang, Tianjin, and Zhengzhou) to provide a reference for drug use in clinic. Methods: Outpatient prescription data for pregnant patients diagnosed with rheumatic diseases in nine cities across China in 2016-2021 were extracted from the Hospital Prescription Cooperation Project of the Hospital Pharmacy Professional Committee of the Chinese Pharmaceutical Association...
2024: Frontiers in Pharmacology
#6
JOURNAL ARTICLE
Ahmed H Al-Jedai, Hajer Y Almudaiheem, Ibrahim A Al-Homood, Ibrahim Almaghlouth, Sami M Bahlas, Abdulaziz Mohammed Alolaiw, Mohammad Fatani, Maysa Tariq Eshmawi, Bedor A AlOmari, Khalidah Ahmed Alenzi, Rayan G Albarakat, Nayef Al Ghanim
OBJECTIVE: To provide evidence-based clinical practice recommendations for managing Systemic Lupus Erythematosus (SLE) in Saudi Arabia. METHODS: This EULAR-adapted national guideline in which a multidisciplinary task force utilized the modified Delphi method to develop 31 clinical key questions. A systematic literature review was conducted to update the evidence since the EULAR publication. After reaching a consensus agreement, two rounds of voting and group discussion were conducted to generate consolidated recommendations/statements...
April 30, 2024: Current Rheumatology Reviews
#7
JOURNAL ARTICLE
Candido Muñoz Muñoz, Filipa Farinha, Thomas McDonnell, Hajar Jbari, Hanh Nguyen, David Isenberg, Anisur Rahman, David Williams, Jaume Alijotas-Reig, Ian Giles
BACKGROUND: Females diagnosed with systemic lupus erythematosus (SLE) face an elevated risk of adverse pregnancy outcomes (APOs). However, the evidence regarding whether a similar association exists in patients with undifferentiated connective tissue disease (UCTD) is inconclusive. METHODS: We conducted a retrospective review (2006-2019) of pregnancy outcomes among patients with SLE (n = 51) and UCTD (n = 20) within our institution. We examined the occurrence of various APOs, encompassing miscarriage, stillbirth, termination, preterm birth, pre-eclampsia, eclampsia, HELLP syndrome, intrauterine growth restriction, abruption placentae, congenital heart block, or other cardiac abnormalities...
April 24, 2024: Revista Clínica Espanõla
#8
MULTICENTER STUDY
Laura Andreoli, Maria Chiara Gerardi, Maria Gerosa, Davide Rozza, Francesca Crisafulli, Roberta Erra, Daniele Lini, Laura Trespidi, Melissa Padovan, Francesca Ruffilli, Francesca Serale, Giovanna Cuomo, Bernd Raffeiner, Paolo Semeraro, Chiara Tani, Maria Sole Chimenti, Paola Conigliaro, Ariela Hoxha, Cecilia Nalli, Micaela Fredi, Maria Grazia Lazzaroni, Matteo Filippini, Marco Taglietti, Franco Franceschini, Sonia Zatti, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Cristina Zanardini, Giulia Fontana, Giorgia Gozzoli, Claudia Barison, Paola Bizioli, Roberto Felice Caporali, Giulia Carrea, Manuela Wally Ossola, Beatrice Maranini, Ettore Silvagni, Marcello Govoni, Danila Morano, Rosita Verteramo, Andrea Doria, Teresa Del Ross, Maria Favaro, Antonia Calligaro, Marta Tonello, Maddalena Larosa, Margherita Zen, Alessandra Zambon, Marta Mosca, Dina Zucchi, Elena Elefante, Sabrina Gori, Florenzo Iannone, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Salvatore D'Angelo, Maria Stefania Cutro, Valentina Picerno, Teresa Carbone, Angela Anna Padula, Patrizia Rovere-Querini, Valentina Canti, Rebecca De Lorenzo, Ludovica Cavallo, Véronique Ramoni, Carlomaurizio Montecucco, Veronica Codullo, Alessandra Milanesi, Giulia Pazzola, Giuseppina Comitini, Chiara Marvisi, Carlo Salvarani, Oscar Massimiliano Epis, Sara Benedetti, Giuseppina Di Raimondo, Clizia Gagliardi, Claudia Lomater, Gloria Crepaldi, Elisa Bellis, Francesca Bellisai, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, Maria Letizia Urban, Irene Mattioli, Annamaria Iuliano, Giandomenico Sebastiani, Antonio Luca Brucato, Emanuele Bizzi, Maurizio Cutolo, Leonardo Santo, Sara Tonetta, Gianpiero Landolfi, Greta Carrara, Alessandra Bortoluzzi, Carlo Alberto Scirè, Angela Tincani
OBJECTIVES: To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. METHODS: Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. RESULTS: We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19...
April 24, 2024: RMD Open
#9
JOURNAL ARTICLE
Shuming Shao, Yimin Zhang, Jie Liu, Zheng Liu, Xiaorui Zhang
BACKGROUND: In recent years, China has adjusted its fertility policies to optimize the population structure by implementing the two-child and three-child policies. Some patients with systemic lupus erythematosus (SLE) are considering the possibility of having a second child. The issue is whether the offspring from the second childbirth will have favorable long-term developmental outcomes. OBJECTIVE: The research aims to investigate the long-term physical, neurological, and social-emotional development outcomes of children born to mothers with SLE at different parities...
April 6, 2024: Early Human Development
#10
JOURNAL ARTICLE
İbrahim Vasi, Derya Yıldırım, Rıza Can Kardaş, Burcugül Kaya, Rahime Duran, Gizem Tuğçe Alp, Hazan Karadeniz, Aslıhan Avanoğlu Güler, Hamit Küçük, Berna Göker, Abdurrahman Tufan, Mehmet Akif Öztürk, Abdulsamet Erden
OBJECTIVES: To evaluate the use of calcineurin inhibitors (CNIs), specifically tacrolimus, in unplanned pregnancies with active lupus disease among patients with systemic lupus erythematosus (SLE). MATERIALS AND METHODS: The study includes data from pregnancies in women diagnosed with SLE at Gazi University Hospital in Ankara, Türkiye, between January 2010 and July 2022. The study categorized pregnancies into planned and unplanned groups based on lupus nephritis presence, emphasizing the need for inactive lupus disease for at least 6 months before attempting conception in planned pregnancies...
April 12, 2024: International Journal of Clinical Pharmacology and Therapeutics
#11
JOURNAL ARTICLE
Xueyan Li, Jiandi Wu, Feifei Fang, Ying Liu, Wewei Jiang, Gangping Li, Jun Song
The mortality rate of gastric varices bleeding can reach 20% within 6 weeks. Isolated gastric varices (IGVs) refer to gastric varices without esophageal varices and typically arise as a common complication of left portal hypertension. Although IGVs commonly form in the setting of splenic vein occlusion, the combination of antiphospholipid syndrome and protein S deficiency leading to splenic vein occlusion is rare. We herein present a case of a 28-year-old woman with intermittent epigastric pain and melena. She was diagnosed with antiphospholipid syndrome based on the triad of pregnancy morbidity, unexplained venous occlusion, and positive lupus anticoagulant...
April 2024: Journal of International Medical Research
#12
JOURNAL ARTICLE
Paloma Vela-Casasempere, Rocío Caño Alameda, Silvia Gómez Sabater, Silvia Cortell Aznar, Encarnación Pérez Pascual
OBJECTIVE: To share our experience with belimumab in lupus pregnant women and to review the relevant published literature on its use in this scenario. METHODS: A prospective observational study of pregnant patients with lupus was conducted. Additionally, MEDLINE and EMBASE databases were searched, and a secondary hand search of the literature was performed. Studies were evaluated and visualised descriptively. RESULTS: Sixteen pregnancies of 12 lupus women were included, six (involving eight pregnancies) received belimumab throughout their illness, five of them during some period of gestation...
April 9, 2024: Lupus
#13
JOURNAL ARTICLE
Tabassum Elahi, Saima Ahmed, Muhammed Mubarak, Ejaz Ahmed
BACKGROUND: Pregnancy in women with systemic lupus erythematosus (SLE) has remained a great challenge for clinicians in terms of maternal and fetal outcomes. The outcomes in women with pre-existing lupus nephritis (LN) are variable. The impact of different classes of LN on maternal and fetal outcomes during pregnancy is not well defined, as data is very scarce, especially from the developing countries. METHODS: A retrospective analysis was conducted on 52 women with 89 pregnancies...
April 9, 2024: Lupus
#14
JOURNAL ARTICLE
Georgios Dragoutsos, Christina Tsiggalou, Efthymios Oikonomou, Anastasia Bothou, Grigorios Trypsiannis, Konstantinos Nikolettos, Christos Damaskos, Nikolaos Garmpis, Dimitrios Kyriakou, Theopi Nalbanti, Georgios Iatrakis, Nikolaos Nikolettos, Panagiotis Tsikouras
BACKGROUND: Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning of the immune system, which is to eliminate the 'foreign or/and dangerous' to mistakenly target the body's own tissues. OBJECTIVE: The aim of this research is to evaluate the most effective approach to managing autoimmune diseases within the framework of pregnancy. METHODS: The exact causes and etiologies of these diseases are multifactorial and mostly still unclear...
2024: Materia Socio-medica
#15
JOURNAL ARTICLE
Mika Hatano, Nobuyuki Yajima, Ryo Yanai, Sho Ishii, Yasushi Tsujimoto, Teruhisa Azuma, Tatsuya Atsumi, Yuko Kaneko, Hideto Kameda, Masataka Kuwana, Yoshiya Tanaka, Shiori Nakagawa, Ayako Nakajima, Yuri Hiramatsu, Daisuke Fujita, Takako Miyamae, Atsuko Murashima
OBJECTIVES: A quality indicator for the treatment of systemic lupus erythematosus during pregnancy and childbirth that is useful for sharing standard treatment policies has not yet been developed. This study aimed to develop a quality indicator for systemic lupus erythematosus associated with pregnancy and childbirth. METHODS: To identify candidate quality indicators, we conducted a systematic literature review on the development of quality indicators for systemic lupus erythematosus related to pregnancy and childbirth and on clinical practice guidelines...
April 8, 2024: Modern Rheumatology
#16
Reina Komatsu, Kazuya Mimura, Tatsuya Matsuyama, Yoko Kawanishi, Hitomi Nakamura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura
Severe cases of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome requiring plasma exchange or dialysis should be differentiated from other thrombotic microangiopathy (TMA) and treated appropriately. To evaluate the prevalence and clinical characteristics of such cases in Japan, a questionnaire-based survey was conducted among obstetricians who are members of the Perinatal Research Network Group in Japan. There were a total of 335 cases of HELLP syndrome over a 3-year period in the 48 facilities that responded to the survey...
April 8, 2024: Journal of Obstetrics and Gynaecology Research
#17
JOURNAL ARTICLE
Yeon Mi Hwang, Qi Wei, Samantha N Piekos, Bhargav Vemuri, Sevda Molani, Philip Mease, Leroy Hood, Jennifer Hadlock
BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are likely to complicate maternal health. However, literature on patients with IMIDs undergoing pregnancy is scarce and often overlooks the presence of comorbidities. We aimed to evaluate the impact of IMIDs on adverse pregnancy outcomes after assessing and addressing any discrepancies in the distribution of covariates associated with adverse pregnancy outcomes between patients with and without IMIDs. METHODS: We conducted a retrospective cohort study using data from an integrated U...
February 2024: EClinicalMedicine
#18
REVIEW
Katrien M J Devreese
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombotic manifestations and/or obstetric complications in patients with persistently positive antiphospholipid antibodies (aPL). aPL are a heterogeneous group of autoantibodies, but only lupus anticoagulant, anticardiolipin (aCL), and antibeta2-glycoprotein I antibodies (aβ2GPI) IgG or IgM are included as laboratory classification criteria. Seronegative APS patients are usually defined as patients with the clinical symptoms of APS but who test negative for aPL...
April 7, 2024: International Journal of Laboratory Hematology
#19
JOURNAL ARTICLE
Joanna Tingström, Elin Öst, Gunnar Bergman, Åsa Burström
OBJECTIVE: The aim of this study was to explore the parents' experiences of home monitoring of the fetal heart rhythm. Women with anti-SSA/Ro52 autoantibodies carry a 2%-3% risk of giving birth to a child with congenital heart block (CHB), following transplacental transfer and antibody-mediated inflammation in the fetal conduction system during 18th to 24th gestational week. Early detection and subsequent treatment have been reported to decrease morbidity and mortality. Therefore, home monitoring of the fetal heart rhythm by Doppler has been offered at our fetal cardiology center...
April 3, 2024: Lupus
#20
JOURNAL ARTICLE
Pia Elfving, Simo Kariniemi, Hannu Kautiainen, Vappu Rantalaiho, Lauri J Virta, Kari Puolakka, Merja K Laine
OBJECTIVES: The aim was to investigate, how pregnancies proceed in patients with systemic lupus erythematosus (SLE) compared to their individually matched population controls. MATERIAL AND METHODS: Adult incident SLE patients were identified from the register of new special reimbursement decisions for SLE drugs in 2000-2014. For each patient, 1-3 randomly selected controls from the Population Register Centre were matched. Data regarding pregnancies were obtained from the Finnish Medical Birth Register, Care Register and Register of Congenital Malformations until 2018...
April 2, 2024: Rheumatology International
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